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50-44-2

50-44-2 | 6-Mercaptopurine

CAS No: 50-44-2 Catalog No: AG0038PH MDL No:MFCD18074515

Product Description

Catalog Number:
AG0038PH
Chemical Name:
6-Mercaptopurine
CAS Number:
50-44-2
Molecular Formula:
C5H4N4S
Molecular Weight:
152.1771
MDL Number:
MFCD18074515
IUPAC Name:
3,7-dihydropurine-6-thione
InChI:
InChI=1S/C5H4N4S/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)
InChI Key:
GLVAUDGFNGKCSF-UHFFFAOYSA-N
SMILES:
Sc1ncnc2c1[nH]cn2
EC Number:
200-037-4
UNII:
PKK6MUZ20G

Properties

Complexity:
190  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
152.016g/mol
Formal Charge:
0
Heavy Atom Count:
10  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
152.175g/mol
Monoisotopic Mass:
152.016g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
85.2A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
0

Literature

Title Journal
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Why are most phospholipidosis inducers also hERG blockers? Archives of toxicology 20171201
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HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants. Nature genetics 20141001
A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia. Nature genetics 20140901
Genetic polymorphisms in candidate genes predict increased toxicity with methotrexate therapy in Lebanese children with acute lymphoblastic leukemia. Pharmacogenetics and genomics 20140801
Identification of potent Yes1 kinase inhibitors using a library screening approach. Bioorganic & medicinal chemistry letters 20130801
Microarray analysis of 6-mercaptopurine-induced-toxicity-related genes and microRNAs in the rat placenta. The Journal of toxicological sciences 20130201
Fabrication of biodegradable micelles with reduction-triggered release of 6-mercaptopurine profile based on disulfide-linked graft copolymer conjugate. Colloids and surfaces. B, Biointerfaces 20121201
Antibiotic susceptibility profile of Mycobacterium avium subspecies hominissuis is altered in low-iron conditions. The Journal of antimicrobial chemotherapy 20121201
S-allyl derivatives of 6-mercaptopurine are highly potent drugs against human B-CLL through synergism between 6-mercaptopurine and allicin. Leukemia research 20121201
The investigation of the binding of 6-mercaptopurine to site I on human serum albumin. The protein journal 20121201
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Pregnancy outcome after paternal exposure to azathioprine/6-mercaptopurine. Reproductive toxicology (Elmsford, N.Y.) 20121101
PACSIN2 polymorphism influences TPMT activity and mercaptopurine-related gastrointestinal toxicity. Human molecular genetics 20121101
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Central nervous system lesions due to juvenile myelomonocytic leukemia progressed in a boy undergoing first line chemotherapy. International journal of hematology 20120501
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Mucosal healing for predicting clinical outcome in patients with ulcerative colitis using thiopurines in monotherapy. European journal of internal medicine 20111201
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Synthesis of pro-prodrugs L-lysine based for 5-aminosalicylic acid and 6-mercaptopurine colon specific release. International journal of pharmaceutics 20111128
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Rheumatoid arthritis and pregnancy: evolution of disease activity and pathophysiological considerations for drug use. Rheumatology (Oxford, England) 20111101
The transfer of 6-mercaptopurine in the dually perfused human placenta. Reproductive toxicology (Elmsford, N.Y.) 20111101
Evaluating the use of metabolite measurement in children receiving treatment with a thiopurine. Alimentary pharmacology & therapeutics 20111101
Hepatosplenic T-cell lymphoma in patients receiving TNF-α inhibitor therapy: expanding the groups at risk. European journal of gastroenterology & hepatology 20111101
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6-Mercaptopurine: an effective drug in the management of advanced cutaneous T-cell lymphoma. Cutis 20111101
Optimizing 6-mercaptopurine and azathioprine therapy in the management of inflammatory bowel disease. World journal of gastroenterology 20111007
Thiopurine S-methyltransferase (TPMT) polymorphisms in children with acute lymphoblastic leukemia, and the need for reduction or cessation of 6-mercaptopurine doses during maintenance therapy: the Polish multicenter analysis. Pediatric blood & cancer 20111001
Augmented therapy improves outcome for pediatric high risk acute lymphocytic leukemia: results of Children's Oncology Group trial P9906. Pediatric blood & cancer 20111001
Individually tailored treatment of medication nonadherence. Journal of pediatric gastroenterology and nutrition 20111001
A cross-sectional investigation of chronic exposure to microcystin in relationship to childhood liver damage in the Three Gorges Reservoir Region, China. Environmental health perspectives 20111001
Update on the management of ulcerative colitis. Current gastroenterology reports 20111001
Mesenchymal stromal cell function is not affected by drugs used in the treatment of inflammatory bowel disease. Cytotherapy 20111001
Individualized toxicity-titrated 6-mercaptopurine increments during high-dose methotrexate consolidation treatment of lower risk childhood acute lymphoblastic leukaemia. A Nordic Society of Paediatric Haematology and Oncology (NOPHO) pilot study. British journal of haematology 20111001
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Diagnosis and treatment of fistulising Crohn's disease. Danish medical bulletin 20111001
Splenic littoral cell hemangioendothelioma in a patient with Crohn's disease previously treated with immunomodulators and anti-TNF agents: a rare tumor linked to deep immunosuppression. The American journal of gastroenterology 20111001
Nucleobase transport by human equilibrative nucleoside transporter 1 (hENT1). The Journal of biological chemistry 20110916
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Predicting selective drug targets in cancer through metabolic networks. Molecular systems biology 20110101
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Infliximab to treat Crohn's disease: an update. Clinical and experimental gastroenterology 20110101
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A thiopurine drug inhibits West Nile virus production in cell culture, but not in mice. PloS one 20110101
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Novel formulation of a methotrexate derivative with a lipid nanoemulsion. International journal of nanomedicine 20110101
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Mechanisms of neurotoxicity induced in the developing brain of mice and rats by DNA-damaging chemicals. The Journal of toxicological sciences 20110101
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Clinical features and treatment outcome of acute promyelocytic leukemia patients treated at cairo national cancer institute in egypt. Mediterranean journal of hematology and infectious diseases 20110101
Emerging role of rasburicase in the management of increased plasma uric acid levels in patients with hematologic malignancies. Journal of blood medicine 20110101
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Gold nanoparticles in biology and medicine: recent advances and prospects. Acta naturae 20110101
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Combination biological and surgical therapy in an adolescent presenting with highly destructive perianal Crohn disease. Journal of pediatric gastroenterology and nutrition 20101201
A single-center experience with methotrexate after thiopurine therapy in pediatric Crohn disease. Journal of pediatric gastroenterology and nutrition 20101201
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals 20101201
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Modeling mechanisms of in vivo variability in methotrexate accumulation and folate pathway inhibition in acute lymphoblastic leukemia cells. PLoS computational biology 20101201
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Cancer pharmacogenomics and pharmacoepidemiology: setting a research agenda to accelerate translation. Journal of the National Cancer Institute 20101117
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The inflammatory bowel diseases and ambient air pollution: a novel association. The American journal of gastroenterology 20101101
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Activating BRAF mutations in eruptive melanocytic naevi. The British journal of dermatology 20101101
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. Bioorganic & medicinal chemistry letters 20101101
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A prospective evaluation of the impact of allopurinol in pediatric and adult IBD patients with preferential metabolism of 6-mercaptopurine to 6-methylmercaptopurine. Journal of Crohn's & colitis 20101101
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Long-term efficacy of adalimumab in paediatric Crohn's disease patients naïve to other anti-TNF therapies. Journal of Crohn's & colitis 20101101
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The multidrug-resistance protein 4 polymorphism is a new factor accounting for thiopurine sensitivity in Japanese patients with inflammatory bowel disease. Journal of gastroenterology 20101001
Treatment of relapsing mild-to-moderate ulcerative colitis with the probiotic VSL#3 as adjunctive to a standard pharmaceutical treatment: a double-blind, randomized, placebo-controlled study. The American journal of gastroenterology 20101001
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Allopurinol salvage therapy in pediatric overlap autoimmune hepatitis-primary sclerosing cholangitis with 6-MMP toxicity. Journal of pediatric gastroenterology and nutrition 20101001
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Renal cell carcinoma and acute promyelocytic leukemia: a nonrandom association? American journal of hematology 20101001
Combination of the histone deacetylase inhibitor valproic acid with oral hydroxyurea or 6-mercaptopurin can be safe and effective in patients with advanced acute myeloid leukaemia--a report of five cases. Hematology (Amsterdam, Netherlands) 20101001
Monitoring 6-thioguanine nucleotide concentrations in Japanese children and adolescents with inflammatory bowel disease. Journal of gastroenterology and hepatology 20101001
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Pyridoxine treatment of vincristine-induced cranial polyneuropathy in an adult patient with acute lymphocytic leukemia: Case report and review of the literature. Leukemia research 20100801
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Dexamethasone in the maintenance phase of acute lymphoblastic leukaemia treatment: is the risk of lethal infections too high? European journal of cancer (Oxford, England : 1990) 20071101
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Medical management of mild to moderate Crohn's disease: evidence-based treatment algorithms for induction and maintenance of remission. Alimentary pharmacology & therapeutics 20071001
[Common errors in the management of outpatients with inflammatory bowel disease]. Gastroenterologia y hepatologia 20071001
A critical analysis of barriers to the clinical implementation of pharmacogenomics. Therapeutics and clinical risk management 20071001
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Adverse reaction caused by excipients in mercaptopurine tablets. The Annals of pharmacotherapy 20070901
Phase II study of chemotherapy and stem cell transplantation for adult acute lymphoblastic leukemia or lymphoblastic lymphoma: Japan Clinical Oncology Group Study 9004. Cancer science 20070901
Sequential evaluation of thiopurine methyltransferase, inosine triphosphate pyrophosphatase, and HPRT1 genes polymorphisms to explain thiopurines' toxicity and efficacy. Alimentary pharmacology & therapeutics 20070901
Oral tacrolimus for steroid-dependent and steroid-resistant ulcerative colitis in children. Journal of pediatric gastroenterology and nutrition 20070901
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Relevance of pharmacogenetic aspects of mercaptopurine metabolism in the treatment of interstitial lung disease. Current opinion in pulmonary medicine 20070901
Translation of pharmacogenetic knowledge into cancer therapeutics. Clinical advances in hematology & oncology : H&O 20070901
The management of hemophilia in elderly patients. Clinical interventions in aging 20070901
Antimetabolite therapy for lesser-risk B-lineage acute lymphoblastic leukemia of childhood: a report from Children's Oncology Group Study P9201. Blood 20070815
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The efficiency of a PAMAM dendrimer toward the encapsulation of the antileukemic drug 6-mercaptopurine. Anti-cancer drugs 20070801
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A triangulation study of the clinician and patient experiences of the use of the immunosuppressant drugs azathioprine and 6-mercaptopurine for the management of inflammatory bowel disease. Journal of clinical nursing 20070801
Severe pulmonary toxicity after azathioprine/6-mercaptopurine initiation for the treatment of inflammatory bowel disease. Journal of clinical gastroenterology 20070801
Pharmacogenomics in drug-metabolizing enzymes catalyzing anticancer drugs for personalized cancer chemotherapy. Current drug metabolism 20070801
Translating pharmacogenomics: challenges on the road to the clinic. PLoS medicine 20070801
In vitro study of 6-mercaptopurine oxidation catalysed by aldehyde oxidase and xanthine oxidase. Drug metabolism and pharmacokinetics 20070801
The nucleoside and nucleotide mixture (OG-VI) rescues intestinal-like epithelial cells from the cytotoxicity of chemotherapeutic agents. The journal of medical investigation : JMI 20070801
Solid-phase extraction and spectrophotometric determination of mercury with 6-mercaptopurine in environmental samples. Annali di chimica 20070801
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Development of ulcerative colitis in a patient with multiple sclerosis following treatment with interferon beta 1a. World journal of gastroenterology 20070714
Thiopurine-induced liver injury in patients with inflammatory bowel disease: a systematic review. The American journal of gastroenterology 20070701
Therapeutic drug use in women with Crohn's disease and birth outcomes: a Danish nationwide cohort study. The American journal of gastroenterology 20070701
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The rate of hepatitis B and C virus infections and the importance of HBV vaccination in children with acute lymphoblastic leukemia. Hepatology research : the official journal of the Japan Society of Hepatology 20070701
Immune response to influenza vaccine in pediatric patients with inflammatory bowel disease. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20070701
Medical therapy and birth outcomes in women with Crohn's disease: what should we tell our patients? The American journal of gastroenterology 20070701
Disseminated intravascular coagulation in acute leukemia at presentation and during induction therapy. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20070701
Leupeptin inhibits ventilator-induced diaphragm dysfunction in rats. American journal of respiratory and critical care medicine 20070601
Pneumocystis jiroveci (carinii) pneumonia after infliximab therapy: a review of 84 cases. Digestive diseases and sciences 20070601
Human glutathione transferases catalyzing the bioactivation of anticancer thiopurine prodrugs. Biochemical pharmacology 20070601
Management of steroid-dependent ulcerative colitis: immunomodulatory agents, biologics, or surgery? Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20070601
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[Current status of inflammatory bowel disease treatment]. Revista clinica espanola 20070601
Erythema nodosum-like eruption as a manifestation of azathioprine hypersensitivity in patients with inflammatory bowel disease. Archives of dermatology 20070601
Evaluation of renal function in Turkish children receiving BFM-95 therapy for acute lymphoblastic leukemia. Pediatric hematology and oncology 20070601
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6-Mercaptopurine, an activator of Nur77, enhances transcriptional activity of HIF-1alpha resulting in new vessel formation. Oncogene 20070531
What can we learn from geographical comparisons of childhood cancer survival? British journal of cancer 20070521
Differential effects of targeted disruption of thiopurine methyltransferase on mercaptopurine and thioguanine pharmacodynamics. Cancer research 20070515
Reinduction of relapsed acute promyelocytic leukemia with ATRA and low dose antimetabolite-based chemotherapy. Pediatric blood & cancer 20070501
Studies of interactions among cobalt(III) polypyridyl complexes, 6-mercaptopurine and DNA. Bioelectrochemistry (Amsterdam, Netherlands) 20070501
Application of HPLC to study the kinetics of a branched bi-enzyme system consisting of hypoxanthine-guanine phosphoribosyltransferase and xanthine oxidase--an important biochemical system to evaluate the efficiency of the anticancer drug 6-mercaptopurine in ALL cell line. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070501
Thiopurine methyltransferase activity in Spain: a study of 14,545 patients. Digestive diseases and sciences 20070501
Assessment of thiopurine methyltransferase enzyme activity is superior to genotype in predicting myelosuppression following azathioprine therapy in patients with inflammatory bowel disease. Alimentary pharmacology & therapeutics 20070501
Management of inflammatory bowel disease in adults. Journal of digestive diseases 20070501
Thiopurine metabolite monitoring in paediatric inflammatory bowel disease. Alimentary pharmacology & therapeutics 20070415
Synthesis and biological evaluation of some 6-substituted purines. European journal of medicinal chemistry 20070401
Relationship between 6-mercaptopurine dose and 6-thioguanine nucleotide levels in patients with inflammatory bowel disease. Inflammatory bowel diseases 20070401
Azathioprine and breastfeeding: is it safe? BJOG : an international journal of obstetrics and gynaecology 20070401
Comment: Breast-feeding during maternal use of azathioprine. The Annals of pharmacotherapy 20070401
Risk of fecal diversion in complicated perianal Crohn's disease. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20070401
Impact of FLT3 internal tandem duplications on Indian acute promyelocytic leukemia patients: prognostic implications. Hematology (Amsterdam, Netherlands) 20070401
Anticancer nucleobase analogues 6-mercaptopurine and 6-thioguanine are novel substrates for equilibrative nucleoside transporter 2. International journal of pharmaceutics 20070321
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Autologous transplantation of CD133 selected hematopoietic progenitor cells for treatment of relapsed acute lymphoblastic leukemia. Pediatric blood & cancer 20070301
Adolescents with acute lymphoblastic leukaemia: outcome on UK national paediatric (ALL97) and adult (UKALLXII/E2993) trials. Pediatric blood & cancer 20070301
Improved outcome in childhood acute myeloid leukemia in Singapore with the MRC AML 10 protocol. Pediatric blood & cancer 20070301
Should ileoanal pouch surgery be staged for patients with mucosal ulcerative colitis on immunosuppressives? International journal of colorectal disease 20070301
Novel DNA lesions generated by the interaction between therapeutic thiopurines and UVA light. DNA repair 20070301
Synthesis and antiproliferative properties of N3/8-disubstituted 3,8-diazabicyclo[3.2.1]octane analogues of 3,8-bis[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl-piperazine. European journal of medicinal chemistry 20070301
[Combination therapy with low-dose cyclosporin A, azathiopurine, and prednisolone for a child with refractory chronic idiopathic thrombocytopenic purpura]. [Rinsho ketsueki] The Japanese journal of clinical hematology 20070301
6-mercaptopurine (6-MP) entrapped stealth liposomes for improvement of leukemic treatment without hepatotoxicity and nephrotoxicity. Cancer investigation 20070301
Almost normal cognitive function in patients during therapy for childhood acute lymphoblastic leukemia without cranial irradiation according to ALL-BFM 95 and COALL 06-97 protocols: results of an Austrian-German multicenter longitudinal study and implications for follow-up. Pediatric hematology and oncology 20070301
Targeting nanomedicines in the treatment of Crohn's disease: focus on certolizumab pegol (CDP870). International journal of nanomedicine 20070301
Isolated pulmonary Langerhans cell histiocytosis presenting with recurrent pneumothorax. Pediatric blood & cancer 20070201
Cytotoxic effects of histone deacetylase inhibitor FK228 (depsipeptide, formally named FR901228) in combination with conventional anti-leukemia/lymphoma agents against human leukemia/lymphoma cell lines. Investigational new drugs 20070201
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20070201
Efficient screening method of the thiopurine methyltransferase polymorphisms for patients considering taking thiopurine drugs in a Chinese Han population in Henan Province (central China). Clinica chimica acta; international journal of clinical chemistry 20070201
Results of the PETHEMA ALL-96 trial in elderly patients with Philadelphia chromosome-negative acute lymphoblastic leukemia. European journal of haematology 20070201
Medium-term results of oral tacrolimus treatment in refractory inflammatory bowel disease. Inflammatory bowel diseases 20070201
Pharmacogenomics in cancer treatment defining genetic bases for inter-individual differences in responses to chemotherapy. Current opinion in pediatrics 20070201
Nonadherence with thiopurine immunomodulator and mesalamine medications in children with Crohn disease. Journal of pediatric gastroenterology and nutrition 20070201
A nudge in the right direction: shaping the metabolic fate of thiopurines for therapeutic gain. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20070201
Effect of allopurinol on clinical outcomes in inflammatory bowel disease nonresponders to azathioprine or 6-mercaptopurine. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20070201
Crohn's disease of the esophagus. Current treatment options in gastroenterology 20070201
Monitoring of thiopurine methyltransferase activity in postsurgical patients with Crohn's disease during 1 year of treatment with azathioprine or mesalazine. Therapeutic drug monitoring 20070201
Analysis of ITPA phenotype-genotype correlation in the Bulgarian population revealed a novel gene variant in exon 6. Therapeutic drug monitoring 20070201
Nature and position of functional group on thiopurine substrates influence activity of xanthine oxidase--enzymatic reaction pathways of 6-mercaptopurine and 2-mercaptopurine are different. Biochemistry. Biokhimiia 20070201
Activation of nuclear receptor Nur77 by 6-mercaptopurine protects against neointima formation. Circulation 20070130
Azathioprine and 6-mercaptopurine for maintenance of remission in ulcerative colitis. The Cochrane database of systematic reviews 20070124
Prognostic role of the reduced folate carrier, the major membrane transporter for methotrexate, in childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group. Clinical cancer research : an official journal of the American Association for Cancer Research 20070115
Pulses of vincristine and dexamethasone in addition to intensive chemotherapy for children with intermediate-risk acute lymphoblastic leukaemia: a multicentre randomised trial. Lancet (London, England) 20070113
Targeting the cerebrovascular large neutral amino acid transporter (LAT1) isoform using a novel disulfide-based brain drug delivery system. Drug delivery 20070101
Radiation-induced meningioma following prophylactic radiotherapy for acute lymphoblastic leukemia in childhood. Pediatric neurosurgery 20070101
Meta-analysis of risk of malignancy with immunosuppressive drugs in inflammatory bowel disease. The Annals of pharmacotherapy 20070101
Glutathione-S-transferase genotypes and the adverse effects of azathioprine in young patients with inflammatory bowel disease. Inflammatory bowel diseases 20070101
Pouch outcomes among children with ulcerative colitis treated with calcineurin inhibitors before ileal pouch anal anastomosis surgery. Journal of pediatric surgery 20070101
Birth outcome in women treated with azathioprine or mercaptopurine during pregnancy: A Danish nationwide cohort study. Alimentary pharmacology & therapeutics 20070101
[Case of severe ulcerative colitis successfully treated with intravenous cyclosporine without high dose corticosteroid]. Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 20070101
Steroid treatment for severe acute cryptogenic hepatitis. Zeitschrift fur Gastroenterologie 20070101
On the action of methotrexate and 6-mercaptopurine on M. avium subspecies paratuberculosis. PloS one 20070101
Individualized drug therapy. Current opinion in drug discovery & development 20070101
Inflammatory bowel disease: past, present, and future. Journal of gastroenterology 20070101
Thiopurine treatment in inflammatory bowel disease: clinical pharmacology and implication of pharmacogenetically guided dosing. Clinical pharmacokinetics 20070101
Gastroparesis in patients with inactive Crohn's disease: a case series. BMC gastroenterology 20070101
Rasburicase represents a new tool for hyperuricemia in tumor lysis syndrome and in gout. International journal of medical sciences 20070101
Impact of pharmacogenomics on clinical practice in oncology. Molecular diagnosis & therapy 20070101
Genetic tests for predicting the toxicity and efficacy of anticancer chemotherapy. Neoplasma 20070101
Eruptive post-chemotherapy in situ melanomas and dysplastic nevi. Pediatric dermatology 20070101
Adolescent adherence to oral therapy for leukemia: a focus group study. Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses 20070101
[Influence of antitumor preparations on the concentration of free radicals in cells of Fusarium bulbigenum var. blasticola fungus during primary and tumour-like secondary growth]. Biofizika 20070101
Resolution of disseminated fusariosis in a child with acute leukemia treated with combined antifungal therapy: a case report. BMC infectious diseases 20070101
Preferential inhibition of xanthine oxidase by 2-amino-6-hydroxy-8-mercaptopurine and 2-amino-6-purine thiol. BMC biochemistry 20070101
Daunorubicin-induced cell kill with 1-hour versus 24-hour infusions: a randomized comparison in children with newly diagnosed acute lymphoblastic leukemia. Klinische Padiatrie 20070101
The patient with persistent perianal fistulae. Best practice & research. Clinical gastroenterology 20070101
On the action of 5-amino-salicylic acid and sulfapyridine on M. avium including subspecies paratuberculosis. PloS one 20070101
[Modified BFM-90 regimen greatly improves treatment outcomes of chinese childhood and adolescent lymphoblastic lymphoma]. Zhonghua zhong liu za zhi [Chinese journal of oncology] 20070101
Fludarabine, treosulfan and etoposide sensitivity and the outcome of hematopoietic stem cell transplantation in childhood acute myeloid leukemia. Anticancer research 20070101
[Comparison of the present and previously used protocol of risk stratification in children with acute lymphoblastic leukemia]. Medycyna wieku rozwojowego 20070101
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Infliximab therapy in children and adolescents with inflammatory bowel disease. Drugs 20070101
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[The results of a multicenter trial of acute lymphoblastic leukemia treatment on ALL-MB 91/ALL-BFM 90m in children: analysis of efficacy and toxicity]. Terapevticheskii arkhiv 20070101
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[Combination of purine analogues and aminosalicylates in patients with inflammatory bowel disease: why and how?]. Gastroenterologie clinique et biologique 20070101
[Clinical manifestation of hepatotoxic effect of cytostatic chemicals]. Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20070101
Azathioprine: a guide for the management of dermatology patients. Dermatologic therapy 20070101
Myasthenia gravis. Orphanet journal of rare diseases 20070101
Morphine in children with cancer: impact of age, chemotherapy and other factors on protein binding. Journal of pain & palliative care pharmacotherapy 20070101
Acute lymphoblastic leukemia in a patient with chronic cyanoacrylate exposure. Acta haematologica 20070101
Azathioprine in dermatology. Acta dermatovenerologica Croatica : ADC 20070101
Maintenance of medically induced remission of Crohn's disease. Digestion 20070101
Maintenance of surgically induced remission of Crohn's disease. Digestion 20070101
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Survival analysis. Methods in molecular biology (Clifton, N.J.) 20070101
Infliximab: the evidence for its place in therapy in ulcerative colitis. Core evidence 20070101
Certolizumab pegol: an evidence-based review of its place in the treatment of Crohn's disease. Core evidence 20070101
Refractory ulcerative colitis treatment. Gastroenterology & hepatology 20070101
Body mass index does not influence pharmacokinetics or outcome of treatment in children with acute lymphoblastic leukemia. Blood 20061215
Lead compounds for antimalarial chemotherapy: purine base analogs discriminate between human and P. falciparum 6-oxopurine phosphoribosyltransferases. Journal of medicinal chemistry 20061214
Authenticity and drug resistance in a panel of acute lymphoblastic leukaemia cell lines. British journal of cancer 20061204
In vivo comparison of various polymeric and low molecular mass inhibitors of intestinal P-glycoprotein. Biomaterials 20061201
Avascular necrosis--an antineoplastic-treatment-related toxicity: the experiences of two institutions. Pediatric hematology and oncology 20061201
Insights in immunomodulatory therapies for ulcerative colitis and Crohn's disease. Current gastroenterology reports 20061201
Adding pharmacogenetics information to drug labels: lessons learned. Pharmacogenetics and genomics 20061201
Infliximab in ulcerative colitis. Gastroenterology clinics of North America 20061201
Breast-feeding during maternal use of azathioprine. The Annals of pharmacotherapy 20061201
Analysis of thiopurine S-methyltransferase polymorphism in the population of Serbia and Montenegro and mercaptopurine therapy tolerance in childhood acute lymphoblastic leukemia. Therapeutic drug monitoring 20061201
Childhood CD4+/CD56+ hematodermic neoplasm: case report and review of the literature. Haematologica 20061201
Favourable outcome in an APL patient with PLZF/RARalpha fusion gene: quantitative real-time RT-PCR confirms molecular response. Haematologica 20061201
Review article: Medical therapy for fistulizing Crohn's disease. Alimentary pharmacology & therapeutics 20061101
[Monitoring of thiopurine methyltransferase and thiopurine metabolites to optimize azathioprine therapy in inflammatory bowel disease]. Gastroenterologia y hepatologia 20061101
[Risk of postoperative infection in patients with inflammatory bowel disease]. The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 20061101
Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) treated with 2-chlorodeoxyadenosine. Pediatric blood & cancer 20061015
Thioguanine versus mercaptopurine in childhood ALL. Lancet (London, England) 20061014
Toxicity and efficacy of 6-thioguanine versus 6-mercaptopurine in childhood lymphoblastic leukaemia: a randomised trial. Lancet (London, England) 20061014
Pharmacogenetics during standardised initiation of thiopurine treatment in inflammatory bowel disease. Gut 20061001
Utility of thiopurine methyltransferase genotyping and phenotyping, and measurement of azathioprine metabolites in the management of patients with autoimmune hepatitis. Journal of hepatology 20061001
Decreased activity of clotting factor V during ALL consolidation treatment with mercaptopurine in a child. The Annals of pharmacotherapy 20061001
Review article: can post-operative recurrence in Crohn's disease be prevented? Alimentary pharmacology & therapeutics 20061001
Review article: the effect of aminosalicylates and immunomodulation on cancer risk in inflammatory bowel disease. Alimentary pharmacology & therapeutics 20061001
Azathioprine as a postoperative prophylaxis reduces symptoms in aggressive Crohn's disease. Scandinavian journal of gastroenterology 20061001
Exposure to thiopurine drugs through breast milk is low based on metabolite concentrations in mother-infant pairs. British journal of clinical pharmacology 20061001
Leukocytapheresis in patients with moderate-severe steroid-dependant ulcerative colitis: clinical response without endoscopic response. Inflammatory bowel diseases 20061001
The thiopurine methyltransferase genetic polymorphism is associated with thioguanine-related veno-occlusive disease of the liver in children with acute lymphoblastic leukemia. Clinical pharmacology and therapeutics 20061001
Treatment of acute myeloid leukemia patients aged more than 75 years: results of the E-AML-01 trial of the Japanese Elderly Leukemia and Lymphoma Study Group (JELLSG). Leukemia & lymphoma 20061001
[Postoperative recurrence in Crohn's disease. Risk factors and methods of prevention]. La Tunisie medicale 20061001
[The clinical features of B cell lymphoblastic lymphoma and outcomes after BFM-90 regimen therapy]. Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20061001
Molecular mechanisms underlying the enhanced sensitivity of thiopurine-resistant T-lymphoblastic cell lines to methyl mercaptopurineriboside. Biochemical pharmacology 20060928
A synthetic route to 9-(polyhydroxyalkyl)purines. Carbohydrate research 20060925
Assembling of dimeric entities of Cd(II) with 6-mercaptopurine to afford one-dimensional coordination polymers: synthesis and scanning probe microscopy characterization. Inorganic chemistry 20060918
Oral outpatient chemotherapy medication errors in children with acute lymphoblastic leukemia. Cancer 20060915
Stabilization of gold nanoparticles by 6-mercaptopurine monolayers. Effects of the solvent properties. The journal of physical chemistry. B 20060914
Symptomatic hypoglycemia: an unusual side effect of oral purine analogues for treatment of ALL. Pediatric blood & cancer 20060901
Reduction in bioavailability of 6-mercaptopurine on simultaneous administration with cow's milk. Pediatric hematology and oncology 20060901
Azathioprine in dermatology: the past, the present, and the future. Journal of the American Academy of Dermatology 20060901
Review article: thiopurines in inflammatory bowel disease. Alimentary pharmacology & therapeutics 20060901
[A case report: Severe bone marrow suppression caused by 6-mercaptopurin in Crohn's disease patient]. Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 20060901
Next steps on the thiopurine methyltransferase 6-thioguanine nucleotide pathway. Journal of pediatric gastroenterology and nutrition 20060901
Evolution of thiopurine use in pediatric inflammatory bowel disease in an academic center. Journal of pediatric gastroenterology and nutrition 20060901
[Twenty years of treating childhood acute lymphoblastic leukemia]. Anales de pediatria (Barcelona, Spain : 2003) 20060901
Lack of cross-reactivity between 5-aminosalicylic acid-based drugs: a case report and review of the literature. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20060901
AIDS-associated Burkitt or Burkitt-like lymphoma: short intensive polychemotherapy is feasible and effective. Leukemia & lymphoma 20060901
Treatment of recurrent Langerhans cell histiocytosis in children with 2-chlorodeoxyadenosine. Leukemia & lymphoma 20060901
Asparaginase (native ASNase or pegylated ASNase) in the treatment of acute lymphoblastic leukemia. International journal of nanomedicine 20060901
Cancer treatment-induced mucositis pain: strategies for assessment and management. Therapeutics and clinical risk management 20060901
Nine-year survival of lymphoblastic lymphoma patients. Yonsei medical journal 20060831
Divergent activities of human glutathione transferases in the bioactivation of azathioprine. Molecular pharmacology 20060801
Incidence of neoplasms in patients who develop sustained leukopenia during or after treatment with 6-mercaptopurine for inflammatory bowel disease. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20060801
TPMT, UGT1A1 and DPYD: genotyping to ensure safer cancer therapy? Trends in pharmacological sciences 20060801
Case report: lymphoma arising in an ileal pouch anal anastomosis after immunomodulatory therapy for inflammatory bowel disease. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20060801
Genetic variants and the risk of Crohn's disease: what does it mean for future disease management? Expert opinion on pharmacotherapy 20060801
Physical activity during treatment in children with leukemia: a pilot study. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 20060801
Remission on thiopurinic immunomodulators normalizes quality of life and psychological status in patients with Crohn's disease. Inflammatory bowel diseases 20060801
Severe muscular weakness: an unusual adverse effect of azathioprine therapy. Journal of clinical gastroenterology 20060801
Adverse events leading to modification of therapy in a large cohort of patients with inflammatory bowel disease. Alimentary pharmacology & therapeutics 20060715
Synthesis, hydrolyses and dermal delivery of N-alkyl-N-alkyloxycarbonylaminomethyl (NANAOCAM) derivatives of phenol, imide and thiol containing drugs. Bioorganic & medicinal chemistry letters 20060701
Systematic review of postoperative complications in patients with inflammatory bowel disease treated with immunomodulators. The British journal of surgery 20060701
Postoperative maintenance therapy for inflammatory bowel disease. Current opinion in gastroenterology 20060701
Bis(6-thioxo-1,6-dihydropurinium) tetrachlorozincate(II). Acta crystallographica. Section C, Crystal structure communications 20060701
Pharmacogenetics in inflammatory bowel disease. World journal of gastroenterology 20060621
Inhibition of inducible nitric oxide synthesis by azathioprine in a macrophage cell line. Life sciences 20060620
Erythrocyte concentrations of metabolites or cumulative doses of 6-mercaptopurine and methotrexate do not predict liver changes in children treated for acute lymphoblastic leukemia. Pediatric blood & cancer 20060601
Outcome of treatment in adults with Philadelphia chromosome-positive and/or BCR-ABL--positive acute lymphoblastic leukemia-retrospective analysis of Polish Adult Leukemia Group (PALG). Annals of hematology 20060601
TR3 nuclear orphan receptor prevents cyclic stretch-induced proliferation of venous smooth muscle cells. The American journal of pathology 20060601
Management of refractory ulcerative colitis. Current treatment options in gastroenterology 20060601
Primary endobronchial anaplastic large cell lymphoma in a pediatric patient. Puerto Rico health sciences journal 20060601
Does intravenous 6-mercaptopurine decrease salvage after relapse in childhood acute lymphoblastic leukemia? Pediatric blood & cancer 20060501
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
The significance of minimal residual disease kinetics in adults with newly diagnosed PML-RARalpha-positive acute promyelocytic leukemia: results of a prospective trial. Haematologica 20060501
[HPLC determination and diversity analysis of thiopurine methyltransferase activity in human and pig]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20060501
Involvement of the concentrative nucleoside transporter 3 and equilibrative nucleoside transporter 2 in the resistance of T-lymphoblastic cell lines to thiopurines. Biochemical and biophysical research communications 20060428
Determination of 6-mercaptopurine based on the fluorescence enhancement of Au nanoparticles. Talanta 20060415
Monitoring of inosine monophosphate dehydrogenase activity in mononuclear cells of children with acute lymphoblastic leukemia: enzymological and clinical aspects. Pediatric blood & cancer 20060401
Del(5q) and MLL amplification in homogeneously staining region in acute myeloblastic leukemia: a recurrent cytogenetic association. Annals of hematology 20060401
6-Thioguanine-related hepatotoxicity in patients with inflammatory bowel disease: dose or level dependent? Journal of hepatology 20060401
Risk of lymphoma: inflammatory bowel disease and immunomodulators. Gut 20060401
Role of treatment intensification in infants with acute lymphoblastic leukemia: results of two consecutive AIEOP studies. Haematologica 20060401
Chemoprevention of colorectal neoplasia in ulcerative colitis: the effect of 6-mercaptopurine. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20060401
Association of 6-thioguanine nucleotide levels and inflammatory bowel disease activity: a meta-analysis. Gastroenterology 20060401
Infliximab plus azathioprine for steroid-dependent Crohn's disease patients: a randomized placebo-controlled trial. Gastroenterology 20060401
When is too much enough? Gastroenterology 20060401
Infliximab and azathioprine: bridge or parachute? Gastroenterology 20060401
5-aminosalicylate therapy is associated with higher 6-thioguanine levels in adults and children with inflammatory bowel disease in remission on 6-mercaptopurine or azathioprine. Inflammatory bowel diseases 20060401
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An improved HPLC method for the quantitation of 6-mercaptopurine and its metabolites in red blood cells. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20040501
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Mycophenolate mofetil for the treatment of autoimmune hepatitis in patients refractory to standard therapy. Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20040501
Comprehensive analysis of risk factors associating with Hepatitis B virus (HBV) reactivation in cancer patients undergoing cytotoxic chemotherapy. British journal of cancer 20040405
Methylated metabolites of 6-mercaptopurine are associated with hepatotoxicity. Clinical pharmacology and therapeutics 20040401
Bone marrow necrosis in a patient with acute promyelocytic leukemia during re-induction therapy with arsenic trioxide. European journal of haematology 20040401
The effect on the fetus of medications used to treat pregnant inflammatory bowel-disease patients. The American journal of gastroenterology 20040401
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Analytic aspects of monitoring therapy with thiopurine medications. Therapeutic drug monitoring 20040401
The analysis of correlations between drug resistance and clinical/laboratory measures found in a group of children with all treated by ALL-BFM 90 protocol. Bulletin du cancer 20040401
The risk of congenital abnormalities in children fathered by men treated with azathioprine or mercaptopurine before conception. Alimentary pharmacology & therapeutics 20040315
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A search for the optimal duration of treatment with 6-mercaptopurine for ulcerative colitis. The American journal of gastroenterology 20040301
Toxicity of low dose azathioprine and 6-mercaptopurine in rat hepatocytes. Roles of xanthine oxidase and mitochondrial injury. Journal of hepatology 20040301
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Prolonged remission of severe Crohn's disease after fever and leukopenia caused by 6-mercaptopurine. Digestive diseases and sciences 20040201
Pharmacogenomics and IBD: TPMT and thiopurines. Inflammatory bowel diseases 20040201
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Relevance of thiopurine methyltransferase status in rheumatology patients receiving azathioprine. Rheumatology (Oxford, England) 20040101
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Oral treatment of acute myeloid leukaemia with etoposide, thioguanine, and idarubicin (ETI) in elderly patients: a prospective randomised comparison with intravenous cytarabine, idarubicin, and thioguanine in the second and third treatment cycle. European journal of haematology 20040101
Clinical utility of thiopurine S-methyltransferase genotyping. American journal of pharmacogenomics : genomics-related research in drug development and clinical practice 20040101
Two-day induction with thymoglobulin in kidney transplantation: risks and benefits. Transplantation proceedings 20040101
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Maintenance therapy in childhood acute myeloid leukemia. Annals of hematology 20040101
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[Immunosuppressive therapy of inflammatory diseases of the large intestine]. Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20040101
Optimizing anti-tumor necrosis factor strategies in inflammatory bowel disease. Current gastroenterology reports 20031201
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Role of macrophages and stellate cells in the pathogenesis of veno-occlusive disease: an electron microscopic case study. Experimental and molecular pathology 20031201
Study of ruthenium(II) complexes with anticancer drugs as ligands. Design of metal-based phototherapeutic agents. Inorganic chemistry 20031201
Evidence-based treatment algorithm for mild to moderate Crohn's disease. The American journal of gastroenterology 20031201
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[Relationship between single nucleotide polymorphisms in thiopurine methyltransferase gene and tolerance to thiopurines in acute leukemia]. Zhonghua er ke za zhi = Chinese journal of pediatrics 20031201
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Spectroscopy behavior of 6-Mercaptopurine, Azathiopurine, and 8-Azaguanine. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20031101
Predictive factors of response of perianal Crohn's disease to azathioprine or 6-mercaptopurine. Diseases of the colon and rectum 20031101
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Discussion on the safety of 6-mercaptopurine for childbearing patients with inflammatory bowel disease: a retrospective cohort study. Gastroenterology 20031101
Monitoring of AZA/6-MP treatment in children with IBD is necessary. Inflammatory bowel diseases 20031101
Monitoring of azathioprine/6-mercaptopurine treatment in children with IBD is not necessary. Inflammatory bowel diseases 20031101
6TG: when less is more than you bargained for. Inflammatory bowel diseases 20031101
A novel Escherichia coli strain allows functional analysis of guanylate kinase drug resistance and sensitivity. Analytical biochemistry 20031101
High-performance liquid chromatographic assay of metabolites of thioguanine and mercaptopurine in capillary blood. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20031025
Tertiary structure of thiopurine methyltransferase from Pseudomonas syringae, a bacterial orthologue of a polymorphic, drug-metabolizing enzyme. Journal of molecular biology 20031024
Preventing toxicity with a gene test. Science (New York, N.Y.) 20031024
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Determination of thiopurine methyltransferase phenotype in isolated human erythrocytes using a new simple nonradioactive HPLC method. Therapeutic drug monitoring 20031001
Veno-occlusive disease in patients receiving thiopurines during maintenance therapy for childhood acute lymphoblastic leukaemia. British journal of haematology 20031001
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Cumulative experience with short- and long-term toxicity to 6-mercaptopurine in the treatment of Crohn's disease and ulcerative colitis. Journal of clinical gastroenterology 20030901
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Tioguanine in patients with Crohn's disease intolerant or resistant to azathioprine/mercaptopurine. Alimentary pharmacology & therapeutics 20030815
Analysis of single nucleotide polymorphism C3435T of the multidrug resistance gene MDR1 in acute lymphoblastic leukemia. International journal of oncology 20030801
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Leflunomide treatment of Crohn's disease patients intolerant to standard immunomodulator therapy. Journal of clinical gastroenterology 20030801
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Corticosteroids and immunomodulators: postoperative infectious complication risk in inflammatory bowel disease patients. Gastroenterology 20030801
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Amperometric determination of 6-mercaptopurine on functionalized multi-wall carbon nanotubes modified electrode by liquid chromatography coupled with microdialysis and its application to pharmacokinetics in rabbit. Talanta 20030727
High variation of tioguanine absorption in patients with chronic active Crohn's disease. Alimentary pharmacology & therapeutics 20030715
Study of the interaction of 6-mercaptopurine with protein by microdialysis coupled with LC and electrochemical detection based on functionalized multi-wall carbon nanotubes modified electrode. Journal of pharmaceutical and biomedical analysis 20030714
The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine. The Journal of biological chemistry 20030704
Identification of the antineoplastic agent 6-mercaptopurine as an activator of the orphan nuclear hormone receptor Nurr1. The Journal of biological chemistry 20030704
Real-time RT-PCR methodology for quantification of thiopurine methyltransferase gene expression. European journal of clinical pharmacology 20030701
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Dose reduction of coadministered 6-mercaptopurine decreases myelotoxicity following high-dose methotrexate in childhood leukemia. Leukemia 20030701
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Genetic polymorphism of thiopurine S-methyltransferase in Argentina. Annals of clinical biochemistry 20030701
Erythrocyte mean corpuscular volume as a surrogate marker for 6-thioguanine nucleotide concentration monitoring in patients with inflammatory bowel disease treated with azathioprine or 6-mercaptopurine. Inflammatory bowel diseases 20030701
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Review article: medical treatment of moderate to severe Crohn's disease. Alimentary pharmacology & therapeutics 20030601
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Antagonism by methotrexate on mercaptopurine disposition in lymphoblasts during up-front treatment of acute lymphoblastic leukemia. Clinical pharmacology and therapeutics 20030601
Long-term survival in acute lymphoblastic leukaemia in adults treated according to the LALA 87 protocol. Chemotherapy 20030601
Dexamethasone versus prednisone and daily oral versus weekly intravenous mercaptopurine for patients with standard-risk acute lymphoblastic leukemia: a report from the Children's Cancer Group. Blood 20030515
The role of multidrug resistance protein 1 (MRP1) in transport of fluorescent anions across the human erythrocyte membrane. The Journal of membrane biology 20030515
Treatment-specific changes in gene expression discriminate in vivo drug response in human leukemia cells. Nature genetics 20030501
On-line monitoring of airborne chemistry in levitated nanodroplets: in situ synthesis and application of SERS-active Ag-Sols for trace analysis by FT-Raman spectroscopy. Analytical chemistry 20030501
6-mercaptopurine and inflammatory bowel disease: hidden ground for the cytomegalovirus. Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20030501
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CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes. The Journal of clinical investigation 20030415
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Second malignant neoplasms after treatment of childhood cancer. European journal of cancer (Oxford, England : 1990) 20030401
Intensification of mercaptopurine/methotrexate maintenance chemotherapy may increase the risk of relapse for some children with acute lymphoblastic leukemia. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030401
Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20030401
Topical delivery of 5-fluorouracil and 6-mercaptopurine by their alkylcarbonyloxymethyl prodrugs from water: vehicle effects on design of prodrugs. Pharmaceutical research 20030401
Cancer pharmacogenomics: current and future applications. Biochimica et biophysica acta 20030317
Azathioprine, mercaptopurine and birth outcome: a population-based cohort study. Alimentary pharmacology & therapeutics 20030315
Cytotoxic activity of 6-alkynyl- and 6-alkenylpurines. Bioorganic & medicinal chemistry letters 20030310
Cell proliferation is related to in vitro drug resistance in childhood acute leukaemia. British journal of cancer 20030310
High survival rate in childhood non-Hodgkin lymphoma without CNS involvement: results of BFM 95 study in Kuwait. Pediatric hematology and oncology 20030301
Benign intracranial hypertension in association with acute lymphoblastic leukemia. Pediatric hematology and oncology 20030301
Hepatotoxicity associated with 6-thioguanine therapy for Crohn's disease. Journal of clinical gastroenterology 20030301
Recent advances in immunomodulation in the treatment of inflammatory bowel disease. European journal of gastroenterology & hepatology 20030301
Thiopurine therapy: when to start and when to stop. European journal of gastroenterology & hepatology 20030301
Ciclosporin and refractory colitis. European journal of gastroenterology & hepatology 20030301
Successful reintroduction of methotrexate after acute pneumonitis in a patient with acute lymphoblastic leukemia. Annals of hematology 20030301
Treatment of recurrent eosinophilic granuloma with systemic therapy. Ophthalmic plastic and reconstructive surgery 20030301
First experience with intracytoplasmic sperm injection for extreme oligozoospermia associated with Crohn's disease and 6-mercaptopurine chemotherapy. Asian journal of andrology 20030301
Low dose methotrexate in inflammatory bowel disease: current status and future directions. The American journal of gastroenterology 20030301
Immunomodulators and 'on demand' therapy with infliximab in Crohn's disease: clinical experience with 400 infusions. The American journal of gastroenterology 20030301
[Management of ulcerative colitis]. Therapeutische Umschau. Revue therapeutique 20030301
Comparison of suppressive potency between azathioprine and 6-mercaptopurine against mitogen-induced blastogenesis of human peripheral blood mononuclear cells in-vitro. The Journal of pharmacy and pharmacology 20030301
Position statement: immunomodulator therapy for inflammatory Bowel disease. The Israel Medical Association journal : IMAJ 20030301
[Therapy of chronic inflammatory bowel diseases with azathioprine, 6-mercaptopurine and 6-thioguanine. Clinico-pharmacologic aspects]. Deutsche medizinische Wochenschrift (1946) 20030221
6-thioguanine--efficacy and safety in chronic active Crohn's disease. Alimentary pharmacology & therapeutics 20030215
Effective drug delivery by PEGylated drug conjugates. Advanced drug delivery reviews 20030210
Cyclosporin for refractory ulcerative colitis. Gut 20030201
Diminished anticoagulant effects of warfarin with concomitant mercaptopurine therapy. Pharmacotherapy 20030201
Optimizing treatment with thioguanine derivatives in inflammatory bowel disease. Best practice & research. Clinical gastroenterology 20030201
Safe treatment of thiopurine S-methyltransferase deficient Crohn's disease patients with azathioprine. Gut 20030101
Dental abnormalities in children after chemotherapy treatment for acute lymphoid leukemia. Leukemia research 20030101
Unlicensed and off label drug use in acute lymphoblastic leukaemia and other malignancies in children. Annals of oncology : official journal of the European Society for Medical Oncology 20030101
Review article: immunopathogenetic and therapeutic aspects of autoimmune hepatitis. Alimentary pharmacology & therapeutics 20030101
Mercaptopurine metabolite results in clinical gastroenterology practice. Alimentary pharmacology & therapeutics 20030101
Is thiopurine methyltransferase genetic polymorphism a major factor for withdrawal of azathioprine in rheumatoid arthritis patients? Rheumatology (Oxford, England) 20030101
The safety of 6-mercaptopurine for childbearing patients with inflammatory bowel disease: a retrospective cohort study. Gastroenterology 20030101
Application of pharmacokinetic/pharmacodynamic and stochastic modelling to 6-mercaptopurine micronucleus induction in mouse bone marrow erythrocytes. Journal of applied toxicology : JAT 20030101
[Invasive cancer of the cervix in a patient undergoing chronic treatment with 6-mercaptopurine for Crohns disease]. Gastroenterologia y hepatologia 20030101
Azathioprine and anti-TNF alpha therapies in Crohn's disease: a review of pharmacology, clinical efficacy and safety. Pharmacological research 20030101
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Combination therapy in childhood leukaemia: in vitro studies of thiopurines and inhibitors of purine metabolism on apoptosis. Annals of clinical biochemistry 20030101
Measurement of thiopurine S-methyltransferase activity in human blood samples based on high-performance liquid chromatography: reference values in erythrocytes from children. Annals of clinical biochemistry 20030101
6-Thioguanine seems promising in azathioprine- or 6-mercaptopurine-intolerant inflammatory bowel disease patients: a short-term safety assessment. European journal of gastroenterology & hepatology 20030101
[Inflammatory bowel diseases (IBD) -- critical discussion of etiology, pathogenesis, diagnostics, and therapy]. Der Radiologe 20030101
Investigation of the mechanisms of therapy-related hypoglycaemia in children with acute lymphoblastic leukaemia. Acta paediatrica (Oslo, Norway : 1992) 20030101
Treatment of inflammatory bowel disease in childhood: best available evidence. Inflammatory bowel diseases 20030101
[Significance of TPMT activity and TGNs level detection for individualizing 6-mercaptopurine chemotherapy]. Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20030101
Therapeutic efficacy and safety of 6-mercaptopurine and azathioprine in patients with Crohn's disease. Reviews in gastroenterological disorders 20030101
Clinical use and practical application of TPMT enzyme and 6-mercaptopurine metabolite monitoring in IBD. Reviews in gastroenterological disorders 20030101
Optimizing the therapeutic potential of azathioprine/6-mercaptopurine in the treatment of inflammatory bowel disease. Journal of clinical gastroenterology 20030101
Utility of measuring 6-methylmercaptopurine and 6-thioguanine nucleotide levels in managing inflammatory bowel disease patients treated with 6-mercaptopurine in a clinical practice setting. Journal of clinical gastroenterology 20030101
The yeast ISN1 (YOR155c) gene encodes a new type of IMP-specific 5'-nucleotidase. BMC biochemistry 20030101
Optimization and individualization of thiopurine therapy in inflammatory bowel disease: the great variability among drug responses. The pharmacogenomics journal 20030101
Cytokine and anti-cytokine therapies for inflammatory bowel disease. Current pharmaceutical design 20030101
The state of the art in the management of inflammatory bowel disease. Reviews in gastroenterological disorders 20030101
A national survey on the patterns of treatment of inflammatory bowel disease in Canada. BMC gastroenterology 20030101
[Does conservative therapy of chronic inflammatory bowel diseases still play a role?]. Swiss surgery = Schweizer Chirurgie = Chirurgie suisse = Chirurgia svizzera 20030101
Wegener's granulomatosis: current and upcoming therapies. Arthritis research & therapy 20030101
[The assessment of plasma levels of insulin-like growth factor (IGF-I) and binding protein (IGFBP-3) during the maintenance therapy and after remissionof acute lymphoblastic leukemia (ALL)]. Endokrynologia, diabetologia i choroby przemiany materii wieku rozwojowego : organ Polskiego Towarzystwa Endokrynologow Dzieciecych 20030101
[The influence of age, gender and modifications of therapeutic protocols on physical development of children and adolescents after completion of therapy for acute lymphoblastic leukemia]. Endokrynologia, diabetologia i choroby przemiany materii wieku rozwojowego : organ Polskiego Towarzystwa Endokrynologow Dzieciecych 20030101
A case of leukemia of the appendix presenting as acute appendicitis. Acta haematologica 20030101
Laparoscopic management of complex Crohn's disease. JSLS : Journal of the Society of Laparoendoscopic Surgeons 20030101
Role of red blood cells in pharmacokinetics of chemotherapeutic agents. Clinical pharmacokinetics 20030101
Comparison of the effects of azathioprine and its novel non-mercaptopurine analog on antibody response in rabbits. Polish journal of pharmacology 20030101
Allelic variants of the thiopurine methyltransferase (TPMT) gene in the Colombian population. Methods and findings in experimental and clinical pharmacology 20030101
Pharmacogenomics of azathioprine and 6-mercaptopurine in gastroenterologic therapy. Reviews in gastroenterological disorders 20030101
Low-dose azathioprine is effective and safe for maintenance of remission in patients with ulcerative colitis. Journal of gastroenterology 20030101
Role and side-effects of TPMT polymorphisms of 6-MP and azathioprine in the treatment of steroid-resistant and -dependent ulcerative colitis. Journal of gastroenterology 20030101
[Improved results in children with acute lymphoblastic leukemia treated with the ALL-BFM 90 protocol in the Czech Republic]. Casopis lekaru ceskych 20030101
Thioguanine, mercaptopurine: their analogs and nucleosides as antimetabolites. Current pharmaceutical design 20030101
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Pediatric acute lymphoblastic leukemia. Hematology. American Society of Hematology. Education Program 20030101
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Bioequivalence of azathioprine products. Reviews in gastroenterological disorders 20030101
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Advances in medical therapy for Crohn's disease. Current gastroenterology reports 20021201
Infliximab in the treatment of Crohn's disease: a user's guide for clinicians. The American journal of gastroenterology 20021201
Induction therapy with idarubicin alone significantly influences event-free survival duration in patients with newly diagnosed hypergranular acute promyelocytic leukemia: final results of the GIMEMA randomized study LAP 0389 with 7 years of minimal follow-up. Blood 20021101
Improvement over time in outcome for children with acute lymphoblastic leukemia in second remission given hematopoietic stem cell transplantation from unrelated donors. Leukemia 20021101
Appendectomy protects against the development of ulcerative colitis but does not affect its course. The American journal of gastroenterology 20021101
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Simple chemiluminescence method for the determination of mercaptopurine. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20020901
Spectrophotometric determination of biologically active thiols with eosin, silver(I) and adenine. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20020901
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Biologic and molecular mechanisms for sex differences in pharmacokinetics, pharmacodynamics, and pharmacogenetics: Part I. Journal of women's health & gender-based medicine 20020901
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Use of the photo-micronucleus assay in Chinese hamster V79 cells to study photochemical genotoxicity. Mutation research 20020826
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Protagonist: Crohn's disease recurrence can be prevented after ileal resection. Gut 20020801
Immunosuppressants and operation in ulcerative colitis. Journal of the American College of Surgeons 20020801
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Infliximab improves quality of life in patients with Crohn's disease. Inflammatory bowel diseases 20020701
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[Development of simplified and rapid detection assay for genetic polymorphisms influencing drug response and its clinical applications]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20020701
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Teratogen update: azathioprine and 6-mercaptopurine. Teratology 20020501
Modulation of colony stimulating factor release and apoptosis in human colon cancer cells by anticancer drugs. British journal of cancer 20020422
Novel glutathione-dependent thiopurine prodrugs: evidence for enhanced cytotoxicity in tumor cells and for decreased bone marrow toxicity in mice. The Journal of pharmacology and experimental therapeutics 20020401
6-MP metabolite profiles provide a biochemical explanation for 6-MP resistance in patients with inflammatory bowel disease. Gastroenterology 20020401
Review article: monitoring for drug side-effects in inflammatory bowel disease. Alimentary pharmacology & therapeutics 20020401
Determination of thiopurine S-methyltransferase phenotype using thin-layer chromatography and quantitative scanning. European journal of clinical pharmacology 20020401
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Pharmacological characterization of the ATP-dependent low K(m) guanosine 3',5'-cyclic monophosphate (cGMP) transporter in human erythrocytes. Biochemical pharmacology 20020301
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Successful treatment of postoperative pyoderma gangrenosum with cyclosporin. Journal of the European Academy of Dermatology and Venereology : JEADV 20020301
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Cytotoxic and antibacterial activity of 2-oxopurine derivatives. Bioorganic & medicinal chemistry letters 20020225
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No major cognitive impairment in young children with acute lymphoblastic leukemia using chemotherapy only: a prospective longitudinal study. Journal of pediatric hematology/oncology 20020201
HPLC determination of thiopurine nucleosides and nucleotides in vivo in lymphoblasts following mercaptopurine therapy. Clinical chemistry 20020101
Management of growth retardation in the young patient with Crohn's disease. Expert opinion on pharmacotherapy 20020101
Epstein-Barr virus-positive lymphoma in patients with inflammatory bowel disease treated with azathioprine or 6-mercaptopurine. Gastroenterology 20020101
Recurrent mercaptopurine-induced acute pancreatitis: a rare complication of chemotherapy for acute lymphoblastic leukemia in children. Medical and pediatric oncology 20020101
Prognosis of elderly patients with acute myelogenous leukemia: analysis of 126 AML cases. International journal of hematology 20020101
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Results of a randomized phase III trial in children and adolescents with advanced stage diffuse large cell non-Hodgkin's lymphoma: a Pediatric Oncology Group study. Leukemia & lymphoma 20020101
Pentasomy 8q resulting from duplication of isochromosome 8q in chronic myelomonocytic leukemia. Leukemia & lymphoma 20020101
The thiopurine S-methyltransferase gene locus -- implications for clinical pharmacogenomics. Pharmacogenomics 20020101
Pharmacogenetics: has it reached the clinic? The journal of gender-specific medicine : JGSM : the official journal of the Partnership for Women's Health at Columbia 20020101
Intermediate-dose methotrexate and intravenous 6-mercaptopurine chemotherapy for children with acute lymphoblastic leukemia who did not respond to initial induction therapy. Journal of pediatric hematology/oncology 20020101
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Food-drug interactions. Drugs 20020101
Treatment of inflammatory bowel disease in the elderly: an update. Drugs & aging 20020101
Comparative tolerability of therapies for ulcerative colitis. Drug safety 20020101
Thiopurine methyltransferase polymorphisms in a multiracial asian population and children with acute lymphoblastic leukemia. Journal of pediatric hematology/oncology 20020101
CD7+ and CD56+ myeloid/natural killer cell precursor acute leukemia treated with idarubicin and cytosine arabinoside. Acta haematologica 20020101
Immunosuppressive treatment of Crohn's disease with fistulae. Bratislavske lekarske listy 20020101
Ulcerative colitis in children: medical management. Paediatric drugs 20020101
Preconcentration and separation of copper, zinc and cadmium by the use of 6-mercapto purinylazo resin and their application in microwave digested certified biological samples followed by AAS determination of the metal ions. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 20020101
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The combined effects of antibacterial peptide cecropin A and anti-cancer agents on leukemia cells. Anticancer research 20020101
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Mechanism of azathioprine-induced injury to hepatocytes: roles of glutathione depletion and mitochondrial injury. Journal of hepatology 20011201
Why measure thiopurine methyltransferase activity? Direct administration of 6-thioguanine might be the alternative for 6-mercaptopurine or azathioprine. Gut 20011201
Avoidance of steroids by the early use of infliximab and 6-mercaptopurine in an adolescent with active Crohn's colitis. The American journal of gastroenterology 20011201
Randomized, double-blind, crossover, placebo-controlled trial of intravenous ondansetron for the prevention of intrathecal chemotherapy-induced vomiting in children. Journal of pediatric hematology/oncology 20011201
Successful treatment of refractory Langerhans cell histiocytosis with unrelated cord blood transplantation. Journal of pediatric hematology/oncology 20011201
Unrelated cord blood transplantation for an infant with chemotherapy-resistant progressive Langerhans cell histiocytosis. Journal of pediatric hematology/oncology 20011201
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Diagnosis and treatment of perianal fistulas in Crohn disease. Annals of internal medicine 20011120
In vitro bioassays for anticancer drug screening: effects of cell concentration and other assay parameters on growth inhibitory activity. Cancer letters 20011108
Leucopenia resulting from a drug interaction between azathioprine or 6-mercaptopurine and mesalamine, sulphasalazine, or balsalazide. Gut 20011101
Measurement of thiopurine methyltransferase activity and azathioprine metabolites in patients with inflammatory bowel disease. Gut 20011101
Azathioprine treatment and male fertility in inflammatory bowel disease. Gastroenterology 20011101
Possible implication of thiopurine S-methyltransferase in occurrence of infectious episodes during maintenance therapy for childhood lymphoblastic leukemia with mercaptopurine. Leukemia 20011101
Pitfalls in the determination of mutant alleles of the thiopurine methyltransferase gene. Leukemia 20011101
Review article: the treatment of inflammatory bowel disease with 6-mercaptopurine or azathioprine. Alimentary pharmacology & therapeutics 20011101
Azathioprine for prevention of postoperative recurrence in Crohn's disease. European journal of gastroenterology & hepatology 20011101
Management of fistulas in patients with Crohn's disease: antibiotic to antibody. Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20011101
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Langerhans cell histiocytosis. The Australasian journal of dermatology 20011101
Review article: the limitations of corticosteroid therapy in Crohn's disease. Alimentary pharmacology & therapeutics 20011001
Determination of thiopurine methyltransferase activity in human erythrocytes by high-performance liquid chromatography: comparison with the radiochemical method. Therapeutic drug monitoring 20011001
6-mercaptopurine metabolite levels in children with inflammatory bowel disease. Journal of pediatric gastroenterology and nutrition 20011001
A variant form of acute promyelocytic leukemia with marked myelofibrosis. International journal of hematology 20011001
Managing the glucocorticoid dependent inflammatory bowel disease patient. Seminars in gastrointestinal disease 20011001
Medical management of ulcerative proctitis, proctosigmoiditis, and left-sided colitis. Seminars in gastrointestinal disease 20011001
Modified cyclophosphamide, hydroxydaunorubicin, vincristine, and prednisone therapy for posttransplantation lymphoproliferative disease in pediatric patients undergoing solid organ transplantation. Journal of pediatric hematology/oncology 20011001
Development of obesity and neurochemical backing in aurothioglucose-treated mice. Autonomic neuroscience : basic & clinical 20010917
Transport of cyclic nucleotides and estradiol 17-beta-D-glucuronide by multidrug resistance protein 4. Resistance to 6-mercaptopurine and 6-thioguanine. The Journal of biological chemistry 20010907
Deoxythioguanosine triphosphate impairs HIV replication: a new mechanism for an old drug. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010901
Therapeutic drug monitoring of cytotoxic drugs. British journal of clinical pharmacology 20010901
Neutropenia is not required for clinical remission during azathioprine therapy in inflammatory bowel disease. European journal of gastroenterology & hepatology 20010901
Use of azathioprine or 6-mercaptopurine for treatment of steroid-dependent lymphocytic and collagenous colitis. The American journal of gastroenterology 20010901
Therapy-related CD7+ acute myeloid leukemia with trisomy 8 following acute monocytic leukemia. Anti-cancer drugs 20010901
Single-agent therapy with oral mercaptopurine for nonlymphoid blast crisis of chronic myeloid leukemia. Annals of hematology 20010901
Long-term follow-up of the clinical efficacy of chemotherapy for acute myeloid leukemia at a single institute. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20010901
Review article: the risk of lymphoma associated with inflammatory bowel disease and immunosuppressive treatment. Alimentary pharmacology & therapeutics 20010801
Glucocorticoids and IL-10, but not 6-MP, 5-ASA or sulfasalazine block endothelial expression of MAdCAM-1: implications for inflammatory bowel disease therapy. Alimentary pharmacology & therapeutics 20010801
[Metastatic Crohn's disease in childhood]. Anales espanoles de pediatria 20010801
Differing contribution of thiopurine methyltransferase to mercaptopurine versus thioguanine effects in human leukemic cells. Cancer research 20010801
An open-label pilot study using thioguanine as a therapeutic alternative in Crohn's disease patients resistant to 6-mercaptopurine therapy. Inflammatory bowel diseases 20010801
6-Thioguanine: a naked bullet? (Or how pharmacogenomics can make old drugs brand new). Inflammatory bowel diseases 20010801
Reversal of cytosine arabinoside (ara-C) resistance by the synergistic combination of 6-thioguanine plus ara-C plus PEG-asparaginase (TGAP) in human leukemia lines lacking or expressing p53 protein. Cancer chemotherapy and pharmacology 20010801
Photoactivation of DNA thiobases as a potential novel therapeutic option. Current biology : CB 20010724
Antimycobacterial activity of 9-sulfonylated/sulfenylated-6-mercaptopurine derivatives. Bioorganic & medicinal chemistry letters 20010709
Mechanism of activation of an immunosuppressive drug: azathioprine. Quantum chemical study on the reaction of azathioprine with cysteine. Journal of the American Chemical Society 20010704
A comparison of early intensive methotrexate/mercaptopurine with early intensive alternating combination chemotherapy for high-risk B-precursor acute lymphoblastic leukemia: a Pediatric Oncology Group phase III randomized trial. Leukemia 20010701
Outcome of acute lymphoblastic leukemia in children with AL90 regimen: impact of response to treatment and sex difference on prognostic factors. Medical and pediatric oncology 20010701
If at first you don't succeed...Try again? The American journal of gastroenterology 20010701
Azathioprine for atopic dermatitis. Clinical and experimental dermatology 20010701
Treatment of acute promyelocytic leukaemia using a combination of all-trans retinoic acid and chemotherapy. Annals of the Academy of Medicine, Singapore 20010701
Involvement of the NUP98 gene in a chromosomal translocation t(11;20)(p15;q11.2) in a patient with acute monocytic leukemia (FAB-M5b). International journal of hematology 20010701
Repetitious appearance and disappearance of different kinds of clonal cytogenetic abnormalities after allogeneic bone marrow transplantation. International journal of hematology 20010701
Pneumococcal arthritis affects performance status in patients with chronic GVHD of the skin following allogeneic bone marrow transplantation. International journal of hematology 20010701
Prognostic impact of CD45 antigen expression in high-risk, childhood B-cell precursor acute lymphoblastic leukemia. Leukemia & lymphoma 20010701
Results of a randomized phase III trial in children and adolescents with advanced stage diffuse large cell non Hodgkin's lymphoma: a Pediatric Oncology Group study. Leukemia & lymphoma 20010701
Pediatric inflammatory bowel disease: clinical and therapeutic aspects. Current opinion in gastroenterology 20010701
Improved methods for determining the concentration of 6-thioguanine nucleotides and 6-methylmercaptopurine nucleotides in blood. Journal of chromatography. B, Biomedical sciences and applications 20010605
6-Mercaptopurine for children newly diagnosed with Crohn's disease. Current gastroenterology reports 20010601
Cost-utility of initial medical management for Crohn's disease perianal fistulae. Gastroenterology 20010601
Magnetic resonance imaging detection of avascular necrosis of the bone in children receiving intensive prednisone therapy for acute lymphoblastic leukemia or non-Hodgkin lymphoma. Leukemia 20010601
Rational dosing of azathioprine and 6-mercaptopurine. Gut 20010501
Utilisation of erythrocyte 6-thioguanine metabolite levels to optimise azathioprine therapy in patients with inflammatory bowel disease. Gut 20010501
Treatment of refractory microscopic colitis with azathioprine and 6-mercaptopurine. Gastroenterology 20010501
Conventional treatment of Crohn's disease: objectives and outcomes. Inflammatory bowel diseases 20010501
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Crohn's disease of the esophagus: clinical features and outcomes. Inflammatory bowel diseases 20010501
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Genetic polymorphisms of thiopurine S-methyltransferase and 6-mercaptopurine toxicity in Japanese children with acute lymphoblastic leukaemia. Pharmacogenetics 20010401
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Thiopurine methyltransferase activity in the Jewish population of Israel. European journal of clinical pharmacology 20010401
Genotype-phenotype correlation for thiopurine S-methyltransferase in healthy Italian subjects. European journal of clinical pharmacology 20010401
Effect of the glutathione/glutathione disulfide redox couple on thiopurine methyltransferase. Biochemical pharmacology 20010315
High-throughput genotyping of thiopurine S-methyltransferase by denaturing HPLC. Clinical chemistry 20010301
Fasting hypoglycemia is common during maintenance therapy for childhood acute lymphoblastic leukemia. The Journal of pediatrics 20010301
Plasma pharmacokinetics and cerebrospinal fluid penetration of thioguanine in children with acute lymphoblastic leukemia: a collaborative Pediatric Oncology Branch, NCI, and Children's Cancer Group study. Cancer chemotherapy and pharmacology 20010301
A novel protein complex distinct from mismatch repair binds thioguanylated DNA. Molecular pharmacology 20010201
Testicular relapse in acute promyelocytic leukaemia. British journal of haematology 20010201
Tautomerism and infrared spectra of 2-thiopurine: an experimental matrix isolation and theoretical ab initio and density functional theory study. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20010201
Hepatic dysfunction as the presenting feature of acute lymphoblastic leukemia. Journal of pediatric hematology/oncology 20010201
Smooth muscle tumor developing in an immunocompromised child after therapy for leukemia. Journal of pediatric hematology/oncology 20010201
Tumor lysis syndrome in an infant with Langerhans cell histiocytosis successfully treated using continuous arteriovenous hemofiltration. Journal of pediatric hematology/oncology 20010201
Intravenous cyclosporine in refractory pyoderma gangrenosum complicating inflammatory bowel disease. Inflammatory bowel diseases 20010201
New developments in the immunosuppressive drug monitoring of cyclosporine, tacrolimus, and azathioprine. Clinical biochemistry 20010201
Induction therapy of adult acute lymphocytic leukemia without the use of vincristine or prednisone. Hematology/oncology clinics of North America 20010201
A multicenter trial of 6-mercaptopurine and prednisone in children with newly diagnosed Crohn disease. Journal of pediatric gastroenterology and nutrition 20010201
Langerhans' cell histiocytosis presenting with a para-aortic lesion and heart failure. Journal of the Formosan Medical Association = Taiwan yi zhi 20010201
New bioactive sulfated metabolites from the Mediterranean tunicate Sidnyum turbinatum. Journal of natural products 20010201
The use of denaturing high-pressure liquid chromatography for the detection of mutations in thiopurine methyltransferase. Journal of biochemical and biophysical methods 20010130
Long-term results of TPMT activity monitoring in azathioprine-treated renal allograft recipients. Journal of the American Society of Nephrology : JASN 20010101
Stochastic modeling in toxicokinetics. Application to the in vivo micronucleus assay. Mathematical biosciences 20010101
De novo acute myeloid leukemia in the elderly; a consistent fraction of long-term survivors by standard-dose chemotherapy. Leukemia research 20010101
Molecular dynamics of DNA quadruplex molecules containing inosine, 6-thioguanine and 6-thiopurine. Biophysical journal 20010101
Frequency of use and standards of care for the use of azathioprine and 6-mercaptopurine in the treatment of inflammatory bowel disease: a systematic review of the literature and a survey of Canadian gastroenterologists. Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20010101
WAGR syndrome in a baby--the result of 6-MP treatment in a father affected by Crohn's disease? The American journal of gastroenterology 20010101
Further evidence that 6-MP taken by the father with IBD provides risk of congenital anomaly to the pregnancy. The American journal of gastroenterology 20010101
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Therapeutic drug monitoring of azathioprine and 6-mercaptopurine metabolites in Crohn disease. Scandinavian journal of gastroenterology 20010101
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Prognostic value of day 14 blast percentage and the absolute blast index in bone marrow of children with acute lymphoblastic leukemia. Pediatric hematology and oncology 20010101
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