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51781-21-6 | 5-[3-(tert-butylamino)-1,1,2,3,3-pentadeuterio-2-hydroxypropoxy]-3,4-dihydro-1H-quinolin-2-one;hydrochloride
CAS No: 51781-21-6 Catalog No: AG00I993 MDL No:
Product Description
Catalog Number:
AG00I993
Chemical Name:
5-[3-(tert-butylamino)-1,1,2,3,3-pentadeuterio-2-hydroxypropoxy]-3,4-dihydro-1H-quinolin-2-one;hydrochloride
CAS Number:
51781-21-6
Molecular Formula:
C16H25ClN2O3
Molecular Weight:
328.8343
IUPAC Name:
5-[3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydro-1H-quinolin-2-one;hydrochloride
InChI:
InChI=1S/C16H24N2O3.ClH/c1-16(2,3)17-9-11(19)10-21-14-6-4-5-13-12(14)7-8-15(20)18-13;/h4-6,11,17,19H,7-10H2,1-3H3,(H,18,20);1H
InChI Key:
FYBXRCFPOTXTJF-UHFFFAOYSA-N
SMILES:
OC(COc1cccc2c1CCC(=O)N2)CNC(C)(C)C.Cl
EC Number:
257-415-7
Properties
Complexity:
354
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
328.155g/mol
Formal Charge:
0
Heavy Atom Count:
22
Hydrogen Bond Acceptor Count:
4
Hydrogen Bond Donor Count:
4
Isotope Atom Count:
0
Molecular Weight:
328.837g/mol
Monoisotopic Mass:
328.155g/mol
Rotatable Bond Count:
6
Topological Polar Surface Area:
70.6A^2
Undefined Atom Stereocenter Count:
1
Undefined Bond Stereocenter Count:
0
Literature
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|---|---|
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| Additive effect of dorzolamide or carteolol to latanoprost in primary open-angle glaucoma: a prospective randomized crossover trial. | Journal of glaucoma 20060801 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| Beta-blocker eye drops. | Nursing times 20060501 |
| [A case of severe glaucoma with pseudopemphigoid successfully treated by filtration surgery using amniotic membrane]. | Nippon Ganka Gakkai zasshi 20060401 |
| Environmentally responsive ophthalmic gel formulation of carteolol hydrochloride. | Drug delivery 20060101 |
| Comparison of the additive effects of nipradilol and carteolol to latanoprost in open-angle glaucoma. | Japanese journal of ophthalmology 20060101 |
| Comparison of carteolol plasmatic levels after repeated instillations of long-acting and regular formulations of carteolol 2% in glaucoma patients. | Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20051201 |
| In vitro evidence that carteolol is a nonconventional partial agonist of guinea pig cardiac beta1-adrenoceptors: a comparison with xamoterol. | The Journal of pharmacology and experimental therapeutics 20051201 |
| Carteolol hydrochloride protects human corneal epithelial cells from UVB-induced damage in vitro. | Cornea 20050301 |
| Ventricular tachycardia in a neonate with prenatally diagnosed cardiac tumors: a case with tuberous sclerosis. | Pediatric cardiology 20050101 |
| Beta 2-adrenoceptor-mediated intrinsic sympathomimetic activity of carteolol: an in vivo study. | Naunyn-Schmiedeberg's archives of pharmacology 20041101 |
| Effects of carteolol hydrochloride on the in vitro production of LPS-induced proinflammatory cytokines by murine macrophage. | Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20040601 |
| Characterization of intrinsic sympathomimetic activity of carteolol in rat cardiovascular preparations. | Journal of pharmacological sciences 20040501 |
| Latanoprost therapy in patients with glaucoma and ocular hypertension inadequately controlled with carteolol. | Japanese journal of ophthalmology 20040101 |
| [Neuroprotection and vasoprotection in glaucoma]. | Oftalmologia (Bucharest, Romania : 1990) 20040101 |
| Ocular factors relevant to anti-glaucomatous eyedrop-related keratoepitheliopathy. | Journal of glaucoma 20031201 |
| In vitro effects of preserved or preservative-free antiglaucoma medications on human complement system. | Current eye research 20031001 |
| A new method using pulmonary gas-exchange kinetics to evaluate efficacy of beta-blocking agents in patients with dilated cardiomyopathy. | Chest 20030901 |
| Cytoprotective effects of rebamipide and carteolol hydrochloride against ultraviolet B-induced corneal damage in mice. | Investigative ophthalmology & visual science 20030701 |
| Effects of commercial antiglaucoma drugs to glutamate-induced [Ca2+)]i increase in cultured neuroblastoma cells. | Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20030601 |
| [Efficacy and safety of long-acting carteolol 1% once daily. A double-masked, randomized study]. | Journal francais d'ophtalmologie 20030201 |
| Comparison of the intraocular pressure lowering effect of latanoprost and carteolol-pilocarpine combination in newly diagnosed glaucoma. | Japanese journal of ophthalmology 20030101 |
| Corneal neovascularization possibly associated with latanoprost therapy. | European journal of ophthalmology 20030101 |
| Pharmacokinetic and pharmacodynamic differences between ocular and nasal instillation of carteolol on intraocular pressure and heart rate in Japanese men with high CYP2D6 activity. | Journal of clinical pharmacology 20020901 |
| Ocular drug delivery using 20-kHz ultrasound. | Ultrasound in medicine & biology 20020601 |
| The beta-blocker carteolol inhibits contractions induced by KCl in pig ciliary arteries: an effect modulated by extracellular Ca++. | Klinische Monatsblatter fur Augenheilkunde 20020401 |
| Alginic acid effect on carteolol ocular pharmacokinetics in the pigmented rabbit. | Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20020201 |
| Topical beta blockers and atrioventricular block in the elderly. | Journal of postgraduate medicine 20020101 |
| Ocular and retrobulbar blood flow in ocular hypertensives treated with topical timolol, betaxolol and carteolol. | Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20011201 |
| Spontaneous hyphema secondary to iris vascular tufts. | Archives of ophthalmology (Chicago, Ill. : 1960) 20011101 |
| Heart function challenged with beta-receptor agonism or antagonism in a heart failure model. | Cardiovascular drugs and therapy 20011101 |
| Mitochondrial activity and glutathione injury in apoptosis induced by unpreserved and preserved beta-blockers on Chang conjunctival cells. | Investigative ophthalmology & visual science 20011001 |
| Color Doppler imaging of retrobulbar hemodynamics after topical carteolol in normal tension glaucoma. | Zhonghua yi xue za zhi = Chinese medical journal; Free China ed 20011001 |
| Short-term effect of beta-adrenoreceptor blocking agents on ocular blood flow. | Current eye research 20011001 |
| Ocular hypotensive efficacy and safety of once daily carteolol alginate. | The British journal of ophthalmology 20010801 |
| A 7 year prospective comparative study of three topical beta blockers in the management of primary open angle glaucoma. | The British journal of ophthalmology 20010801 |
| Allergic contact dermatitis due to the beta-blocker befunolol in eyedrops, with cross-sensitivity to carteolol. | Contact dermatitis 20010601 |
| Assessment of systemic adverse reactions induced by ophthalmic beta-adrenergic receptor antagonists. | Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20010601 |
| Functional properties of atypical beta-adrenoceptors on the guinea pig duodenum. | European journal of pharmacology 20010323 |
| The effects of beta-blockers on ocular blood flow in patients with primary open angle glaucoma: a color Doppler imaging study. | European journal of ophthalmology 20010101 |
| Color Doppler imaging study in patients with primary open-angle glaucoma treated with timolol 0.5% and carteolol 2%. | European journal of ophthalmology 20010101 |
| Cardiovascular considerations in using topical, oral, and intravenous drugs for the treatment of glaucoma and ocular hypertension: focus on beta-adrenergic blockade. | Heart disease (Hagerstown, Md.) 20010101 |
| Role of central nicotinic and beta-adrenergic receptors in the onset and further development of tail-tremor induced by repeated nicotine administration to rats. | Naunyn-Schmiedeberg's archives of pharmacology 19970501 |
| The attenuating effect of carteolol hydrochloride, a beta-adrenoceptor antagonist, on neuroleptic-induced catalepsy in rats. | Psychopharmacology 19970501 |
| Cardiovascular effects of topical carteolol hydrochloride and timolol maleate in patients with ocular hypertension and primary open-angle glaucoma. Night Study Group. | American journal of ophthalmology 19970401 |
| A comparison of the ocular hypotensive efficacy and systemic safety of 0.5% levobunolol and 2% carteolol. | Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 19940101 |
| Penbutolol and carteolol: two new beta-adrenergic blockers with partial agonism. | Journal of clinical pharmacology 19900501 |
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| Remission of mild to moderate hypertension after treatment with carteolol, a beta-adrenoceptor blocker with intrinsic sympathomimetic activity. | Archives of internal medicine 19880801 |
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