CAS 500-38-9 | Nordihydroguaiaretic acid | CAS Number 500-38-9

Title	Journal
Detoxification of benzo[a]pyrene primarily depends on cytochrome P450, while bioactivation involves additional oxidoreductases including 5-lipoxygenase, cyclooxygenase, and aldo-keto reductase in the liver.	Journal of biochemical and molecular toxicology 20170701
Nordihydroguiaretic acid attenuates skin tumorigenesis in Swiss albino mice with the condition of topical co-administration of an immunosuppressant.	Chemico-biological interactions 20150525
Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein.	Toxicological sciences : an official journal of the Society of Toxicology 20150201
Restraining the flexibility of the central linker in terameprocol results in constrained analogs with improved growth inhibitory activity.	Bioorganic & medicinal chemistry letters 20131115
Small molecule activators of the Nrf2-HO-1 antioxidant axis modulate heme metabolism and inflammation in BV2 microglia cells.	Pharmacological research 20131001
Rat α-Fetoprotein binding affinities of a large set of structurally diverse chemicals elucidated the relationships between structures and binding affinities.	Chemical research in toxicology 20121119
mTORC1 is a target of nordihydroguaiaretic acid to prevent breast tumor growth in vitro and in vivo.	Breast cancer research and treatment 20121101
Arachidonic acid stimulates DNA synthesis in brown preadipocytes through the activation of protein kinase C and MAPK.	Biochimica et biophysica acta 20121001
Synthesis and SAR studies of 3-allyl-4-prenyloxyaniline amides as potent 15-lipoxygenase inhibitors.	Bioorganic & medicinal chemistry 20120915
Phenolic compound production in relation to differentiation in cell and tissue cultures of Larrea divaricata (Cav.).	Plant science : an international journal of experimental plant biology 20120901
Synthesis of sulfur containing dihydro-pyrrolo derivatives and their biological evaluation as antioxidants.	Bioorganic & medicinal chemistry 20120901
Natural polyphenols as modulators of TTR amyloidogenesis: in vitro and in vivo evidences towards therapy.	Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 20120601
Subepithelial trypsin induces enteric nerve-mediated anion secretion by activating proteinase-activated receptor 1 in the mouse cecum.	The journal of physiological sciences : JPS 20120501
Novel NSAID 1-acyl-4-cycloalkyl/arylsemicarbazides and 1-acyl-5-benzyloxy/hydroxy carbamoylcarbazides as potential anticancer agents and antioxidants.	European journal of medicinal chemistry 20120501
Phase I study of terameprocol in patients with recurrent high-grade glioma.	Neuro-oncology 20120401
Dihydroceramide accumulation and reactive oxygen species are distinct and nonessential events in 4-HPR-mediated leukemia cell death.	Biochemistry and cell biology = Biochimie et biologie cellulaire 20120401
The protective effect of nordihydroguaiaretic acid on cerebral ischemia/reperfusion injury is mediated by the JNK pathway.	Brain research 20120322
The dietary supplementation of nordihydroguaiaretic acid (NDGA) delayed the loss of climbing ability in Drosophila model of Parkinson's disease.	Journal of dietary supplements 20120301
Signaling pathways activated by the phytochemical nordihydroguaiaretic acid contribute to a Keap1-independent regulation of Nrf2 stability: Role of glycogen synthase kinase-3.	Free radical biology & medicine 20120115
Α-aryl-N-alkyl nitrones, as potential agents for stroke treatment: synthesis, theoretical calculations, antioxidant, anti-inflammatory, neuroprotective, and brain-blood barrier permeability properties.	Journal of medicinal chemistry 20120112
A phase II study of insulin-like growth factor receptor inhibition with nordihydroguaiaretic acid in men with non-metastatic hormone-sensitive prostate cancer.	Oncology reports 20120101
Hypoxia promotes rabbit pulmonary artery smooth muscle cells proliferation through a 15-LOX-2 product 15(S)-hydroxyeicosatetraenoic acid.	Prostaglandins, leukotrienes, and essential fatty acids 20120101
Fragment-based design, docking, synthesis, biological evaluation and structure-activity relationships of 2-benzo/benzisothiazolimino-5-aryliden-4-thiazolidinones as cycloxygenase/lipoxygenase inhibitors.	European journal of medicinal chemistry 20120101
Interleukin-1 induction of aggrecanase gene expression in human articular chondrocytes is mediated by mitogen-activated protein kinases.	Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101
Jasmonic acid is involved in the signaling pathway for fungal endophyte-induced volatile oil accumulation of Atractylodes lancea plantlets.	BMC plant biology 20120101
Arachidonic acid and its COX1/2 metabolites inhibit interferon-γ mediated induction of indoleamine-2,3 dioxygenase in THP-1 cells and human monocytes.	Prostaglandins, leukotrienes, and essential fatty acids 20120101
Evaluation of the antioxidative properties of lipoxygenase inhibitors.	Pharmacological reports : PR 20120101
cPLA(2)α gene activation by IL-1β is dependent on an upstream kinase pathway, enzymatic activation and downstream 15-lipoxygenase activity: a positive feedback loop.	Cellular signalling 20111201
Effects of hypolipidemic agent nordihydroguaiaretic acid on lipid droplets and hepatitis C virus.	Hepatology (Baltimore, Md.) 20111201
Synthesis and biological evaluation of (2,5-dihydro-1H-pyrrol-1-yl)-2H-chromen-2-ones as free radical scavengers.	European journal of medicinal chemistry 20111201
Alteration in inflammatory/apoptotic pathway and histone modifications by nordihydroguaiaretic acid prevents acute pancreatitis in swiss albino mice.	Apoptosis : an international journal on programmed cell death 20111101
Design, synthesis and biological evaluation of benzo[1.3.2]dithiazolium ylide 1,1-dioxide derivatives as potential dual cyclooxygenase-2/5-lipoxygenase inhibitors.	Bioorganic & medicinal chemistry 20111101
Bioassay-guided identification of an anti-inflammatory prenylated acylphloroglucinol from Melicope ptelefolia and molecular insights into its interaction with 5-lipoxygenase.	Bioorganic & medicinal chemistry 20111101
Significant biological role of sp1 transactivation in multiple myeloma.	Clinical cancer research : an official journal of the American Association for Cancer Research 20111015
Tumor-associated macrophages mediate immunosuppression in the renal cancer microenvironment by activating the 15-lipoxygenase-2 pathway.	Cancer research 20111015
Effects of transient receptor potential channel blockers on pacemaker activity in interstitial cells of Cajal from mouse small intestine.	Molecules and cells 20110831
The lipogenesis pathway as a cancer target.	Journal of medicinal chemistry 20110825
Thrombin inhibitors with lipid peroxidation and lipoxygenase inhibitory activities.	Bioorganic & medicinal chemistry letters 20110815
Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.	Journal of medicinal chemistry 20110811
Development of Neh2-luciferase reporter and its application for high throughput screening and real-time monitoring of Nrf2 activators.	Chemistry & biology 20110624
An inhibitor of arachidonate 5-lipoxygenase, Nordy, induces differentiation and inhibits self-renewal of glioma stem-like cells.	Stem cell reviews 20110601
Synthesis, in silico docking experiments of new 2-pyrrolidinone derivatives and study of their anti-inflammatory activity.	Bioorganic & medicinal chemistry 20110501
Melittin activates TRPV1 receptors in primary nociceptive sensory neurons via the phospholipase A2 cascade pathways.	Biochemical and biophysical research communications 20110429
Modulation of lipid peroxidation and mitochondrial function improves neuropathology in Huntington's disease mice.	Acta neuropathologica 20110401
ABA controls H₂O₂ accumulation through the induction of OsCATB in rice leaves under water stress.	Plant & cell physiology 20110401
Discovery of a small molecule PDI inhibitor that inhibits reduction of HIV-1 envelope glycoprotein gp120.	ACS chemical biology 20110318
Involvement of H-Ras and reactive oxygen species in proinflammatory cytokine-induced matrix metalloproteinase-13 expression in human articular chondrocytes.	Archives of biochemistry and biophysics 20110315
Role of arachidonic acid lipoxygenase metabolites in acetylcholine-induced relaxations of mouse arteries.	American journal of physiology. Heart and circulatory physiology 20110301
Activated oncogenic pathways and therapeutic targets in extranodal nasal-type NK/T cell lymphoma revealed by gene expression profiling.	The Journal of pathology 20110301
Removal of the toxic effects of chlormadinon acetate on the development of Drosophila melanogaster via the use of nordihydroguaiaretic acid.	Toxicology and industrial health 20110201
Localization of lipoxygenase activity on the oil bodies and in protoplasts using a novel fluorescence imaging method.	Plant physiology and biochemistry : PPB 20110201
Topical anti-inflammatory activity of boropinic acid and its natural and semi-synthetic derivatives.	Bioorganic & medicinal chemistry letters 20110115
The complement component C5a is present in human coronary lesions in vivo and induces the expression of MMP-1 and MMP-9 in human macrophages in vitro.	FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110101
Adrenocorticotrophic hormone-stimulated cortisol release by the head kidney inter-renal tissue from sea bream (Sparus aurata) fed with linseed oil and soyabean oil.	The British journal of nutrition 20110101
Analysis of nordihydroguaiaretic acid in Larrea divaricata Cav. extracts by micellar electrokinetic chromatography.	Phytochemical analysis : PCA 20110101
Design, synthesis and pharmacobiological evaluation of novel acrylic acid derivatives acting as lipoxygenase and cyclooxygenase-1 inhibitors with antioxidant and anti-inflammatory activities.	European journal of medicinal chemistry 20110101
Terameprocol (tetra-O-methyl nordihydroguaiaretic acid), an inhibitor of Sp1-mediated survivin transcription, induces radiosensitization in non-small cell lung carcinoma.	Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20110101
Glycosylated nordihydroguaiaretic acids as anti-cancer agents.	Bioorganic & medicinal chemistry letters 20110101
One-pot microwave assisted synthesis under green chemistry conditions, antioxidant screening, and cytotoxicity assessments of benzimidazole Schiff bases and pyrimido[1,2-a]benzimidazol-3(4H)-ones.	European journal of medicinal chemistry 20110101
Inhibitory effect of nordihydroguaiaretic acid on β-catenin/Tcf signalling in β-catenin-activated cells.	Cell biochemistry and function 20110101
Dynein/Dynactin-mediated transport of kinetochore components off kinetochores and onto spindle poles induced by nordihydroguaiaretic acid.	PloS one 20110101
Nordihydroguaiaretic acid (NDGA) inhibits ritonavir-induced endothelial dysfunction in porcine pulmonary arteries.	Medical science monitor : international medical journal of experimental and clinical research 20110101
Anti-inflammatory and redox-protective activities of citronellal.	Biological research 20110101
Life extension by diet restriction and N-acetyl-L-cysteine in genetically heterogeneous mice.	The journals of gerontology. Series A, Biological sciences and medical sciences 20101201
Convenient synthesis and biological profile of 5-amino-substituted 1,2,4-oxadiazole derivatives.	European journal of medicinal chemistry 20101201
Inhibition of poxvirus growth by Terameprocol, a methylated derivative of nordihydroguaiaretic acid.	Antiviral research 20101201
Does conjugation of antioxidants improve their antioxidative/anti-inflammatory potential?	Bioorganic & medicinal chemistry 20101201
Role of leukotriene B4 in celecoxib-mediated anticancer effect.	Biochemical and biophysical research communications 20101112
Hepatoma-derived growth factor promotes the resistance to anti-tumor effects of nordihydroguaiaretic acid in colorectal cancer cells.	European journal of pharmacology 20101025
Nordihydroguaiaretic acid protects against high-fat diet-induced fatty liver by activating AMP-activated protein kinase in obese mice.	Biochemical and biophysical research communications 20101008
Synthesis and biological evaluation of indomethacin analogs possessing a N-difluoromethyl-1,2-dihydropyrid-2-one ring system: a search for novel cyclooxygenase and lipoxygenase inhibitors.	Bioorganic & medicinal chemistry letters 20101001
In vitro growth-inhibitory effect of plant-derived extracts and compounds against Paenibacillus larvae and their acute oral toxicity to adult honey bees.	Veterinary microbiology 20100928
Design, synthesis, and biological evaluation of prenylated chalcones as 5-LOX inhibitors.	Bioorganic & medicinal chemistry 20100815
Structure-activity relationship studies of acridones as potential antipsoriatic agents. 1. Synthesis and antiproliferative activity of simple N-unsubstituted 10H-acridin-9-ones against human keratinocyte growth.	European journal of medicinal chemistry 20100801
Synthesis and biological screening of some novel amidocarbamate derivatives of ketoprofen.	European journal of medicinal chemistry 20100701
A novel synthesis of 3-aryl coumarins and evaluation of their antioxidant and lipoxygenase inhibitory activity.	Bioorganic & medicinal chemistry letters 20100701
Mechanism of the OH radical scavenging activity of nordihydroguaiaretic acid: a combined theoretical and experimental study.	The journal of physical chemistry. B 20100520
Characterization and modulation of canine mast cell derived eicosanoids.	Veterinary immunology and immunopathology 20100515
Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19).	Bioorganic & medicinal chemistry letters 20100515
Molecular mechanisms and clinical applications of nordihydroguaiaretic acid (NDGA) and its derivatives: an update.	Medical science monitor : international medical journal of experimental and clinical research 20100428
[Nordihydroguaiaretic acid partially inhibits inflammatory responses after focal cerebral ischemia in rats].	Sheng li xue bao : [Acta physiologica Sinica] 20100425
[Elucidation of mechanism underlying amyloid-beta peptide aggregation and its neurotoxicity expression and inhibition of these molecular processes by beneficial synthetic and natural compounds with low-molecular weights-new approaches to fundamental treatment and prevention of Alzheimer's disease].	Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20100401
[Ganglioside cluster-mediated aggregation and cytotoxicity of amyloid beta-peptide: molecular mechanism and inhibition].	Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20100401
In vitro immunomodulatory effects of fractions obtained from aqueous extracts of Larrea divaricata Cav (Jarilla) on mouse peritoneal macrophages.	Immunopharmacology and immunotoxicology 20100301
Rescue of ER oxidoreductase function through polyphenolic phytochemical intervention: implications for subcellular traffic and neurodegenerative disorders.	Biochemical and biophysical research communications 20100219
A novel porous collagen scaffold around an implantable biosensor for improving biocompatibility. II. Long-term in vitro/in vivo sensitivity characteristics of sensors with NDGA- or GA-crosslinked collagen scaffolds.	Journal of biomedical materials research. Part A 20100201
Crosslinking effect of Nordihydroguaiaretic acid (NDGA) on decellularized heart valve scaffold for tissue engineering.	Journal of materials science. Materials in medicine 20100201
The direct effect of levobupivacaine in isolated rat aorta involves lipoxygenase pathway activation and endothelial nitric oxide release.	Anesthesia and analgesia 20100201
Phenylacetic acid regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.	Bioorganic & medicinal chemistry letters 20100201
ROCK pathway participates in the processes that 15-hydroxyeicosatetraenoic acid (15-HETE) mediated the pulmonary vascular remodeling induced by hypoxia in rat.	Journal of cellular physiology 20100101
Syntheses and evaluation of the antioxidant activity of acitretin analogs with amide bond(s) in the polyene spacer.	European journal of medicinal chemistry 20100101
Inhibitory activity of Brazilian green propolis components and their derivatives on the release of cys-leukotrienes.	Bioorganic & medicinal chemistry 20100101
Oxidative stress in NSC-741909-induced apoptosis of cancer cells.	Journal of translational medicine 20100101
Metabolic engineering of resveratrol and other longevity boosting compounds.	BioFactors (Oxford, England) 20100101
Synthesis and anti-inflammatory evaluation of novel angularly or linearly fused coumarins.	European journal of medicinal chemistry 20091201
A cell-based assay for screening lipoxygenase inhibitors.	Prostaglandins & other lipid mediators 20091201
Natural and synthetic 2'-hydroxy-chalcones and aurones: synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity.	Bioorganic & medicinal chemistry 20091201
Phenolic compounds prevent Alzheimer's pathology through different effects on the amyloid-beta aggregation pathway.	The American journal of pathology 20091201
Assembly of an intact Golgi complex requires phospholipase A2 (PLA2) activity, membrane tubules, and dynein-mediated microtubule transport.	Biochemical and biophysical research communications 20091120
Synthesis of modified homo-N-nucleosides from the reactions of mesityl nitrile oxide with 9-allylpurines and their influence on lipid peroxidation and thrombin inhibition.	Bioorganic & medicinal chemistry letters 20091115
CYP-omega-hydroxylation-dependent metabolites of arachidonic acid inhibit the basolateral 10 pS chloride channel in the rat thick ascending limb.	Kidney international 20091001
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.	Nature chemical biology 20091001
Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes.	Journal of natural products 20091001
A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta.	Bioorganic & medicinal chemistry letters 20090901
Nordihydroguaiaretic acid inhibits transforming growth factor beta type 1 receptor activity and downstream signaling.	European journal of pharmacology 20090815
Synthesis, characterization, and anti-melanoma activity of tetra-O-substituted analogs of nordihydroguaiaretic acid.	Bioorganic & medicinal chemistry letters 20090815
Cannabidiol-2',6'-dimethyl ether, a cannabidiol derivative, is a highly potent and selective 15-lipoxygenase inhibitor.	Drug metabolism and disposition: the biological fate of chemicals 20090801
Urea and carbamate derivatives of primaquine: synthesis, cytostatic and antioxidant activities.	Bioorganic & medicinal chemistry 20090801
Reactive oxygen species and lipoxygenases regulate the oncogenicity of NPM-ALK-positive anaplastic large cell lymphomas.	Oncogene 20090723
Synthesis and evaluation of the antioxidant and anti-inflammatory activity of novel coumarin-3-aminoamides and their alpha-lipoic acid adducts.	European journal of medicinal chemistry 20090701
Jasmonic acid is induced in a biphasic manner in response of pea seedlings to wounding.	Journal of integrative plant biology 20090601
Rethinking a drug treatment failure on a traditional ALS target.	Experimental neurology 20090401
5-Lipoxygenase plays a role in the control of parasite burden and contributes to oxidative damage of erythrocytes in murine Chagas' disease.	Immunology letters 20090324
Glucose-induced delay of seed germination in rice is mediated by the suppression of ABA catabolism rather than an enhancement of ABA biosynthesis.	Plant & cell physiology 20090301
Synthesis of hydroxycoumarins and hydroxybenzo[f]- or [h]coumarins as lipid peroxidation inhibitors.	Bioorganic & medicinal chemistry letters 20090215
Hypoxia suppresses KV1.5 channel expression through endogenous 15-HETE in rat pulmonary artery.	Prostaglandins & other lipid mediators 20090101
Identification of xenoestrogens in food additives by an integrated in silico and in vitro approach.	Chemical research in toxicology 20090101
Inhibition of ovulation by a lipoxygenase inhibitor involves reduced cyclooxygenase-2 expression and prostaglandin E2 production in gonadotropin-primed immature rats.	Reproduction (Cambridge, England) 20090101
Post-treatment effects of erythropoietin and nordihydroguaiaretic acid on recovery from cisplatin-induced acute renal failure in the rat.	Journal of Korean medical science 20090101
Effects of celecoxib and nordihydroguaiaretic acid on puromycin aminonucleoside-induced nephrosis in the rat.	Journal of Korean medical science 20090101
The effect of nordihydroguaiaretic acid on iodoacetate-induced toxicity in cultured neurons.	Journal of biochemical and molecular toxicology 20090101
Substance P upregulates LTB4 in rat adherent macrophages from granuloma induced by KMnO4.	Neurotoxicity research 20090101
Nordihydroguaiaretic acid analogues: their chemical synthesis and biological activities.	Current topics in medicinal chemistry 20090101
Chemosensitizing effect of nordihydroguaiaretic acid and its tetra-acetylated derivative on parental and multiresistant TA3 mouse mammary adenocarcinoma cells.	In vivo (Athens, Greece) 20090101
Characterization of novel furan compounds on the basis of their radical scavenging activity and cytoprotective effects against glutamate- and lipopolysaccharide-induced insults.	Bioorganic & medicinal chemistry 20081215
Cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate and nordihydroguaiaretic acid inhibit human Kv1.5 currents independently of lipoxygenase.	European journal of pharmacology 20081214
Nordihydroguaiaretic acid activates the antioxidant pathway Nrf2/HO-1 and protects cerebellar granule neurons against oxidative stress.	Neuroscience letters 20081212
Ethylene and ABA interactions in the regulation of flower induction in Pharbitis nil.	Journal of plant physiology 20081201
Abscisic acid is involved in chitosan-induced resistance to tobacco necrosis virus (TNV).	Plant physiology and biochemistry : PPB 20081201
Overexpression of 5-lipoxygenase in colon polyps and cancer and the effect of 5-LOX inhibitors in vitro and in a murine model.	Clinical cancer research : an official journal of the American Association for Cancer Research 20081015
A novel porous collagen scaffold around an implantable biosensor for improving biocompatibility. I. In vitro/in vivo stability of the scaffold and in vitro sensitivity of the glucose sensor with scaffold.	Journal of biomedical materials research. Part A 20081001
Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice.	Aging cell 20081001
Conjugated linoleic acid-induced fat loss dependence on Delta6-desaturase or cyclooxygenase.	Obesity (Silver Spring, Md.) 20081001
Nordihydroguaiaretic acid inhibits an activated fibroblast growth factor receptor 3 mutant and blocks downstream signaling in multiple myeloma cells.	Cancer research 20080915
Nordihydroguaiaretic acid increases glutamate uptake in vitro and in vivo: therapeutic implications for amyotrophic lateral sclerosis.	Experimental neurology 20080901
Nordihydroguaiaretic acid autoxidation produces a schisandrin-like dibenzocyclooctadiene lignan.	Journal of natural products 20080901
The non-steroidal anti-inflammatory drugs protect mouse cochlea against acoustic injury.	The Tohoku journal of experimental medicine 20080901
Regulation of pro-inflammatory responses by lipoxygenases via intracellular reactive oxygen species in vitro and in vivo.	Experimental & molecular medicine 20080831
Inhibitory effects of nordihydroguaiaretic acid (NDGA) on the IGF-1 receptor and androgen dependent growth of LAPC-4 prostate cancer cells.	The Prostate 20080801
The differentiation-inducing effect of Nordy on HPV-16 subgenes-immortalized human endocervical cells H8.	Anti-cancer drugs 20080801
Synthesis and biological evaluation of 1-(benzenesulfonamido)-2-[5-(N-hydroxypyridin-2(1H)-one)]acetylene regioisomers: a novel class of 5-lipoxygenase inhibitors.	Bioorganic & medicinal chemistry letters 20080715
Sevoflurane and the feto-placental vasculature: the role of nitric oxide and vasoactive eicosanoids.	Anesthesia and analgesia 20080701
Nordihydroguaiaretic acid, a cytotoxic insulin-like growth factor-I receptor/HER2 inhibitor in trastuzumab-resistant breast cancer.	Molecular cancer therapeutics 20080701
Nordihydroguaiaretic acid restores expression of silenced E-cadherin gene in human breast cancer cell lines and xenografts.	Anti-cancer drugs 20080601
Phase I clinical trial of repeat dose terameprocol vaginal ointment in healthy female volunteers.	Sexually transmitted diseases 20080601
[Advances in the research of lipoxygenase inhibitors].	Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20080601
Future target molecules for influenza treatment.	Mini reviews in medicinal chemistry 20080501
Screening of 397 chemicals and development of a quantitative structure--activity relationship model for androgen receptor antagonism.	Chemical research in toxicology 20080401
New nordihydroguaiaretic acid derivatives as anti-HIV agents.	Bioorganic & medicinal chemistry letters 20080315
Effect of the interaction between lipoxygenase pathway and progesterone on the regulation of hydroxysteroid 11-Beta dehydrogenase 2 in cultured human term placental trophoblasts.	Biology of reproduction 20080301
Nordihydroguaiaretic acid attenuates potassium dichromate-induced oxidative stress and nephrotoxicity.	Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080301
Terameprocol, a novel site-specific transcription inhibitor with anticancer activity.	IDrugs : the investigational drugs journal 20080301
Nordihydroguaiaretic acid (NDGA), an inhibitor of the HER2 and IGF-1 receptor tyrosine kinases, blocks the growth of HER2-overexpressing human breast cancer cells.	Journal of cellular biochemistry 20080201
Cytosolic phospholipase A2 and arachidonic acid metabolites modulate ventilator-induced permeability increases in isolated mouse lungs.	Journal of applied physiology (Bethesda, Md. : 1985) 20080201
Unique proteomic features induced by a potential antiglioma agent, Nordy (dl-nordihydroguaiaretic acid), in glioma cells.	Proteomics 20080201
A pilot dose-escalation study of the effects of nordihydroguareacetic acid on hormone and prostate specific antigen levels in patients with relapsed prostate cancer.	BJU international 20080201
[Effect of nordy on the function of endothelial progenitor cells from human umbilical cord blood induced by vascular endothelial growth factor].	Yao xue xue bao = Acta pharmaceutica Sinica 20080201
Reactivation of methylation-silenced tumor suppressor gene p16INK4a by nordihydroguaiaretic acid and its implication in G1 cell cycle arrest.	Life sciences 20080130
The flavonoid quercetin regulates growth and gene expression in rat FRTL-5 thyroid cells.	Endocrinology 20080101
RANTES (CCL5) potentiates calcium ionophore in the production of LTB4 in rat adherent macrophages from granuloma induced by KMnO4: inhibiton by NDGA.	Pharmacological research 20080101
Antigenotoxic effect of nordihydroguaiaretic acid against chlormadinone acetate-induced genotoxicity in mice bone-marrow cells.	Journal of natural medicines 20080101
Organic extracts of Larrea divaricata Cav. induced apoptosis on tumoral MCF7 cells with an higher cytotoxicity than nordihydroguaiaretic acid or paclitaxel.	Journal of experimental therapeutics & oncology 20080101
Single-laboratory validated method for determination of nordihydroguaiaretic acid in chaparral-containing dietary supplements.	Journal of AOAC International 20080101
Inhibitory effect of nordihydroguaiaretic acid and its tetra-acetylated derivative on respiration and growth of adenocarcinoma TA3 and its multiresistant variant TA3MTX-R.	In vivo (Athens, Greece) 20080101
Nordihydroguaiaretic acid inhibits insulin-like growth factor signaling, growth, and survival in human neuroblastoma cells.	Journal of cellular biochemistry 20071215
Structure-activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2.	Bioorganic & medicinal chemistry 20071201
Copper-induced peroxidation of phosphatidylserine-containing liposomes is inhibited by nanomolar concentrations of specific antioxidants.	Chemistry and physics of lipids 20071201
Phase I/II clinical safety studies of terameprocol vaginal ointment.	Gynecologic oncology 20071201
Nordihydroguaiaretic acid increases endothelial nitric oxide synthase expression via the transcription factor AP-1.	DNA and cell biology 20071201
Synthesis and anti-inflammatory/antioxidant activities of some new ring substituted 3-phenyl-1-(1,4-di-N-oxide quinoxalin-2-yl)-2-propen-1-one derivatives and of their 4,5-dihydro-(1H)-pyrazole analogues.	Bioorganic & medicinal chemistry letters 20071201
Nordihydroguaiaretic acid induces astroglial death via glutathione depletion.	Journal of neuroscience research 20071101
Inhibition of L-type Ca2+ channel current and negative inotropy induced by arachidonic acid in adult rat ventricular myocytes.	American journal of physiology. Cell physiology 20071101
Inhibitory effect of nordihydroguaiaretic acid, a plant lignan, on Helicobacter pylori-associated gastric carcinogenesis in Mongolian gerbils.	Cancer science 20071101
Penta-acetyl geniposide-induced apoptosis involving transcription of NGF/p75 via MAPK-mediated AP-1 activation in C6 glioma cells.	Toxicology 20070905
A novel lipoxygenase inhibitor Nordy attenuates malignant human glioma cell responses to chemotactic and growth stimulating factors.	Journal of neuro-oncology 20070901
Synthesis and pharmacochemical evaluation of novel aryl-acetic acid inhibitors of lipoxygenase, antioxidants, and anti-inflammatory agents.	Bioorganic & medicinal chemistry 20070901
Lipoxygenase inhibitors induce death receptor 5/TRAIL-R2 expression and sensitize malignant tumor cells to TRAIL-induced apoptosis.	Cancer science 20070901
The anticancer activity of the transcription inhibitor terameprocol (meso-tetra-O-methyl nordihydroguaiaretic acid) formulated for systemic administration.	Anti-cancer drugs 20070901
Oxidation of the lignan nordihydroguaiaretic acid.	Chemical research in toxicology 20070901
[Effect of nordy on biological behaviors of malignant glioma cell line U87MG and the analysis of differential expression proteome].	Zhonghua bing li xue za zhi = Chinese journal of pathology 20070901
Correlation of Golgi localization of ZW10 and centrosomal accumulation of dynactin.	Biochemical and biophysical research communications 20070803
The anti-cancer compound Nordy inhibits CXCR4-mediated production of IL-8 and VEGF by malignant human glioma cells.	Journal of neuro-oncology 20070801
An Aging Interventions Testing Program: study design and interim report.	Aging cell 20070801
Inhibition of IGF-1R and lipoxygenase by nordihydroguaiaretic acid (NDGA) analogs.	Bioorganic & medicinal chemistry letters 20070715
Modification of sericin-free silk fibers for ligament tissue engineering application.	Journal of biomedical materials research. Part B, Applied biomaterials 20070701
A plant lignan, 3'-O-methyl-nordihydroguaiaretic acid, suppresses papillomavirus E6 protein function, stabilizes p53 protein, and induces apoptosis in cervical tumor cells.	Molecular carcinogenesis 20070701
Design and synthesis of novel quinolinone-3-aminoamides and their alpha-lipoic acid adducts as antioxidant and anti-inflammatory agents.	Journal of medicinal chemistry 20070517
Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti.	Journal of natural products 20070501
Regulation of topoisomerase II alpha and beta in HIV-1 infected and uninfected neuroblastoma and astrocytoma cells: involvement of distinct nordihydroguaretic acid sensitive inflammatory pathways.	Archives of biochemistry and biophysics 20070501
Endogenous production of reactive oxygen species is required for stimulation of human articular chondrocyte matrix metalloproteinase production by fibronectin fragments.	Free radical biology & medicine 20070501
Effect of heating on peroxynitrite scavenging capacity of garlic.	Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20070401
Tetra-O-methyl nordihydroguaiaretic acid inhibits growth and induces death of leukemia cells independent of Cdc2 and survivin.	Leukemia & lymphoma 20070401
Protective role of nordihydroguaiaretic acid (NDGA) against the genotoxic damage induced by ethynodiol diacetate in human lymphocytes in vitro.	Journal of environmental biology 20070401
Assessing 12(S)-lipoxygenase inhibitory activity using colorectal cancer cells overexpressing the enzyme.	Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20070301
[Effect of nordy on FPR function of malignant human glioma cell line U87].	Yao xue xue bao = Acta pharmaceutica Sinica 20070301
[Nordy inhibits cell proliferation and angiogenic factor production of malignant human glioma cells mediated by formylpeptide receptor].	Zhonghua yi xue za zhi 20070213
Nordihydroguaiaretic acid affects multiple dynein-dynactin functions in interphase and mitotic cells.	Molecular pharmacology 20070201
5-LOX inhibitor modulates the inflammatory responses provoked by Helicobacter pylori infection.	Helicobacter 20070201
Effects of arachidonate metabolism inhibitors on basal and human chorionic gonadotropin-stimulated progesterone secretion by rat corpus luteum cells in vitro.	Prostaglandins & other lipid mediators 20070201
Design and study of some novel ibuprofen derivatives with potential nootropic and neuroprotective properties.	Bioorganic & medicinal chemistry 20070115
Exploiting hypoxia in solid tumors to achieve oncolysis.	Medical hypotheses 20070101
Transport characteristics of a novel local drug delivery system using nordihydroguaiaretic acid (NDGA)-polymerized collagen fibers.	Biotechnology progress 20070101
Effect of hydroalcoholic extract of Zingiber officinalis rhizomes on LPS-induced rat airway hyperreactivity and lung inflammation.	Prostaglandins, leukotrienes, and essential fatty acids 20070101
Effects of inhibitors of the arachidonic acid cascade on primary muscle culture from a Duchenne muscular dystrophy patient.	Prostaglandins, leukotrienes, and essential fatty acids 20070101
Early effects triggered by Larrea divaricata Cav. on murine macrophages at apoptotic concentrations.	Immunopharmacology and immunotoxicology 20070101
Activation and apoptosis of mouse peritoneal macrophages by extracts of Larrea divaricata Cav. (jarilla).	International immunopharmacology 20061220
Enhancing engraftment of neonatal porcine xenoislet with CTLA4Ig and nordihydroguaiaretic acid.	Transplantation proceedings 20061201
Reversal of multidrug resistance by two nordihydroguaiaretic acid derivatives, M4N and maltose-M3N, and their use in combination with doxorubicin or paclitaxel.	Cancer chemotherapy and pharmacology 20061101
Neurotoxicity of lidocaine involves specific activation of the p38 mitogen-activated protein kinase, but not extracellular signal-regulated or c-jun N-terminal kinases, and is mediated by arachidonic acid metabolites.	Anesthesiology 20061101
Prooxidant activity and toxicity of nordihydroguaiaretic acid in clone-9 rat hepatocyte cultures.	Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20061001
5-Hydroxyeicosatetraenoic acid is a key intermediate of the arachidonate-dependent protective signaling in monocytes/macrophages exposed to peroxynitrite.	Journal of leukocyte biology 20061001
Effects of selective inhibition of cyclooxygenase and lipooxygenase pathways in follicle rupture and ovulation in the rat.	Reproduction (Cambridge, England) 20061001
Effects of hyposmotic stress on exocytosis in isolated turbot, Scophthalmus maximus, hepatocytes.	Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20060901
Oxidative stress-driven mechanisms of nordihydroguaiaretic acid-induced apoptosis in FL5.12 cells.	Toxicology and applied pharmacology 20060801
Survivin-dependent and -independent pathways and the induction of cancer cell death by tetra-O-methyl nordihydroguaiaretic acid.	Seminars in oncology 20060801
Single-cell enzyme concentrations, kinetics, and inhibition analysis using high-density hydrodynamic cell isolation arrays.	Analytical chemistry 20060715
Mechanisms regulating tumor angiogenesis by 12-lipoxygenase in prostate cancer cells.	The Journal of biological chemistry 20060707
The action of extracellular NAD+ on gluconeogenesis in the perfused rat liver.	Molecular and cellular biochemistry 20060601
Nordihydroguaiaretic acid is a potent in vitro scavenger of peroxynitrite, singlet oxygen, hydroxyl radical, superoxide anion and hypochlorous acid and prevents in vivo ozone-induced tyrosine nitration in lungs.	Free radical research 20060501
Nordy, a synthetic lipoxygenase inhibitor, inhibits the expression of formylpeptide receptor and induces differentiation of malignant glioma cells.	Biochemical and biophysical research communications 20060421
Overcoming trastuzumab resistance with nordihydroguaiaretic acid?	Breast cancer research and treatment 20060401
Alpha-lipoic acid exhibits anti-amyloidogenicity for beta-amyloid fibrils in vitro.	Biochemical and biophysical research communications 20060324
Synthesis and structure-activity relationship studies of 1,3-diarylprop-2-yn-1-ones: dual inhibitors of cyclooxygenases and lipoxygenases.	Journal of medicinal chemistry 20060309
Protective effect of nordihydroguaiaretic acid (NDGA) against norgestrel induced genotoxic damage.	Toxicology in vitro : an international journal published in association with BIBRA 20060301
Differential effect of saturated, monounsaturated, and polyunsaturated fatty acids on alloxan-induced diabetes mellitus.	Prostaglandins, leukotrienes, and essential fatty acids 20060301
Schisandrene, a dibenzocyclooctadiene lignan from Schisandra chinensis: structure-antioxidant activity relationships of dibenzocyclooctadiene lignans.	Journal of natural products 20060301
Effects of nordihydroguaiaretic acid on Na+ currents in rat dorsal root ganglion neurons.	Brain research 20060209
Increased angiogenic capabilities of endothelial cells from microvessels of malignant human gliomas.	International immunopharmacology 20060101
Glucose metabolism in isolated uteri of immature rats. Influence of prostaglandins and nitric oxide.	Reproduction, nutrition, development 20060101
Blockade of arachidonic acid pathway induces sprouting in the adult but not in the neonatal uncrossed retinotectal projection.	Neuroscience 20060101
Purification, product characterization and kinetic properties of lipoxygenase from olive fruit (Olea europaea L.).	Plant physiology and biochemistry : PPB 20060101
Eicosanoid-mediated proinflammatory activity of Pseudomonas aeruginosa ExoU.	Cellular microbiology 20051201
Structure-activity relationship of polyphenols that inhibit fatty acid synthase.	Journal of biochemistry 20051201
Nordihydroguaiaretic acid (NDGA) inhibits the IGF-1 and c-erbB2/HER2/neu receptors and suppresses growth in breast cancer cells.	Breast cancer research and treatment 20051101
Synthesis and biological evaluation of 1,3-diphenylprop-2-yn-1-ones as dual inhibitors of cyclooxygenases and lipoxygenases.	Bioorganic & medicinal chemistry letters 20051101
Synthesis and antiinflammatory activity of coumarin derivatives.	Journal of medicinal chemistry 20051006
Role of arachidonic acid in hyposmotic membrane stretch-induced increase in calcium-activated potassium currents in gastric myocytes.	Acta pharmacologica Sinica 20051001
The anti-apoptotic effects of nordihydroguaiaretic acid: inhibition of cPLA(2) activation during TNF-induced apoptosis arises from inhibition of calcium signaling.	Life sciences 20050923
15S-Lipoxygenase-2 mediates arachidonic acid-stimulated adhesion of human breast carcinoma cells through the activation of TAK1, MKK6, and p38 MAPK.	The Journal of biological chemistry 20050909
Conjugated linoleic acid, cis-9,trans-11, is a substrate for pulmonary 15-lipoxygenase-1 in rat.	Journal of agricultural and food chemistry 20050907
Effect of Larrea tridentata (creosote bush) on cholesterol gallstones and bile secretion in hamsters.	The Journal of pharmacy and pharmacology 20050901
5-Lipoxygenase inhibitors attenuate growth of human renal cell carcinoma and induce apoptosis through arachidonic acid pathway.	Oncology reports 20050701
Systemic treatment with tetra-O-methyl nordihydroguaiaretic acid suppresses the growth of human xenograft tumors.	Clinical cancer research : an official journal of the American Association for Cancer Research 20050615
Determination and confirmation of five phenolic antioxidants in foods by LC/MS and GC/MS.	Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20050601
The effects of nitric oxide synthase--versus lipoxygenase inhibition on coronary flow and nitrite outflow in isolated rat heart.	General physiology and biophysics 20050601
Survival prolongation of microencapsulated allogeneic islet by nanosized nordihydroguaiaretic acid.	Transplantation proceedings 20050501
Larrea tridentata (Creosote bush), an abundant plant of Mexican and US-American deserts and its metabolite nordihydroguaiaretic acid.	Journal of ethnopharmacology 20050426
Leukotriene and prostaglandin synthesis pathways in osteoarthritic synovial membranes: regulating factors for interleukin 1beta synthesis.	The Journal of rheumatology 20050401
Nordihydroguaiaretic acid inhibits IFN-gamma-induced STAT tyrosine phosphorylation in rat brain astrocytes.	Biochemical and biophysical research communications 20050311
Nordihydroguaiaretic acid (NDGA) blocks the differentiation of C2C12 myoblast cells.	Journal of cellular physiology 20050301
Tryptamine and homotryptamine-based sulfonamides as potent and selective inhibitors of 15-lipoxygenase.	Bioorganic & medicinal chemistry letters 20050301
CDC2/CDK1 expression in esophageal adenocarcinoma and precursor lesions serves as a diagnostic and cancer progression marker and potential novel drug target.	The American journal of surgical pathology 20050301
Sensitization of colon cancer cell lines to butyrate-mediated proliferation inhibition by combined application of indomethacin and nordihydroguaiaretic acid.	Cancer detection and prevention 20050101
Inhibition of influenza-virus-induced apoptosis in chorion cells of human fetal membranes by nordihydroguaiaretic Acid.	Intervirology 20050101
Anti-inflammatory effects of specific cyclooxygenase 2,5-lipoxygenase, and inducible nitric oxide synthase inhibitors on experimental autoimmune anterior uveitis (EAAU).	Ocular immunology and inflammation 20050101
The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis via induction of 15-lipoxygenase-1 in colorectal cancer cells.	Cancer research 20041201
New acylated iridoid glucosides from Vitex altissima.	Journal of natural products 20041201
Group IIA secretory phospholipase A2 is a unique 12/15-lipoxygenase-regulated gene in cytokine-stimulated rat fibroblastic 3Y1 cells.	Biochimica et biophysica acta 20041108
Anti-amyloidogenic activity of tannic acid and its activity to destabilize Alzheimer's beta-amyloid fibrils in vitro.	Biochimica et biophysica acta 20041105
Suppression of heat- and polyglutamine-induced cytotoxicity by nonsteroidal anti-inflammatory drugs.	European journal of biochemistry 20041101
Arachidonic acid regulation of steroid synthesis: new partners in the signaling pathway of steroidogenic hormones.	Endocrine research 20041101
Multiple contributions from long-chain fatty acid metabolism in Y-1 and MA-10 cells.	Endocrine research 20041101
The arachidonic acid 5-lipoxygenase inhibitor nordihydroguaiaretic acid inhibits tumor necrosis factor alpha activation of microglia and extends survival of G93A-SOD1 transgenic mice.	Journal of neurochemistry 20041001
Nordihydroguaiaretic acid-induced Ca2+ handling and cytotoxicity in human prostate cancer cells.	Life sciences 20040924
Lignoids in insects: chemical probes for the study of ecdysis, excretion and Trypanosoma cruzi-triatomine interactions.	Toxicon : official journal of the International Society on Toxinology 20040915
Nordihydroguairetic acid, a lignin, prevents oxidative stress and the development of diabetic nephropathy in rats.	Pharmacology 20040901
Nordihydroguaiaretic acid does not disaggregate beta-amyloid(1-40) protofibrils but does inhibit growth arising from direct protofibril association.	Molecular pharmacology 20040901
Stimulatory actions of caffeic acid phenethyl ester, a known inhibitor of NF-kappaB activation, on Ca2+-activated K+ current in pituitary GH3 cells.	The Journal of biological chemistry 20040625
A new lead compound for abscisic acid biosynthesis inhibitors targeting 9-cis-epoxycarotenoid dioxygenase.	Bioorganic & medicinal chemistry letters 20040621
Prostaglandin F(2alpha) is protective for apoptosis stimulated synergistically with 12-O-tetradecanoyl phorbol-beta-acetate and nordihydroguaiaretic acid in Madin-Darby canine kidney cells.	Biochimica et biophysica acta 20040601
Effect of Larrea divaricata Cav. extract and nordihydroguaiaretic acid upon peroxidase secretion in rat submandibulary glands.	Pharmacological research 20040501
Inhibitors of 5-lipoxygenase inhibit expression of intercellular adhesion molecule-1 in human melanoma cells.	Acta pharmacologica Sinica 20040501
BK2 but not BK1 receptors mediating contractile response in human umbilical arteries: role of thromboxane A2.	Methods and findings in experimental and clinical pharmacology 20040501
Involvement of spinal lipoxygenase metabolites in hyperalgesia and opioid tolerance.	European journal of pharmacology 20040426
Substance P can stimulate prostaglandin D2 and leukotriene C4 generation without granule exocytosis in murine mast cells.	European journal of pharmacology 20040405
Interleukin-17 signal transduction pathways implicated in inducing matrix metalloproteinase-3, -13 and aggrecanase-1 genes in articular chondrocytes.	Cellular signalling 20040401
Inhibition of AP-1 transcription activator induces myc-dependent apoptosis in HL60 cells.	Journal of cellular biochemistry 20040401
A stepwise dissection of the intracellular fate of cationic cell-penetrating peptides.	The Journal of biological chemistry 20040326
Curcumin has potent anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro.	Journal of neuroscience research 20040315
Adipocyte differentiation of multipotent cells established from human adipose tissue.	Biochemical and biophysical research communications 20040305
Determination of binding constant of transcription factor myc-max/max-max and E-box DNA: the effect of inhibitors on the binding.	Biochimica et biophysica acta 20040224
The effects of TNF-alpha and inhibitors of arachidonic acid metabolism on human colon HT-29 cells depend on differentiation status.	Differentiation; research in biological diversity 20040201
TGSA-Flex: Extending the capabilities of the Topo-Geometrical Superposition Algorithm to handle flexible molecules.	Journal of computational chemistry 20040130
Estrogenic activity of an antioxidant, nordihydroguaiaretic acid (NDGA).	Life sciences 20040130
Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake.	The Journal of biological chemistry 20040109
Tetrapetalone A, a novel lipoxygenase inhibitor from Streptomyces sp.	Bioscience, biotechnology, and biochemistry 20040101
Effects of eicosanoid biosynthesis inhibitors on the prophenoloxidase-activating system and microaggregation reactions in the hemolymph of Rhodnius prolixus infected with Trypanosoma rangeli.	Journal of insect physiology 20040101
15-LOX-1 inhibits p21 (Cip/WAF 1) expression by enhancing MEK-ERK 1/2 signaling in colon carcinoma cells.	Prostaglandins & other lipid mediators 20040101
Inhibitory action of ICI-182,780, an estrogen receptor antagonist, on BK(Ca) channel activity in cultured endothelial cells of human coronary artery.	Biochemical pharmacology 20031115
Dihydrolipoic acid inhibits 15-lipoxygenase-dependent lipid peroxidation.	Free radical biology & medicine 20031115
Lipoxygenase inhibitors enhance tumor suppressive effects of jun proteins on v-myb-transformed monoblasts BM2.	Prostaglandins & other lipid mediators 20031101
Adipocyte differentiation of 3T3-L1 preadipocytes is dependent on lipoxygenase activity during the initial stages of the differentiation process.	The Biochemical journal 20031101
Naturally occurring lignans efficiently induce apoptosis in colorectal tumor cells.	Journal of cancer research and clinical oncology 20031001
Nordihydroguaiaretic acid, an antioxidant, inhibits transforming growth factor-beta activity through the inhibition of Smad signaling pathway.	Experimental cell research 20031001
Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor.	Chemical research in toxicology 20031001
The role of oxidant-mediated pathways in the cytotoxicity of endothelial cells exposed to mesenteric lymph from rats subjected to trauma-hemorrhagic shock.	Shock (Augusta, Ga.) 20030901
Spinal administration of lipoxygenase inhibitors suppresses behavioural and neurochemical manifestations of naloxone-precipitated opioid withdrawal.	British journal of pharmacology 20030901
Nitric oxide triggers the toxicity due to glutathione depletion in midbrain cultures through 12-lipoxygenase.	The Journal of biological chemistry 20030613
Roles of 5-lipoxygenase activating protein in cell proliferation and apoptosis.	Cell biology and toxicology 20030601
Neuroprotection by the endogenous cannabinoid anandamide and arvanil against in vivo excitotoxicity in the rat: role of vanilloid receptors and lipoxygenases.	The Journal of neuroscience : the official journal of the Society for Neuroscience 20030515
Fatty acid release and oxidation are factors in lipoxygenase inhibitor-induced apoptosis.	Toxicology letters 20030303
Mechanical and thermal properties of novel polymerized NDGA-gelatin hydrogels.	Biomaterials 20030301
Inhibition of HSV-1 replication and reactivation by the mutation-insensitive transcription inhibitor tetra-O-glycyl-nordihydroguaiaretic acid.	Antiviral research 20030301
Novel antiviral agent tetraglycylated nordihydroguaiaretic acid hydrochloride as a host-dependent viral inhibitor.	Antiviral research 20030301
Oxidant-stimulated chloride secretion in rat jejunum in vitro is mediated by eicosanoids.	Digestive diseases and sciences 20030301
Direct interaction of the Golgi membrane with the endoplasmic reticulum membrane caused by nordihydroguaiaretic acid.	Biochemical and biophysical research communications 20030221
Inhibition by eicosapentaenoic acid of IL-1beta-induced PGHS-2 expression in human microvascular endothelial cells: involvement of lipoxygenase-derived metabolites and p38 MAPK pathway.	Biochimica et biophysica acta 20030220
Abnormalities in intracellular Ca2+ regulation in fetal vascular smooth muscle in pre-eclampsia: enhanced sensitivity to arachidonic acid.	FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030201
Contribution of 5- and 12-lipoxygenase products to mechanical hyperalgesia induced by prostaglandin E(2) and epinephrine in the rat.	Experimental brain research 20030201
Lipoxygenase products regulate nitric oxide and inducible nitric oxide synthase production in interleukin-1beta stimulated vascular smooth muscle cells.	Hypertension research : official journal of the Japanese Society of Hypertension 20030201
Mepanipyrim, a novel inhibitor of pharmacologically induced Golgi dispersion.	Bioscience, biotechnology, and biochemistry 20030101
Nordihydroguaiaretic acid, of a new family of microtubule-stabilizing agents, shows effects differentiated from paclitaxel.	Bioscience, biotechnology, and biochemistry 20030101
Eicosanoid precursor polyenoic fatty acids modulate synaptic levels of dopamine in ex-vivo slices of rat brain striatum.	In vivo (Athens, Greece) 20030101
[Effect of inhibitors of cyclooxygenase and lypoxygenase pathway of metabolism of arachidonic acid on the development and suppression of the immune response in mice].	Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20030101
Lipoxygenase inhibitors suppress proliferation of G5:113 fibrosarcoma cells in vitro but they have no anticancer activity in vivo.	Neoplasma 20030101
Prostaglandin F2alpha protected cultured Madin-Darby canine kidney cells from the development of apoptosis induced by 12-o-tetradecanoyl phorbol-beta-acetate and stimulated synergistically with nordihydroguaiaretic acid.	Advances in experimental medicine and biology 20030101
BAD and Bcl-2 regulation are early events linking neuronal endoplasmic reticulum stress to mitochondria-mediated apoptosis.	Brain research. Molecular brain research 20021230
Nordihydroguaiaretic acid: hepatotoxicity and detoxification in the mouse.	Toxicon : official journal of the International Society on Toxinology 20021201
Aberrant arachidonic acid metabolism in esophageal adenocarcinogenesis, and the effects of sulindac, nordihydroguaiaretic acid, and alpha-difluoromethylornithine on tumorigenesis in a rat surgical model.	Carcinogenesis 20021201
Concerted regulation of free arachidonic acid and hormone-induced steroid synthesis by acyl-CoA thioesterases and acyl-CoA synthetases in adrenal cells.	European journal of biochemistry 20021101
ACTH regulation of mitochondrial acyl-CoA thioesterase activity in Y1 adrenocortical tumour cells.	Endocrine research 20021101
Effect of nordihydroguaiaretic acid on intracellular Ca(2+) concentrations in hepatocytes.	Toxicology in vitro : an international journal published in association with BIBRA 20021001
Effect of nordihydroguaiaretic acid on the secretion of lipoprotein lipase.	Journal of biochemistry and molecular biology 20020930
Inhibition of peroxisome proliferator-activated receptor (PPAR)-mediated keratinocyte differentiation by lipoxygenase inhibitors.	The Biochemical journal 20020915
Design, synthesis, and biological evaluation of a cephalosporin-monohydroguaiaretic acid prodrug activated by a monoclonal antibody-beta-lactamase conjugate.	Bioorganic & medicinal chemistry 20020901
N-acylethanolamines are metabolized by lipoxygenase and amidohydrolase in competing pathways during cottonseed imbibition.	Plant physiology 20020901
Neurons overexpressing mutant presenilin-1 are more sensitive to apoptosis induced by endoplasmic reticulum-Golgi stress.	Journal of neuroscience research 20020815
Structure-activity relationship studies of nordihydroguaiaretic acid inhibitors toward soybean, 12-human, and 15-human lipoxygenase.	Journal of medicinal chemistry 20020606
Induction of MnSOD gene by arachidonic acid is mediated by reactive oxygen species and p38 MAPK signaling pathway in human HepG2 hepatoma cells.	Free radical biology & medicine 20020601
Participation of the arachidonic acid cascade pathway in macrophage binding/uptake of oxidized low density lipoprotein.	Biological & pharmaceutical bulletin 20020601
Nordihydroguaiaretic acid-mediated inhibition of ultraviolet B-induced activator protein-1 activation in human keratinocytes.	Molecular carcinogenesis 20020601
Effects of brefeldin A and nordihydroguaiaretic acid on endomembrane dynamics and lipid synthesis in plant cells.	FEBS letters 20020508
Effects of cyclooxygenase and lipoxygenase inhibition on basal- and serotonin-induced ion transport in rat colon.	Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20020501
Involvement of glycogen synthase kinase-3beta and tau phosphorylation in neuronal Golgi disassembly.	Journal of neurochemistry 20020501
Nordihydroguaiaretic acid potently breaks down pre-formed Alzheimer's beta-amyloid fibrils in vitro.	Journal of neurochemistry 20020501
Mechanisms underlying the activation of large conductance Ca2+-activated K+ channels by nordihydroguaiaretic acid.	Japanese journal of pharmacology 20020501
Mechanisms of nordihydroguaiaretic acid-induced growth inhibition and apoptosis in human cancer cells.	British journal of cancer 20020408
[Simultaneous determination of five antioxidants in food by HPLC with fluorescence detection].	Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20020401
Comparative quantitative structure toxicity relationships for flavonoids evaluated in isolated rat hepatocytes and HeLa tumor cells.	Chemico-biological interactions 20020320
Effect of nordihydroguaiaretic acid on intracellular Ca(2+) concentrations in C6 glioma cells.	Neurochemistry international 20020301
Possible implication of Golgi-nucleating function for the centrosome.	Biochemical and biophysical research communications 20020301
Expression and induction of the stress protein alpha-B-crystallin in vascular endothelial cells.	Histochemistry and cell biology 20020301
Effects of inhibitors of the lipo-oxygenase family of enzymes on the store-operated calcium current I(CRAC) in rat basophilic leukaemia cells.	The Journal of physiology 20020215
Tending tender tendons.	Science (New York, N.Y.) 20020208
5-Lipoxygenase and human pulmonary artery endothelial cell proliferation.	American journal of physiology. Heart and circulatory physiology 20020201
Differential effect of brefeldin A on the palmitoylation of surfactant protein C proprotein mutants.	Biochemical and biophysical research communications 20020111
The lipoxygenase pathways are involved in LH-stimulated progesterone production in bovine corpus luteum.	Prostaglandins & other lipid mediators 20020101
Cytosolic phospholipase A2 and lipoxygenase are involved in cell cycle progression in neuroblastoma cells.	Cellular and molecular life sciences : CMLS 20020101
[Effect of exogenous leukotrienes and lipoxygenase inhibitors on apoptosis and necrosis in cultured rat hepatocytes].	Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20020101
[Lipoxygenase inhibitors induce rat hepatocyte apoptosis in primary culture].	Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20020101
Regulation of apoptosis through arachidonate cascade in mammalian cells.	Applied biochemistry and biotechnology 20020101
Lipoxygenase inhibitors induce arrest of tumor cells in S-phase of the cell cycle.	Neoplasma 20020101
Progressive apoptosis in chorion laeve trophoblast cells of human fetal membrane tissues during in vitro incubation is suppressed by antioxidative reagents.	European journal of biochemistry 20011201
Nordihydroguaiaretic acid elevates osteoblastic intracellular Ca2+.	Pharmacology & toxicology 20011201
Synthesis and anticancer activity of nordihydroguaiaretic acid (NDGA) and analogues.	Anti-cancer drug design 20011201
Lipoxygenase inhibitors inhibit heparin-releasable lipoprotein lipase activity in 3T3-L1 adipocytes and enhance body fat reduction in mice by conjugated linoleic acid.	Biochimica et biophysica acta 20011130
5-lipoxygenase regulates malignant mesothelial cell survival: involvement of vascular endothelial growth factor.	FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20011101
Intracellular signaling pathway of FGF-2-modulated corneal endothelial cell migration during wound healing in vitro.	Experimental eye research 20011101
Eicosanoids participate in the regulation of cardiac glucose transport by contribution to a rearrangement of actin cytoskeletal elements.	The Biochemical journal 20011001
Histamine stimulates alveolar macrophages to release neutrophil and monocyte chemotactic activity.	The Journal of laboratory and clinical medicine 20011001
tetra-O-methylnordihydroguaiaretic acid inhibits melanoma in vivo.	Cancer letters 20010928
trans-10,cis-12-Conjugated linoleic acid reduces leptin secretion from 3T3-L1 adipocytes.	Biochemical and biophysical research communications 20010921
Differential role of cytosolic phospholipase A2 in the invasion of brain microvascular endothelial cells by Escherichia coli and Listeria monocytogenes.	The Journal of infectious diseases 20010915
Elevating dietary salt exacerbates hyperpnea-induced airway obstruction in guinea pigs.	Journal of applied physiology (Bethesda, Md. : 1985) 20010901
Pharmacological modulation of allergic inflammation in the rat airways and association with mast cell heterogeneity.	European journal of pharmacology 20010824
Johns Hopkins embroiled in fresh misconduct allegations.	Nature 20010802
Characterization of clofibrate-induced retrograde Golgi membrane movement to the endoplasmic reticulum: clofibrate distinguishes the Golgi from the trans Golgi network.	Bioscience, biotechnology, and biochemistry 20010801
Baicalein protects cortical neurons from beta-amyloid (25-35) induced toxicity.	Neuroreport 20010720
Tetra-O-methyl nordihydroguaiaretic acid induces G2 arrest in mammalian cells and exhibits tumoricidal activity in vivo.	Cancer research 20010715
Inhibitors of arachidonic acid metabolism potentiate tumour necrosis factor-alpha-induced apoptosis in HL-60 cells.	European journal of pharmacology 20010713
Biocompatibility of NDGA-polymerized collagen fibers. I. Evaluation of cytotoxicity with tendon fibroblasts in vitro.	Journal of biomedical materials research 20010701
Biocompatibility of NDGA-polymerized collagen fibers. II. Attachment, proliferation, and migration of tendon fibroblasts in vitro.	Journal of biomedical materials research 20010701
Activation of cardiac afferents by arachidonic acid: relative contributions of metabolic pathways.	American journal of physiology. Heart and circulatory physiology 20010701
Glucosylceramide synthesis inhibitors block pharmacologically induced dispersal of the Golgi and anterograde membrane flow from the endoplasmic reticulum: implication of sphingolipid metabolism in maintenance of the Golgi architecture and anterograde membrane flow.	Bioscience, biotechnology, and biochemistry 20010601
Disparate effects of similar phenolic phytochemicals as inhibitors of oxidative damage to cellular DNA.	Mutation research 20010510
Mechanisms of cytokine-induced death of cultured bovine luteal cells.	Reproduction (Cambridge, England) 20010501
Pharmacokinetic analysis by high-performance liquid chromatography of intravenous nordihydroguaiaretic acid in the mouse.	Journal of chromatography. B, Biomedical sciences and applications 20010415
Modulation of the immediate allergic wheal reaction in the skin by drugs inhibiting the effects of leukotriene C4 and prostaglandin D2.	European journal of clinical pharmacology 20010401
Co-existing proteins interfere with the action of nordihydroguaiaretic acid on retrograde Golgi-to-ER protein trafficking in NRK cells and alpha-glucosidase reaction in vitro.	Bioscience, biotechnology, and biochemistry 20010401
N-Aminoindoline derivatives as inhibitors of 5-lipoxygenase.	Bioorganic & medicinal chemistry letters 20010326
Arachidonyltrifluoromethy ketone, a phospholipase A(2) antagonist, induces dispersal of both Golgi stack- and trans Golgi network-resident proteins throughout the cytoplasm.	Biochemical and biophysical research communications 20010223
Determination of binding constant of transcription factor AP-1 and DNA. Application of inhibitors.	European journal of biochemistry 20010201
Serum-dependent perinuclear accumulation of Cdc42 in mammalian cells.	Oncology reports 20010101
Systemic and portal hemodynamic effects of anandamide.	American journal of physiology. Gastrointestinal and liver physiology 20010101
Carcinogen substrate specificity of human COX-1 and COX-2.	Carcinogenesis 20010101
Different intracellular signals coupled to the antiproliferative action of aqueous crude extract from Larrea divaricata Cav. and nor-dihydroguaiaretic acid on a lymphoma cell line.	Phytomedicine : international journal of phytotherapy and phytopharmacology 20010101
[Growth inhibition and induction of tumor cell death by phospholipase A2 and lipoxygenase inhibitors].	Izvestiia Akademii nauk. Seriia biologicheskaia 20010101
Protective effect of a lipoxygenase inhibitor, nordihydroguaretic acid, on the ileal motor disturbances induced by Serratia marcescens endotoxin in rats.	Surgery today 20010101
Reduction in primary nonfunction of syngeneic islet transplants with nordihydroguaiaretic acid, a lipoxygenase inhibitor.	Cell transplantation 20010101
Effects of 1alpha,25-(OH)(2)D(3) on rat growth zone chondrocytes are mediated via cyclooxygenase-1 and phospholipase A(2).	Journal of cellular biochemistry. Supplement 20010101
Effect of nordihydroguaiaretic acid on behavioral impairment and neuronal cell death after forebrain ischemia.	Pharmacology, biochemistry, and behavior 20010101
The role of eicosanoids in the process of adaptation following massive bowel resection in the rat.	JPEN. Journal of parenteral and enteral nutrition 20010101
Low-density lipoprotein induced actin cytoskeleton reorganization in endothelial cells: mechanisms of action.	Endothelium : journal of endothelial cell research 20010101
Activation of transcription factors activator protein-1 and nuclear factor-kappaB by 2,3,7,8-tetrachlorodibenzo-p-dioxin.	Biochemical pharmacology 20000415
Involvement of lipoxygenase in lysophosphatidic acid-stimulated hydrogen peroxide release in human HaCaT keratinocytes.	The Biochemical journal 20000315
24R,25-(OH)(2)D(3) mediates its membrane receptor-dependent effects on protein kinase C and alkaline phosphatase via phospholipase A(2) and cyclooxygenase-1 but not cyclooxygenase-2 in growth plate chondrocytes.	Journal of cellular physiology 20000301
Glutathione oxidation and mitochondrial depolarization as mechanisms of nordihydroguaiaretic acid-induced apoptosis in lipoxygenase-deficient FL5.12 cells.	Toxicological sciences : an official journal of the Society of Toxicology 20000101
Prostaglandins and leukotriene B4 are potent inhibitors of 11beta-hydroxysteroid dehydrogenase type 2 activity in human choriocarcinoma JEG-3 cells.	Biology of reproduction 19990701
Nordihydroguaiaretic acid blocks secretory and endocytic pathways in human dendritic cells.	Journal of leukocyte biology 19981201
Crm-A, bcl-2 and NDGA inhibit CD95L-induced apoptosis of malignant glioma cells at the level of caspase 8 processing.	Cell death and differentiation 19981001
Antiviral activities of methylated nordihydroguaiaretic acids. 1. Synthesis, structure identification, and inhibition of tat-regulated HIV transactivation.	Journal of medicinal chemistry 19980730
Antiviral activities of methylated nordihydroguaiaretic acids. 2. Targeting herpes simplex virus replication by the mutation insensitive transcription inhibitor tetra-O-methyl-NDGA.	Journal of medicinal chemistry 19980730
Apoptosis of W256 carcinosarcoma cells of the monocytoid origin induced by NDGA involves lipid peroxidation and depletion of GSH: role of 12-lipoxygenase in regulating tumor cell survival.	Journal of cellular physiology 19970801
Redox regulation of manganese superoxide dismutase.	The American journal of physiology 19960701
Enhancement of stress-induced synthesis of hsp27 and alpha B crystallin by modulators of the arachidonic acid cascade.	Journal of cellular physiology 19960201
Inhibition of human immunodeficiency virus type 1 transcription and replication by DNA sequence-selective plant lignans.	Proceedings of the National Academy of Sciences of the United States of America 19951121
Regulation of prostaglandin H synthase 2 expression in human monocytes by the marine natural products manoalide and scalaradial. Novel effects independent of inhibition of lipid mediator production.	Biochemical pharmacology 19950928
The non-steroidal anti-inflammatory drug, indomethacin, as an inhibitor of HIV replication.	FEBS letters 19950220
Novel bishydroxamic acids as 5-lipoxygenase inhibitors.	Bioorganic & medicinal chemistry 19940301
Some antioxidants inhibit, in a co-ordinate fashion, the production of tumor necrosis factor-alpha, IL-beta, and IL-6 by human peripheral blood mononuclear cells.	International immunology 19940301
Profile of capsaicin-induced mouse ear oedema as neurogenic inflammatory model: comparison with arachidonic acid-induced ear oedema.	British journal of pharmacology 19931201
Effect of indomethacin, aspirin, nordihydroguairetic acid, and piperonyl butoxide on cyclophosphamide-induced bladder damage.	Drug and chemical toxicology 19930101
Pharmacological investigation of the role of leukotrienes in the pathogenesis of experimental NSAID gastropathy.	Inflammation 19920601
Arachidonic acid-induced calcium influx in human platelets. Comparison with the effect of thrombin.	The Biochemical journal 19901201
Inhibition of benzoyl peroxide-mediated tumor promotion in 7,12-dimethylbenz(a)anthracene-initiated skin of Sencar mice by antioxidants nordihydroguaiaretic acid and diallyl sulfide.	The Journal of investigative dermatology 19900201
Metmyoglobin promotes arachidonic acid peroxidation at acid pH.	The Journal of biological chemistry 19890605
Species difference of 5-lipoxygenase derived from polymorphonuclear leukocytes on sensitivity to drugs.	Japanese journal of pharmacology 19890501
Simple procedure for measuring the pharmacodynamics and analgesic potential of lipoxygenase inhibitors.	Journal of pharmacological methods 19881201
In vitro inhibition of leukotriene B4 formation by exogeneous 5-lipoxygenase inhibitors is associated with enhanced generation of 15-hydroxy-eicosatetraenoic acid (15-HETE) by human neutrophils.	Archives of dermatological research 19880101
Prolactin-dependent mitogenesis in Nb 2 node lymphoma cells: effects of immunosuppressive cyclopeptides.	Journal of immunology (Baltimore, Md. : 1950) 19870101
Effects of some non-steroidal anti-inflammatory drugs and other agents on cyclooxygenase and lipoxygenase activities in some enzyme preparations.	Japanese journal of pharmacology 19850601
Comparative effects of etodolac, indomethacin, and benoxaprofen on icosanoid biosynthesis.	Inflammation 19841201
Inhibition of steroid production in Leydig cells by non-steroidal anti-inflammatory and related compounds: evidence for the involvement of lipoxygenase products in steroidogenesis.	The Biochemical journal 19840415
A cystic nephropathy induced by nordihydroguaiaretic acid in the rat. Light and electron microscopic investigations.	Laboratory investigation; a journal of technical methods and pathology 19700701

Rat α-Fetoprotein binding affinities of a large set of structurally diverse chemicals elucidated the relationships between structures and binding affinities.

Chemical research in toxicology 20121119

mTORC1 is a target of nordihydroguaiaretic acid to prevent breast tumor growth in vitro and in vivo.

Breast cancer research and treatment 20121101

Arachidonic acid stimulates DNA synthesis in brown preadipocytes through the activation of protein kinase C and MAPK.

Biochimica et biophysica acta 20121001

Synthesis and SAR studies of 3-allyl-4-prenyloxyaniline amides as potent 15-lipoxygenase inhibitors.

Bioorganic & medicinal chemistry 20120915

Phenolic compound production in relation to differentiation in cell and tissue cultures of Larrea divaricata (Cav.).

Plant science : an international journal of experimental plant biology 20120901

Synthesis of sulfur containing dihydro-pyrrolo derivatives and their biological evaluation as antioxidants.

Bioorganic & medicinal chemistry 20120901

Natural polyphenols as modulators of TTR amyloidogenesis: in vitro and in vivo evidences towards therapy.

Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 20120601

Subepithelial trypsin induces enteric nerve-mediated anion secretion by activating proteinase-activated receptor 1 in the mouse cecum.

The journal of physiological sciences : JPS 20120501

Novel NSAID 1-acyl-4-cycloalkyl/arylsemicarbazides and 1-acyl-5-benzyloxy/hydroxy carbamoylcarbazides as potential anticancer agents and antioxidants.

European journal of medicinal chemistry 20120501

Phase I study of terameprocol in patients with recurrent high-grade glioma.

Neuro-oncology 20120401

Dihydroceramide accumulation and reactive oxygen species are distinct and nonessential events in 4-HPR-mediated leukemia cell death.

Biochemistry and cell biology = Biochimie et biologie cellulaire 20120401

The protective effect of nordihydroguaiaretic acid on cerebral ischemia/reperfusion injury is mediated by the JNK pathway.

Brain research 20120322

The dietary supplementation of nordihydroguaiaretic acid (NDGA) delayed the loss of climbing ability in Drosophila model of Parkinson's disease.

Journal of dietary supplements 20120301

Signaling pathways activated by the phytochemical nordihydroguaiaretic acid contribute to a Keap1-independent regulation of Nrf2 stability: Role of glycogen synthase kinase-3.

Free radical biology & medicine 20120115

Α-aryl-N-alkyl nitrones, as potential agents for stroke treatment: synthesis, theoretical calculations, antioxidant, anti-inflammatory, neuroprotective, and brain-blood barrier permeability properties.

Journal of medicinal chemistry 20120112

A phase II study of insulin-like growth factor receptor inhibition with nordihydroguaiaretic acid in men with non-metastatic hormone-sensitive prostate cancer.

Oncology reports 20120101

Hypoxia promotes rabbit pulmonary artery smooth muscle cells proliferation through a 15-LOX-2 product 15(S)-hydroxyeicosatetraenoic acid.

Prostaglandins, leukotrienes, and essential fatty acids 20120101

Fragment-based design, docking, synthesis, biological evaluation and structure-activity relationships of 2-benzo/benzisothiazolimino-5-aryliden-4-thiazolidinones as cycloxygenase/lipoxygenase inhibitors.

European journal of medicinal chemistry 20120101

Interleukin-1 induction of aggrecanase gene expression in human articular chondrocytes is mediated by mitogen-activated protein kinases.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

Jasmonic acid is involved in the signaling pathway for fungal endophyte-induced volatile oil accumulation of Atractylodes lancea plantlets.

BMC plant biology 20120101

Arachidonic acid and its COX1/2 metabolites inhibit interferon-γ mediated induction of indoleamine-2,3 dioxygenase in THP-1 cells and human monocytes.

Prostaglandins, leukotrienes, and essential fatty acids 20120101

Evaluation of the antioxidative properties of lipoxygenase inhibitors.

Pharmacological reports : PR 20120101

cPLA(2)α gene activation by IL-1β is dependent on an upstream kinase pathway, enzymatic activation and downstream 15-lipoxygenase activity: a positive feedback loop.

Cellular signalling 20111201

Effects of hypolipidemic agent nordihydroguaiaretic acid on lipid droplets and hepatitis C virus.

Hepatology (Baltimore, Md.) 20111201

Synthesis and biological evaluation of (2,5-dihydro-1H-pyrrol-1-yl)-2H-chromen-2-ones as free radical scavengers.

European journal of medicinal chemistry 20111201

Alteration in inflammatory/apoptotic pathway and histone modifications by nordihydroguaiaretic acid prevents acute pancreatitis in swiss albino mice.

Apoptosis : an international journal on programmed cell death 20111101

Design, synthesis and biological evaluation of benzo[1.3.2]dithiazolium ylide 1,1-dioxide derivatives as potential dual cyclooxygenase-2/5-lipoxygenase inhibitors.

Bioorganic & medicinal chemistry 20111101

Bioassay-guided identification of an anti-inflammatory prenylated acylphloroglucinol from Melicope ptelefolia and molecular insights into its interaction with 5-lipoxygenase.

Bioorganic & medicinal chemistry 20111101

Significant biological role of sp1 transactivation in multiple myeloma.

Clinical cancer research : an official journal of the American Association for Cancer Research 20111015

Tumor-associated macrophages mediate immunosuppression in the renal cancer microenvironment by activating the 15-lipoxygenase-2 pathway.

Cancer research 20111015

Effects of transient receptor potential channel blockers on pacemaker activity in interstitial cells of Cajal from mouse small intestine.

Molecules and cells 20110831

The lipogenesis pathway as a cancer target.

Journal of medicinal chemistry 20110825

Thrombin inhibitors with lipid peroxidation and lipoxygenase inhibitory activities.

Bioorganic & medicinal chemistry letters 20110815

Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.

Journal of medicinal chemistry 20110811

Development of Neh2-luciferase reporter and its application for high throughput screening and real-time monitoring of Nrf2 activators.

Chemistry & biology 20110624

An inhibitor of arachidonate 5-lipoxygenase, Nordy, induces differentiation and inhibits self-renewal of glioma stem-like cells.

Stem cell reviews 20110601

Synthesis, in silico docking experiments of new 2-pyrrolidinone derivatives and study of their anti-inflammatory activity.

Bioorganic & medicinal chemistry 20110501

Melittin activates TRPV1 receptors in primary nociceptive sensory neurons via the phospholipase A2 cascade pathways.

Biochemical and biophysical research communications 20110429

Modulation of lipid peroxidation and mitochondrial function improves neuropathology in Huntington's disease mice.

Acta neuropathologica 20110401

ABA controls H₂O₂ accumulation through the induction of OsCATB in rice leaves under water stress.

Plant & cell physiology 20110401

Discovery of a small molecule PDI inhibitor that inhibits reduction of HIV-1 envelope glycoprotein gp120.

ACS chemical biology 20110318

Involvement of H-Ras and reactive oxygen species in proinflammatory cytokine-induced matrix metalloproteinase-13 expression in human articular chondrocytes.

Archives of biochemistry and biophysics 20110315

Role of arachidonic acid lipoxygenase metabolites in acetylcholine-induced relaxations of mouse arteries.

American journal of physiology. Heart and circulatory physiology 20110301

Activated oncogenic pathways and therapeutic targets in extranodal nasal-type NK/T cell lymphoma revealed by gene expression profiling.

The Journal of pathology 20110301

Removal of the toxic effects of chlormadinon acetate on the development of Drosophila melanogaster via the use of nordihydroguaiaretic acid.

Toxicology and industrial health 20110201

Localization of lipoxygenase activity on the oil bodies and in protoplasts using a novel fluorescence imaging method.

Plant physiology and biochemistry : PPB 20110201

Topical anti-inflammatory activity of boropinic acid and its natural and semi-synthetic derivatives.

Bioorganic & medicinal chemistry letters 20110115

The complement component C5a is present in human coronary lesions in vivo and induces the expression of MMP-1 and MMP-9 in human macrophages in vitro.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110101

Adrenocorticotrophic hormone-stimulated cortisol release by the head kidney inter-renal tissue from sea bream (Sparus aurata) fed with linseed oil and soyabean oil.

The British journal of nutrition 20110101

Analysis of nordihydroguaiaretic acid in Larrea divaricata Cav. extracts by micellar electrokinetic chromatography.

Phytochemical analysis : PCA 20110101

Design, synthesis and pharmacobiological evaluation of novel acrylic acid derivatives acting as lipoxygenase and cyclooxygenase-1 inhibitors with antioxidant and anti-inflammatory activities.

European journal of medicinal chemistry 20110101

Terameprocol (tetra-O-methyl nordihydroguaiaretic acid), an inhibitor of Sp1-mediated survivin transcription, induces radiosensitization in non-small cell lung carcinoma.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20110101

Glycosylated nordihydroguaiaretic acids as anti-cancer agents.

Bioorganic & medicinal chemistry letters 20110101

One-pot microwave assisted synthesis under green chemistry conditions, antioxidant screening, and cytotoxicity assessments of benzimidazole Schiff bases and pyrimido[1,2-a]benzimidazol-3(4H)-ones.

European journal of medicinal chemistry 20110101

Inhibitory effect of nordihydroguaiaretic acid on β-catenin/Tcf signalling in β-catenin-activated cells.

Cell biochemistry and function 20110101

Dynein/Dynactin-mediated transport of kinetochore components off kinetochores and onto spindle poles induced by nordihydroguaiaretic acid.

PloS one 20110101

Nordihydroguaiaretic acid (NDGA) inhibits ritonavir-induced endothelial dysfunction in porcine pulmonary arteries.

Medical science monitor : international medical journal of experimental and clinical research 20110101

Anti-inflammatory and redox-protective activities of citronellal.

Biological research 20110101

Life extension by diet restriction and N-acetyl-L-cysteine in genetically heterogeneous mice.

The journals of gerontology. Series A, Biological sciences and medical sciences 20101201

Convenient synthesis and biological profile of 5-amino-substituted 1,2,4-oxadiazole derivatives.

European journal of medicinal chemistry 20101201

Inhibition of poxvirus growth by Terameprocol, a methylated derivative of nordihydroguaiaretic acid.

Antiviral research 20101201

Does conjugation of antioxidants improve their antioxidative/anti-inflammatory potential?

Bioorganic & medicinal chemistry 20101201

Role of leukotriene B4 in celecoxib-mediated anticancer effect.

Biochemical and biophysical research communications 20101112

Hepatoma-derived growth factor promotes the resistance to anti-tumor effects of nordihydroguaiaretic acid in colorectal cancer cells.

European journal of pharmacology 20101025

Nordihydroguaiaretic acid protects against high-fat diet-induced fatty liver by activating AMP-activated protein kinase in obese mice.

Biochemical and biophysical research communications 20101008

Synthesis and biological evaluation of indomethacin analogs possessing a N-difluoromethyl-1,2-dihydropyrid-2-one ring system: a search for novel cyclooxygenase and lipoxygenase inhibitors.

Bioorganic & medicinal chemistry letters 20101001

In vitro growth-inhibitory effect of plant-derived extracts and compounds against Paenibacillus larvae and their acute oral toxicity to adult honey bees.

Veterinary microbiology 20100928

Design, synthesis, and biological evaluation of prenylated chalcones as 5-LOX inhibitors.

Bioorganic & medicinal chemistry 20100815

Structure-activity relationship studies of acridones as potential antipsoriatic agents. 1. Synthesis and antiproliferative activity of simple N-unsubstituted 10H-acridin-9-ones against human keratinocyte growth.

European journal of medicinal chemistry 20100801

Synthesis and biological screening of some novel amidocarbamate derivatives of ketoprofen.

European journal of medicinal chemistry 20100701

A novel synthesis of 3-aryl coumarins and evaluation of their antioxidant and lipoxygenase inhibitory activity.

Bioorganic & medicinal chemistry letters 20100701

Mechanism of the OH radical scavenging activity of nordihydroguaiaretic acid: a combined theoretical and experimental study.

The journal of physical chemistry. B 20100520

Characterization and modulation of canine mast cell derived eicosanoids.

Veterinary immunology and immunopathology 20100515

Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19).

Bioorganic & medicinal chemistry letters 20100515

Molecular mechanisms and clinical applications of nordihydroguaiaretic acid (NDGA) and its derivatives: an update.

Medical science monitor : international medical journal of experimental and clinical research 20100428

[Nordihydroguaiaretic acid partially inhibits inflammatory responses after focal cerebral ischemia in rats].

Sheng li xue bao : [Acta physiologica Sinica] 20100425

[Elucidation of mechanism underlying amyloid-beta peptide aggregation and its neurotoxicity expression and inhibition of these molecular processes by beneficial synthetic and natural compounds with low-molecular weights-new approaches to fundamental treatment and prevention of Alzheimer's disease].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20100401

[Ganglioside cluster-mediated aggregation and cytotoxicity of amyloid beta-peptide: molecular mechanism and inhibition].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20100401

In vitro immunomodulatory effects of fractions obtained from aqueous extracts of Larrea divaricata Cav (Jarilla) on mouse peritoneal macrophages.

Immunopharmacology and immunotoxicology 20100301

Rescue of ER oxidoreductase function through polyphenolic phytochemical intervention: implications for subcellular traffic and neurodegenerative disorders.

Biochemical and biophysical research communications 20100219

A novel porous collagen scaffold around an implantable biosensor for improving biocompatibility. II. Long-term in vitro/in vivo sensitivity characteristics of sensors with NDGA- or GA-crosslinked collagen scaffolds.

Journal of biomedical materials research. Part A 20100201

Crosslinking effect of Nordihydroguaiaretic acid (NDGA) on decellularized heart valve scaffold for tissue engineering.

Journal of materials science. Materials in medicine 20100201

The direct effect of levobupivacaine in isolated rat aorta involves lipoxygenase pathway activation and endothelial nitric oxide release.

Anesthesia and analgesia 20100201

Phenylacetic acid regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.

Bioorganic & medicinal chemistry letters 20100201

ROCK pathway participates in the processes that 15-hydroxyeicosatetraenoic acid (15-HETE) mediated the pulmonary vascular remodeling induced by hypoxia in rat.

Journal of cellular physiology 20100101

Syntheses and evaluation of the antioxidant activity of acitretin analogs with amide bond(s) in the polyene spacer.

European journal of medicinal chemistry 20100101

Inhibitory activity of Brazilian green propolis components and their derivatives on the release of cys-leukotrienes.

Bioorganic & medicinal chemistry 20100101

Oxidative stress in NSC-741909-induced apoptosis of cancer cells.

Journal of translational medicine 20100101

Metabolic engineering of resveratrol and other longevity boosting compounds.

BioFactors (Oxford, England) 20100101

Synthesis and anti-inflammatory evaluation of novel angularly or linearly fused coumarins.

European journal of medicinal chemistry 20091201

A cell-based assay for screening lipoxygenase inhibitors.

Prostaglandins & other lipid mediators 20091201

Natural and synthetic 2'-hydroxy-chalcones and aurones: synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity.

Bioorganic & medicinal chemistry 20091201

Phenolic compounds prevent Alzheimer's pathology through different effects on the amyloid-beta aggregation pathway.

The American journal of pathology 20091201

Assembly of an intact Golgi complex requires phospholipase A2 (PLA2) activity, membrane tubules, and dynein-mediated microtubule transport.

Biochemical and biophysical research communications 20091120

Synthesis of modified homo-N-nucleosides from the reactions of mesityl nitrile oxide with 9-allylpurines and their influence on lipid peroxidation and thrombin inhibition.

Bioorganic & medicinal chemistry letters 20091115

CYP-omega-hydroxylation-dependent metabolites of arachidonic acid inhibit the basolateral 10 pS chloride channel in the rat thick ascending limb.

Kidney international 20091001

Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Nature chemical biology 20091001

Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes.

Journal of natural products 20091001

A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta.

Bioorganic & medicinal chemistry letters 20090901

Nordihydroguaiaretic acid inhibits transforming growth factor beta type 1 receptor activity and downstream signaling.

European journal of pharmacology 20090815

Synthesis, characterization, and anti-melanoma activity of tetra-O-substituted analogs of nordihydroguaiaretic acid.

Bioorganic & medicinal chemistry letters 20090815

Cannabidiol-2',6'-dimethyl ether, a cannabidiol derivative, is a highly potent and selective 15-lipoxygenase inhibitor.

Drug metabolism and disposition: the biological fate of chemicals 20090801

Urea and carbamate derivatives of primaquine: synthesis, cytostatic and antioxidant activities.

Bioorganic & medicinal chemistry 20090801

Reactive oxygen species and lipoxygenases regulate the oncogenicity of NPM-ALK-positive anaplastic large cell lymphomas.

Oncogene 20090723

Synthesis and evaluation of the antioxidant and anti-inflammatory activity of novel coumarin-3-aminoamides and their alpha-lipoic acid adducts.

European journal of medicinal chemistry 20090701

Jasmonic acid is induced in a biphasic manner in response of pea seedlings to wounding.

Journal of integrative plant biology 20090601

Rethinking a drug treatment failure on a traditional ALS target.

Experimental neurology 20090401

5-Lipoxygenase plays a role in the control of parasite burden and contributes to oxidative damage of erythrocytes in murine Chagas' disease.

Immunology letters 20090324

Glucose-induced delay of seed germination in rice is mediated by the suppression of ABA catabolism rather than an enhancement of ABA biosynthesis.

Plant & cell physiology 20090301

Synthesis of hydroxycoumarins and hydroxybenzo[f]- or [h]coumarins as lipid peroxidation inhibitors.

Bioorganic & medicinal chemistry letters 20090215

Hypoxia suppresses KV1.5 channel expression through endogenous 15-HETE in rat pulmonary artery.

Prostaglandins & other lipid mediators 20090101

Identification of xenoestrogens in food additives by an integrated in silico and in vitro approach.

Chemical research in toxicology 20090101

Inhibition of ovulation by a lipoxygenase inhibitor involves reduced cyclooxygenase-2 expression and prostaglandin E2 production in gonadotropin-primed immature rats.

Reproduction (Cambridge, England) 20090101

Post-treatment effects of erythropoietin and nordihydroguaiaretic acid on recovery from cisplatin-induced acute renal failure in the rat.

Journal of Korean medical science 20090101

Effects of celecoxib and nordihydroguaiaretic acid on puromycin aminonucleoside-induced nephrosis in the rat.

Journal of Korean medical science 20090101

The effect of nordihydroguaiaretic acid on iodoacetate-induced toxicity in cultured neurons.

Journal of biochemical and molecular toxicology 20090101

Substance P upregulates LTB4 in rat adherent macrophages from granuloma induced by KMnO4.

Neurotoxicity research 20090101

Nordihydroguaiaretic acid analogues: their chemical synthesis and biological activities.

Current topics in medicinal chemistry 20090101

Chemosensitizing effect of nordihydroguaiaretic acid and its tetra-acetylated derivative on parental and multiresistant TA3 mouse mammary adenocarcinoma cells.

In vivo (Athens, Greece) 20090101

Characterization of novel furan compounds on the basis of their radical scavenging activity and cytoprotective effects against glutamate- and lipopolysaccharide-induced insults.

Bioorganic & medicinal chemistry 20081215

Cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate and nordihydroguaiaretic acid inhibit human Kv1.5 currents independently of lipoxygenase.

European journal of pharmacology 20081214

Nordihydroguaiaretic acid activates the antioxidant pathway Nrf2/HO-1 and protects cerebellar granule neurons against oxidative stress.

Neuroscience letters 20081212

Ethylene and ABA interactions in the regulation of flower induction in Pharbitis nil.

Journal of plant physiology 20081201

Abscisic acid is involved in chitosan-induced resistance to tobacco necrosis virus (TNV).

Plant physiology and biochemistry : PPB 20081201

Overexpression of 5-lipoxygenase in colon polyps and cancer and the effect of 5-LOX inhibitors in vitro and in a murine model.

Clinical cancer research : an official journal of the American Association for Cancer Research 20081015

A novel porous collagen scaffold around an implantable biosensor for improving biocompatibility. I. In vitro/in vivo stability of the scaffold and in vitro sensitivity of the glucose sensor with scaffold.

Journal of biomedical materials research. Part A 20081001

Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice.

Aging cell 20081001

Conjugated linoleic acid-induced fat loss dependence on Delta6-desaturase or cyclooxygenase.

Obesity (Silver Spring, Md.) 20081001

Nordihydroguaiaretic acid inhibits an activated fibroblast growth factor receptor 3 mutant and blocks downstream signaling in multiple myeloma cells.

Cancer research 20080915

Nordihydroguaiaretic acid increases glutamate uptake in vitro and in vivo: therapeutic implications for amyotrophic lateral sclerosis.

Experimental neurology 20080901

Nordihydroguaiaretic acid autoxidation produces a schisandrin-like dibenzocyclooctadiene lignan.

Journal of natural products 20080901

The non-steroidal anti-inflammatory drugs protect mouse cochlea against acoustic injury.

The Tohoku journal of experimental medicine 20080901

Regulation of pro-inflammatory responses by lipoxygenases via intracellular reactive oxygen species in vitro and in vivo.

Experimental & molecular medicine 20080831

Inhibitory effects of nordihydroguaiaretic acid (NDGA) on the IGF-1 receptor and androgen dependent growth of LAPC-4 prostate cancer cells.

The Prostate 20080801

The differentiation-inducing effect of Nordy on HPV-16 subgenes-immortalized human endocervical cells H8.

Anti-cancer drugs 20080801

Synthesis and biological evaluation of 1-(benzenesulfonamido)-2-[5-(N-hydroxypyridin-2(1H)-one)]acetylene regioisomers: a novel class of 5-lipoxygenase inhibitors.

Bioorganic & medicinal chemistry letters 20080715

Sevoflurane and the feto-placental vasculature: the role of nitric oxide and vasoactive eicosanoids.

Anesthesia and analgesia 20080701

Nordihydroguaiaretic acid, a cytotoxic insulin-like growth factor-I receptor/HER2 inhibitor in trastuzumab-resistant breast cancer.

Molecular cancer therapeutics 20080701

Nordihydroguaiaretic acid restores expression of silenced E-cadherin gene in human breast cancer cell lines and xenografts.

Anti-cancer drugs 20080601

Phase I clinical trial of repeat dose terameprocol vaginal ointment in healthy female volunteers.

Sexually transmitted diseases 20080601

[Advances in the research of lipoxygenase inhibitors].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20080601

Future target molecules for influenza treatment.

Mini reviews in medicinal chemistry 20080501

Screening of 397 chemicals and development of a quantitative structure--activity relationship model for androgen receptor antagonism.

Chemical research in toxicology 20080401

New nordihydroguaiaretic acid derivatives as anti-HIV agents.

Bioorganic & medicinal chemistry letters 20080315

Effect of the interaction between lipoxygenase pathway and progesterone on the regulation of hydroxysteroid 11-Beta dehydrogenase 2 in cultured human term placental trophoblasts.

Biology of reproduction 20080301

Nordihydroguaiaretic acid attenuates potassium dichromate-induced oxidative stress and nephrotoxicity.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080301

Terameprocol, a novel site-specific transcription inhibitor with anticancer activity.

IDrugs : the investigational drugs journal 20080301

Nordihydroguaiaretic acid (NDGA), an inhibitor of the HER2 and IGF-1 receptor tyrosine kinases, blocks the growth of HER2-overexpressing human breast cancer cells.

Journal of cellular biochemistry 20080201

Cytosolic phospholipase A2 and arachidonic acid metabolites modulate ventilator-induced permeability increases in isolated mouse lungs.

Journal of applied physiology (Bethesda, Md. : 1985) 20080201

Unique proteomic features induced by a potential antiglioma agent, Nordy (dl-nordihydroguaiaretic acid), in glioma cells.

Proteomics 20080201

A pilot dose-escalation study of the effects of nordihydroguareacetic acid on hormone and prostate specific antigen levels in patients with relapsed prostate cancer.

BJU international 20080201

[Effect of nordy on the function of endothelial progenitor cells from human umbilical cord blood induced by vascular endothelial growth factor].

Yao xue xue bao = Acta pharmaceutica Sinica 20080201

Reactivation of methylation-silenced tumor suppressor gene p16INK4a by nordihydroguaiaretic acid and its implication in G1 cell cycle arrest.

Life sciences 20080130

The flavonoid quercetin regulates growth and gene expression in rat FRTL-5 thyroid cells.

Endocrinology 20080101

RANTES (CCL5) potentiates calcium ionophore in the production of LTB4 in rat adherent macrophages from granuloma induced by KMnO4: inhibiton by NDGA.

Pharmacological research 20080101

Antigenotoxic effect of nordihydroguaiaretic acid against chlormadinone acetate-induced genotoxicity in mice bone-marrow cells.

Journal of natural medicines 20080101

Organic extracts of Larrea divaricata Cav. induced apoptosis on tumoral MCF7 cells with an higher cytotoxicity than nordihydroguaiaretic acid or paclitaxel.

Journal of experimental therapeutics & oncology 20080101

Single-laboratory validated method for determination of nordihydroguaiaretic acid in chaparral-containing dietary supplements.

Journal of AOAC International 20080101

Inhibitory effect of nordihydroguaiaretic acid and its tetra-acetylated derivative on respiration and growth of adenocarcinoma TA3 and its multiresistant variant TA3MTX-R.

In vivo (Athens, Greece) 20080101

Nordihydroguaiaretic acid inhibits insulin-like growth factor signaling, growth, and survival in human neuroblastoma cells.

Journal of cellular biochemistry 20071215

Structure-activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2.

Bioorganic & medicinal chemistry 20071201

Copper-induced peroxidation of phosphatidylserine-containing liposomes is inhibited by nanomolar concentrations of specific antioxidants.

Chemistry and physics of lipids 20071201

Phase I/II clinical safety studies of terameprocol vaginal ointment.

Gynecologic oncology 20071201

Nordihydroguaiaretic acid increases endothelial nitric oxide synthase expression via the transcription factor AP-1.

DNA and cell biology 20071201

Synthesis and anti-inflammatory/antioxidant activities of some new ring substituted 3-phenyl-1-(1,4-di-N-oxide quinoxalin-2-yl)-2-propen-1-one derivatives and of their 4,5-dihydro-(1H)-pyrazole analogues.

Bioorganic & medicinal chemistry letters 20071201

Nordihydroguaiaretic acid induces astroglial death via glutathione depletion.

Journal of neuroscience research 20071101

Inhibition of L-type Ca2+ channel current and negative inotropy induced by arachidonic acid in adult rat ventricular myocytes.

American journal of physiology. Cell physiology 20071101

Inhibitory effect of nordihydroguaiaretic acid, a plant lignan, on Helicobacter pylori-associated gastric carcinogenesis in Mongolian gerbils.

Cancer science 20071101

Penta-acetyl geniposide-induced apoptosis involving transcription of NGF/p75 via MAPK-mediated AP-1 activation in C6 glioma cells.

Toxicology 20070905

A novel lipoxygenase inhibitor Nordy attenuates malignant human glioma cell responses to chemotactic and growth stimulating factors.

Journal of neuro-oncology 20070901

Synthesis and pharmacochemical evaluation of novel aryl-acetic acid inhibitors of lipoxygenase, antioxidants, and anti-inflammatory agents.

Bioorganic & medicinal chemistry 20070901

Lipoxygenase inhibitors induce death receptor 5/TRAIL-R2 expression and sensitize malignant tumor cells to TRAIL-induced apoptosis.

Cancer science 20070901

The anticancer activity of the transcription inhibitor terameprocol (meso-tetra-O-methyl nordihydroguaiaretic acid) formulated for systemic administration.

Anti-cancer drugs 20070901

Oxidation of the lignan nordihydroguaiaretic acid.

Chemical research in toxicology 20070901

[Effect of nordy on biological behaviors of malignant glioma cell line U87MG and the analysis of differential expression proteome].

Zhonghua bing li xue za zhi = Chinese journal of pathology 20070901

Correlation of Golgi localization of ZW10 and centrosomal accumulation of dynactin.

Biochemical and biophysical research communications 20070803

The anti-cancer compound Nordy inhibits CXCR4-mediated production of IL-8 and VEGF by malignant human glioma cells.

Journal of neuro-oncology 20070801

An Aging Interventions Testing Program: study design and interim report.

Aging cell 20070801

Inhibition of IGF-1R and lipoxygenase by nordihydroguaiaretic acid (NDGA) analogs.

Bioorganic & medicinal chemistry letters 20070715

Modification of sericin-free silk fibers for ligament tissue engineering application.

Journal of biomedical materials research. Part B, Applied biomaterials 20070701

A plant lignan, 3'-O-methyl-nordihydroguaiaretic acid, suppresses papillomavirus E6 protein function, stabilizes p53 protein, and induces apoptosis in cervical tumor cells.

Molecular carcinogenesis 20070701

Design and synthesis of novel quinolinone-3-aminoamides and their alpha-lipoic acid adducts as antioxidant and anti-inflammatory agents.

Journal of medicinal chemistry 20070517

Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti.

Journal of natural products 20070501

Regulation of topoisomerase II alpha and beta in HIV-1 infected and uninfected neuroblastoma and astrocytoma cells: involvement of distinct nordihydroguaretic acid sensitive inflammatory pathways.

Archives of biochemistry and biophysics 20070501

Endogenous production of reactive oxygen species is required for stimulation of human articular chondrocyte matrix metalloproteinase production by fibronectin fragments.

Free radical biology & medicine 20070501

Effect of heating on peroxynitrite scavenging capacity of garlic.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20070401

Tetra-O-methyl nordihydroguaiaretic acid inhibits growth and induces death of leukemia cells independent of Cdc2 and survivin.

Leukemia & lymphoma 20070401

Protective role of nordihydroguaiaretic acid (NDGA) against the genotoxic damage induced by ethynodiol diacetate in human lymphocytes in vitro.

Journal of environmental biology 20070401

Assessing 12(S)-lipoxygenase inhibitory activity using colorectal cancer cells overexpressing the enzyme.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20070301

[Effect of nordy on FPR function of malignant human glioma cell line U87].

Yao xue xue bao = Acta pharmaceutica Sinica 20070301

[Nordy inhibits cell proliferation and angiogenic factor production of malignant human glioma cells mediated by formylpeptide receptor].

Zhonghua yi xue za zhi 20070213

Nordihydroguaiaretic acid affects multiple dynein-dynactin functions in interphase and mitotic cells.

Molecular pharmacology 20070201

5-LOX inhibitor modulates the inflammatory responses provoked by Helicobacter pylori infection.

Helicobacter 20070201

Effects of arachidonate metabolism inhibitors on basal and human chorionic gonadotropin-stimulated progesterone secretion by rat corpus luteum cells in vitro.

Prostaglandins & other lipid mediators 20070201

Design and study of some novel ibuprofen derivatives with potential nootropic and neuroprotective properties.

Bioorganic & medicinal chemistry 20070115

Exploiting hypoxia in solid tumors to achieve oncolysis.

Medical hypotheses 20070101

Transport characteristics of a novel local drug delivery system using nordihydroguaiaretic acid (NDGA)-polymerized collagen fibers.

Biotechnology progress 20070101

Effect of hydroalcoholic extract of Zingiber officinalis rhizomes on LPS-induced rat airway hyperreactivity and lung inflammation.

Prostaglandins, leukotrienes, and essential fatty acids 20070101

Effects of inhibitors of the arachidonic acid cascade on primary muscle culture from a Duchenne muscular dystrophy patient.

Prostaglandins, leukotrienes, and essential fatty acids 20070101

Early effects triggered by Larrea divaricata Cav. on murine macrophages at apoptotic concentrations.

Immunopharmacology and immunotoxicology 20070101

Activation and apoptosis of mouse peritoneal macrophages by extracts of Larrea divaricata Cav. (jarilla).

International immunopharmacology 20061220

Enhancing engraftment of neonatal porcine xenoislet with CTLA4Ig and nordihydroguaiaretic acid.

Transplantation proceedings 20061201

Reversal of multidrug resistance by two nordihydroguaiaretic acid derivatives, M4N and maltose-M3N, and their use in combination with doxorubicin or paclitaxel.

Cancer chemotherapy and pharmacology 20061101

Neurotoxicity of lidocaine involves specific activation of the p38 mitogen-activated protein kinase, but not extracellular signal-regulated or c-jun N-terminal kinases, and is mediated by arachidonic acid metabolites.

Anesthesiology 20061101

Prooxidant activity and toxicity of nordihydroguaiaretic acid in clone-9 rat hepatocyte cultures.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20061001

5-Hydroxyeicosatetraenoic acid is a key intermediate of the arachidonate-dependent protective signaling in monocytes/macrophages exposed to peroxynitrite.

Journal of leukocyte biology 20061001

Effects of selective inhibition of cyclooxygenase and lipooxygenase pathways in follicle rupture and ovulation in the rat.

Reproduction (Cambridge, England) 20061001

Effects of hyposmotic stress on exocytosis in isolated turbot, Scophthalmus maximus, hepatocytes.

Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20060901

Oxidative stress-driven mechanisms of nordihydroguaiaretic acid-induced apoptosis in FL5.12 cells.

Toxicology and applied pharmacology 20060801

Survivin-dependent and -independent pathways and the induction of cancer cell death by tetra-O-methyl nordihydroguaiaretic acid.

Seminars in oncology 20060801

Single-cell enzyme concentrations, kinetics, and inhibition analysis using high-density hydrodynamic cell isolation arrays.

Analytical chemistry 20060715

Mechanisms regulating tumor angiogenesis by 12-lipoxygenase in prostate cancer cells.

The Journal of biological chemistry 20060707

The action of extracellular NAD+ on gluconeogenesis in the perfused rat liver.

Molecular and cellular biochemistry 20060601

Nordihydroguaiaretic acid is a potent in vitro scavenger of peroxynitrite, singlet oxygen, hydroxyl radical, superoxide anion and hypochlorous acid and prevents in vivo ozone-induced tyrosine nitration in lungs.

Free radical research 20060501

Nordy, a synthetic lipoxygenase inhibitor, inhibits the expression of formylpeptide receptor and induces differentiation of malignant glioma cells.

Biochemical and biophysical research communications 20060421

Overcoming trastuzumab resistance with nordihydroguaiaretic acid?

Breast cancer research and treatment 20060401

Alpha-lipoic acid exhibits anti-amyloidogenicity for beta-amyloid fibrils in vitro.

Biochemical and biophysical research communications 20060324

Synthesis and structure-activity relationship studies of 1,3-diarylprop-2-yn-1-ones: dual inhibitors of cyclooxygenases and lipoxygenases.

Journal of medicinal chemistry 20060309

Protective effect of nordihydroguaiaretic acid (NDGA) against norgestrel induced genotoxic damage.

Toxicology in vitro : an international journal published in association with BIBRA 20060301

Differential effect of saturated, monounsaturated, and polyunsaturated fatty acids on alloxan-induced diabetes mellitus.

Prostaglandins, leukotrienes, and essential fatty acids 20060301

Schisandrene, a dibenzocyclooctadiene lignan from Schisandra chinensis: structure-antioxidant activity relationships of dibenzocyclooctadiene lignans.

Journal of natural products 20060301

Effects of nordihydroguaiaretic acid on Na+ currents in rat dorsal root ganglion neurons.

Brain research 20060209

Increased angiogenic capabilities of endothelial cells from microvessels of malignant human gliomas.

International immunopharmacology 20060101

Glucose metabolism in isolated uteri of immature rats. Influence of prostaglandins and nitric oxide.

Reproduction, nutrition, development 20060101

Blockade of arachidonic acid pathway induces sprouting in the adult but not in the neonatal uncrossed retinotectal projection.

Neuroscience 20060101

Purification, product characterization and kinetic properties of lipoxygenase from olive fruit (Olea europaea L.).

Plant physiology and biochemistry : PPB 20060101

Eicosanoid-mediated proinflammatory activity of Pseudomonas aeruginosa ExoU.

Cellular microbiology 20051201

Structure-activity relationship of polyphenols that inhibit fatty acid synthase.

Journal of biochemistry 20051201

Nordihydroguaiaretic acid (NDGA) inhibits the IGF-1 and c-erbB2/HER2/neu receptors and suppresses growth in breast cancer cells.

Breast cancer research and treatment 20051101

Synthesis and biological evaluation of 1,3-diphenylprop-2-yn-1-ones as dual inhibitors of cyclooxygenases and lipoxygenases.

Bioorganic & medicinal chemistry letters 20051101

Synthesis and antiinflammatory activity of coumarin derivatives.

Journal of medicinal chemistry 20051006

Role of arachidonic acid in hyposmotic membrane stretch-induced increase in calcium-activated potassium currents in gastric myocytes.

Acta pharmacologica Sinica 20051001

The anti-apoptotic effects of nordihydroguaiaretic acid: inhibition of cPLA(2) activation during TNF-induced apoptosis arises from inhibition of calcium signaling.

Life sciences 20050923

15S-Lipoxygenase-2 mediates arachidonic acid-stimulated adhesion of human breast carcinoma cells through the activation of TAK1, MKK6, and p38 MAPK.

The Journal of biological chemistry 20050909

Conjugated linoleic acid, cis-9,trans-11, is a substrate for pulmonary 15-lipoxygenase-1 in rat.

Journal of agricultural and food chemistry 20050907

Effect of Larrea tridentata (creosote bush) on cholesterol gallstones and bile secretion in hamsters.

The Journal of pharmacy and pharmacology 20050901

5-Lipoxygenase inhibitors attenuate growth of human renal cell carcinoma and induce apoptosis through arachidonic acid pathway.

Oncology reports 20050701

Systemic treatment with tetra-O-methyl nordihydroguaiaretic acid suppresses the growth of human xenograft tumors.

Clinical cancer research : an official journal of the American Association for Cancer Research 20050615

Determination and confirmation of five phenolic antioxidants in foods by LC/MS and GC/MS.

Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20050601

The effects of nitric oxide synthase--versus lipoxygenase inhibition on coronary flow and nitrite outflow in isolated rat heart.

General physiology and biophysics 20050601

Survival prolongation of microencapsulated allogeneic islet by nanosized nordihydroguaiaretic acid.

Transplantation proceedings 20050501

Larrea tridentata (Creosote bush), an abundant plant of Mexican and US-American deserts and its metabolite nordihydroguaiaretic acid.

Journal of ethnopharmacology 20050426

Leukotriene and prostaglandin synthesis pathways in osteoarthritic synovial membranes: regulating factors for interleukin 1beta synthesis.

The Journal of rheumatology 20050401

Nordihydroguaiaretic acid inhibits IFN-gamma-induced STAT tyrosine phosphorylation in rat brain astrocytes.

Biochemical and biophysical research communications 20050311

Nordihydroguaiaretic acid (NDGA) blocks the differentiation of C2C12 myoblast cells.

Journal of cellular physiology 20050301

Tryptamine and homotryptamine-based sulfonamides as potent and selective inhibitors of 15-lipoxygenase.

Bioorganic & medicinal chemistry letters 20050301

CDC2/CDK1 expression in esophageal adenocarcinoma and precursor lesions serves as a diagnostic and cancer progression marker and potential novel drug target.

The American journal of surgical pathology 20050301

Sensitization of colon cancer cell lines to butyrate-mediated proliferation inhibition by combined application of indomethacin and nordihydroguaiaretic acid.

Cancer detection and prevention 20050101

Inhibition of influenza-virus-induced apoptosis in chorion cells of human fetal membranes by nordihydroguaiaretic Acid.

Intervirology 20050101

Anti-inflammatory effects of specific cyclooxygenase 2,5-lipoxygenase, and inducible nitric oxide synthase inhibitors on experimental autoimmune anterior uveitis (EAAU).

Ocular immunology and inflammation 20050101

The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis via induction of 15-lipoxygenase-1 in colorectal cancer cells.

Cancer research 20041201

New acylated iridoid glucosides from Vitex altissima.

Journal of natural products 20041201

Group IIA secretory phospholipase A2 is a unique 12/15-lipoxygenase-regulated gene in cytokine-stimulated rat fibroblastic 3Y1 cells.

Biochimica et biophysica acta 20041108

Anti-amyloidogenic activity of tannic acid and its activity to destabilize Alzheimer's beta-amyloid fibrils in vitro.

Biochimica et biophysica acta 20041105

Suppression of heat- and polyglutamine-induced cytotoxicity by nonsteroidal anti-inflammatory drugs.

European journal of biochemistry 20041101

Arachidonic acid regulation of steroid synthesis: new partners in the signaling pathway of steroidogenic hormones.

Endocrine research 20041101

Multiple contributions from long-chain fatty acid metabolism in Y-1 and MA-10 cells.

Endocrine research 20041101

The arachidonic acid 5-lipoxygenase inhibitor nordihydroguaiaretic acid inhibits tumor necrosis factor alpha activation of microglia and extends survival of G93A-SOD1 transgenic mice.

Journal of neurochemistry 20041001

Nordihydroguaiaretic acid-induced Ca2+ handling and cytotoxicity in human prostate cancer cells.

Life sciences 20040924

Lignoids in insects: chemical probes for the study of ecdysis, excretion and Trypanosoma cruzi-triatomine interactions.

Toxicon : official journal of the International Society on Toxinology 20040915

Nordihydroguairetic acid, a lignin, prevents oxidative stress and the development of diabetic nephropathy in rats.

Pharmacology 20040901

Nordihydroguaiaretic acid does not disaggregate beta-amyloid(1-40) protofibrils but does inhibit growth arising from direct protofibril association.

Molecular pharmacology 20040901

Stimulatory actions of caffeic acid phenethyl ester, a known inhibitor of NF-kappaB activation, on Ca2+-activated K+ current in pituitary GH3 cells.

The Journal of biological chemistry 20040625

A new lead compound for abscisic acid biosynthesis inhibitors targeting 9-cis-epoxycarotenoid dioxygenase.

Bioorganic & medicinal chemistry letters 20040621

Prostaglandin F(2alpha) is protective for apoptosis stimulated synergistically with 12-O-tetradecanoyl phorbol-beta-acetate and nordihydroguaiaretic acid in Madin-Darby canine kidney cells.

Biochimica et biophysica acta 20040601

Effect of Larrea divaricata Cav. extract and nordihydroguaiaretic acid upon peroxidase secretion in rat submandibulary glands.

Pharmacological research 20040501

Inhibitors of 5-lipoxygenase inhibit expression of intercellular adhesion molecule-1 in human melanoma cells.

Acta pharmacologica Sinica 20040501

BK2 but not BK1 receptors mediating contractile response in human umbilical arteries: role of thromboxane A2.

Methods and findings in experimental and clinical pharmacology 20040501

Involvement of spinal lipoxygenase metabolites in hyperalgesia and opioid tolerance.

European journal of pharmacology 20040426

Substance P can stimulate prostaglandin D2 and leukotriene C4 generation without granule exocytosis in murine mast cells.

European journal of pharmacology 20040405

Interleukin-17 signal transduction pathways implicated in inducing matrix metalloproteinase-3, -13 and aggrecanase-1 genes in articular chondrocytes.

Cellular signalling 20040401

Inhibition of AP-1 transcription activator induces myc-dependent apoptosis in HL60 cells.

Journal of cellular biochemistry 20040401

A stepwise dissection of the intracellular fate of cationic cell-penetrating peptides.

The Journal of biological chemistry 20040326

Curcumin has potent anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro.

Journal of neuroscience research 20040315

Adipocyte differentiation of multipotent cells established from human adipose tissue.

Biochemical and biophysical research communications 20040305

Determination of binding constant of transcription factor myc-max/max-max and E-box DNA: the effect of inhibitors on the binding.

Biochimica et biophysica acta 20040224

The effects of TNF-alpha and inhibitors of arachidonic acid metabolism on human colon HT-29 cells depend on differentiation status.

Differentiation; research in biological diversity 20040201

TGSA-Flex: Extending the capabilities of the Topo-Geometrical Superposition Algorithm to handle flexible molecules.

Journal of computational chemistry 20040130

Estrogenic activity of an antioxidant, nordihydroguaiaretic acid (NDGA).

Life sciences 20040130

Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake.

The Journal of biological chemistry 20040109

Tetrapetalone A, a novel lipoxygenase inhibitor from Streptomyces sp.

Bioscience, biotechnology, and biochemistry 20040101

Effects of eicosanoid biosynthesis inhibitors on the prophenoloxidase-activating system and microaggregation reactions in the hemolymph of Rhodnius prolixus infected with Trypanosoma rangeli.

Journal of insect physiology 20040101

15-LOX-1 inhibits p21 (Cip/WAF 1) expression by enhancing MEK-ERK 1/2 signaling in colon carcinoma cells.

Prostaglandins & other lipid mediators 20040101

Inhibitory action of ICI-182,780, an estrogen receptor antagonist, on BK(Ca) channel activity in cultured endothelial cells of human coronary artery.

Biochemical pharmacology 20031115

Dihydrolipoic acid inhibits 15-lipoxygenase-dependent lipid peroxidation.

Free radical biology & medicine 20031115

Lipoxygenase inhibitors enhance tumor suppressive effects of jun proteins on v-myb-transformed monoblasts BM2.

Prostaglandins & other lipid mediators 20031101

Adipocyte differentiation of 3T3-L1 preadipocytes is dependent on lipoxygenase activity during the initial stages of the differentiation process.

The Biochemical journal 20031101

Naturally occurring lignans efficiently induce apoptosis in colorectal tumor cells.

Journal of cancer research and clinical oncology 20031001

Nordihydroguaiaretic acid, an antioxidant, inhibits transforming growth factor-beta activity through the inhibition of Smad signaling pathway.

Experimental cell research 20031001

Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor.

Chemical research in toxicology 20031001

The role of oxidant-mediated pathways in the cytotoxicity of endothelial cells exposed to mesenteric lymph from rats subjected to trauma-hemorrhagic shock.

Shock (Augusta, Ga.) 20030901

Spinal administration of lipoxygenase inhibitors suppresses behavioural and neurochemical manifestations of naloxone-precipitated opioid withdrawal.

British journal of pharmacology 20030901

Nitric oxide triggers the toxicity due to glutathione depletion in midbrain cultures through 12-lipoxygenase.

The Journal of biological chemistry 20030613

Roles of 5-lipoxygenase activating protein in cell proliferation and apoptosis.

Cell biology and toxicology 20030601

Neuroprotection by the endogenous cannabinoid anandamide and arvanil against in vivo excitotoxicity in the rat: role of vanilloid receptors and lipoxygenases.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20030515

Fatty acid release and oxidation are factors in lipoxygenase inhibitor-induced apoptosis.

Toxicology letters 20030303

Mechanical and thermal properties of novel polymerized NDGA-gelatin hydrogels.

Biomaterials 20030301

Inhibition of HSV-1 replication and reactivation by the mutation-insensitive transcription inhibitor tetra-O-glycyl-nordihydroguaiaretic acid.

Antiviral research 20030301

Novel antiviral agent tetraglycylated nordihydroguaiaretic acid hydrochloride as a host-dependent viral inhibitor.

Antiviral research 20030301

Oxidant-stimulated chloride secretion in rat jejunum in vitro is mediated by eicosanoids.

Digestive diseases and sciences 20030301

Direct interaction of the Golgi membrane with the endoplasmic reticulum membrane caused by nordihydroguaiaretic acid.

Biochemical and biophysical research communications 20030221

Inhibition by eicosapentaenoic acid of IL-1beta-induced PGHS-2 expression in human microvascular endothelial cells: involvement of lipoxygenase-derived metabolites and p38 MAPK pathway.

Biochimica et biophysica acta 20030220

Abnormalities in intracellular Ca2+ regulation in fetal vascular smooth muscle in pre-eclampsia: enhanced sensitivity to arachidonic acid.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030201

Contribution of 5- and 12-lipoxygenase products to mechanical hyperalgesia induced by prostaglandin E(2) and epinephrine in the rat.

Experimental brain research 20030201

Lipoxygenase products regulate nitric oxide and inducible nitric oxide synthase production in interleukin-1beta stimulated vascular smooth muscle cells.

Hypertension research : official journal of the Japanese Society of Hypertension 20030201

Mepanipyrim, a novel inhibitor of pharmacologically induced Golgi dispersion.

Bioscience, biotechnology, and biochemistry 20030101

Nordihydroguaiaretic acid, of a new family of microtubule-stabilizing agents, shows effects differentiated from paclitaxel.

Bioscience, biotechnology, and biochemistry 20030101

Eicosanoid precursor polyenoic fatty acids modulate synaptic levels of dopamine in ex-vivo slices of rat brain striatum.

In vivo (Athens, Greece) 20030101

[Effect of inhibitors of cyclooxygenase and lypoxygenase pathway of metabolism of arachidonic acid on the development and suppression of the immune response in mice].

Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20030101

Lipoxygenase inhibitors suppress proliferation of G5:113 fibrosarcoma cells in vitro but they have no anticancer activity in vivo.

Neoplasma 20030101

Prostaglandin F2alpha protected cultured Madin-Darby canine kidney cells from the development of apoptosis induced by 12-o-tetradecanoyl phorbol-beta-acetate and stimulated synergistically with nordihydroguaiaretic acid.

Advances in experimental medicine and biology 20030101

BAD and Bcl-2 regulation are early events linking neuronal endoplasmic reticulum stress to mitochondria-mediated apoptosis.

Brain research. Molecular brain research 20021230

Nordihydroguaiaretic acid: hepatotoxicity and detoxification in the mouse.

Toxicon : official journal of the International Society on Toxinology 20021201

Aberrant arachidonic acid metabolism in esophageal adenocarcinogenesis, and the effects of sulindac, nordihydroguaiaretic acid, and alpha-difluoromethylornithine on tumorigenesis in a rat surgical model.

Carcinogenesis 20021201

Concerted regulation of free arachidonic acid and hormone-induced steroid synthesis by acyl-CoA thioesterases and acyl-CoA synthetases in adrenal cells.

European journal of biochemistry 20021101

ACTH regulation of mitochondrial acyl-CoA thioesterase activity in Y1 adrenocortical tumour cells.

Endocrine research 20021101

Effect of nordihydroguaiaretic acid on intracellular Ca(2+) concentrations in hepatocytes.

Toxicology in vitro : an international journal published in association with BIBRA 20021001

Effect of nordihydroguaiaretic acid on the secretion of lipoprotein lipase.

Journal of biochemistry and molecular biology 20020930

Inhibition of peroxisome proliferator-activated receptor (PPAR)-mediated keratinocyte differentiation by lipoxygenase inhibitors.

The Biochemical journal 20020915

Design, synthesis, and biological evaluation of a cephalosporin-monohydroguaiaretic acid prodrug activated by a monoclonal antibody-beta-lactamase conjugate.

Bioorganic & medicinal chemistry 20020901

N-acylethanolamines are metabolized by lipoxygenase and amidohydrolase in competing pathways during cottonseed imbibition.

Plant physiology 20020901

Neurons overexpressing mutant presenilin-1 are more sensitive to apoptosis induced by endoplasmic reticulum-Golgi stress.

Journal of neuroscience research 20020815

Structure-activity relationship studies of nordihydroguaiaretic acid inhibitors toward soybean, 12-human, and 15-human lipoxygenase.

Journal of medicinal chemistry 20020606

Induction of MnSOD gene by arachidonic acid is mediated by reactive oxygen species and p38 MAPK signaling pathway in human HepG2 hepatoma cells.

Free radical biology & medicine 20020601

Participation of the arachidonic acid cascade pathway in macrophage binding/uptake of oxidized low density lipoprotein.

Biological & pharmaceutical bulletin 20020601

Nordihydroguaiaretic acid-mediated inhibition of ultraviolet B-induced activator protein-1 activation in human keratinocytes.

Molecular carcinogenesis 20020601

Effects of brefeldin A and nordihydroguaiaretic acid on endomembrane dynamics and lipid synthesis in plant cells.

FEBS letters 20020508

Effects of cyclooxygenase and lipoxygenase inhibition on basal- and serotonin-induced ion transport in rat colon.

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20020501

Involvement of glycogen synthase kinase-3beta and tau phosphorylation in neuronal Golgi disassembly.

Journal of neurochemistry 20020501

Nordihydroguaiaretic acid potently breaks down pre-formed Alzheimer's beta-amyloid fibrils in vitro.

Journal of neurochemistry 20020501

Mechanisms underlying the activation of large conductance Ca2+-activated K+ channels by nordihydroguaiaretic acid.

Japanese journal of pharmacology 20020501

Mechanisms of nordihydroguaiaretic acid-induced growth inhibition and apoptosis in human cancer cells.

British journal of cancer 20020408

[Simultaneous determination of five antioxidants in food by HPLC with fluorescence detection].

Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20020401

Comparative quantitative structure toxicity relationships for flavonoids evaluated in isolated rat hepatocytes and HeLa tumor cells.

Chemico-biological interactions 20020320

Effect of nordihydroguaiaretic acid on intracellular Ca(2+) concentrations in C6 glioma cells.

Neurochemistry international 20020301

Possible implication of Golgi-nucleating function for the centrosome.

Biochemical and biophysical research communications 20020301

Expression and induction of the stress protein alpha-B-crystallin in vascular endothelial cells.

Histochemistry and cell biology 20020301

Effects of inhibitors of the lipo-oxygenase family of enzymes on the store-operated calcium current I(CRAC) in rat basophilic leukaemia cells.

The Journal of physiology 20020215

Tending tender tendons.

Science (New York, N.Y.) 20020208

5-Lipoxygenase and human pulmonary artery endothelial cell proliferation.

American journal of physiology. Heart and circulatory physiology 20020201

Differential effect of brefeldin A on the palmitoylation of surfactant protein C proprotein mutants.

Biochemical and biophysical research communications 20020111

The lipoxygenase pathways are involved in LH-stimulated progesterone production in bovine corpus luteum.

Prostaglandins & other lipid mediators 20020101

Cytosolic phospholipase A2 and lipoxygenase are involved in cell cycle progression in neuroblastoma cells.

Cellular and molecular life sciences : CMLS 20020101

[Effect of exogenous leukotrienes and lipoxygenase inhibitors on apoptosis and necrosis in cultured rat hepatocytes].

Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20020101

[Lipoxygenase inhibitors induce rat hepatocyte apoptosis in primary culture].

Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20020101

Regulation of apoptosis through arachidonate cascade in mammalian cells.

Applied biochemistry and biotechnology 20020101

Lipoxygenase inhibitors induce arrest of tumor cells in S-phase of the cell cycle.

Neoplasma 20020101

Progressive apoptosis in chorion laeve trophoblast cells of human fetal membrane tissues during in vitro incubation is suppressed by antioxidative reagents.

European journal of biochemistry 20011201

Nordihydroguaiaretic acid elevates osteoblastic intracellular Ca2+.

Pharmacology & toxicology 20011201

Synthesis and anticancer activity of nordihydroguaiaretic acid (NDGA) and analogues.

Anti-cancer drug design 20011201

Lipoxygenase inhibitors inhibit heparin-releasable lipoprotein lipase activity in 3T3-L1 adipocytes and enhance body fat reduction in mice by conjugated linoleic acid.

Biochimica et biophysica acta 20011130

5-lipoxygenase regulates malignant mesothelial cell survival: involvement of vascular endothelial growth factor.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20011101

Intracellular signaling pathway of FGF-2-modulated corneal endothelial cell migration during wound healing in vitro.

Experimental eye research 20011101

Eicosanoids participate in the regulation of cardiac glucose transport by contribution to a rearrangement of actin cytoskeletal elements.

The Biochemical journal 20011001

Histamine stimulates alveolar macrophages to release neutrophil and monocyte chemotactic activity.

The Journal of laboratory and clinical medicine 20011001

tetra-O-methylnordihydroguaiaretic acid inhibits melanoma in vivo.

Cancer letters 20010928

trans-10,cis-12-Conjugated linoleic acid reduces leptin secretion from 3T3-L1 adipocytes.

Biochemical and biophysical research communications 20010921

Differential role of cytosolic phospholipase A2 in the invasion of brain microvascular endothelial cells by Escherichia coli and Listeria monocytogenes.

The Journal of infectious diseases 20010915

Elevating dietary salt exacerbates hyperpnea-induced airway obstruction in guinea pigs.

Journal of applied physiology (Bethesda, Md. : 1985) 20010901

Pharmacological modulation of allergic inflammation in the rat airways and association with mast cell heterogeneity.

European journal of pharmacology 20010824

Johns Hopkins embroiled in fresh misconduct allegations.

Nature 20010802

Characterization of clofibrate-induced retrograde Golgi membrane movement to the endoplasmic reticulum: clofibrate distinguishes the Golgi from the trans Golgi network.

Bioscience, biotechnology, and biochemistry 20010801

Baicalein protects cortical neurons from beta-amyloid (25-35) induced toxicity.

Neuroreport 20010720

Tetra-O-methyl nordihydroguaiaretic acid induces G2 arrest in mammalian cells and exhibits tumoricidal activity in vivo.

Cancer research 20010715

Inhibitors of arachidonic acid metabolism potentiate tumour necrosis factor-alpha-induced apoptosis in HL-60 cells.

European journal of pharmacology 20010713

Biocompatibility of NDGA-polymerized collagen fibers. I. Evaluation of cytotoxicity with tendon fibroblasts in vitro.

Journal of biomedical materials research 20010701

Biocompatibility of NDGA-polymerized collagen fibers. II. Attachment, proliferation, and migration of tendon fibroblasts in vitro.

Journal of biomedical materials research 20010701

Activation of cardiac afferents by arachidonic acid: relative contributions of metabolic pathways.

American journal of physiology. Heart and circulatory physiology 20010701

Glucosylceramide synthesis inhibitors block pharmacologically induced dispersal of the Golgi and anterograde membrane flow from the endoplasmic reticulum: implication of sphingolipid metabolism in maintenance of the Golgi architecture and anterograde membrane flow.

Bioscience, biotechnology, and biochemistry 20010601

Disparate effects of similar phenolic phytochemicals as inhibitors of oxidative damage to cellular DNA.

Mutation research 20010510

Mechanisms of cytokine-induced death of cultured bovine luteal cells.

Reproduction (Cambridge, England) 20010501

Pharmacokinetic analysis by high-performance liquid chromatography of intravenous nordihydroguaiaretic acid in the mouse.

Journal of chromatography. B, Biomedical sciences and applications 20010415

Modulation of the immediate allergic wheal reaction in the skin by drugs inhibiting the effects of leukotriene C4 and prostaglandin D2.

European journal of clinical pharmacology 20010401

Co-existing proteins interfere with the action of nordihydroguaiaretic acid on retrograde Golgi-to-ER protein trafficking in NRK cells and alpha-glucosidase reaction in vitro.

Bioscience, biotechnology, and biochemistry 20010401

N-Aminoindoline derivatives as inhibitors of 5-lipoxygenase.

Bioorganic & medicinal chemistry letters 20010326

Arachidonyltrifluoromethy ketone, a phospholipase A(2) antagonist, induces dispersal of both Golgi stack- and trans Golgi network-resident proteins throughout the cytoplasm.

Biochemical and biophysical research communications 20010223

Determination of binding constant of transcription factor AP-1 and DNA. Application of inhibitors.

European journal of biochemistry 20010201

Serum-dependent perinuclear accumulation of Cdc42 in mammalian cells.

Oncology reports 20010101

Systemic and portal hemodynamic effects of anandamide.

American journal of physiology. Gastrointestinal and liver physiology 20010101

Carcinogen substrate specificity of human COX-1 and COX-2.

Carcinogenesis 20010101

Different intracellular signals coupled to the antiproliferative action of aqueous crude extract from Larrea divaricata Cav. and nor-dihydroguaiaretic acid on a lymphoma cell line.

Phytomedicine : international journal of phytotherapy and phytopharmacology 20010101

[Growth inhibition and induction of tumor cell death by phospholipase A2 and lipoxygenase inhibitors].

Izvestiia Akademii nauk. Seriia biologicheskaia 20010101

Protective effect of a lipoxygenase inhibitor, nordihydroguaretic acid, on the ileal motor disturbances induced by Serratia marcescens endotoxin in rats.

Surgery today 20010101

Reduction in primary nonfunction of syngeneic islet transplants with nordihydroguaiaretic acid, a lipoxygenase inhibitor.

Cell transplantation 20010101

Effects of 1alpha,25-(OH)(2)D(3) on rat growth zone chondrocytes are mediated via cyclooxygenase-1 and phospholipase A(2).

Journal of cellular biochemistry. Supplement 20010101

Effect of nordihydroguaiaretic acid on behavioral impairment and neuronal cell death after forebrain ischemia.

Pharmacology, biochemistry, and behavior 20010101

The role of eicosanoids in the process of adaptation following massive bowel resection in the rat.

JPEN. Journal of parenteral and enteral nutrition 20010101

Low-density lipoprotein induced actin cytoskeleton reorganization in endothelial cells: mechanisms of action.

Endothelium : journal of endothelial cell research 20010101

Activation of transcription factors activator protein-1 and nuclear factor-kappaB by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Biochemical pharmacology 20000415

Involvement of lipoxygenase in lysophosphatidic acid-stimulated hydrogen peroxide release in human HaCaT keratinocytes.

The Biochemical journal 20000315

24R,25-(OH)(2)D(3) mediates its membrane receptor-dependent effects on protein kinase C and alkaline phosphatase via phospholipase A(2) and cyclooxygenase-1 but not cyclooxygenase-2 in growth plate chondrocytes.

Journal of cellular physiology 20000301

Glutathione oxidation and mitochondrial depolarization as mechanisms of nordihydroguaiaretic acid-induced apoptosis in lipoxygenase-deficient FL5.12 cells.

Toxicological sciences : an official journal of the Society of Toxicology 20000101

Prostaglandins and leukotriene B4 are potent inhibitors of 11beta-hydroxysteroid dehydrogenase type 2 activity in human choriocarcinoma JEG-3 cells.

Biology of reproduction 19990701

Nordihydroguaiaretic acid blocks secretory and endocytic pathways in human dendritic cells.

Journal of leukocyte biology 19981201

Crm-A, bcl-2 and NDGA inhibit CD95L-induced apoptosis of malignant glioma cells at the level of caspase 8 processing.

Cell death and differentiation 19981001

Antiviral activities of methylated nordihydroguaiaretic acids. 1. Synthesis, structure identification, and inhibition of tat-regulated HIV transactivation.

Journal of medicinal chemistry 19980730

Antiviral activities of methylated nordihydroguaiaretic acids. 2. Targeting herpes simplex virus replication by the mutation insensitive transcription inhibitor tetra-O-methyl-NDGA.

Journal of medicinal chemistry 19980730

Apoptosis of W256 carcinosarcoma cells of the monocytoid origin induced by NDGA involves lipid peroxidation and depletion of GSH: role of 12-lipoxygenase in regulating tumor cell survival.

Journal of cellular physiology 19970801

Redox regulation of manganese superoxide dismutase.

The American journal of physiology 19960701

Enhancement of stress-induced synthesis of hsp27 and alpha B crystallin by modulators of the arachidonic acid cascade.

Journal of cellular physiology 19960201

Inhibition of human immunodeficiency virus type 1 transcription and replication by DNA sequence-selective plant lignans.

Proceedings of the National Academy of Sciences of the United States of America 19951121

Regulation of prostaglandin H synthase 2 expression in human monocytes by the marine natural products manoalide and scalaradial. Novel effects independent of inhibition of lipid mediator production.

Biochemical pharmacology 19950928

The non-steroidal anti-inflammatory drug, indomethacin, as an inhibitor of HIV replication.

FEBS letters 19950220

Novel bishydroxamic acids as 5-lipoxygenase inhibitors.

Bioorganic & medicinal chemistry 19940301

Some antioxidants inhibit, in a co-ordinate fashion, the production of tumor necrosis factor-alpha, IL-beta, and IL-6 by human peripheral blood mononuclear cells.

International immunology 19940301

Profile of capsaicin-induced mouse ear oedema as neurogenic inflammatory model: comparison with arachidonic acid-induced ear oedema.

British journal of pharmacology 19931201

Effect of indomethacin, aspirin, nordihydroguairetic acid, and piperonyl butoxide on cyclophosphamide-induced bladder damage.

Drug and chemical toxicology 19930101

Pharmacological investigation of the role of leukotrienes in the pathogenesis of experimental NSAID gastropathy.

Inflammation 19920601

Arachidonic acid-induced calcium influx in human platelets. Comparison with the effect of thrombin.

The Biochemical journal 19901201

Inhibition of benzoyl peroxide-mediated tumor promotion in 7,12-dimethylbenz(a)anthracene-initiated skin of Sencar mice by antioxidants nordihydroguaiaretic acid and diallyl sulfide.

The Journal of investigative dermatology 19900201

Metmyoglobin promotes arachidonic acid peroxidation at acid pH.

The Journal of biological chemistry 19890605

Species difference of 5-lipoxygenase derived from polymorphonuclear leukocytes on sensitivity to drugs.

Japanese journal of pharmacology 19890501

Simple procedure for measuring the pharmacodynamics and analgesic potential of lipoxygenase inhibitors.

Journal of pharmacological methods 19881201

In vitro inhibition of leukotriene B4 formation by exogeneous 5-lipoxygenase inhibitors is associated with enhanced generation of 15-hydroxy-eicosatetraenoic acid (15-HETE) by human neutrophils.

Archives of dermatological research 19880101

Prolactin-dependent mitogenesis in Nb 2 node lymphoma cells: effects of immunosuppressive cyclopeptides.

Journal of immunology (Baltimore, Md. : 1950) 19870101

Effects of some non-steroidal anti-inflammatory drugs and other agents on cyclooxygenase and lipoxygenase activities in some enzyme preparations.

Japanese journal of pharmacology 19850601

Comparative effects of etodolac, indomethacin, and benoxaprofen on icosanoid biosynthesis.

Inflammation 19841201

Inhibition of steroid production in Leydig cells by non-steroidal anti-inflammatory and related compounds: evidence for the involvement of lipoxygenase products in steroidogenesis.

The Biochemical journal 19840415

A cystic nephropathy induced by nordihydroguaiaretic acid in the rat. Light and electron microscopic investigations.

Laboratory investigation; a journal of technical methods and pathology 19700701