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5154-02-9 | 1,5-ISOQUINOLINEDIOL
CAS No: 5154-02-9 Catalog No: AG00DE9E MDL No:MFCD00006900
Product Description
Catalog Number:
AG00DE9E
Chemical Name:
1,5-ISOQUINOLINEDIOL
CAS Number:
5154-02-9
Molecular Formula:
C9H7NO2
Molecular Weight:
161.1574
MDL Number:
MFCD00006900
IUPAC Name:
5-hydroxy-2H-isoquinolin-1-one
InChI:
InChI=1S/C9H7NO2/c11-8-3-1-2-7-6(8)4-5-10-9(7)12/h1-5,11H,(H,10,12)
InChI Key:
LFUJIPVWTMGYDG-UHFFFAOYSA-N
SMILES:
Oc1cccc2c1ccnc2O
NSC Number:
65585
Properties
Complexity:
225
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
161.048g/mol
Formal Charge:
0
Heavy Atom Count:
12
Hydrogen Bond Acceptor Count:
2
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
161.16g/mol
Monoisotopic Mass:
161.048g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
49.3A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1
Literature
| Title | Journal |
|---|---|
| Bone marrow expression of poly(ADP-ribose) polymerase underlies diabetic neuropathy via hematopoietic-neuronal cell fusion. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20120101 |
| Small fragment homologous replacement: evaluation of factors influencing modification efficiency in an eukaryotic assay system. | PloS one 20120101 |
| Potential role of poly(ADP-ribose) polymerase (PARP) activation in methotrexate-induced nephrotoxicity and tubular apoptosis. | International journal of toxicology 20120101 |
| PARP inhibition alleviates diabetes-induced systemic oxidative stress and neural tissue 4-hydroxynonenal adduct accumulation: correlation with peripheral nerve function. | Free radical biology & medicine 20110515 |
| A 3-D microfluidic combinatorial cell array. | Biomedical microdevices 20110201 |
| Low doses of 3-aminobenzamide, a poly(ADP-ribose) polymerase inhibitor, stimulate angiogenesis by regulating expression of urokinase type plasminogen activator and matrix metalloprotease 2. | Vascular cell 20110101 |
| Butyrate-induced cell death and differentiation are associated with distinct patterns of ROS in HT29-derived human colon cancer cells. | Digestive diseases and sciences 20100401 |
| Role of the poly(ADP-ribose)polymerase activity in vancomycin-induced renal injury. | Toxicology letters 20100201 |
| A novel PARP inhibitor L-2286 in a rat model of impact acceleration head injury: an immunohistochemical and behavioral study. | International journal of molecular sciences 20100101 |
| Poly(Adenosine 5'-diphosphate-ribose) polymerase inhibition counteracts multiple manifestations of experimental type 1 diabetic nephropathy. | Endocrinology 20091201 |
| Reactive oxygen species-dependent activation of Bax and poly(ADP-ribose) polymerase-1 is required for mitochondrial cell death induced by triterpenoid pristimerin in human cervical cancer cells. | Molecular pharmacology 20091001 |
| Aldosterone-induced endothelial dysfunction of rat aorta: role of poly(ADP-ribose) activation. | Journal of the renin-angiotensin-aldosterone system : JRAAS 20090901 |
| Poly(ADP-ribose)polymerase inhibition counteracts cataract formation and early retinal changes in streptozotocin-diabetic rats. | Investigative ophthalmology & visual science 20090401 |
| Inhibition of poly(ADP-ribose) polymerase activity affects its subcellular localization and DNA strand break rejoining. | Acta biochimica Polonica 20090101 |
| PARP inhibition reduces acute colonic inflammation in rats. | European journal of pharmacology 20070601 |
| Poly(ADP-ribose)polymerase inhibition decreases angiogenesis. | Biochemical and biophysical research communications 20061201 |
| Poly(ADP-ribose) polymerase inhibition alleviates experimental diabetic sensory neuropathy. | Diabetes 20060601 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| Inhibition of NOS-2 induction in LPS-stimulated J774.2 cells by 1, 5-isoquinolinediol, an inhibitor of PARP. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20060301 |
| Identification of poly(ADP-ribose)polymerase-1 and Ku70/Ku80 as transcriptional regulators of S100A9 gene expression. | BMC molecular biology 20060101 |
| Mitochondrial impairment induced by poly(ADP-ribose) polymerase-1 activation in cortical neurons after oxygen and glucose deprivation. | Journal of neurochemistry 20051001 |
| Low-dose poly(ADP-ribose) polymerase inhibitor-containing combination therapies reverse early peripheral diabetic neuropathy. | Diabetes 20050501 |
| Inhibitors of poly (ADP-ribose) polymerase ameliorate myocardial reperfusion injury by modulation of activator protein-1 and neutrophil infiltration. | Shock (Augusta, Ga.) 20050301 |
| Caspase-independent cell death by arsenic trioxide in human cervical cancer cells: reactive oxygen species-mediated poly(ADP-ribose) polymerase-1 activation signals apoptosis-inducing factor release from mitochondria. | Cancer research 20041215 |
| Caspase-1 and poly (ADP-ribose) polymerase inhibitors may protect against peroxynitrite-induced neurotoxicity independent of their enzyme inhibitor activity. | The European journal of neuroscience 20041001 |
| Neuroprotective effect of peroxynitrite decomposition catalyst and poly(adenosine diphosphate-ribose) polymerase inhibitor alone and in combination in rats with focal cerebral ischemia. | Journal of neurosurgery 20041001 |
| Poly(ADP-ribose) polymerase inhibitors counteract diabetes- and hypoxia-induced retinal vascular endothelial growth factor overexpression. | International journal of molecular medicine 20040701 |
| Role of poly(ADP-ribose) polymerase activation in diabetic neuropathy. | Diabetes 20040301 |
| Effect of poly(ADP-ribose) polymerase inhibitors on oxidative stress evoked hydroxyl radical level and macromolecules oxidation in cell free system of rat brain cortex. | Neuroscience letters 20040206 |
| Activation of poly(adenosine diphosphate-ribose) polymerase in mouse tumors treated by photodynamic therapy. | Photochemistry and photobiology 20031001 |
| Diabetes-induced overexpression of endothelin-1 and endothelin receptors in the rat renal cortex is mediated via poly(ADP-ribose) polymerase activation. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030801 |
| Poly(ADP-ribose) polymerase-1 is a positive regulator of the p53-mediated G1 arrest response following ionizing radiation. | The Journal of biological chemistry 20030523 |
| Inhibitors of poly (ADP-ribose) polymerase modulate signal transduction pathways in colitis. | European journal of pharmacology 20030523 |
| The effect of poly (adenosine diphosphate-ribose) polymerase inhibitors on biochemical changes in testicular ischemia-reperfusion injury. | The Journal of urology 20030501 |
| 1,5-isoquinolinediol increases the frequency of gene targeting by homologous recombination in mouse fibroblasts. | Biochemistry and cell biology = Biochimie et biologie cellulaire 20030201 |
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
| All trans retinoic acid induces apoptosis in acute promyelocytic NB4 cells when combined with isoquinolinediol, a poly(ADP-ribose) polymerase inhibitor. | Leukemia research 20000401 |
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