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50-03-3 | Hydrocortisone acetate
CAS No: 50-03-3 Catalog No: AG003QYO MDL No:MFCD00037714
Product Description
Catalog Number:
AG003QYO
Chemical Name:
Hydrocortisone acetate
CAS Number:
50-03-3
Molecular Formula:
C23H32O6
Molecular Weight:
404.4966
MDL Number:
MFCD00037714
IUPAC Name:
[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
InChI:
InChI=1S/C23H32O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-18,20,26,28H,4-9,11-12H2,1-3H3/t16-,17-,18-,20+,21-,22-,23-/m0/s1
InChI Key:
ALEXXDVDDISNDU-JZYPGELDSA-N
SMILES:
CC(=O)OCC(=O)[C@@]1(O)CC[C@@H]2[C@]1(C)C[C@H](O)[C@H]1[C@H]2CCC2=CC(=O)CC[C@]12C
EC Number:
200-004-4
UNII:
3X7931PO74
NSC Number:
741
Properties
Complexity:
786
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
7
Defined Bond Stereocenter Count:
0
Exact Mass:
404.22g/mol
Formal Charge:
0
Heavy Atom Count:
29
Hydrogen Bond Acceptor Count:
6
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
404.503g/mol
Monoisotopic Mass:
404.22g/mol
Rotatable Bond Count:
4
Topological Polar Surface Area:
101A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.2
Literature
| Title | Journal |
|---|---|
| A β-cyclodextrin, polyethyleneimine and silk fibroin hydrogel containing Centella asiatica extract and hydrocortisone acetate: releasing properties and in vivo efficacy for healing of pressure sores. | Clinical and experimental dermatology 20121001 |
| Papulopustular eruptions in a 32-year-old woman after lung cancer treatment. | Archives of dermatology 20110601 |
| Papular colpitis: a distinct clinical entity? Symptoms, signs, histopathological diagnosis, and treatment in a series of patients seen at the Rotterdam vulvar clinic. | Journal of lower genital tract disease 20110101 |
| Dual excitation wavelength epifluorescence imaging of transmural electrophysiological properties in intact hearts. | Heart rhythm 20101201 |
| An open-label trial examining the efficacy and safety of a pre- and postprocedure topical five-product system (Clinique Medical Optimizing Regimen) specifically formulated to complement laser/light-based facial cosmetic procedures. | Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology 20101201 |
| Effectiveness of budesonide-succinate-dextran conjugate as a novel prodrug of budesonide against acetic acid-induced colitis in rats. | International journal of colorectal disease 20101001 |
| Image intensifier-guided injection of corticosteroid and local anesthetic agent for the treatment of recalcitrant plantar fasciitis. | Foot & ankle specialist 20100801 |
| Corticosteroid solubility and lipid polarity control release from solid lipid nanoparticles. | International journal of pharmaceutics 20100505 |
| Efficacy of hydrocortisone acetate/hyaluronidase vs triamcinolone acetonide/hyaluronidase in the treatment of oral submucous fibrosis. | The Indian journal of medical research 20100501 |
| One-year treatment with 0.1% tacrolimus ointment versus a corticosteroid regimen in adults with moderate to severe atopic dermatitis: A randomized, double-blind, comparative trial. | Acta dermato-venereologica 20100301 |
| Suppression of corticosteroid-induced ocular hypertension in sheep by anecortave. | Archives of ophthalmology (Chicago, Ill. : 1960) 20100301 |
| Novel nanoparticulate gel formulations of steroids for the treatment of macular edema. | Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20100201 |
| Optimization and validation of an RP-HPLC method for analysis of hydrocortisone acetate and lidocaine in suppositories. | Journal of AOAC International 20100101 |
| Meningeal dissemination from an ovarian carcinoma with effective response to intrathecal chemotherapy. | International journal of clinical oncology 20091001 |
| Effects of elevated circulating cortisol concentrations on maternal behavior in common marmoset monkeys (Callithrix jacchus). | Psychoneuroendocrinology 20090901 |
| Ligneous cervicitis: an unusual cause of post-coital bleeding in a postmenopausal woman. | Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 20090201 |
| Unilateral pruritic axillary rash: axillary granular parakeratosis. | Archives of dermatology 20081201 |
| Antimicrobial activity of iodoquinol 1%-hydrocortisone acetate 2% gel against ciclopirox and clotrimazole. | Cutis 20081001 |
| Control of transdermal permeation of hydrocortisone acetate from hydrophilic and lipophilic formulations. | AAPS PharmSciTech 20080901 |
| Neuroendocrine disorders in adult rats treated prenatally with hydrocortisone acetate. | Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20080901 |
| UVB photolysis of hydrocortisone 21-acetate. | Journal of pharmaceutical and biomedical analysis 20080805 |
| Response to lactation induction differs by season of year and breed of dairy ewes. | Journal of dairy science 20080601 |
| High volume image guided injections in chronic Achilles tendinopathy. | Disability and rehabilitation 20080101 |
| Separation of corticosteroids by microemulsion EKC with diethyl L-tartrate as the oil phase. | Electrophoresis 20071001 |
| Topical treatment of acute otitis externa: clinical comparison of an antibiotics ointment alone or in combination with hydrocortisone acetate. | European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20070901 |
| [Using ultra performance liquid chromatography]. | Se pu = Chinese journal of chromatography 20070701 |
| Polymethylmethacrylate contact dermatitis after vertebroplasty. | Journal of vascular and interventional radiology : JVIR 20070401 |
| Assessment of topical corticosteroid activity using the vasoconstriction assay in healthy volunteers. | Skin pharmacology and physiology 20070101 |
| Pimecrolimus cream, 1%, vs hydrocortisone acetate cream, 1%, in the treatment of facial seborrheic dermatitis: a randomized, investigator-blind, clinical trial. | Archives of dermatology 20060801 |
| Contact allergy to para-phenylenediamine in a permanent eyelash dye. | Contact dermatitis 20060801 |
| Aqueous chromatography system using pH- and temperature-responsive stationary phase with ion-exchange groups. | Journal of chromatography. A 20060630 |
| Study of temperature-responsibility on the surfaces of a thermo-responsive polymer modified stationary phase. | Journal of chromatography. A 20060630 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| Lower birth weight and attenuated adrenocortical response to ACTH in offspring from sows that orally received cortisol during gestation. | Domestic animal endocrinology 20060301 |
| [Sex characteristics of neuroendocrine effects of prenatal exposure to exogenous glucocorticoids]. | Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20060201 |
| New method for the effective production of ultrafine drug nanocrystals. | Journal of nanoscience and nanotechnology 20060101 |
| [Esterase activity of human organotypic cornea construct (HCC) as in vitro model for permeation studies]. | Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 20051001 |
| [Application of preparations relief ultra and relief advance in practice of coloproctological department]. | Klinichna khirurhiia 20051001 |
| A multicentre, randomized, double-blind, controlled study of long-term treatment with 0.1% tacrolimus ointment in adults with moderate to severe atopic dermatitis. | The British journal of dermatology 20050601 |
| External otitis caused by infection with Pseudomonas aeruginosa or Candida albicans cured by use of a topical group III steroid, without any antibiotics. | Acta oto-laryngologica 20050401 |
| Central serous chorioretinopathy after local application of glucocorticoids for skin disorders. | Archives of ophthalmology (Chicago, Ill. : 1960) 20040501 |
| 0.03% Tacrolimus ointment applied once or twice daily is more efficacious than 1% hydrocortisone acetate in children with moderate to severe atopic dermatitis: results of a randomized double-blind controlled trial. | The British journal of dermatology 20040301 |
| [Cervugid ovules in cervico-vaginal infections and cervix uteri precancerous conditions treatment]. | Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20040101 |
| Simultaneous determination of methylparaben, propylparaben, hydrocortisone acetate and its degradation products in a topical cream by RP-HPLC. | Journal of pharmaceutical and biomedical analysis 20030808 |
| Effects of prenatal hydrocortisone acetate exposure on fertility and sexual behavior in male rats. | Regulatory toxicology and pharmacology : RTP 20030801 |
| Budesonide foam vs. hydrocortisone acetate foam in the treatment of active ulcerative proctosigmoiditis. | Diseases of the colon and rectum 20030701 |
| L-arginine transport in humans with cortisol-induced hypertension. | Hypertension (Dallas, Tex. : 1979) 20030601 |
| [Effect of hydrocortisone on peripheral blood phagocytic cells under beta-adrenoreceptors blockade]. | Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20030501 |
| Treatment of vaginal outflow tract obstruction in graft-versus-host reaction. | American journal of obstetrics and gynecology 20030401 |
| 11 beta-Hydroxysteroid dehydrogenase activity in hypothalamic obesity. | The Journal of clinical endocrinology and metabolism 20030101 |
| Topical nifedipine with lidocaine ointment vs. active control for treatment of chronic anal fissure: results of a prospective, randomized, double-blind study. | Diseases of the colon and rectum 20021101 |
| Comparison of HPLC and multivariate regression methods for hydrocortisone and lidocaine analysis of pharmaceutical preparations. | Analytical and bioanalytical chemistry 20020901 |
| Viscoelastic evaluation of topical creams containing microcrystalline cellulose/sodium carboxymethyl cellulose as stabilizer. | AAPS PharmSciTech 20020601 |
| [Corticosteroid-free therapy for the neurodermatitis patient. Rapid cessation for tormenting urticaria]. | MMW Fortschritte der Medizin 20020516 |
| Efficacy and safety of tacrolimus ointment compared with that of hydrocortisone acetate ointment in children with atopic dermatitis. | The Journal of allergy and clinical immunology 20020301 |
| Pseudo-septic meningeal reaction after intradural glucocorticoid therapy for sciatica. | Joint, bone, spine : revue du rhumatisme 20020101 |
| The painful shoulder. | The Practitioner 20011201 |
| ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. | Journal of medicinal chemistry 20010719 |
| Membrane transport of hydrocortisone acetate from supersaturated solutions; the role of polymers. | International journal of pharmaceutics 20010619 |
| Pharmacokinetics and rectal bioavailability of hydrocortisone acetate after single and multiple administration in healthy subjects and patients. | Journal of clinical pharmacology 20010501 |
| Crystallization of hydrocortisone acetate: influence of polymers. | International journal of pharmaceutics 20010116 |
| Design and evaluation of buccal adhesive hydrocortisone acetate (HCA) tablets. | Drug delivery 20010101 |
| Complications of lumbar puncture with injection of hydrosoluble material. | Journal of spinal disorders 19990401 |
| Spin-spin relaxation times in myocardial hypertrophy induced by endocrine agents in rat. | Magma (New York, N.Y.) 19981201 |
| Glucocorticoid teratogenesis in the developing nephron. | Teratology 19910601 |
| Hydrocortisone rapidly induces aortic rupture in a genetically susceptible mouse. | Archives of surgery (Chicago, Ill. : 1960) 19900601 |
| Glucocorticoid-induced polycystic kidney disease--a threshold trait. | Kidney international 19900301 |
| Initiating regular exercise protects against muscle atrophy from glucocorticoids. | Journal of applied physiology (Bethesda, Md. : 1985) 19871001 |
| The treatment of steroid-induced rosacea and perioral dermatitis. | Dermatologica 19760101 |
| Extraordinary potentiation of isoproterenol cardiotoxicity by corticoid pretreatment. | Cardiovascular research 19741101 |
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