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52410-74-9 | POLYETHYLENE GLYCOL 4000 DIMESYLATE
CAS No: 52410-74-9 Catalog No: AG00DIT1 MDL No:
Product Description
Catalog Number:
AG00DIT1
Chemical Name:
POLYETHYLENE GLYCOL 4000 DIMESYLATE
CAS Number:
52410-74-9
IUPAC Name:
2-methylsulfonyloxyethyl methanesulfonate
InChI:
InChI=1S/C4H10O6S2/c1-11(5,6)9-3-4-10-12(2,7)8/h3-4H2,1-2H3
InChI Key:
QSQFARNGNIZGAW-UHFFFAOYSA-N
UNII:
EW8V7BJ66Q
NSC Number:
17016
Properties
Complexity:
266
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
217.992g/mol
Formal Charge:
0
Heavy Atom Count:
12
Hydrogen Bond Acceptor Count:
6
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
218.238g/mol
Monoisotopic Mass:
217.992g/mol
Rotatable Bond Count:
5
Topological Polar Surface Area:
104A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-0.9
Literature
| Title | Journal |
|---|---|
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| The increased number of Leydig cells by di(2-ethylhexyl) phthalate comes from the differentiation of stem cells into Leydig cell lineage in the adult rat testis. | Toxicology 20130405 |
| Adverse effects of di-(2-ethylhexyl) phthalate on Leydig cell regeneration in the adult rat testis. | Toxicology letters 20121130 |
| The endocrine disruptors dibutyl phthalate (DBP) and diethylstilbestrol (DES) influence Leydig cell regeneration following ethane dimethane sulphonate treatment of adult male rats. | International journal of andrology 20120601 |
| Gene expression analysis of toxicological pathways in TM3 leydig cell lines treated with Ethane dimethanesulfonate. | Journal of biochemical and molecular toxicology 20120601 |
| Up-regulation of NDRG2 through nuclear factor-kappa B is required for Leydig cell apoptosis in both human and murine infertile testes. | Biochimica et biophysica acta 20120201 |
| Chromosome y regulates survival following murine coxsackievirus b3 infection. | G3 (Bethesda, Md.) 20120101 |
| Cyclic GMP signaling in rat urinary bladder, prostate, and epididymis: tissue-specific changes with aging and in response to Leydig cell depletion. | Reproduction (Cambridge, England) 20110801 |
| A predictive ligand-based Bayesian model for human drug-induced liver injury. | Drug metabolism and disposition: the biological fate of chemicals 20101201 |
| Ghrelin in female and male reproduction. | International journal of peptides 20100101 |
| Dynamics of INSL3 peptide expression in the rodent testis. | Biology of reproduction 20090901 |
| Genetic analysis and fine-mapping of a dwarfing with withered leaf-tip mutant in rice. | Journal of genetics and genomics = Yi chuan xue bao 20081201 |
| Expression of thyrotropin-releasing hormone receptors in rat testis and their role in isolated Leydig cells. | Cell and tissue research 20081101 |
| Leydig cell re-generation and expression of cell signaling molecules in the germ cell-free testis. | Reproduction (Cambridge, England) 20080601 |
| Differential expression and regulation of integral membrane protein 2b in rat male reproductive tissues. | Asian journal of andrology 20080501 |
| Epidermal growth factor mediates spermatogonial proliferation in newt testis. | Reproductive biology and endocrinology : RB&E 20080101 |
| INSLF3-LGR8 ligand-receptor system in testes of mature rats after exposure to ethane dimethanesulphonate (short communication). | Folia medica 20080101 |
| Essential roles of COUP-TFII in Leydig cell differentiation and male fertility. | PloS one 20080101 |
| c-erbAalpha and c-erbaAbeta in the Leydig cell repopulation by ethane-1,2-dimethanesulphonate model of mature rats. | Folia medica 20080101 |
| Studies on the expression of 80-kDa human sperm antigen in rat testis and epididymis. | The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20070701 |
| Protective effects of vitamin E on ethane dimethane sulfonate-induced testicular toxicity in rats. | Asian journal of andrology 20070101 |
| Postnatal expression and androgen regulation of HOXBES2 homeoprotein in rat epididymis. | Journal of andrology 20070101 |
| 11beta-hydroxysteroid dehydrogenase type 2 expression in the newly formed Leydig cells after ethane dimethanesulphonate treatment of adult rats. | Folia histochemica et cytobiologica 20070101 |
| Histological changes of the testis and epididymis in adult rats as a result of Leydig cell destruction after ethane dimethane sulfonate treatment: a morphometric study. | Asian journal of andrology 20060501 |
| Stage dependent and androgen inductive expression of orphan receptor TR4 in rat testis. | Biochemical and biophysical research communications 20060310 |
| Loss and recovery of androgen receptor protein expression in the adult rat testis following androgen withdrawal by ethane dimethanesulfonate. | Folia histochemica et cytobiologica 20060101 |
| Differential expression of members of the E2F family of transcription factors in rodent testes. | Reproductive biology and endocrinology : RB&E 20060101 |
| Hormonal regulation of Leydig cell proliferation and differentiation in rodent testis: a dynamic interplay between gonadotrophins and testicular factors. | Reproductive biomedicine online 20051001 |
| Androgen regulation of stage-dependent cyclin D2 expression in Sertoli cells suggests a role in modulating androgen action on spermatogenesis. | Biology of reproduction 20050501 |
| Regulatory cytokine expression and interstitial fluid formation in the normal and inflamed rat testis are under leydig cell control. | Journal of andrology 20050101 |
| Ghrelin inhibits the proliferative activity of immature Leydig cells in vivo and regulates stem cell factor messenger ribonucleic acid expression in rat testis. | Endocrinology 20041101 |
| Induction of male germ cell apoptosis by testosterone withdrawal after ethane dimethanesulfonate treatment in adult rats. | Endocrine regulations 20040901 |
| Testicular activity of Mos in the frog, Rana esculenta: a new role in spermatogonial proliferation. | Biology of reproduction 20040601 |
| DD-RT-PCR identifies 7-dehydrocholesterol reductase as a key marker of early Leydig cell steroidogenesis. | Molecular and cellular endocrinology 20040430 |
| Expression and regulation of lipocalin-type prostaglandin d synthase in rat testis and epididymis. | Biology of reproduction 20040401 |
| Specific dose-dependent effects of ethane 1,2-dimethanesulfonate in rat and mouse Leydig cells and non-steroidogenic cells on programmed cell death. | The Journal of endocrinology 20040401 |
| Müllerian-inhibiting substance inhibits rat Leydig cell regeneration after ethylene dimethanesulphonate ablation. | Biology of reproduction 20040301 |
| Evaluation of relative role of LH and FSH in restoration of spermatogenesis using ethanedimethylsulphonate-treated adult rats. | Reproductive biomedicine online 20040201 |
| Influence of cycloheximide on apoptosis in CHO cells, induced by ethane 1,2-dimethanesulphonate (EDS). | Roczniki Akademii Medycznej w Bialymstoku (1995) 20040101 |
| Gestational exposure to ethane dimethanesulfonate permanently alters reproductive competence in the CD-1 mouse. | Biology of reproduction 20030901 |
| Expression of fractalkine in the rat testis: molecular cloning of a novel alternative transcript of its gene that is differentially regulated by pro-inflammatory cytokines. | Molecular human reproduction 20030801 |
| Effects of gestational exposure to ethane dimethanesulfonate in CD-1 mice: microtia and preliminary hearing tests. | Birth defects research. Part B, Developmental and reproductive toxicology 20030801 |
| Endothelial cell proliferation in male reproductive organs of adult rat is high and regulated by testicular factors. | Biology of reproduction 20030401 |
| The role of the c-kit receptor in the regenerative differentiation of rat Leydig cells. | International journal of andrology 20030401 |
| Ethane 1,2-dimethane sulphonate is a useful tool for studying cell-to-cell interactions in the testis of the frog, Rana esculenta. | General and comparative endocrinology 20030301 |
| Effect of hormonal manipulation on mRNA expression of antioxidant enzymes in the rat testis. | The Journal of urology 20030201 |
| Evaluation of relative roles of LH and FSH in regulation of differentiation of Leydig cells using an ethane 1,2-dimethylsulfonate-treated adult rat model. | The Journal of endocrinology 20030101 |
| Effects of ethane dimethane sulfonate on the functional structure of the adult rat testis. | Archives of andrology 20030101 |
| Steroidogenic and structural differentiation of new Leydig cell population following exposure of adult rats to ethane dimethanesulphonate. | Folia biologica 20020101 |
| Degeneration and restoration of spermatogenesis in relation to the changes in Leydig cell population following ethane dimethanesulfonate treatment in adult rats. | Endocrine regulations 20011201 |
| Replacement of surgical castration by GnRH-inhibition or Leydig cell ablation in the male rat Hershberger antiandrogen assay. | Regulatory toxicology and pharmacology : RTP 20011001 |
| Expression of amphiphysin I in Sertoli cells and its implication in spermatogenesis. | Biochemical and biophysical research communications 20010928 |
| Expression of neurotrophin receptors in rat testis. Upregulation of TrkA mRNA with hCG treatment. | Molecular and cellular endocrinology 20010820 |
| Epididymal epithelial cell involution following a single intraperitoneal administration of ethane dimethanesulfonate in the goat (Capra hircus). | Toxicology and applied pharmacology 20010815 |
| Modulation of gene expression by androgen and oestrogens in the testis and prostate of the adult rat following androgen withdrawal. | Molecular and cellular endocrinology 20010610 |
| Opposite effects of dexamethasone and ACTH on the adrenal cortex response to ethane dimethanesulphonate (EDS). | Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20010401 |
| Differential expression and regulation of the retinoblastoma family of proteins during testicular development and spermatogenesis: roles in the control of germ cell proliferation, differentiation and apoptosis. | Oncogene 20010315 |
| Apoptosis related gene products in differentiated and tumorigenic rat Leydig cells and following regression induced by the cytotoxin ethane dimethanesulphonate. | International journal of andrology 20010201 |
| [Proliferation and differentiation of regenerating Leydig cells following ethylene dimethane sulfonate exposure in rats]. | Morfologiia (Saint Petersburg, Russia) 20010101 |
| Early testicular response to intraperitoneal administration of ethane dimethanesulphonate (EDS) in the goat (Capra hircus). | Journal of submicroscopic cytology and pathology 20010101 |
| Bcl-w forms complexes with Bax and Bak, and elevated ratios of Bax/Bcl-w and Bak/Bcl-w correspond to spermatogonial and spermatocyte apoptosis in the testis. | Molecular endocrinology (Baltimore, Md.) 20000501 |
| Assessment of the contribution of Leydig cells to the secretion of inhibin by the rat testis. | Molecular and cellular endocrinology 19891101 |
| The involvement of Leydig cells in the regulation of inhibin secretion by the testis. | Endocrinology 19890701 |
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