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475-83-2 | Nuciferine
CAS No: 475-83-2 Catalog No: AG0035F4 MDL No:MFCD01664592
Product Description
Catalog Number:
AG0035F4
Chemical Name:
Nuciferine
CAS Number:
475-83-2
Molecular Formula:
C19H21NO2
Molecular Weight:
295.3755
MDL Number:
MFCD01664592
IUPAC Name:
(6aR)-1,2-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline
InChI:
InChI=1S/C19H21NO2/c1-20-9-8-13-11-16(21-2)19(22-3)18-14-7-5-4-6-12(14)10-15(20)17(13)18/h4-7,11,15H,8-10H2,1-3H3/t15-/m1/s1
InChI Key:
ORJVQPIHKOARKV-OAHLLOKOSA-N
SMILES:
COc1cc2CCN([C@H]3c2c(c1OC)c1ccccc1C3)C
UNII:
W26UEB90B7
Properties
Complexity:
401
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
1
Defined Bond Stereocenter Count:
0
Exact Mass:
295.157g/mol
Formal Charge:
0
Heavy Atom Count:
22
Hydrogen Bond Acceptor Count:
3
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
295.382g/mol
Monoisotopic Mass:
295.157g/mol
Rotatable Bond Count:
2
Topological Polar Surface Area:
21.7A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.4
Literature
| Title | Journal |
|---|---|
| Nuciferine stimulates insulin secretion from beta cells-an in vitro comparison with glibenclamide. | Journal of ethnopharmacology 20120713 |
| Characterization of nuciferine metabolism by P450 enzymes and uridine diphosphate glucuronosyltransferases in liver microsomes from humans and animals. | Acta pharmacologica Sinica 20101201 |
| Preparative separation of alkaloids from Nelumbo nucifera leaves by conventional and pH-zone-refining counter-current chromatography. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100601 |
| In-vitro and in-vivo evaluations of cytochrome P450 1A2 interactions with nuciferine. | The Journal of pharmacy and pharmacology 20100501 |
| [Optimal extraction of nuciferine and flavone from lotus leaf based on central composite design and response surface methodology]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20081001 |
| [HPLC determination of 2-hydroxy-1-methoxyaporphine, pronuciferine, nuciferine and roemerine in Nelumbo nucifera and its alkaloid fraction]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080701 |
| Antipoliovirus structure-activity relationships of some aporphine alkaloids. | Journal of natural products 19980401 |
| Psychopharmacological studies on (--)-nuciferine and its Hofmann degradation product atherosperminine. | Psychopharmacology 19780915 |
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