200,000+ products from a single source!
sales@angenechem.com
478-57-9 | 4H-Dibenzo[de,g]quinoline,5,6,6a,7-tetrahydro-6-methyl-
CAS No: 478-57-9 Catalog No: AG006YOA MDL No:
Product Description
Catalog Number:
AG006YOA
Chemical Name:
4H-Dibenzo[de,g]quinoline,5,6,6a,7-tetrahydro-6-methyl-
CAS Number:
478-57-9
Molecular Formula:
C17H17N
Molecular Weight:
235.3236
IUPAC Name:
6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline
InChI:
InChI=1S/C17H17N/c1-18-10-9-12-6-4-8-15-14-7-3-2-5-13(14)11-16(18)17(12)15/h2-8,16H,9-11H2,1H3
InChI Key:
BZKUYNBAFQJRDM-UHFFFAOYSA-N
SMILES:
CN1CCc2c3C1Cc1ccccc1c3ccc2
Properties
Complexity:
313
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
235.136g/mol
Formal Charge:
0
Heavy Atom Count:
18
Hydrogen Bond Acceptor Count:
1
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
235.33g/mol
Monoisotopic Mass:
235.136g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
3.2A^2
Undefined Atom Stereocenter Count:
1
Undefined Bond Stereocenter Count:
0
XLogP3:
3
Literature
| Title | Journal |
|---|---|
| Acetylcholinesterase inhibition, antioxidant activity and toxicity of Peumus boldus water extracts on HeLa and Caco-2 cell lines. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120801 |
| The pharmacological properties and therapeutic use of apomorphine. | Molecules (Basel, Switzerland) 20120507 |
| New cholinesterase inhibiting bisbenzylisoquinoline alkaloids from Abuta grandifolia. | Fitoterapia 20120401 |
| Application of design of experiments and design space methodology for the HPLC-UV separation optimization of aporphine alkaloids from leaves of Spirospermum penduliflorum Thouars. | Journal of pharmaceutical and biomedical analysis 20120325 |
| Anti-acetylcholinesterase, anti-α-glucosidase, anti-leishmanial and anti-fungal activities of chemical constituents of Beilschmiedia species. | Fitoterapia 20120301 |
| Novel marine phenazines as potential cancer chemopreventive and anti-inflammatory agents. | Marine drugs 20120201 |
| An aporphine alkaloid from Nelumbo nucifera as an acetylcholinesterase inhibitor and the primary investigation for structure-activity correlations. | Natural product research 20120101 |
| Aporphine alkaloids and feruloylamides from the bark of Xylopia benthamii R.E. Fries (Annonaceae). | Natural product research 20120101 |
| Cytotoxic and antimicrobial aporphine alkaloids from Fissistigma poilanei (Annonaceae) collected in Vietnam. | Natural product research 20120101 |
| The aporphine alkaloid boldine improves endothelial function in spontaneously hypertensive rats. | Experimental biology and medicine (Maywood, N.J.) 20120101 |
| Annonamine, a new aporphine alkaloid from the leaves of Annona muricata. | Chemical & pharmaceutical bulletin 20120101 |
| Secondary Metabolites from Plants Inhibiting ABC Transporters and Reversing Resistance of Cancer Cells and Microbes to Cytotoxic and Antimicrobial Agents. | Frontiers in microbiology 20120101 |
| Insufficient radiofrequency ablation promotes angiogenesis of residual hepatocellular carcinoma via HIF-1α/VEGFA. | PloS one 20120101 |
| Isocorydine inhibits cell proliferation in hepatocellular carcinoma cell lines by inducing G2/m cell cycle arrest and apoptosis. | PloS one 20120101 |
| Antinociceptive activity of ethanol extract from Duguetia chrysocarpa Maas (Annonaceae). | TheScientificWorldJournal 20120101 |
| Chemical constituents with free-radical-scavenging activities from the stem of Fissistigma polyanthum. | Pharmacognosy magazine 20120101 |
| 2D MI-DRAGON: a new predictor for protein-ligands interactions and theoretic-experimental studies of US FDA drug-target network, oxoisoaporphine inhibitors for MAO-A and human parasite proteins. | European journal of medicinal chemistry 20111201 |
| Polar compounds isolated from the leaves of Albertisia delagoensis (Menispermaceae). | Molecules (Basel, Switzerland) 20111102 |
| Selective separation of structure-related alkaloids in Rhizoma coptidis with 'click' binaphthyl stationary phase and their structural elucidation with liquid chromatography-mass spectrometry. | The Analyst 20111021 |
| Cytotoxic and antimicrobial activities of aporphine alkaloids isolated from Stephania venosa (Blume) Spreng. | Planta medica 20110901 |
| Chemical constituents of Talauma arcabucoana (Magnoliaceae): their brine shrimp lethality and antimicrobial activity. | Natural product research 20110901 |
| Cytotoxicity of aporphines in human colon cancer cell lines HCT-116 and Caco-2: an SAR study. | Bioorganic & medicinal chemistry letters 20110801 |
| Identification of N-propylnoraporphin-11-yl 5-(1,2-dithiolan-3-yl)pentanoate as a new anti-Parkinson's agent possessing a dopamine D2 and serotonin 5-HT1A dual-agonist profile. | Journal of medicinal chemistry 20110714 |
| New 2-thioether-substituted apomorphines as potent and selective dopamine D₂ receptor agonists. | European journal of medicinal chemistry 20110701 |
| A novel aporphine alkaloid from Magnolia officinalis. | Fitoterapia 20110601 |
| N-cyanomethylnorboldine: a new aporphine isolated from Alseodaphne perakensis (Lauraceae). | Molecules (Basel, Switzerland) 20110420 |
| Alkaloidal variation in cissampelos capensis (Menispermaceae). | Molecules (Basel, Switzerland) 20110407 |
| A new dimeric aporphine from the roots of Artabotrys spinosus. | Fitoterapia 20110401 |
| Aporphine alkaloids and cytotoxic lignans from the roots of Illigera luzonensis. | Phytochemistry 20110401 |
| Further SAR study on 11-O-substituted aporphine analogues: identification of highly potent dopamine D3 receptor ligands. | Bioorganic & medicinal chemistry 20110315 |
| Cytotoxic aporphine alkaloids from Ocotea acutifolia. | Planta medica 20110301 |
| New alkaloid antibiotics that target the DNA topoisomerase I of Streptococcus pneumoniae. | The Journal of biological chemistry 20110225 |
| Nantenine as an acetylcholinesterase inhibitor: SAR, enzyme kinetics and molecular modeling investigations. | Journal of enzyme inhibition and medicinal chemistry 20110201 |
| Antiplasmodial activity of aporphine alkaloids and sesquiterpene lactones from Liriodendron tulipifera L. | Journal of ethnopharmacology 20110107 |
| A call for using natural compounds in the development of new antimalarial treatments - an introduction. | Malaria journal 20110101 |
| A novel structural framework for α(1A/D)-adrenoceptor selective antagonists identified using subtype selective pharmacophores. | PloS one 20110101 |
| Liriodenine, early antimicrobial defence in Annona diversifolia. | Zeitschrift fur Naturforschung. C, Journal of biosciences 20110101 |
| Beyond THC: The New Generation of Cannabinoid Designer Drugs. | Frontiers in behavioral neuroscience 20110101 |
| Aqueous extract of Annona squamosa (L.) ameliorates renal failure induced by 5/6 nephrectomy in rat. | Indian journal of pharmacology 20110101 |
| Alkaloidal constituents of Tinospora crispa. | Natural product communications 20101101 |
| New cytotoxic tetrahydroprotoberberine-aporphine dimeric and aporphine alkaloids from Corydalis turtschaninovii. | Planta medica 20101001 |
| Anti-tubercular screening of natural products from Colombian plants: 3-methoxynordomesticine, an inhibitor of MurE ligase of Mycobacterium tuberculosis. | The Journal of antimicrobial chemotherapy 20101001 |
| Chemical investigation of drug-like compounds from the Australian tree, Neolitseadealbata. | Bioorganic & medicinal chemistry letters 20101001 |
| Isolation of chemical constituents from Enicosanthum cupulare (King) Airy-Shaw. | Natural product research 20101001 |
| Therapeutic Potential of Plants as Anti-microbials for Drug Discovery. | Evidence-based complementary and alternative medicine : eCAM 20100901 |
| Cytotoxic and antiviral activities of aporphine alkaloids of Magnolia grandiflora L. | Natural product research 20100901 |
| Aporphine alkaloids, clerodane diterpenes, and other constituents from Tinospora cordifolia. | Fitoterapia 20100901 |
| Aporphine alkaloids from the roots of Stephania viridiflavens. | Natural product research 20100801 |
| Alkaloids from Fissistigma latifolium (Dunal) Merr. | Molecules (Basel, Switzerland) 20100624 |
| In-vitro and in-vivo evaluations of cytochrome P450 1A2 interactions with nuciferine. | The Journal of pharmacy and pharmacology 20100501 |
| Aporphine and bisaporphine alkaloids from Aristolochia lagesiana var. intermedia. | Phytochemistry 20100301 |
| In vitro inhibitory activities of Lauraceae aporphine alkaloids. | Natural product communications 20100301 |
| Synthesis of dihydrofuroaporphine derivatives: identification of a potent and selective serotonin 5-HT 1A receptor agonist. | Journal of medicinal chemistry 20100211 |
| Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine. | Bioorganic & medicinal chemistry letters 20100115 |
| Recent N-atom containing compounds from indo-pacific invertebrates. | Marine drugs 20100101 |
| Biochemistry and occurrence of o-demethylation in plant metabolism. | Frontiers in physiology 20100101 |
| Evaluation of binding property of mucilage from Litsea glutinosa wall. | Pharmacognosy research 20100101 |
| Cytotoxic essential oil from Annona sengalensis Pers. leaves. | Pharmacognosy research 20100101 |
| The chemistry, pharmacologic, and therapeutic applications of Polyalthia longifolia. | Pharmacognosy reviews 20100101 |
| Boldine: a potential new antiproliferative drug against glioma cell lines. | Investigational new drugs 20091201 |
| Larvicidal activity against Aedes aegypti of some plants native to the West-Central region of Brazil. | Bioresource technology 20091201 |
| Inhibition of the human ether-a-go-go-related gene (HERG) K+ channels by Lindera erythrocarpa. | Journal of Korean medical science 20091201 |
| Bioactive constituents of the stem bark of Mitrephora glabra. | Journal of natural products 20091101 |
| Simultaneous characterization of quaternary alkaloids, 8-oxoprotoberberine alkaloids, and a steroid compound in Coscinium fenestratum by liquid chromatography hybrid ion trap time-of-flight mass spectrometry. | Journal of pharmaceutical and biomedical analysis 20091015 |
| The aporphine alkaloid boldine induces adiponectin expression and regulation in 3T3-L1 cells. | Journal of medicinal food 20091001 |
| [Aporphine alkaloids from branches and leaves of Polyalthia nemoralis]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090901 |
| Bioactive styryllactones and alkaloid from flowers of Goniothalamus laoticus. | Journal of ethnopharmacology 20090817 |
| Antimalarial benzylisoquinoline alkaloid from the rainforest tree Doryphora sassafras. | Journal of natural products 20090801 |
| Anti-Alzheimer and antioxidant activities of Coptidis Rhizoma alkaloids. | Biological & pharmaceutical bulletin 20090801 |
| (+)-N-(2-hydroxypropyl)lindcarpine: a new cytotoxic aporphine isolated from Actinodaphne pruinosa Nees. | Molecules (Basel, Switzerland) 20090731 |
| Photoreduction of oxoisoaporphines by amines: laser flash and steady-state photolysis, pulse radiolysis, and TD-DFT studies. | The journal of physical chemistry. A 20090709 |
| N-Substituted-2-alkyl- and 2-arylnorapomorphines: novel, highly active D2 agonists. | Bioorganic & medicinal chemistry 20090701 |
| Synthesis of aristolactam analogues and evaluation of their antitumor activity. | Bioorganic & medicinal chemistry letters 20090601 |
| Antifungal alkaloids from the fresh rattan stem of Fibraurea recisa Pierre. | Journal of ethnopharmacology 20090504 |
| (+/-)-Nantenine analogs as antagonists at human 5-HT(2A) receptors: C1 and flexible congeners. | Bioorganic & medicinal chemistry letters 20090501 |
| Aporphine alkaloids from Clematis parviloba and their antifungal activity. | Archives of pharmacal research 20090101 |
| Stilbene glycosides are natural product inhibitors of FGF-2-induced angiogenesis. | BMC cell biology 20090101 |
| Cholinesterase inhibitory and anti-amnesic activity of alkaloids from Corydalis turtschaninovii. | Journal of ethnopharmacology 20080902 |
| Cinnamoyl- and hydroxycinnamoyl amides of glaucine and their antioxidative and antiviral activities. | Bioorganic & medicinal chemistry 20080801 |
| Synthesis and binding studies of 2-O- and 11-O-substituted N-alkylnoraporphines. | Bioorganic & medicinal chemistry letters 20080715 |
| [HPLC determination of 2-hydroxy-1-methoxyaporphine, pronuciferine, nuciferine and roemerine in Nelumbo nucifera and its alkaloid fraction]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080701 |
| Evalution of anti-ulcer activity of Polyalthia longifolia (Sonn.) Thwaites in experimental animals. | Indian journal of pharmacology 20080601 |
| Vasorelaxing alkaloids and flavonoids from Cassytha filiformis. | Journal of natural products 20080201 |
| HPLC method for the pharmacokinetics and tissue distribution of taspine solution and taspine liposome after intravenous administrations to mice. | Journal of pharmaceutical and biomedical analysis 20080107 |
| New proaporphines from the bark of Phoebe scortechinii. | Natural product research 20080101 |
| Bioactive constituents of the roots of Polyalthia cerasoides. | Journal of natural products 20070901 |
| R-(-)-N-alkyl-11-hydroxy-10-hydroxymethyl- and 10-methyl-aporphines as 5-HT1A receptor ligands. | Bioorganic & medicinal chemistry letters 20070801 |
| An alkaloid, two conjugate sesquiterpenes and a phenylpropanoid from Pachypodanthium confine Engl. and Diels. | Phytochemistry 20070701 |
| [Studies on the aporphine alkaloids from Fissistigma oldhamii (Hemsl.) Merr]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20070401 |
| Anthelmintic activity of aporphine alkaloids from Cissampelos capensis. | Planta medica 20070301 |
| A new aporphine alkaloid from Sabia yunnanensis. | Natural product research 20070101 |
| Antiviral and antimicrobial profiles of selected isoquinoline alkaloids from Fumaria and Corydalis species. | Zeitschrift fur Naturforschung. C, Journal of biosciences 20070101 |
| Free radical scavenging activity and lipoxygenase inhibition of Mahonia aquifolium extract and isoquinoline alkaloids. | Journal of inflammation (London, England) 20070101 |
| Syntheses of aporphine and homoaporphine alkaloids by intramolecular ortho-arylation of phenols with aryl halides via SRN1 reactions in liquid ammonia. | The Journal of organic chemistry 20061027 |
| N-nitrosoanonaine and N-nitrosoxylopine, aporphine alkaloids from Duguetia furfuracea. | Journal of natural products 20060801 |
| Aporphine alkaloids and their reversal activity of multidrug resistance (MDR) from the stems and rhizomes of Sinomenium acutum. | Archives of pharmacal research 20060801 |
| Antinociceptive and free radical scavenging activities of alkaloids isolated from Lindera angustifolia Chen. | Journal of ethnopharmacology 20060719 |
| Antiplatelet activity of aporphine and phenanthrenoid alkaloids from Aromadendron elegans Blume. | Phytotherapy research : PTR 20060601 |
| Synthesis and dopamine receptor binding of sulfur-containing aporphines. | Bioorganic & medicinal chemistry 20060315 |
| Alkaloids from Eschscholzia californica and their capacity to inhibit binding of [3H]8-Hydroxy-2-(di-N-propylamino)tetralin to 5-HT1A receptors in Vitro. | Journal of natural products 20060301 |
| Astonishing diversity of natural surfactants: 6. Biologically active marine and terrestrial alkaloid glycosides. | Lipids 20051101 |
| 8-NH2-boldine, an antagonist of alpha1A and alpha1B adrenoceptors without affinity for the alpha1D subtype: structural requirements for aporphines at alpha1-adrenoceptor subtypes. | Planta medica 20051001 |
| [Alkaloids from the root of Lindera angustifolia]. | Yao xue xue bao = Acta pharmaceutica Sinica 20051001 |
| Structure-affinity relationships of halogenated predicentrine and glaucine derivatives at D1 and D2 dopaminergic receptors: halogenation and D1 receptor selectivity. | Bioorganic & medicinal chemistry 20050601 |
| Cytotoxic and antitumor potentialities of aporphinoid alkaloids. | Current medicinal chemistry. Anti-cancer agents 20050301 |
| Acetylated aporphine alkaloids from Lysichiton camtschatcense. | Journal of natural products 20050301 |
| Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure-activity correlations with related alkaloids. | Bioorganic & medicinal chemistry 20050117 |
| Thaliporphine increases survival rate and attenuates multiple organ injury in LPS-induced endotoxaemia. | Naunyn-Schmiedeberg's archives of pharmacology 20050101 |
| Simple method for identification of skeletons of aporphine alkaloids from 13C NMR data using artificial neural networks. | Journal of chemical information and modeling 20050101 |
| Direct intramolecular arylation of unactivated arenes: application to the synthesis of aporphine alkaloids. | Chemical communications (Cambridge, England) 20041221 |
| The vascular and cardioprotective effects of liriodenine in ischemia-reperfusion injury via NO-dependent pathway. | Nitric oxide : biology and chemistry 20041201 |
| Synthesis of phenanthrenes and polycyclic heteroarenes by transition-metal catalyzed cycloisomerization reactions. | Chemistry (Weinheim an der Bergstrasse, Germany) 20040920 |
| Development and validation of a high performance liquid chromatographic method for quantitative determination of aporphine alkaloids from different samples of Cassytha filiformis. | Planta medica 20040801 |
| Vascular activity of (-)-anonaine, (-)-roemerine and (-)-pukateine, three natural 6a(R)-1,2-methylenedioxyaporphines with different affinities for alpha1-adrenoceptor subtypes. | Planta medica 20040701 |
| Alkaloids from Delphinium pentagynum. | Phytochemistry 20040701 |
| Reactive oxygen species (ROS) generation inhibited by aporphine and phenanthrene alkaloids semi-synthesized from natural boldine. | Chemical & pharmaceutical bulletin 20040601 |
| Alkaloids from Cassytha filiformis and related aporphines: antitrypanosomal activity, cytotoxicity, and interaction with DNA and topoisomerases. | Planta medica 20040501 |
| A new alkaloid and its artificial derivative with an indazole ring from Nigella glandulifera. | Chemical & pharmaceutical bulletin 20040401 |
| A new oxoaporphine alkaloid from Sinofranchetia chinensis. | Fitoterapia 20040301 |
| Acute cardiovascular effects of (+)-nantenine, an alkaloid isolated from Platycapnos spicata, in anaesthetised normotensive rats. | Planta medica 20040201 |
| Key fragmentation patterns of aporphine alkaloids by electrospray ionization with multistage mass spectrometry. | Rapid communications in mass spectrometry : RCM 20040101 |
| Electrospray tandem mass spectrometry for structural characterization of aporphine- benzylisoquinoline alkaloids. | European journal of mass spectrometry (Chichester, England) 20040101 |
| Concise total synthesis of the aporphine alkaloid 7,7'-bisdehydro-O-methylisopiline by an InCl3 mediated cycloisomerization reaction. | Chemical communications (Cambridge, England) 20030907 |
| Constituents from the stems of Goniothalamus griffithii. | Planta medica 20030901 |
| Cytotoxic and DNA damaging activity of some aporphine alkaloids from Stephania dinklagei. | Planta medica 20030901 |
| Characterisation of alkaloids from some Australian Stephania (Menispermaceae) species. | Phytochemistry 20030701 |
| Aporphine alkaloids from Guatteria spp. with leishmanicidal activity. | Planta medica 20030701 |
| Nantenine blocks muscle contraction and Ca2+ transient induced by noradrenaline and K+ in rat vas deferens. | European journal of pharmacology 20030530 |
| Free-radical scavengers and antioxidants from Peumus boldus Mol. ('Boldo'). | Free radical research 20030401 |
| Antiplatelet activities of aporphine alkaloids isolated from leaves of Magnolia obovata. | Planta medica 20030301 |
| Effects of some antioxidative aporphine derivatives on striatal dopaminergic transmission and on MPTP-induced striatal dopamine depletion in B6CBA mice. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20030201 |
| Pharmacological effects of (+)-nantenine, an alkaloid isolated from Platycapnos spicata, in several rat isolated tissues. | Planta medica 20030201 |
| Lakshminine, a new rare oxoisoaporphine alkaloid from Sciadotenia toxifera, and structural revisions of telazoline and teladiazoline, two related oxoaporphines from Telitoxicum peruvianum and T. glaziovii. | Journal of natural products 20030101 |
| Behavioural evidence of agonist-like effect of isoteoline at 5-HT1B serotonergic receptors in mice. | The Journal of pharmacy and pharmacology 20030101 |
| Nantenine alkaloid presents anticonvulsant effect on two classical animal models. | Phytomedicine : international journal of phytotherapy and phytopharmacology 20030101 |
| Cytotoxic aporphine alkaloids from Cassytha filiformis. | Planta medica 20021101 |
| Sesquiterpenes and alkaloids from Lindera chunii and their inhibitory activities against HIV-1 integrase. | Chemical & pharmaceutical bulletin 20020901 |
| Affinity profile at alpha(1)- and alpha(2)-adrenoceptor subtypes and in vitro cardiovascular actions of (+)-boldine. | European journal of pharmacology 20020517 |
| Structure-activity relationship studies with (+/-)-nantenine derivatives for alpha1-adrenoceptor antagonist activity. | European journal of pharmacology 20020222 |
| Preliminary study of the vasorelaxant effects of (+)-nantenine, an alkaloid isolated from Platycapnos spicata, in rat aorta. | Planta medica 20011201 |
| Dimeric aporphine alkaloids of Phoenicanthus obliqua from Sri Lanka. | Journal of natural products 20011101 |
| Inhibition of platelet-activating factor receptor binding by aporphine and phenanthrenoid alkaloids from Aromadendron elegans. | Planta medica 20010701 |
| Chemopreventive activity of isoquinoline alkaloids from Corydalis plants. | Planta medica 20010701 |
| Mechanical effects of liriodenine on the left ventricular-arterial coupling in Wistar rats: pressure-stroke volume analysis. | British journal of pharmacology 20010501 |
| In vitro dose dependent inverse effect of nantenine on synaptosomal membrane K+-p-NPPase activity. | Phytomedicine : international journal of phytotherapy and phytopharmacology 20010301 |
| Serotonergic and dopaminergic activities of rigidified (R)-aporphine derivatives. | Bioorganic & medicinal chemistry letters 20010212 |
Related Products
© 2019 Angene International Limited. All rights Reserved.