200,000+ products from a single source!
sales@angenechem.com
504-73-4 | 4,5-Dihydroisoxazole
CAS No: 504-73-4 Catalog No: AG00DUDC MDL No:
Product Description
Catalog Number:
AG00DUDC
Chemical Name:
4,5-Dihydroisoxazole
CAS Number:
504-73-4
IUPAC Name:
4,5-dihydro-1,2-oxazole
InChI:
InChI=1S/C3H5NO/c1-2-4-5-3-1/h2H,1,3H2
InChI Key:
WEQPBCSPRXFQQS-UHFFFAOYSA-N
Properties
Complexity:
50.9
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
71.037g/mol
Formal Charge:
0
Heavy Atom Count:
5
Hydrogen Bond Acceptor Count:
2
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
71.079g/mol
Monoisotopic Mass:
71.037g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
21.6A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-0.2
Literature
| Title | Journal |
|---|---|
| Synthesis and biological activities of novel isoxazoline-linked pseudodisaccharide derivatives. | Carbohydrate research 20120401 |
| Efficient synthesis of C2v-symmetrical pentakisadducts of C60 as versatile building blocks for fullerene architectures that involve a mixed octahedral addition pattern. | Chemistry (Weinheim an der Bergstrasse, Germany) 20120312 |
| (2E)-1-(3,4-Dichloro-phen-yl)-3-(2-hy-droxy-phen-yl)prop-2-en-1-one. | Acta crystallographica. Section E, Structure reports online 20120201 |
| (1E,4E)-1-(3-Nitro-phen-yl)-5-phenyl-penta-1,4-dien-3-one. | Acta crystallographica. Section E, Structure reports online 20120101 |
| Synthesis of highly functionalized β-aminocyclopentanecarboxylate stereoisomers by reductive ring opening reaction of isoxazolines. | Beilstein journal of organic chemistry 20120101 |
| Synthesis of Some New Isoxazoline Derivatives of Chalconised Indoline 2-one as a Potential Analgesic, Antibacterial and Anthelmimtic Agents. | Journal of young pharmacists : JYP 20120101 |
| The chemoselective reduction of isoxazoline γ-lactams through iminium Aza-Diels-Alder reactions: a short-cut synthesis of aminols as valuable intermediates towards nucleoside derivatives. | TheScientificWorldJournal 20120101 |
| Synthesis and bio-evaluation of human macrophage migration inhibitory factor inhibitor to develop anti-inflammatory agent. | Bioorganic & medicinal chemistry 20111215 |
| New spirocyclic Δ²-isoxazoline derivatives related to selective agonists of α7 neuronal nicotinic acetylcholine receptors. | European journal of medicinal chemistry 20111201 |
| (E)-1-(4,4''-Difluoro-5'-meth-oxy-1,1':3',1''-terphenyl-4'-yl)-3-(6-meth-oxy-naphthalen-2-yl)prop-2-en-1-one. | Acta crystallographica. Section E, Structure reports online 20111201 |
| (2RS,4'RS)-3'-(3-Chloro-4-meth-oxy-phen-yl)-4'-phenyl-4'H-spiro-[indene-2,5'-isoxazol]-1(3H)-one ethanol monosolvate. | Acta crystallographica. Section E, Structure reports online 20110901 |
| 3,5-Bis(4-meth-oxy-phen-yl)-4,5-dihydro-isoxazole. | Acta crystallographica. Section E, Structure reports online 20110801 |
| 1-Methyl-3-p-tolyl-3,3a,4,9b-tetra-hydro-1H-chromeno[4,3-c]isoxazole-3a-carbonitrile. | Acta crystallographica. Section E, Structure reports online 20110701 |
| 3'-(4-Meth-oxy-phen-yl)-4'-phenyl-3H,4'H-spiro-[1-benzothio-phene-2,5'-isoxazol]-3-one. | Acta crystallographica. Section E, Structure reports online 20110701 |
| 4-tert-Butyl-3',4'-bis-(4-methyl-phen-yl)-3,4-dihydro-1H,4'H-spiro-[naphthalene-2,5'-[1,2]oxazol]-1-one. | Acta crystallographica. Section E, Structure reports online 20110701 |
| Design, synthesis, and insecticidal evaluation of new benzoylureas containing isoxazoline and isoxazole group. | Journal of agricultural and food chemistry 20110511 |
| Preclinical discovery of apixaban, a direct and orally bioavailable factor Xa inhibitor. | Journal of thrombosis and thrombolysis 20110501 |
| (S)-[5-Methyl-3-(3-methyl-thio-phen-2-yl)-4,5-dihydro-isoxazol-5-yl]methanol. | Acta crystallographica. Section E, Structure reports online 20110501 |
| rac-(3S,4S)-3-Hy-droxy-4-phenyl-1-[(S)-(3-phenyl-4,5-dihydro-1,2-oxazol-5-yl)meth-yl]-4,5-dihydro-1H-1,5-benzo-diazepin-2(3H)-one. | Acta crystallographica. Section E, Structure reports online 20110401 |
| 3-{[3-(4-Chloro-phen-yl)-4,5-dihydro-1,2-oxazol-5-yl]meth-yl}-1,5-dimethyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione. | Acta crystallographica. Section E, Structure reports online 20110301 |
| cis-6-Bromo-4-(1-methyl-1H-indol-3-yl)-10,10a-dihydro-1H,4H-2,9-dioxa-3-aza-benz[f]azulene. | Acta crystallographica. Section E, Structure reports online 20110201 |
| The chemical synthesis of tetrodoxin: an ongoing quest. | Marine drugs 20110101 |
| Brominated compounds from marine sponges of the genus Aplysina and a compilation of their 13C NMR spectral data. | Marine drugs 20110101 |
| Readily accessible bicyclononynes for bioorthogonal labeling and three-dimensional imaging of living cells. | Angewandte Chemie (International ed. in English) 20101203 |
| Expanding stereochemical and skeletal diversity using petasis reactions and 1,3-dipolar cycloadditions. | Organic letters 20101119 |
| Synthesis and molluscicidal evaluation of some new pyrazole, isoxazole, pyridine, pyrimidine, 1,4-thiazine and 1,3,4-thiadiazine derivatives incorporating benzofuran moiety. | European journal of medicinal chemistry 20101101 |
| 1,5-Dimethyl-3-[(3-phenyl-4,5-dihydro-1,2-oxazol-5-yl)meth-yl]-1H-1,5-benzodiazepine-2,4(3H,5H)-dione. | Acta crystallographica. Section E, Structure reports online 20101101 |
| 4-tert-Butyl-4'-(4-meth-oxy-phen-yl)-3'-(4-methyl-phen-yl)-1,2,3,4-tetra-hydro-spiro-[naphthalene-2,5'(4'H)-1,2-oxazol]-1-one. | Acta crystallographica. Section E, Structure reports online 20101101 |
| Synthesis of 2-isoxazolines: enantioselective and racemic methods based on conjugate additions of oximes. | Chemistry (Weinheim an der Bergstrasse, Germany) 20101004 |
| Protein modification by strain-promoted alkyne-nitrone cycloaddition. | Angewandte Chemie (International ed. in English) 20100412 |
| Synthesis of the spiroiminal moiety of marineosins A and B. | Organic letters 20100402 |
| The antiparasitic isoxazoline A1443 is a potent blocker of insect ligand-gated chloride channels. | Biochemical and biophysical research communications 20100101 |
| ESI FTICR-MS analysis of larvae from the marine sponge Luffariella variabilis. | Marine drugs 20100101 |
| 1'-Benzyl-4,4''-bis-(4-chloro-phen-yl)-3-(2,6-dichloro-phen-yl)-1''-methyl-4,5-dihydro-isoxazole-5-spiro-3'-piperidine-5'-spiro-3''-pyrrolidine-2''-spiro-3'''-indoline-2''',4'-dione. | Acta crystallographica. Section E, Structure reports online 20100101 |
| Enantioselective intramolecular oxidative aminocarbonylation of alkenylureas catalyzed by palladium-spiro bis(isoxazoline) complexes. | The Journal of organic chemistry 20091218 |
| Towards commercial production of sponge medicines. | Marine drugs 20091201 |
| 6-Benzyl-3-(1,4-dioxaspiro-[4.5]decan-2-yl)-8,8-dimethyl-1-oxa-2,6-diaza-spiro-[4.4]non-2-ene-7,9-dione. | Acta crystallographica. Section E, Structure reports online 20091101 |
| Discovery of a novel class of isoxazoline voltage gated sodium channel blockers. | Bioorganic & medicinal chemistry letters 20090915 |
| Dimethyl trans-3-(4-bromo-phen-yl)-2-methyl-isoxazolidine-4,5-dicarboxyl-ate. | Acta crystallographica. Section E, Structure reports online 20090901 |
| Solution-phase parallel synthesis of novel spirooxazolinoisoxazolines. | Journal of combinatorial chemistry 20090309 |
| Synthesis, optimization and structure-activity relationships of 3,5-disubstituted isoxazolines as new anti-tuberculosis agents. | European journal of medicinal chemistry 20090201 |
| Synthesis of some new isoxazoline derivatives as possible anti-Candida agents. | Acta poloniae pharmaceutica 20090101 |
| Structural basis and catalytic mechanism for the dual functional endo-beta-N-acetylglucosaminidase A. | PloS one 20090101 |
| Macrophage migration inhibitory factor (MIF) tautomerase inhibitors as potential novel anti-inflammatory agents: current developments. | Current medicinal chemistry 20090101 |
| Double-blind, placebo-controlled, multiple-ascending-dose study on the pharmacodynamics of ABIO-08/01, a new CNS drug with potential anxiolytic activity. 2. EEG-tomography findings based on LORETA (low-resolution brain electromagnetic tomography). | Neuropsychobiology 20090101 |
| Synthesis of pluraflavin A 'aglycone'. | Journal of the American Chemical Society 20081210 |
| Sequential organocatalyzed Michael addition/[3 + 2]-heterocyclization for the stereoselective synthesis of fused-isoxazoline precursors of enantiopure cyclopentanoids. | Organic letters 20081204 |
| Design, synthesis, and biological evaluation of novel constrained meta-substituted phenyl propanoic acids as peroxisome proliferator-activated receptor alpha and gamma dual agonists. | Journal of medicinal chemistry 20081023 |
| Origins of stereoselectivity in the oxido-alkylidenation of alkynes. | Organic letters 20081016 |
| Total synthesis of potent antitumor agent (-)-lasonolide A: a cycloaddition-based strategy. | Chemistry, an Asian journal 20081006 |
| Novel terphenyls and 3,5-diaryl isoxazole derivatives endowed with growth supporting and antiapoptotic properties. | Journal of medicinal chemistry 20080814 |
| Synthesis and antimycobacterial activity of 4-[5-(substituted phenyl)-4, 5-dihydro-3-isoxazolyl]-2-methylphenols. | Journal of enzyme inhibition and medicinal chemistry 20080601 |
| Conversion of oximes to carbonyl compounds by triscetylpyridinium tetrakis(oxodiperoxotungsto) phosphate (PCWP)-mediated oxidation with hydrogen peroxide. | Molecules (Basel, Switzerland) 20080601 |
| 2,5-Dimethyl-3-(3-methyl-thio-phen-2-yl)perhydro-pyrrolo[3,4-d]isoxazole-4,6-dione. | Acta crystallographica. Section E, Structure reports online 20080601 |
| Double-blind, placebo-controlled, multiple-ascending-dose study on the effects of ABIO-08/01, a novel anxiolytic drug, on perception and cognition, utilizing event-related potential mapping and low-resolution brain electromagnetic tomography. | Human psychopharmacology 20080401 |
| Synthesis of novel pyrrolo[3,4-d]pyrazole-dicarboxylic acids and evaluation of their interaction with glutamate receptors. | Chemistry & biodiversity 20080401 |
| Synthesis of novel steroidal D-ring substituted isoxazoline derivatives of 17-oxoandrostanes. | Steroids 20080301 |
| 4'-Methyl-3-(4-nitro-phen-yl)-4-phenyl-4,5,1',2',3',4'-hexa-hydro-spiro-[isoxazole-5,2'-naphthalen]-1'-one. | Acta crystallographica. Section E, Structure reports online 20080201 |
| Synthesis of some new quinazolin-4-one derivatives and evaluation of their antimicrobial and antiinflammatory effects. | Acta poloniae pharmaceutica 20080101 |
| Discovery of novel isoxazolines as anti-tuberculosis agents. | Bioorganic & medicinal chemistry letters 20071201 |
| Asymmetric hydroformylation of vinyl acetate: application in the synthesis of optically active isoxazolines and imidazoles. | Organic letters 20070705 |
| Bis- and trisuracil nucleosides with nucleobases anchored to 11-, 12-, and 16-membered macrocyclic scaffolds: synthesis and aggregation study. | The Journal of organic chemistry 20070622 |
| In vitro, ex vivo and in vivo immunopharmacological activities of the isoxazoline compound VGX-1027: modulation of cytokine synthesis and prevention of both organ-specific and systemic autoimmune diseases in murine models. | Clinical immunology (Orlando, Fla.) 20070601 |
| A spiroisoxazolinoproline-based amino acid scaffold for solid phase and one-bead-one-compound library synthesis. | Journal of combinatorial chemistry 20070101 |
| Isoxazole-type derivatives related to combretastatin A-4, synthesis and biological evaluation. | Bioorganic & medicinal chemistry 20060615 |
| Synthesis and biological evaluation of phosphonated dihydroisoxazole nucleosides. | Bioorganic & medicinal chemistry 20060601 |
| Synthesis of new nitrogen analogues of salacinol and deoxynojirimycin and their evaluation as glycosidase inhibitors. | The Journal of organic chemistry 20060203 |
| Activated chemical defense in aplysina sponges revisited. | Journal of chemical ecology 20060101 |
| Sequestration and possible role of dietary alkaloids in the sponge-feeding mollusk Tylodina perversa. | Progress in molecular and subcellular biology 20060101 |
| Synthesis of new 2-thiouracil-5-sulphonamide derivatives with antibacterial and antifungal activity. | Archives of pharmacal research 20051101 |
| Heterocyclic ring scaffolds as small-molecule cholesterol absorption inhibitors. | Organic & biomolecular chemistry 20051007 |
| Exploring the scope of the 29G12 antibody catalyzed 1,3-dipolar cycloaddition reaction. | The Journal of organic chemistry 20050930 |
| Highly sensitive chiral shift reagent bearing two zinc porphyrins. | Organic letters 20050901 |
| Heterocyclic and phenyl double-bond-locked combretastatin analogues possessing potent apoptosis-inducing activity in HL60 and in MDR cell lines. | Journal of medicinal chemistry 20050210 |
| Chemical and biochemical transformations of 5-ethoxycarbonyl-5-phenyl-2-isoxazolines. | Farmaco (Societa chimica italiana : 1989) 20050101 |
| Stereochemically rich pentaketides from bis(isoxazolines): a general strategy for efficient polyketide synthesis. | Organic letters 20040708 |
| One-pot synthesis of functionalized 4,5-dihydroisoxazole derivatives via nitrile oxides and biological evaluation with plant cells. | Bioorganic & medicinal chemistry 20040102 |
| Chemical defense of Mediterranean sponges Aplysina cavernicola and Aplysina aerophoba. | Zeitschrift fur Naturforschung. C, Journal of biosciences 20040101 |
| Ionic liquid as a suitable phase for multistep parallel synthesis of an array of isoxazolines. | Organic letters 20031030 |
| Solution-phase synthesis of novel delta2-isoxazoline libraries via 1,3-dipolar cycloaddition and their antifungal properties. | Bioorganic & medicinal chemistry 20031015 |
| Stereoselective total synthesis of racemic BCX-1812 (RWJ-270201) for the development of neuraminidase inhibitors as anti-influenza agents. | The Journal of organic chemistry 20030822 |
| Discovery of 3-amino-4-chlorophenyl P1 as a novel and potent benzamidine mimic via solid-phase synthesis of an isoxazoline library. | Bioorganic & medicinal chemistry letters 20030519 |
| Stereoselective synthesis of alpha- and beta-glycosylamide derivatives from glycopyranosyl azides via isoxazoline intermediates. | Journal of the American Chemical Society 20030416 |
| alpha-Keto amides as precursors to heterocycles--generation and cycloaddition reactions of piperazin-5-one nitrones. | Organic & biomolecular chemistry 20030407 |
| Solid-phase synthesis of pyrazolines and isoxazolines with sodium benzenesulfinate as a traceless linker. | Organic letters 20030403 |
| Identification of phenylisoxazolines as novel and viable antibacterial agents active against Gram-positive pathogens. | Journal of medicinal chemistry 20030116 |
| Sequestration of dietary alkaloids by the spongivorous marine mollusc Tylodina perversa. | Zeitschrift fur Naturforschung. C, Journal of biosciences 20030101 |
| Effect of cyclooxygenase-2 (COX-2) inhibitors on prostate cancer cell proliferation. | Anticancer research 20030101 |
| Molybdenum-mediated cleavage reactions of isoxazoline rings fused in bicyclic frameworks. | Organic letters 20021114 |
| Efficient entry to highly functionalized beta-lactams by regio- and stereoselective 1,3-dipolar cycloaddition reaction of 2-azetidinone-tethered nitrones. Synthetic applications. | The Journal of organic chemistry 20021004 |
| Inhibition of the antibacterial target UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC): isoxazoline zinc amidase inhibitors bearing diverse metal binding groups. | Journal of medicinal chemistry 20020912 |
| Cycloserine fatty acid derivatives as prodrugs: synthesis, degradation and in vitro skin permeability. | Chemical & pharmaceutical bulletin 20020401 |
| Solid-phase synthesis of isoxazoles using vinyl ethers as chameleon catches. | Organic letters 20011004 |
| A novel disaccharide substrate having 1,2-oxazoline moiety for detection of transglycosylating activity of endoglycosidases. | Biochimica et biophysica acta 20010903 |
| Design and synthesis of 4,5-diphenyl-4-isoxazolines: novel inhibitors of cyclooxygenase-2 with analgesic and antiinflammatory activity. | Journal of medicinal chemistry 20010830 |
| Anti-influenza virus activities of 2-alkoxyimino-n-(2-isoxazolin-3-ylmethyl)acetamides. | Bioorganic & medicinal chemistry letters 20010806 |
| 3-(p-chlorophenyl)-4-phenyl-4,5-dihydroisoxazole-5-spiro-2'-1',2',3',4'-tetrahydronaphthalen-1'-one. | Acta crystallographica. Section C, Crystal structure communications 20010701 |
| Simultaneous discrimination of diastereotopic groups and faces: the first example in intramolecular [3+2] and [2+2+1] cycloaddition reactions. | The Journal of organic chemistry 20010601 |
| The design and synthesis of noncovalent factor Xa inhibitors. | Current topics in medicinal chemistry 20010601 |
| (10Z)- and (10E)-19-fluoro-1alpha,25-dihydroxyvitamin D3: an improved synthesis via 19-nor-10-oxo-vitamin D. | Chemical & pharmaceutical bulletin 20010301 |
| Discovery of 1-[3-(aminomethyl)phenyl]-N-3-fluoro-2'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a highly potent, selective, and orally bioavailable inhibitor of blood coagulation factor Xa. | Journal of medicinal chemistry 20010215 |
| TT dinucleotides containing an isoxazoline moiety: synthesis and binding affinity study. | Nucleosides, nucleotides & nucleic acids 20010101 |
Related Products
Featured Products
© 2019 Angene International Limited. All rights Reserved.