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50892-23-4 | WY-14643
CAS No: 50892-23-4 Catalog No: AG003VBY MDL No:MFCD00191335
Product Description
Catalog Number:
AG003VBY
Chemical Name:
WY-14643
CAS Number:
50892-23-4
Molecular Formula:
C14H14ClN3O2S
Molecular Weight:
323.7979
MDL Number:
MFCD00191335
IUPAC Name:
2-[4-chloro-6-(2,3-dimethylanilino)pyrimidin-2-yl]sulfanylacetic acid
InChI:
InChI=1S/C14H14ClN3O2S/c1-8-4-3-5-10(9(8)2)16-12-6-11(15)17-14(18-12)21-7-13(19)20/h3-6H,7H2,1-2H3,(H,19,20)(H,16,17,18)
InChI Key:
SZRPDCCEHVWOJX-UHFFFAOYSA-N
SMILES:
OC(=O)CSc1nc(cc(n1)Cl)Nc1cccc(c1C)C
UNII:
86C4MRT55A
NSC Number:
310038
Properties
Complexity:
361
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
323.05g/mol
Formal Charge:
0
Heavy Atom Count:
21
Hydrogen Bond Acceptor Count:
6
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
323.795g/mol
Monoisotopic Mass:
323.05g/mol
Rotatable Bond Count:
5
Topological Polar Surface Area:
100A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4.2
Literature
| Title | Journal |
|---|---|
| Expression of cytochrome P450 epoxygenases and soluble epoxide hydrolase is regulated by hypolipidemic drugs in dose-dependent manner. | Toxicology and applied pharmacology 20180915 |
| PPARα-independent transcriptional targets of perfluoroalkyl acids revealed by transcript profiling. | Toxicology 20170715 |
| The induction of cytochrome P450 2E1 by ethanol leads to the loss of synaptic proteins via PPARα down-regulation. | Toxicology 20170615 |
| Role of the lipid-regulated NF-κB/IL-6/STAT3 axis in alpha-naphthyl isothiocyanate-induced liver injury. | Archives of toxicology 20170501 |
| Antidiabetic effect of SN158 through PPARα/γ dual activation in ob/ob mice. | Chemico-biological interactions 20170425 |
| Perfluoroalkyl acids-induced liver steatosis: Effects on genes controlling lipid homeostasis. | Toxicology 20170301 |
| Discriminating between adaptive and carcinogenic liver hypertrophy in rat studies using logistic ridge regression analysis of toxicogenomic data: The mode of action and predictive models. | Toxicology and applied pharmacology 20170301 |
| Activation of the Constitutive Androstane Receptor by Monophthalates. | Chemical research in toxicology 20161017 |
| Activation of peroxisome proliferator-activated receptor α ameliorates perfluorododecanoic acid-induced production of reactive oxygen species in rat liver. | Archives of toxicology 20160601 |
| Effects of Crude Oil/Dispersant Mixture and Dispersant Components on PPARγ Activity in Vitro and in Vivo: Identification of Dioctyl Sodium Sulfosuccinate (DOSS; CAS #577-11-7) as a Probable Obesogen. | Environmental health perspectives 20160101 |
| Transcriptome analyses demonstrate that Peroxisome Proliferator-Activated Receptor α (PPARα) activity of an ultraviolet absorber, 2-(2'-hydroxy-3',5'-di-tert-butylphenyl)benzotriazole, as possible mechanism of their toxicity and the gender differences. | The Journal of toxicological sciences 20160101 |
| A novel toxicogenomics-based approach to categorize (non-)genotoxic carcinogens. | Archives of toxicology 20151201 |
| Activation of sterol regulatory element-binding proteins in mice exposed to perfluorooctanoic acid for 28 days. | Archives of toxicology 20150901 |
| Oxidative Stress Mechanisms Do Not Discriminate between Genotoxic and Nongenotoxic Liver Carcinogens. | Chemical research in toxicology 20150817 |
| Evidence that the capacity of nongenotoxic carcinogens to induce oxidative stress is subject to marked variability. | Toxicological sciences : an official journal of the Society of Toxicology 20150501 |
| Identification of modulators of the nuclear receptor peroxisome proliferator-activated receptor α (PPARα) in a mouse liver gene expression compendium. | PloS one 20150101 |
| Identification of chemical modulators of the constitutive activated receptor (CAR) in a gene expression compendium. | Nuclear receptor signaling 20150101 |
| Role of the ubiquitin-proteasome system in cardiac dysfunction of adipose triglyceride lipase-deficient mice. | Journal of molecular and cellular cardiology 20141201 |
| Fish oil and fenofibrate prevented phosphorylation-dependent hepatic sortilin 1 degradation in Western diet-fed mice. | The Journal of biological chemistry 20140808 |
| Sargahydroquinoic acid inhibits TNFα-induced AP-1 and NF-κB signaling in HaCaT cells through PPARα activation. | Biochemical and biophysical research communications 20140808 |
| Resveratrol and its metabolites bind to PPARs. | Chembiochem : a European journal of chemical biology 20140526 |
| Evaluating the additivity of perfluoroalkyl acids in binary combinations on peroxisome proliferator-activated receptor-α activation. | Toxicology 20140227 |
| Genomic models of short-term exposure accurately predict long-term chemical carcinogenicity and identify putative mechanisms of action. | PloS one 20140101 |
| PPARα-mediated responses in human adult liver stem cells: In vivo/in vitro and cross-species comparisons. | The Journal of steroid biochemistry and molecular biology 20131101 |
| Normalization strategies for gene expression studies by real-time PCR in a marine fish species, Scophthalmus maximus. | Marine genomics 20130601 |
| Identification of transcription factors and coactivators affected by dibutylphthalate interactions in fetal rat testes. | Toxicological sciences : an official journal of the Society of Toxicology 20130401 |
| Detection of genotoxic and non-genotoxic carcinogens in Xpc(-/-)p53(+/-) mice. | Toxicology and applied pharmacology 20130115 |
| Xenobiotic-induced hepatocyte proliferation associated with constitutive active/androstane receptor (CAR) or peroxisome proliferator-activated receptor α (PPARα) is enhanced by pregnane X receptor (PXR) activation in mice. | PloS one 20130101 |
| Perfluorooctanoic acid induced-developmental cardiotoxicity: are peroxisome proliferator activated receptor α (PPARα) and bone morphorgenic protein 2 (BMP2) pathways involved? | Journal of toxicology and environmental health. Part A 20130101 |
| Wy14643 improves vascular function in the aorta of the spontaneously hypertensive rat mainly by activating peroxisome proliferator-activated receptors alpha. | European journal of pharmacology 20121205 |
| APOA5 gene expression in the human intestinal tissue and its response to in vitro exposure to fatty acid and fibrate. | Nutrition, metabolism, and cardiovascular diseases : NMCD 20120901 |
| Comparison of hepatocarcinogen-induced gene expression profiles in conventional primary rat hepatocytes with in vivo rat liver. | Archives of toxicology 20120901 |
| Assessment of possible carcinogenicity of oxyfluorfen to humans using mode of action analysis of rodent liver effects. | Toxicological sciences : an official journal of the Society of Toxicology 20120801 |
| PPAR-alpha activation as a preconditioning-like intervention in rats in vivo confers myocardial protection against acute ischaemia-reperfusion injury: involvement of PI3K-Akt. | Canadian journal of physiology and pharmacology 20120801 |
| Nuclear receptors agonists exert opposing effects on the inflammation dependent survival of breast cancer stem cells. | Cell death and differentiation 20120701 |
| Peroxisome proliferator-activated receptor alpha induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity. | Hepatology (Baltimore, Md.) 20120701 |
| Topical application of PPARα (but not β/δ or γ) suppresses atopic dermatitis in NC/Nga mice. | Allergy 20120701 |
| Total synthesis and dual PPARα/γ agonist effects of amorphastilbol and its synthetic derivatives. | Bioorganic & medicinal chemistry letters 20120615 |
| Cytokine production by infrapatellar fat pad can be stimulated by interleukin 1β and inhibited by peroxisome proliferator activated receptor α agonist. | Annals of the rheumatic diseases 20120601 |
| Co-treatment with retinyl retinoate and a PPARα agonist reduces retinoid dermatitis. | International journal of dermatology 20120601 |
| Detailed transcriptomics analysis of the effect of dietary fatty acids on gene expression in the heart. | Physiological genomics 20120319 |
| Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptors α/γ dual agonists. | Bioorganic & medicinal chemistry 20120315 |
| Hepatocellular hypertrophy and cell proliferation in Sprague-Dawley rats from dietary exposure to potassium perfluorooctanesulfonate results from increased expression of xenosensor nuclear receptors PPARα and CAR/PXR. | Toxicology 20120311 |
| PPARα and PPARγ regulate the nucleoside transporter hENT1. | Biochemical and biophysical research communications 20120309 |
| Peroxisome proliferator-activated receptor-α agonist, Wy 14,643, improves metabolic indices, steatosis and ballooning in diabetic mice with non-alcoholic steatohepatitis. | Journal of gastroenterology and hepatology 20120201 |
| Genomic biomarkers of phthalate-induced male reproductive developmental toxicity: a targeted RT-PCR array approach for defining relative potency. | Toxicological sciences : an official journal of the Society of Toxicology 20120201 |
| Using functional signatures to identify repositioned drugs for breast, myelogenous leukemia and prostate cancer. | PLoS computational biology 20120201 |
| Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity. | Journal of medicinal chemistry 20120112 |
| Cardiac dysfunction in adipose triglyceride lipase deficiency: treatment with a PPARα agonist. | British journal of pharmacology 20120101 |
| Fine metabolic regulation in ruminants via nutrient-gene interactions: saturated long-chain fatty acids increase expression of genes involved in lipid metabolism and immune response partly through PPAR-α activation. | The British journal of nutrition 20120101 |
| Fenofibrate down-regulates renal OCT2-mediated organic cation transport via PPARα-independent pathways. | Drug metabolism and pharmacokinetics 20120101 |
| Combining ZHENG Theory and High-Throughput Expression Data to Predict New Effects of Chinese Herbal Formulae. | Evidence-based complementary and alternative medicine : eCAM 20120101 |
| Organotypic modeling of human keratinocyte response to peroxisome proliferators. | Cells, tissues, organs 20120101 |
| Proteome analysis identified the PPARγ ligand 15d-PGJ2 as a novel drug inhibiting melanoma progression and interfering with tumor-stroma interaction. | PloS one 20120101 |
| In Vitro and In Vivo Characterizations of Chiglitazar, a Newly Identified PPAR Pan-Agonist. | PPAR research 20120101 |
| Tertiary alkylamines as nucleophiles in substitution reactions at heteroaromatic halide during the synthesis of the highly potent pirinixic acid derivative 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS-121). | Molecules (Basel, Switzerland) 20111205 |
| Human embryonic stem cell derived hepatocyte-like cells as a tool for in vitro hazard assessment of chemical carcinogenicity. | Toxicological sciences : an official journal of the Society of Toxicology 20111201 |
| Adiponectin reduces connective tissue growth factor in human hepatocytes which is already induced in non-fibrotic non-alcoholic steatohepatitis. | Experimental and molecular pathology 20111201 |
| Efficacy of combined peroxisome proliferator-activated receptor-α ligand and glucocorticoid therapy in a murine model of atopic dermatitis. | The Journal of investigative dermatology 20110901 |
| PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation. | Biochimica et biophysica acta 20110801 |
| A pirinixic acid derivative (LP105) inhibits murine 5-lipoxygenase activity and attenuates vascular remodelling in a murine model of aortic aneurysm. | British journal of pharmacology 20110801 |
| Peroxisome proliferator activated receptor alpha activation decreases inflammatory and destructive responses in osteoarthritic cartilage. | Osteoarthritis and cartilage 20110701 |
| Differential regulation of bovine pyruvate carboxylase promoters by fatty acids and peroxisome proliferator-activated receptor-α agonist. | Journal of dairy science 20110701 |
| Effects of chronic systemic treatment with peroxisome proliferator-activated receptor α activators on neuroinflammation induced by intracerebral injection of lipopolysaccharide in adult mice. | Neuroscience research 20110601 |
| 20-Hydroxyeicosatetraenoic acid inhibits ATP-induced COX-2 expression via peroxisome proliferator activator receptor-α in vascular smooth muscle cells. | British journal of pharmacology 20110601 |
| Revisiting glitazars: thiophene substituted oxazole containing α-ethoxy phenylpropanoic acid derivatives as highly potent PPARα/γ dual agonists devoid of adverse effects in rodents. | Bioorganic & medicinal chemistry letters 20110515 |
| Pharmacophore modeling and virtual screening for novel acidic inhibitors of microsomal prostaglandin E₂ synthase-1 (mPGES-1). | Journal of medicinal chemistry 20110512 |
| A role for the peroxisomal 3-ketoacyl-CoA thiolase B enzyme in the control of PPARα-mediated upregulation of SREBP-2 target genes in the liver. | Biochimie 20110501 |
| Lack of PPARα exacerbates lipopolysaccharide-induced liver toxicity through STAT1 inflammatory signaling and increased oxidative/nitrosative stress. | Toxicology letters 20110410 |
| PPARα agonist prevented the apoptosis induced by glucose and fatty acid in neonatal cardiomyocytes. | Journal of endocrinological investigation 20110401 |
| Fenofibrate suppresses microvascular inflammation and apoptosis through adenosine monophosphate-activated protein kinase activation. | Metabolism: clinical and experimental 20110401 |
| Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors. | Biological psychiatry 20110401 |
| A novel class of dual mPGES-1/5-LO inhibitors based on the α-naphthyl pirinixic acid scaffold. | Bioorganic & medicinal chemistry letters 20110301 |
| Effect of structurally constrained oxime-ether linker on PPAR subtype selectivity: Discovery of a novel and potent series of PPAR-pan agonists. | Bioorganic & medicinal chemistry 20110115 |
| 26-Week carcinogenicity study of di-isodecyl phthalate by dietary administration to CB6F1-rasH2 transgenic mice. | Archives of toxicology 20110101 |
| Activation of peroxisome proliferator-activated receptor α in megakaryocytes reduces platelet-derived growth factor-BB in platelets. | Journal of atherosclerosis and thrombosis 20110101 |
| Peroxisome proliferator-activated receptor activators protect sebocytes from apoptosis: a new treatment modality for acne? | The British journal of dermatology 20110101 |
| The peroxisome proliferator-activated receptor (PPAR) alpha agonist fenofibrate maintains bone mass, while the PPAR gamma agonist pioglitazone exaggerates bone loss, in ovariectomized rats. | BMC endocrine disorders 20110101 |
| Clofibrate relaxes the longitudinal smooth muscle of the mouse distal colon through calcium-mediated desensitisation of contractile machinery. | Pharmacology 20110101 |
| Two thiophenes compounds are partial peroxisome proliferator-activated receptor α/γ dual agonists. | Biological & pharmaceutical bulletin 20110101 |
| Activation of peroxisome proliferator activated receptor alpha ameliorates ethanol induced steatohepatitis in mice. | Lipids in health and disease 20110101 |
| Evaluation of an in vitro toxicogenetic mouse model for hepatotoxicity. | Toxicology and applied pharmacology 20101215 |
| PPARalpha-dependent activation of cell cycle control and DNA repair genes in hepatic nonparenchymal cells. | Toxicological sciences : an official journal of the Society of Toxicology 20101201 |
| Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. | Toxicological sciences : an official journal of the Society of Toxicology 20101201 |
| Fenofibrate but not fenofibric acid inhibits 11beta-hydroxysteroid dehydrogenase 1 in C2C12 myotubes. | Molecular and cellular biochemistry 20101101 |
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
| Functionalization of fatty acid mimetics for solid-phase coupling and subsequent target identification. | Archiv der Pharmazie 20101101 |
| Hepatocellular hypertrophy and cell proliferation in Sprague-Dawley rats following dietary exposure to ammonium perfluorooctanoate occurs through increased activation of the xenosensor nuclear receptors PPARα and CAR/PXR. | Archives of toxicology 20101001 |
| PPARα contributes to colonic protection in mice with DSS-induced colitis. | International immunopharmacology 20101001 |
| Adiponectin-mediated heme oxygenase-1 induction protects against iron-induced liver injury via a PPARα dependent mechanism. | The American journal of pathology 20101001 |
| Effect of prenatal peroxisome proliferator-activated receptor alpha (PPARalpha) agonism on postnatal development. | Toxicology 20100930 |
| Aberrant hepatic TRIB3 gene expression in insulin-resistant obese humans. | Diabetologia 20100901 |
| Peroxisome proliferation activation receptor alpha modulation of Ca2+-regulated exocytosis via arachidonic acid in guinea-pig antral mucous cells. | Experimental physiology 20100801 |
| Fenofibrate induces effective apoptosis in mantle cell lymphoma by inhibiting the TNFalpha/NF-kappaB signaling axis. | Leukemia 20100801 |
| Pravastatin attenuates carboplatin-induced nephrotoxicity in rodents via peroxisome proliferator-activated receptor alpha-regulated heme oxygenase-1. | Molecular pharmacology 20100701 |
| Evaluation of in vivo liver genotoxic potential of Wy-14,643 and piperonyl butoxide in rats subjected to two-week repeated oral administration. | Archives of toxicology 20100601 |
| Deciphering diseases and biological targets for environmental chemicals using toxicogenomics networks. | PLoS computational biology 20100501 |
| The effects of a PPARalpha agonist on myocardial damage in obese diabetic mice with heart failure. | International heart journal 20100501 |
| Rational design of a pirinixic acid derivative that acts as subtype-selective PPARgamma modulator. | Bioorganic & medicinal chemistry letters 20100415 |
| Validation of an in vitro screening test for predicting the tumor promoting potential of chemicals based on gene expression. | Toxicology in vitro : an international journal published in association with BIBRA 20100401 |
| Control of steroid 21-oic acid synthesis by peroxisome proliferator-activated receptor alpha and role of the hypothalamic-pituitary-adrenal axis. | The Journal of biological chemistry 20100305 |
| The molecular pharmacology and in vivo activity of 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS121), a dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase. | The Journal of pharmacology and experimental therapeutics 20100301 |
| Impacts of different promoters on the mammalian one-hybrid assay for detecting nuclear receptor agonists. | Analytical and bioanalytical chemistry 20100301 |
| Short-term therapy with peroxisome proliferation-activator receptor-alpha agonist Wy-14,643 protects murine fatty liver against ischemia-reperfusion injury. | Hepatology (Baltimore, Md.) 20100301 |
| Enantiomer separation and indirect chromatographic absolute configuration prediction of chiral pirinixic acid derivatives: Limitations of polysaccharide-type chiral stationary phases in comparison to chiral anion-exchangers. | Journal of chromatography. A 20100212 |
| Design, synthesis, and docking studies of novel benzimidazoles for the treatment of metabolic syndrome. | Journal of medicinal chemistry 20100211 |
| Transcription coactivator PBP/MED1-deficient hepatocytes are not susceptible to diethylnitrosamine-induced hepatocarcinogenesis in the mouse. | Carcinogenesis 20100201 |
| The pollutant diethylhexyl phthalate regulates hepatic energy metabolism via species-specific PPARalpha-dependent mechanisms. | Environmental health perspectives 20100201 |
| Induction of RIP-2 kinase by proinflammatory cytokines is mediated via NF-kappaB signaling pathways and involves a novel feed-forward regulatory mechanism. | Molecular and cellular biochemistry 20100101 |
| Glucans from the Caripia montagnei mushroom present anti-inflammatory activity. | International immunopharmacology 20100101 |
| Characterization of peroxisome proliferator-activated receptor alpha--independent effects of PPARalpha activators in the rodent liver: di-(2-ethylhexyl) phthalate also activates the constitutive-activated receptor. | Toxicological sciences : an official journal of the Society of Toxicology 20100101 |
| Iridoids from Fraxinus excelsior with adipocyte differentiation-inhibitory and PPARalpha activation activity. | Journal of natural products 20100101 |
| Analysis of the heat shock response in mouse liver reveals transcriptional dependence on the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha). | BMC genomics 20100101 |
| Peroxisome proliferator-activated receptor alpha (PPARalpha) agonists induce constitutive androstane receptor (CAR) and cytochrome P450 2B in rat primary hepatocytes. | Drug metabolism and pharmacokinetics 20100101 |
| PPARα in Obesity: Sex Difference and Estrogen Involvement. | PPAR research 20100101 |
| WY-14 643, a selective PPAR{alpha} agonist, induces proinflammatory and proangiogenic responses in human ocular cells. | International journal of toxicology 20100101 |
| PRIC295, a Nuclear Receptor Coactivator, Identified from PPARα-Interacting Cofactor Complex. | PPAR research 20100101 |
| Gene Expression Profiling in Wild-Type and PPARα-Null Mice Exposed to Perfluorooctane Sulfonate Reveals PPARα-Independent Effects. | PPAR research 20100101 |
| Effects of the PPARα Agonist and Widely Used Antihyperlipidemic Drug Gemfibrozil on Hepatic Toxicity and Lipid Metabolism. | PPAR research 20100101 |
| Regulation of Proteome Maintenance Gene Expression by Activators of Peroxisome Proliferator-Activated Receptor α. | PPAR research 20100101 |
| Role of the nuclear receptors HNF4 alpha, PPAR alpha, and LXRs in the TNF alpha-mediated inhibition of human apolipoprotein A-I gene expression in HepG2 cells. | Biochemistry 20091222 |
| The absence of a functional peroxisome proliferator-activated receptor-alpha gene in mice enhances motor sensitizing effects of morphine, but not cocaine. | Neuroscience 20091201 |
| Organic cation/carnitine transporter OCTN3 is present in astrocytes and is up-regulated by peroxisome proliferators-activator receptor agonist. | The international journal of biochemistry & cell biology 20091201 |
| Peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) but not PPARalpha serves as a plasma free fatty acid sensor in liver. | Molecular and cellular biology 20091201 |
| 7-Hydroxy-benzopyran-4-one derivatives: a novel pharmacophore of peroxisome proliferator-activated receptor alpha and -gamma (PPARalpha and gamma) dual agonists. | Journal of medicinal chemistry 20091112 |
| PPARalpha ligand WY14643 reduced acute rejection after rat lung transplantation with the upregulation of IL-4, IL-10 and TGFbeta mRNA expression. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20091101 |
| Studies on induction of lamotrigine metabolism in transgenic UGT1 mice. | Xenobiotica; the fate of foreign compounds in biological systems 20091101 |
| A reexamination of the PPAR-alpha activation mode of action as a basis for assessing human cancer risks of environmental contaminants. | Environmental health perspectives 20091101 |
| Osthole, a potential antidiabetic agent, alleviates hyperglycemia in db/db mice. | Chemico-biological interactions 20091030 |
| New 2-aryloxy-3-phenyl-propanoic acids as peroxisome proliferator-activated receptors alpha/gamma dual agonists with improved potency and reduced adverse effects on skeletal muscle function. | Journal of medicinal chemistry 20091022 |
| Chronic treatment with the peroxisome proliferator-activated receptor alpha agonist Wy-14,643 attenuates myocardial respiratory capacity and contractile function. | Molecular and cellular biochemistry 20091001 |
| Mouse carnitine-acylcarnitine translocase (CACT) is transcriptionally regulated by PPARalpha and PPARdelta in liver cells. | Biochimica et biophysica acta 20091001 |
| Synergistic acceleration of thyroid hormone degradation by phenobarbital and the PPAR alpha agonist WY14643 in rat hepatocytes. | Toxicology and applied pharmacology 20091001 |
| Regulation of CYP4A expression by bezafibrate in primary culture of rat and human hepatocytes: interspecies difference and influence of N-acetylcysteine. | Toxicology in vitro : an international journal published in association with BIBRA 20091001 |
| Interference of alpha-alkyl-substituted pirinixic acid derivatives with neutrophil functions and signalling pathways. | European journal of pharmacology 20091001 |
| PPARalpha ligands cause lymphocyte depletion and cell cycle block and this is associated with augmented TRB3 and reduced Cyclin B1 expression. | Molecular immunology 20091001 |
| Glucose deprivation, oxidative stress and peroxisome proliferator-activated receptor-alpha (PPARA) cause peroxisome proliferation in preimplantation mouse embryos. | Reproduction (Cambridge, England) 20090901 |
| Fenofibrate differentially regulates plasminogen activator inhibitor-1 gene expression via adenosine monophosphate-activated protein kinase-dependent induction of orphan nuclear receptor small heterodimer partner. | Hepatology (Baltimore, Md.) 20090901 |
| Cross-talk between vitamin D receptor (VDR)- and peroxisome proliferator-activated receptor (PPAR)-signaling in melanoma cells. | Anticancer research 20090901 |
| Hepatic triacylglycerol hydrolysis regulates peroxisome proliferator-activated receptor alpha activity. | Journal of lipid research 20090801 |
| Oleoylethanolamide, a natural ligand for PPAR-alpha, inhibits insulin receptor signalling in HTC rat hepatoma cells. | Biochimica et biophysica acta 20090801 |
| Differential hepatic effects of perfluorobutyrate mediated by mouse and human PPAR-alpha. | Toxicological sciences : an official journal of the Society of Toxicology 20090701 |
| Cyanide-induced death of dopaminergic cells is mediated by uncoupling protein-2 up-regulation and reduced Bcl-2 expression. | Toxicology and applied pharmacology 20090701 |
| PPARgamma inhibits NF-kappaB-dependent transcriptional activation in skeletal muscle. | American journal of physiology. Endocrinology and metabolism 20090701 |
| Effects of WY-14643 on peroxisomal enzyme activity and hormone secretion in immortalized human trophoblast cells. | Biological & pharmaceutical bulletin 20090701 |
| Evidence for the involvement of xenobiotic-responsive nuclear receptors in transcriptional effects upon perfluoroalkyl acid exposure in diverse species. | Reproductive toxicology (Elmsford, N.Y.) 20090601 |
| The IkappaBalpha gene is a peroxisome proliferator-activated receptor cardiac target gene. | The FEBS journal 20090601 |
| Differentiated CaCo-2 cells as an in-vitro model to evaluate de-novo apolipoprotein A-I production in the small intestine. | European journal of gastroenterology & hepatology 20090601 |
| Gene expression profiling in rat liver treated with various hepatotoxic-compounds inducing coagulopathy. | The Journal of toxicological sciences 20090601 |
| Peroxisome proliferator-activated receptor alpha activation induces unfavourable changes in fatty acid composition of myocardial phospholipids. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20090601 |
| 15-deoxy-Delta(12,14)-prostaglandin J(2) inhibits fibrogenic response in human hepatoma cells. | Toxicology letters 20090522 |
| Effects of WY-14,643 on the phosphorylation and activation of AMP-dependent protein kinase. | Archives of biochemistry and biophysics 20090501 |
| Fatty acid amide hydrolase (FAAH) inhibition enhances memory acquisition through activation of PPAR-alpha nuclear receptors. | Learning & memory (Cold Spring Harbor, N.Y.) 20090501 |
| Mechanisms of resistance of hepatocyte retinoid X receptor alpha-null mice to WY-14,643-induced hepatocyte proliferation and cholestasis. | The Journal of biological chemistry 20090403 |
| Clinically relevant concentrations of di (2-ethylhexyl) phthalate (DEHP) uncouple cardiac syncytium. | Toxicology and applied pharmacology 20090401 |
| Cancer biomarker AKR1B10 and carbonyl metabolism. | Chemico-biological interactions 20090316 |
| Regulation of peroxisome proliferator-activated receptor-alpha by MDM2. | Toxicological sciences : an official journal of the Society of Toxicology 20090301 |
| Time-course comparison of xenobiotic activators of CAR and PPARalpha in mouse liver. | Toxicology and applied pharmacology 20090301 |
| PPAR-alpha activation protects the type 2 diabetic myocardium against ischemia-reperfusion injury: involvement of the PI3-Kinase/Akt and NO pathway. | American journal of physiology. Heart and circulatory physiology 20090301 |
| Activation of PPARalpha and PPARgamma reduces triacylglycerol synthesis in rat hepatoma cells by reduction of nuclear SREBP-1. | European journal of pharmacology 20090301 |
| Differential effects of in vivo PPAR alpha and gamma activation on fatty acid transport proteins expression and lipid content in rat liver. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20090301 |
| Topical peroxisome proliferator activated receptor activators accelerate postnatal stratum corneum acidification. | The Journal of investigative dermatology 20090201 |
| Rapid non-genomic regulation of Ca2+ signals and insulin secretion by PPAR alpha ligands in mouse pancreatic islets of Langerhans. | The Journal of endocrinology 20090201 |
| Optimization of an enzyme-linked immunosorbent assay to screen ligand of Peroxisome proliferator-activated receptor alpha. | Immunopharmacology and immunotoxicology 20090101 |
| Chronic, in vivo, PPARalpha activation prevents lipid overload in rat liver induced by high fat feeding. | Advances in medical sciences 20090101 |
| Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human. | PloS one 20090101 |
| Modulation of the hepatic fatty acid pool in peroxisomal 3-ketoacyl-CoA thiolase B-null mice exposed to the selective PPARalpha agonist Wy14,643. | Biochimie 20090101 |
| Prediction of pharmacological and xenobiotic responses to drugs based on time course gene expression profiles. | PloS one 20090101 |
| Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase. | Journal of medicinal chemistry 20081225 |
| Crystal structure of the peroxisome proliferator-activated receptor gamma (PPARgamma) ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic pocket could be exploited for drug design. | Journal of medicinal chemistry 20081225 |
| Effects of Wy14643 on hepatic ischemia reperfusion injury in rats. | World journal of gastroenterology 20081207 |
| PPARalpha activation and increased dietary lipid oppose thyroid hormone signaling and rescue impaired glucose-stimulated insulin secretion in hyperthyroidism. | American journal of physiology. Endocrinology and metabolism 20081201 |
| Synthesis and evaluation of a series of benzopyran derivatives as PPAR alpha/gamma agonists. | European journal of medicinal chemistry 20081101 |
| A PPARs cross-talk concertedly commits C6 glioma cells to oligodendrocytes and induces enzymes involved in myelin synthesis. | Journal of cellular physiology 20081101 |
| Peroxisome proliferator-activated receptor-alpha reduces inflammation and vascular leakage in a murine model of acute lung injury. | The European respiratory journal 20081101 |
| Activation of mouse and human peroxisome proliferator-activated receptor alpha by perfluoroalkyl acids of different functional groups and chain lengths. | Toxicological sciences : an official journal of the Society of Toxicology 20081101 |
| Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARalpha and PPARgamma agonist activity. | Bioorganic & medicinal chemistry 20081101 |
| Inflammatory pathways are activated during cardiomyocyte hypertrophy and attenuated by peroxisome proliferator-activated receptors PPARalpha and PPARdelta. | The Journal of biological chemistry 20081024 |
| Discovery of a highly orally bioavailable c-5-[6-(4-Methanesulfonyloxyphenyl)hexyl]-2-methyl-1,3-dioxane-r-2-carboxylic acid as a potent hypoglycemic and hypolipidemic agent. | Bioorganic & medicinal chemistry letters 20081015 |
| PPAR alpha, more than PPAR delta, mediates the hepatic and skeletal muscle alterations induced by the PPAR agonist GW0742. | Toxicological sciences : an official journal of the Society of Toxicology 20081001 |
| Effects of peroxisome proliferator-activated receptor alpha (PPARalpha) agonists on leucine-induced phosphorylation of translational targets in C2C12 cells. | Biochimica et biophysica acta 20081001 |
| Mechanisms of peroxisome proliferator-induced DNA hypomethylation in rat liver. | Mutation research 20080926 |
| Novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid. | Journal of medicinal chemistry 20080911 |
| Fish oil fed prior to ethanol administration prevents acute ethanol-induced fatty liver in mice. | Journal of hepatology 20080901 |
| A toxicogenomics approach for early assessment of potential non-genotoxic hepatocarcinogenicity of chemicals in rats. | Toxicology 20080819 |
| Partial resistance to peroxisome proliferator-activated receptor-alpha agonists in ZDF rats is associated with defective hepatic mitochondrial metabolism. | Diabetes 20080801 |
| Design and synthesis of novel oxazole containing 1,3-dioxane-2-carboxylic acid derivatives as PPAR alpha/gamma dual agonists. | Bioorganic & medicinal chemistry 20080801 |
| Characterization of Madin-Darby bovine kidney cell line for peroxisome proliferator-activated receptors: temporal response and sensitivity to fatty acids. | Journal of dairy science 20080701 |
| The in vivo gene expression signature of oxidative stress. | Physiological genomics 20080612 |
| Effect of peroxisome proliferator-activated receptor-alpha ligands in the interaction between adipocytes and macrophages in obese adipose tissue. | Obesity (Silver Spring, Md.) 20080601 |
| Monocarboxylate transporter (MCT)-1 is up-regulated by PPARalpha. | Biochimica et biophysica acta 20080601 |
| Gene profiling in the livers of wild-type and PPARalpha-null mice exposed to perfluorooctanoic acid. | Toxicologic pathology 20080601 |
| Comparative hepatic effects of perfluorooctanoic acid and WY 14,643 in PPAR-alpha knockout and wild-type mice. | Toxicologic pathology 20080601 |
| 1Alpha,25-dihydroxyvitamin D3 attenuates cyanide-induced neurotoxicity by inhibiting uncoupling protein-2 up-regulation. | Journal of neuroscience research 20080501 |
| Toxicogenomic dissection of the perfluorooctanoic acid transcript profile in mouse liver: evidence for the involvement of nuclear receptors PPAR alpha and CAR. | Toxicological sciences : an official journal of the Society of Toxicology 20080501 |
| In vivo imaging reveals selective peroxisome proliferator activated receptor modulator activity of the synthetic ligand 3-(1-(4-chlorobenzyl)-3-t-butylthio-5-isopropylindol-2-yl)-2,2-dimethylpropanoic acid (MK-886). | Molecular pharmacology 20080501 |
| Inhibiting wild-type and C299S mutant AKR1B10; a homologue of aldose reductase upregulated in cancers. | European journal of pharmacology 20080428 |
| PPARalpha: mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators. | Toxicology 20080403 |
| Peroxisome proliferator-activated receptor alpha regulates skin inflammation and humoral response in atopic dermatitis. | The Journal of allergy and clinical immunology 20080401 |
| Influence of dietary fatty acids on endocannabinoid and N-acylethanolamine levels in rat brain, liver and small intestine. | Biochimica et biophysica acta 20080401 |
| Nuclear receptor agonists improve insulin responsiveness in cultured cardiomyocytes through enhanced signaling and preserved cytoskeletal architecture. | Endocrinology 20080301 |
| Modulation of receptor phosphorylation contributes to activation of peroxisome proliferator activated receptor alpha by dehydroepiandrosterone and other peroxisome proliferators. | Molecular pharmacology 20080301 |
| Stereospecific synthesis and bio-activity of novel beta(3)-adrenoceptor agonists and inverse agonists. | Bioorganic & medicinal chemistry 20080301 |
| Alpha-alkyl substituted pirinixic acid derivatives as potent dual agonists of the peroxisome proliferator activated receptor alpha and gamma. | Archiv der Pharmazie 20080301 |
| Peroxisome proliferator-activated receptor alpha activation attenuated angiotensin type 1-mediated but enhanced angiotensin type 2-mediated hemodynamic effects to angiotensin II in the rat. | Journal of hypertension 20080301 |
| Down-regulation of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase by polyunsaturated fatty acids in hepatocytes is not mediated by PPARalpha. | European journal of nutrition 20080301 |
| The PPAR alpha-humanized mouse: a model to investigate species differences in liver toxicity mediated by PPAR alpha. | Toxicological sciences : an official journal of the Society of Toxicology 20080101 |
| Peroxisome proliferator-activated receptor alpha agonists enhance cardiomyogenesis of mouse ES cells by utilization of a reactive oxygen species-dependent mechanism. | Stem cells (Dayton, Ohio) 20080101 |
| Conflicting views on chemical carcinogenesis arising from the design and evaluation of rodent carcinogenicity studies. | Environmental health perspectives 20080101 |
| Placental implications of peroxisome proliferator-activated receptors in gestation and parturition. | PPAR research 20080101 |
| Effect of synthetic dietary triglycerides: a novel research paradigm for nutrigenomics. | PloS one 20080101 |
| PPARalpha-mediated effects of dietary lipids on intestinal barrier gene expression. | BMC genomics 20080101 |
| Activation of peroxisome proliferator-activated receptor alpha in human peripheral blood mononuclear cells reveals an individual gene expression profile response. | BMC genomics 20080101 |
| Peroxisome Proliferators-Activated Receptor (PPAR) Modulators and Metabolic Disorders. | PPAR research 20080101 |
| PPARalpha- and DEHP-Induced Cancers. | PPAR research 20080101 |
| Analgesic properties of oleoylethanolamide (OEA) in visceral and inflammatory pain. | Pain 20071215 |
| Time course investigation of PPARalpha- and Kupffer cell-dependent effects of WY-14,643 in mouse liver using microarray gene expression. | Toxicology and applied pharmacology 20071215 |
| Induction of nuclear translocation of constitutive androstane receptor by peroxisome proliferator-activated receptor alpha synthetic ligands in mouse liver. | The Journal of biological chemistry 20071214 |
| PPARalpha-dependent induction of the energy homeostasis-regulating nuclear receptor NR1i3 (CAR) in rat hepatocytes: potential role in starvation adaptation. | FEBS letters 20071211 |
| Epigenetic effects of the continuous exposure to peroxisome proliferator WY-14,643 in mouse liver are dependent upon peroxisome proliferator activated receptor alpha. | Mutation research 20071201 |
| Inactivation of peroxisome proliferator-activated receptor isoforms alpha, beta/delta, and gamma mediate distinct facets of hypertrophic transformation of adult cardiac myocytes. | Pflugers Archiv : European journal of physiology 20071201 |
| PPARalpha and PP2A are involved in the proapoptotic effect of conjugated linoleic acid on human hepatoma cell line SK-HEP-1. | International journal of cancer 20071201 |
| PPARalpha agonists inhibit nitric oxide production by enhancing iNOS degradation in LPS-treated macrophages. | British journal of pharmacology 20071201 |
| Hepatic PGC-1beta overexpression induces combined hyperlipidemia and modulates the response to PPARalpha activation. | Arteriosclerosis, thrombosis, and vascular biology 20071201 |
| Peroxisome proliferator-activated receptor-alpha is required for the neurotrophic effect of oleic acid in neurons. | Journal of neurochemistry 20071101 |
| Norepinephrine and rosiglitazone synergistically induce Elovl3 expression in brown adipocytes. | American journal of physiology. Endocrinology and metabolism 20071101 |
| WY14,643, a PPARalpha ligand, attenuates expression of anti-glomerular basement membrane disease. | Clinical and experimental immunology 20071101 |
| Delta5 desaturase mRNA levels are increased by simvastatin via SREBP-1 at early stages, not via PPARalpha, in THP-1 cells. | European journal of pharmacology 20071001 |
| Macrophage expression of peroxisome proliferator-activated receptor-alpha reduces atherosclerosis in low-density lipoprotein receptor-deficient mice. | Circulation 20070918 |
| Peroxisome proliferator-activated receptor alpha is involved in cardiomyocyte differentiation of murine embryonic stem cells in vitro. | Cell biology international 20070901 |
| Cytotoxicity of peroxisome proliferator-activated receptor alpha and gamma agonists in renal proximal tubular cell lines. | Toxicology in vitro : an international journal published in association with BIBRA 20070901 |
| The putative tumor suppressor Tsc-22 is downregulated early in chemically induced hepatocarcinogenesis and may be a suppressor of Gadd45b. | Toxicological sciences : an official journal of the Society of Toxicology 20070901 |
| Metabolomic and genetic analysis of biomarkers for peroxisome proliferator-activated receptor alpha expression and activation. | Molecular endocrinology (Baltimore, Md.) 20070901 |
| Different mechanisms of modulation of gap junction communication by non-genotoxic carcinogens in rat liver in vivo. | Toxicology 20070816 |
| Uncoupling protein-2 up-regulation and enhanced cyanide toxicity are mediated by PPARalpha activation and oxidative stress. | Toxicology and applied pharmacology 20070815 |
| WY-14,643 induced cell proliferation and oxidative stress in mouse liver are independent of NADPH oxidase. | Toxicological sciences : an official journal of the Society of Toxicology 20070801 |
| The acyl-CoA thioesterase I is regulated by PPARalpha and HNF4alpha via a distal response element in the promoter. | Journal of lipid research 20070801 |
| A role of liver fatty acid-binding protein in cisplatin-induced acute renal failure. | Kidney international 20070801 |
| Phenylpropanoic acid derivatives bearing a benzothiazole ring as PPARdelta-selective agonists. | Bioorganic & medicinal chemistry letters 20070801 |
| Activation of PPARdelta inhibits cardiac fibroblast proliferation and the transdifferentiation into myofibroblasts. | Cardiovascular research 20070801 |
| Genome-wide analysis of PPARalpha activation in murine small intestine. | Physiological genomics 20070718 |
| Cytochrome P450 eicosanoids are activators of peroxisome proliferator-activated receptor alpha. | Drug metabolism and disposition: the biological fate of chemicals 20070701 |
| Quinoline-based derivatives of pirinixic acid as dual PPAR alpha/gamma agonists. | Archiv der Pharmazie 20070701 |
| Peroxisomal proliferator-activated receptor-alpha-dependent inhibition of endothelial cell proliferation and tumorigenesis. | The Journal of biological chemistry 20070615 |
| Indomethacin induces apoptosis in 786-O renal cell carcinoma cells by activating mitogen-activated protein kinases and AKT. | European journal of pharmacology 20070601 |
| PPARalpha agonists suppress osteopontin expression in macrophages and decrease plasma levels in patients with type 2 diabetes. | Diabetes 20070601 |
| Expression of heme oxygenase-1 in human vascular cells is regulated by peroxisome proliferator-activated receptors. | Arteriosclerosis, thrombosis, and vascular biology 20070601 |
| The peroxisome proliferator WY-14,643 promotes hepatocarcinogenesis caused by endogenously generated oxidative DNA base modifications in repair-deficient Csbm/m/Ogg1-/- mice. | Cancer research 20070601 |
| The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver. | Journal of hepatology 20070501 |
| Glycogen synthase 2 is a novel target gene of peroxisome proliferator-activated receptors. | Cellular and molecular life sciences : CMLS 20070501 |
| Beyond lipids, pharmacological PPARalpha activation has important effects on amino acid metabolism as studied in the rat. | American journal of physiology. Endocrinology and metabolism 20070401 |
| Synthesis and evaluation of N-acetyl-L-tyrosine based compounds as PPARalpha selective activators. | European journal of medicinal chemistry 20070401 |
| Peroxisome proliferator-activated receptor-alpha activation inhibits Langerhans cell function. | Journal of immunology (Baltimore, Md. : 1950) 20070401 |
| PPARdelta, but not PPARalpha, activates PGC-1alpha gene transcription in muscle. | Biochemical and biophysical research communications 20070323 |
| Immunoselection and characterization of a human genomic PPAR binding fragment located within POTE genes. | Biochimie 20070301 |
| Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor alpha activation. | Drug metabolism and disposition: the biological fate of chemicals 20070301 |
| Tetradecylselenoacetic acid, a PPAR ligand with antioxidant, antiinflammatory, and hypolipidemic properties. | Arteriosclerosis, thrombosis, and vascular biology 20070301 |
| PPARalpha agonist induces the accumulation of ceramide in the heart of rats fed high-fat diet. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20070301 |
| Activation of PPARalpha lowers synthesis and concentration of cholesterol by reduction of nuclear SREBP-2. | Biochemical pharmacology 20070215 |
| Peroxisome proliferator-activated receptor alpha-independent effects of peroxisome proliferators on cysteinyl leukotriene production in mast cells. | European journal of pharmacology 20070205 |
| The dominant negative thyroid hormone receptor beta-mutant {Delta}337T alters PPAR{alpha} signaling in heart. | American journal of physiology. Endocrinology and metabolism 20070201 |
| Sustained formation of alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone radical adducts in mouse liver by peroxisome proliferators is dependent upon peroxisome proliferator-activated receptor-alpha, but not NADPH oxidase. | Free radical biology & medicine 20070201 |
| Activation of peroxisome proliferator-activated receptor gamma contributes to the survival of T lymphoma cells by affecting cellular metabolism. | The American journal of pathology 20070201 |
| Novel sulfamide analogs of oleoylethanolamide showing in vivo satiety inducing actions and PPARalpha activation. | Journal of medicinal chemistry 20070125 |
| Metabolism of phytol to phytanic acid in the mouse, and the role of PPARalpha in its regulation. | Journal of lipid research 20070101 |
| Gypenoside XLIX, a naturally occurring gynosaponin, PPAR-alpha dependently inhibits LPS-induced tissue factor expression and activity in human THP-1 monocytic cells. | Toxicology and applied pharmacology 20070101 |
| Cardiovascular actions of the peroxisome proliferator-activated receptor-alpha (PPARalpha) agonist Wy14,643. | Cardiovascular drug reviews 20070101 |
| In vitro screening of 200 pesticides for agonistic activity via mouse peroxisome proliferator-activated receptor (PPAR)alpha and PPARgamma and quantitative analysis of in vivo induction pathway. | Toxicology and applied pharmacology 20061215 |
| Wy-14,643 and fenofibrate inhibit mitochondrial respiration in isolated rat cardiac mitochondria. | Mitochondrion 20061201 |
| Peroxisome proliferator-activated receptor-alpha and glucocorticoids interactively regulate insulin secretion during pregnancy. | Diabetes 20061201 |
| Profiling of gene expression in rat liver and rat primary cultured hepatocytes treated with peroxisome proliferators. | The Journal of toxicological sciences 20061201 |
| Induction of intestinal peptide transporter 1 expression during fasting is mediated via peroxisome proliferator-activated receptor alpha. | American journal of physiology. Gastrointestinal and liver physiology 20061101 |
| Human UDP-glucuronosyltransferase (UGT)1A3 enzyme conjugates chenodeoxycholic acid in the liver. | Hepatology (Baltimore, Md.) 20061101 |
| Regulation of mouse hepatic alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase, a key enzyme in the tryptophan-nicotinamide adenine dinucleotide pathway, by hepatocyte nuclear factor 4alpha and peroxisome proliferator-activated receptor alpha. | Molecular pharmacology 20061001 |
| Peroxisome proliferator-activated receptor alpha activation during pregnancy severely impairs mammary lobuloalveolar development in mice. | Endocrinology 20061001 |
| WY 14,643 inhibits human aldose reductase activity. | Journal of enzyme inhibition and medicinal chemistry 20061001 |
| Peroxisome proliferator-activated receptor-alpha-null mice have increased white adipose tissue glucose utilization, GLUT4, and fat mass: Role in liver and brain. | Endocrinology 20060901 |
| PPARalpha-mediated upregulation of uncoupling protein-2 switches cyanide-induced apoptosis to necrosis in primary cortical cells. | Toxicological sciences : an official journal of the Society of Toxicology 20060901 |
| Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity. | Journal of lipid research 20060901 |
| Transcriptomic and phylogenetic analysis of Kpna genes: a family of nuclear import factors modulated in xenobiotic-mediated liver growth. | Pharmacogenetics and genomics 20060901 |
| Cardiomyocytic apoptosis following global cardiac ischemia and reperfusion can be attenuated by peroxisome proliferator-activated receptor alpha but not gamma activators. | Shock (Augusta, Ga.) 20060901 |
| Key issues in the role of peroxisome proliferator-activated receptor agonism and cell signaling in trichloroethylene toxicity. | Environmental health perspectives 20060901 |
| Oxidative stress and inflammatory response evoked by transient cerebral ischemia/reperfusion: effects of the PPAR-alpha agonist WY14643. | Free radical biology & medicine 20060815 |
| Activation of peroxisome proliferator-activated receptor alpha enhances apoptosis in the mouse liver. | Toxicological sciences : an official journal of the Society of Toxicology 20060801 |
| Agonists of the peroxisome proliferator-activated receptor alpha induce a fiber-type-selective transcriptional response in rat skeletal muscle. | Toxicological sciences : an official journal of the Society of Toxicology 20060801 |
| [Influence and mechanism of peroxisome proliferation activated receptor-alpha expression induced by WY14643 in rat lung with acute lung injury]. | Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20060801 |
| PPARalpha and PPARgamma regulation of liver and adipose proteins in obese and dyslipidemic rodents. | Journal of proteome research 20060801 |
| Regulation of rat hepatic L-pyruvate kinase promoter composition and activity by glucose, n-3 polyunsaturated fatty acids, and peroxisome proliferator-activated receptor-alpha agonist. | The Journal of biological chemistry 20060707 |
| The PPARalpha/gamma dual agonist chiglitazar improves insulin resistance and dyslipidemia in MSG obese rats. | British journal of pharmacology 20060701 |
| Mono(2-ethylhexyl)phthalate and mono-n-butyl phthalate activation of peroxisome proliferator activated-receptors alpha and gamma in breast. | Toxicology letters 20060601 |
| Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel. | The Journal of clinical investigation 20060601 |
| Differential effects of contraction and PPAR agonists on the expression of fatty acid transporters in rat skeletal muscle. | The Journal of physiology 20060515 |
| Differential susceptibility of mice humanized for peroxisome proliferator-activated receptor alpha to Wy-14,643-induced liver tumorigenesis. | Carcinogenesis 20060501 |
| Protection against myocardial ischaemia/reperfusion injury by PPAR-alpha activation is related to production of nitric oxide and endothelin-1. | Basic research in cardiology 20060501 |
| PPARalpha activators and fasting induce the expression of adipose differentiation-related protein in liver. | Journal of lipid research 20060501 |
| Synthesis and anti-diabetic activity of (RS)-2-ethoxy-3-{4-[2-(4-trifluoro-methanesulfonyloxy-phenyl)-ethoxy]-phenyl}-propionic acid. | Acta pharmacologica Sinica 20060501 |
| Inhibition of hepatocarcinogenesis by the deletion of the p50 subunit of NF-kappaB in mice administered the peroxisome proliferator Wy-14,643. | Toxicological sciences : an official journal of the Society of Toxicology 20060401 |
| Fenofibrate activates AMPK and increases eNOS phosphorylation in HUVEC. | Biochemical and biophysical research communications 20060324 |
| Peroxisome proliferator-activated receptor alpha mediates the effects of high-fat diet on hepatic gene expression. | Endocrinology 20060301 |
| Effects of fatty acids on skeletal muscle cell differentiation in vitro. | The British journal of nutrition 20060301 |
| Niacin induces PPARgamma expression and transcriptional activation in macrophages via HM74 and HM74a-mediated induction of prostaglandin synthesis pathways. | Biochemical pharmacology 20060227 |
| PPARalpha activation increases triglyceride mass and adipose differentiation-related protein in hepatocytes. | Journal of lipid research 20060201 |
| Ginsenoside Rf, a component of ginseng, regulates lipoprotein metabolism through peroxisome proliferator-activated receptor alpha. | Biochemical and biophysical research communications 20060106 |
| Toxic effects of fumonisin in mouse liver are independent of the peroxisome proliferator-activated receptor alpha. | Toxicological sciences : an official journal of the Society of Toxicology 20060101 |
| Transcriptional regulation of the PXR gene: identification and characterization of a functional peroxisome proliferator-activated receptor alpha binding site within the proximal promoter of PXR. | Drug metabolism and disposition: the biological fate of chemicals 20060101 |
| Gene expression profiles in rat liver slices exposed to hepatocarcinogenic enzyme inducers, peroxisome proliferators, and 17alpha-ethinylestradiol. | International journal of toxicology 20060101 |
| Differential gene expression in mouse primary hepatocytes exposed to the peroxisome proliferator-activated receptor alpha agonists. | BMC bioinformatics 20060101 |
| Hepatocellular proliferation in response to agonists of peroxisome proliferator-activated receptor alpha: a role for Kupffer cells? | Journal of carcinogenesis 20060101 |
| PPARalpha activation upregulates nephrin expression in human embryonic kidney epithelial cells and podocytes by a dual mechanism. | Biochemical and biophysical research communications 20051230 |
| PPARalpha activation potentiates AhR-induced CYP1A1 expression. | Toxicology 20051215 |
| Peroxisomal proliferation protects from beta-amyloid neurodegeneration. | The Journal of biological chemistry 20051209 |
| Peroxisome proliferator-activated receptor (PPAR)alpha activation increases adiponectin receptors and reduces obesity-related inflammation in adipose tissue: comparison of activation of PPARalpha, PPARgamma, and their combination. | Diabetes 20051201 |
| Plasma free fatty acids and peroxisome proliferator-activated receptor alpha in the control of myocardial uncoupling protein levels. | Diabetes 20051201 |
| ROLE OF ENDOGENOUS AND EXOGENOUS LIGANDS FOR THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR alpha IN THE DEVELOPMENT OF BLEOMYCIN-INDUCED LUNG INJURY. | Shock (Augusta, Ga.) 20051201 |
| The identification of a succinyl-CoA thioesterase suggests a novel pathway for succinate production in peroxisomes. | The Journal of biological chemistry 20051118 |
| Statins and PPARalpha agonists induce myotoxicity in differentiated rat skeletal muscle cultures but do not exhibit synergy with co-treatment. | Toxicology and applied pharmacology 20051101 |
| Synthesis of new carbo- and heterocyclic analogues of 8-HETE and evaluation of their activity towards the PPARs. | Bioorganic & medicinal chemistry letters 20051015 |
| Use of proteomic methods to identify serum biomarkers associated with rat liver toxicity or hypertrophy. | Clinical chemistry 20051001 |
| Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity. | American journal of physiology. Regulatory, integrative and comparative physiology 20050901 |
| A teleost in vitro reporter gene assay to screen for agonists of the peroxisome proliferator-activated receptors. | Environmental toxicology and chemistry 20050901 |
| Synthesis, biological evaluation, and molecular modeling investigation of new chiral fibrates with PPARalpha and PPARgamma agonist activity. | Journal of medicinal chemistry 20050825 |
| Comparison of the expression profiles induced by genotoxic and nongenotoxic carcinogens in rat liver. | Mutation research 20050804 |
| Regulation of peroxisome proliferator-activated receptor alpha by protein kinase C. | Biochemistry 20050802 |
| Anti-inflammatory effect of fibrate protects from cisplatin-induced ARF. | American journal of physiology. Renal physiology 20050801 |
| Peroxisome proliferator-activated receptor alpha (PPARalpha) potentiates, whereas PPARgamma attenuates, glucose-stimulated insulin secretion in pancreatic beta-cells. | Endocrinology 20050801 |
| Agonists for the peroxisome proliferator-activated receptor-alpha and the retinoid X receptor inhibit inflammatory responses of microglia. | Journal of neuroscience research 20050801 |
| A role for PPARalpha in the control of SREBP activity and lipid synthesis in the liver. | The Biochemical journal 20050715 |
| Evaluation of cytochrome P450 4 family as mediator of phospholipase D activation in aortic vascular smooth muscle cells. | Life sciences 20050715 |
| Activation of peroxisome proliferator-activated receptor alpha by substituted urea-derived soluble epoxide hydrolase inhibitors. | The Journal of pharmacology and experimental therapeutics 20050701 |
| Adiponectin receptor gene expression in human skeletal muscle cells is not regulated by fibrates and thiazolidinediones. | International journal of obesity (2005) 20050701 |
| Peroxisome proliferator-activated receptor alpha and its response element are required but not sufficient for transcriptional activation of the mouse heart-type fatty acid binding protein gene. | The international journal of biochemistry & cell biology 20050701 |
| A new retinoid-like compound that activates peroxisome proliferator-activated receptors and lowers blood glucose in diabetic mice. | Biological & pharmaceutical bulletin 20050701 |
| Oleoylethanolamide, an endogenous PPAR-alpha agonist, lowers body weight and hyperlipidemia in obese rats. | Neuropharmacology 20050601 |
| Inhibitors of the arachidonic acid pathway and peroxisome proliferator-activated receptor ligands have superadditive effects on lung cancer growth inhibition. | Cancer research 20050515 |
| Peroxisome proliferator-activated receptor alpha physically interacts with CCAAT/enhancer binding protein (C/EBPbeta) to inhibit C/EBPbeta-responsive alpha1-acid glycoprotein gene expression. | Molecular endocrinology (Baltimore, Md.) 20050501 |
| Conditional regulation of the human CYP4X1 and CYP4Z1 genes. | Archives of biochemistry and biophysics 20050415 |
| Regulation of human hepatic hydroxysteroid sulfotransferase gene expression by the peroxisome proliferator-activated receptor alpha transcription factor. | Molecular pharmacology 20050401 |
| Tissue-specific, nutritional, and developmental regulation of rat fatty acid elongases. | Journal of lipid research 20050401 |
| Future strategies in the treatment of acute renal failure: growth factors, stem cells, and other novel therapies. | Current opinion in pediatrics 20050401 |
| Unique patterns of gene expression changes in liver after treatment of mice for 2 weeks with different known carcinogens and non-carcinogens. | Carcinogenesis 20050301 |
| Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids. | Archives of biochemistry and biophysics 20050201 |
| Differential regulation of chemokine expression by peroxisome proliferator-activated receptor gamma agonists: interactions with glucocorticoids and beta2-agonists. | The Journal of biological chemistry 20050128 |
| Activation of peroxisome proliferator-activated receptor alpha increases the expression and activity of microsomal triglyceride transfer protein in the liver. | The Journal of biological chemistry 20050114 |
| Role of peroxisome proliferator-activated receptor-alpha (PPARalpha) in bezafibrate-induced hepatocarcinogenesis and cholestasis. | Carcinogenesis 20050101 |
| The peroxisome proliferator-activated receptor alpha activator, Wy14,643, is anti-inflammatory in vivo. | Inflammopharmacology 20050101 |
| Effects of xenobiotics and peroxisome proliferator-activated receptor-alpha on the human UDPglucose dehydrogenase gene expression. | Journal of biochemical and molecular toxicology 20050101 |
| The transcriptional response to a peroxisome proliferator-activated receptor alpha agonist includes increased expression of proteome maintenance genes. | The Journal of biological chemistry 20041210 |
| Peroxisome proliferator-activated receptor alpha induces NADPH oxidase activity in macrophages, leading to the generation of LDL with PPAR-alpha activation properties. | Circulation research 20041210 |
| Overlapping transcriptional programs regulated by the nuclear receptors peroxisome proliferator-activated receptor alpha, retinoid X receptor, and liver X receptor in mouse liver. | Molecular pharmacology 20041201 |
| Peroxisome proliferator-activated receptor alpha regulates B lymphocyte development via an indirect pathway in mice. | Biochemical pharmacology 20041201 |
| PPARalpha ligands activate antioxidant enzymes and suppress hepatic fibrosis in rats. | Biochemical and biophysical research communications 20041112 |
| Evidence for mitochondrial thioesterase 1 as a peroxisome proliferator-activated receptor-alpha-regulated gene in cardiac and skeletal muscle. | American journal of physiology. Endocrinology and metabolism 20041101 |
| alpha(2)-Macroglobulin: a novel cytochemical marker characterizing preneoplastic and neoplastic rat liver lesions negative for hitherto established cytochemical markers. | The American journal of pathology 20041101 |
| Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites. | Gastroenterology 20041101 |
| Mimetics of caloric restriction include agonists of lipid-activated nuclear receptors. | The Journal of biological chemistry 20041029 |
| Statin induction of liver fatty acid-binding protein (L-FABP) gene expression is peroxisome proliferator-activated receptor-alpha-dependent. | The Journal of biological chemistry 20041029 |
| PPARalpha activators down-regulate CYP2C7, a retinoic acid and testosterone hydroxylase. | Toxicology 20041015 |
| Role of the peroxisome proliferator-activated receptor alpha (PPARalpha) in responses to trichloroethylene and metabolites, trichloroacetate and dichloroacetate in mouse liver. | Toxicology 20041015 |
| Integrated genomic and proteomic analyses of gene expression in Mammalian cells. | Molecular & cellular proteomics : MCP 20041001 |
| WY 14643, a potent exogenous PPAR-alpha ligand, reduces intestinal injury associated with splanchnic artery occlusion shock. | Shock (Augusta, Ga.) 20041001 |
| Enhancement of insulin signaling through inhibition of tissue lipid accumulation by activation of peroxisome proliferator-activated receptor (PPAR) alpha in obese mice. | Medical science monitor : international medical journal of experimental and clinical research 20041001 |
| 17beta-hydroxysteroid dehydrogenase type 11 is a major peroxisome proliferator-activated receptor alpha-regulated gene in mouse intestine. | European journal of biochemistry 20041001 |
| Peroxisome proliferator-activated receptor and farnesoid X receptor ligands differentially regulate sebaceous differentiation in human sebaceous gland organ cultures in vitro. | The British journal of dermatology 20041001 |
| Beneficial and deleterious effects of rosiglitazone on hypertension development in spontaneously hypertensive rats. | American journal of hypertension 20040901 |
| PPARalpha agonists stimulate progastrin production in human colorectal carcinoma cells. | Regulatory peptides 20040815 |
| Molecular mechanisms of alcoholic fatty liver: role of peroxisome proliferator-activated receptor alpha. | Alcohol (Fayetteville, N.Y.) 20040801 |
| Effect of the peroxisome proliferator-activated receptor beta activator GW0742 in rat cultured cerebellar granule neurons. | Journal of neuroscience research 20040715 |
| Design, synthesis, and evaluation of a new class of noncyclic 1,3-dicarbonyl compounds as PPARalpha selective activators. | Bioorganic & medicinal chemistry letters 20040705 |
| Effects of peroxisome proliferator-activated receptor alpha activation on pathways contributing to cholesterol homeostasis in rat hepatocytes. | Biochimica et biophysica acta 20040705 |
| Oleoylethanolamide stimulates lipolysis by activating the nuclear receptor peroxisome proliferator-activated receptor alpha (PPAR-alpha). | The Journal of biological chemistry 20040702 |
| Dissociation of oxidant production by peroxisome proliferator-activated receptor ligands from cell death in human cell lines. | Free radical biology & medicine 20040701 |
| Protein profiling of mouse livers with peroxisome proliferator-activated receptor alpha activation. | Molecular and cellular biology 20040701 |
| WY-14643 and 9- cis-retinoic acid induce IRS-2/PI 3-kinase signalling pathway and increase glucose transport in human skeletal muscle cells: differential effect in myotubes from healthy subjects and Type 2 diabetic patients. | Diabetologia 20040701 |
| Different ways to regulate the PPARalpha stability. | Biochemical and biophysical research communications 20040625 |
| Transcription coactivator PBP, the peroxisome proliferator-activated receptor (PPAR)-binding protein, is required for PPARalpha-regulated gene expression in liver. | The Journal of biological chemistry 20040604 |
| Coadministration of a liver X receptor agonist and a peroxisome proliferator activator receptor-alpha agonist in Mice: effects of nuclear receptor interplay on high-density lipoprotein and triglyceride metabolism in vivo. | The Journal of pharmacology and experimental therapeutics 20040601 |
| Differential regulation of cytosolic and peroxisomal bile acid amidation by PPAR alpha activation favors the formation of unconjugated bile acids. | Journal of lipid research 20040601 |
| Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor alpha. | Cancer research 20040601 |
| The human semaphorin 6B gene is down regulated by PPARs. | Genomics 20040601 |
| Molecular cloning and characterization of two mouse peroxisome proliferator-activated receptor alpha (PPARalpha)-regulated peroxisomal acyl-CoA thioesterases. | The Journal of biological chemistry 20040521 |
| Activation of peroxisome proliferator-activated receptor gamma inhibits interleukin-1beta-induced membrane-associated prostaglandin E2 synthase-1 expression in human synovial fibroblasts by interfering with Egr-1. | The Journal of biological chemistry 20040521 |
| Modulation of PPARalpha expression and inflammatory interleukin-6 production by chronic glucose increases monocyte/endothelial adhesion. | Arteriosclerosis, thrombosis, and vascular biology 20040501 |
| Administration of the potent PPARalpha agonist, Wy-14,643, reverses nutritional fibrosis and steatohepatitis in mice. | Hepatology (Baltimore, Md.) 20040501 |
| Cardiovascular drugs inhibit MMP-9 activity from human THP-1 macrophages. | DNA and cell biology 20040501 |
| Peroxisome proliferator-activated receptor-alpha regulates postischemic liver injury. | American journal of physiology. Gastrointestinal and liver physiology 20040401 |
| Peroxisome proliferator-activated receptor alpha agonists increase nitric oxide synthase expression in vascular endothelial cells. | Arteriosclerosis, thrombosis, and vascular biology 20040401 |
| Characterization of the species-specificity of peroxisome proliferators in rat and human hepatocytes. | Toxicological sciences : an official journal of the Society of Toxicology 20040401 |
| Peroxisomal-proliferator-activated receptor alpha activates transcription of the rat hepatic malonyl-CoA decarboxylase gene: a key regulation of malonyl-CoA level. | The Biochemical journal 20040315 |
| PPAR alpha ligand protects during cisplatin-induced acute renal failure by preventing inhibition of renal FAO and PDC activity. | American journal of physiology. Renal physiology 20040301 |
| Reduction of palmitate-induced cardiac apoptosis by fenofibrate. | Molecular and cellular biochemistry 20040301 |
| PPARalpha activators inhibit vascular endothelial growth factor receptor-2 expression by repressing Sp1-dependent DNA binding and transactivation. | Circulation research 20040220 |
| Catalase transgenic mice: characterization and sensitivity to oxidative stress. | Archives of biochemistry and biophysics 20040215 |
| Expression of base excision DNA repair genes is a sensitive biomarker for in vivo detection of chemical-induced chronic oxidative stress: identification of the molecular source of radicals responsible for DNA damage by peroxisome proliferators. | Cancer research 20040201 |
| Transcriptional inactivation of STAT3 by PPARgamma suppresses IL-6-responsive multiple myeloma cells. | Immunity 20040201 |
| 15-Deoxy-delta(12,14)-prostaglandin J2 inhibits the IL-1beta-induced expression of granulocyte-macrophage colony-stimulating factor in BEAS-2B bronchial epithelial cells. | The Tohoku journal of experimental medicine 20040201 |
| Hepatocarcinogenesis by peroxisome proliferators. | The Journal of toxicological sciences 20040201 |
| Expression of adiponectin receptors in human macrophages and regulation by agonists of the nuclear receptors PPARalpha, PPARgamma, and LXR. | Biochemical and biophysical research communications 20040130 |
| Peroxisome proliferator-activated receptor delta activates fatty acid oxidation in cultured neonatal and adult cardiomyocytes. | Biochemical and biophysical research communications 20040109 |
| Gene expression changes in rat liver following exposure to liver growth agents: role of Kupffer cells in xenobiotic-mediated liver growth. | Biochemical pharmacology 20040101 |
| Relationship between PPARalpha activation and NO on proximal tubular Na+ transport in the rat. | BMC pharmacology 20040101 |
| Peroxisome proliferator-activated receptor agonists inhibit interleukin-1beta-mediated nitric oxide production in cultured lacrimal gland acinar cells. | Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20031201 |
| Inhibition of cholesterol absorption associated with a PPAR alpha-dependent increase in ABC binding cassette transporter A1 in mice. | Journal of lipid research 20031101 |
| Induction of plasminogen activator inhibitor I by the PPARalpha ligand, Wy-14,643, is dependent on ERK1/2 signaling pathway. | Thrombosis and haemostasis 20031001 |
| WY-14,643-mediated promotion of hepatocarcinogenesis in connexin32-wild-type and connexin32-null mice. | Carcinogenesis 20030901 |
| Assessment of hepatocytes and liver slices as in vitro test systems to predict in vivo gene expression. | Toxicological sciences : an official journal of the Society of Toxicology 20030901 |
| Peroxisome proliferator activated receptor (PPAR)alpha agonists inhibit hypertrophy of neonatal rat cardiac myocytes. | Endocrinology 20030901 |
| Peroxisome proliferator-activated receptor alpha induces hepatic expression of the human bile acid glucuronidating UDP-glucuronosyltransferase 2B4 enzyme. | The Journal of biological chemistry 20030829 |
| Peroxisome proliferator-activated receptor alpha (PPARalpha) agonist treatment reverses PPARalpha dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice. | The Journal of biological chemistry 20030725 |
| Control of cardiac pyruvate dehydrogenase activity in peroxisome proliferator-activated receptor-alpha transgenic mice. | American journal of physiology. Heart and circulatory physiology 20030701 |
| Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of LXR signaling. | Molecular endocrinology (Baltimore, Md.) 20030701 |
| Peroxisome proliferator-activated receptor-alpha agonist treatment in a transgenic model of type 2 diabetes reverses the lipotoxic state and improves glucose homeostasis. | Diabetes 20030701 |
| Central role of PPARalpha-dependent hepatic lipid turnover in dietary steatohepatitis in mice. | Hepatology (Baltimore, Md.) 20030701 |
| Bezafibrate is a dual ligand for PPARalpha and PPARbeta: studies using null mice. | Biochimica et biophysica acta 20030610 |
| Identification of hepatic transcriptional changes in insulin-resistant rats treated with peroxisome proliferator activated receptor-alpha agonists. | Journal of molecular endocrinology 20030601 |
| Apolipoprotein A5, a crucial determinant of plasma triglyceride levels, is highly responsive to peroxisome proliferator-activated receptor alpha activators. | The Journal of biological chemistry 20030516 |
| Increased expression of the lipocalin 24p3 as an apoptotic mechanism for MK886. | The Biochemical journal 20030515 |
| Activation-induced PPARgamma expression sensitizes primary human T cells toward apoptosis. | Journal of leukocyte biology 20030501 |
| Comprehensive analysis of gene expression in rat and human hepatoma cells exposed to the peroxisome proliferator WY14,643. | Toxicology and applied pharmacology 20030501 |
| Acute (24 h) activation of peroxisome proliferator-activated receptor-alpha (PPARalpha) reverses high-fat feeding-induced insulin hypersecretion in vivo and in perifused pancreatic islets. | The Journal of endocrinology 20030501 |
| Dysregulation of DNA repair pathways in a transforming growth factor alpha/c-myc transgenic mouse model of accelerated hepatocarcinogenesis. | Laboratory investigation; a journal of technical methods and pathology 20030501 |
| Hepatic protein expression of lean mice and obese diabetic mice treated with peroxisome proliferator-activated receptor activators. | Proteomics 20030401 |
| Protein expression changes in the Sprague Dawley rat liver proteome following administration of peroxisome proliferator activated receptor alpha and gamma ligands. | Proteomics 20030401 |
| Peroxisome proliferator-activated receptor alpha is involved in the regulation of lipid metabolism by ginseng. | British journal of pharmacology 20030401 |
| Changes in global gene and protein expression during early mouse liver carcinogenesis induced by non-genotoxic model carcinogens oxazepam and Wyeth-14,643. | Carcinogenesis 20030401 |
| Activation of peroxisome proliferator-activated receptors alpha and gamma1 inhibits human smooth muscle cell proliferation. | Molecular and cellular biochemistry 20030401 |
| 15-Deoxy-Delta(12,14)-prostaglandin J2 inhibits the expression of proinflammatory genes in human blood monocytes via a PPAR-gamma-independent mechanism. | Biochemical and biophysical research communications 20030307 |
| PPARalpha /gamma ragaglitazar eliminates fatty liver and enhances insulin action in fat-fed rats in the absence of hepatomegaly. | American journal of physiology. Endocrinology and metabolism 20030301 |
| Activation of peroxisome proliferator-activated receptors in human airway smooth muscle cells has a superior anti-inflammatory profile to corticosteroids: relevance for chronic obstructive pulmonary disease therapy. | Journal of immunology (Baltimore, Md. : 1950) 20030301 |
| PPAR agonists protect mesangial cells from interleukin 1beta-induced intracellular lipid accumulation by activating the ABCA1 cholesterol efflux pathway. | Journal of the American Society of Nephrology : JASN 20030301 |
| Age-dependent effects of nongenotoxic hepatocarcinogens on liver apoptosis in vivo. | Mechanisms of ageing and development 20030301 |
| Peroxisome proliferator-activated receptor alpha reduces cholesterol esterification in macrophages. | Circulation research 20030207 |
| Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice. | The Biochemical journal 20030201 |
| Investigation of potential mechanisms regulating protein expression of hepatic pyruvate dehydrogenase kinase isoforms 2 and 4 by fatty acids and thyroid hormone. | The Biochemical journal 20030201 |
| Differential and bi-directional regulation between TR2/TR4 orphan nuclear receptors and a specific ligand mediated-peroxisome proliferator-activated receptor alpha in human HaCaT keratinocytes. | Journal of dermatological science 20030201 |
| Rosiglitazone and retinoic acid induce uncoupling protein-1 (UCP-1) in a p38 mitogen-activated protein kinase-dependent manner in fetal primary brown adipocytes. | The Journal of biological chemistry 20030103 |
| Differential regulation of human CYP4A genes by peroxisome proliferators and dexamethasone. | Archives of biochemistry and biophysics 20030101 |
| Peroxisome proliferator-activated receptor-alpha activation during pregnancy attenuates glucose-stimulated insulin hypersecretion in vivo by increasing insulin sensitivity, without impairing pregnancy-induced increases in beta-cell glucose sensing and responsiveness. | Endocrinology 20030101 |
| Delayed induction of delta-6 and delta-5 desaturases by a peroxisome proliferator. | Biochemical and biophysical research communications 20021220 |
| WY14,643, a PPAR alpha ligand, has profound effects on immune responses in vivo. | Journal of immunology (Baltimore, Md. : 1950) 20021215 |
| Non-genotoxic carcinogens: early effects on gap junctions, cell proliferation and apoptosis in the rat. | Toxicology 20021202 |
| Peroxisome proliferator-activated receptor activators inhibit oxidized low-density lipoprotein-induced endothelin-1 secretion in endothelial cells. | Journal of cardiovascular pharmacology 20021201 |
| Agonists of peroxisome-proliferator activated receptor-alpha (clofibrate and WY14643) reduce renal ischemia/reperfusion injury in the rat. | Medical science monitor : international medical journal of experimental and clinical research 20021201 |
| Hepatic expression of polymerase beta, Ref-1, PCNA, and Bax in WY 14,643-exposed rats and hamsters. | Experimental and molecular pathology 20021201 |
| PPAR-alpha ligands inhibit H2O2-mediated activation of transforming growth factor-beta1 in human mesangial cells. | Antioxidants & redox signaling 20021201 |
| PPARalpha inhibits TGF-beta-induced beta5 integrin transcription in vascular smooth muscle cells by interacting with Smad4. | Circulation research 20021129 |
| Clofibric acid stimulates branched-chain amino acid catabolism by three mechanisms. | Archives of biochemistry and biophysics 20021115 |
| AZ 242, a novel PPARalpha/gamma agonist with beneficial effects on insulin resistance and carbohydrate and lipid metabolism in ob/ob mice and obese Zucker rats. | Journal of lipid research 20021101 |
| A metabolic switching hypothesis for the first step in the hypolipidemic effects of fibrates. | Biological & pharmaceutical bulletin 20021101 |
| PPAR alpha stimulates the rat gastrin-producing cell. | Molecular and cellular endocrinology 20020930 |
| Peroxisome proliferator-activated receptor ligands negatively regulate the expression of the high-affinity IgE receptor Fc epsilon RI in human basophilic KU812 cells. | Biochemical and biophysical research communications 20020920 |
| Inhibition of cytokine-induced matrix metalloproteinase 9 expression by peroxisome proliferator-activated receptor alpha agonists is indirect and due to a NO-mediated reduction of mRNA stability. | The Journal of biological chemistry 20020906 |
| PPAR agonists amplify iNOS expression while inhibiting NF-kappaB: implications for mesangial cell activation by cytokines. | Journal of the American Society of Nephrology : JASN 20020901 |
| Use of a quantitative real-time reverse transcription-polymerase chain reaction method to study the induction of CYP1A, CYP2B and CYP4A forms in precision-cut rat liver slices. | Xenobiotica; the fate of foreign compounds in biological systems 20020901 |
| Effects of the rat hepatic peroxisome proliferator, Wyeth 14,643, on the lactating goat. | Drug and chemical toxicology 20020801 |
| Peroxisome proliferator-activated receptor alpha in the human breast cancer cell lines MCF-7 and MDA-MB-231. | Molecular carcinogenesis 20020801 |
| Interactions of fluorochemicals with rat liver fatty acid-binding protein. | Toxicology 20020715 |
| WY14,643, a peroxisome proliferator-activated receptor alpha (PPARalpha ) agonist, improves hepatic and muscle steatosis and reverses insulin resistance in lipoatrophic A-ZIP/F-1 mice. | The Journal of biological chemistry 20020705 |
| Ligands of the peroxisome proliferator-activated receptors (PPAR-gamma and PPAR-alpha) reduce myocardial infarct size. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20020701 |
| Ligands of the peroxisome proliferator-activated receptor-PPAR-a reduce myocardial infarct size. | Medical science monitor : international medical journal of experimental and clinical research 20020701 |
| Mechanisms involved in responses to the poroxisome proliferator WY-14,643 on gap junctional intercellular communication in V79 hamster fibroblasts. | Toxicology and applied pharmacology 20020701 |
| Advantages of glutamate dehydrogenase as a blood biomarker of acute hepatic injury in rats. | Laboratory animals 20020701 |
| Influence of peroxisome proliferator-activated receptor alpha agonists on the intracellular turnover and secretion of apolipoprotein (Apo) B-100 and ApoB-48. | The Journal of biological chemistry 20020621 |
| Effects of peroxisome proliferator-activated receptor agonists on LPS-induced neuronal death in mixed cortical neurons: associated with iNOS and COX-2. | Brain research 20020621 |
| Gene expression analysis reveals chemical-specific profiles. | Toxicological sciences : an official journal of the Society of Toxicology 20020601 |
| Induction of apoptosis in human and rat glioma by agonists of the nuclear receptor PPARgamma. | Journal of neurochemistry 20020601 |
| Peroxisome proliferator-activated receptor agonists inhibit inflammatory edema and hyperalgesia. | Inflammation 20020601 |
| PPAR activators inhibit endothelial cell migration by targeting Akt. | Biochemical and biophysical research communications 20020524 |
| Involvement of the peroxisome proliferator-activated receptor alpha in the immunomodulation caused by peroxisome proliferators in mice. | Biochemical pharmacology 20020515 |
| Differential effects of gemfibrozil on migration, proliferation and proteoglycan production in human vascular smooth muscle cells. | Atherosclerosis 20020501 |
| Selective inhibition of cyclooxygenase-2 expression by 15-deoxy-Delta(12,14)(12,14)-prostaglandin J(2) in activated human astrocytes, but not in human brain macrophages. | Journal of immunology (Baltimore, Md. : 1950) 20020501 |
| Comparative effects of phthalate monoesters on gap junctional intercellular communication and peroxisome proliferation in rodent and primate hepatocytes. | Journal of toxicology and environmental health. Part A 20020426 |
| PPAR activators as antiinflammatory mediators in human T lymphocytes: implications for atherosclerosis and transplantation-associated arteriosclerosis. | Circulation research 20020405 |
| Peroxisome proliferators activate growth regulatory pathways largely via peroxisome proliferator-activated receptor alpha-independent mechanisms. | Cellular signalling 20020401 |
| Mechanism for peroxisome proliferator-activated receptor-alpha activator-induced up-regulation of UCP2 mRNA in rodent hepatocytes. | The Journal of biological chemistry 20020315 |
| Regulation of cytokine expression by ligands of peroxisome proliferator activated receptors. | Journal of immunology (Baltimore, Md. : 1950) 20020315 |
| Potentiation of TNF-alpha-stimulated group IIA phospholipase A(2) expression by peroxisome proliferator-activated receptor alpha activators in rat mesangial cells. | Journal of the American Society of Nephrology : JASN 20020301 |
| Novel tricyclic-alpha-alkyloxyphenylpropionic acids: dual PPARalpha/gamma agonists with hypolipidemic and antidiabetic activity. | Journal of medicinal chemistry 20020214 |
| The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20020201 |
| Regulation of pyruvate dehydrogenase kinase expression by peroxisome proliferator-activated receptor-alpha ligands, glucocorticoids, and insulin. | Diabetes 20020201 |
| Nimesulide, a preferential cyclooxygenase 2 inhibitor, suppresses peroxisome proliferator-activated receptor induction of cyclooxygenase 2 gene expression in human synovial fibroblasts: evidence for receptor antagonism. | Arthritis and rheumatism 20020201 |
| Characterization of the adipose tissue atrophy induced by peroxisome proliferators in mice. | Lipids 20020201 |
| Microarray analysis of gene expression changes in mouse liver induced by peroxisome proliferator- activated receptor alpha agonists. | Biochemical and biophysical research communications 20020125 |
| PPARalpha and PPARdelta activators inhibit cytokine-induced nuclear translocation of NF-kappaB and expression of VCAM-1 in EAhy926 endothelial cells. | European journal of pharmacology 20020125 |
| Characterization of an acyl-coA thioesterase that functions as a major regulator of peroxisomal lipid metabolism. | The Journal of biological chemistry 20020111 |
| Topical peroxisome proliferator activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models. | The Journal of investigative dermatology 20020101 |
| Effect of peroxisome proliferators on the methylation and protein level of the c-myc protooncogene in B6C3F1 mice liver. | Journal of biochemical and molecular toxicology 20020101 |
| Profiling of acyl-CoA oxidase-deficient and peroxisome proliferator Wy14,643-treated mouse liver protein by surface-enhanced laser desorption/ionization ProteinChip Biology System. | Gene expression 20020101 |
| The transcription of the peroxisome proliferator-activated receptor alpha gene is regulated by protein kinase C. | Toxicology letters 20011215 |
| Antagonism of the actions of peroxisome proliferator-activated receptor-alpha by bile acids. | The Journal of biological chemistry 20011214 |
| Selective modification of pyruvate dehydrogenase kinase isoform expression in rat pancreatic islets elicited by starvation and activation of peroxisome proliferator-activated receptor-alpha: implications for glucose-stimulated insulin secretion. | Diabetes 20011201 |
| Peroxisome proliferator-activated receptor alpha (PPAR alpha) agonist, WY-14,643, increased transcription of myosin light chain-2 in cardiomyocytes. | The Journal of toxicological sciences 20011201 |
| Activators of peroxisome proliferator-activated receptors protect human skin from ultraviolet-B-light-induced inflammation. | The Journal of investigative dermatology 20011201 |
| Reactivation of peroxisome proliferator-activated receptor alpha is associated with contractile dysfunction in hypertrophied rat heart. | The Journal of biological chemistry 20011130 |
| Human peroxisome proliferator-activated receptor alpha (PPARalpha) supports the induction of peroxisome proliferation in PPARalpha-deficient mouse liver. | The Journal of biological chemistry 20011109 |
| Hepatocellular proliferation in response to a peroxisome proliferator does not require TNFalpha signaling. | Carcinogenesis 20011101 |
| Fibrates suppress bile acid synthesis via peroxisome proliferator-activated receptor-alpha-mediated downregulation of cholesterol 7alpha-hydroxylase and sterol 27-hydroxylase expression. | Arteriosclerosis, thrombosis, and vascular biology 20011101 |
| Limited cooperation between peroxisome proliferator-activated receptors and retinoid X receptor agonists in sebocyte growth and development. | Molecular genetics and metabolism 20011101 |
| Peroxisome proliferator-activated receptor-alpha regulates lipid homeostasis, but is not associated with obesity: studies with congenic mouse lines. | The Journal of biological chemistry 20011019 |
| Stabilization of peroxisome proliferator-activated receptor alpha by the ligand. | Biochemical and biophysical research communications 20011019 |
| Activation of the peroxisome proliferator-activated receptor-alpha enhances cell death in cultured cerebellar granule cells. | Journal of neuroscience research 20011015 |
| Adaptive increase in pyruvate dehydrogenase kinase 4 during starvation is mediated by peroxisome proliferator-activated receptor alpha. | Biochemical and biophysical research communications 20010921 |
| Comparison of the mutant frequencies and mutation spectra of three non-genotoxic carcinogens, oxazepam, phenobarbital, and Wyeth 14,643, at the lambdacII locus in Big Blue transgenic mice. | Biochemical pharmacology 20010915 |
| Negative regulation of human fibrinogen gene expression by peroxisome proliferator-activated receptor alpha agonists via inhibition of CCAAT box/enhancer-binding protein beta. | The Journal of biological chemistry 20010907 |
| Phenobarbital, oxazepam and Wyeth 14,643 cause DNA damage as measured by the Comet assay. | Mutagenesis 20010901 |
| Differential regulation of adipocytokine mRNAs by rosiglitazone in db/db mice. | Biochemical and biophysical research communications 20010831 |
| Effects of bezafibrate on beta-cell function of rat pancreatic islets. | European journal of pharmacology 20010831 |
| Altered expression of the carboxylesterases ES-4 and ES-10 by peroxisome proliferator chemicals. | Toxicology 20010828 |
| Regulation of p85alpha phosphatidylinositol-3-kinase expression by peroxisome proliferator-activated receptors (PPARs) in human muscle cells. | FEBS letters 20010803 |
| (-)3-[4-[2-(Phenoxazin-10-yl)ethoxy]phenyl]-2-ethoxypropanoic acid [(-)DRF 2725]: a dual PPAR agonist with potent antihyperglycemic and lipid modulating activity. | Journal of medicinal chemistry 20010802 |
| Peroxisome proliferator-activated receptor-alpha ligands inhibit cardiac lipoprotein lipase activity. | American journal of physiology. Heart and circulatory physiology 20010801 |
| PPARalpha-dependent induction of liver microsomal esterification of estradiol and testosterone by a prototypical peroxisome proliferator. | Endocrinology 20010801 |
| Identification of peroxisome proliferator-responsive human genes by elevated expression of the peroxisome proliferator-activated receptor alpha in HepG2 cells. | The Journal of biological chemistry 20010727 |
| Identification of a peroxisome-proliferator-activated-receptor response element in the apolipoprotein E gene control region. | The Biochemical journal 20010715 |
| Inhibitors of arachidonic acid metabolism potentiate tumour necrosis factor-alpha-induced apoptosis in HL-60 cells. | European journal of pharmacology 20010713 |
| Differential activation of hepatic NF-kappaB in rats and hamsters by the peroxisome proliferators Wy-14,643, gemfibrozil, and dibutyl phthalate. | Toxicological sciences : an official journal of the Society of Toxicology 20010701 |
| Wy-14,643-induced hypomethylation of the c-myc gene in mouse liver. | Toxicological sciences : an official journal of the Society of Toxicology 20010701 |
| Effect of PPAR activators on cytokine-stimulated cyclooxygenase-2 expression in human colorectal carcinoma cells. | Experimental cell research 20010701 |
| Cloning of the human cholesteryl ester hydrolase promoter: identification of functional peroxisomal proliferator-activated receptor responsive elements. | Biochemical and biophysical research communications 20010622 |
| Hypoxia-inducible factor 1-mediated inhibition of peroxisome proliferator-activated receptor alpha expression during hypoxia. | Journal of immunology (Baltimore, Md. : 1950) 20010615 |
| Evidence that reduction of hepatocyte growth factor (HGF) is not required for peroxisome proliferator-induced hepatocyte proliferation. | Carcinogenesis 20010601 |
| The short heterodimer partner receptor differentially modulates peroxisome proliferator-activated receptor alpha-mediated transcription from the peroxisome proliferator-response elements of the genes encoding the peroxisomal beta-oxidation enzymes acyl-CoA oxidase and hydratase-dehydrogenase. | Molecular and cellular endocrinology 20010515 |
| Mono-(2-ethylhexyl) phthalate suppresses aromatase transcript levels and estradiol production in cultured rat granulosa cells. | Toxicology and applied pharmacology 20010501 |
| PPARalpha deficiency reduces insulin resistance and atherosclerosis in apoE-null mice. | The Journal of clinical investigation 20010415 |
| Effects of peroxisome proliferators on antioxidant enzymes and antioxidant vitamins in rats and hamsters. | Toxicological sciences : an official journal of the Society of Toxicology 20010401 |
| Differential regulation of expression of genes encoding uncoupling proteins 2 and 3 in brown adipose tissue during lactation in mice. | The Biochemical journal 20010401 |
| The nuclear receptor PPAR gamma is expressed by mouse T lymphocytes and PPAR gamma agonists induce apoptosis. | European journal of immunology 20010401 |
| WY-14,643 and other agonists of the peroxisome proliferator-activated receptor reveal a new mode of action for salicylic acid in soybean disease resistance. | Planta 20010401 |
| Peroxisome proliferators and fatty acids negatively regulate liver X receptor-mediated activity and sterol biosynthesis. | The Journal of steroid biochemistry and molecular biology 20010401 |
| Regulation of cardiac and skeletal muscle malonyl-CoA decarboxylase by fatty acids. | American journal of physiology. Endocrinology and metabolism 20010301 |
| Mechanisms of extrahepatic tumor induction by peroxisome proliferators in male CD rats. | Toxicological sciences : an official journal of the Society of Toxicology 20010301 |
| Tumor necrosis factor alpha is not required for WY14,643-induced cell proliferation. | Carcinogenesis 20010301 |
| Peroxisome proliferators do not increase DNA synthesis in purified rat hepatocytes. | Carcinogenesis 20010301 |
| Uncoupling protein 3 transcription is regulated by peroxisome proliferator-activated receptor (alpha) in the adult rodent heart. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010301 |
| Effects of peroxisome proliferators on glutathione and glutathione-related enzymes in rats and hamsters. | Toxicology and applied pharmacology 20010215 |
| Delayed activation of PPARgamma by LPS and IFN-gamma attenuates the oxidative burst in macrophages. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010201 |
| PPARalpha agonists inhibit tissue factor expression in human monocytes and macrophages. | Circulation 20010116 |
| PPARalpha activators inhibit tissue factor expression and activity in human monocytes. | Circulation 20010116 |
| Fatty-acyl-CoA thioesters inhibit recruitment of steroid receptor co-activator 1 to alpha and gamma isoforms of peroxisome-proliferator-activated receptors by competing with agonists. | The Biochemical journal 20010115 |
| Dexamethasone selectively inhibits WY14,643-induced cell proliferation and not peroxisome proliferation in mice. | Toxicology and applied pharmacology 20010115 |
| Abundant expression of uncoupling protein-2 in the small intestine: up-regulation by dietary fish oil and fibrates. | Biochimica et biophysica acta 20010115 |
| Peroxisome proliferator-activated receptor alpha activates transcription of the brown fat uncoupling protein-1 gene. A link between regulation of the thermogenic and lipid oxidation pathways in the brown fat cell. | The Journal of biological chemistry 20010112 |
| The transcriptional and DNA binding activity of peroxisome proliferator-activated receptor alpha is inhibited by ethanol metabolism. A novel mechanism for the development of ethanol-induced fatty liver. | The Journal of biological chemistry 20010105 |
| Expression of the mRNA encoding truncated PPAR alpha does not correlate with hepatic insensitivity to peroxisome proliferators. | Molecular and cellular biochemistry 20010101 |
| Therapeutic treatment of DMBA-induced mammary tumors with PPAR ligands. | Anticancer research 20010101 |
| Unique renal tubule changes induced in rats and mice by the peroxisome proliferators 2,4-dichlorophenoxyacetic acid (2,4-D) and WY-14643. | Toxicologic pathology 20010101 |
| Identification of novel peroxisome proliferator-activated receptor alpha (PPARalpha) target genes in mouse liver using cDNA microarray analysis. | Gene expression 20010101 |
| 15-Deoxy-Delta(12,14)-prostaglandin J(2) facilitates thyroglobulin production by cultured human thyrocytes. | American journal of physiology. Cell physiology 20001201 |
| Down-regulation of uncoupling protein-3 and -2 by thiazolidinediones in C2C12 myotubes. | FEBS letters 20001027 |
| Keratinocyte differentiation in hyperproliferative epidermis: topical application of PPARalpha activators restores tissue homeostasis. | The Journal of investigative dermatology 20000901 |
| Peroxisome proliferator-activated receptor alpha (PPARalpha) activators, bezafibrate and Wy-14,643, increase uncoupling protein-3 mRNA levels without modifying the mitochondrial membrane potential in primary culture of rat preadipocytes. | Archives of biochemistry and biophysics 20000815 |
| Impaired expression of the uncoupling protein-3 gene in skeletal muscle during lactation: fibrates and troglitazone reverse lactation-induced downregulation of the uncoupling protein-3 gene. | Diabetes 20000701 |
| Evidence against the peroxisome proliferator-activated receptor alpha (PPARalpha) as the mediator for polyunsaturated fatty acid suppression of hepatic L-pyruvate kinase gene transcription. | Journal of lipid research 20000501 |
| The PPARs: from orphan receptors to drug discovery. | Journal of medicinal chemistry 20000224 |
| The effect of the trichloroethylene metabolites trichloroacetate and dichloroacetate on peroxisome proliferation and DNA synthesis in cultured human hepatocytes. | Cell biology and toxicology 20000101 |
| trans-Activation of PPARalpha and PPARgamma by structurally diverse environmental chemicals. | Toxicology and applied pharmacology 19991201 |
| PPARalpha activation by Wy 14643 induces transactivation of the rat UCP-1 promoter without increasing UCP-1 mRNA levels and attenuates PPARgamma-mediated increases in UCP-1 mRNA levels induced by rosiglitazone in fetal rat brown adipocytes. | Biochemical and biophysical research communications 19991022 |
| Altered bcl-2 family expression during non-genotoxic hepatocarcinogenesis in mice. | Carcinogenesis 19990801 |
| Evidence for direct binding of fatty acids and eicosanoids to human peroxisome proliferators-activated receptor alpha. | Biochemical and biophysical research communications 19990714 |
| Rosiglitazone (BRL49653), a PPARgamma-selective agonist, causes peroxisome proliferator-like liver effects in obese mice. | Journal of lipid research 19990701 |
| Activators of peroxisome proliferator-activated receptor-alpha induce the expression of the uncoupling protein-3 gene in skeletal muscle: a potential mechanism for the lipid intake-dependent activation of uncoupling protein-3 gene expression at birth. | Diabetes 19990601 |
| Effects of fibrate compounds on expression of plasminogen activator inhibitor-1 by cultured endothelial cells. | Arteriosclerosis, thrombosis, and vascular biology 19990601 |
| A novel insulin sensitizer acts as a coligand for peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and PPAR-gamma: effect of PPAR-alpha activation on abnormal lipid metabolism in liver of Zucker fatty rats. | Diabetes 19981201 |
| Fibrate-modulated expression of fibrinogen, plasminogen activator inhibitor-1 and apolipoprotein A-I in cultured cynomolgus monkey hepatocytes -- role of the peroxisome proliferator-activated receptor-alpha. | Thrombosis and haemostasis 19981201 |
| Activation of peroxisome proliferator-activated receptors by chlorinated hydrocarbons and endogenous steroids. | Environmental health perspectives 19980801 |
| Dietary glycine prevents increases in hepatocyte proliferation caused by the peroxisome proliferator WY-14,643. | Chemical research in toxicology 19971001 |
| PPAR alpha structure-function relationships derived from species-specific differences in responsiveness to hypolipidemic agents. | Biological chemistry 19970701 |
| Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs. | The Journal of biological chemistry 19970207 |
| Induction of cyclooxygenase-2 expression by peroxisome proliferators and non-tetradecanoylphorbol 12,13-myristate-type tumor promoters in immortalized mouse liver cells. | The Journal of biological chemistry 19970207 |
| Peroxisome proliferators alter the expression of estrogen-metabolizing enzymes. | Biochimie 19970101 |
| Molecular profiling of non-genotoxic hepatocarcinogenesis using differential display reverse transcription-polymerase chain reaction (ddRT-PCR). | European journal of drug metabolism and pharmacokinetics 19970101 |
| The PPARalpha-leukotriene B4 pathway to inflammation control. | Nature 19961107 |
| Growth regulation by peroxisome proliferators: opposing activities in early and late G1. | Cancer research 19960715 |
| Peroxisome proliferator-activated receptor alpha required for gene induction by dehydroepiandrosterone-3 beta-sulfate. | Molecular pharmacology 19960701 |
| A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. | Cell 19951201 |
| Gemfibrozil-induced peroxisome proliferation and hepatomegaly in male F344 rats. | Cancer letters 19951106 |
| Negative regulation of the human apolipoprotein A-I promoter by fibrates can be attenuated by the interaction of the peroxisome proliferator-activated receptor with its response element. | The Journal of biological chemistry 19941209 |
| Initiator-specific promotion of hepatocarcinogenesis by WY-14,643 and clofibrate. | Carcinogenesis 19940801 |
| Proliferating cell nuclear antigen: a marker for hepatocellular proliferation in rodents. | Environmental health perspectives 19931201 |
| cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor. | Biochemistry 19930601 |
| Loss of peroxisomal enzyme expression in preneoplastic and neoplastic lesions induced by peroxisome proliferators in rat livers. | Carcinogenesis 19920201 |
| Peroxisome proliferator-induced alterations in the expression and modification of rat hepatocyte plasma membrane proteins. | Cancer research 19900201 |
| Reversible alteration in the expression of the gap junctional protein connexin 32 during tumor promotion in rat liver and its role during cell proliferation. | Cancer communications 19900101 |
| Lack of expression of glutathione-S-transferase P, gamma-glutamyl transpeptidase, and alpha-fetoprotein messenger RNAs in liver tumors induced by peroxisome proliferators. | Cancer research 19880901 |
| Peroxisome proliferation in primary cultures of rat hepatocytes. | Toxicology and applied pharmacology 19830101 |
| Enhancement by Wy-14,643, a hepatic peroxisome proliferator, of diethylnitrosamine-initiated hepatic tumorigenesis in the rat. | British journal of cancer 19781001 |
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