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522-66-7 | (8α,9R)-10,11-Dihydro-6'-methoxycinchonan-9-ol
CAS No: 522-66-7 Catalog No: AG0037RI MDL No:MFCD00151107
Product Description
Catalog Number:
AG0037RI
Chemical Name:
(8α,9R)-10,11-Dihydro-6'-methoxycinchonan-9-ol
CAS Number:
522-66-7
Molecular Formula:
C20H26N2O2
Molecular Weight:
326.4326
MDL Number:
MFCD00151107
IUPAC Name:
(R)-[(2S,4S,5R)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol
InChI:
InChI=1S/C20H26N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h4-6,8,11,13-14,19-20,23H,3,7,9-10,12H2,1-2H3/t13-,14-,19-,20+/m0/s1
InChI Key:
LJOQGZACKSYWCH-WZBLMQSHSA-N
SMILES:
CC[C@H]1CN2CC[C@H]1C[C@H]2[C@@H](c1ccnc2c1cc(OC)cc2)O
UNII:
31J3Q51T6L
Properties
Complexity:
432
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
4
Defined Bond Stereocenter Count:
0
Exact Mass:
326.199g/mol
Formal Charge:
0
Heavy Atom Count:
24
Hydrogen Bond Acceptor Count:
4
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
326.44g/mol
Monoisotopic Mass:
326.199g/mol
Rotatable Bond Count:
4
Topological Polar Surface Area:
45.6A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.1
Literature
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|---|---|
| Modified asymmetric Strecker reaction of aldehyde with secondary amine: a protocol for the synthesis of S-clopidogrel (an antiplatelet agent). | The Journal of organic chemistry 20120817 |
| [Malignant fascicular ventricular tachycardia degenerating into ventricular fibrillation in a patient with early repolarization syndrome]. | Annales de cardiologie et d'angeiologie 20120801 |
| Multifocal ectopic Purkinje-related premature contractions: a new SCN5A-related cardiac channelopathy. | Journal of the American College of Cardiology 20120710 |
| A novel hydroquinidine imprinted microsphere using a chirality-matching N-acryloyl-L-phenylalanine monomer for recognition of cinchona alkaloids. | Journal of chromatography. A 20120518 |
| Metabolism of 2-chloro-4-nitrophenol in a gram negative bacterium, Burkholderia sp. RKJ 800. | PloS one 20120101 |
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| Catalytic enantioselective protonation of enol trifluoroacetates by means of hydrogenocarbonates and cinchona alkaloids. | The Journal of organic chemistry 20110805 |
| Long-term follow-up of patients with short QT syndrome. | Journal of the American College of Cardiology 20110802 |
| The War against a Regional Disease in Japan A History of the Eradication of Schistosomiasis japonica. | Tropical medicine and health 20110301 |
| Inline pneumatically assisted atmospheric pressure matrix-assisted laser desorption/ionization ion trap mass spectrometry. | Journal of mass spectrometry : JMS 20100601 |
| Determination of nicardipine and amlodipine in human plasma using on-line solid-phase extraction with a monolithic weak cation-exchange column. | Talanta 20090115 |
| Characterization of phenoloxidase activity in Sydney rock oysters (Saccostrea glomerata). | Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20071201 |
| A clinical trial of topical bleaching treatment with nanoscale tretinoin particles and hydroquinone for hyperpigmented skin lesions. | Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 20070801 |
| Calculation of standard electrode potential of half reaction for benzoquinone and hydroquinone. | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20061001 |
| Monomorphic ventricular tachycardia due to Brugada syndrome successfully treated by hydroquinidine therapy in a 3-year-old child. | Journal of cardiovascular electrophysiology 20060101 |
| Hydroquinidine therapy in Brugada syndrome. | Journal of the American College of Cardiology 20040519 |
| Short QT syndrome: pharmacological treatment. | Journal of the American College of Cardiology 20040421 |
| [Adverse drug reactions in three older patients, even without changes in medication]. | Nederlands tijdschrift voor geneeskunde 20030329 |
| Proliferation and morphological transformation of RMK cells exposed to hydroquinine containing ionomers. | Biomedical sciences instrumentation 20020101 |
| Safety and effectiveness of oral quinidine in cardioversion of persistent atrial fibrillation. | Journal of cardiology 20011201 |
| Plasma concentrations of quinidine, its major metabolites, and dihydroquinidine in patients with torsades de pointes. | Clinical pharmacology and therapeutics 19880601 |
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