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CAS No: 4707-32-8 Catalog No: AG0038Q6 MDL No:MFCD01712233
Title | Journal |
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Human NAD(P)H:quinone oxidoreductase 1 (NQO1)-mediated inactivation of reactive quinoneimine metabolites of diclofenac and mefenamic acid. | Chemical research in toxicology 20140421 |
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. | Bioorganic & medicinal chemistry 20121115 |
Synthesis and structure-activity relationships of lapacho analogues. 1. Suppression of human keratinocyte hyperproliferation by 2-substituted naphtho[2,3-b]furan-4,9-diones, activation by enzymatic one- and two-electron reduction, and intracellular generation of superoxide. | Journal of medicinal chemistry 20120823 |
New oxirane derivatives of 1,4-naphthoquinones and their evaluation against T. cruzi epimastigote forms. | Bioorganic & medicinal chemistry 20120815 |
β-Lapachone analogs with enhanced antiproliferative activity. | European journal of medicinal chemistry 20120701 |
An NQO1 substrate with potent antitumor activity that selectively kills by PARP1-induced programmed necrosis. | Cancer research 20120615 |
On the search for potential anti-Trypanosoma cruzi drugs: synthesis and biological evaluation of 2-hydroxy-3-methylamino and 1,2,3-triazolic naphthoquinoidal compounds obtained by click chemistry reactions. | European journal of medicinal chemistry 20120601 |
Screening of anti-cancer agent using zebrafish: comparison with the MTT assay. | Biochemical and biophysical research communications 20120525 |
NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones. | Biochemical pharmacology 20120415 |
Prevention of salt-induced renal injury by activation of NAD(P)H:quinone oxidoreductase 1, associated with NADPH oxidase. | Free radical biology & medicine 20120301 |
Temperature-sensitive gels for intratumoral delivery of β-lapachone: effect of cyclodextrins and ethanol. | TheScientificWorldJournal 20120101 |
No role of homologous recombination in dealing with β-lapachone cytotoxicity in yeast. | Chemical research in toxicology 20111219 |
Preclinical genotoxicology of nor-β-lapachone in human cultured lymphocytes and Chinese hamster lung fibroblasts. | Chemical research in toxicology 20110919 |
Corpus cavernosal smooth muscle relaxation effect of a novel AMPK activator, beta-lapachone. | The journal of sexual medicine 20110801 |
Activation of NAD(P)H:quinone oxidoreductase ameliorates spontaneous hypertension in an animal model via modulation of eNOS activity. | Cardiovascular research 20110801 |
Synthesis and anti-Trypanosoma cruzi activity of β-lapachone analogues. | European journal of medicinal chemistry 20110701 |
β-lapachone accelerates the recovery of burn-wound skin. | Histology and histopathology 20110701 |
Identification of nor-β-lapachone derivatives as potential antibacterial compounds against Enterococcus faecalis clinical strain. | Current microbiology 20110201 |
β-Lapachone-induced reactive oxygen species (ROS) generation mediates autophagic cell death in glioma U87 MG cells. | Chemico-biological interactions 20110115 |
Modulating endogenous NQO1 levels identifies key regulatory mechanisms of action of β-lapachone for pancreatic cancer therapy. | Clinical cancer research : an official journal of the American Association for Cancer Research 20110115 |
Trypanosoma cruzi: insights into naphthoquinone effects on growth and proteinase activity. | Experimental parasitology 20110101 |
Hyperthermia enhances the effect of β-lapachone to cause γH2AX formations and cell death in human osteosarcoma cells. | International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20110101 |
Synthesis and evaluation of quinonoid compounds against tumor cell lines. | European journal of medicinal chemistry 20110101 |
Synthesis of biologically active (-)-dehydroiso-β-lapachone and the determination of its absolute configuration. | Chemical & pharmaceutical bulletin 20110101 |
Endoplasmic reticulum stress-induced JNK activation is a critical event leading to mitochondria-mediated cell death caused by β-lapachone treatment. | PloS one 20110101 |
β-Lapachone induces heart morphogenetic and functional defects by promoting the death of erythrocytes and the endocardium in zebrafish embryos. | Journal of biomedical science 20110101 |
β-lapachone significantly increases the effect of ionizing radiation to cause mitochondrial apoptosis via JNK activation in cancer cells. | PloS one 20110101 |
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
Prostate cancer radiosensitization through poly(ADP-Ribose) polymerase-1 hyperactivation. | Cancer research 20101015 |
Activity of β-lapachone derivatives against rifampicin-susceptible and -resistant strains of Mycobacterium tuberculosis. | Tuberculosis (Edinburgh, Scotland) 20100901 |
Synthesis of naturally occurring naphthoquinone epoxides and application in the synthesis of beta-lapachone. | Organic & biomolecular chemistry 20100821 |
Beta-lapachone suppresses radiation-induced activation of nuclear factor-kappaB. | Experimental & molecular medicine 20100531 |
Beta-lapachone micellar nanotherapeutics for non-small cell lung cancer therapy. | Cancer research 20100515 |
A naphthoquinone derivative can induce anemia through phosphatidylserine exposure-mediated erythrophagocytosis. | The Journal of pharmacology and experimental therapeutics 20100501 |
The evaluation of quinonoid compounds against Trypanosoma cruzi: synthesis of imidazolic anthraquinones, nor-beta-lapachone derivatives and beta-lapachone-based 1,2,3-triazoles. | Bioorganic & medicinal chemistry 20100501 |
Antifungal activity of the naphthoquinone beta-lapachone against disseminated infection with Cryptococcus neoformans var. neoformans in dexamethasone-immunosuppressed Swiss mice. | Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20100401 |
Antiproliferative activity of synthetic naphthoquinones related to lapachol. First synthesis of 5-hydroxylapachol. | Bioorganic & medicinal chemistry 20100401 |
Paclitaxel and beta-lapachone synergistically induce apoptosis in human retinoblastoma Y79 cells by downregulating the levels of phospho-Akt. | Journal of cellular physiology 20100201 |
Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors. | Bioorganic & medicinal chemistry letters 20091201 |
The trypanocidal activity of naphthoquinones: a review. | Molecules (Basel, Switzerland) 20091110 |
Cisplatin enhances the anticancer effect of beta-lapachone by upregulating NQO1. | Anti-cancer drugs 20091101 |
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. | Nature chemical biology 20091001 |
Toxicological assessment of beta-lapachone on organs from pregnant and non-pregnant rats. | Phytotherapy research : PTR 20090901 |
Synthesis and evaluation of bioactive naphthoquinones from the Brazilian medicinal plant, Tabebuia avellanedae. | Bioorganic & medicinal chemistry 20090901 |
In vitro synergic effect of beta-lapachone and isoniazid on the growth of Mycobacterium fortuitum and Mycobacterium smegmatis. | Memorias do Instituto Oswaldo Cruz 20090701 |
Activation of NAD(P)H:quinone oxidoreductase 1 prevents arterial restenosis by suppressing vascular smooth muscle cell proliferation. | Circulation research 20090410 |
Restenosis revisited. | Circulation research 20090410 |
Pharmacological stimulation of NADH oxidation ameliorates obesity and related phenotypes in mice. | Diabetes 20090401 |
Ex vivo activities of beta-lapachone and alpha-lapachone on macrophages: a quantitative pharmacological analysis based on amperometric monitoring of oxidative bursts by single cells. | Chembiochem : a European journal of chemical biology 20090213 |
Photosensitizing properties of triplet beta-lapachones in acetonitrile solution. | Photochemistry and photobiology 20090101 |
In vitro metabolism of beta-lapachone (ARQ 501) in mammalian hepatocytes and cultured human cells. | Rapid communications in mass spectrometry : RCM 20090101 |
Increased susceptibility of spinal muscular atrophy fibroblasts to camptothecin is p53-independent. | BMC cell biology 20090101 |
Heat shock increases expression of NAD(P)H:quinone oxidoreductase (NQO1), mediator of beta-lapachone cytotoxicity, by increasing NQO1 gene activity and via Hsp70-mediated stabilisation of NQO1 protein. | International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20090101 |
Modulatory effects of Tabebuia impetiginosa (Lamiales, Bignoniaceae) on doxorubicin-induced somatic mutation and recombination in Drosophila melanogaster. | Genetics and molecular biology 20090101 |
Involvement of endoplasmic reticulum stress and activation of MAP kinases in beta-lapachone-induced human prostate cancer cell apoptosis. | Histology and histopathology 20081101 |
Semisynthesis and antitumoral activity of 2-acetylfuranonaphthoquinone and other naphthoquinone derivatives from lapachol. | Bioorganic & medicinal chemistry letters 20081015 |
Inner reorganization during the radical-biradical transition in a nor-beta-lapachone derivative possessing two redox centers. | Organic & biomolecular chemistry 20080921 |
Development and validation of a liquid chromatography-tandem mass spectrometry method for the determination of ARQ 501 (beta-lapachone) in plasma and tumors from nu/nu mouse xenografts. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080901 |
Inactivation of the SMN complex by oxidative stress. | Molecular cell 20080725 |
Identification of the in vitro metabolites of 3,4-dihydro-2,2-dimethyl-2H-naphthol[1,2-b]pyran-5,6-dione (ARQ 501; beta-lapachone) in whole blood. | Drug metabolism and disposition: the biological fate of chemicals 20080401 |
Identification of a novel glucosylsulfate conjugate as a metabolite of 3,4-dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione (ARQ 501, beta-lapachone) in mammals. | Drug metabolism and disposition: the biological fate of chemicals 20080401 |
Laser flash photolysis study of the triplet reactivity of beta-lapachones. | Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20080401 |
Beta-lapachone inhibits proliferation and induces apoptosis in retinoblastoma cell lines. | Eye (London, England) 20080301 |
Anti-cancer effect of bio-reductive drug beta-lapachon is enhanced by activating NQO1 with heat shock. | International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20080301 |
Topoisomerase inhibitors as anti-arthritic agents. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20080301 |
Trypanosoma cruzi: activities of lapachol and alpha- and beta-lapachone derivatives against epimastigote and trypomastigote forms. | Bioorganic & medicinal chemistry 20080115 |
Compatibility of the antitumoral beta-lapachone with different solid dosage forms excipients. | Journal of pharmaceutical and biomedical analysis 20071130 |
Beta-lapachone-containing PEG-PLA polymer micelles as novel nanotherapeutics against NQO1-overexpressing tumor cells. | Journal of controlled release : official journal of the Controlled Release Society 20071008 |
Induction of Egr-1 is associated with anti-metastatic and anti-invasive ability of beta-lapachone in human hepatocarcinoma cells. | Bioscience, biotechnology, and biochemistry 20070901 |
Upregulation of NAD(P)H:quinone oxidoreductase by radiation potentiates the effect of bioreductive beta-lapachone on cancer cells. | Neoplasia (New York, N.Y.) 20070801 |
Nonhomologous end joining is essential for cellular resistance to the novel antitumor agent, beta-lapachone. | Cancer research 20070715 |
Applications of counter-current chromatography in organic synthesis purification of heterocyclic derivatives of lapachol. | Journal of chromatography. A 20070601 |
Involvement of NO/cGMP signaling in the apoptotic and anti-angiogenic effects of beta-lapachone on endothelial cells in vitro. | Journal of cellular physiology 20070501 |
Anti-inflammatory effects of beta-lapachone in lipopolysaccharide-stimulated BV2 microglia. | International immunopharmacology 20070401 |
Synthesis and pharmacophore modeling of naphthoquinone derivatives with cytotoxic activity in human promyelocytic leukemia HL-60 cell line. | Journal of medicinal chemistry 20070222 |
Calcium-dependent modulation of poly(ADP-ribose) polymerase-1 alters cellular metabolism and DNA repair. | The Journal of biological chemistry 20061103 |
Beta-lapachone activates a Mre11p-Tel1p G1/S checkpoint in budding yeast. | Cell cycle (Georgetown, Tex.) 20061101 |
Modulating beta-lapachone release from polymer millirods through cyclodextrin complexation. | Journal of pharmaceutical sciences 20061001 |
Oxyrane derivative of alpha-lapachone is potent growth inhibitor of Trypanosoma cruzi epimastigote forms. | Parasitology research 20060901 |
Synergistic effects of radiation and beta-lapachone in DU-145 human prostate cancer cells in vitro. | Radiation research 20060501 |
Preparation of alpha-diazocarbonyl compounds from beta-lapachone derivatives and other 1,2-naphthoquinones: use of the 2D NMR 1H,15N and 1H,13C HMBC techniques in assigning regiochemistry. | Magnetic resonance in chemistry : MRC 20060401 |
beta-lapachone induces growth inhibition and apoptosis in bladder cancer cells by modulation of Bcl-2 family and activation of caspases. | Experimental oncology 20060301 |
Beta-lapachone, a quinone isolated from Tabebuia avellanedae, induces apoptosis in HepG2 hepatoma cell line through induction of Bax and activation of caspase. | Journal of medicinal food 20060101 |
Heat-induced up-regulation of NAD(P)H:quinone oxidoreductase potentiates anticancer effects of beta-lapachone. | Clinical cancer research : an official journal of the American Association for Cancer Research 20051215 |
Effect of a beta-lapachone-derived naphthoimidazole on Trypanosoma cruzi: identification of target organelles. | The Journal of antimicrobial chemotherapy 20051201 |
Development of beta-lapachone prodrugs for therapy against human cancer cells with elevated NAD(P)H:quinone oxidoreductase 1 levels. | Clinical cancer research : an official journal of the American Association for Cancer Research 20050415 |
Growth inhibition of A549 human lung carcinoma cells by beta-lapachone through induction of apoptosis and inhibition of telomerase activity. | International journal of oncology 20050401 |
Antiplasmodial activity of naphthoquinones related to lapachol and beta-lapachone. | Chemistry & biodiversity 20050201 |
Susceptibility of cancer cells to beta-lapachone is enhanced by ionizing radiation. | International journal of radiation oncology, biology, physics 20050101 |
Efficacy of beta-lapachone in pancreatic cancer treatment: exploiting the novel, therapeutic target NQO1. | Cancer biology & therapy 20050101 |
2-Phenyl-beta-lapachone can affect mitochondrial function by redox cycling mediated oxidation. | Archives of biochemistry and biophysics 20041215 |
Alkaline-earth cations enhance ortho-quinone-catalyzed ascorbate oxidation. | Free radical biology & medicine 20041115 |
Effect of chemopreventive agents on glutathione S-transferase P1-1 gene expression mechanisms via activating protein 1 and nuclear factor kappaB inhibition. | Biochemical pharmacology 20040915 |
Studies on the trypanocidal activity of semi-synthetic pyran[b-4,3]naphtho[1,2-d]imidazoles from beta-lapachone. | European journal of medicinal chemistry 20040701 |
Cyr61 expression confers resistance to apoptosis in breast cancer MCF-7 cells by a mechanism of NF-kappaB-dependent XIAP up-regulation. | The Journal of biological chemistry 20040604 |
Antimalarial activity of phenazines from lapachol, beta-lapachone and its derivatives against Plasmodium falciparum in vitro and Plasmodium berghei in vivo. | Bioorganic & medicinal chemistry letters 20040308 |
beta-Lapachone-induced apoptosis is associated with activation of caspase-3 and inactivation of NF-kappaB in human colon cancer HCT-116 cells. | Anti-cancer drugs 20031101 |
Enhancement of solubility and bioavailability of beta-lapachone using cyclodextrin inclusion complexes. | Pharmaceutical research 20031001 |
beta-Lapachone reduces endotoxin-induced macrophage activation and lung edema and mortality. | American journal of respiratory and critical care medicine 20030701 |
Inhibitory effects of lapachol derivatives on epstein-barr virus activation. | Bioorganic & medicinal chemistry 20030220 |
Mu-calpain activation in beta-lapachone-mediated apoptosis. | Cancer biology & therapy 20030101 |
Calpains can do it alone: implications for cancer therapy. | Cancer biology & therapy 20030101 |
Toxic potential of dietary genistein isoflavone and beta-lapachone on capacitation and acrosome reaction of epididymal spermatozoa. | Journal of medicinal food 20030101 |
Cancer therapy with beta-lapachone. | Current cancer drug targets 20020901 |
Studies on fertilization in the teleost IV. Effects of aphidicolin and camptothecin on chromosome formation in fertilized medaka eggs. | Development, growth & differentiation 20020801 |
Effect of the lipophilic o-naphthoquinone CG 10-248 on rat liver mitochondria structure and function. | Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al 20020801 |
Inhibition of poly(ADP-ribose) polymerase activation attenuates beta-lapachone-induced necrotic cell death in human osteosarcoma cells. | Toxicology and applied pharmacology 20020715 |
beta-lapachone, a novel plant product, overcomes drug resistance in human multiple myeloma cells. | Experimental hematology 20020701 |
Reduction of lapachones and their reaction with L-cysteine and mercaptoethanol on glassy carbon electrodes. | Bioelectrochemistry (Amsterdam, Netherlands) 20020515 |
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
Chemosensitivity of human prostate cancer cells PC3 and LNCaP to genistein isoflavone and beta-lapachone. | Biology of the cell 20020201 |
Preparation and cytotoxicity toward cancer cells of mono(arylimino) derivatives of beta-lapachone. | Journal of medicinal chemistry 20010719 |
beta-Lapachone-induced apoptosis in human prostate cancer cells: involvement of NQO1/xip3. | Experimental cell research 20010701 |
Characterization of poly(ADP-ribose)polymerase from Crithidia fasciculata: enzyme inhibition by beta-lapachone. | Molecular and biochemical parasitology 20010701 |
Calcium is a key signaling molecule in beta-lapachone-mediated cell death. | The Journal of biological chemistry 20010601 |
Induction of CDK inhibitors (p21(WAF1) and p27(Kip1)) and Bak in the beta-lapachone-induced apoptosis of human prostate cancer cells. | Molecular pharmacology 20010401 |
Effect of dyskinetoplastic agents on ultrastructure and oxidative phosphorylation in Crithidia fasciculata. | Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al 20010401 |
Novel mechanism of cellular DNA topoisomerase II inhibition by the pyranonaphthoquinone derivatives alpha-lapachone and beta-lapachone. | Cancer chemotherapy and pharmacology 20010301 |
p53-independent upregulation of KILLER/DR5 TRAIL receptor expression by glucocorticoids and interferon-gamma. | Experimental cell research 20010115 |
[Cytotoxicity of beta-lapachone, an naphthoquinone with possible therapeutic use]. | Medicina 20010101 |
Comparison of antibacterial and antifungal activities of lapachol and beta-lapachone. | Planta medica 19940801 |
Three inhibitors of type 1 human immunodeficiency virus long terminal repeat-directed gene expression and virus replication. | Proceedings of the National Academy of Sciences of the United States of America 19930301 |
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