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51543-38-5 | [1,1'-Biphenyl]-4-acetic acid, 2-fluoro-a-methyl-, (±)-
CAS No: 51543-38-5 Catalog No: AG01FORW MDL No:
Product Description
Catalog Number:
AG01FORW
Chemical Name:
[1,1'-Biphenyl]-4-acetic acid, 2-fluoro-a-methyl-, (±)-
CAS Number:
51543-38-5
IUPAC Name:
2-(3-fluoro-4-phenylphenyl)propanoic acid
InChI:
InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)
InChI Key:
SYTBZMRGLBWNTM-UHFFFAOYSA-N
Properties
Complexity:
286
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
244.09g/mol
Formal Charge:
0
Heavy Atom Count:
18
Hydrogen Bond Acceptor Count:
3
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
244.265g/mol
Monoisotopic Mass:
244.09g/mol
Rotatable Bond Count:
3
Topological Polar Surface Area:
37.3A^2
Undefined Atom Stereocenter Count:
1
Undefined Bond Stereocenter Count:
0
XLogP3:
4.2
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| Tarenflurbil protection from cytotoxicity is associated with an upregulation of neurotrophins. | Journal of Alzheimer's disease : JAD 20081101 |
| The effects of etodolac, nimesulid and naproxen sodium on the frequency of sister chromatid exchange after enclused third molars surgery. | Yonsei medical journal 20081031 |
| Condensed bridgehead nitrogen heterocyclic system: synthesis and pharmacological activities of 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole derivatives of ibuprofen and biphenyl-4-yloxy acetic acid. | European journal of medicinal chemistry 20081001 |
| Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice. | Aging cell 20081001 |
| Safety and clinical responses in ankylosing spondylitis after three months of etanercept therapy. | Journal of Korean medical science 20081001 |
| Dihydrotanshinone, a lipophilic component of Salvia miltiorrhiza (danshen), relaxes rat coronary artery by inhibition of calcium channels. | Journal of ethnopharmacology 20080926 |
| Chiral ionic liquids for enantioseparation of pharmaceutical products by capillary electrophoresis. | Journal of chromatography. A 20080919 |
| Validation of a nonaqueous capillary electrophoretic method for the enantiomeric purity determination of R-flurbiprofen using a single-isomer amino cyclodextrin derivative. | Journal of chromatography. A 20080919 |
| Determining binding sites of drugs on human serum albumin using FIA-QCM. | Biosensors & bioelectronics 20080915 |
| Effect of some formulation parameters on flurbiprofen encapsulation and release rates of niosomes prepared from proniosomes. | International journal of pharmaceutics 20080901 |
| Improvement in bioavailability of transdermally applied flurbiprofen using tulsi (Ocimum sanctum) and turpentine oil. | Colloids and surfaces. B, Biointerfaces 20080901 |
| In vitro evaluation of proniosomes as a drug carrier for flurbiprofen. | AAPS PharmSciTech 20080901 |
| Improvement of dissolution property of poorly water-soluble drug by novel dry coating method using planetary ball mill. | Chemical & pharmaceutical bulletin 20080901 |
| Effect of pH and formulation variables on in vitro transcorneal permeability of flurbiprofen: a technical note. | AAPS PharmSciTech 20080901 |
| Determination of flurbiprofen enantiomers in plasma using a single-isomer amino cyclodextrin derivative in nonaqueous capillary electrophoresis. | Electrophoresis 20080901 |
| Alpha-methylprednisolone conjugated cyclodextrin polymer-based nanoparticles for rheumatoid arthritis therapy. | International journal of nanomedicine 20080901 |
| Ionic liquid-based dynamic liquid-phase microextraction: application to the determination of anti-inflammatory drugs in urine samples. | Journal of chromatography. A 20080815 |
| Present and prospective clinical therapeutic regimens for Alzheimer's disease. | Neuropsychiatric disease and treatment 20080801 |
| The effects of topical (gel) astemizole and terfenadine on wound healing. | Indian journal of pharmacology 20080801 |
| Substrate proton to heme distances in CYP2C9 allelic variants and alterations by the heterotropic activator, dapsone. | Archives of biochemistry and biophysics 20080715 |
| Characterization of the drug binding specificity of rat liver fatty acid binding protein. | Journal of medicinal chemistry 20080710 |
| Species differences in inhibition potential of nonsteroidal anti-inflammatory drugs against estradiol 3beta-glucuronidation between rats, dogs, and humans. | Journal of pharmaceutical sciences 20080701 |
| Method for comparing the structures of protein ligand-binding sites and application for predicting protein-drug interactions. | Proteins 20080701 |
| [Acute renal insufficiency after flurbiprofen treatment in a patient treated with angiotensin converting enzyme inhibitor]. | La Revue de medecine interne 20080701 |
| Differential genotype dependent inhibition of CYP2C9 in humans. | Drug metabolism and disposition: the biological fate of chemicals 20080701 |
| Addition of nitric oxide through nitric oxide-paracetamol enhances healing rat achilles tendon. | Clinical orthopaedics and related research 20080701 |
| Intravenous flurbiprofen axetil accelerates restoration of bowel function after colorectal surgery. | Canadian journal of anaesthesia = Journal canadien d'anesthesie 20080701 |
| Wet process-induced phase-transited drug delivery system: a means for achieving osmotic, controlled, and level A IVIVC for poorly water-soluble drug. | Drug development and industrial pharmacy 20080701 |
| Oral colon targeted delivery systems for treatment of inflammatory bowel diseases: synthesis, in vitro and in vivo assessment. | International journal of pharmaceutics 20080624 |
| Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). | Journal of medicinal chemistry 20080612 |
| Thermodynamic studies of Fenbufen, Diflunisal, and Flurbiprofen: sublimation, solution and solvation of biphenyl substituted drugs. | International journal of pharmaceutics 20080605 |
| Topical ocular delivery of NSAIDs. | The AAPS journal 20080601 |
| Efficacy and safety of tarenflurbil in mild to moderate Alzheimer's disease: a randomised phase II trial. | The Lancet. Neurology 20080601 |
| Tarenflurbil: a shot on goal. | The Lancet. Neurology 20080601 |
| Cloud point extraction-HPLC method for determination and pharmacokinetic study of flurbiprofen in rat plasma after oral and transdermal administration. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080601 |
| The therapeutic effects of Rho-ROCK inhibitors on CNS disorders. | Therapeutics and clinical risk management 20080601 |
| Topical ophthalmic NSAIDs: a discussion with focus on nepafenac ophthalmic suspension. | Clinical ophthalmology (Auckland, N.Z.) 20080601 |
| Rheological and functional characterization of new antiinflammatory delivery systems designed for buccal administration. | International journal of pharmaceutics 20080522 |
| Preparation and characterization of flurbiprofen-loaded poly(3-hydroxybutyrate-co-3-hydroxyvalerate) microspheres. | Journal of microencapsulation 20080501 |
| Optimizing delivery of flurbiprofen to the colon using a targeted prodrug approach. | The Journal of pharmacy and pharmacology 20080501 |
| Analysis of flurbiprofen, ketoprofen and etodolac enantiomers by pre-column derivatization RP-HPLC and application to drug-protein binding in human plasma. | Journal of pharmaceutical and biomedical analysis 20080414 |
| Impregnation of an intraocular lens for ophthalmic drug delivery. | Current drug delivery 20080401 |
| Osmotically regulated flow of flurbiprofen through in situ formed asymmetric membrane capsule. | Current drug delivery 20080401 |
| Investigation of nanostructured lipid carriers for transdermal delivery of flurbiprofen. | Drug development and industrial pharmacy 20080401 |
| [Application of flurbiprofen preemptive analgesia combined with intravenous propofol anesthesia in induced abortion]. | Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20080401 |
| Transient absorption spectroscopy for determining multiple site occupancy in drug-protein conjugates. A comparison between human and bovine serum albumins using flurbiprofen methyl ester as a probe. | The journal of physical chemistry. B 20080306 |
| Non-steroidal anti-inflammatory drugs have potent anti-fibrillogenic and fibril-destabilizing effects for alpha-synuclein fibrils in vitro. | Neuropharmacology 20080301 |
| Assessment of drug release from oil depot formulations using an in vitro model -- potential applicability in accelerated release testing. | Drug development and industrial pharmacy 20080301 |
| Development of enteric coated flurbiprofen tablets using Opadry/Acryl-Eze system--a technical note. | AAPS PharmSciTech 20080301 |
| Taking the next steps in the treatment of Alzheimer's disease: disease-modifying agents. | CNS spectrums 20080301 |
| Prediction of metabolism by cytochrome P450 2C9: alignment and docking studies of a validated database of substrates. | Journal of medicinal chemistry 20080227 |
| A comparison of the effectiveness of selected non-steroidal anti-inflammatory drugs and their derivatives against cancer cells in vitro. | Cancer chemotherapy and pharmacology 20080201 |
| Celecoxib inhibits proliferation of retinal pigment epithelial and choroid-retinal endothelial cells by a cyclooxygenase-2-independent mechanism. | The Journal of pharmacology and experimental therapeutics 20080201 |
| Modulatory effect of chiral nonsteroidal anti-inflammatory drugs on apoptosis of human neutrophils. | Chirality 20080201 |
| Synthesis and pharmacological evaluation of pyrazoline derivatives as new anti-inflammatory and analgesic agents. | Bioorganic & medicinal chemistry letters 20080201 |
| Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment. | European journal of clinical pharmacology 20080201 |
| Effects of selective and non-selective COX inhibitors on antigen-induced release of prostanoid mediators and bronchoconstriction in the isolated perfused and ventilated guinea pig lung. | Prostaglandins, leukotrienes, and essential fatty acids 20080201 |
| Comparison of lidocaine, metoclopramide, and flurbiprofen axetil for reducing pain on injection of propofol in Japanese adult surgical patients: a prospective, randomized, double-blind, parallel-group, placebo-controlled study. | Clinical therapeutics 20080201 |
| Celecoxib transiently inhibits cellular protein synthesis. | Biochemical pharmacology 20080115 |
| Mechanisms of the dilator action of cryptotanshinone on rat coronary artery. | European journal of pharmacology 20080114 |
| Prejunctional inhibitory effects of isoprostanes on dopaminergic neurotransmission in bovine retinae, in vitro. | Neurochemical research 20080101 |
| In vivo methods for the assessment of topical drug bioavailability. | Pharmaceutical research 20080101 |
| Flurbiprofen derivatives in Alzheimer's disease: synthesis, pharmacokinetic and biological assessment of lipoamino acid prodrugs. | Bioconjugate chemistry 20080101 |
| Dosage plan of a flurbiprofen injection product using inhibition of protein binding by lipid emulsion in rats. | The Journal of pharmacy and pharmacology 20080101 |
| [In-vitro evaluation of cinnarizine as a competing agent to beta-cyclodextrin inclusion complexes: effect of cinnarizine on the membrane permeation rate of progesterone from its beta-cyclodextrin inclusion complex]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20080101 |
| Cerebrospinal fluid matrix metalloproteinase-9 increases during treatment of recurrent malignant gliomas. | Cerebrospinal fluid research 20080101 |
| Formulation and evaluation of flurbiprofen microemulsion. | Current drug delivery 20080101 |
| Analgesic effect of percutaneously absorbed non-steroidal anti-inflammatory drugs: an experimental study in a rat acute inflammation model. | BMC musculoskeletal disorders 20080101 |
| Confirmatory identification of sixteen non-steroidal anti-inflammatory drug residues in raw milk by liquid chromatography coupled with ion trap mass spectrometry. | Rapid communications in mass spectrometry : RCM 20080101 |
| Transconjunctival orbital emphysema caused by compressed air injury: a case report. | Indian journal of ophthalmology 20080101 |
| Regulation of Glial Cell Functions by PPAR-gamma Natural and Synthetic Agonists. | PPAR research 20080101 |
| Straw blood cell count, growth, inhibition and comparison to apoptotic bodies. | BMC cell biology 20080101 |
| Molecular analysis of the effects of Piroxicam and Cisplatin on mesothelioma cells growth and viability. | Journal of translational medicine 20080101 |
| Interactions between APP secretases and inflammatory mediators. | Journal of neuroinflammation 20080101 |
| PPAR-gamma: Therapeutic Potential for Multiple Sclerosis. | PPAR research 20080101 |
| PPARs in Alzheimer's Disease. | PPAR research 20080101 |
| Mitochondrial Ca2+ overload underlies Abeta oligomers neurotoxicity providing an unexpected mechanism of neuroprotection by NSAIDs. | PloS one 20080101 |
| Efficacy of intraoperative vancomycin in irrigating solutions on aqueous contamination during phacoemulsification. | Indian journal of ophthalmology 20080101 |
| Acquired Brown's syndrome associated with preseptal cellulitis. | Strabismus 20080101 |
| Quantification of gamma-secretase modulation differentiates inhibitor compound selectivity between two substrates Notch and amyloid precursor protein. | Molecular brain 20080101 |
| Nitric oxide and cardiovascular effects: new insights in the role of nitric oxide for the management of osteoarthritis. | Arthritis research & therapy 20080101 |
| Role of nitric oxide in the gastrointestinal tract. | Arthritis research & therapy 20080101 |
| Inflammaging as a prodrome to Alzheimer's disease. | Journal of neuroinflammation 20080101 |
| Cyclooxygenase inhibitors: a novel direction for Alzheimer's management. | Pharmacological reports : PR 20080101 |
| A role for non-antimicrobial actions of tetracyclines in combating oxidative stress in periodontal and metabolic diseases: a literature review. | The open dentistry journal 20080101 |
| Surgical results of triamcinolone assisted pars plana vitrectomy combined with phacoemulsification in diabetic patients. | The open ophthalmology journal 20080101 |
| Transcorneal permeation in a corneal device of non-steroidal anti-inflammatory drugs in drug delivery systems. | The open medicinal chemistry journal 20080101 |
| A Study on Improvement of Solubility of Rofecoxib and its effect on Permeation of Drug from Topical Formulations. | Indian journal of pharmaceutical sciences 20080101 |
| Diclofenac patches for postoperative shoulder pain. | International journal of shoulder surgery 20080101 |
| In situ formed phase transited drug delivery system of ketoprofen for achieving osmotic, controlled and level a in vitro in vivo correlation. | Indian journal of pharmaceutical sciences 20080101 |
| Pharmacological nature of nicotine-induced contraction in the rat basilar artery: involvement of arachidonic acid metabolites. | European journal of pharmacology 20071222 |
| Involvement of organic anion transport system in transdermal absorption of flurbiprofen. | Journal of controlled release : official journal of the Controlled Release Society 20071204 |
| 1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretase modulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicity. | The Journal of pharmacology and experimental therapeutics 20071201 |
| The p38 MAPK pathway mediates aryl propionic acid induced messenger rna stability of p75 NTR in prostate cancer cells. | Cancer research 20071201 |
| Preoperative flurbiprofen for pain prevention after tonsillectomy in adults. | Journal of clinical anesthesia 20071201 |
| Anti-inflammatory and immune therapy for Alzheimer's disease: current status and future directions. | Current neuropharmacology 20071201 |
| Analgesic and anti-inflammatory effectiveness of nepafenac 0.1% for cataract surgery. | Clinical ophthalmology (Auckland, N.Z.) 20071201 |
| The thermodynamic dissociation constants of four non-steroidal anti-inflammatory drugs by the least-squares nonlinear regression of multiwavelength spectrophotometric pH-titration data. | Journal of pharmaceutical and biomedical analysis 20071130 |
| Flurbiprofen, a cyclooxygenase inhibitor, reduces the brain arachidonic acid signal in response to the cholinergic muscarinic agonist, arecoline, in awake rats. | Neurochemical research 20071101 |
| New form discovery for the analgesics flurbiprofen and sulindac facilitated by polymer-induced heteronucleation. | Journal of pharmaceutical sciences 20071101 |
| The UDP-glucuronosyltransferase 2B7 isozyme is responsible for gemfibrozil glucuronidation in the human liver. | Drug metabolism and disposition: the biological fate of chemicals 20071101 |
| [Management of antiplatelet therapy: a case report]. | Annales de cardiologie et d'angeiologie 20071101 |
| Analysis of skin disposition of flurbiprofen after topical application using dual agar gel discs-inserted rats. | Biological & pharmaceutical bulletin 20071101 |
| Relative non-steroidal anti-inflammatory drug (NSAID) antiproliferative activity is mediated through p21-induced G1 arrest and E2F inhibition. | Molecular carcinogenesis 20071001 |
| Beta-amyloid(1-42) induces a reduction in the parallel fiber responses of Purkinje cells: possible involvement of pro-inflammatory processes. | Experimental gerontology 20071001 |
| A validated method for the analysis of diltiazem in raw materials and pharmaceutical formulations by rp-HPLC. | Pakistan journal of pharmaceutical sciences 20071001 |
| Imaging the Abeta-related neurotoxicity of Alzheimer disease. | Archives of neurology 20071001 |
| [Effect of postoperative analgesia with flurbiprofen axetil and sufentanyl on metabolism of surgical patients with intestinal carcinoma]. | Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20071001 |
| Osmotic delivery of flurbiprofen through controlled porosity asymmetric membrane capsule. | Drug development and industrial pharmacy 20071001 |
| [Is withdrawal of antiplatelet therapy necessary prior to skin cancer surgery?]. | Annales de dermatologie et de venereologie 20071001 |
| GCF MMP-8 levels in smokers and non-smokers with chronic periodontitis following scaling and root planing accompanied by systemic use of flurbiprofen. | Journal of periodontology 20071001 |
| Progress update: Pharmacological treatment of Alzheimer's disease. | Neuropsychiatric disease and treatment 20071001 |
| The amyloid beta ion channel hypothesis of Alzheimer's disease. | Neuropsychiatric disease and treatment 20071001 |
| Topical antiinflammatory activity of an innovative aqueous formulation of actichelated propolis vs two commercial propolis formulations. | Phytotherapy research : PTR 20070901 |
| Preparation and evaluation of biodegradable flubiprofen gelatin micro-spheres for intra-articular administration. | Journal of microencapsulation 20070901 |
| Mechanisms of the vasorelaxant effect of 1-hydroxy-2, 3, 5-trimethoxy-xanthone, isolated from a Tibetan herb, Halenia elliptica, on rat coronary artery. | Life sciences 20070901 |
| Asymmetric membrane capsule for osmotic delivery of flurbiprofen. | Acta pharmaceutica (Zagreb, Croatia) 20070901 |
| Effective virtual screening protocol for CYP2C9 ligands using a screening site constructed from flurbiprofen and S-warfarin pockets. | Journal of computer-aided molecular design 20070901 |
| Pathogenesis of Alzheimer's disease. | Clinical interventions in aging 20070901 |
| Carboxylesterase in the liver and small intestine of experimental animals and human. | Life sciences 20070823 |
| Excited-state interactions in flurbiprofen-tryptophan dyads. | The journal of physical chemistry. B 20070809 |
| Multidrug resistance protein 1 (MRP1) in rabbit conjunctival epithelial cells: its effect on drug efflux and its regulation by adenoviral infection. | Pharmaceutical research 20070801 |
| An Aging Interventions Testing Program: study design and interim report. | Aging cell 20070801 |
| Flurbiprofen in the symptomatic management of rheumatoid arthritis: a valuable alternative. | International journal of clinical practice 20070801 |
| Cross-reaction allergic pancreatitis with ketoprofen and flurbiprofen. | Pancreas 20070801 |
| One-step preparation of drug-containing microparticles to enhance the dissolution and absorption of poorly water-soluble drugs using a 4-fluid nozzle spray drier. | Journal of controlled release : official journal of the Controlled Release Society 20070731 |
| Predominant contribution of UDP-glucuronosyltransferase 2B7 in the glucuronidation of racemic flurbiprofen in the human liver. | Drug metabolism and disposition: the biological fate of chemicals 20070701 |
| CYP2C9 protein interactions with cytochrome b(5): effects on the coupling of catalysis. | Drug metabolism and disposition: the biological fate of chemicals 20070701 |
| Binary polymeric blends to microencapsulate nitroflurbiprofen: physicochemical and in silico studies. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20070701 |
| In vitro interaction studies of diltiazem with NSAID's using UV spectrophotometry and RP-HPLC techniques. | Pakistan journal of pharmaceutical sciences 20070701 |
| Simultaneous analysis of cytochrome P450 probes-dextromethorphan, flurbiprofen and midazolam and their major metabolites by HPLC-mass-spectrometry/fluorescence after single-step extraction from plasma. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070615 |
| Electrokinetic migration of acidic drugs across a supported liquid membrane. | Journal of chromatography. A 20070608 |
| Nanoparticles in modern medicine: state of the art and future challenges. | International journal of nanomedicine 20070601 |
| Mucoadhesive bilayered tablets for buccal sustained release of flurbiprofen. | AAPS PharmSciTech 20070601 |
| R-stereopreference analysis of lipase Novozym 435 in kinetic resolution of flurbiprofen. | Chirality 20070505 |
| Identification of flurbiprofen and its photoproducts in methanol by gas chromatography-mass spectrometry. | Biomedical chromatography : BMC 20070501 |
| Differential regulation of BACE1 promoter activity by nuclear factor-kappaB in neurons and glia upon exposure to beta-amyloid peptides. | Journal of neuroscience research 20070501 |
| Traditional nonsteroidal anti-inflammatory drugs and postmenopausal hormone therapy: a drug-drug interaction? | PLoS medicine 20070501 |
| Structural and functional basis of cyclooxygenase inhibition. | Journal of medicinal chemistry 20070405 |
| Evaluation of flurbiprofen urinary ratios as in vivo indices for CYP2C9 activity. | British journal of clinical pharmacology 20070401 |
| In vitro and in vivo profiling of CHF5022 and CHF5074 Two beta-amyloid1-42 lowering agents. | Pharmacological research 20070401 |
| The aryl propionic acid R-flurbiprofen selectively induces p75NTR-dependent decreased survival of prostate tumor cells. | Cancer research 20070401 |
| Design and optimization of NSAID loaded nanoparticles. | Pakistan journal of pharmaceutical sciences 20070401 |
| Calcium-activated endoplasmic reticulum stress as a major component of tumor cell death induced by 2,5-dimethyl-celecoxib, a non-coxib analogue of celecoxib. | Molecular cancer therapeutics 20070401 |
| [A novel class of anti-inflammatory and analgesic drugs--NO-donating NSAIDs]. | Yao xue xue bao = Acta pharmaceutica Sinica 20070401 |
| Pharmacological characterization of receptor types mediating the dilator action of anandamide on blood vessels of the rat knee joint. | Life sciences 20070327 |
| Use of simple docking methods to screen a virtual library for heteroactivators of cytochrome P450 2C9. | Journal of medicinal chemistry 20070322 |
| Preadministration of flurbiprofen suppresses prostaglandin production and postoperative pain in orthopedic patients undergoing tourniquet inflation. | Journal of clinical anesthesia 20070301 |
| Ternary complexes of flurbiprofen with HP-beta-CD and ethanolamines characterization and transdermal delivery. | Drug development and industrial pharmacy 20070301 |
| [Very late intrastent thrombosis--at 27 months!]. | Archives des maladies du coeur et des vaisseaux 20070301 |
| Amyloid-beta vaccination, but not nitro-nonsteroidal anti-inflammatory drug treatment, increases vascular amyloid and microhemorrhage while both reduce parenchymal amyloid. | Neuroscience 20070209 |
| Factors affecting the formation of eutectic solid dispersions and their dissolution behavior. | Journal of pharmaceutical sciences 20070201 |
| Non-carboxylic analogues of arylpropionic acids: synthesis, anti-inflammatory activity and ulcerogenic potential. | European journal of medicinal chemistry 20070201 |
| Nitroflurbiprofen, a nitric oxide-releasing cyclooxygenase inhibitor, improves cirrhotic portal hypertension in rats. | Gastroenterology 20070201 |
| Drug evaluation: (R)-flurbiprofen--an enantiomer of flurbiprofen for the treatment of Alzheimer's disease. | IDrugs : the investigational drugs journal 20070201 |
| Flurbiprofen: new indication. Lozenges: NSAIDs are not to be taken like sweets! | Prescrire international 20070201 |
| Gingival crevicular fluid prostaglandin E(2) and thiobarbituric acid reactive substance levels in smokers and non-smokers with chronic periodontitis following phase I periodontal therapy and adjunctive use of flurbiprofen. | Journal of periodontology 20070101 |
| Unilateral conjunctival chemosis as a unique symptom of nonsteroidal anti-inflammatory drug intolerance. | Journal of investigational allergology & clinical immunology 20070101 |
| Electrospray ionization/atmospheric pressure photoionization multimode source for low-flow liquid chromatography/mass spectrometric analysis. | Rapid communications in mass spectrometry : RCM 20070101 |
| Design and synthesis of some new thiazolo [3,2-b]-1,2,4-triazole-5(6H)-ones substituted with flurbiprofen as anti-inflammatory and analgesic agents. | Arzneimittel-Forschung 20070101 |
| Inflammation and breast cancer. Cyclooxygenase/prostaglandin signaling and breast cancer. | Breast cancer research : BCR 20070101 |
| Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice. | BMC neuroscience 20070101 |
| Emulsion of flurbiprofen axetil reduces propofol injection pain due to a decrease in free propofol concentration. | Journal of anesthesia 20070101 |
| Exploring effects of different nonsteroidal antiinflammatory drugs on lipid peroxidation. Part II. 4-HNE profile. | Acta poloniae pharmaceutica 20070101 |
| Modulation of hypericin photodynamic therapy by pretreatment with 12 various inhibitors of arachidonic acid metabolism in colon adenocarcinoma HT-29 cells. | Photochemistry and photobiology 20070101 |
| Functional evolution of the vitamin D and pregnane X receptors. | BMC evolutionary biology 20070101 |
| Molecular cloning and functional expression of esf gene encoding enantioselective lipase from Serratia marcescens ES-2 for kinetic resolution of optically active (S)-flurbiprofen. | Journal of microbiology and biotechnology 20070101 |
| Bortezomib in combination with celecoxib in patients with advanced solid tumors: a phase I trial. | BMC cancer 20070101 |
| Safety, tolerability, pharmacokinetics, and Abeta levels after short-term administration of R-flurbiprofen in healthy elderly individuals. | Alzheimer disease and associated disorders 20070101 |
| A tale of switched functions: from cyclooxygenase inhibition to M-channel modulation in new diphenylamine derivatives. | PloS one 20070101 |
| Assay principle for modulators of protein-protein interactions and its application to non-ATP-competitive ligands targeting protein kinase A. | Analytical chemistry 20061215 |
| CYP2C9 inhibition: impact of probe selection and pharmacogenetics on in vitro inhibition profiles. | Drug metabolism and disposition: the biological fate of chemicals 20061201 |
| Gene expression profiling in R-flurbiprofen-treated prostate cancer: R-Flurbiprofen regulates prostate stem cell antigen through activation of AKT kinase. | Biochemical pharmacology 20061115 |
| Flurbiprofen loaded biodegradable nanoparticles for ophtalmic administration. | Journal of pharmaceutical sciences 20061101 |
| Flurbiprofen and its nitric oxide-releasing derivative protect against septic shock in rats. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20061101 |
| Synthesis and pharmacological evaluation of some dual-acting amino-alcohol ester derivatives of flurbiprofen and 2-[1,1'-biphenyl-4-yl]acetic acid: a potential approach to reduce local gastrointestinal toxicity. | Chemistry & biodiversity 20061101 |
| Substrate specificity of carboxylesterase isozymes and their contribution to hydrolase activity in human liver and small intestine. | Drug metabolism and disposition: the biological fate of chemicals 20061001 |
| [Clinical observation of propofol combined with flurbiprofen axetil for induced abortion anesthesia]. | Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20061001 |
| Phacoemulsification and acryl foldable intraocular lens implantation in dogs: 32 cases. | Journal of veterinary science 20060901 |
| Use of triplet excited States for the study of drug binding to human and bovine serum albumins. | ChemMedChem 20060901 |
| Molecular properties of flurbiprofen and its solid dispersions with Eudragit RL100 studied by high- and low-resolution solid-state nuclear magnetic resonance. | Pharmaceutical research 20060901 |
| Validation of incorporating flurbiprofen into the Pittsburgh cocktail. | Clinical pharmacology and therapeutics 20060901 |
| Osmotic flow through asymmetric membrane: a means for controlled delivery of drugs with varying solubility. | AAPS PharmSciTech 20060901 |
| Prophylaxis of migraine. | Neuropsychiatric disease and treatment 20060901 |
| Design and evaluation of colon specific drug delivery system containing flurbiprofen microsponges. | International journal of pharmaceutics 20060802 |
| Vancomycin as chiral selector for enantioselective separation of selected profen nonsteroidal anti-inflammatory drugs in capillary liquid chromatography. | Chirality 20060801 |
| Antioxidant activity and inhibition of human neutrophil oxidative burst mediated by arylpropionic acid non-steroidal anti-inflammatory drugs. | Biological & pharmaceutical bulletin 20060801 |
| Influence of age on flurbiprofen axetil requirements for preventing pain on injection of propofol in Japanese adult surgical patients: a prospective, randomized, double-blind, vehicle-controlled, parallel-group, dose-ranging study. | Clinical therapeutics 20060801 |
| Prevention of corneal neovascularization: evaluation of various commercially available compounds in an experimental rat model. | Cornea 20060801 |
| Study on the mechanism of photosensitive dermatitis caused by ketoprofen in the guinea pig. | Archives of toxicology 20060701 |
| Prostaglandin E2 and BDNF levels in rat hippocampus are negatively correlated with status epilepticus severity: no impact on survival of seizure-generated neurons. | Neurobiology of disease 20060701 |
| Pharmacokinetic parameters of (R)-(-) and (S)-(+)-flurbiprofen in dairy bovines. | Veterinary research communications 20060701 |
| Chamazulene carboxylic acid and matricin: a natural profen and its natural prodrug, identified through similarity to synthetic drug substances. | Journal of natural products 20060701 |
| In vitro interactions of captopril with NSAID's. | Pakistan journal of pharmaceutical sciences 20060701 |
| Factors involved in upregulation of inducible nitric oxide synthase in rat small intestine following administration of nonsteroidal anti-inflammatory drugs. | Digestive diseases and sciences 20060701 |
| Determination of ibuprofen and flurbiprofen in pharmaceuticals by capillary zone electrophoresis. | Journal of pharmaceutical and biomedical analysis 20060616 |
| Anti-inflammatory agents in the management of alimentary mucositis. | Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20060601 |
| In vivo and in vitro evaluation of essential oils from Ligusticum chuanxiong Hort on the transdermal delivery of flurbiprofen in rabbits. | Biological & pharmaceutical bulletin 20060601 |
| The effect of combinations of flurbiprofen, low molecular weight heparin, and doxycycline on the inhibition of corneal neovascularization. | Cornea 20060601 |
| In vitro metabolism of (nitrooxy)butyl ester nitric oxide-releasing compounds: comparison with glyceryl trinitrate. | The Journal of pharmacology and experimental therapeutics 20060501 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| Brain uptake of nonsteroidal anti-inflammatory drugs: ibuprofen, flurbiprofen, and indomethacin. | Pharmaceutical research 20060501 |
| Improving the diagnosis and treatment of Alzheimer's disease. | Medicine and health, Rhode Island 20060501 |
| The geminal dimethyl analogue of Flurbiprofen as a novel Abeta42 inhibitor and potential Alzheimer's disease modifying agent. | Bioorganic & medicinal chemistry letters 20060415 |
| Mechanisms of the vasorelaxant effect of Danshen (Salvia miltiorrhiza) in rat knee joints. | Journal of ethnopharmacology 20060406 |
| Dynamic regulation of microglial functions by the non-steroidal anti-inflammatory drug NCX 2216: implications for chronic treatments of neurodegenerative diseases. | Neurobiology of disease 20060401 |
| Proton sensitivity Ca2+ permeability and molecular basis of acid-sensing ion channels expressed in glabrous and hairy skin afferents. | Journal of neurophysiology 20060401 |
| Nitric oxide-releasing flurbiprofen reduces formation of proinflammatory hydrogen sulfide in lipopolysaccharide-treated rat. | British journal of pharmacology 20060401 |
| Effect of cyclooxygenase inhibitors on the micturition reflex in rats: correlation with inhibition of cyclooxygenase isozymes. | BJU international 20060401 |
| Controlled porosity osmotic pump for the delivery of flurbiprofen. | Current drug delivery 20060401 |
| An epidural initial dose is unnecessary in combined spinal epidural anesthesia for Caesarean section. | Journal of Nippon Medical School = Nippon Ika Daigaku zasshi 20060401 |
| Comparison of the percutaneous absorption of hydrophilic and lipophilic compounds in shed snake skin and human skin. | Die Pharmazie 20060401 |
| [On the new guidelines for inhibitors of hemostasis and regional neuraxial anesthesia]. | Revista espanola de anestesiologia y reanimacion 20060301 |
| Characterization of the transdermal transport of flurbiprofen and indomethacin. | Journal of controlled release : official journal of the Controlled Release Society 20060221 |
| Ginkgo biloba does not alter clearance of flurbiprofen, a cytochrome P450-2C9 substrate. | Journal of clinical pharmacology 20060201 |
| Dual effect of flurbiprofen on cell proliferation and agonist-induced Ca(2+) movement in human osteosarcoma cells. | Basic & clinical pharmacology & toxicology 20060201 |
| Arachidonic acid activates phosphatidylinositol 3-kinase signaling and induces gene expression in prostate cancer. | Cancer research 20060201 |
| Drug nanoparticle formation from drug/HPMC/SDS ternary ground mixtures. | Die Pharmazie 20060201 |
| Preparation of submicron unilamellar liposomes by freeze-drying double emulsions. | Biochimica et biophysica acta 20060201 |
| Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: in vitro and clinical studies. | Clinical pharmacology and therapeutics 20060101 |
| Preparation and characterization of poly(D,L-lactic-co-glycolic Acid) microspheres containing flurbiprofen sodium. | Drug delivery 20060101 |
| Preoperative administration of intravenous flurbiprofen axetil reduces postoperative pain for spinal fusion surgery. | Journal of anesthesia 20060101 |
| Downregulation of survivin expression and concomitant induction of apoptosis by celecoxib and its non-cyclooxygenase-2-inhibitory analog, dimethyl-celecoxib (DMC), in tumor cells in vitro and in vivo. | Molecular cancer 20060101 |
| Dyspnea assessment and adverse events during sputum induction in COPD. | BMC pulmonary medicine 20060101 |
| Pathological and physiological functions of presenilins. | Molecular neurodegeneration 20060101 |
| Mitochondrial oxidative damage in aging and Alzheimer's disease: implications for mitochondrially targeted antioxidant therapeutics. | Journal of biomedicine & biotechnology 20060101 |
| Determination of fourteen non-steroidal anti-inflammatory drugs in animal serum and plasma by liquid chromatography/mass spectrometry. | Rapid communications in mass spectrometry : RCM 20060101 |
| Atypical cytochrome p450 kinetics: implications for drug discovery. | Drugs in R&D 20060101 |
| The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer's disease. | Journal of neuroinflammation 20060101 |
| Multi-residue determination of non-steroidal anti-inflammatory drug residues in animal serum and plasma by HPLC and photo-diode array detection. | Journal of chromatographic science 20060101 |
| Exploring effects of different nonsteroidal antiinflammatory drugs on malondialdehyde profile. | Acta poloniae pharmaceutica 20060101 |
| Non-steroidal anti-inflammatory drugs have anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro. | Neuropharmacology 20051201 |
| Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease. | PLoS medicine 20051201 |
| Anterior scleritis, scleral thinning, and intraocular pressure measurement. | Ocular immunology and inflammation 20051201 |
| 'In vitro' differences among (R) and (S) enantiomers of profens in their activities related to articular pathophysiology. | Inflammation 20051201 |
| Transmural gradient of leukocyte-endothelial interaction in the rat gastrointestinal tract. | American journal of physiology. Gastrointestinal and liver physiology 20051101 |
| Impact of CYP2C9 genotype on pharmacokinetics: are all cyclooxygenase inhibitors the same? | Drug metabolism and disposition: the biological fate of chemicals 20051101 |
| The unexpected side effects of new nonsteroidal anti-inflammatory drugs. | Expert opinion on emerging drugs 20051101 |
| Preparation of two-drug composite microparticles to improve the dissolution of insoluble drug in water for use with a 4-fluid nozzle spray drier. | Journal of controlled release : official journal of the Controlled Release Society 20051020 |
| Novel therapeutic opportunities for Alzheimer's disease: focus on nonsteroidal anti-inflammatory drugs. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20051001 |
| Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion. | Journal of medicinal chemistry 20050908 |
| Arachidonic acid, an omega-6 fatty acid, induces cytoplasmic phospholipase A2 in prostate carcinoma cells. | Carcinogenesis 20050901 |
| CYP2C9 genotype-dependent effects on in vitro drug-drug interactions: switching of benzbromarone effect from inhibition to activation in the CYP2C9.3 variant. | Molecular pharmacology 20050901 |
| Mechanisms of the dilator action of Danshen (Salvia miltiorrhiza) on rat isolated femoral artery. | Journal of cardiovascular pharmacology 20050901 |
| Poly(amidoamine) (PAMAM) dendritic nanostructures for controlled site-specific delivery of acidic anti-inflammatory active ingredient. | AAPS PharmSciTech 20050901 |
| Effects of non-ionic surfactants on isotachophoretic separations of 2-arylpropionic acids. | Journal of chromatography. A 20050819 |
| Experimental optimization of enzymic kinetic resolution of racemic flurbiprofen. | Biotechnology and applied biochemistry 20050801 |
| Targeting the beta-catenin/APC pathway: a novel mechanism to explain the cyclooxygenase-2-independent anticarcinogenic effects of celecoxib in human colon carcinoma cells. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050801 |
| Flurbiprofen and HCT1026 protect mice against acute pancreatitis-associated lung injury. | Shock (Augusta, Ga.) 20050801 |
| Effect of pore size of FSM-16 on the entrapment of flurbiprofen in mesoporous structures. | Chemical & pharmaceutical bulletin 20050801 |
| Involvement of endothelial cyclo-oxygenase metabolites in noradrenaline-induced contraction of rat coronary artery. | Clinical and experimental pharmacology & physiology 20050801 |
| Development of fast-dissolving tablets of flurbiprofen-cyclodextrin complexes. | Drug development and industrial pharmacy 20050801 |
| Triplet excited States as chiral reporters for the binding of drugs to transport proteins. | Journal of the American Chemical Society 20050727 |
| Encapsulation efficiency of water-soluble and insoluble drugs in liposomes prepared by the microencapsulation vesicle method. | International journal of pharmaceutics 20050714 |
| Glucuronidation of nonsteroidal anti-inflammatory drugs: identifying the enzymes responsible in human liver microsomes. | Drug metabolism and disposition: the biological fate of chemicals 20050701 |
| Incidence of mucocutaneous reactions in children treated with niflumic acid, other nonsteroidal antiinflammatory drugs, or nonopioid analgesics. | Pediatrics 20050701 |
| Evaluation of a local anaesthesia regimen using a subphrenic catheter after gynaecological laparoscopy. | European journal of anaesthesiology 20050601 |
| Reversal of elution order for profen acid enantiomers in packed-column SFC on Chiralpak AD. | Chirality 20050515 |
| Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk). | Journal of medicinal chemistry 20050505 |
| Flurbiprofen axetil preceded by venous occlusion in the prevention of pain on propofol injection in the hand: a prospective, randomized, double-blind, vehicle-controlled, dose-finding study in Japanese adult surgical patients. | Clinical therapeutics 20050501 |
| Dissolution, solubility, XRD, and DSC studies on flurbiprofen-nicotinamide solid dispersions. | Drug development and industrial pharmacy 20050501 |
| Development and validation of HPLC method for determination of indomethacin and its two degradation products in topical gel. | Journal of pharmaceutical and biomedical analysis 20050429 |
| Determination of stability constant values of flurbiprofen-cyclodextrin complexes using different techniques. | Journal of pharmaceutical and biomedical analysis 20050429 |
| Predicting human serum albumin affinity of interleukin-8 (CXCL8) inhibitors by 3D-QSPR approach. | Journal of medicinal chemistry 20050407 |
| A combined first principles computational and solid-state NMR study of a molecular crystal: flurbiprofen. | Physical chemistry chemical physics : PCCP 20050407 |
| UDP-glucuronosyltransferases and clinical drug-drug interactions. | Pharmacology & therapeutics 20050401 |
| Transgenic AD model mice, effects of potential anti-AD treatments on inflammation and pathology. | Brain research. Brain research reviews 20050401 |
| Activity of flurbiprofen and chemically related anti-inflammatory drugs in models of Alzheimer's disease. | Brain research. Brain research reviews 20050401 |
| Preparation and in vitro characterization of a semi-solid dispersion of flurbiprofen with Gelucire 44/14 and Labrasol. | Die Pharmazie 20050401 |
| Induction of apoptosis by R-flurbiprofen in human colon carcinoma cells: involvement of p53. | Biochemical pharmacology 20050301 |
| Cytochrome P-450 activity is differentially altered in severely injured patients. | Critical care medicine 20050301 |
| Synthesis of some new 2-(2-fluoro-4-biphenylyl)propionic acid derivatives as potential anti-inflammatory agents. | Die Pharmazie 20050301 |
| Pain control during fixed orthodontic appliance therapy. | The Angle orthodontist 20050301 |
| Ocular pharmacology of bicyclic hexahydroaporphines. | Methods and findings in experimental and clinical pharmacology 20050301 |
| Perioperative sonoclot analysis in patients given flurbiprofen. | European journal of anaesthesiology 20050301 |
| Molecule of the month. MPC-7869 (Flurizan). | Drug news & perspectives 20050301 |
| The addition of epidural morphine to ropivacaine improves epidural analgesia after lower abdominal surgery. | Canadian journal of anaesthesia = Journal canadien d'anesthesie 20050201 |
| Nuclear receptor peroxisome proliferator-activated receptor-gamma is activated in rat microglial cells by the anti-inflammatory drug HCT1026, a derivative of flurbiprofen. | Journal of neurochemistry 20050201 |
| The effect of systemic administration of ibuprofen in the experimental gingivitis model. | Journal of clinical periodontology 20050201 |
| Separation strategy for acidic chiral pharmaceuticals with capillary electrochromatography on polysaccharide stationary phases. | Electrophoresis 20050201 |
| Pharmacokinetics and synovial fluid concentrations of flurbiprofen enantiomers in horses: chiral inversion. | Journal of veterinary pharmacology and therapeutics 20050201 |
| NSAIDs increase GM-CSF release by human synoviocytes: comparison with nitric oxide-donating derivatives. | European journal of pharmacology 20050131 |
| Effect of combined use of nonionic surfactant on formation of oil-in-water microemulsions. | International journal of pharmaceutics 20050106 |
| Lack of specific amyloid-beta(1-42) suppression by nonsteroidal anti-inflammatory drugs in young, plaque-free Tg2576 mice and in guinea pig neuronal cultures. | The Journal of pharmacology and experimental therapeutics 20050101 |
| Clinical effects of flurbiprofen tooth patch on radiation-induced oral mucositis. A pilot study. | Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20050101 |
| Changes in mechanical, chemical, and thermal sensitivity of the cornea after topical application of nonsteroidal anti-inflammatory drugs. | Investigative ophthalmology & visual science 20050101 |
| Dual effect of isoprostanes on the release of [3H]D-aspartate from isolated bovine retinae: role of arachidonic acid metabolites. | Neurochemical research 20050101 |
| Effect of nonsteroidal anti-inflammatory drugs with varying extent of COX-2-COX-1 selectivity on urinary sodium and potassium excretion in the rat. | Canadian journal of physiology and pharmacology 20050101 |
| Study of the percutaneous penetration of flurbiprofen by cutaneous and subcutaneous microdialysis after iontophoretic delivery in rat. | Journal of pharmaceutical sciences 20050101 |
| Differential modulation of microglia superoxide anion and thromboxane B2 generation by the marine manzamines. | BMC pharmacology 20050101 |
| Formulation studies and in vivo evaluation of a flurbiprofen-hydroxypropyl beta-cyclodextrin system. | Pharmaceutical development and technology 20050101 |
| Sample pretreatment and determination of non steroidal anti-inflammatory drugs (NSAIDs) in pharmaceutical formulations and biological samples (blood, plasma, erythrocytes) by HPLC-UV-MS and micro-HPLC. | Current medicinal chemistry 20050101 |
| [Results of an open prospective controlled randomized comparative trial of flurbiprofen and paracetamol efficacy and tolerance in patients with throat pain]. | Terapevticheskii arkhiv 20050101 |
| The effects of non-steroidal anti-inflammatory drugs (selective and non-selective) on the treatment of periodontal diseases. | Current pharmaceutical design 20050101 |
| Pain management after lumbar spinal fusion surgery using continuous subcutaneous infusion of buprenorphine. | Journal of anesthesia 20050101 |
| Solid lipid nanoparticles bearing flurbiprofen for transdermal delivery. | Drug delivery 20050101 |
| Transdermal delivery of flurbiprofen: permeation enhancement, design, pharmacokinetic, and pharmacodynamic studies in albino rats. | Pharmaceutical development and technology 20050101 |
| Treatment of pseudophakic cystoid macular oedema. | Collegium antropologicum 20050101 |
| How to decrease pain at rapid injection of propofol: effectiveness of flurbiprofen. | Journal of anesthesia 20050101 |
| Effects of co-administered dexamethasone and diclofenac potassium on pain, swelling and trismus following third molar surgery. | Head & face medicine 20050101 |
| Long-term use of non-steroidal anti-inflammatory drugs and the risk of myocardial infarction in the general population. | BMC medicine 20050101 |
| Adjuvant arthritis-induced changes on ampicillin binding in serum and tissues under the influence of non-steroidal anti-inflammatory drugs in rats. | European journal of drug metabolism and pharmacokinetics 20050101 |
| Analgesic effect of sustained-release flurbiprofen administered at the site of tissue injury in the oral surgery model. | Journal of clinical pharmacology 20041201 |
| Pretreatment with flurbiprofen axetil and venous occlusion to reduce pain during injection of propofol. | Canadian journal of anaesthesia = Journal canadien d'anesthesie 20041201 |
| Enantioseparation of flurbiprofen and ketoprofen in patches and in urine excretions by achiral gas chromatography. | Archives of pharmacal research 20041201 |
| The cyclooxygenase inhibitor flurbiprofen reduces radiation-induced angiogenic growth factor secretion of squamous cell carcinoma cell lines. | Annals of the New York Academy of Sciences 20041201 |
| Excised porcine skin experimental systems to validate quantitative microdialysis methods for determination of drugs in skin after topical application. | Journal of controlled release : official journal of the Controlled Release Society 20041124 |
| A cyclooxygenase metabolite of anandamide causes inhibition of interleukin-2 secretion in murine splenocytes. | The Journal of pharmacology and experimental therapeutics 20041101 |
| Calculation of cyclodextrin binding affinities: energy, entropy, and implications for drug design. | Biophysical journal 20041101 |
| Evaluation of the bioavailability of flurbiprofen and its beta-cyclodextrin inclusion complex in four different doses upon oral administration to rats. | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20041101 |
| Non-steroidal anti-inflammatory drugs (NSAIDs) in Alzheimer's disease: old and new mechanisms of action. | Journal of neurochemistry 20041101 |
| The potential role of non-steroidal anti-inflammatory drugs in treating Alzheimer's disease. | Expert opinion on investigational drugs 20041101 |
| Docking studies on NSAID/COX-2 isozyme complexes using contact statistics analysis. | Journal of computer-aided molecular design 20041101 |
| Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism. | The Journal of biological chemistry 20041015 |
| The effects and metabolic fate of nitroflurbiprofen in healthy volunteers. | Clinical pharmacology and therapeutics 20041001 |
| Interactions between aspirin and COX-2 inhibitors or NSAIDs in a rat thrombosis model. | Fundamental & clinical pharmacology 20041001 |
| A simplified analytical method for a phenotyping cocktail of major CYP450 biotransformation routes. | Journal of pharmaceutical and biomedical analysis 20040903 |
| Cationic vesicles as chiral selector for enantioseparations of nonsteroidal antiinflammatory drugs by micellar electrokinetic chromatography. | Journal of chromatography. A 20040903 |
| The flurbiprofen derivatives HCT1026 and HCT1027 inhibit bone resorption by a mechanism independent of COX inhibition and nitric oxide production. | Bone 20040901 |
| Effect of camellia oil on the permeation of flurbiprofen and diclofenac sodium through rat and pig skin. | Biological & pharmaceutical bulletin 20040901 |
| The structure of human cytochrome P450 2C9 complexed with flurbiprofen at 2.0-A resolution. | The Journal of biological chemistry 20040820 |
| Risk of breast cancer among users of aspirin and other anti-inflammatory drugs. | British journal of cancer 20040802 |
| Gastrointestinally distributed UDP-glucuronosyltransferase 1A10, which metabolizes estrogens and nonsteroidal anti-inflammatory drugs, depends upon phosphorylation. | The Journal of biological chemistry 20040702 |
| Bioinversion of R-flurbiprofen to S-flurbiprofen at various dose levels in rat, mouse, and monkey. | Chirality 20040701 |
| S- but not R-enantiomers of flurbiprofen and ibuprofen reduce human microglial and THP-1 cell neurotoxicity. | Journal of neuroimmunology 20040701 |
| Characterisation of the rapid release of activin A following acute lipopolysaccharide challenge in the ewe. | The Journal of endocrinology 20040701 |
| NO-donating nonsteroidal antiinflammatory drugs (NSAIDs) inhibit colon cancer cell growth more potently than traditional NSAIDs: a general pharmacological property? | Biochemical pharmacology 20040615 |
| Effector-mediated alteration of substrate orientation in cytochrome P450 2C9. | Biochemistry 20040608 |
| Cyclooxygenase involvement in thromboxane-dependent contraction in rat mesenteric resistance arteries. | Hypertension (Dallas, Tex. : 1979) 20040601 |
| Replication of the Weber effect using postmarketing adverse event reports voluntarily submitted to the United States Food and Drug Administration. | Pharmacotherapy 20040601 |
| Influence of preparation methodology on solid-state properties of an acidic drug-cyclodextrin system. | The Journal of pharmacy and pharmacology 20040601 |
| HPLC microdetermination of flurbiprofen enantiomers in plasma with a glycopeptide-type chiral stationary phase column. | Biomedical chromatography : BMC 20040601 |
| A rabbit ear flap perfusion experiment to evaluate the percutaneous absorption of drugs. | International journal of pharmaceutics 20040519 |
| Fatty acids in Botryococcus braunii accelerate topical delivery of flurbiprofen into and across skin. | International journal of pharmaceutics 20040519 |
| Differential activation of CYP2C9 variants by dapsone. | Biochemical pharmacology 20040515 |
| Responsiveness of C-fiber nociceptors to punctate force-controlled stimuli in isolated rat skin: lack of modulation by inflammatory mediators and flurbiprofen. | Neuroscience letters 20040506 |
| Enantioseparation of hydrochloride salts using carbon dioxide-based mobile phases with on-line polarimetric detection. | Chirality 20040505 |
| Gastric tolerability and prolonged prostaglandin inhibition in the brain with a nitric oxide-releasing flurbiprofen derivative, NCX-2216 [3-[4-(2-fluoro-alpha-methyl-[1,1'-biphenyl]-4-acetyloxy)-3-methoxyphenyl]-2-propenoic acid 4-nitrooxy butyl ester]. | The Journal of pharmacology and experimental therapeutics 20040501 |
| Renal expression of COX-2, ANG II, and AT1 receptor in remnant kidney: strong renoprotection by therapy with losartan and a nonsteroidal anti-inflammatory. | American journal of physiology. Renal physiology 20040501 |
| A nitric oxide releasing derivative of flurbiprofen inhibits experimental autoimmune encephalomyelitis. | Journal of neuroimmunology 20040501 |
| Nitroflurbiprofen (NicOx). | Current opinion in investigational drugs (London, England : 2000) 20040501 |
| Arachidonic acid metabolites and peroxide-induced inhibition of [3H]D-aspartate release from bovine isolated retinae. | Current eye research 20040501 |
| Resolution of indobufen enantiomers by capillary zone electrophoresis. Pharmacokinetic studies of human serum. | Journal of chromatography. A 20040402 |
| Differential roles of Arg97, Asp293, and Arg108 in enzyme stability and substrate specificity of CYP2C9. | Molecular pharmacology 20040401 |
| Nonsteroidal anti-inflammatory drug-induced liver injury: a case-control study in primary care. | Fundamental & clinical pharmacology 20040401 |
| The influence on human osteoblasts in vitro of non-steroidal anti-inflammatory drugs which act on different cyclooxygenase enzymes. | The Journal of bone and joint surgery. British volume 20040401 |
| Thermodynamics of solutions III: comparison of the solvation of (+)-naproxen with other NSAIDs. | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20040301 |
| Acid-sensing ion channels (ASICs): new targets for the analgesic effects of non-steroid anti-inflammatory drugs (NSAIDs). | Current drug targets. Inflammation and allergy 20040301 |
| Subantimicrobial dose doxycycline efficacy as a matrix metalloproteinase inhibitor in chronic periodontitis patients is enhanced when combined with a non-steroidal anti-inflammatory drug. | Journal of periodontology 20040301 |
| Solvation and hydration characteristics of ibuprofen and acetylsalicylic acid. | AAPS pharmSci 20040301 |
| Manipulation of kinetic profiles in 2-aryl propionic acid cyclooxygenase inhibitors. | Bioorganic & medicinal chemistry letters 20040209 |
| Placing bets. National Institute on Aging committee chooses three compounds for definitive longevity testing. | Science of aging knowledge environment : SAGE KE 20040204 |
| Granulocyte colony-stimulating factor (filgrastim) treatment primes for increased ex vivo inducible prostanoid release. | The Journal of pharmacology and experimental therapeutics 20040201 |
| Modeling of adhesion in tablet compression. II. Compaction studies using a compaction simulator and an instrumented tablet press. | Journal of pharmaceutical sciences 20040201 |
| In vitro release and stereoselective disposition of flurbiprofen loaded to poly(D,L-lactide- co-glycolide) nanoparticles in rats. | Chirality 20040201 |
| Intravenous administration of flurbiprofen does not affect cerebral blood flow velocity and cerebral oxygenation under isoflurane and propofol anesthesia. | Anesthesia and analgesia 20040201 |
| Microglial activation facilitates Abeta plaque removal following intracranial anti-Abeta antibody administration. | Neurobiology of disease 20040201 |
| Investigation of the release test method for the topical application of pharmaceutical preparations: release test of cataplasm including nonsteroidal anti-inflammatory drugs using artificial sweat. | Chemical & pharmaceutical bulletin 20040201 |
| Optimization of sample stacking for the simultaneous determination of nonsteroidal anti-inflammatory drugs with a wall-coated histidine capillary column. | Electrophoresis 20040201 |
| Possible involvement of the endocannabinoid system in the actions of three clinically used drugs. | Trends in pharmacological sciences 20040201 |
| Effect of nitric oxide releasing paracetamol and flurbiprofen on cytokine production in human blood. | European journal of pharmacology 20040112 |
| The 2.0 A resolution crystal structure of prostaglandin H2 synthase-1: structural insights into an unusual peroxidase. | Journal of molecular biology 20040109 |
| Endotoxin inhibits the surge secretion of gonadotropin-releasing hormone via a prostaglandin-independent pathway. | Endocrinology 20040101 |
| Modulation of beta-amyloid metabolism by non-steroidal anti-inflammatory drugs in neuronal cell cultures. | Journal of neurochemistry 20040101 |
| Arthritis medication studied for Alzheimer's disease prevention. | Mayo Clinic women's healthsource 20040101 |
| [Safety of a novel preparation -- strepfen -- for symptomatic treatment of pain in the throat]. | Vestnik otorinolaringologii 20040101 |
| Monolateral coxitis as a unique osteoarticular manifestation of Parvovirus B19 infection. | Clinical and experimental rheumatology 20040101 |
| In vitro proliferation of fibrosarcoma cells depends on intact functions of lipoxygenases and cytochrome P-450-monooxygenase. | Cancer investigation 20040101 |
| Lipid nano/submicron emulsions as vehicles for topical flurbiprofen delivery. | Drug delivery 20040101 |
| Cullen frontal sinus valved glaucoma shunt: preliminary findings in dogs with primary glaucoma. | Veterinary ophthalmology 20040101 |
| Topical NSAIDs for chronic musculoskeletal pain: systematic review and meta-analysis. | BMC musculoskeletal disorders 20040101 |
| Comparison between flurbiprofen and its nitric oxide-releasing derivatives HCT-1026 and NCX-2216 on Abeta(1-42)-induced brain inflammation and neuronal damage in the rat. | International journal of immunopathology and pharmacology 20040101 |
| Characterisation of the lowest singlet and triplet excited states of S-flurbiprofen. | Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20040101 |
| [Results of an open prospective controlled randomized comparative trial of efficacy and tolerance of sublingual tablets flurbiprofen (strepfen) and paracetamol in patients with throat pain in acute infectious-inflammatory diseases of the upper respiratory tracts]. | Vestnik otorinolaringologii 20040101 |
| Reduction of Propofol-Induced Pain through Pretreatment with Lidocaine and/or Flurbiprofen. | Clinical drug investigation 20040101 |
| Thermodynamics of solutions IV: Solvation of ketoprofen in comparison with other NSAIDs. | Journal of pharmaceutical sciences 20031201 |
| Different in vitro activity of flurbiprofen and its enantiomers on human articular cartilage. | Farmaco (Societa chimica italiana : 1989) 20031201 |
| Effects of anti-inflammatory drugs on convulsant activity of quinolones: a comparative study of drug interaction between quinolones and anti-inflammatory drugs. | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20031201 |
| Prednisolone and flurbiprofen drops to maintain mydriasis during phacoemulsification cataract surgery. | Journal of cataract and refractive surgery 20031201 |
| Noradrenaline-induced contraction mediated by endothelial COX-1 metabolites in the rat coronary artery. | Journal of cardiovascular pharmacology 20031201 |
| Inflammatory mediators do not stimulate CGRP release if prostaglandin synthesis is blocked by S(+)-flurbiprofen in isolated rat skin. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20031201 |
| An in vitro study of corpus cavernosum and aorta from mice lacking the inducible nitric oxide synthase gene. | Nitric oxide : biology and chemistry 20031201 |
| Contact dermatitis from peppermint and menthol in a local action transcutaneous patch. | Contact dermatitis 20031201 |
| Preparation and characterization of flurbiprofen beads by melt solidification technique. | AAPS PharmSciTech 20031201 |
| [Prescription of NSAIDs in patients treatment with platelet inhibitors or anticoagulants]. | Presse medicale (Paris, France : 1983) 20031122 |
| [Comparison of analgesic effects of intravenous flurbprofen and suppository indomethacin after laparoscopic cholecystectomy]. | Masui. The Japanese journal of anesthesiology 20031101 |
| P2Y2 receptor-stimulated release of prostaglandin E2 by rat inner medullary collecting duct preparations. | American journal of physiology. Renal physiology 20031001 |
| Inhibition of the rat hepatic microsomal flurbiprofen acyl glucuronidation by bile acids. | Journal of pharmaceutical sciences 20031001 |
| The comparison of efficacies of topical corticosteroids and nonsteroidal anti-inflammatory drops on dry eye patients: a clinical and immunocytochemical study. | American journal of ophthalmology 20031001 |
| 4'-hydroxylation of flurbiprofen by rat liver microsomes in fasting and feeding conditions. | Biological & pharmaceutical bulletin 20031001 |
| Evaluation of the contribution of cyclooxygenase 1 and cyclooxygenase 2 to the production of PGE2 and PGF2 alpha in epithelial cells from bovine endometrium. | Reproduction (Cambridge, England) 20031001 |
| Disposition of flurbiprofen in man: influence of stereochemistry and age. | Xenobiotica; the fate of foreign compounds in biological systems 20031001 |
| Stereospecific high-performance liquid chromatographic analysis of flurbiprofen: application to pharmacokinetic studies. | Journal of pharmaceutical and biomedical analysis 20030915 |
| Capillary electrophoresis with laser induced-fluorescence detection of profens derivatized with the water-soluble fluorogenic reagent 4-N-(4-N'-aminoethyl)piperazino-7-nitro-2,1,3-benzoxadiazole. | Journal of chromatography. A 20030905 |
| Characterisation of somatostatin actions on knee joint blood vessels of the rat. | European journal of pharmacology 20030808 |
| NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo. | The Journal of clinical investigation 20030801 |
| Unoprostone isopropyl ester darkens iris color in pigmented rabbits with sympathetic denervation. | Journal of glaucoma 20030801 |
| Simultaneous chiral discrimination of multiple profens by cyclodextrin-modified capillary electrophoresis in normal and reversed polarity modes. | Electrophoresis 20030801 |
| Thermodynamics of solutions. II. Flurbiprofen and diflunisal as models for studying solvation of drug substances. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20030801 |
| Inhibitors of cyclooxygenase-2, but not cyclooxygenase-1 provide structural and functional protection against quinolinic acid-induced neurodegeneration. | The Journal of pharmacology and experimental therapeutics 20030701 |
| Activation of c-Jun-N-terminal-kinase is crucial for the induction of a cell cycle arrest in human colon carcinoma cells caused by flurbiprofen enantiomers. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030701 |
| The influence of brain inflammation upon neuronal adenosine A2B receptors. | Journal of neurochemistry 20030701 |
| Thin layer chromatographic resolution of some 2-arylpropionic acid enantiomers using L-(-)-serine, L-(-)-threonine and a mixture of L-(-)-serine and L-(-)-threonine-impregnated silica gel as stationary phases. | Biomedical chromatography : BMC 20030701 |
| S+ -flurbiprofen but not 5-HT1 agonists suppress basal and stimulated CGRP and PGE2 release from isolated rat dura mater. | Pain 20030601 |
| Determination of the eicosanoid response to inflammatory stimuli in whole blood and its pharmacological modulation ex vivo. | Journal of immunological methods 20030601 |
| Addition of nitric oxide via nitroflurbiprofen enhances the material properties of early healing of young rat Achilles tendons. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20030601 |
| Dextrans--potential polymeric drug carriers for flurbiprofen. | Die Pharmazie 20030601 |
| Stereoselective pharmacokinetics of flurbiprofen and formation of covalent adducts with plasma protein in adjuvant-induced arthritic rats. | Chirality 20030515 |
| Solubilization of flurbiprofen in pH-surfactant solutions. | Journal of pharmaceutical sciences 20030501 |
| Non-steroidal anti-inflammatory drugs inhibit nitric oxide-induced apoptosis and dedifferentiation of articular chondrocytes independent of cyclooxygenase activity. | The Journal of biological chemistry 20030425 |
| In vitro and in vivo evaluations of the efficacy and safety of skin permeation enhancers using flurbiprofen as a model drug. | International journal of pharmaceutics 20030414 |
| Modeling of adhesion in tablet compression--I. Atomic force microscopy and molecular simulation. | Journal of pharmaceutical sciences 20030401 |
| Differences in flurbiprofen pharmacokinetics between CYP2C9*1/*1, *1/*2, and *1/*3 genotypes. | European journal of clinical pharmacology 20030401 |
| Inhibition of nuclear factor-kappaB by a nitro-derivative of flurbiprofen: a possible mechanism for antiinflammatory and antiproliferative effect. | Antioxidants & redox signaling 20030401 |
| Mechanisms of vasorelaxation to testosterone in the rat aorta. | European journal of pharmacology 20030328 |
| Paracetamol effectively reduces prostaglandin E2 synthesis in brain macrophages by inhibiting enzymatic activity of cyclooxygenase but not phospholipase and prostaglandin E synthase. | Journal of neuroscience research 20030315 |
| Anandamide metabolism by fatty acid amide hydrolase in intact C6 glioma cells. Increased sensitivity to inhibition by ibuprofen and flurbiprofen upon reduction of extra- but not intracellular pH. | Naunyn-Schmiedeberg's archives of pharmacology 20030301 |
| Flurbiprofen inhibits capsaicin induced calcitonin gene related peptide release from rat spinal cord via an endocannabinoid dependent mechanism. | Neuroscience letters 20030227 |
| [Diclofenac sodium or pred forte in the topical treatment of the fribrinous membrane after intraocular lens implantation in rabbits]. | Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University 20030227 |
| Activation of cytochrome P450 2C9-mediated metabolism: mechanistic evidence in support of kinetic observations. | Archives of biochemistry and biophysics 20030201 |
| Intrathecally applied flurbiprofen produces an endocannabinoid-dependent antinociception in the rat formalin test. | The European journal of neuroscience 20030201 |
| Acidic nonsteroidal anti-inflammatory drugs inhibit rat brain fatty acid amide hydrolase in a pH-dependent manner. | Journal of enzyme inhibition and medicinal chemistry 20030201 |
| Effect of enhancers and retarders on percutaneous absorption of flurbiprofen from hydrogels. | International journal of pharmaceutics 20030116 |
| Cyclooxygenase-2 expression by nonsteroidal anti-inflammatory drugs in human airway smooth muscle cells: role of peroxisome proliferator-activated receptors. | Journal of immunology (Baltimore, Md. : 1950) 20030115 |
| Effect of dextran as a run buffer additive in drug-protein binding studies using capillary electrophoresis frontal analysis. | Analytical chemistry 20030115 |
| Calcium-dependent synergistic interaction of platelet activating factor and epinephrine in human platelet aggregation. | Acta pharmacologica Sinica 20030101 |
| Tolbutamide, flurbiprofen, and losartan as probes of CYP2C9 activity in humans. | Journal of clinical pharmacology 20030101 |
| Enhancement of selectivity and resolution in the enantioseparation of uncharged compounds using mixtures of oppositely charged cyclodextrins in capillary electrophoresis. | Electrophoresis 20030101 |
| Topical nonsteroidal anti-inflammatory therapy in ophthalmology. | Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 20030101 |
| Formulation study and anti-inflammatory efficacy of topical semi-solids containing a nitro ester of flurbiprofen. | Skin pharmacology and applied skin physiology 20030101 |
| The stereospecificity of flobufen metabolism in isolated guinea pig hepatocytes. | BMC pharmacology 20030101 |
| Tranexamic acid: a review of its use in the management of menorrhagia. | Drugs 20030101 |
| Flurbiprofen, a unique non-steroidal anti-inflammatory drug with antimicrobial activity against Trichophyton, Microsporum and Epidermophyton species. | Letters in applied microbiology 20030101 |
| Modifications of clonidine binding to rabbit liver protein under the influence of non-steroid-anti-inflammatory drugs in vitro. | European journal of drug metabolism and pharmacokinetics 20030101 |
| Effects of non-steroidal anti-inflammatory drugs on cancer sites other than the colon and rectum: a meta-analysis. | BMC cancer 20030101 |
| Regulation of intraluteal production of prostaglandins. | Reproductive biology and endocrinology : RB&E 20030101 |
| Capillary electrochromatographic separation of non-steroidal anti-inflammatory drugs with a histidine bonded phase. | Journal of chromatography. A 20021227 |
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| Kinetics of allopregnanolone formation catalyzed by human 3 alpha-hydroxysteroid dehydrogenase type III (AKR1C2). | Biochemistry 20021112 |
| NO-flurbiprofen maintains duodenal blood flow, enhances mucus secretion contributing to lower mucosal injury. | American journal of physiology. Gastrointestinal and liver physiology 20021101 |
| Activation of CYP2C9-mediated metabolism by a series of dapsone analogs: kinetics and structural requirements. | Drug metabolism and disposition: the biological fate of chemicals 20021101 |
| Centrally administered galanin-like peptide modifies food intake in the rat: a comparison with galanin. | Journal of neuroendocrinology 20021101 |
| Selective inhibition of Abeta42 production by NSAID R-enantiomers. | Journal of neurochemistry 20021101 |
| Drug therapy of urinary urge incontinence: a systematic review. | Obstetrics and gynecology 20021101 |
| A nitric oxide-donating flurbiprofen derivative reduces neuroinflammation without interacting with galantamine in the rat. | European journal of pharmacology 20021025 |
| Efficient synthesis of alpha-aryl esters by room-temperature palladium-catalyzed coupling of aryl halides with ester enolates. | Journal of the American Chemical Society 20021023 |
| Structure-function relationship and role of tumor necrosis factor-alpha-converting enzyme in the down-regulation of L-selectin by non-steroidal anti-inflammatory drugs. | The Journal of biological chemistry 20021011 |
| Thermodynamic study of the enantiomeric resolution of flurbiprofen by HPLC using Chiralpak AD-RH column. | Die Pharmazie 20021001 |
| Biochemical stabilization enhances red blood cell recovery and stability following cryopreservation. | Cryobiology 20021001 |
| Rapid and simple quantitative assay method for diastereomeric flurbiprofen glucuronides in the incubation mixture. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020825 |
| Metabolic profile of NO-flurbiprofen (HCT1026) in rat brain and plasma: a LC-MS study. | Life sciences 20020816 |
| Flurbiprofen-loaded acrylate polymer nanosuspensions for ophthalmic application. | Biomaterials 20020801 |
| Prostaglandin synthesis inhibitor affects humoral conditions and oxygen metabolism during normothermic cardiopulmonary bypass. | Artificial organs 20020801 |
| Dissection of metabolic, vascular, and nerve conduction interrelationships in experimental diabetic neuropathy by cyclooxygenase inhibition and acetyl-L-carnitine administration. | Diabetes 20020801 |
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| In vitro release studies of flurbiprofen from different topical formulations. | Drug development and industrial pharmacy 20020801 |
| The cannabinoids R(-)-7-hydroxy-delta-6-tetra-hydrocannabinol-dimethylheptyl (HU-210), 2-O-arachidonoylglycerylether (HU-310) and arachidonyl-2-chloroethylamide (ACEA) increase isoflurane provoked sleep duration by activation of cannabinoids 1 (CB1)-receptors in mice. | Neuroscience letters 20020705 |
| Characterization of the bone-resorptive effect of interleukin-11 in cultured mouse calvarial bones. | Bone 20020701 |
| Flurbiprofen does not change the bispectral index and 95% spectral edge frequency during total intravenous anaesthesia with propofol and fentanyl. | European journal of anaesthesiology 20020701 |
| Prevention by parenteral aspirin of indomethacin-induced gastric lesions in rats: mediation by salicylic acid. | Digestive diseases and sciences 20020701 |
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| Catalytic properties of rice alpha-oxygenase. A comparison with mammalian prostaglandin H synthases. | The Journal of biological chemistry 20020621 |
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| Preparation of solid dispersions of nonsteroidal anti-inflammatory drugs with acrylic polymers and studies on mechanisms of drug-polymer interactions. | AAPS PharmSciTech 20020601 |
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| Identification of drug-binding sites on human serum albumin using affinity capillary electrophoresis and chemically modified proteins as buffer additives. | Electrophoresis 20020301 |
| Multidose flurbiprofen 8.75 mg lozenges in the treatment of sore throat: a randomised, double-blind, placebo-controlled study in UK general practice centres. | International journal of clinical practice 20020301 |
| Prediction of poly(ethylene) glycol-drug eutectic compositions using an index based on the van't Hoff equation. | Pharmaceutical research 20020301 |
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| Beneficial effects of NO-releasing derivative of flurbiprofen (HCT-1026) in rat model of vascular injury and restenosis. | Arteriosclerosis, thrombosis, and vascular biology 20020201 |
| Molecular modelling of the differential interaction between several non-steroidal anti-inflammatory drugs and human prostaglandin endoperoxide H synthase-2 (h-PGHS-2). | Journal of molecular graphics & modelling 20020101 |
| Nitric-oxide releasing molecules: a new class of drugs with several major indications. | Current pharmaceutical design 20020101 |
| The effect of nonsteroidal antiinflammatory drugs ibuprofen, flurbiprofen, and diclofenac on in vitro and in vivo growth of mouse fibrosarcoma. | Cancer investigation 20020101 |
| Therapeutic utility of aspirin in the ApcMin/+ murine model of colon carcinogenesis. | BMC cancer 20020101 |
| Mechanism of in vitro release kinetics of flurbiprofen loaded ethylcellulose micropellets. | Acta poloniae pharmaceutica 20020101 |
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| Cyclooxygenase and 5-lipoxygenase inhibitors protect against mononuclear phagocyte neurotoxicity. | Neurobiology of aging 20020101 |
| Separation and determination of diastereomeric flurbiprofen acyl glucuronides in human urine by LC/ESI-MS with a simple column-switching technique. | Drug metabolism and pharmacokinetics 20020101 |
| Elimination profiles of flurbiprofen and its metabolites in equine urine for doping analysis. | Talanta 20011224 |
| Estimation of acute flurbiprofen and ketoprofen toxicity in rat gastric mucosa at therapy-relevant doses. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20011201 |
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| Validation of subcutaneous microdialysis sampling for pharmacokinetic studies of flurbiprofen in the rat. | Journal of pharmaceutical sciences 20011101 |
| Retrospective analysis of drug-induced urticaria and angioedema: a survey of 2287 patients. | Immunopharmacology and immunotoxicology 20011101 |
| Interactive roles of superoxide and inducible nitric oxide synthase in rat intestinal injury provoked by non-steroidal anti-inflammatory drugs. | European journal of pharmacology 20011019 |
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| Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20011015 |
| Dominant role of an endothelium-derived hyperpolarizing factor (EDHF)-like vasodilator in the ciliary vascular bed of the bovine isolated perfused eye. | British journal of pharmacology 20011001 |
| Cyclooxygenase-independent actions of cyclooxygenase inhibitors. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20011001 |
| Measurement of ketoprofen in horse urine using gas chromatography-mass spectrometry. | Journal of veterinary pharmacology and therapeutics 20011001 |
| The effect of flurbiprofen and tiaprofenic acid on serum cytokine levels of patients with osteoarthrosis. | Acta orthopaedica Scandinavica 20011001 |
| Nicotine-induced contraction in the rat coronary artery: possible involvement of the endothelium, reactive oxygen species and COX-1 metabolites. | Journal of cardiovascular pharmacology 20011001 |
| Effect of flurbiprofen on hind-limb suspension-induced bone loss. | Aviation, space, and environmental medicine 20010901 |
| Comparative evaluation of corneal epithelial permeability after the use of diclofenac 0.1% and flurbiprofen 0.03% after phacoemulsification. | Journal of cataract and refractive surgery 20010901 |
| Inhibition of bone resorption in vitro and prevention of ovariectomy-induced bone loss in vivo by flurbiprofen nitroxybutylester (HCT1026). | Arthritis and rheumatism 20010901 |
| Synthesis and receptor docking studies of N-substituted indole-2-carboxylic acid esters as a search for COX-2 selective enzyme inhibitors. | European journal of medicinal chemistry 20010901 |
| Palladium-catalyzed alpha-arylation of esters. | Journal of the American Chemical Society 20010822 |
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| Bradykinin-induced nociceptor sensitization to heat is mediated by cyclooxygenase products in isolated rat skin. | The European journal of neuroscience 20010701 |
| Peroxidase self-inactivation in prostaglandin H synthase-1 pretreated with cyclooxygenase inhibitors or substituted with mangano protoporphyrin IX. | The Journal of biological chemistry 20010608 |
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| Proapoptotic anti-inflammatory drugs. | Urology 20010401 |
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| Review: uveitis and immunosuppressive drugs. | Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20010401 |
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| Relative contributions of CYP2C9 and 2C19 to phenytoin 4-hydroxylation in vitro: inhibition by sulfaphenazole, omeprazole, and ticlopidine. | European journal of clinical pharmacology 20010401 |
| Modulation of prostaglandin H synthase activity by conjugated linoleic acid (CLA) and specific CLA isomers. | Lipids 20010401 |
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| Interactions of inflammatory mediators stimulating release of calcitonin gene-related peptide, substance P and prostaglandin E(2) from isolated rat skin. | Neuropharmacology 20010301 |
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| Perioperative intravenous flurbiprofen reduces postoperative pain after abdominal hysterectomy. | Canadian journal of anaesthesia = Journal canadien d'anesthesie 20010301 |
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| Aortic hyporeactivity to norepinephrine induced by lipopolysaccharide in cirrhotic rats: beneficial effects of a non-steroidal anti-inflammatory drug coupled with a nitric oxide donor. | Journal of gastroenterology and hepatology 20010101 |
| Risk of upper gastrointestinal bleeding and perforation associated with low-dose aspirin as plain and enteric-coated formulations. | BMC clinical pharmacology 20010101 |
| Using evidence from different sources: an example using paracetamol 1000 mg plus codeine 60 mg. | BMC medical research methodology 20010101 |
| Directed control of electroosmotic flow in nonaqueous electrolytes using poly(ethylene glycol) coated capillaries. | Electrophoresis 20010101 |
| Screening procedure for detection of non-steroidal anti-inflammatory drugs and their metabolites in urine as part of a systematic toxicological analysis procedure for acidic drugs and poisons by gas chromatography-mass spectrometry after extractive methylation. | Journal of analytical toxicology 20010101 |
| Protection by aspirin of indomethacin-induced small intestinal damage in rats: mediation by salicylic acid. | Journal of physiology, Paris 20010101 |
| Intracrevicular application of 0.3% Flurbiprofen gel and 0.3% Triclosan gel as anti inflammatory agent. A comparative clinical study. | Indian journal of dental research : official publication of Indian Society for Dental Research 20010101 |
| Prostaglandin synthesis inhibitor improves hypotension during normothermic cardiopulmonary bypass. | ASAIO journal (American Society for Artificial Internal Organs : 1992) 20010101 |
| Effects of epidural fentanyl and intravenous flurbiprofen for visceral pain during cesarean section under spinal anesthesia. | Journal of anesthesia 20010101 |
| Effect of endogenous and exogenous prostaglandin E(2) on interleukin-1 beta-induced cyclooxygenase-2 expression in human airway smooth-muscle cells. | American journal of respiratory and critical care medicine 20001201 |
| Cyclooxygenase-2 expression in lipopolysaccharide-stimulated human monocytes is modulated by cyclic AMP, prostaglandin E(2), and nonsteroidal anti-inflammatory drugs. | Biochemical and biophysical research communications 20001130 |
| Selective inhibition of cyclooxygenase-2 suppresses growth and induces apoptosis in human esophageal adenocarcinoma cells. | Cancer research 20001015 |
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| Inhibition of pilocarpine-induced aqueous humor flare, hypotony, and miosis by topical administration of anti-inflammatory and anesthetic drugs to dogs. | American journal of veterinary research 19980401 |
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| Aspirin-like drugs can protect human T lymphocytes against benzoquinone cytotoxicity: evidence for a NAD(P)H:quinone reductase-dependent mechanism. | Archives of toxicology 19950101 |
| A recombinant phenobarbital-inducible rat liver UDP-glucuronosyltransferase (UDP-glucuronosyltransferase 2B1) stably expressed in V79 cells catalyzes the glucuronidation of morphine, phenols, and carboxylic acids. | Molecular pharmacology 19940101 |
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