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50-59-9

50-59-9 | Cephaloridine

CAS No: 50-59-9 Catalog No: AG00DCDH MDL No:

Product Description

Catalog Number:
AG00DCDH
Chemical Name:
Cephaloridine
CAS Number:
50-59-9
IUPAC Name:
(6R,7R)-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
InChI:
InChI=1S/C19H17N3O4S2/c23-14(9-13-5-4-8-27-13)20-15-17(24)22-16(19(25)26)12(11-28-18(15)22)10-21-6-2-1-3-7-21/h1-8,15,18H,9-11H2,(H-,20,23,25,26)/t15-,18-/m1/s1
InChI Key:
CZTQZXZIADLWOZ-CRAIPNDOSA-N
EC Number:
200-052-6
UNII:
LVZ1VC61HB

Properties

Complexity:
687  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
0
Exact Mass:
415.066g/mol
Formal Charge:
0
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
415.482g/mol
Monoisotopic Mass:
415.066g/mol
Rotatable Bond Count:
5  
Topological Polar Surface Area:
147A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.9  

Literature

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Carnitine/organic cation transporter OCTN2 (Slc22a5) is responsible for renal secretion of cephaloridine in mice. Drug metabolism and disposition: the biological fate of chemicals 20090501
L-Carnitine suppresses oleic acid-induced membrane permeability transition of mitochondria. Cell biochemistry and function 20081001
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Serum thymic factor, FTS, attenuates cisplatin nephrotoxicity by suppressing cisplatin-induced ERK activation. Biochemical pharmacology 20051101
The growth rate of Mycobacterium smegmatis depends on sufficient porin-mediated influx of nutrients. Molecular microbiology 20051101
Protective effect of serum thymic factor, FTS, on cephaloridine-induced nephrotoxicity in rats. Biological & pharmaceutical bulletin 20051101
Identification of novel targets of cephaloridine in rabbit renal proximal tubules synthesizing glutamine from alanine. Archives of toxicology 20051001
Human organic anion transporter hOAT3 is a potent transporter of cephalosporin antibiotics, in comparison with hOAT1. Biochemical pharmacology 20051001
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Protective effect of a protein kinase inhibitor on cellular injury induced by cephaloridine in the porcine kidney cell line LLC-PK(1). The Journal of toxicological sciences 20050801
Cephaloridine induces translocation of protein kinase C delta into mitochondria and enhances mitochondrial generation of free radicals in the kidney cortex of rats causing renal dysfunction. Journal of pharmacological sciences 20050501
Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20050101
Protective effect of resveratrol against 6-hydroxydopamine-induced impairment of renal p-aminohippurate transport. Archives of toxicology 20040901
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Intramolecular general acid catalysis in the aminolysis of beta-lactam antibiotics. Organic & biomolecular chemistry 20040307
Involvement of MEK/ERK pathway in cephaloridine-induced injury in rat renal cortical slices. Toxicology letters 20030720
Interaction of human and rat organic anion transporter 2 with various cephalosporin antibiotics. European journal of pharmacology 20030328
Mitochondrial cytochrome c oxidase as a target site for cephalosporin antibiotics in renal epithelial cells (LLC-PK(1)) and renal cortex. Life sciences 20021122
beta-Lactam allergenic determinants: fine structural recognition of a cross-reacting determinant on benzylpenicillin and cephalothin. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20021101
Enhancement of protein kinase C activity and chemiluminescence intensity in mitochondria isolated from the kidney cortex of rats treated with cephaloridine. Biochemical pharmacology 20020801
Interaction of human organic anion transporters with various cephalosporin antibiotics. European journal of pharmacology 20020308
Involvement of rat organic anion transporter 3 (rOAT3) in cephaloridine-induced nephrotoxicity: in comparison with rOAT1. Life sciences 20020308
Performance of Pseudomonas CFC-selective medium in the fish storage ecosystems. Journal of microbiological methods 20011101
Roles of long chain fatty acids and carnitine in mitochondrial membrane permeability transition. Biochemical pharmacology 20011015
Calorimetric analysis of cephalosporins using an immobilized TEM-1 beta-lactamase on Ni2+ chelating sepharose fast flow. Analytical biochemistry 20010901
Independent organic cation transport activity of Na(+)-L-carnitine cotransport system in LLC-PK(1) cells. American journal of physiology. Renal physiology 20010801
Allergy to two drugs in a patient. Allergy 20010801
MspA provides the main hydrophilic pathway through the cell wall of Mycobacterium smegmatis. Molecular microbiology 20010401
Structures of the acyl-enzyme complexes of the Staphylococcus aureus beta-lactamase mutant Glu166Asp:Asn170Gln with benzylpenicillin and cephaloridine. Biochemistry 20010227
Modulation by cyclic AMP and phorbol myristate acetate of cephaloridine-induced injury in rat renal cortical slices. Japanese journal of pharmacology 20010101
Roles of oxygen radical production and lipid peroxidation in the cytotoxicity of cephaloridine on cultured renal epithelial cells (LLC-PK1). The Journal of veterinary medical science 20000901
beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter. The Journal of biological chemistry 20000121
Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity. Kidney international 19991201
Effect of ginsenoside-Rd in cephaloridine-induced renal disorder. Nephron 19990201
Magnesium lithospermate B ameliorates cephaloridine-induced renal injury. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 19971201
[Studies on the mechanisms of renal damages induced by nephrotoxic compounds]. Nihon hoigaku zasshi = The Japanese journal of legal medicine 19951201
Can penicillins and other beta-lactam antibiotics be used to treat tuberculosis? Antimicrobial agents and chemotherapy 19951201
Suppressed expression of calcium-binding protein regucalcin mRNA in the renal cortex of rats with chemically induced kidney damage. Molecular and cellular biochemistry 19951004
Glucocorticoid amelioration of nephrotoxicity: a study of cephaloridine-methylprednisolone interaction in the rat. Human & experimental toxicology 19950701
Cephaloridine nephrotoxicity in diabetic rats: modulation by insulin treatment. Toxicology 19950626
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[Study on gamma-GTP activity in urine and renal tissue of drug-induced nephrotoxicity in rats]. Nihon Hinyokika Gakkai zasshi. The japanese journal of urology 19930701
Cephaloridine nephrotoxicity is potentiated by selenium deficiency but not copper deficiency in rats. The Journal of nutrition 19920601
Methimazole protection of rats against chemically induced kidney damage in vivo. The Journal of pharmacology and experimental therapeutics 19920101
Drugs as allergens: an immunoassay for detecting IgE antibodies to cephalosporins. International archives of allergy and applied immunology 19900101
Safety evaluation of meropenem in animals: studies on the kidney. The Journal of antimicrobial chemotherapy 19890901
Relieving effect of saline on cephaloridine nephrotoxicity in rats. Chemical & pharmaceutical bulletin 19890301
Oxidative and mitochondrial toxic effects of cephalosporin antibiotics in the kidney. A comparative study of cephaloridine and cephaloglycin. Biochemical pharmacology 19890301
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The use of renal cortical slices from the Fischer 344 rat as an in vitro model to evaluate nephrotoxicity. Fundamental and applied toxicology : official journal of the Society of Toxicology 19880701
[Nephrotoxicity of cefodizime sodium in rats--single and 14-day repeated intravenous administration]. The Journal of toxicological sciences 19880601
Protective effect of piperacillin against nephrotoxicity of cephaloridine and gentamicin in animals. Antimicrobial agents and chemotherapy 19880601
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Vasopressin-resistant polyuria induced by cephaloridine administration in rats. Developments in toxicology and environmental science 19860101
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Renal and hepatic necrosis after metabolic activation of 2-substituted furans and thiophenes, including furosemide and cephaloridine. Toxicology and applied pharmacology 19771101
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