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4670-05-7 | Theaflavine
CAS No: 4670-05-7 Catalog No: AG003URO MDL No:MFCD03427500
Product Description
Catalog Number:
AG003URO
Chemical Name:
Theaflavine
CAS Number:
4670-05-7
Molecular Formula:
C29H24O12
Molecular Weight:
564.4937
MDL Number:
MFCD03427500
IUPAC Name:
3,4,6-trihydroxy-1,8-bis[(2R,3R)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-2-yl]benzo[7]annulen-5-one
InChI:
InChI=1S/C29H24O12/c30-11-3-17(32)15-8-21(36)28(40-23(15)5-11)10-1-13-14(7-20(35)27(39)25(13)26(38)19(34)2-10)29-22(37)9-16-18(33)4-12(31)6-24(16)41-29/h1-7,21-22,28-33,35-37,39H,8-9H2,(H,34,38)/t21-,22-,28-,29-/m1/s1
InChI Key:
IPMYMEWFZKHGAX-ZKSIBHASSA-N
SMILES:
Oc1cc2O[C@@H]([C@@H](Cc2c(c1)O)O)c1cc2c(cc(c(c2c(=O)c(c1)O)O)O)[C@H]1Oc2cc(O)cc(c2C[C@H]1O)O
UNII:
1IA46M0D13
Properties
Complexity:
1060
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
4
Defined Bond Stereocenter Count:
0
Exact Mass:
564.127g/mol
Formal Charge:
0
Heavy Atom Count:
41
Hydrogen Bond Acceptor Count:
12
Hydrogen Bond Donor Count:
9
Isotope Atom Count:
0
Molecular Weight:
564.499g/mol
Monoisotopic Mass:
564.127g/mol
Rotatable Bond Count:
2
Topological Polar Surface Area:
218A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.4
Literature
| Title | Journal |
|---|---|
| Tea polyphenols EGCG and TF restrict tongue and liver carcinogenesis simultaneously induced by N-nitrosodiethylamine in mice. | Toxicology and applied pharmacology 20160601 |
| Antifungal synergy of theaflavin and epicatechin combinations against Candida albicans. | Journal of microbiology and biotechnology 20130928 |
| Synthesis of PLGA nanoparticles of tea polyphenols and their strong in vivo protective effect against chemically induced DNA damage. | International journal of nanomedicine 20130101 |
| Intake estimation of total and individual flavan-3-ols, proanthocyanidins and theaflavins, their food sources and determinants in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. | The British journal of nutrition 20120928 |
| Theaflavin ameliorates behavioral deficits, biochemical indices and monoamine transporters expression against subacute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of Parkinson's disease. | Neuroscience 20120830 |
| Theaflavins inhibit the ATP synthase and the respiratory chain without increasing superoxide production. | The Journal of nutritional biochemistry 20120801 |
| Black tea polyphenols induce human leukemic cell cycle arrest by inhibiting Akt signaling: possible involvement of Hsp90, Wnt/β-catenin signaling and FOXO1. | The FEBS journal 20120801 |
| In vitro anti-influenza virus and anti-inflammatory activities of theaflavin derivatives. | Antiviral research 20120601 |
| [Adsorption dynamics study on interactions of pigments and human whole saliva]. | Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology 20120601 |
| Protective effect of theaflavins on homocysteine-induced injury in HUVEC cells in vitro. | Journal of cardiovascular pharmacology 20120501 |
| Effects of green tea or Sasa quelpaertensis bamboo leaves on plasma and liver lipids, erythrocyte Na efflux, and platelet aggregation in ovariectomized rats. | Nutrition research and practice 20120401 |
| A natural theaflavins preparation inhibits HIV-1 infection by targeting the entry step: potential applications for preventing HIV-1 infection. | Fitoterapia 20120301 |
| Black tea polyphenols inhibit tumor proteasome activity. | In vivo (Athens, Greece) 20120301 |
| Protective effect of theaflavins on neuron against 6-hydroxydopamine-induced apoptosis in SH-SY5Y cells. | Journal of clinical biochemistry and nutrition 20120301 |
| Theaflavins extracted from black tea inhibit airway mucous hypersecretion induced by cigarette smoke in rats. | Inflammation 20120201 |
| Dietary flavan-3-ols intake and metabolic syndrome risk in Korean adults. | Nutrition research and practice 20120201 |
| Theaflavin, a black tea polyphenol, protects nigral dopaminergic neurons against chronic MPTP/probenecid induced Parkinson's disease. | Brain research 20120118 |
| Theaflavin attenuates ischemia-reperfusion injury in a mouse fatty liver model. | Biochemical and biophysical research communications 20120106 |
| Impact of nanotechnology in cancer: emphasis on nanochemoprevention. | International journal of nanomedicine 20120101 |
| Antibacterial and antifungal activities of new acylated derivatives of epigallocatechin gallate. | Frontiers in microbiology 20120101 |
| Heme oxygenase, inflammation, and fibrosis: the good, the bad, and the ugly? | Frontiers in pharmacology 20120101 |
| Black tea theaflavins inhibit formation of toxic amyloid-β and α-synuclein fibrils. | Biochemistry 20111213 |
| Neuroprotective effects of white tea against oxidative stress-induced toxicity in striatal cells. | Neurotoxicity research 20111101 |
| Antibacterial effects of theaflavin and synergy with epicatechin against clinical isolates of Acinetobacter baumannii and Stenotrophomonas maltophilia. | International journal of antimicrobial agents 20111101 |
| Structural identification of mouse fecal metabolites of theaflavin 3,3'-digallate using liquid chromatography tandem mass spectrometry. | Journal of chromatography. A 20111014 |
| Effects of enzymatic action on the formation of theabrownin during solid state fermentation of Pu-erh tea. | Journal of the science of food and agriculture 20111001 |
| Development and evaluation of a spiral tube column for counter-current chromatography. | Journal of separation science 20111001 |
| Evaluation of the antioxidant effects of four main theaflavin derivatives through chemiluminescence and DNA damage analyses. | Journal of Zhejiang University. Science. B 20110901 |
| The chemistry and biotransformation of tea constituents. | Pharmacological research 20110801 |
| Theaflavin Inhibits LPS-Induced IL-6, MCP-1, and ICAM-1 Expression in Bone Marrow-Derived Macrophages Through the Blockade of NF-κB and MAPK Signaling Pathways. | Chonnam medical journal 20110801 |
| ATP-dependent potassium channels and mitochondrial permeability transition pores play roles in the cardioprotection of theaflavin in young rat. | The journal of physiological sciences : JPS 20110701 |
| Black tea and theaflavins suppress various inflammatory modulators and i-NOS mediated nitric oxide synthesis during gastric ulcer healing. | Free radical research 20110701 |
| Black tea polyphenol inhibits CXCL10 production in oncostatin M-stimulated human gingival fibroblasts. | International immunopharmacology 20110601 |
| Characterization of tea cultivated at four different altitudes using 1H NMR analysis coupled with multivariate statistics. | Journal of agricultural and food chemistry 20110525 |
| Black tea polyphenol theaflavin suppresses LPS-induced ICAM-1 and VCAM-1 expression via blockage of NF-κB and JNK activation in intestinal epithelial cells. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20110501 |
| Molecular binding of black tea theaflavins to biological membranes: relationship to bioactivities. | Journal of agricultural and food chemistry 20110427 |
| Diverse inhibition of plasminogen activator inhibitor type 1 by theaflavins of black tea. | International journal of molecular medicine 20110401 |
| Theaflavins depolymerize microtubule network through tubulin binding and cause apoptosis of cervical carcinoma HeLa cells. | Journal of agricultural and food chemistry 20110309 |
| Affinity interactions between natural pigments and human whole saliva. | Archives of oral biology 20110301 |
| Effects of the black tea polyphenol theaflavin-2 on apoptotic and inflammatory pathways in vitro and in vivo. | Molecular nutrition & food research 20110201 |
| [Adsorption kinetic study of the interaction between human salivary alpha-amylase and the polyphenoles from the black/green tea]. | Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology 20110201 |
| Targeting PML-RARα and Oncogenic Signaling Pathways by Chinese Herbal Mixture Tien-Hsien Liquid in Acute Promyelocytic Leukemia NB4 Cells. | Evidence-based complementary and alternative medicine : eCAM 20110101 |
| The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease. | International journal of molecular sciences 20110101 |
| The inhibition of the mammalian DNA methyltransferase 3a (Dnmt3a) by dietary black tea and coffee polyphenols. | BMC biochemistry 20110101 |
| Sesamin ameliorates oxidative stress and mortality in kainic acid-induced status epilepticus by inhibition of MAPK and COX-2 activation. | Journal of neuroinflammation 20110101 |
| Changes of constituents and activity to apoptosis and cell cycle during fermentation of tea. | International journal of molecular sciences 20110101 |
| Research strategies in the study of the pro-oxidant nature of polyphenol nutraceuticals. | Journal of toxicology 20110101 |
| Tea polyphenols induce apoptosis through mitochondrial pathway and by inhibiting nuclear factor-kappaB and Akt activation in human cervical cancer cells. | Oncology research 20110101 |
| Variations of antioxidant properties and NO scavenging abilities during fermentation of tea. | International journal of molecular sciences 20110101 |
| Comparative antimutagenic and anticancer activity of three fractions of black tea polyphenols thearubigins. | Nutrition and cancer 20110101 |
| Biomedical potential of silver nanoparticles synthesized from calli cells of Citrullus colocynthis (L.) Schrad. | Journal of nanobiotechnology 20110101 |
| Black tea extract prevents lipopolysaccharide-induced NF-κB signaling and attenuates dextran sulfate sodium-induced experimental colitis. | BMC complementary and alternative medicine 20110101 |
| Pu-Erh tea and GABA attenuates oxidative stress in kainic acid-induced status epilepticus. | Journal of biomedical science 20110101 |
| Antioxidant and antibacterial properties of green, black, and herbal teas of Camellia sinensis. | Pharmacognosy research 20110101 |
| Chemistry and biochemistry of dietary polyphenols. | Nutrients 20101201 |
| Oxidative cascade reactions yielding polyhydroxy-theaflavins and theacitrins in the formation of black tea thearubigins: evidence by tandem LC-MS. | Food & function 20101101 |
| Preventive effects of black tea theaflavins against mouse type IV allergy. | Journal of the science of food and agriculture 20100901 |
| Black-tea polyphenols decrease micellar solubility of cholesterol in vitro and intestinal absorption of cholesterol in rats. | Journal of agricultural and food chemistry 20100811 |
| Substrate specificity of the mitochondrial thioredoxin reductase of the parasitic nematode Haemonchus contortus. | Parasitology research 20100701 |
| Black tea polyphenols-mediated in vivo cellular responses during carcinogenesis. | Mini reviews in medicinal chemistry 20100601 |
| Synergistic effects of tea polyphenols and ascorbic acid on human lung adenocarcinoma SPC-A-1 cells. | Journal of Zhejiang University. Science. B 20100601 |
| Specific dietary polyphenols attenuate atherosclerosis in apolipoprotein E-knockout mice by alleviating inflammation and endothelial dysfunction. | Arteriosclerosis, thrombosis, and vascular biology 20100401 |
| Purified black tea theaflavins and theaflavins/catechin supplements did not affect serum lipids in healthy individuals with mildly to moderately elevated cholesterol concentrations. | European journal of nutrition 20100201 |
| Theaflavins target Fas/caspase-8 and Akt/pBad pathways to induce apoptosis in p53-mutated human breast cancer cells. | Carcinogenesis 20100201 |
| Theaflavins retard human breast cancer cell migration by inhibiting NF-kappaB via p53-ROS cross-talk. | FEBS letters 20100104 |
| Reaction of the black tea pigment theaflavin during enzymatic oxidation of tea catechins. | Journal of natural products 20100101 |
| The total antioxidant content of more than 3100 foods, beverages, spices, herbs and supplements used worldwide. | Nutrition journal 20100101 |
| Chemistry of secondary polyphenols produced during processing of tea and selected foods. | International journal of molecular sciences 20100101 |
| The effects of theaflavin-enriched black tea extract on muscle soreness, oxidative stress, inflammation, and endocrine responses to acute anaerobic interval training: a randomized, double-blind, crossover study. | Journal of the International Society of Sports Nutrition 20100101 |
| Impact of dietary polyphenols on carbohydrate metabolism. | International journal of molecular sciences 20100101 |
| Black tea polyphenol (theaflavin) downregulates MMP-2 in human melanoma cell line A375 by involving multiple regulatory molecules. | Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20100101 |
| Green tea catechin, epigallocatechin gallate, suppresses signaling by the dsRNA innate immune receptor RIG-I. | PloS one 20100101 |
| Regulators of G-Protein signaling RGS10 and RGS17 regulate chemoresistance in ovarian cancer cells. | Molecular cancer 20100101 |
| Novel screening method for potential skin-whitening compounds by a luciferase reporter assay. | Bioscience, biotechnology, and biochemistry 20100101 |
| Traditional herbal medicine in far-west Nepal: a pharmacological appraisal. | Journal of ethnobiology and ethnomedicine 20100101 |
| Preventive but not curative efficacy of celecoxib on bladder carcinogenesis in a rat model. | Mediators of inflammation 20100101 |
| The role of lipid and carbohydrate digestive enzyme inhibitors in the management of obesity: a review of current and emerging therapeutic agents. | Diabetes, metabolic syndrome and obesity : targets and therapy 20100101 |
| Alternative perspectives: how chinese medicine understands hypercholesterolemia. | Cholesterol 20100101 |
| The inhibitory effect of Camellia sinensis extracts against the neuromuscular blockade of Crotalus durissus terrificus venom. | Journal of venom research 20100101 |
| 1,1-Diphenyl-2-picrylhydrazyl radical and superoxide anion scavenging activity of Rhizophora mangle (L.) bark. | Pharmacognosy research 20100101 |
| Assessment of Immunomodulatory Activity of Euphorbia hirta L. | Indian journal of pharmaceutical sciences 20100101 |
| Role of oxidation-triggered activation of JNK and p38 MAPK in black tea polyphenols induced apoptotic death of A375 cells. | Cancer science 20091001 |
| Layer-by-Layer-Coated Gelatin Nanoparticles as a Vehicle for Delivery of Natural Polyphenols. | ACS nano 20090728 |
| Increase of theaflavin gallates and thearubigins by acceleration of catechin oxidation in a new fermented tea product obtained by the tea-rolling processing of loquat ( Eriobotrya japonica ) and green tea leaves. | Journal of agricultural and food chemistry 20090708 |
| Effects of theaflavins on melanin biosynthesis in mouse b16 melanoma cells. | Bioscience, biotechnology, and biochemistry 20090601 |
| Tea polyphenols can restrict benzo[a]pyrene-induced lung carcinogenesis by altered expression of p53-associated genes and H-ras, c-myc and cyclin D1. | The Journal of nutritional biochemistry 20090501 |
| Choice of DMEM, formulated with or without pyruvate, plays an important role in assessing the in vitro cytotoxicity of oxidants and prooxidant nutraceuticals. | In vitro cellular & developmental biology. Animal 20090101 |
| The protective effects of green tea extract against L-arginine toxicity to cultured human mesangial cells. | Journal of Korean medical science 20090101 |
| Antifungal activity of black tea polyphenols (catechins and theaflavins) against Candida species. | Chemotherapy 20090101 |
| [Effects of theaflavins on the signal transduction pathway of epidermal growth factor receptor in airway mucous hypersecretion]. | Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20090101 |
| Effects of apple juice on risk factors of lipid profile, inflammation and coagulation, endothelial markers and atherosclerotic lesions in high cholesterolemic rabbits. | Lipids in health and disease 20090101 |
| Tumor-shed PGE(2) impairs IL2Rgammac-signaling to inhibit CD4 T cell survival: regulation by theaflavins. | PloS one 20090101 |
| Polyphenols action against oxidative stress formation in endothelial cells. | Acta poloniae pharmaceutica 20090101 |
| Increased responsiveness of human coronary artery endothelial cells in inflammation and coagulation. | Mediators of inflammation 20090101 |
| Plant polyphenols as dietary antioxidants in human health and disease. | Oxidative medicine and cellular longevity 20090101 |
| PCR differential display-based identification of regulator of G protein signaling 10 as the target gene in human colon cancer cells induced by black tea polyphenol theaflavin monogallate. | European journal of pharmacology 20081228 |
| Theaflavins from black tea, especially theaflavin-3-gallate, reduce the incorporation of cholesterol into mixed micelles. | Journal of agricultural and food chemistry 20081224 |
| New phenolic components and chromatographic profiles of green and fermented teas. | Journal of agricultural and food chemistry 20080910 |
| Radical-scavenging abilities and antioxidant properties of theaflavins and their gallate esters in H2O2-mediated oxidative damage system in the HPF-1 cells. | Toxicology in vitro : an international journal published in association with BIBRA 20080801 |
| Theaflavin-3-gallate and theaflavin-3'-gallate, polyphenols in black tea with prooxidant properties. | Basic & clinical pharmacology & toxicology 20080701 |
| Inhibitory mechanisms of flavonoids on insulin-stimulated glucose uptake in MC3T3-G2/PA6 adipose cells. | Biological & pharmaceutical bulletin 20080701 |
| Contribution of p53-mediated Bax transactivation in theaflavin-induced mammary epithelial carcinoma cell apoptosis. | Apoptosis : an international journal on programmed cell death 20080601 |
| Preparative isolation and purification of theaflavins and catechins by high-speed countercurrent chromatography. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080515 |
| Polymer-like polyphenols of black tea and their lipase and amylase inhibitory activities. | Chemical & pharmaceutical bulletin 20080301 |
| Identification of a PKCepsilon-dependent regulation of myocardial contraction by epicatechin-3-gallate. | American journal of physiology. Heart and circulatory physiology 20080101 |
| Black tea polyphenols mimic insulin/insulin-like growth factor-1 signalling to the longevity factor FOXO1a. | Aging cell 20080101 |
| Combination of HSCCC and Sephadex LH-20 methods An approach to isolation and purification of the main individual theaflavins from black tea. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080101 |
| Monitoring the binding processes of black tea thearubigin to the bovine serum albumin surface using quartz crystal microbalance with dissipation monitoring. | Journal of agricultural and food chemistry 20071212 |
| Inhibitory effects of various beverages on human recombinant sulfotransferase isoforms SULT1A1 and SULT1A3. | Biopharmaceutics & drug disposition 20071201 |
| Theaflavins attenuate hepatic lipid accumulation through activating AMPK in human HepG2 cells. | Journal of lipid research 20071101 |
| Theaflavins induce G2/M arrest by modulating expression of p21waf1/cip1, cdc25C and cyclin B in human prostate carcinoma PC-3 cells. | Life sciences 20071013 |
| Determination of theaflavins including methylated theaflavins in black tea leaves by solid-phase extraction and HPLC analysis. | Journal of agricultural and food chemistry 20070905 |
| Inhibition of 17alpha-hydroxylase/C17,20-lyase (CYP17) from rat testis by green tea catechins and black tea theaflavins. | Bioscience, biotechnology, and biochemistry 20070901 |
| Inhibitory activities of dietary phenolic compounds on heterocyclic amine formation in both chemical model system and beef patties. | Molecular nutrition & food research 20070801 |
| Effects of infusion time and addition of milk on content and absorption of polyphenols from black tea. | Journal of agricultural and food chemistry 20070613 |
| Theaflavins induced apoptosis of LNCaP cells is mediated through induction of p53, down-regulation of NF-kappa B and mitogen-activated protein kinases pathways. | Life sciences 20070516 |
| Breast cancer prevention by green tea catechins and black tea theaflavins in the C3(1) SV40 T,t antigen transgenic mouse model is accompanied by increased apoptosis and a decrease in oxidative DNA adducts. | Journal of agricultural and food chemistry 20070502 |
| Structure-activity relationships of tea compounds against human cancer cells. | Journal of agricultural and food chemistry 20070124 |
| Theanaphthoquinone inhibits fatty acid synthase expression in EGF-stimulated human breast cancer cells via the regulation of EGFR/ErbB-2 signaling. | Toxicology and applied pharmacology 20070115 |
| alpha-Glucosidase inhibitory profile of catechins and theaflavins. | Journal of agricultural and food chemistry 20070110 |
| Comparison of plants used for skin and stomach problems in Trinidad and Tobago with Asian ethnomedicine. | Journal of ethnobiology and ethnomedicine 20070101 |
| Modulation of the oxidative stress and nuclear factor kappaB activation by theaflavin 3,3'-gallate in the rats exposed to cerebral ischemia-reperfusion. | Folia biologica 20070101 |
| Effects of a combination of thyme and oregano essential oils on TNBS-induced colitis in mice. | Mediators of inflammation 20070101 |
| Trapping reactions of reactive carbonyl species with tea polyphenols in simulated physiological conditions. | Molecular nutrition & food research 20061201 |
| High-throughput analysis of catechins and theaflavins by high performance liquid chromatography with diode array detection. | Journal of chromatography. A 20061103 |
| [Simultaneous analysis of theaflavins and catechins by capillary electrophoresis]. | Se pu = Chinese journal of chromatography 20061101 |
| In vitro cytotoxicity of a theaflavin mixture from black tea to malignant, immortalized, and normal cells from the human oral cavity. | Toxicology in vitro : an international journal published in association with BIBRA 20060801 |
| Anticlastogenic effects of black tea polyphenols theaflavins and thearubigins in human lymphocytes in vitro. | Toxicology in vitro : an international journal published in association with BIBRA 20060801 |
| Chemopreventive potential of diallylsulfide, lycopene and theaflavin during chemically induced colon carcinogenesis in rat colon through modulation of cyclooxygenase-2 and inducible nitric oxide synthase pathways. | European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 20060801 |
| Molecular and cellular targets. | Molecular carcinogenesis 20060601 |
| Epicatechins Purified from Green Tea (Camellia sinensis) Differentially Suppress Growth of Gender-Dependent Human Cancer Cell Lines. | Evidence-based complementary and alternative medicine : eCAM 20060601 |
| Analytical separation of tea catechins and food-related polyphenols by high-speed counter-current chromatography. | Journal of chromatography. A 20060421 |
| Potent inhibitory effects of black tea theaflavins on off-odor formation from citral. | Journal of agricultural and food chemistry 20060419 |
| Inhibition of CWR22Rnu1 tumor growth and PSA secretion in athymic nude mice by green and black teas. | Carcinogenesis 20060401 |
| Theaflavin-3, 3'-digallate induces epidermal growth factor receptor downregulation. | Molecular carcinogenesis 20060301 |
| Inhibitory effects of black tea theaflavin derivatives on 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and arachidonic acid metabolism in mouse ears. | Molecular nutrition & food research 20060201 |
| Antimicrobial activities of tea catechins and theaflavins and tea extracts against Bacillus cereus. | Journal of food protection 20060201 |
| Black tea polyphenols restrict benzopyrene-induced mouse lung cancer progression through inhibition of Cox-2 and induction of caspase-3 expression. | Asian Pacific journal of cancer prevention : APJCP 20060101 |
| Theaflavin ameliorates cerebral ischemia-reperfusion injury in rats through its anti-inflammatory effect and modulation of STAT-1. | Mediators of inflammation 20060101 |
| Induction of apoptosis in human leukemia cells by black tea and its polyphenol theaflavin. | Cancer letters 20051208 |
| Creaming in black tea. | Journal of agricultural and food chemistry 20051005 |
| Stability of black tea polyphenol, theaflavin, and identification of theanaphthoquinone as its major radical reaction product. | Journal of agricultural and food chemistry 20050727 |
| [Effect of tea polyphenols on oxidative metabolism of polymorphonuclear neutrophils in healthy and obese people]. | Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20050701 |
| Molecular definition of black tea taste by means of quantitative studies, taste reconstitution, and omission experiments. | Journal of agricultural and food chemistry 20050629 |
| Antioxidative properties of black tea. | Preventive medicine 20050601 |
| Black tea polyphenols suppress cell proliferation and induce apoptosis during benzo(a)pyrene-induced lung carcinogenesis. | European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 20050601 |
| Theaflavin derivatives in black tea and catechin derivatives in green tea inhibit HIV-1 entry by targeting gp41. | Biochimica et biophysica acta 20050525 |
| The theaflavin fraction is responsible for the facilitatory effect of black tea at the skeletal myoneural junction. | Life sciences 20050513 |
| Black tea theaflavins suppress dioxin-induced transformation of the aryl hydrocarbon receptor. | Bioscience, biotechnology, and biochemistry 20050501 |
| Inhibition of benzo[a]pyrene induced mutagenicity and genotoxicity by black tea polyphenols theaflavins and thearubigins in multiple test systems. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20050401 |
| [Study on the effect of theaflavins on the adhesion between monocyte and endothelial cells]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20050401 |
| The signal transduction networks required for phosphorylation of STAT1 at Ser727 in mouse epidermal JB6 cells in the UVB response and inhibitory mechanisms of tea polyphenols. | Carcinogenesis 20050201 |
| Optimization of theaflavin biosynthesis from tea polyphenols using an immobilized enzyme system and response surface methodology. | Biotechnology letters 20050201 |
| Correlation of apoptosis with comet formation induced by tea polyphenols in human leukemia cells. | Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20050101 |
| Amelioration of sodium arsenite-induced clastogenicity by tea extracts in Chinese hamster v79 cells. | Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20050101 |
| Black tea extract can modulate protein expression of H-ras, c-Myc, p53, and Bcl-2 genes during pulmonary hyperplasia, dysplasia, and carcinoma in situ. | Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20050101 |
| Ellipsometry analysis of the in vitro adsorption of tea polyphenols onto salivary pellicles. | European journal of oral sciences 20041201 |
| Antimicrobial activity of 10 different plant polyphenols against bacteria causing food-borne disease. | Biological & pharmaceutical bulletin 20041201 |
| [Preparation and component analysis of tea pigments]. | Wei sheng yan jiu = Journal of hygiene research 20041101 |
| Theaflavin, a black tea extract, is a novel anti-inflammatory compound. | Critical care medicine 20041001 |
| [Studies on antioxidant constituents from black tea]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20041001 |
| Black tea polyphenol theaflavins inhibit aromatase activity and attenuate tamoxifen resistance in HER2/neu-transfected human breast cancer cells through tyrosine kinase suppression. | European journal of cancer (Oxford, England : 1990) 20040901 |
| The theaflavin monomers inhibit the cancer cells growth in vitro. | Acta biochimica et biophysica Sinica 20040701 |
| Identification of the astringent taste compounds in black tea infusions by combining instrumental analysis and human bioresponse. | Journal of agricultural and food chemistry 20040602 |
| New dibenzotropolone derivatives characterized from black tea using LC/MS/MS. | Bioorganic & medicinal chemistry 20040601 |
| HPLC-MSn analysis of phenolic compounds and purine alkaloids in green and black tea. | Journal of agricultural and food chemistry 20040519 |
| Analysis of theaflavins and thearubigins from black tea extract by MALDI-TOF mass spectrometry. | Journal of agricultural and food chemistry 20040505 |
| Tea polyphenols inhibit acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acetyltransferase (a key enzyme in platelet-activating factor biosynthesis) and platelet-activating factor-induced platelet aggregation. | International archives of allergy and immunology 20040501 |
| Reaction of iron(III) with theaflavin: complexation and oxidative products. | Journal of inorganic biochemistry 20040401 |
| Comparative study of the growth-inhibitory and apoptosis-inducing activities of black tea theaflavins and green tea catechin on murine myeloid leukemia cells. | International journal of molecular medicine 20040301 |
| [Determination of theaflavins in black tea by high performance liquid chromatography]. | Se pu = Chinese journal of chromatography 20040301 |
| Modulation of phosphatidylinositol-3-kinase/protein kinase B- and mitogen-activated protein kinase-pathways by tea polyphenols in human prostate cancer cells. | Journal of cellular biochemistry 20040201 |
| Enzymatic synthesis of tea theaflavin derivatives and their anti-inflammatory and cytotoxic activities. | Bioorganic & medicinal chemistry 20040115 |
| Delivery of tea polyphenols to the oral cavity by green tea leaves and black tea extract. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20040101 |
| Cocoa has more phenolic phytochemicals and a higher antioxidant capacity than teas and red wine. | Journal of agricultural and food chemistry 20031203 |
| Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic Bcl-2-family proteins. | Cancer research 20031201 |
| Fermentation characteristics of some assamica clones and process optimization of black tea manufacturing. | Journal of agricultural and food chemistry 20031022 |
| Hepatic and intestinal cytochrome P450 and conjugase activities in rats treated with black tea theafulvins and theaflavins. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20030801 |
| Cholesterol-lowering effect of a theaflavin-enriched green tea extract: a randomized controlled trial. | Archives of internal medicine 20030623 |
| Carbon-13 CP-MAS nuclear magnetic resonance studies of teas. | Solid state nuclear magnetic resonance 20030501 |
| Evaluation of the anti-oxidative effect (in vitro) of tea polyphenols. | Bioscience, biotechnology, and biochemistry 20030201 |
| Signal transduction pathways: targets for green and black tea polyphenols. | Journal of biochemistry and molecular biology 20030131 |
| Regulation of hazardous exposure by protective exposure: modulation of phase II detoxification and lipid peroxidation by Camellia sinensis and Swertia chirata. | Teratogenesis, carcinogenesis, and mutagenesis 20030101 |
| Suppression of fatty acid synthase in MCF-7 breast cancer cells by tea and tea polyphenols: a possible mechanism for their hypolipidemic effects. | The pharmacogenomics journal 20030101 |
| Modulation of arsenic induced cytotoxicity by tea. | Asian Pacific journal of cancer prevention : APJCP 20030101 |
| Studies with black tea and its constituents on leukemic cells and cell lines. | Journal of experimental & clinical cancer research : CR 20021201 |
| Tea enhances insulin activity. | Journal of agricultural and food chemistry 20021120 |
| Antimutagenic effects of black tea (World Blend) and its two active polyphenols theaflavins and thearubigins in Salmonella assays. | Phytotherapy research : PTR 20021101 |
| Cancer chemoprevention by tea polyphenols through modulating signal transduction pathways. | Archives of pharmacal research 20021001 |
| Black tea represents a major source of dietary phenolics among regular tea drinkers. | Free radical research 20021001 |
| Comparative antimutagenic and anticlastogenic effects of green tea and black tea: a review. | Mutation research 20020901 |
| Mechanisms of chronic disease causation by nutritional factors and tobacco products and their prevention by tea polyphenols. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20020801 |
| Synthesis of theaflavin from epicatechin and epigallocatechin by plant homogenates and role of epicatechin quinone in the synthesis and degradation of theaflavin. | Journal of agricultural and food chemistry 20020327 |
| Evaluation of the antigenotoxic potential of monomeric and dimeric flavanols, and black tea polyphenols against heterocyclic amine-induced DNA damage in human lymphocytes using the Comet assay. | Mutation research 20020325 |
| Black tea polyphenols, theaflavins, prevent cellular DNA damage by inhibiting oxidative stress and suppressing cytochrome P450 1A1 in cell cultures. | Journal of agricultural and food chemistry 20020102 |
| Anti-invasive effects of green tea polyphenol epigallocatechin-3-gallate (EGCG), a natural inhibitor of metallo and serine proteases. | Biological chemistry 20020101 |
| Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced inflammatory skin edema and ornithine decarboxylase activity by theaflavin-3,3'-digallate in mouse. | Nutrition and cancer 20020101 |
| [Protective effect of tea pigments on mice skin photoaging induced by UV irradiation]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20020101 |
| Improvement of tea leaves fermentation with Aspergillus spp. pectinase. | Journal of bioscience and bioengineering 20020101 |
| Two types of oxidative dimerization of the black tea polyphenol theaflavin. | Journal of agricultural and food chemistry 20011201 |
| Effects of purified green and black tea polyphenols on cyclooxygenase- and lipoxygenase-dependent metabolism of arachidonic acid in human colon mucosa and colon tumor tissues. | Biochemical pharmacology 20011101 |
| Anticlastogenic effects of black tea (World blend) and its two active polyphenols theaflavins and thearubigins in vivo in Swiss albino mice. | Life sciences 20011026 |
| Analysis of theaflavins in biological fluids using liquid chromatography-electrospray mass spectrometry. | Journal of chromatography. B, Biomedical sciences and applications 20010905 |
| Black tea is a powerful chemopreventor of reactive oxygen and nitrogen species: comparison with its individual catechin constituents and green tea. | Biochemical and biophysical research communications 20010601 |
| Analysis of black tea theaflavins by non-aqueous capillary electrophoresis. | Journal of chromatography. A 20010601 |
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