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504-75-6

504-75-6 | 4,5-dihydro-1H-imidazole

CAS No: 504-75-6 Catalog No: AG00DU7D MDL No:MFCD03308681

Product Description

Catalog Number:
AG00DU7D
Chemical Name:
4,5-dihydro-1H-imidazole
CAS Number:
504-75-6
Molecular Formula:
C3H6N2
Molecular Weight:
70.0931
MDL Number:
MFCD03308681
IUPAC Name:
4,5-dihydro-1H-imidazole
InChI:
InChI=1S/C3H6N2/c1-2-5-3-4-1/h3H,1-2H2,(H,4,5)
InChI Key:
MTNDZQHUAFNZQY-UHFFFAOYSA-N
SMILES:
C1CNC=N1
EC Number:
207-999-4
UNII:
D36R5YLK6R

Properties

Complexity:
48.9  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
70.053g/mol
Formal Charge:
0
Heavy Atom Count:
5  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
70.095g/mol
Monoisotopic Mass:
70.053g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
24.4A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-0.8  

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Recovered changes in the spleen by agmatine treatment after transient cerebral ischemia. Anatomy & cell biology 20100301
Self-assembly of discrete homochiral, helical, hydrogen-bonded nanocages: from vesicles to microspheres and tubules capable of gelating solvents. Chemistry (Weinheim an der Bergstrasse, Germany) 20100215
One-pot electrosynthesis of substituted imidazolinium and tetrahydropyrimidinium salts from secondary alkyldiamines: an electrochemical route toward ionic liquids. The Journal of organic chemistry 20100205
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Agmatine transport in brain mitochondria: a different mechanism from that in liver mitochondria. Amino acids 20100201
Characterization of the postconditioning effect of dexmedetomidine in mouse organotypic hippocampal slice cultures exposed to oxygen and glucose deprivation. Anesthesiology 20100201
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A comparative kinetic and mechanistic study between tetrahydrozoline and naphazoline toward photogenerated reactive oxygen species. Photochemistry and photobiology 20100101
Ocular hypotensive effects of topically administered agmatine in a chronic ocular hypertensive rat model. Experimental eye research 20100101
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Controlling the coordination modes of a new and highly flexible ligand bearing two N-heterocyclic carbene moieties at a bipyridine backbone. Dalton transactions (Cambridge, England : 2003) 20090921
Stable crystalline annulated diaminocarbenes: coordination with rhodium(I), iridium(I) and catalytic hydroformylation studies. Dalton transactions (Cambridge, England : 2003) 20090921
Antidepressant like effect of selective serotonin reuptake inhibitors involve modulation of imidazoline receptors by agmatine. Neuropharmacology 20090901
Discovery of pyridone-containing imidazolines as potent and selective inhibitors of neuropeptide Y Y5 receptor. Bioorganic & medicinal chemistry 20090815
Abstracts of the 2008 ISSOL Meeting. August 24-29, 2008. Florence, Italy. Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life 20090801
Synthesis and cytotoxic activity of novel amidine analogues of bis(2-chloroethyl)amine. Archiv der Pharmazie 20090801
Clonidine in perioperative medicine and intensive care unit: more than an anti-hypertensive drug. Current drug targets 20090801
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High-throughput reaction optimisation and activity screening of ferrocene-based Lewis acid-catalyst complexes by using continuous-flow reaction detection mass spectrometry. Chemistry (Weinheim an der Bergstrasse, Germany) 20090727
Identification of an imidazoline binding protein: creatine kinase and an imidazoline-2 binding site. Brain research 20090707
Activation of I2-imidazoline receptors by agmatine improved insulin sensitivity through two mechanisms in type-2 diabetic rats. Neuroscience letters 20090703
Monodentate non-C(2)-symmetric chiral N-heterocyclic carbene complexes for enantioselective synthesis. Cu-catalyzed conjugate additions of aryl- and alkenylsilylfluorides to cyclic enones. The Journal of organic chemistry 20090619
Comparison of agmatine with moxonidine and rilmenidine in morphine dependence in vitro: role of imidazoline I(1) receptors. European journal of pharmacology 20090610
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Discovery of tetrasubstituted imidazolines as potent and selective neuropeptide Y Y5 receptor antagonists: reduced human ether-a-go-go related gene potassium channel binding affinity and potent antiobesity effect. Journal of medicinal chemistry 20090528
One-carbon extrusion from a tetraazafulvalene. Isolation of aldehydes and a study of their origin. Journal of the American Chemical Society 20090513
The effects of synthetic and endogenous imidazoline binding site ligands on neuronal activity in discrete brain regions of naive and restraint-stressed rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20090501
Hemodynamic and cardiac effects of chronic eprosartan and moxonidine therapy in stroke-prone spontaneously hypertensive rats. Hypertension (Dallas, Tex. : 1979) 20090501
Chemical vectors for gene delivery: a current review on polymers, peptides and lipids containing histidine or imidazole as nucleic acids carriers. British journal of pharmacology 20090501
Attenuation of ischemia-induced rat brain injury by 2-(-2-benzofuranyl)-2-imidazoline, a high selectivity ligand for imidazoline I(2) receptors. Neurological research 20090501
Structural-activity relationship study of highly-functionalized imidazolines as potent inhibitors of nuclear transcription factor-kappaB mediated IL-6 production. Bioorganic & medicinal chemistry 20090415
Involvement of central alpha1-adrenoceptors on renal responses to central moxonidine and alpha-methylnoradrenaline. European journal of pharmacology 20090401
Effect of moxonidine on the uveoscleral outflow: role of alpha2-adrenoceptors or i1 imidazoline receptors. Current eye research 20090401
2-p-Tolyl-4,5-dihydro-1H-imidazole. Acta crystallographica. Section E, Structure reports online 20090401
2-(4,5-Dihydro-1H-imidazol-2-yl)-pyridine. Acta crystallographica. Section E, Structure reports online 20090401
2-(4-Methoxy-phen-yl)-4,5-dihydro-1H-imidazole. Acta crystallographica. Section E, Structure reports online 20090401
An experimental and theoretical study on the interaction of N-heterocyclic carbene-derived 1,3-dipoles with methoxycarbonylallenes: highly regio- and stereoselective [3+2]-cycloadditions controlled by the structures of N-heterocycles of 1,3-dipoles. The Journal of organic chemistry 20090320
Discovery of substituted 2,4,4-triarylimidazoline derivatives as potent and selective neuropeptide Y Y5 receptor antagonists. Bioorganic & medicinal chemistry letters 20090315
Nuclear factor-kappaB mediated inhibition of cytokine production by imidazoline scaffolds. Journal of medicinal chemistry 20090312
Imidazoline-induced amplification of glucose- and carbachol-stimulated insulin release includes a marked suppression of islet nitric oxide generation in the mouse. Acta physiologica (Oxford, England) 20090301
Modulation of stress by imidazoline binding sites: implications for psychiatric disorders. Stress (Amsterdam, Netherlands) 20090301
Alpha 2A-adrenergic receptor signaling underlies synergistic enhancement of ethanol-induced behavioral impairment by clonidine. Alcoholism, clinical and experimental research 20090301
Testing conception of engagement of imidazoline receptors in imidazoline drugs effects on isolated rat heart atria. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20090301
A modular synthesis of highly substituted imidazolium salts. Organic letters 20090219
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Activation of alpha(2)-adrenoceptors in the lateral hypothalamus reduces pilocarpine-induced salivation in rats. Neuroscience letters 20090206
The effect of clonidine on VEGF expression in human retinal pigment epithelial cells (ARPE-19). Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20090201
New analogues of agmatine with higher affinity to imidazoline receptors. Bioorganic & medicinal chemistry letters 20090201
The analgesic effect of epidural clonidine after spinal surgery: a randomized placebo-controlled trial. Anesthesia and analgesia 20090201
1,3-Bis(2-thienylmeth-yl)-4,5-dihydro-imidazolium trichlorido(η-p-cymene)ruthenate(II). Acta crystallographica. Section E, Structure reports online 20090201
2-(2-Thien-yl)-4,5-dihydro-1H-imidazole. Acta crystallographica. Section E, Structure reports online 20090201
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Preventive mechanisms of agmatine against ischemic acute kidney injury in rats. European journal of pharmacology 20090128
Chronic ethanol attenuates centrally-mediated hypotension elicited via alpha(2)-adrenergic, but not I(1)-imidazoline, receptor activation in female rats. Life sciences 20090116
Ultrasound promoted synthesis of 2-imidazolines in water: a greener approach toward monoamine oxidase inhibitors. Bioorganic & medicinal chemistry letters 20090115
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Robust and electron-rich cis-palladium(II) complexes with phosphine and carbene ligands as catalytic precursors in Suzuki coupling reactions. Chemistry (Weinheim an der Bergstrasse, Germany) 20090101
Determination of adrenergic and imidazoline receptor involvement in augmentation of morphine and oxycodone analgesia by clonidine and BMS182874. Pharmacology 20090101
QSAR study of selective I1-imidazoline receptor ligands. SAR and QSAR in environmental research 20090101
Generation and characterization of novel human IRAS monoclonal antibodies. Journal of biomedicine & biotechnology 20090101
Sedation improves early outcome in severely septic Sprague Dawley rats. Critical care (London, England) 20090101
A phase II clinical trial to assess the safety of clonidine in acute organophosphorus pesticide poisoning. Trials 20090101
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Engineered G-protein Coupled Receptors are Powerful Tools to Investigate Biological Processes and Behaviors. Frontiers in molecular neuroscience 20090101
Synthesis and biological activity of some 2-imidazolinylhydrazone derivatives. Acta poloniae pharmaceutica 20090101
Protection in glutamate-induced neurotoxicity by imidazoline receptor agonist moxonidine. The International journal of neuroscience 20090101
2-[(Arylmethoxy)imino]imidazolidines with potential biological activities. Acta poloniae pharmaceutica 20090101
Implication of enterohepatic re-circulation on single dose bioequivalence evaluation of two brands of clonidine hydrochloride tablets in healthy human volunteers. Indian journal of pharmaceutical sciences 20090101
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Antitumor agents 6. Synthesis, structure-activity relationships, and biological evaluation of spiro[imidazolidine-4,3'-thieno[2,3-g]quinoline]-tetraones and spiro[thieno[2,3-g]quinoline-3,5'-[1,2,4]triazinane]-tetraones with potent antiproliferative activity. Journal of medicinal chemistry 20081225
Activation of I(2)-imidazoline receptors may ameliorate insulin resistance in fructose-rich chow-fed rats. Neuroscience letters 20081219
On the racemization of chiral imidazolines. The Journal of organic chemistry 20081219
Synthesis and biological activities of novel nonpeptide angiotensin II receptor antagonists based on benzimidazole derivatives bearing a heterocyclic ring. Bioorganic & medicinal chemistry 20081215
Evidence that some imidazoline derivatives inhibit peripherally the vasopressor sympathetic outflow in pithed rats. Autonomic neuroscience : basic & clinical 20081205
Effect of agmatine on DAMGO-induced mu-opioid receptor down-regulation and internalization via activation of IRAS, a candidate for imidazoline I(1) receptor. European journal of pharmacology 20081203
Autophagy in neurodegeneration and development. Biochimica et biophysica acta 20081201
Biphasic dose-dependent modulation of cardiac parasympathetic activity by moxonidine, an imidazoline I1-receptor agonist. Journal of cardiovascular pharmacology 20081201
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Photomodulation of ionic interaction and reactivity: reversible photoconversion between imidazolium and imidazolinium. Journal of the American Chemical Society 20081105
Hidden histidine radical rearrangements upon electron transfer to gas-phase peptide ions. Experimental evidence and theoretical analysis. Journal of the American Chemical Society 20081105
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Online screening of homogeneous catalyst performance using reaction detection mass spectrometry. Analytical chemistry 20080915
Functional neuroanatomy of the noradrenergic locus coeruleus: its roles in the regulation of arousal and autonomic function part I: principles of functional organisation. Current neuropharmacology 20080901
Functional neuroanatomy of the noradrenergic locus coeruleus: its roles in the regulation of arousal and autonomic function part II: physiological and pharmacological manipulations and pathological alterations of locus coeruleus activity in humans. Current neuropharmacology 20080901
Novel ligands rationally designed for characterizing I2-imidazoline binding sites nature and functions. Journal of medicinal chemistry 20080828
Mechanism of Ca2+-influx and Ca2+/calmodulin-dependent protein kinase IV activity during in utero hypoxia in cerebral cortical neuronal nuclei of the guinea pig fetus at term. Neuroscience letters 20080808
Agmatine and imidazoline receptors: their role in opioid analgesia, tolerance and dependence. Cellular and molecular neurobiology 20080801
QSAR study of imidazoline antihypertensive drugs. Bioorganic & medicinal chemistry 20080801
Imidazoline I(1) receptor-mediated reduction of muscle rigidity in the reserpine-treated murine model of Parkinson's disease. European journal of pharmacology 20080728
Synthetic studies towards a new scaffold, spirobicycloimidazoline. Carbohydrate research 20080721
Metabolic factors and risk of hepatocellular carcinoma by chronic hepatitis B/C infection: a follow-up study in Taiwan. Gastroenterology 20080701
1-[(Imidazolidin-2-yl)imino]indazole. Highly alpha 2/I1 selective agonist: synthesis, X-ray structure, and biological activity. Journal of medicinal chemistry 20080626
Effects of spinal alpha(2)-adrenoceptor and I(1)-imidazoline receptor activation on hindlimb movement induction in spinal cord-injured mice. The Journal of pharmacology and experimental therapeutics 20080601
Indolealkylamines: biotransformations and potential drug-drug interactions. The AAPS journal 20080601
Synthesis and antiproliferative activity of imidazole and imidazoline analogs for melanoma. Bioorganic & medicinal chemistry letters 20080601
[Imidazoline receptor]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20080601
Once-daily treatment of ADHD with guanfacine: patient implications. Neuropsychiatric disease and treatment 20080601
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A facile preparation of imidazolinium chlorides. Organic letters 20080515
Proteins in the insulin-secreting cell line MIN6 bind the imidazoline compound BL11282. FEBS letters 20080514
Caffeine and a selective adenosine A(2B) receptor antagonist but not imidazoline receptor antagonists modulate antinociception induced by diphenyl diselenide in mice. Neuroscience letters 20080509
Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nature chemical biology 20080501
G-protein inwardly rectifying potassium channels are involved in the hypotensive effect of I1-imidazoline receptor selective ligands. Journal of hypertension 20080501
The antiarrhythmic effect of centrally administered rilmenidine involves muscarinic receptors, protein kinase C and mitochondrial signalling pathways. British journal of pharmacology 20080401
Spectrofluorimetric determination of oxamniquine in dosage forms and spiked human plasma through derivatization with 1-dimethylaminonaphthalene-5-sulphonyl chloride. Journal of fluorescence 20080301
Dexmedetomidine increases hippocampal phosphorylated extracellular signal-regulated protein kinase 1 and 2 content by an alpha 2-adrenoceptor-independent mechanism: evidence for the involvement of imidazoline I1 receptors. Anesthesiology 20080301
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Multiple binding sites for substrates and modulators of semicarbazide-sensitive amine oxidases: kinetic consequences. Molecular pharmacology 20080201
Control of left ventricular mass by moxonidine involves reduced DNA synthesis and enhanced DNA fragmentation. British journal of pharmacology 20080201
A novel synthesis of chiral guanidinium receptors and their use in unfolding the energetics of enantiorecognition of chiral carboxylates. The Journal of organic chemistry 20080201
A practical overview of tizanidine use for spasticity secondary to multiple sclerosis, stroke, and spinal cord injury. Current medical research and opinion 20080201
N-nitrosotolazoline: decomposition studies of a typical N-nitrosoimidazoline. Chemical research in toxicology 20080201
Nucleoside and DNA adducts from N-nitrosotolazoline. Chemical research in toxicology 20080201
Prolonged cardiovascular effects after unintentional ingestion of tetrahydrozoline. Clinical toxicology (Philadelphia, Pa.) 20080201
Adenylyl cyclase-cyclicAMP signaling in mood disorders: role of the crucial phosphorylating enzyme protein kinase A. Neuropsychiatric disease and treatment 20080201
Efficient C2 functionalisation of 2H-2-imidazolines. Organic & biomolecular chemistry 20080107
Platelet imidazoline receptors as state marker of depressive symptomatology. Journal of psychiatric research 20080101
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Paracrinicity: the story of 30 years of cellular pituitary crosstalk. Journal of neuroendocrinology 20080101
Dexmedetomidine reduces long-term potentiation in mouse hippocampus. Anesthesiology 20080101
N-heterocyclic carbene ligands in copper-catalyzed addition of diethylzinc to N-sulfonylimines. Chemical & pharmaceutical bulletin 20080101
Antihypertensive drug guanabenz is active in vivo against both yeast and mammalian prions. PloS one 20080101
A test of highly optimized tolerance reveals fragile cell-cycle mechanisms are molecular targets in clinical cancer trials. PloS one 20080101
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Alpha-2 adrenergic-induced changes in rectal temperature in adult and 13-day old rats following acute and repeated desipramine administration. BMC pharmacology 20080101
Facile microwave-assisted synthesis of cyclic amidinium salts. Journal of combinatorial chemistry 20080101
Evaluation of Dimebon in cellular model of Huntington's disease. Molecular neurodegeneration 20080101
Preferential formation of homochiral helical sandwich-shaped architectures through the metal-mediated assembly of tris(imidazoline) ligands with a set of d(3)-d(10) transition-metal ions. Chemistry (Weinheim an der Bergstrasse, Germany) 20080101
Effects of agmatine on nicotine-evoked behavioral responses in rats. Pharmacological reports : PR 20080101
(E)-Benzo-yl[1-(2-hydroxy-ethyl)imidazolidin-2-yl-idene]acetonitrile. Acta crystallographica. Section E, Structure reports online 20080101
Synthesis and characterization of ruthenium bis(beta-diketonato) pyridine-imidazole complexes for hydrogen atom transfer. Inorganic chemistry 20071224
Exploration of liquid and supercritical fluid chromatographic chiral separation and purification of Nutlin-3--a small molecule antagonist of MDM2. Journal of pharmaceutical and biomedical analysis 20071221
Dual-acting agents that possess reversing resistance and anticancer activities: Design, synthesis, MES-SA/Dx5 cell assay, and SAR of Benzyl 1,2,3,5,11,11a-hexahydro-3,3-dimethyl-1-oxo-6H-imidazo[3',4':1,2]pyridin[3,4-b]indol-2-substitutedacetates. Bioorganic & medicinal chemistry 20071215
S1P-receptors in PC12 and transfected HEK293 cells: molecular targets of hypotensive imidazoline I(1) receptor ligands. Neurochemistry international 20071201
Agmatine inhibits morphine-induced locomotion sensitization and morphine-induced changes in striatal dopamine and metabolites in rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20071201
Clonidine accumulation in human neuronal cells. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20071201
Peroxynitrite is Involved in the dysfunction of vasorelaxation in SHR/NDmcr-cp rats, spontaneously hypertensive obese rats. Journal of cardiovascular pharmacology 20071201
Photolysis pathway of imazapic in aqueous solution: ultrahigh resolution mass spectrometry analysis of intermediates. Journal of agricultural and food chemistry 20071128
Arachidonic acid signaling is involved in the mechanism of imidazoline-induced KATP channel-independent stimulation of insulin secretion. Cellular and molecular life sciences : CMLS 20071101
Sympathoexcitation of moxonidine in the caudal ventrolateral medulla is dependent on I1-imidazoline receptors in anesthetized rats. Neuroscience letters 20071016
Treatment of hypertension in patients with diabetes mellitus : relevance of sympathovagal balance and renal function. Clinical research in cardiology : official journal of the German Cardiac Society 20071001
Potassium- and capsaicin-induced release of agmatine from spinal nerve terminals. Journal of neurochemistry 20070901
Agmatine induces antihyperalgesic effects in diabetic rats and a superadditive interaction with R(-)-3-(2-carboxypiperazine-4-yl)-propyl-1-phosphonic acid, a N-methyl-D-aspartate-receptor antagonist. The Journal of pharmacology and experimental therapeutics 20070901
Comparative study of NMDA and AMPA/kainate receptors involved in cardiovascular inhibition produced by imidazoline-like drugs in anaesthetized rats. Experimental physiology 20070901
Contribution of AMPA/kainate receptors in the rostral ventrolateral medulla to the hypotensive and sympathoinhibitory effects of clonidine. American journal of physiology. Regulatory, integrative and comparative physiology 20070901
The molecular genetics of breast cancer and targeted therapy. Biologics : targets & therapy 20070901
A resource-efficient and highly flexible procedure for a three-component synthesis of 2-imidazolines. The Journal of organic chemistry 20070803
Highly efficient and site-selective [3 + 2] cycloaddition of carbene-derived ambident dipoles with ketenes for a straightforward synthesis of spiro-pyrrolidones. The Journal of organic chemistry 20070803
Sulfonated N-heterocyclic carbenes for Suzuki coupling in water. Chemical communications (Cambridge, England) 20070719
The effect of 1-(4,5-dihydro-1H-imidazol-2-yl) isoquinoline on monoamine release and turnover in the rat frontal cortex. Neuroscience letters 20070711
Possible role of NMDA receptors in antinociception induced by rilmenidine in mice in the formalin test. European journal of pain (London, England) 20070701
Drug facilitated sexual assault using an over-the-counter ocular solution containing tetrahydrozoline (Visine). Legal medicine (Tokyo, Japan) 20070701
MHP-133, a drug with multiple CNS targets: potential for neuroprotection and enhanced cognition. Neurochemical research 20070701
Effects of sympatholytic therapy on insulin sensitivity indices in hypertensive postmenopausal women. International journal of clinical pharmacology and therapeutics 20070701
Evidence for imidazoline receptors involvement in the agmatine antidepressant-like effect in the forced swimming test. European journal of pharmacology 20070622
Agmatine blocks morphine-evoked hyperthermia in rats. Brain research 20070525
Design, synthesis, and biological evaluation of substituted-N-(thieno[2,3-b]pyridin-3-yl)-guanidines, N-(1H-pyrrolo[2,3-b]pyridin-3-yl)-guanidines, and N-(1H-indol-3-yl)-guanidines. Bioorganic & medicinal chemistry 20070501
Differential protein expression in pancreatic islets after treatment with an imidazoline compound. Cellular and molecular life sciences : CMLS 20070501
Intramolecular 'hydroiminiumation and -amidiniumation' of alkenes: a convenient, flexible, and scalable route to cyclic iminium and imidazolinium salts. The Journal of organic chemistry 20070427
Theoretical assessment of naphazoline redoxchemistry and photochemistry. The journal of physical chemistry. B 20070419
Novel 1-oxyl-2-substitutedphenyl-4,4,5,5-tetramethylimidazolines: synthesis, selectively analgesic action, and QSAR analysis. Bioorganic & medicinal chemistry 20070415
Identification of IRAS/Nischarin as an I1-imidazoline receptor in PC12 rat pheochromocytoma cells. Journal of neurochemistry 20070401
Direct evidence for imidazoline (I1) receptor modulation of ethanol action on norepinephrine-containing neurons in the rostral ventrolateral medulla in conscious spontaneously hypertensive rats. Alcoholism, clinical and experimental research 20070401
Metabolic and antihypertensive effects of moxonidine and moxonidine plus irbesartan in patients with type 2 diabetes mellitus and mild hypertension: a sequential, randomized, double-blind clinical trial. Clinical therapeutics 20070401
Study of retention parameters obtained in RP-TLC system and their application on QSAR/QSPR of some alpha adrenergic and imidazoline receptor ligands. Journal of chromatographic science 20070301
Interactions of imidazoline ligands with the active site of purified monoamine oxidase A. The FEBS journal 20070301
Effect of agmatine on brain L-citrulline production during morphine withdrawal in rats: a microdialysis study in nucleus accumbens. Brain research 20070209
Reversible reduction of nitroxides to hydroxylamines: roles for ascorbate and glutathione. Free radical biology & medicine 20070201
Contribution of imidazoline receptors and alpha2-adrenoceptors in the rostral ventrolateral medulla to sympathetic baroreflex inhibition by systemic rilmenidine. Journal of hypertension 20070101
Distribution and cellular localization of imidazoleacetic acid-ribotide, an endogenous ligand at imidazol(in)e and adrenergic receptors, in rat brain. Journal of chemical neuroanatomy 20070101
Microwave assisted synthesis of triazoloquinazolinones and benzimidazoquinazolinones. Beilstein journal of organic chemistry 20070101
[Pharmacotherapeutical features of arterial hypertension in patients with diabetes mellitus]. Klinicheskaia meditsina 20070101
Drugs for the perioperative control of hypertension: current issues and future directions. Drugs 20070101
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Agmatine protects retinal ganglion cells from hypoxia-induced apoptosis in transformed rat retinal ganglion cell line. BMC neuroscience 20070101
Agmatine : metabolic pathway and spectrum of activity in brain. CNS drugs 20070101
Evidence for the tonic inhibition of spinal pain by nicotinic cholinergic transmission through primary afferents. Molecular pain 20070101
[Arterial hypertension in extreme situations]. Klinicheskaia meditsina 20070101
Characterization of an antiproliferative effect of imidazoline receptor ligands on PC12 cells. Pharmacological reports : PR 20070101
Characterization of copper(II) interactions with sinefungin, a nucleoside antibiotic: combined potentiometric, spectroscopic and DFT studies. Bioinorganic chemistry and applications 20070101
Focus on hypertension and overall cardiovascular risk: a report from the 21st scientific meeting of the International Society of Hypertension. Timely topics in medicine. Cardiovascular diseases 20070101
Involvement of I2-imidazoline binding sites in positive and negative morphine analgesia modulatory effects. European journal of pharmacology 20061228
Agmatine and a cannabinoid agonist, WIN 55212-2, interact to produce a hypothermic synergy. European journal of pharmacology 20061228
The imidazoline I2-site ligands BU 224 and 2-BFI inhibit MAO-A and MAO-B activities, hydrogen peroxide production, and lipolysis in rodent and human adipocytes. European journal of pharmacology 20061215
Lewis base activation of grignard reagents with N-heterocyclic carbenes. Cu-free catalytic enantioselective additions to gamma-chloro-alpha,beta-unsaturated esters. Journal of the American Chemical Society 20061213
Tricyclic imidazoline derivatives as potent and selective adenosine A1 receptor antagonists. Journal of medicinal chemistry 20061130
Asymmetric Baylis-Hillman reactions promoted by chiral imidazolines. Chemistry, an Asian journal 20061120
Design and synthesis of novel imidazoline derivatives with potent antihyperglycemic activity in a rat model of type 2 diabetes. Bioorganic & medicinal chemistry 20061115
Enhancement of MALDI-MS spectra of C-terminal peptides by the modification of proteins via an active ester generated in situ from an oxazolone. Analytical chemistry 20061115
Chiral N-heterocyclic carbene ligands based on a biisoquinoline template. Dalton transactions (Cambridge, England : 2003) 20061107
Hdmx modulates the outcome of p53 activation in human tumor cells. The Journal of biological chemistry 20061103
Modulation of agmatine on calcium signal in morphine-dependent CHO cells by activation of IRAS, a candidate for imidazoline I1 receptor. European journal of pharmacology 20061024
Rhes expression in pancreatic beta-cells is regulated by efaroxan in a calcium-dependent process. Biochemical and biophysical research communications 20061020
2-(4,5-Dihydroimidazol-2-yl)benzimidazoles as highly selective imidazoline I2/adrenergic alpha2 receptor ligands. Bioorganic & medicinal chemistry 20061001
Synthesis and pharmacological studies of new hybrid derivatives of fentanyl active at the mu-opioid receptor and I2-imidazoline binding sites. Bioorganic & medicinal chemistry 20061001
[Imidazoline I(2) receptors as a possible marker for malignancy in human glial cell tumours]. Revista de neurologia 20061001
N, N' (4,5-dihydro-1h-imidazol-2-yl)3-aza-1,10-decane-diamine and N, N'(4,5-dihydro-1H-imidazol-2-yl)3-aza-1, 10-dodecane-diamine antagonize cell proliferation as selective ligands towards topoisomerase II. The Journal of pharmacy and pharmacology 20061001
RX871024 reduces NO production but does not protect against pancreatic beta-cell death induced by proinflammatory cytokines. Biochemical and biophysical research communications 20060908
Discriminative stimulus properties of the selective and highly potent alpha2-adrenoceptor agonist, S18616, in rats: mediation by the alpha2A subtype, and blockade by the atypical antidepressants, mirtazapine and mianserin. Neuropharmacology 20060901
Hypochlorous acid induces apoptosis of cultured cortical neurons through activation of calpains and rupture of lysosomes. Journal of neurochemistry 20060901
Intramolecular 1,3-dipolar cycloadditions of dihydroimidazolium ylides: synthesis of pyrrolo[1,2,3-de]quinoxalines and imidazo[1,2-a]indoles. Organic & biomolecular chemistry 20060821
Involvement of phosphatidylcholine-selective phospholipase C in activation of mitogen-activated protein kinase pathways in imidazoline receptor antisera-selected protein. Journal of cellular biochemistry 20060815
Modular synthesis of heterocyclic carbene precursors. The Journal of organic chemistry 20060804
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Evidence against alpha-adrenoceptors mediating relaxation in rat thoracic aortae: alpha-agonists relaxation depends on interaction with alpha-adrenoceptors. Fundamental & clinical pharmacology 20060801
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Sensitization of cancer cells to DNA damaging agents by imidazolines. Journal of the American Chemical Society 20060719
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Efficacy and tolerability of rilmenidine compared with isradipine in hypertensive patients with features of metabolic syndrome. Current medical research and opinion 20060701
Unexpected behaviour of tosylated and acetylated imidazolinium salts. Organic & biomolecular chemistry 20060607
Synthesis of imidazoline and imidazo[2,1-c][1,2,4]triazole aryl derivatives containing the methylthio group as possible antibacterial agents. Bioorganic & medicinal chemistry 20060601
Agmatine is transported into liver mitochondria by a specific electrophoretic mechanism. The Biochemical journal 20060601
Is brimonidine ophthalmic a safe therapy for infants? Journal of clinical pharmacy and therapeutics 20060601
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Theoretical study of structure, pKa, lipophilicity, solubility, absorption, and polar surface area of some centrally acting antihypertensives. Bioorganic & medicinal chemistry 20060315
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[Comparison of the effectiveness of moxonidine and prestarium in postmenopausal women with mild and moderate arterial hypertension]. Klinicheskaia meditsina 20060101
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Imidazoline receptors in relaxation of acetylcholine-constricted isolated rat jejunum. Pharmacological reports : PR 20060101
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Monomeric G-protein, Rhes, is not an imidazoline-regulated protein in pancreatic beta-cells. Biochemical and biophysical research communications 20051223
Synthesis of 2,6-diphenylpyrazine derivatives and their DNA binding and cytotoxic properties. European journal of medicinal chemistry 20051201
Essential role of the imidazoline moiety in the insulinotropic effect but not the KATP channel-blocking effect of imidazolines; a comparison of the effects of efaroxan and its imidazole analogue, KU14R. Diabetologia 20051201
Identification of the central imidazoline receptor subtype involved in modulation of halothane-epinephrine arrhythmias in rats. Anesthesia and analgesia 20051201
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Opposite changes in imidazoline I2 receptors and alpha2-adrenoceptors density in rat frontal cortex after induced gliosis. Life sciences 20051126
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Bioisosteric phentolamine analogs as potent alpha-adrenergic antagonists. Bioorganic & medicinal chemistry letters 20051101
Central actions of agmatine in conscious spontaneously hypertensive rats. Clinical and experimental hypertension (New York, N.Y. : 1993) 20051101
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IRAS, a candidate for I1-imidazoline receptor, mediates inhibitory effect of agmatine on cellular morphine dependence. Biochemical pharmacology 20051001
Role of imidazoline receptors in the anti-aversive properties of clonidine during opiate withdrawal in rats. The European journal of neuroscience 20051001
Neuroprotection by alpha 2-adrenergic agonists in cerebral ischemia. Current neuropharmacology 20051001
Characterisation of imidazoline I2 binding sites in pig brain. European journal of pharmacology 20050905
Effect of BU98008, an imidazoline1-binding site ligand, on body temperature in mice. European journal of pharmacology 20050905
Regulation of p21-activated kinase-independent Rac1 signal transduction by nischarin. The Journal of biological chemistry 20050902
Mitogen-activated protein kinase phosphorylation in the rostral ventrolateral medulla plays a key role in imidazoline (i1)-receptor-mediated hypotension. The Journal of pharmacology and experimental therapeutics 20050901
Involvement of supraspinal imidazoline receptors and descending monoaminergic pathways in tizanidine-induced inhibition of rat spinal reflexes. Journal of pharmacological sciences 20050901
High-affinity binding of beta-carbolines to imidazoline I2B receptors and MAO-A in rat tissues: norharman blocks the effect of morphine withdrawal on DOPA/noradrenaline synthesis in the brain. European journal of pharmacology 20050822
Nitrosation chemistry of pyrroline, 2-imidazoline, and 2-oxazoline: theoretical Curtin-Hammett analysis of retro-ene and solvent-assisted C-X cleavage reactions of alpha-hydroxy-N-nitrosamines. The Journal of organic chemistry 20050819
Ultrasonic vocalization production of preweanling rats: effects of central and peripheral administration of alpha2-adrenoceptor agonists. European journal of pharmacology 20050711
Evidence for different pharmacological targets for imidazoline compounds inhibiting settlement of the barnacle Balanus improvisus. Journal of experimental zoology. Part A, Comparative experimental biology 20050701
Mechanisms involved in the antinociception caused by agmatine in mice. Neuropharmacology 20050601
Autoradiographic localisation of [3H]2-BFI imidazoline I2 binding sites in mouse brain. European journal of pharmacology 20050601
Inhibition by agmatine on morphine-induced conditioned place preference in rats. European journal of pharmacology 20050516
Site-dependent inhibition of neuronal c-jun in the brainstem elicited by imidazoline I1 receptor activation: role in rilmenidine-evoked hypotension. European journal of pharmacology 20050509
Urinary responses to acute moxonidine are inhibited by natriuretic peptide receptor antagonist. British journal of pharmacology 20050501
The role of alpha2-agonists in neurosurgery. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20050501
Enhancement of EFS-induced contractions, by agmatine, in guinea pig gallbladder smooth muscle strips. Journal of gastroenterology 20050501
Ortho-selective direct cross-coupling reaction of 2-aryloxazolines and 2-arylimidazolines with aryl and alkenyl halides catalyzed by ruthenium complexes. The Journal of organic chemistry 20050415
Interleukin (IL)-1beta toxicity to islet beta cells: Efaroxan exerts a complete protection. Journal of cellular physiology 20050401
Noradrenergic modulation of XII motoneuron inspiratory activity does not involve alpha2-receptor inhibition of the Ih current or presynaptic glutamate release. Journal of applied physiology (Bethesda, Md. : 1985) 20050401
Activation of imidazoline receptors in adrenal gland to lower plasma glucose in streptozotocin-induced diabetic rats. Diabetologia 20050401
The imidazoline-like drug S23515 affects lipid metabolism in hepatocyte by inhibiting the oxidosqualene: lanosterol cyclase activity. Biochemical pharmacology 20050401
Metabolic activation of a 1,3-disubstituted piperazine derivative: evidence for a novel ring contraction to an imidazoline. Chemical research in toxicology 20050201
Small molecule antagonists of the MDM2 oncoprotein as anticancer agents. Current cancer drug targets 20050201
Synthesis of 2,3,5,6-tetrahydro-3H-imidazo[2,1-b] [1,3,5]benzotriazepines and their oxidative ring contraction into 1-(4,5-dihydro-1H-imidazol-2-yl)-1H-benzimidazoles. Farmaco (Societa chimica italiana : 1989) 20050201
Imidazolinium salts as catalysts for the aza-Diels-Alder reaction. Organic & biomolecular chemistry 20050121
Rat clonidine mydriasis model: imidazoline receptors are not involved. Autonomic neuroscience : basic & clinical 20050115
Cardiovascular effects of agmatine within the rostral ventrolateral medulla are similar to those of clonidine in anesthetized rats. Experimental brain research 20050101
[The role of alpha2-adrenergic and I1-imidazoline receptors in the effects of clonidine and moxonidine on isolated large intestine of mice]. Eksperimental'naia i klinicheskaia farmakologiia 20050101
Imidazoline receptors associated with noradrenergic terminals in the rostral ventrolateral medulla mediate the hypotensive responses of moxonidine but not clonidine. Neuroscience 20050101
Comparison of rilmenidine and lisinopril on ambulatory blood pressure and plasma lipid and glucose levels in hypertensive women with metabolic syndrome. Current medical research and opinion 20050101
Preparation, structure and affinity for imidazoline I2 receptors and alpha2-adrenoceptors of 1-[(4,5-dihydroimidazolidin-2-yl)imino]indan-2-ols. Acta poloniae pharmaceutica 20050101
Harmane and harmalan are bioactive components of classical clonidine-displacing substance. Biochemistry 20041228
Human Nischarin/imidazoline receptor antisera-selected protein is targeted to the endosomes by a combined action of a PX domain and a coiled-coil region. The Journal of biological chemistry 20041224
Alumina supported potassium permanganate: an efficient reagent for chemoselective dehydrogenation of 2-imidazolines under mild conditions. Bioorganic & medicinal chemistry letters 20041220
Dose-independent antinociceptive interaction of endogenous ligands at the spinal level. Brain research 20041210
Locomotor effects of imidazoline I2-site-specific ligands and monoamine oxidase inhibitors in rats with a unilateral 6-hydroxydopamine lesion of the nigrostriatal pathway. British journal of pharmacology 20041201
Idazoxan effects upon contractile activity in the rat aorta are related to alpha adrenoceptors and L-type channels. Fundamental & clinical pharmacology 20041201
Glucose dependence of imidazoline-induced insulin secretion: different characteristics of two ATP-Sensitive K+ channel-blocking compounds. Diabetes 20041201
Rilmenidine prevents blood pressure increase in rats with compromised nitric oxide production. Acta pharmacologica Sinica 20041201
Anxious and depressive disorders and their comorbidity: effect on central nervous system noradrenergic function. Biological psychiatry 20041201
Sensitization of tumor cells toward chemotherapy: enhancing the efficacy of camptothecin with imidazolines. Chemistry & biology 20041201
1,3-Bis(N,N-dialkylamino)imidazolin-2-ylidenes: synthesis and reactivity of a new family of stable N-heterocyclic carbenes. Journal of the American Chemical Society 20041020
The putative imidazoline receptor agonist, harmane, promotes intracellular calcium mobilisation in pancreatic beta-cells. European journal of pharmacology 20041006
Clonidine and guanfacine-induced antinociception in visceral pain: possible role of alpha 2/I2 binding sites. European journal of pharmacology 20041006
Differential modulation by estrogen of alpha2-adrenergic and I1-imidazoline receptor-mediated hypotension in female rats. Journal of applied physiology (Bethesda, Md. : 1985) 20041001
Effects of centrally acting antihypertensive drugs on the microcirculation of spontaneously hypertensive rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20041001
Allosteric modulation of semicarbazide-sensitive amine oxidase activities in vitro by imidazoline receptor ligands. British journal of pharmacology 20041001
I1 imidazoline receptor-mediated effects on apoptotic processes in PC12 cells. Cell death and differentiation 20040901
Imidazoline binding sites and their ligands: an overview of the different chemical structures. Medicinal research reviews 20040901
Moxonidine in the treatment of overweight and obese patients with the metabolic syndrome: a postmarketing surveillance study. Journal of human hypertension 20040901
Spontaneous vesicle formation and phase behavior in mixtures of an anionic surfactant with imidazoline compounds. Langmuir : the ACS journal of surfaces and colloids 20040817
Insights into CO/styrene copolymerization by using Pd(II) catalysts containing modular pyridine-imidazoline ligands. Chemistry (Weinheim an der Bergstrasse, Germany) 20040806
Imidazoline receptors but not alpha 2-adrenoceptors are regulated in spontaneously hypertensive rat heart by chronic moxonidine treatment. The Journal of pharmacology and experimental therapeutics 20040801
Rilmenidine sympatholytic activity preserves mental stress, orthostatic sympathetic responses and adrenaline secretion. Journal of hypertension 20040801
Imidazoline receptors in the heart: a novel target and a novel mechanism of action that involves atrial natriuretic peptides. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20040801
Fluorescent GTP-sensing in aqueous solution of physiological pH. Journal of the American Chemical Society 20040728
Preparation of enantiopure biimidazoline ligands and their use in asymmetric catalysis. Organic & biomolecular chemistry 20040721
Augmentation of moxonidine-induced increase in ANP release by atrial hypertrophy. American journal of physiology. Heart and circulatory physiology 20040701
Course and therapy of intoxication with imidazoline derivate naphazoline. International journal of pediatric otorhinolaryngology 20040701
Chronic administration of 2-(2-benzofuranyl)-2-imidazoline (2-BFI) induces region-specific increases in [3H]2-BFI binding to rat central imidazoline I2 sites. Neuroscience letters 20040603
In vitro and in vivo measurement of pH and thiols by EPR-based techniques. Antioxidants & redox signaling 20040601
Integrin regulation of cell signalling and motility. Biochemical Society transactions 20040601
Effect of clonidine on cardiac norepinephrine spillover in isolated rat heart. Journal of cardiovascular pharmacology 20040601
Central blockade of nitric oxide synthesis reduces moxonidine-induced hypotension. British journal of pharmacology 20040601
LNP 906, the first high-affinity photoaffinity ligand selective for I1 imidazoline receptors. British journal of pharmacology 20040601
Moxonidine and rilmenidine injected into the medial septal area reduces the salivation induced by pilocarpine. Autonomic neuroscience : basic & clinical 20040531
Pharmacological characterisation of novel alpha 2-adrenoceptor antagonists as potential brain imaging agents. Neuropharmacology 20040501
Effect of i1 imidazoline receptor agonist, moxonidine, in nitric oxide-deficient hypertension in pregnant rats. Journal of cardiovascular pharmacology 20040501
Imidazoline I(2) receptor density increases with the malignancy of human gliomas. Journal of neurology, neurosurgery, and psychiatry 20040501
[The role of the central nervous system imidazoline receptors in cardiovascular manifestations of emotional stress]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20040501
Activation of imidazoline receptor by agmatine to lower plasma glucose in streptozotocin-induced diabetic rats. Neuroscience letters 20040325
Mechanism underlying blockade of voltage-gated calcium channels by agmatine in cultured rat hippocampal neurons. Acta pharmacologica Sinica 20040301
Selective imidazoline agonist moxonidine plus the ACE inhibitor ramipril in hypertensive patients with impaired insulin sensitivity: partners in a successful MARRIAGE? Current medical research and opinion 20040301
Imidazoline2 (I2) receptor- and alpha2-adrenoceptor-mediated modulation of hypothalamic-pituitary-adrenal axis activity in control and acute restraint stressed rats. Journal of psychopharmacology (Oxford, England) 20040301
Treatment of postmenopausal hypertension with moxonidine, a selective imidazoline receptor agonist. International journal of clinical practice. Supplement 20040301
[Centrally-acting antihypertensive drugs]. Nihon rinsho. Japanese journal of clinical medicine 20040301
Effect of moxonidine on contractile activity of isolated large intestine in mice: role of alpha2-adrenoceptors and Ii-imidazoline receptors. Bulletin of experimental biology and medicine 20040301
Synthesis, molecular structure and reactivity of 5-methylidene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolines. Molecules (Basel, Switzerland) 20040227
Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorganic & medicinal chemistry letters 20040223
Pyrazino[1,2-a]indoles as novel high-affinity and selective imidazoline I(2) receptor ligands. Bioorganic & medicinal chemistry letters 20040223
Chronic ethanol administration attenuates imidazoline I1 receptor- or alpha 2-adrenoceptor-mediated reductions in blood pressure and hemodynamic variability in hypertensive rats. European journal of pharmacology 20040206
Synthesis and biological evaluation of new cyclic amidine analogs of chlorambucil. Farmaco (Societa chimica italiana : 1989) 20040201
The effects of imidazoline agents on the aggregation of human platelets. The Journal of pharmacy and pharmacology 20040201
Fentanyl derivatives bearing aliphatic alkaneguanidinium moieties: a new series of hybrid molecules with significant binding affinity for mu-opioid receptors and I2-imidazoline binding sites. Bioorganic & medicinal chemistry letters 20040119
Binding of an imidazopyridoindole at imidazoline I2 receptors. Bioorganic & medicinal chemistry letters 20040119
Agmatine signaling: odds and threads. Cardiovascular drug reviews 20040101
Elevated sympathetic activity may promote insulin resistance syndrome by activating alpha-1 adrenergic receptors on adipocytes. Medical hypotheses 20040101
Efficacy and tolerability of long-term rilmenidine treatment in hypertensive diabetic patients. A retrospective analysis of a general practice study. American journal of cardiovascular drugs : drugs, devices, and other interventions 20040101
Effects of rilmenidine on proximal tubular fluid absorption in rats. Clinical and experimental pharmacology & physiology 20040101
[Effect of rilmenidine on intraocular pressure in rabbits, interaction with efaroxan and rauwolscine]. Klinika oczna 20040101
[Renal sequelae of sympathetic hyperactivity]. Wiener medizinische Wochenschrift (1946) 20040101
[Rilmenidine sympatholytic activity preserves mental and orthostatic sympathetic response and epinephrine secretion]. Archives des maladies du coeur et des vaisseaux 20040101
alpha2-Adrenoceptor agonists: shedding light on neuroprotection? British medical bulletin 20040101
The susceptibility of certain microbial strains to some imidazoline derivatives. Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina 20040101
Effects of the beta-carbolines, harmane and pinoline, on insulin secretion from isolated human islets of Langerhans. European journal of pharmacology 20031215
Contrasting metabolic effects of antihypertensive agents. The Journal of pharmacology and experimental therapeutics 20031201
Agmatine and Imidazolines: Their Novel Receptors and Enzymes. Proceedings of the 4th International Symposium on Agmatine and Imidazoline Systems. April 9-11, 2003, San Diego, California, USA. Annals of the New York Academy of Sciences 20031201
Relevance of imidazoline receptors and agmatine to psychiatry: a decade of progress. Annals of the New York Academy of Sciences 20031201
Effect of agmatine on acute and mononeuropathic pain. Annals of the New York Academy of Sciences 20031201
Spinal and supraspinal agmatine activate different receptors to enhance spinal morphine antinociception. Annals of the New York Academy of Sciences 20031201
Effect of agmatine on electrically and chemically induced seizures in mice. Annals of the New York Academy of Sciences 20031201
Endogenous imidazoline receptor ligands relax rat aorta by an endothelium-dependent mechanism. Annals of the New York Academy of Sciences 20031201
I(1) imidazoline receptors involved in cardiovascular regulation: where are we and where are we going? Annals of the New York Academy of Sciences 20031201
Are centrally acting imidazoline agents appropriate therapy for renovascular hypertension? Annals of the New York Academy of Sciences 20031201
Cardiac effects of moxonidine in spontaneously hypertensive obese rats. Annals of the New York Academy of Sciences 20031201
The role of I(1)-imidazoline receptors and alpha(2)-adrenergic receptors in the modulation of glucose and lipid metabolism in the SHROB model of metabolic syndrome X. Annals of the New York Academy of Sciences 20031201
Involvement of forebrain imidazoline and alpha(2)-adrenergic receptors in the antidipsogenic response to moxonidine. Annals of the New York Academy of Sciences 20031201
Moxonidine displays a presynaptic alpha-2-adrenoceptor-dependent synergistic sympathoinhibitory action at imidazoline-1 receptors. Annals of the New York Academy of Sciences 20031201
Norepinephrine release is reduced by I(1)-receptors in addition to alpha(2)-adrenoceptors. Annals of the New York Academy of Sciences 20031201
Normalization of up-regulated cardiac imidazoline I(1)-receptors and natriuretic peptides by chronic treatment with moxonidine in spontaneously hypertensive rats. Annals of the New York Academy of Sciences 20031201
Alpha(2A)-adrenergic versus imidazoline receptor controversy in rilmenidine's action: alpha(2A)-antagonism in humans versus alpha(2A)-agonism in rabbits. Annals of the New York Academy of Sciences 20031201
BU98008, a highly selective imidazoline(1)-receptor ligand. Annals of the New York Academy of Sciences 20031201
Apparent absence of direct renal effect of imidazoline receptor agonists. Annals of the New York Academy of Sciences 20031201
Atypical [(3)H]clonidine binding sites in human caudate and platelets on cryostat-cut sections. Annals of the New York Academy of Sciences 20031201
Novel ligands for the investigation of imidazoline receptors and their binding proteins. Annals of the New York Academy of Sciences 20031201
The effects of chronic administration of inhibitors of flavin and quinone amine oxidases on imidazoline I(1) receptor density in rat whole brain. Annals of the New York Academy of Sciences 20031201
In vivo effects of the I(2)-alkylating agent BU99006 on the immunodensity of imidazoline receptor proteins in the mouse brain. Annals of the New York Academy of Sciences 20031201
Restoration of first-phase insulin secretion by the imidazoline compound LY374284 in pancreatic islets of diabetic db/db mice. Annals of the New York Academy of Sciences 20031201
Effect of postmortem delay on imidazoline receptor-binding proteins in human and mouse brain. Annals of the New York Academy of Sciences 20031201
Association between I(2) binding sites and monoamine oxidase-B activity in platelets. Annals of the New York Academy of Sciences 20031201
Relationship between imidazoline(2) sites and monoamine oxidase. Annals of the New York Academy of Sciences 20031201
Initial evaluation of novel selective ligands for imidazoline(2) receptors in rat whole brain. Annals of the New York Academy of Sciences 20031201
Investigation of the affinities of two new beta-carbolines for rat brain imidazoline(2) receptors. Annals of the New York Academy of Sciences 20031201
Identification of an I(2) binding protein from rabbit brain. Annals of the New York Academy of Sciences 20031201
In vivo estimation of imidazoline(2) binding site turnover. Annals of the New York Academy of Sciences 20031201
Moxonidine, a mixed alpha(2)-adrenergic and imidazoline receptor agonist, identifies a novel adrenergic target for spinal analgesia. Annals of the New York Academy of Sciences 20031201
Evidence for nonadrenoceptor responses to imidazoline derivatives in the porcine isolated rectal artery. Annals of the New York Academy of Sciences 20031201
Cell signaling by imidazoline-1 receptor candidate, IRAS, and the nischarin homologue. Annals of the New York Academy of Sciences 20031201
IRAS is an anti-apoptotic protein. Annals of the New York Academy of Sciences 20031201
Assembly of PRR-containing receptors on scaffolds: a model for imidazoline I(1)-receptor action. Annals of the New York Academy of Sciences 20031201
IRAS splice variants. Annals of the New York Academy of Sciences 20031201
Intracellular effect of imidazoline receptor on alpha(2A)-noradrenergic receptor. Annals of the New York Academy of Sciences 20031201
Relationship between platelet imidazoline receptor-binding peptides and candidate imidazoline-1 receptor, IRAS. Annals of the New York Academy of Sciences 20031201
Imidazoline binding sites on receptors and enzymes: emerging targets for novel antidepressant drugs? Journal of psychiatry & neuroscience : JPN 20031101
Synthesis and antibacterial activity of 1 beta-methyl-2-(5-substituted imidazolino pyrrolidin-3-ylthio)carbapenem derivatives. Archiv der Pharmazie 20031101
Modulation by alpha-difluoromethyl-ornithine and aminoguanidine of pain threshold, morphine analgesia and tolerance. European journal of pharmacology 20031008
The imidazoline NNC77-0020 affects glucose-dependent insulin, glucagon and somatostatin secretion in mouse pancreatic islets. Naunyn-Schmiedeberg's archives of pharmacology 20031001
2-(4,5-dihydro-1H-imidazol-2-yl)indazole (indazim) derivatives as selective I(2) imidazoline receptor ligands. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20031001
Are one or two dangerous? Clonidine and topical imidazolines exposure in toddlers. The Journal of emergency medicine 20031001
Adverse mortality effect of central sympathetic inhibition with sustained-release moxonidine in patients with heart failure (MOXCON). European journal of heart failure 20031001
Efficacy and safety of rilmenidine, a selective imidazoline I1 receptor binding ligand, in mild-to-moderate Thai hypertensive patients. Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20031001
Effect of ethanol on reductions in norepinephrine electrochemical signal in the rostral ventrolateral medulla and hypotension elicited by I1-receptor activation in spontaneously hypertensive rats. Alcoholism, clinical and experimental research 20030901
Nischarin inhibits Rac induced migration and invasion of epithelial cells by affecting signaling cascades involving PAK. Experimental cell research 20030815
The role of I(1)-imidazoline and alpha(2)-adrenergic receptors in the modulation of glucose metabolism in the spontaneously hypertensive obese rat model of metabolic syndrome X. The Journal of pharmacology and experimental therapeutics 20030801
The effect of agmatine on the vascular reactivity in streptozotocin-diabetic rats. Pharmacological research 20030801
The I(1)-imidazoline receptor in PC12 pheochromocytoma cells reverses NGF-induced ERK activation and induces MKP-2 phosphatase. Brain research 20030801
IRAS, the human homologue of Nischarin, prolongs survival of transfected PC12 cells. Cell death and differentiation 20030801
Pediatric Visine (tetrahydrozoline) ingestion: case report and review of imidazoline toxicity. Veterinary and human toxicology 20030801
Constitutive precoupling to G(i) and increased agonist potency in the alpha(2B)-adrenoceptor. Biochemical and biophysical research communications 20030711
Conformation of a bound inhibitor of blood coagulant factor Xa. Biochemistry 20030708
Naphazoline intoxication in a child-a clinical and forensic toxicological case. Forensic science international 20030708
The neonicotinoid electronegative pharmacophore plays the crucial role in the high affinity and selectivity for the Drosophila nicotinic receptor: an anomaly for the nicotinoid cation--pi interaction model. Biochemistry 20030701
Role of I1-imidazoline receptors within the caudal ventrolateral medulla in cardiovascular responses to clonidine in rats. Journal of cardiovascular pharmacology 20030701
Pharmacological characterization of unique prazosin-binding sites in human kidney. Naunyn-Schmiedeberg's archives of pharmacology 20030701
Mechanisms underlying combined action of clonidine and local anesthetics. Bulletin of experimental biology and medicine 20030701
Dissimilar pharmacological responses by a new series of imidazoline derivatives at precoupled and ligand-activated alpha 2A-adrenoceptor states: evidence for effector pathway-dependent differential antagonism. The Journal of pharmacology and experimental therapeutics 20030601
Pharmacological characterization of the novel histamine H3-receptor antagonist N-(3,5-dichlorophenyl)-N'-[[4-(1H-imidazol-4-ylmethyl)phenyl]-methyl]-urea (SCH 79687). The Journal of pharmacology and experimental therapeutics 20030601
Prolonged activation of mesolimbic dopaminergic neurons by morphine withdrawal following clonidine: participation of imidazoline and norepinephrine receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030601
Synthesis of some 1-(2,4-dihydroxythiobenzoyl)imidazoles, -imidazolines and -tetrazoles and their potent activity against Candida species. Farmaco (Societa chimica italiana : 1989) 20030601
Tritium labelling and characterization of the potent imidazoline I1 receptor antagonist [5,7-3H] (+/-)-efaroxan at high specific activity. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20030601
Agmatine and imidazoline systems--fourth international symposium: 9-11 April 2003, San Diego, CA, USA. IDrugs : the investigational drugs journal 20030601
Eta6-mesityl,eta1-imidazolinylidene-carbene-ruthenium(II) complexes: catalytic activity of their allenylidene derivatives in alkene metathesis and cycloisomerisation reactions. Chemistry (Weinheim an der Bergstrasse, Germany) 20030523
Antidepressant-like effect of agmatine and its possible mechanism. European journal of pharmacology 20030523
Imidazoline binding sites (IBS) profile modulation: key role of the bridge in determining I1-IBS or I2-IBS selectivity within a series of 2-phenoxymethylimidazoline analogues. Journal of medicinal chemistry 20030522
Synthesis and biological evaluation of new 2-(4,5-dihydro-1H-imidazol-2-yl)-3,4-dihydro-2H-1,4-benzoxazine derivatives. Journal of medicinal chemistry 20030508
Behavioral, neuroendocrine and neurochemical effects of the imidazoline I2 receptor selective ligand BU224 in naive rats and rats exposed to the stress of the forced swim test. Psychopharmacology 20030501
Clorgyline-induced switch from locomotion to mouthing in sensitization to the dopamine D2/D3 agonist quinpirole in rats: role of sigma and imidazoline I2 receptors. Psychopharmacology 20030501
Effects of the imidazoline binding site ligands, idazoxan and efaroxan, on the viability of insulin-secreting BRIN-BD11 cells. JOP : Journal of the pancreas 20030501
Increased levels of advanced glycation end products in human cataractous lenses. Journal of cataract and refractive surgery 20030501
Potential serotonergic and noradrenergic involvement in the discriminative stimulus effects of the selective imidazoline I2-site ligand 2-BFI. Pharmacology, biochemistry, and behavior 20030501
Imidazoline NNC77-0074 stimulates Ca2+-evoked exocytosis in INS-1E cells by a phospholipase A2-dependent mechanism. Biochemical and biophysical research communications 20030418
Spinal antinociceptive effect of agmatine and tentative analysis of involved receptors: study in an electrophysiological model of rats. Brain research 20030411
Imidazoline NNC77-0074 stimulates insulin secretion and inhibits glucagon release by control of Ca(2+)-dependent exocytosis in pancreatic alpha- and beta-cells. European journal of pharmacology 20030411
Contribution of individual cytochrome P450 isozymes to the O-demethylation of the psychotropic beta-carboline alkaloids harmaline and harmine. The Journal of pharmacology and experimental therapeutics 20030401
Novel imidazoline compounds that inhibit Kir-mediated vasorelaxation in rat middle cerebral artery. Naunyn-Schmiedeberg's archives of pharmacology 20030401
Identification and characterization of the imidazoline I2b-binding sites in the hamster brown adipose tissue as a study model for imidazoline receptors. Archives of physiology and biochemistry 20030401
In situ generation of carbenes: a general and versatile platform for organocatalytic living polymerization. Journal of the American Chemical Society 20030312
Metabolism and disposition of the antihypertensive agent moxonidine in humans. Drug metabolism and disposition: the biological fate of chemicals 20030301
Molecular structure of the rabbit alpha2A-adrenoceptor: a contribution to the alpha2A-adrenoceptor versus I1 imidazoline receptor controversy. Naunyn-Schmiedeberg's archives of pharmacology 20030301
Dual effect of agmatine in the bisected rat vas deferens. The Journal of pharmacy and pharmacology 20030301
Arginine deprivation, growth inhibition and tumour cell death: 2. Enzymatic degradation of arginine in normal and malignant cell cultures. British journal of cancer 20030224
Non-adrenergic exploratory behavior induced by moxonidine at mildly hypotensive doses. Brain research 20030221
Contractile actions of imidazoline alpha-adrenoceptor agonists and effects of noncompetitive alpha1-adrenoceptor antagonists in human vas deferens. European journal of pharmacology 20030221
Imidazoline receptors in the human umbilical cord. European journal of obstetrics, gynecology, and reproductive biology 20030210
2-Phenylimidazo[2,1-i]purin-5-ones: structure-activity relationships and characterization of potent and selective inverse agonists at Human A3 adenosine receptors. Bioorganic & medicinal chemistry 20030206
Attenuation of acute and chronic effects of morphine by the imidazoline receptor ligand 2-(2-benzofuranyl)-2-imidazoline in rat locus coeruleus neurons. British journal of pharmacology 20030201
[Naphazoline intoxication: course and therapy]. Laryngo- rhino- otologie 20030201
Rilmenidine produces mydriasis in cats by stimulation of CNS alpha 2-adrenoceptors. Autonomic & autacoid pharmacology 20030201
Central alpha(2) adrenergic receptors and cholinergic-induced salivation in rats. Brain research bulletin 20030130
Involvement of I(1)-imidazoline receptors in baroreceptor reflex in the caudal ventrolateral medulla of rats. Brain research 20030117
Importance of imidazoline-preferring receptors in the cardiovascular actions of chronically administered moxonidine, rilmenidine and clonidine in conscious rabbits. Journal of hypertension 20030101
Differential expression of alpha2-adrenoceptor vs. imidazoline binding sites in postmortem orbitofrontal cortex and amygdala of depressed subjects. Journal of psychiatric research 20030101
The detection and biotransformation of guanabenz in horses: a preliminary report. Veterinary therapeutics : research in applied veterinary medicine 20030101
[Agmatine--an endogenous ligand of imidazoline receptors]. Eksperimental'naia i klinicheskaia farmakologiia 20030101
[Effect of imidazoline receptor agonist moxonidine on the state of microcirculation and renal function in patients with hypertension and diabetes mellitus type 2]. Kardiologiia 20030101
[Acute exposure to imidazoline derivatives in children]. Jornal de pediatria 20030101
[Effect of Rilmenidine(Tenaxum) on the activity of the autonomic nervous system in patients with hypertension and asthma]. Wiadomosci lekarskie (Warsaw, Poland : 1960) 20030101
Synthesis and application of chiral phosphino-imidazoline ligands: Ir-catalyzed enantioselective hydrogenation. Organic letters 20021226
Plasma catecholamines and chronic congestive heart failure. Circulation 20021217
Agmatine inhibits arginine vasopressin-stimulated urea transport in the rat inner medullary collecting duct. Kidney international 20021201
Presynaptic effects of moxonidine in isolated buffer perfused rat hearts: role of imidazoline-1 receptors and alpha2-adrenoceptors. The Journal of pharmacology and experimental therapeutics 20021201
2-Hydroxy-3-(4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-5-ium-4-yl)benzoate monohydrate. Acta crystallographica. Section C, Crystal structure communications 20021201
Nitric oxide discriminates the sites and mechanisms of action of centrally acting anti-hypertensive drugs in rabbits. Neuropharmacology 20021201
Derivatization of (+/-)-5-[(2-methylphenoxy)methyl]-2-amino-2-oxazoline, an imidazoline binding sites ligand, with (+)-(R)-alpha-methylbenzyl isocyanate for drug monitoring purposes. Journal of enzyme inhibition and medicinal chemistry 20021201
Organocatalytic asymmetric conjugate addition of nitroalkanes to alpha,beta-unsaturated enones using novel imidazoline catalysts. The Journal of organic chemistry 20021129
Central serotonergic and adrenergic/imidazoline inhibitory mechanisms on sodium and water intake. Brain research 20021122
Protective effects of rilmenidine and AGN 192403 on oxidative cytotoxicity and mitochondrial inhibitor-induced cytotoxicity in astrocytes. Free radical biology & medicine 20021115
Effects of the imidazoline ligands efaroxan and KU14R on blood glucose homeostasis in the mouse. European journal of pharmacology 20021101
Clonidine displacement from type 1 imidazoline receptor by p-aminobenzamidine, the prototype of trypsin-like serine protease inhibitors. IUBMB life 20021101
Pharmacological evidence of a role for prejunctional imidazoline (I(1)) receptors in ocular function. Current eye research 20021101
Homoazanicotine: a structure-affinity study for nicotinic acetylcholine (nACh) receptor binding. Journal of medicinal chemistry 20021010
Inhibition of voltage-gated Ca2+ channels by antazoline. Neuroreport 20021007
The hypotensive action of rilmenidine is dependent on functional N-methyl-D-aspartate receptor in the rostral ventrolateral medulla of conscious spontaneously hypertensive rats. The Journal of pharmacology and experimental therapeutics 20021001
Pertussis toxin converts hyperpolarizations caused by alpha(2)-adrenoceptor agonists containing an imidazoline moiety into depolarizations in MIN 6 cells. Naunyn-Schmiedeberg's archives of pharmacology 20020901
Chronic imidazoline receptor activation in spontaneously hypertensive rats. American journal of hypertension 20020901
Agmatine facilitates memory of an inhibitory avoidance task in adult rats. Neurobiology of learning and memory 20020901
An imidazoline compound completely counteracts interleukin-1[beta] toxic effects to rat pancreatic islet [beta] cells. Molecular medicine (Cambridge, Mass.) 20020901
Distribution of [(3)H]BU224, a selective imidazoline I(2) binding site ligand, in rat brain. European journal of pharmacology 20020816
Inhibition of nucleoside transport by p38 MAPK inhibitors. The Journal of biological chemistry 20020809
(4R,5S)/(4S,5R)-4,5-Bis(4-hydroxyphenyl)-2-imidazolines: ligands for the estrogen receptor with a novel binding mode. Journal of medicinal chemistry 20020801
Evidence that the novel imidazoline compound FT005 is an alpha(2)-adrenoceptor agonist. British journal of pharmacology 20020801
[Efficacy and tolerance of rilmenidine in patients with mild to moderate hypertension. Results of a Czech and Slovak 6-month multicenter study]. Vnitrni lekarstvi 20020801
[125I]2-(2-chloro-4-iodo-phenylamino)-5-methyl-pyrroline (LNP 911), a high-affinity radioligand selective for I1 imidazoline receptors. Molecular pharmacology 20020701
Determination of tizanidine in human plasma by gas chromatography-mass spectrometry. The Analyst 20020701
[Conformational study of drugs which affect I1-imidazoline receptors]. Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti 20020701
5-Isothiocyanato-2-benzofuranyl-2-imidazoline (BU99006) an irreversible imidazoline(2) binding site ligand: in vitro and in vivo characterisation in rat brain. Neuropharmacology 20020701
A new, facile synthesis of 1,4,7,10-tetraazacyclododecane: cyclen. The Journal of organic chemistry 20020614
Involvement of imidazoline receptors in the centrally acting muscle-relaxant effects of tizanidine. European journal of pharmacology 20020612
Imidazoline receptors in the heart: characterization, distribution, and regulation. Journal of cardiovascular pharmacology 20020601
Desensitization of insulin secretion. Biochemical pharmacology 20020601
Remarkable substituent effects on antimicrobial activities of 1,3-diorganylimidazolidinium salts. Journal of chemotherapy (Florence, Italy) 20020601
Characterization of [(3)H]idazoxan binding sites on human platelets. Platelets 20020601
Insulin receptor substrate 4 associates with the protein IRAS. The Journal of biological chemistry 20020531
Distribution of furamidine analogues in tumor cells: influence of the number of positive charges. Journal of medicinal chemistry 20020509
I(2)-imidazoline binding site affinity of a structurally different type of ligands. Bioorganic & medicinal chemistry 20020501
Identification of the monomeric G-protein, Rhes, as an efaroxan-regulated protein in the pancreatic beta-cell. British journal of pharmacology 20020501
Novel AT(1) receptor-independent functions of losartan. Circulation research 20020419
Effects of sustained-release moxonidine, an imidazoline agonist, on plasma norepinephrine in patients with chronic heart failure. Circulation 20020416
Influence of compound structure on affinity, sequence selectivity, and mode of binding to DNA for unfused aromatic dications related to furamidine. Biopolymers 20020415
Guanidinium and aminoimidazolinium derivatives of N-(4-piperidyl)propanamides as potential ligands for mu opioid and I2-imidazoline receptors: synthesis and pharmacological screening. Bioorganic & medicinal chemistry 20020401
Imidazoline drugs stabilize lysosomes and inhibit oxidative cytotoxicity in astrocytes. Free radical biology & medicine 20020301
Effect of agmatine on locus coeruleus neuron activity: possible involvement of nitric oxide. British journal of pharmacology 20020301
Characterization of the discriminable stimulus produced by 2-BFI: effects of imidazoline I(2)-site ligands, MAOIs, beta-carbolines, agmatine and ibogaine. British journal of pharmacology 20020301
Sympatholytic therapy in primary hypertension: a user friendly role for the future. Journal of human hypertension 20020301
Oral toxicity of topical preparations. The Veterinary clinics of North America. Small animal practice 20020301
[Cardiovascular responses to emotional stress during activation of the brain imidazoline receptors]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20020301
Down-regulation of platelet imidazoline-1-binding sites after bupropion treatment. The international journal of neuropsychopharmacology 20020301
Noradrenaline release-inhibiting receptors on PC12 cells devoid of alpha(2(-)) and CB(1) receptors: similarities to presynaptic imidazoline and edg receptors. Neurochemistry international 20020201
Agmatine, an endogenous ligand at imidazoline binding sites, does not antagonize the clonidine-mediated blood pressure reaction. British journal of pharmacology 20020201
Agmatine oxidation by copper amine oxidase. European journal of biochemistry 20020201
Agmatine: a mastoparan-like activity related to direct activation of heterotrimeric G proteins. European journal of pharmacology 20020118
Alpha2-adrenoreceptors profile modulation and high antinociceptive activity of (S)-(-)-2-[1-(biphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazole. Journal of medicinal chemistry 20020103
Insulinotropic activity of the imidazoline derivative RX871024 in the diabetic GK rat. American journal of physiology. Endocrinology and metabolism 20020101
Imidazoline antihypertensive drugs: a critical review on their mechanism of action. Pharmacology & therapeutics 20020101
Liquid chromatography/electrospray ionisation mass spectrometric investigations of imidazoline corrosion inhibitors in crude oils. Rapid communications in mass spectrometry : RCM 20020101
An MCASE approach to the search of a cure for Parkinson's Disease. BMC pharmacology 20020101
Effects of central sympathetic inhibition on heart rate variability during steady-state exercise in healthy humans. Clinical physiology and functional imaging 20020101
Decongestant activity of a new formulation of xylometazoline nasal spray: a double-blind, randomized versus placebo and reference drugs controlled, dose-effect study. Drugs under experimental and clinical research 20020101
RX 821002 as a tool for physiological investigation of alpha(2)-adrenoceptors. CNS drug reviews 20020101
Role of alpha 2-adrenoceptors and imidazoline receptors in the A5 region in the regulation of renal function in the rat. Proceedings of the Western Pharmacology Society 20020101
[Clinical assessment of prolonged therapy of patients with hypertension and diabetes with imidazoline receptor agonist moxonidine]. Kardiologiia 20020101
Desensitization of insulin secretory response to imidazolines, tolbutamide, and quinine. I. Secretory and morphological studies. Biochemical pharmacology 20011215
The I1-imidazoline receptor in PC12 pheochromocytoma cells activates protein kinases C, extracellular signal-regulated kinase (ERK) and c-jun N-terminal kinase (JNK). Journal of neurochemistry 20011201
Site of action of moxonidine in the rat nephron. Naunyn-Schmiedeberg's archives of pharmacology 20011201
[Effect of the imidazoline receptor agonist moxonidine on hemodynamics, coronary circulation, metabolic ischemia markers and the neurohumoral system in patients with essential hypertension. Effects of moxonidine on coronary circulation]. Zeitschrift fur Kardiologie 20011201
Differential responses of regional vascular beds to local injection of agmatine in rats. Sheng li xue bao : [Acta physiologica Sinica] 20011201
Sympathetic nervous system and insulin resistance: from obesity to diabetes. American journal of hypertension 20011101
Antihypertensive treatment of patients with diabetes and hypertension. American journal of hypertension 20011101
I1 receptors, cardiovascular function, and metabolism. American journal of hypertension 20011101
Update on rilmenidine: clinical benefits. American journal of hypertension 20011101
Region-dependent effects of acute and chronic tranylcypromine in vivo on [3H]2-BFI binding to brain imidazoline I(2) sites. European journal of pharmacology 20011005
beta-carboline binding to imidazoline receptors. Drug and alcohol dependence 20011001
Localization of agmatine in vasopressin and oxytocin neurons of the rat hypothalamic paraventricular and supraoptic nuclei. Experimental neurology 20011001
Agmatine induces apoptosis in rat hepatocyte cultures. Journal of hepatology 20011001
Inhibition by clonidine of the carbachol-induced tension development and nonselective cationic current in guinea pig ileal myocytes. Japanese journal of pharmacology 20011001
Hemodynamic effects of agmatine in Dahl salt-sensitive hypertensive and Dahl salt-resistant rats. Sheng li xue bao : [Acta physiologica Sinica] 20011001
Imidazoline binding sites in the endocrine pancreas: can they fulfil their potential as targets for the development of new insulin secretagogues? Current pharmaceutical design 20010901
An attempt at cloning I1 imidazoline receptors. Journal of cardiovascular pharmacology 20010901
Evidence for the involvement of central I1 imidazoline receptor in ethanol counteraction of clonidine hypotension in spontaneously hypertensive rats. Journal of cardiovascular pharmacology 20010901
Effects of central imidazolinergic and alpha2-adrenergic activation on water intake. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20010901
Carbon disulfide promoted reactions of 2-chloro-4,5-dihydro-imidazole with some N-nucleophiles. Chemical & pharmaceutical bulletin 20010901
Effects of imidazoline antihypertensive drugs on sympathetic tone and noradrenaline release in the prefrontal cortex. British journal of pharmacology 20010901
Involvement of imidazoline receptors in the baroreflex effects of rilmenidine in conscious rabbits. Journal of hypertension 20010901
Moxonidine reduces pilocarpine-induced salivation in rats. Autonomic neuroscience : basic & clinical 20010813
Stimulatory effect of harmane and other beta-carbolines on locus coeruleus neurons in anaesthetized rats. Neuroscience letters 20010810
Novel dications with unfused aromatic systems: trithiophene and trifuran derivatives of furimidazoline. Chembiochem : a European journal of chemical biology 20010803
Safety and efficacy of moxonidine in mild to moderate hypertension. The Journal of the Association of Physicians of India 20010801
Imidazolinium salts as catalysts for the ring-opening alkylation of meso epoxides by alkylaluminum complexes. Organic letters 20010712
Phe-308 and Phe-312 in transmembrane domain 7 are major sites of alpha 1-adrenergic receptor antagonist binding. Imidazoline agonists bind like antagonists. The Journal of biological chemistry 20010706
Differential [(3)H]idazoxan and [(3)H]2-(2-benzofuranyl)-2-imidazoline (2-BFI) binding to imidazoline I(2) receptors in human postmortem frontal cortex. European journal of pharmacology 20010706
Synthesis of beta-D-galactofuranosyl nucleoside analogues. A new type of beta-D-galactofuranosidase inhibitor. Carbohydrate research 20010703
Biological significance of agmatine, an endogenous ligand at imidazoline binding sites. British journal of pharmacology 20010701
Glucose-induced insulin secretion is potentiated by a new imidazoline compound. Naunyn-Schmiedeberg's archives of pharmacology 20010701
Down-regulation of MAO-B activity and imidazoline receptors in rat brain following chronic treatment of morphine. Acta pharmacologica Sinica 20010701
The imidazoline RX871024 stimulates insulin secretion in pancreatic beta-cells from mice deficient in K(ATP) channel function. Biochemical and biophysical research communications 20010622
Topically applied clonidine protects the rat retina from ischaemia/reperfusion by stimulating alpha(2)-adrenoceptors and not by an action on imidazoline receptors. Brain research 20010615
Investigations of new lead structures for the design of selective estrogen receptor modulators. Journal of medicinal chemistry 20010607
Differential effects of alpha-adrenoceptor agonists on human retinal microvessel diameter. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20010601
Modulation of ACh-induced currents in rat adrenal chromaffin cells by ligands of alpha2 adrenergic and imidazoline receptors. Autonomic neuroscience : basic & clinical 20010514
Synthesis and biological evaluation of pyrrolinic isosteres of rilmenidine. Discovery of cis-/trans-dicyclopropylmethyl-(4,5-dimethyl-4,5-dihydro-3H-pyrrol-2-yl)-amine (LNP 509), an I1 imidazoline receptor selective ligand with hypotensive activity. Journal of medicinal chemistry 20010510
Nitronyl and imino nitroxides: improvement of Ullman's procedure and report on a new efficient synthetic route. Chemistry (Weinheim an der Bergstrasse, Germany) 20010504
Concentration-effect relationships of two infusion rates of the imidazoline antihypertensive agent rilmenidine for blood pressure and development of side-effects in healthy subjects. British journal of clinical pharmacology 20010501
Central imidazoline (I(1)) receptors modulate aqueous hydrodynamics. Current eye research 20010501
Blockade by agmatine of catecholamine release from chromaffin cells is unrelated to imidazoline receptors. European journal of pharmacology 20010406
Evidence for a non-adrenoceptor, imidazoline-mediated contractile response to oxymetazoline in the porcine isolated rectal artery. British journal of pharmacology 20010401
The novel imidazoline compound BL11282 potentiates glucose-induced insulin secretion in pancreatic beta-cells in the absence of modulation of K(ATP) channel activity. Diabetes 20010401
Evidence for functional presynaptic alpha-2 adrenoceptors and their down-regulation in human heart failure. Journal of the American College of Cardiology 20010401
[Action of agmatine on tension of isolated aortic artery and its receptor mechanism in rats]. Sheng li xue bao : [Acta physiologica Sinica] 20010401
[Agmatine inhibits the afferent activity of carotid baroreceptor in rats]. Sheng li xue bao : [Acta physiologica Sinica] 20010401
Role of I(1)-imidazoline receptors and alpha2-adrenoceptors in hemodynamic effects of moxonidine administration into the rostroventrolateral medulla. Bulletin of experimental biology and medicine 20010401
[Comparison of the antihypertensive efficacy of and tolerance to 2 imidazoline receptor agonists: moxonidine and rilmenidine in monotherapy]. Annales de cardiologie et d'angeiologie 20010401
The imidazoline receptor ligand 2-(2-benzofuranyl)-2-imidazoline is a dopamine-releasing agent in the rat striatum in vivo. Neuroscience letters 20010323
Inverse agonist activity at the alpha(2A)-adrenergic receptor. Molecular pharmacology 20010301
Naphazoline-induced suppression of aqueous humor pressure and flow: involvement of central and peripheral alpha(2)/I(1) receptors. Experimental eye research 20010301
Presence and functional significance of neuropeptide and neurotransmitter receptors in subcommissural organ cells. Microscopy research and technique 20010301
Relative importance of rostral ventrolateral medulla in sympathoinhibitory action of rilmenidine in conscious and anesthetized rabbits. Journal of cardiovascular pharmacology 20010301
Imidazoline I(1) receptor-induced activation of phosphatidylcholine-specific phospholipase C elicits mitogen-activated protein kinase phosphorylation in PC12 cells. European journal of pharmacology 20010301
Selective imidazoline I2 ligands do not show antidepressant-like activity in the forced swim test in mice. Journal of psychopharmacology (Oxford, England) 20010301
Synthesis and pharmacological evaluation of imidazoline sites I1 and I2 selective ligands. Bioorganic & medicinal chemistry 20010301
Imidazoline-modified benzylimidazolines as h5-HT(1D/1B) serotonergic ligands. Bioorganic & medicinal chemistry 20010301
Agmatine inhibits carotid sinus baroreflex in anesthetized rats. Acta pharmacologica Sinica 20010301
Influence of rostral ventrolateral medulla on renal sympathetic baroreflex in conscious rabbits. American journal of physiology. Regulatory, integrative and comparative physiology 20010201
Nitric oxide and central antihypertensive drugs: one more difference between catecholamines and imidazolines. Hypertension (Dallas, Tex. : 1979) 20010201
Characterization of a KATP channel-independent pathway involved in potentiation of insulin secretion by efaroxan. Diabetes 20010201
Imidazoline compounds protect against interleukin 1beta-induced beta-cell apoptosis. Diabetes 20010201
Interactions of ligands at angiotensin II-receptors and imidazoline receptors. Japanese journal of pharmacology 20010201
Moxonidine: some controversy. Expert opinion on pharmacotherapy 20010201
Phentolamine inhibits exocytosis of glucagon by Gi2 protein-dependent activation of calcineurin in rat pancreatic alpha -cells. The Journal of biological chemistry 20010112
Agmatine enhances the NADPH oxidase activity of neuronal NO synthase and leads to oxidative inactivation of the enzyme. Molecular pharmacology 20010101
[ACE-dependent and sympathetic components of blood pressure regulation in patients with essential hypertension]. Voprosy meditsinskoi khimii 20010101
A novel multifunctional labeling reagent for enhanced protein characterization with mass spectrometry. Rapid communications in mass spectrometry : RCM 20010101
Effect of ondansetron on the contractile responses to positive inotropic agents in electrically driven left atria of rats. Journal of basic and clinical physiology and pharmacology 20010101
[Imidazoline receptors-normal and pathological factors]. Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20010101
Centrally acting imidazoline I1-receptor agonists: do they have a place in the management of hypertension? American journal of cardiovascular drugs : drugs, devices, and other interventions 20010101

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