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486-12-4 | Pyridine, 2-[(1E)-1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]-
CAS No: 486-12-4 Catalog No: AG01DQ86 MDL No:MFCD00038040
Product Description
Catalog Number:
AG01DQ86
Chemical Name:
Pyridine, 2-[(1E)-1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]-
CAS Number:
486-12-4
MDL Number:
MFCD00038040
IUPAC Name:
2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine
InChI:
InChI=1S/C19H22N2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H3/b18-11+
InChI Key:
CBEQULMOCCWAQT-WOJGMQOQSA-N
EC Number:
207-627-0
UNII:
2L8T9S52QM
Properties
Complexity:
336
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
1
Exact Mass:
278.178g/mol
Formal Charge:
0
Heavy Atom Count:
21
Hydrogen Bond Acceptor Count:
2
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
278.399g/mol
Monoisotopic Mass:
278.178g/mol
Rotatable Bond Count:
4
Topological Polar Surface Area:
16.1A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.9
Literature
| Title | Journal |
|---|---|
| Why are most phospholipidosis inducers also hERG blockers? | Archives of toxicology 20171201 |
| Development and validation of a liquid chromatography-tandem mass spectrometry method for the simultaneous determination of acrivastine and pseudoephedrine in human plasma and its application in pharmacokinetics. | Arzneimittel-Forschung 20121001 |
| H1-antihistamines induce vacuolation in astrocytes through macroautophagy. | Toxicology and applied pharmacology 20120415 |
| Applicability of total reflection X-ray fluorescence (TXRF) as a screening platform for pharmaceutical inorganic impurity analysis. | Journal of pharmaceutical and biomedical analysis 20120407 |
| Synthesis of aryl(di)azinyl ketones through copper- and iron-catalyzed oxidation of the methylene group of aryl(di)azinylmethanes. | Angewandte Chemie (International ed. in English) 20120312 |
| Solubility-modulated asymmetric membrane tablets of triprolidine hydrochloride: statistical optimization and evaluation. | AAPS PharmSciTech 20120301 |
| Persistent histamine excitation of glutamatergic preoptic neurons. | PloS one 20120101 |
| ['Of snakes and crocodiles': central side effects of nose drops and facts about rhinitis medicamentosa]. | Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege 20111001 |
| Involvement of histaminergic receptor mechanisms in the stimulation of NT-3 synthesis in astrocytes. | Neuropharmacology 20110601 |
| Interaction of triprolidine hydrochloride with serum albumins: thermodynamic and binding characteristics, and influence of site probes. | Journal of pharmaceutical and biomedical analysis 20110405 |
| Dopamine transporter-dependent and -independent striatal binding of the benztropine analog JHW 007, a cocaine antagonist with low abuse liability. | The Journal of pharmacology and experimental therapeutics 20101201 |
| Endogenous histamine facilitates long-term potentiation in the hippocampus during walking. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20100609 |
| Involvement of histamine 1 receptor in seizure susceptibility and neuroprotection in immature mice. | Epilepsy research 20100601 |
| Simultaneous HPLC analysis of pseudophedrine hydrochloride, codeine phosphate, and triprolidine hydrochloride in liquid dosage forms. | Journal of pharmaceutical and biomedical analysis 20100311 |
| Simultaneous determination of triprolidine and pseudoephedrine in human plasma by liquid chromatography-ion trap mass spectrometry. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20091215 |
| General anesthesia and ascending arousal pathways. | Anesthesiology 20091001 |
| Involvement of the organic cation transporters in histamine uptake into human vascular endothelial cells. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20090401 |
| Bivariate or composite plots of endpoints. | Journal of biopharmaceutical statistics 20090101 |
| Cocaine-like neurochemical effects of antihistaminic medications. | Journal of neurochemistry 20080701 |
| Disruption of the C5a receptor gene increases resistance to acute Gram-negative bacteremia and endotoxic shock: opposing roles of C3a and C5a. | Molecular immunology 20080401 |
| Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model. | Journal of medicinal chemistry 20080124 |
| Quantification of antihistamine acrivastine in plasma by solid-phase extraction and high-performance liquid chromatography. | Journal of pharmaceutical and biomedical analysis 20070104 |
| H1 histamine receptor antagonists induce genotoxic and caspase-2-dependent apoptosis in human melanoma cells. | Carcinogenesis 20060901 |
| Histamine improves rat rota-rod and balance beam performances through H(2) receptors in the cerebellar interpositus nucleus. | Neuroscience 20060619 |
| Histamine excites neonatal rat sympathetic preganglionic neurons in vitro via activation of H1 receptors. | Journal of neurophysiology 20060401 |
| Histaminergic neurons protect the developing hippocampus from kainic acid-induced neuronal damage in an organotypic coculture system. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20060125 |
| Spectrophotometric determination of some antihistaminic drugs using 7,7,8,8-tetracyanoquinodimethane (TCNQ). | Journal of AOAC International 20060101 |
| The butterbur extract petasin has no effect on skin test reactivity induced by different stimuli: a randomized, double-blind crossover study using histamine, codeine, methacholine, and aeroallergen solutions. | Journal of investigational allergology & clinical immunology 20060101 |
| Excitatory effect of histamine on neuronal activity of rat globus pallidus by activation of H2 receptors in vitro. | Neuroscience research 20051101 |
| Transport of hydroxyzine and triprolidine across bovine olfactory mucosa: role of passive diffusion in the direct nose-to-brain uptake of small molecules. | International journal of pharmaceutics 20050930 |
| Enhanced efficacy of triprolidine by transdermal application of the EVA matrix system in rabbits and rats. | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20050901 |
| Prediction of genotoxicity of chemical compounds by statistical learning methods. | Chemical research in toxicology 20050601 |
| Simultaneous analysis of the H1-antihistamine acrivastine and the decongestant pseudoephedrine hydrochloride by high-performance liquid chromatography. | Journal of pharmaceutical and biomedical analysis 20050401 |
| Antihistamine effects of triprolidine from the transdermal administration of the TPX matrix in rats. | Archives of pharmacal research 20050101 |
| Adsorptive stripping voltammetric determination of triprolidine hydrochloride in pharmaceutical tablets. | Farmaco (Societa chimica italiana : 1989) 20050101 |
| Homology modelling and binding site mapping of the human histamine H1 receptor. | European journal of medicinal chemistry 20041101 |
| Mepyramine, a histamine H1 receptor inverse agonist, binds preferentially to a G protein-coupled form of the receptor and sequesters G protein. | The Journal of biological chemistry 20040813 |
| New plastic membrane and carbon paste ion selective electrodes for the determination of triprolidine. | Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20040701 |
| Regulation of cytokine production in carcinoembryonic antigen stimulated Kupffer cells by beta-2 adrenergic receptors: implications for hepatic metastasis. | Cancer letters 20040625 |
| Activation of histamine H1-receptor enhances neurotrophic factor secretion from cultured astrocytes. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20040601 |
| Evaluation and comparison of five matrix excipients for the controlled release of acrivastine and pseudoephedrine. | Drug development and industrial pharmacy 20040101 |
| Histamine inhibits atrial myocytic ANP release via H2 receptor-cAMP-protein kinase signaling. | American journal of physiology. Regulatory, integrative and comparative physiology 20030801 |
| gp49B1 suppresses stem cell factor-induced mast cell activation-secretion and attendant inflammation in vivo. | European journal of immunology 20030801 |
| The early allergic response in small airways of human precision-cut lung slices. | The European respiratory journal 20030601 |
| Treatment of the common cold. | Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20030601 |
| Molecular characterization of specific H1-receptor agonists histaprodifen and its Nalpha-substituted analogues on bovine aortic H1-receptors. | Naunyn-Schmiedeberg's archives of pharmacology 20030501 |
| Zafirlukast has no beneficial effects in the treatment of chronic urticaria. | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20021201 |
| Electrochemical behaviour and determination of acrivastine in pharmaceuticals and human urine. | Journal of pharmaceutical and biomedical analysis 20021107 |
| Enhanced transdermal delivery of triprolidine from the ethylene-vinyl acetate matrix. | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20021101 |
| Excitatory effects of histamine on cerebellar interpositus nuclear cells of rats through H(2) receptors in vitro. | Brain research 20020906 |
| Controlled release of triprolidine using ethylene-vinyl acetate membrane and matrix systems. | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20020901 |
| A novel phenylaminotetralin radioligand reveals a subpopulation of histamine H(1) receptors. | The Journal of pharmacology and experimental therapeutics 20020701 |
| Endogenous histamine in the medial septum-diagonal band complex increases the release of acetylcholine from the hippocampus: a dual-probe microdialysis study in the freely moving rat. | The European journal of neuroscience 20020501 |
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
| Transdermal delivery of triprolidine using TPX polymer membrane. | International journal of pharmaceutics 20020320 |
| Enhanced bioavailability of triprolidine from the transdermal TPX matrix system in rabbits. | International journal of pharmaceutics 20020302 |
| Cardiotoxicity of new antihistamines and cisapride. | Toxicology letters 20020227 |
| Application of TPX polymer membranes for the controlled release of triprolidine. | International journal of pharmaceutics 20020131 |
| Kinetic spectrophotometric methods for the quantitation of triprolidine in bulk and in drug formulations. | Journal of pharmaceutical and biomedical analysis 20010901 |
| Regional differences in functional receptor distribution and calcium mobilization in the intact human lens. | Investigative ophthalmology & visual science 20010901 |
| Increased histidine decarboxylase expression during in vitro monocyte maturation; a possible role of endogenously synthesised histamine in monocyte/macrophage differentiation. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20010801 |
| Lipophilicity behaviour of the Zwitterionic antihistamine cetirizine in phosphatidylcholine liposomes/water systems. | Pharmaceutical research 20010501 |
| Inhibition of effects of endogenously synthesized histamine disturbs in vitro human dendritic cell differentiation. | Immunology letters 20010402 |
| Role of mast cells in zymosan-induced peritoneal inflammation in Balb/c and mast cell-deficient WBB6F1 mice. | Journal of leukocyte biology 20010101 |
| The effects of single and repeated administration of ebastine on cognition and psychomotor performance in comparison to triprolidine and placebo in healthy volunteers. | Current medical research and opinion 20010101 |
| Sedation with 'non-sedating' antihistamines: four prescription-event monitoring studies in general practice. | BMJ (Clinical research ed.) 20000429 |
| A novel phenylaminotetralin (PAT) recognizes histamine H1 receptors and stimulates dopamine synthesis in vivo in rat brain. | Brain research 20000103 |
| Risk of ventricular arrhythmias associated with nonsedating antihistamine drugs. | British journal of clinical pharmacology 19990301 |
| Histamine inhibits the production of interleukin-12 through interaction with H2 receptors. | The Journal of clinical investigation 19981115 |
| The histamine H1-receptor antagonist binding site. A stereoselective pharmacophoric model based upon (semi-)rigid H1-antagonists and including a known interaction site on the receptor. | Journal of medicinal chemistry 19950818 |
| Stable expression of human H1-histamine-receptor cDNA in Chinese hamster ovary cells. Pharmacological characterisation of the protein, tissue distribution of messenger RNA and chromosomal localisation of the gene. | European journal of biochemistry 19940901 |
| A role for endogenous histamine in interleukin-8-induced neutrophil infiltration into mouse air-pouch: investigation of the modulatory action of systemic and local dexamethasone. | British journal of pharmacology 19940701 |
| H1-receptor antagonists. Comparative tolerability and safety. | Drug safety 19940501 |
| The role of receptor binding in drug discovery. | Journal of natural products 19930401 |
| Decreased histamine H1 receptors in the frontal cortex of brains from patients with chronic schizophrenia. | Biological psychiatry 19910815 |
| Nonsedating histamine H1-receptor antagonists. | Clinical pharmacy 19890501 |
| A comparison of acrivastine versus terfenadine and placebo in the treatment of chronic idiopathic urticaria. | The Journal of international medical research 19890101 |
| A comparison of acrivastine versus hydroxyzine and placebo in the treatment of chronic idiopathic urticaria. | The Journal of international medical research 19890101 |
| A comparison of acrivastine versus clemastine and placebo in the treatment of patients with chronic idiopathic urticaria. | The Journal of international medical research 19890101 |
| A comparison of acrivastine versus chlorpheniramine in the treatment of chronic idiopathic urticaria. | The Journal of international medical research 19890101 |
| Effects of triprolidine and dipipanone in the cold induced pain test, and the central nervous system of healthy volunteers. | British journal of clinical pharmacology 19870701 |
| Pharmacologic analysis of LY188695 (KB-2413), 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)-benzimidazole difumarate, a potent histamine1 receptor antagonist. | Agents and actions 19870201 |
| Regulation of membrane histamine H1-receptor binding sites by guanine nucleotides, mono- and divalent cations. | Agents and actions 19860401 |
| H1-histamine receptors on human astrocytoma cells. | Molecular pharmacology 19860201 |
| Clinical pharmacokinetics of H1-receptor antagonists (the antihistamines). | Clinical pharmacokinetics 19850101 |
| Visual hallucinations in children receiving decongestants. | British medical journal (Clinical research ed.) 19840602 |
| Visual hallucinations in children receiving decongestants. | British medical journal (Clinical research ed.) 19840505 |
| An assessment of the novel antihistamine BW 825C in the treatment of chronic idiopathic urticaria. A placebo-controlled study. | Dermatologica 19840101 |
| Specific binding of [3H]mepyramine to histamine H1-receptors in vascular smooth muscle membranes. | Agents and actions 19830401 |
| [Myoclonia caused by a combination of triprolidine, pseudoephedrine and paracetamol]. | La Nouvelle presse medicale 19820626 |
| Clinical and therapeutic aspects of sinusitis in children with bronchial asthma. | International journal of pediatric otorhinolaryngology 19811201 |
| Apnoea in a 3-month-old baby prescribed compound linctus containing codeine. | Lancet (London, England) 19810523 |
| Angina associated with pseudoephedrine. | Annals of emergency medicine 19810401 |
| A Double-blind crossover trial of pseudoephedrine and triprolidine, alone and in combination, for the treatment of allergenic rhinitis. | Annals of allergy 19750101 |
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