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4291-63-8 | Cladribine
CAS No: 4291-63-8 Catalog No: AG003P0J MDL No:MFCD00153939
Product Description
Catalog Number:
AG003P0J
Chemical Name:
Cladribine
CAS Number:
4291-63-8
Molecular Formula:
C10H12ClN5O3
Molecular Weight:
285.6870
MDL Number:
MFCD00153939
IUPAC Name:
(2R,3S,5R)-5-(6-amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol
InChI:
InChI=1S/C10H12ClN5O3/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,6+/m0/s1
InChI Key:
PTOAARAWEBMLNO-KVQBGUIXSA-N
SMILES:
OCC1OC(CC1O)n1cnc2c1nc(Cl)nc2N
UNII:
47M74X9YT5
Properties
Complexity:
338
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
3
Defined Bond Stereocenter Count:
0
Exact Mass:
285.063g/mol
Formal Charge:
0
Heavy Atom Count:
19
Hydrogen Bond Acceptor Count:
7
Hydrogen Bond Donor Count:
3
Isotope Atom Count:
0
Molecular Weight:
285.688g/mol
Monoisotopic Mass:
285.063g/mol
Rotatable Bond Count:
2
Topological Polar Surface Area:
119A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
0.8
Literature
| Title | Journal |
|---|---|
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| ABT-737 resistance in B-cells isolated from chronic lymphocytic leukemia patients and leukemia cell lines is overcome by the pleiotropic kinase inhibitor quercetin through Mcl-1 down-regulation. | Biochemical pharmacology 20130401 |
| Topotecan exposure estimation in pediatric acute myeloid leukemia supported by LC-MS-based drug monitoring and pharmacokinetic analysis. | Journal of pharmaceutical and biomedical analysis 20121101 |
| Cladribine is effective against cystic pulmonary Langerhans cell histiocytosis. | American journal of respiratory and critical care medicine 20121101 |
| Fludarabine and cladribine induce changes in surface proteins on human B-lymphoid cell lines involved with apoptosis, cell survival, and antitumor immunity. | Journal of proteome research 20120907 |
| Can ex vivo evaluation (testing) predict the sensitivity of CLL cells to therapy with purine analogs in conjunction with an alkylating agent? A comparison of in vivo and ex vivo responses to treatment. | Medical oncology (Northwood, London, England) 20120901 |
| Changes in the apoptotic gene expression profile in CLL patients treated with rituximab combined with cladribine and cyclophosphamide-preliminary results. | Leukemia research 20120901 |
| Cladribine, but not fludarabine, added to daunorubicin and cytarabine during induction prolongs survival of patients with acute myeloid leukemia: a multicenter, randomized phase III study. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120710 |
| Phosphorylation of deoxycytidine kinase on Ser-74: impact on kinetic properties and nucleoside analog activation in cancer cells. | Biochemical pharmacology 20120701 |
| Poor prognosis of Hodgkin variant of Richter transformation in chronic lymphocytic leukemia treated with cladribine. | British journal of haematology 20120701 |
| Haematological cancer: The rule of three in AML induction--is cladribine the answer? | Nature reviews. Clinical oncology 20120619 |
| Langerhans cell histiocytosis with central nervous system involvement--complete response to 2-chlorodeoxyadenosine after failure of tyrosine kinase inhibitor therapies with sorafenib and imatinib. | Hematological oncology 20120601 |
| Haematopoietic SCT in severe autoimmune diseases: updated guidelines of the European Group for Blood and Marrow Transplantation. | Bone marrow transplantation 20120601 |
| High incidence of skin rash in patients with hairy cell leukemia treated with cladribine. | Leukemia & lymphoma 20120601 |
| Novel and emerging drugs for acute myeloid leukemia. | Current cancer drug targets 20120601 |
| Langerhans's cell histiocytosis in old subjects: two rare case reports and review of the literature. | Gerodontology 20120601 |
| [Cladribine is highly effective in the treatment of Langerhans cell histiocytosis and rare histiocytic disorders of the juvenile xanthogranuloma group]. | Vnitrni lekarstvi 20120601 |
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| ABC transporters and their role in nucleoside and nucleotide drug resistance. | Biochemical pharmacology 20120415 |
| Drugs: An injection of hope. | Nature 20120412 |
| Secondary T-lymphoblastic leukemia in a patient with hairy cell leukemia following cladribine therapy: report of an extremely rare case and review of the literature. | Leukemia & lymphoma 20120401 |
| AMD3100 disrupts the cross-talk between chronic lymphocytic leukemia cells and a mesenchymal stromal or nurse-like cell-based microenvironment: pre-clinical evidence for its association with chronic lymphocytic leukemia treatments. | Haematologica 20120401 |
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| Second line chemotherapy in patients with enteropathy-associated T cell lymphoma: a retrospective single center analysis. | Annals of hematology 20120101 |
| Cladribine as a therapeutic option in multiple sclerosis. | Clinical immunology (Orlando, Fla.) 20120101 |
| Reduction in healthcare and societal resource utilization associated with cladribine tablets in patients with relapsing-remitting multiple sclerosis: analysis of economic data from the CLARITY Study. | Clinical drug investigation 20120101 |
| Severe life-threatening or disabling anaphylaxis in patients with systemic mastocytosis: a single-center experience. | International archives of allergy and immunology 20120101 |
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| Successful Long Term Eradication of Factor VIII Inhibitor in Patients with Acquired Haemophilia A in Saudi Arabia. | Mediterranean journal of hematology and infectious diseases 20120101 |
| Recombinant T-Cell Receptor Ligand (RTL) for Treatment of Multiple Sclerosis: A Double-Blind, Placebo-Controlled, Phase 1, Dose-Escalation Study. | Autoimmune diseases 20120101 |
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| Novel quinazolinone MJ-29 triggers endoplasmic reticulum stress and intrinsic apoptosis in murine leukemia WEHI-3 cells and inhibits leukemic mice. | PloS one 20120101 |
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| Two Cases of Cerebral Involvement in Malignant Lymphoma (CD20+) That Responded to Combination Therapy with Rituximab and Cladribine. | Case reports in oncology 20120101 |
| [Treatment of Langerhans cells histiocytosis by cladribin reached long-term complete remission in 9 out of 10 adult patients]. | Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti 20120101 |
| Preclinical antitumor activity of thiarabine in human leukemia and lymphoma xenograft models. | Nucleosides, nucleotides & nucleic acids 20120101 |
| [Treatment for recurrent hairy cell leukemia]. | Terapevticheskii arkhiv 20120101 |
| Chronic cladribine administration increases amyloid beta peptide generation and plaque burden in mice. | PloS one 20120101 |
| Cladribine inhibits cytokine secretion by T cells independently of deoxycytidine kinase activity. | Journal of neuroimmunology 20111215 |
| Interferon-alpha is a very effective salvage therapy for patients with hairy cell leukemia relapsing after cladribine: a report of three cases. | Medical oncology (Northwood, London, England) 20111201 |
| Irreversible marrow aplasia after single course of 2-chlorodeoxyadenosine for hairy cell leukaemia preceding by A pandemic 2009-H1N1-associated pneumonia. | Medical oncology (Northwood, London, England) 20111201 |
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| Seventy-nine-year-old man with Langerhans cell histiocytosis treated with cladribine. | Journal of the American Academy of Dermatology 20110901 |
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| Synthesis and significant cytostatic activity of 7-hetaryl-7-deazaadenosines. | Journal of medicinal chemistry 20110811 |
| Effective treatment of leukemia cutis with combination of rituximab, cladribine, and cyclophosphamide in patient with B-cell chronic lymphocytic leukemia. | Annals of hematology 20110801 |
| Cladribine plus rituximab is an effective therapy for newly diagnosed mantle cell lymphoma. | Leukemia & lymphoma 20110801 |
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| Multiple sclerosis: Cladribine--a contentious therapeutic contender for MS. | Nature reviews. Neurology 20110712 |
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| The therapeutic effect of a pulsed electromagnetic field on the reproductive patterns of male Wistar rats exposed to a 2.45-GHz microwave field. | Clinics (Sao Paulo, Brazil) 20110701 |
| Auto-SCT in refractory celiac disease type II patients unresponsive to cladribine therapy. | Bone marrow transplantation 20110601 |
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| Mechanism of action of pentostatin and cladribine in hairy cell leukemia. | Leukemia & lymphoma 20110601 |
| Implications of minimal residual disease in hairy cell leukemia after cladribine using immunohistochemistry and immunophenotyping. | Leukemia & lymphoma 20110601 |
| Purine analog toxicity in patients with hairy cell leukemia. | Leukemia & lymphoma 20110601 |
| Alternative methods of cladribine administration. | Leukemia & lymphoma 20110601 |
| Rituximab with pentostatin or cladribine: an effective combination treatment for hairy cell leukemia after disease recurrence. | Leukemia & lymphoma 20110601 |
| Insight into the behavior of hairy cell leukemia by immunogenetic analysis. | Leukemia & lymphoma 20110601 |
| Development of cladribine at Scripps for hairy cell leukemia and current results. | Leukemia & lymphoma 20110601 |
| Fifty years of hairy cell leukemia treatments. | Leukemia & lymphoma 20110601 |
| Long-term results for pentostatin and cladribine treatment of hairy cell leukemia. | Leukemia & lymphoma 20110601 |
| Hairy cell leukemia: a successful model for experimental therapeutics--pentostatin and new ideas. | Leukemia & lymphoma 20110601 |
| Hairy cell leukemia: epidemiology, pharmacokinetics of cladribine, and long-term follow-up of subcutaneous therapy. | Leukemia & lymphoma 20110601 |
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| American academy of neurology annual meeting. | International MS journal 20110501 |
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| Resveratrol increases rate of apoptosis caused by purine analogues in malignant lymphocytes of chronic lymphocytic leukemia. | Annals of hematology 20110201 |
| Cladribine combined with rituximab (R-2-CdA) therapy is an effective salvage therapy in relapsed or refractory indolent B-cell non-Hodgkin lymphoma. | European journal of haematology 20110201 |
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| Impact of cladribine on soluble adhesion molecules in multiple sclerosis. | Acta neurologica Scandinavica 20101201 |
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| Prognostic impact of combined fludarabine, treosulfan and mitoxantrone resistance profile in childhood acute myeloid leukemia. | Anticancer research 20080101 |
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| Disease-modifying agents for multiple sclerosis: recent advances and future prospects. | Drugs 20080101 |
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| Complete molecular remission induced by concomitant cladribine--rituximab treatment in a case of multi-resistant hairy cell leukemia. | Leukemia & lymphoma 20071201 |
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| Therapeutic experience of Bing-Neel Syndrome associated with Waldenstrom's macroglobulinemia. | Journal of Korean medical science 20071201 |
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| Role of nelarabine in the treatment of T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma. | Therapeutics and clinical risk management 20071201 |
| The role of rituximab in combination with pentostatin or cladribine for the treatment of recurrent/refractory hairy cell leukemia. | Cancer 20071115 |
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| Primary chronic cold agglutinin disease: an update on pathogenesis, clinical features and therapy. | Hematology (Amsterdam, Netherlands) 20071001 |
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| Rituximab plus cladribine with or without cyclophosphamide in patients with relapsed or refractory chronic lymphocytic leukemia. | European journal of haematology 20070801 |
| t(14;18)(q32;q21)-bearing pleural MALT lymphoma with IgM paraproteinemia: value of detection of specific cytogenetic abnormalities in the differential diagnosis of MALT lymphoma and lymphoplasmacytic lymphoma. | Hematology (Amsterdam, Netherlands) 20070801 |
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| Comparison of fast liquid chromatography/tandem mass spectrometric methods for simultaneous determination of cladribine and clofarabine in mouse plasma. | Journal of pharmaceutical and biomedical analysis 20070628 |
| Cell cycle effect on the activity of deoxynucleoside analogue metabolising enzymes. | Biochemical and biophysical research communications 20070615 |
| Hairy cell leukaemia complicated by anti-MAG paraproteinemic demyelinating neuropathy: resolution of neurological syndrome after cladribrine treatment. | Leukemia research 20070601 |
| Compared benefit of approved and experimental immunosuppressive therapeutic approaches in multiple sclerosis. | Expert opinion on pharmacotherapy 20070601 |
| Cladribine in aggressive forms of multiple sclerosis. | European journal of neurology 20070601 |
| Cladribine combined with cyclophosphamide and mitoxantrone is an active salvage therapy in advanced non-Hodgkin's lymphoma. | Leukemia & lymphoma 20070601 |
| Imatinib and tyrosine kinase inhibition, in the management of BCR-ABL negative myeloproliferative disorders. | Biologics : targets & therapy 20070601 |
| Cladribine in a weekly versus daily schedule for untreated active hairy cell leukemia: final report from the Polish Adult Leukemia Group (PALG) of a prospective, randomized, multicenter trial. | Blood 20070501 |
| Drug resistance in B-cell chronic lymphocytic leukemia: predictable by in vitro evaluation with a multiparameter flow cytometric cytotoxicity assay. | Cytometry. Part B, Clinical cytometry 20070501 |
| Influence of cladribine alone and in combination with cyclophosphamide or cyclophosphamide and mitoxantrone on bone marrow angiogenesis in chronic lymphocytic leukemia. | Leukemia & lymphoma 20070501 |
| Systemic mastocytosis: a concise clinical and laboratory review. | Archives of pathology & laboratory medicine 20070501 |
| Novel oral agents for multiple sclerosis. | Current neurology and neuroscience reports 20070501 |
| Dihydrodiol dehydrogenase in drug resistance and sensitivity of human carcinomas. | Cancer chemotherapy and pharmacology 20070401 |
| Current treatment options in prolymphocytic leukemia. | Medical science monitor : international medical journal of experimental and clinical research 20070401 |
| Hairy Cell Leukemia. | Current treatment options in oncology 20070401 |
| Presence of the anti-leukemic nucleotide analog, 2-chloro-2'-deoxyadenosine-5'-monophosphate, in a promoter sequence alters DNA binding of TATA-binding protein (TBP). | Archives of biochemistry and biophysics 20070315 |
| Two novel nucleoside ester derivatives of chlorambucil as potential antileukemic prodrugs: a preliminary study. | Anti-cancer drugs 20070301 |
| Complete response in a patient with colonic mantle cell lymphoma with multiple lymphomatous polyposis treated with combination chemotherapy using anti-CD20 antibody and cladribine. | Gut 20070301 |
| Update on the management of refractory coeliac disease. | Journal of gastrointestinal and liver diseases : JGLD 20070301 |
| Membrane localization and pH-dependent transport of a newly cloned organic cation transporter (PMAT) in kidney cells. | American journal of physiology. Renal physiology 20070201 |
| Pharmacological inhibition of the MAPK/ERK pathway increases sensitivity to 2-chloro-2'-deoxyadenosine (CdA) in the B-cell leukemia cell line EHEB. | Biochemical pharmacology 20070201 |
| Fludarabine vs cladribine plus busulfan and low-dose TBI as reduced intensity conditioning for allogeneic hematopoietic stem cell transplantation: a prospective randomized trial. | Bone marrow transplantation 20070201 |
| Effect of frequently used chemotherapeutic drugs on the cytotoxic activity of human natural killer cells. | Molecular cancer therapeutics 20070201 |
| The multicenter trial SAKK 37/95 of cladribine, cyclophosphamide and prednisone in the treatment of chronic lymphocytic leukemias and low-grade non-Hodgkin's lymphomas. | Acta haematologica 20070101 |
| Langerhans cell histiocytosis of vulva in adolescent. | International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20070101 |
| A novel small molecule that selectively inhibits glioblastoma cells expressing EGFRvIII. | Molecular cancer 20070101 |
| Development of hairy cell leukemia in a patient with antiphospholipid syndrome. | Lupus 20070101 |
| Oral disease-modifying treatments for multiple sclerosis: the story so far. | CNS drugs 20070101 |
| [Treatment of hairy cell leukemia with cladribine]. | Lijecnicki vjesnik 20070101 |
| I have good news! You have leukemia. | Clinics in dermatology 20070101 |
| Development and validation of a sensitive and specific HPLC assay of cladribine for pharmacokinetics studies in rats. | Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20070101 |
| The management of complicated celiac disease. | Digestive diseases (Basel, Switzerland) 20070101 |
| Development and validation of an assay for the quantitative determination of cladribine nucleotides in MDCKII cells and culture medium using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry. | Rapid communications in mass spectrometry : RCM 20070101 |
| Hypereosinophilic syndrome, chronic eosinophilic leukemia, and mast cell disease. | Cancer journal (Sudbury, Mass.) 20070101 |
| The effects of nucleoside analogues on promoter methylation of selected tumor suppressor genes in MCF-7 and MDA-MB-231 breast cancer cell lines. | Nucleosides, nucleotides & nucleic acids 20070101 |
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| Activity and toxicity of 2-CDA in Langerhans cell histiocytosis: a single institutional experience. | Indian journal of cancer 20070101 |
| Neglected respiratory toxicity caused by cancer therapy. | The open respiratory medicine journal 20070101 |
| Prolonged follow-up after initial therapy with 2-chlorodeoxyadenosine in patients with indolent non-Hodgkin lymphoma: results of Cancer and Leukemia Group B Study 9153. | Cancer 20061215 |
| Lipid raft disruption prevents apoptosis induced by 2-chloro-2'-deoxyadenosine (Cladribine) in leukemia cell lines. | Leukemia research 20061201 |
| In vitro sensitivity of B-cell chronic lymphocytic leukemia to cladribine and its combinations with mafosfamide and/or mitoxantrone. | Oncology reports 20061201 |
| Cytotoxic effect of R-etodolac (SDX-101) in combination with purine analogs or monoclonal antibodies on ex vivo B-cell chronic lymphocytic leukemia cells. | Leukemia & lymphoma 20061201 |
| Dramatic clinical efficacy of cladribine in Rosai-Dorfman disease and evolution of the cytokine profile: towards a new therapeutic approach. | Haematologica 20061201 |
| [Mastocytosis--mastcell proliferative disease risk of anaphylactic reaction]. | Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20061201 |
| Efficacy of low dose clofarabine in refractory precursor T- acute lymphoblastic leukemia. | The Yale journal of biology and medicine 20061201 |
| Prolonged clinical remission in patients with extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue type treated with cladribine: 6 year follow-up of a phase II trial. | Annals of oncology : official journal of the European Society for Medical Oncology 20061101 |
| Cladribine therapy in refractory celiac disease with aberrant T cells. | Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20061101 |
| 2-CdA in the treatment of hairy cell leukemia: a review of long-term follow-up. | Leukemia & lymphoma 20061101 |
| Treatment of clonal refractory celiac disease or cryptic intraepithelial lymphoma: A long road from bench to bedside. | Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20061101 |
| Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) treated with 2-chlorodeoxyadenosine. | Pediatric blood & cancer 20061015 |
| Novel approaches in the treatment of systemic mastocytosis. | Cancer 20061001 |
| Rituximab combined with cladribine or with cladribine and cyclophosphamide in heavily pretreated patients with indolent lymphoproliferative disorders and mantle cell lymphoma. | Cancer 20061001 |
| Cladribine: an investigational immunomodulatory agent for multiple sclerosis. | The Annals of pharmacotherapy 20061001 |
| Pentostatin: impact on outcome in hairy cell leukemia. | Hematology/oncology clinics of North America 20061001 |
| Cladribine in hairy cell leukemia. | Hematology/oncology clinics of North America 20061001 |
| [Successful salvage therapy with cladribine and rituximab for a patient with a relapsed Asian variant of intravascular large B-cell lymphoma]. | [Rinsho ketsueki] The Japanese journal of clinical hematology 20061001 |
| New directions in the treatment of mantle cell lymphoma: an overview. | Clinical lymphoma & myeloma 20061001 |
| Regiospecific and highly stereoselective coupling of 6-(substituted-imidazol-1-yl)purines with 2-deoxy-3,5-di-O-(p-toluoyl)-alpha-D-erythro-pentofuranosyl chloride. Sodium-salt glycosylation in binary solvent mixtures: improved synthesis of cladribine. | The Journal of organic chemistry 20060929 |
| Molecular determinants of specificity for synthetic nucleoside analogs in the concentrative nucleoside transporter, CNT2. | The Journal of biological chemistry 20060908 |
| Hairy cell leukemia. | Current oncology reports 20060901 |
| Treatment of recurrent Langerhans cell histiocytosis in children with 2-chlorodeoxyadenosine. | Leukemia & lymphoma 20060901 |
| Severe neuropathy in a patient with Waldenstrom disease: from a challenging diagnosis to clinical improvement by innovative therapy. | Leukemia & lymphoma 20060901 |
| Asparaginase (native ASNase or pegylated ASNase) in the treatment of acute lymphoblastic leukemia. | International journal of nanomedicine 20060901 |
| In vitro synergistic cytotoxicity of gemcitabine and pemetrexed and pharmacogenetic evaluation of response to gemcitabine in bladder cancer patients. | British journal of cancer 20060807 |
| Current treatment options in hairy cell leukemia and hairy cell leukemia variant. | Cancer treatment reviews 20060801 |
| Single-agent purine analogues for the treatment of chronic lymphocytic leukaemia: a systematic review and meta-analysis. | Cancer treatment reviews 20060801 |
| Role of interferon-alpha administration after 2-deoxycoformycin in the treatment of hairy cell leukemia patients. | European journal of haematology 20060801 |
| KIT mutations in mastocytosis and their potential as therapeutic targets. | Immunology and allergy clinics of North America 20060801 |
| High activity of rituximab combined with cladribine and cyclophosphamide in a patient with pulmonary lymphomatoid granulomatosis and bone marrow involvement. | Leukemia & lymphoma 20060801 |
| Hairy-cell leukaemia: first-line treatment with cladribine or pentostatin. | Prescrire international 20060801 |
| Multiply relapsing hairy cell leukemia responsive to repeated courses of rituximab: a case report. | Hematology (Amsterdam, Netherlands) 20060801 |
| Purine antagonists for chronic lymphocytic leukaemia. | The Cochrane database of systematic reviews 20060719 |
| Cladribine alone and in combination with cyclophosphamide or cyclophosphamide plus mitoxantrone in the treatment of progressive chronic lymphocytic leukemia: report of a prospective, multicenter, randomized trial of the Polish Adult Leukemia Group (PALG CLL2). | Blood 20060715 |
| Enforced expression of cytosolic 5'-nucleotidase I confers resistance to nucleoside analogues in vitro but systemic chemotherapy toxicity precludes in vivo selection. | Cancer chemotherapy and pharmacology 20060701 |
| Clinical and pharmacokinetic study of clofarabine in chronic lymphocytic leukemia: strategy for treatment. | Clinical cancer research : an official journal of the American Association for Cancer Research 20060701 |
| [Pulmonary cryptococcosis occurring 6 months after cladribine therapy for relapsed follicular lymphoma]. | [Rinsho ketsueki] The Japanese journal of clinical hematology 20060701 |
| AMN107 (nilotinib): a novel and selective inhibitor of BCR-ABL. | British journal of cancer 20060619 |
| Eradication of minimal residual disease in hairy cell leukemia. | Blood 20060615 |
| [Hypersensitivity reactions to multiple drugs during the course of hairy cell leukemia treated with 2-chlorodeoxyadenosine]. | Arerugi = [Allergy] 20060601 |
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| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| New agents in chronic lymphocytic leukemia. | Current treatment options in oncology 20060501 |
| Cryptococcus neoformans meningitis in a patient with hairy cell leukemia. | American journal of hematology 20060501 |
| The role of purine analogues in low-intensity regimens with allogeneic hematopoietic stem cell transplantation. | Seminars in hematology 20060401 |
| Update on extranodal lymphomas. Conclusions of the Workshop held by the EAHP and the SH in Thessaloniki, Greece. | Histopathology 20060401 |
| [Histiocytosis from Langerhans cell in adults--experience of one department and review of treatment alternatives]. | Vnitrni lekarstvi 20060401 |
| The pattern of deoxycytidine- and deoxyguanosine kinase activity in relation to messenger RNA expression in blood cells from untreated patients with B-cell chronic lymphocytic leukemia. | Biochemical pharmacology 20060314 |
| Accumulation of irreversible disability in multiple sclerosis: from epidemiology to treatment. | Clinical neurology and neurosurgery 20060301 |
| Guidelines on the management of Waldenström macroglobulinaemia. | British journal of haematology 20060301 |
| Potential predictive patterns of minimal residual disease detected by immunohistochemistry on bone marrow biopsy specimens during a long-term follow-up in patients treated with cladribine for hairy cell leukemia. | Archives of pathology & laboratory medicine 20060301 |
| Advances in the treatment of chronic lymphocytic leukemia. | Current hematologic malignancy reports 20060301 |
| Effects of drug combinations on smooth muscle cell proliferation: an isobolographic analysis. | European journal of pharmacology 20060217 |
| Development of hairy cell leukemia in a patient after cardiac transplantation. | Leukemia & lymphoma 20060201 |
| The structure of human deoxycytidine kinase in complex with clofarabine reveals key interactions for prodrug activation. | Acta crystallographica. Section D, Biological crystallography 20060201 |
| Transformation and progression of Waldenström's macroglobulinemia following cladribine therapy in two cases: natural evolution or iatrogenic causation? | American journal of hematology 20060201 |
| Future perspectives in the treatment of cutaneous T-cell lymphoma (CTCL). | Seminars in oncology 20060201 |
| CASE 1. Langerhans cell histiocytosis of the thyroid. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060120 |
| PKC412 inhibits in vitro growth of neoplastic human mast cells expressing the D816V-mutated variant of KIT: comparison with AMN107, imatinib, and cladribine (2CdA) and evaluation of cooperative drug effects. | Blood 20060115 |
| A comparison of the transportability, and its role in cytotoxicity, of clofarabine, cladribine, and fludarabine by recombinant human nucleoside transporters produced in three model expression systems. | Molecular pharmacology 20060101 |
| Concomitant hairy cell and acute myeloid leukemia. | European journal of haematology 20060101 |
| PRIMA-1 induces apoptosis in acute myeloid leukaemia cells with p53 gene deletion. | British journal of haematology 20060101 |
| Early-onset autoimmune hemolytic anemia after cladribine therapy for Waldenström's macroglobulinemia. | Transfusion 20060101 |
| Hairy cell leukemia: a diagnosis by endoscopic ultrasound guided fine needle aspiration. | CytoJournal 20060101 |
| In vitro sensitivity and cross-resistance to deoxynucleoside analogs in childhood acute leukemia. | Haematologica 20060101 |
| The relation between deoxycytidine kinase activity and the radiosensitising effect of gemcitabine in eight different human tumour cell lines. | BMC cancer 20060101 |
| Efficacy and tolerability of gemtuzumab ozogamicin (anti-CD33 monoclonal antibody, CMA-676, Mylotarg) in children with relapsed/refractory myeloid leukemia. | BMC cancer 20060101 |
| Hairy cell leukemia: an elusive but treatable disease. | The oncologist 20060101 |
| Multiple opportunistic infections after high-dose steroid therapy for giant cell arteritis in a patient previously treated with a purine analog. | Scandinavian journal of infectious diseases 20060101 |
| Cellular resistance against troxacitabine in human cell lines and pediatric patient acute myeloid leukemia blast cells. | Nucleosides, nucleotides & nucleic acids 20060101 |
| Study of the efficacy of a pronucleotide of 2-chloro-2'-deoxyadenosine in deoxycytidine kinase-deficient lymphoma cells. | Nucleosides, nucleotides & nucleic acids 20060101 |
| Micro-array analysis of resistance for gemcitabine results in increased expression of ribonucleotide reductase subunits. | Nucleosides, nucleotides & nucleic acids 20060101 |
| Inhibition of the ERK pathway promotes apoptosis induced by 2-chloro-2'-deoxyadenosine in the B-cell leukemia cell line EHEB. | Nucleosides, nucleotides & nucleic acids 20060101 |
| Alteration of DNA methylation status in K562 and MCF-7 cancer cell lines by nucleoside analogues. | Nucleosides, nucleotides & nucleic acids 20060101 |
| Cytotoxic drug sensitivity of Epstein-Barr virus transformed lymphoblastoid B-cells. | BMC cancer 20060101 |
| Hairy-cell leukemia: a rare blood disorder in Asia. | The Southeast Asian journal of tropical medicine and public health 20060101 |
| Older and new formulations of cladribine. Pharmacology and clinical efficacy in hematological malignancies. | Recent patents on anti-cancer drug discovery 20060101 |
| Recent clinical trials of cladribine in hematological malignancies and autoimmune disorders. | Reviews on recent clinical trials 20060101 |
| The human equilibrative nucleoside transporter 1 mediates in vitro cytarabine sensitivity in childhood acute myeloid leukaemia. | British journal of cancer 20051212 |
| Long remissions in hairy cell leukemia with purine analogs: a report of 219 patients with a median follow-up of 12.5 years. | Cancer 20051201 |
| Clofarabine in the treatment of acute myeloid leukaemia and acute lymphoblastic leukaemia: a review. | Expert opinion on pharmacotherapy 20051201 |
| Addition of cladribine to induction/consolidation regimen does not impair peripheral blood stem cell mobilization and bone marrow harvest for autotransplantation in acute myeloid leukemia patients. | Transplantation proceedings 20051201 |
| Asymmetries in the spatial distributions of enhancing lesions and black holes in relapsing-remitting MS. | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20051101 |
| Drug therapy for the treatment of Langerhans cell histiocytosis. | Expert opinion on pharmacotherapy 20051101 |
| Complete remission of hairy cell leukemia variant (HCL-v) complicated by red cell aplasia post treatment with rituximab. | Haematologica 20051101 |
| Cladribine for multiple sclerosis: review and current status. | Expert review of neurotherapeutics 20051101 |
| Mast cell leukaemia. | British journal of haematology 20051101 |
| Multi-centre pilot study of 2-chlorodeoxyadenosine and cytosine arabinoside combined chemotherapy in refractory Langerhans cell histiocytosis with haematological dysfunction. | European journal of cancer (Oxford, England : 1990) 20051101 |
| [Successful treatment with cladribine for hypoplastic hairy cell leukemia after long-term neutropenia]. | [Rinsho ketsueki] The Japanese journal of clinical hematology 20051101 |
| [Successful rituximab treatment in a patient with refractory hairy cell leukemia-Japanese variant and suffering from acute respiratory distress]. | [Rinsho ketsueki] The Japanese journal of clinical hematology 20051101 |
| [Systemic mastocytosis]. | La Revue du praticien 20051015 |
| Severe, refractory type II essential mixed cryoglobulinemia treated with 2-chlorodeoxyadenosine and mycophenolate mofetil. | Rheumatology international 20051001 |
| Cladribine therapy in a patient with an aleukemic subvariant of mast cell leukemia. | Annals of hematology 20051001 |
| Old and new insights into the mechanisms of action of two nucleoside analogs active in lymphoid malignancies: fludarabine and cladribine (review). | International journal of oncology 20051001 |
| High activity and incomplete cross resistance of nucleoside analogues cladribine and fludarabine versus Ara-C on leukemic cells from patients with AML. | Therapeutic drug monitoring 20051001 |
| Comparison of cladribine plus prednisone with chlorambucil plus prednisone in patients with chronic lymphocytic leukemia. Final report of the Polish Adult Leukemia Group (PALG CLL1). | Medical science monitor : international medical journal of experimental and clinical research 20051001 |
| Potentiation of in vitro ara-C cytotoxicity by ribonucleotide reductase inhibitors, cyclin-dependent kinase modulators and the DNA repair inhibitor aphidicolin in paediatric acute myeloid leukaemia. | British journal of haematology 20051001 |
| Phase II clinical study of cladribine in the treatment of hairy cell leukemia. | International journal of hematology 20051001 |
| [Case of intraspinal epidural tumor developing after systemic mastocytosis with marked osteosclerosis and myelofibrosis]. | [Rinsho ketsueki] The Japanese journal of clinical hematology 20051001 |
| A multicenter, open, noncomparative, phase II study of the combination of cladribine (2-chlorodeoxyadenosine), cytarabine, granulocyte colony-stimulating factor and mitoxantrone as induction therapy in refractory acute myeloid leukemia: a report of the Polish Adult Leukemia Group. | Annals of hematology 20050901 |
| Quantitation of synergism of arabinosylcytosine and cladribine against the growth of arabinosylcytosine-resistant human lymphoid cells. | Journal of cancer research and clinical oncology 20050901 |
| Advances in the treatment of chronic lymphocytic leukemia. | Current oncology reports 20050901 |
| History of modern multiple sclerosis therapy. | Journal of neurology 20050901 |
| Identification of molecular mechanisms for cellular drug resistance by combining drug activity and gene expression profiles. | British journal of cancer 20050822 |
| Cytosine arabinoside affects multiple cellular factors and induces drug resistance in human lymphoid cells. | Biochemical pharmacology 20050801 |
| 2-Chlorodeoxyadenosine and cytarabine combination therapy for idiopathic hypereosinophilic syndrome. | Cancer 20050801 |
| Hairy cell leukemia (HCL) with extensive myelofibrosis responds to thalidomide. | Leukemia research 20050801 |
| Activity of cladribine combined with etoposide in heavily pretreated patients with indolent lymphoid malignancies. | Chemotherapy 20050801 |
| The natural product honokiol induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia (B-CLL) cells. | Blood 20050715 |
| Treatment of hairy cell leukemia with 2-chlorodeoxyadenosine (2-CdA): long-term follow-up of the Northwestern University experience. | Blood 20050701 |
| Docking simulation with a purine nucleoside specific homology model of deoxycytidine kinase, a target enzyme for anticancer and antiviral therapy. | Bioorganic & medicinal chemistry 20050701 |
| The effect of subsequent therapies in patients with chronic lymphocytic leukemia previously treated with prednisone and either cladribine or chlorambucil. | Haematologica 20050701 |
| Chemotherapeutic experience in indeterminate cell histiocytosis. | The British journal of dermatology 20050701 |
| Merkel cell carcinoma in a patient with B-cell chronic lymphocytic leukemia treated with cladribine and rituximab. | Leukemia & lymphoma 20050601 |
| The role of clofarabine in hematologic and solid malignancies--development of a next-generation nucleoside analog. | Cancer 20050515 |
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| In vitro cytotoxic effect of proteasome inhibitor bortezomib in combination with purine nucleoside analogues on chronic lymphocytic leukaemia cells. | European journal of haematology 20050501 |
| Hairy cell leukemia: clinical presentation and long term follow up after treatment with 2-chlorodeoxyadenosine (2-CdA). | JPMA. The Journal of the Pakistan Medical Association 20050501 |
| Successful treatment of extranodal Hodgkin's lymphoma in a patient with longstanding hairy cell leukemia. | Leukemia & lymphoma 20050501 |
| Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes. | The Journal of biological chemistry 20050422 |
| Activation of deoxycytidine kinase by deoxyadenosine: implications in deoxyadenosine-mediated cytotoxicity. | Archives of biochemistry and biophysics 20050401 |
| An analysis of the utilisation of chemoprophylaxis against Pneumocystis jirovecii pneumonia in patients with malignancy receiving corticosteroid therapy at a cancer hospital. | British journal of cancer 20050314 |
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| Langerhans cell histiocytosis with central nervous system involvement: follow-up by FDG-PET during treatment with cladribine. | Pediatric blood & cancer 20050301 |
| In vitro drug resistance in B cell chronic lymphocytic leukemia: a comparison with acute myelocytic and acute lymphocytic leukemia. | Anti-cancer drugs 20050301 |
| Diagnosis and management of Waldenstrom's macroglobulinemia. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050301 |
| [Metabolism, mechanism of action and resistance to cytotoxic nucleoside analogues]. | Bulletin du cancer 20050301 |
| The place of cladribine in the treatment of chronic lymphocytic leukemia: a 10-year experience in Poland. | Annals of hematology 20050201 |
| Long-term analysis of the palliative benefit of 2-chlorodeoxyadenosine for myelofibrosis with myeloid metaplasia. | European journal of haematology 20050201 |
| Therapy of chronic lymphocytic leukemia with purine analogs and monoclonal antibodies. | Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 20050201 |
| Hairy cell leukemia: survival and relapse. Long-term follow-up of purine analog-based therapy and approach for relapsed disease. | Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 20050201 |
| Proapoptotic activity of alemtuzumab alone and in combination with rituximab or purine nucleoside analogues in chronic lymphocytic leukemia cells. | Leukemia & lymphoma 20050101 |
| Changes in leukemic cell nuclei revealed by differential scanning calorimetry. | Leukemia & lymphoma 20050101 |
| How we treat Waldenström's macroglobulinemia. | Haematologica 20050101 |
| Functional analysis of genetic variants in the human concentrative nucleoside transporter 3 (CNT3; SLC28A3). | The pharmacogenomics journal 20050101 |
| In vitro sensitivity of leukemic cells to nucleoside derivatives in childhood acute leukemias: good activity in leukemic relapses. | Neoplasma 20050101 |
| A2B adenosine receptor activity is reduced in neutrophils from patients with systemic sclerosis. | Arthritis research & therapy 20050101 |
| Application of population pharmacokinetics to cladribine. | BMC pharmacology 20050101 |
| Primary progressive multiple sclerosis : current and future treatment options. | CNS drugs 20050101 |
| Cytotoxic effects of cladribine and tezacitabine toward HL-60. | Acta biochimica Polonica 20050101 |
| Determination of caspase-3 activation fails to predict chemosensitivity in primary acute myeloid leukemia blasts. | BMC cancer 20050101 |
| Modern diagnosis and treatment of primary eosinophilia. | Acta haematologica 20050101 |
| Waldenström's macroglobulinemia. | Best practice & research. Clinical haematology 20050101 |
| Enhanced efficacy of gemcitabine in combination with anti-CD20 monoclonal antibody against CD20+ non-Hodgkin's lymphoma cell lines in vitro and in scid mice. | BMC cancer 20050101 |
| In B-CLL, the codon 72 polymorphic variants of p53 are not related to drug resistance and disease prognosis. | BMC cancer 20050101 |
| Efficient chemo-enzymatic syntheses of pharmaceutically useful unnatural 2'-deoxynucleosides. | Nucleosides, nucleotides & nucleic acids 20050101 |
| [Future possibilities of the multiple sclerosis treatment]. | Casopis lekaru ceskych 20050101 |
| Simultaneous quantification of fludarabine and cyclophosphamide in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry. | Rapid communications in mass spectrometry : RCM 20050101 |
| [Treatment results of Langerhans cell histiocytosis with LSH II protocol]. | Casopis lekaru ceskych 20050101 |
| Therapy of chronic lymphocytic leukaemia with purine nucleoside analogues: facts and controversies. | Drugs & aging 20050101 |
| Aggressive central nervous system demyelination in an adolescent. | Reviews in neurological diseases 20050101 |
| Synthesis and preliminary in vitro evaluation of 5'-O-esters of 2'-deoxyadenosine and 2-chloro-2'-deoxyadenosine with alpha-lipoic acid as potential prodrugs. | Acta poloniae pharmaceutica 20050101 |
| [Progress and perspectives in the treatment of systemic lupus erythematosus]. | Przeglad lekarski 20050101 |
| Adenine deoxynucleotides fludarabine and cladribine induce apoptosis in a CD95/Fas receptor, FADD and caspase-8-independent manner by activation of the mitochondrial cell death pathway. | Oncogene 20041216 |
| A phase I trial of gemcitabine plus cladribine in patients with advanced hematologic malignant diseases. | Cancer chemotherapy and pharmacology 20041201 |
| VH gene mutation status and cellular drug resistance in chronic lymphocytic leukaemia. | European journal of haematology 20041201 |
| Rituximab as treatment for minimal residual disease in hairy cell leukaemia. | European journal of haematology 20041201 |
| The influence of farnesyl protein transferase inhibitor R115777 (Zarnestra) alone and in combination with purine nucleoside analogs on acute myeloid leukemia progenitors in vitro. | European journal of haematology 20041201 |
| Transient complete atrioventricular block after cladribine administration. | International journal of cardiology 20041201 |
| [nhibitory effect of adenosine analogues on invasion of human ovarian cancer cell line HO-8910PM]. | Ai zheng = Aizheng = Chinese journal of cancer 20041201 |
| Treatment options in Waldenstrom's macroglobulinemia. | Clinical lymphoma 20041201 |
| Successful induction of long-term remission using rituximab in a patient with refractory hairy cell leukemia-Japanese variant. | International journal of hematology 20041201 |
| Management of patients with systemic mastocytosis: review of M. D. Anderson Cancer Center experience. | American journal of hematology 20041101 |
| Acquired factor VIII inhibitors in non-haemophilic patients: clinical experience of 15 cases. | Haemophilia : the official journal of the World Federation of Hemophilia 20041101 |
| The influence of chemotherapy on bone marrow in patients with chronic lymphocytic leukaemia. | Folia morphologica 20041101 |
| Farnesyltransferase inhibitor BMS-214662 induces apoptosis in B-cell chronic lymphocytic leukemia cells. | Leukemia 20041001 |
| Acute myeloid leukemia following treatment with cladribine for hairy cell leukemia: a case report and review of the literature. | Leukemia & lymphoma 20041001 |
| Cladribine: from the bench to the bedside--focus on hairy cell leukemia. | Expert review of anticancer therapy 20041001 |
| Durable response but prolonged cytopenia after cladribine treatment in relapsed patients with indolent non-Hodgkin's lymphomas: results of a Japanese phase II study. | International journal of hematology 20041001 |
| Selective increase of dATP pools upon activation of deoxycytidine kinase in lymphocytes: implications in apoptosis. | Nucleosides, nucleotides & nucleic acids 20041001 |
| Fluorescence studies of substrate binding to human recombinant deoxycytidine kinase. | Nucleosides, nucleotides & nucleic acids 20041001 |
| Stimulation of deoxycytidine kinase results in prolonged maintenance of the enzyme activity. | Nucleosides, nucleotides & nucleic acids 20041001 |
| Clofarabine in adult acute leukemias: clinical success and pharmacokinetics. | Nucleosides, nucleotides & nucleic acids 20041001 |
| Effects of 2-chloro-2'-deoxyadenosine on the cell cycle in the human leukemia EHEB cell line. | Nucleosides, nucleotides & nucleic acids 20041001 |
| Modulation of cytarabine induced cytotoxicity using novel deoxynucleoside analogs in the HL60 cell line. | Nucleosides, nucleotides & nucleic acids 20041001 |
| An update: 12-year follow-up of patients with hairy cell leukemia following treatment with 2-chlorodeoxyadenosine. | Leukemia 20040901 |
| Cutaneous adverse reaction to 2-chlorodeoxyadenosine with histological flame figures in patients with chronic lymphocytic leukaemia. | Journal of the European Academy of Dermatology and Venereology : JEADV 20040901 |
| Characterization of a gemcitabine-resistant murine leukemic cell line: reversion of in vitro resistance by a mononucleotide prodrug. | Clinical cancer research : an official journal of the American Association for Cancer Research 20040815 |
| Influence of 2-chlorodeoxyadenosine (cladribine) on human erythrocytes. | The international journal of biochemistry & cell biology 20040801 |
| Electrophysiological characterization of a recombinant human Na+-coupled nucleoside transporter (hCNT1) produced in Xenopus oocytes. | The Journal of physiology 20040801 |
| Role of low-dose 2-CdA in refractory or resistant lymphoplasmocytic lymphoma. | Journal of chemotherapy (Florence, Italy) 20040801 |
| Mechanisms of cross-resistance between nucleoside analogues and vincristine or daunorubicin in leukemic cells. | Biochemical and biophysical research communications 20040730 |
| Cytotoxicity and pharmacokinetics of cladribine metabolite, 2-chloroadenine in patients with leukemia. | Cancer letters 20040716 |
| Metabolic response patterns of nucleotides in B-cell chronic lymphocytic leukaemias to cladribine, fludarabine and deoxycoformycin. | Leukemia research 20040701 |
| Efficacy of continuous infusion 2-CDA (cladribine) in pediatric patients with Langerhans cell histiocytosis. | Pediatric blood & cancer 20040701 |
| Activation of deoxycytidine kinase by protein kinase inhibitors and okadaic acid in leukemic cells. | Biochemical pharmacology 20040701 |
| Factors affecting bryostatin 1-enhanced 2-CdA cytotoxicity in resistant B-cell chronic lymphocytic leukemia. | International journal of molecular medicine 20040701 |
| ['Smoldering systemic mastocytosis. 'Successful therapy with cladribine]. | Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20040701 |
| [Mastocytosis: advances in molecular diagnosis and therapeutics]. | Annales pharmaceutiques francaises 20040701 |
| Allogeneic hematopoietic stem cell transplantation with a reduced-intensity conditioning regimen for treatment of metastatic renal cell carcinoma: single institution experience with a minimum 1-year follow-up. | Experimental hematology 20040701 |
| Advances in chemotherapy for chronic lymphocytic leukemia. | Seminars in hematology 20040701 |
| [Hairy cell leukemia therapy by cladribine]. | Nihon rinsho. Japanese journal of clinical medicine 20040701 |
| T(11;18)-bearing pulmonary mucosa-associated lymphoid tissue lymphoma responding to cladribine. | International journal of hematology 20040701 |
| Clinical trials for malignant lymphoma in Japan. | Japanese journal of clinical oncology 20040701 |
| Upon drug-induced apoptosis in lymphoma cells X-linked inhibitor of apoptosis (XIAP) translocates from the cytosol to the nucleus. | Leukemia & lymphoma 20040701 |
| [Cladribine monotherapy for patients with relapsed or refractory indolent non-Hodgkin lymphoma]. | [Rinsho ketsueki] The Japanese journal of clinical hematology 20040701 |
| Advances in the diagnosis and treatment of chronic lymphocytic leukemia. | Clinical advances in hematology & oncology : H&O 20040701 |
| Determination of the deoxycytidine kinase activity in cell homogenates with a non-radiochemical assay using reversed-phase high performance liquid chromatography; Identification of a novel metabolite of 2-chlorodeoxyadenosine. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040615 |
| High incidence of complications after 2-chloro-2'-deoxyadenosine combined with cyclophosphamide in patients with advanced lymphoproliferative malignancies. | Annals of hematology 20040601 |
| Interleukin-8 and RANTES levels in patients with relapsing-remitting multiple sclerosis (RR-MS) treated with cladribine. | Acta neurologica Scandinavica 20040601 |
| Treatment of Erdheim-Chester disease with cladribine: a rational approach. | The British journal of ophthalmology 20040601 |
| Edema of the eyelids and sclera after rituximab infusion for orbital MALT lymphoma. | Haematologica 20040601 |
| [Successful induction and complete improvement of myelofibrosis and erythema nosodum with cladribine in a case of hairy cell leukemia]. | Gan to kagaku ryoho. Cancer & chemotherapy 20040601 |
| Purine nucleoside antimetabolites in development for the treatment of cancer. | Current opinion in investigational drugs (London, England : 2000) 20040601 |
| Metabolism of the antineoplastic and immunosuppressive drug 2-CdA (Leustatin) in animals and humans. | Xenobiotica; the fate of foreign compounds in biological systems 20040601 |
| Richter's syndrome in the brain first manifested as an ischaemic stroke. | Leukemia & lymphoma 20040601 |
| Addition of cladribine to daunorubicin and cytarabine increases complete remission rate after a single course of induction treatment in acute myeloid leukemia. Multicenter, phase III study. | Leukemia 20040501 |
| Reduced-intensity stem cell transplantation from an HLA-identical sibling donor in patients with myeloid malignancies. | Bone marrow transplantation 20040501 |
| Purine nucleoside analogues and combination therapies in B-cell chronic lymphocytic leukemia: dawn of a new era. | Leukemia research 20040501 |
| Systemic mastocytosis: current concepts and treatment advances. | Current hematology reports 20040501 |
| [Hairy cell leukemia, Japanese variant, successfully treated with cladribine]. | [Rinsho ketsueki] The Japanese journal of clinical hematology 20040501 |
| Treatment of indolent non-Hodgkin's lymphoma with cladribine as single-agent therapy and in combination with mitoxantrone. | International journal of hematology 20040501 |
| Rituximab followed by cladribine in the treatment of heavily pretreated patients with indolent lymphoid malignancies. | Leukemia & lymphoma 20040501 |
| Epstein-Barr virus positive large B-cell lymphoma arising in a patient previously treated with Cladribine for hairy cell leukemia. | Leukemia & lymphoma 20040501 |
| Treatment of refractory neurosarcoidosis with cladribine. | The New England journal of medicine 20040422 |
| 2-Chloro-2'-deoxyadenosine synergistically enhances azidothymidine cytotoxicity in azidothymidine resistant T-lymphoid cells. | Biochemical and biophysical research communications 20040402 |
| Feasibility of reduced intensity hematopoietic stem cell transplantation from an HLA-matched unrelated donor. | Bone marrow transplantation 20040401 |
| Occurrence of a myelodysplastic syndrome (MDS) during first-line 2-chloro-deoxyadenosine (2-CDA) treatment of a low-grade gastrointestinal MALT lymphoma. Case report and review of the literature. | Haematologica 20040401 |
| Safety of rituximab therapy during the first trimester of pregnancy: a case history. | European journal of haematology 20040401 |
| Phase II trial of cladribine and cytarabine in relapsed or refractory myeloid malignancies. | Leukemia research 20040401 |
| Treatment of systemic mast cell disease: beyond interferon. | Leukemia research 20040301 |
| In vitro drug-resistance profile in infant acute lymphoblastic leukemia in relation to age, MLL rearrangements and immunophenotype. | Leukemia 20040301 |
| Determination of the in vivo effects of cladribine alone and its combination with cyclophosphamide or cyclophosphamide and mitoxantrone on Bax and Bcl-2 protein expression in B-CLL cells. | Oncology reports 20040301 |
| Long-term follow-up of front-line treatment of hairy cell leukemia with 2-chlorodeoxyadenosine. | Haematologica 20040301 |
| Activation of deoxycytidine kinase in lymphocytes is calcium dependent and involves a conformational change detectable by native immunostaining. | Biochemical pharmacology 20040301 |
| 2-Chloro-2'-deoxyadenosine: alteration of DNA:TATA element binding protein (TBP) interactions. | Journal of molecular modeling 20040201 |
| Cladribine activity in systemic mast cell disease: application of biochemistry in the modern era of molecular biology. | Leukemia research 20040201 |
| Treatment of systemic mast cell disease with 2-chlorodeoxyadenosine. | Leukemia research 20040201 |
| Second malignancies and Richter's syndrome in patients with chronic lymphocytic leukaemia treated with cladribine. | European journal of cancer (Oxford, England : 1990) 20040201 |
| Ex vivo drug resistance in childhood acute myeloid leukemia on relapse is not higher than at first diagnosis. | Pediatric blood & cancer 20040201 |
| Antitumor activity of sugar-modified cytosine nucleosides. | Cancer science 20040201 |
| Treatment of advanced mycosis fungoides/Sézary syndrome with fludarabine and potential adjunctive benefit to subsequent extracorporeal photochemotherapy. | The British journal of dermatology 20040201 |
| Clinical, genetic, and therapeutic insights into systemic mast cell disease. | Current opinion in hematology 20040101 |
| The antileukemia drug 2-chloro-2'-deoxyadenosine: an intrinsic transcriptional antagonist. | Molecular pharmacology 20040101 |
| Cladribine followed by autologous stem-cell transplantation in progressive multiple sclerosis. | Internal medicine journal 20040101 |
| Development of early neutropenic fever, with or without bacterial infection, is still a significant complication after reduced-intensity stem cell transplantation. | Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20040101 |
| Effect of 2-chlorodeoxyadenosine therapy on bone marrow fibrosis in hairy cell leukemia. | Neoplasma 20040101 |
| [Bone marrow fibrosis during therapy of hairy cell leukemia]. | Ceskoslovenska patologie 20040101 |
| Successful treatment of cutaneous langerhans cell histiocytosis with thalidomide. | Dermatology (Basel, Switzerland) 20040101 |
| Successful pregnancy after cladribine therapy for hairy cell leukemia. | Leukemia & lymphoma 20040101 |
| Alemtuzumab (Campath 1H) in hairy cell leukaemia relapsing after rituximab treatment. | The hematology journal : the official journal of the European Haematology Association 20040101 |
| Translocation t(11;18)(q21;q21) is not predictive of response to chemotherapy with 2CdA in patients with gastric MALT lymphoma. | Oncology 20040101 |
| Purine analogs in leukemia. | Advances in pharmacology (San Diego, Calif.) 20040101 |
| Acute respiratory failure associated with cladribine pneumonitis. | Internal medicine journal 20040101 |
| Evidence-based evaluation of immunomodulatory therapy for the cutaneous manifestations of lupus. | Advances in dermatology 20040101 |
| The influence of 2-chlorodeoxyadenosine (2-CdA) on the adenine energy charge and glutathione content of human erythrocytes. | Cell biology international 20040101 |
| 2-Chlorodeoxyadenosine alone and in combination with cyclophosphamide and mitoxantrone induce apoptosis in B chronic lymphocytic leukemia cells in vivo. | Cancer detection and prevention 20040101 |
| Histomorphometry of nuclei of proximal convoluted tubules epithelium of kidney of experimental animals after Cladribine (2-CdA) administration. | Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina 20040101 |
| Histomorphology of renal corpuscles of kidney of experimental animals after Cladribine (2-CdA) administration. | Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina 20040101 |
| Histomorphology of renal proximal convoluted tubules of kidney of experimental animals after Cladribine (2-CdA) administration. | Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina 20040101 |
| The ultrastructure of kidney renal corpuscles of experimental animals after Cladribine (2-CdA) administration. | Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina 20040101 |
| Ultrastructure of kidney renal proximal convoluted tubules of experimental animals after Cladribine (2-CdA) administration. | Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina 20040101 |
| Cladribine therapy for systemic mastocytosis. | Blood 20031215 |
| Increased remissions from one course for intermediate-dose cytosine arabinoside and idarubicin in elderly acute myeloid leukaemia when combined with cladribine. A randomized population-based phase II study. | British journal of haematology 20031201 |
| Prospective randomised phase II study of gemcitabine at standard or fixed dose rate schedule in unresectable hepatocellular carcinoma. | British journal of cancer 20031117 |
| Epstein-Barr virus-associated B-cell non-Hodgkin lymphoma following treatment of hairy cell leukemia with cladribine. | Blood 20031101 |
| Chronic myelomonocytic leukemia coexisting with B-cell chronic lymphocytic leukemia. | Leukemia & lymphoma 20031101 |
| Hairy cell leukemia and sarcoidosis: a case report and review of the literature. | Leukemia 20031001 |
| Mast cell proliferative disorders: current view on variants recognized by the World Health Organization. | Hematology/oncology clinics of North America 20031001 |
| [Immunohistochemical detection and quantification of minimal residual disease using DBA.44 antibodies in trephination biopsies of hairy cell leukemia]. | Ceskoslovenska patologie 20031001 |
| Pharmacological basis for cladribine resistance. | Leukemia & lymphoma 20031001 |
| A multicenter, open, non-comparative, phase II study of the combination of cladribine (2-chlorodeoxyadenosine), cytarabine, and G-CSF as induction therapy in refractory acute myeloid leukemia - a report of the Polish Adult Leukemia Group (PALG). | European journal of haematology 20030901 |
| Cutaneous reactions in hairy cell leukaemia treated with 2-chlorodeoxyadenosine and allopurinol. | British journal of haematology 20030901 |
| Synergistic effects of chemotherapeutic drugs in lymphoma cells are associated with down-regulation of inhibitor of apoptosis proteins (IAPs), prostate-apoptosis-response-gene 4 (Par-4), death-associated protein (Daxx) and with enforced caspase activation. | Biochemical pharmacology 20030901 |
| [Treatment of systemic mastocytosis]. | La Revue de medecine interne 20030901 |
| Immune reconstitution following reduced-intensity transplantation with cladribine, busulfan, and antithymocyte globulin: serial comparison with conventional myeloablative transplantation. | Bone marrow transplantation 20030901 |
| Disseminated zygomycosis: a rare cause of infection in patients with hematologic malignancies. | The Journal of trauma 20030901 |
| The influence of imatinib mesylate (STI571) used alone or in combination with purine nucleoside analogues on the normal and chronic myelogenous leukaemia progenitor cells in vitro. | Leukemia & lymphoma 20030901 |
| Effect of Aplidin in acute lymphoblastic leukaemia cells. | British journal of cancer 20030818 |
| Phase 2 study of rituximab in the treatment of cladribine-failed patients with hairy cell leukemia. | Blood 20030801 |
| Mitoxantrone and cytarabine induction, high-dose cytarabine, and etoposide intensification for pediatric patients with relapsed or refractory acute myeloid leukemia: Children's Cancer Group Study 2951. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030801 |
| Functional expression and characterization of a sodium-dependent nucleoside transporter hCNT2 cloned from human duodenum. | Biochemical and biophysical research communications 20030801 |
| Mantle cell lymphoma. | Current treatment options in oncology 20030801 |
| Hairy cell leukemia: an update. | Current opinion in hematology 20030701 |
| Diabetes insipidus and Langerhans cell histiocytosis: a case report of reversibility with 2-chlorodeoxyadenosine. | Journal of pediatric hematology/oncology 20030701 |
| Hairy cell leukaemia with advanced treatment - a case report. | Mymensingh medical journal : MMJ 20030701 |
| Role of IMP-selective 5'-nucleotidase (cN-II) in hematological malignancies. | Leukemia & lymphoma 20030701 |
| Increased sensitivity to gemcitabine of P-glycoprotein and multidrug resistance-associated protein-overexpressing human cancer cell lines. | British journal of cancer 20030616 |
| A key role for caspase-2 and caspase-3 in the apoptosis induced by 2-chloro-2'-deoxy-adenosine (cladribine) and 2-chloro-adenosine in human astrocytoma cells. | Molecular pharmacology 20030601 |
| Doxorubicin-resistant, MRP1-expressing U-1285 cells are sensitive to idarubicin. | Therapeutic drug monitoring 20030601 |
| Mechanism of action of purine analogues in chronic lymphocytic leukaemia. | British journal of haematology 20030601 |
| Gastrointestinal involvement in disseminated Langerhans cell histiocytosis (LCH) with durable complete response to 2-chlorodeoxyadenosine and high-dose cytarabine. | Journal of pediatric hematology/oncology 20030601 |
| Phase II study of cladribine (2-chlorodeoxyadenosine) in relapsed or refractory adult T-cell leukemia-lymphoma. | International journal of hematology 20030601 |
| Development of hairy cell leukemia in a patient treated with cytoreductive agents for essential thrombocythemia. | Leukemia & lymphoma 20030601 |
| Effect of gamma-irradiation on cladribine and cladribine-containing biodegradable copolymers. | Journal of controlled release : official journal of the Controlled Release Society 20030520 |
| Marked increase in serum IgM during treatment of Waldenstrom's macroglobulinemia with cladribine. | The New England journal of medicine 20030515 |
| Waldenstrom's macroglobulinemia: is there a place and time for a cease-fire? | Leukemia research 20030501 |
| Successful treatment of a patient with hairy cell leukemia and pentostatin-induced autoimmune thrombocytopenia with rituximab. | American journal of hematology 20030501 |
| Fighting leukemia. Survival rates have tripled thanks to new, more effective treatments. | Mayo Clinic women's healthsource 20030501 |
| Hodgkin's type of Richter's syndrome in familial chronic lymphocytic leukemia treated with cladribine and cyclophosphamide. | Leukemia & lymphoma 20030501 |
| Regulation of hairy-cell survival through constitutive activation of mitogen-activated protein kinase pathways. | Oncogene 20030417 |
| Indolent neuroendocrine tumor involving the bone marrow. A case report with a 9-year follow-up. | Archives of pathology & laboratory medicine 20030401 |
| Hairy cell leukemia variant developing in a background of polycythemia vera. | Archives of pathology & laboratory medicine 20030401 |
| Impact of graft-versus-host disease in reduced-intensity stem cell transplantation (RIST) for patients with haematological malignancies. | British journal of haematology 20030401 |
| Treatment recommendations in Waldenstrom's macroglobulinemia: consensus panel recommendations from the Second International Workshop on Waldenstrom's Macroglobulinemia. | Seminars in oncology 20030401 |
| 2-Chlorodeoxyadenosine alone and in combination for previously untreated Waldenstrom's macroglobulinemia. | Seminars in oncology 20030401 |
| Hairy cell leukemia with concurrent cryptococcus infection. | American journal of hematology 20030301 |
| Extended follow-up of patients with hairy cell leukemia after treatment with cladribine. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030301 |
| Expression of deoxycytidine kinase in leukaemic cells compared with solid tumour cell lines, liver metastases and normal liver. | European journal of cancer (Oxford, England : 1990) 20030301 |
| 2-Chlorodeoxyadenosine therapy for disseminated Langerhans cell histiocytosis. | Mayo Clinic proceedings 20030301 |
| Comparison of cytotoxicity of 2-chloro- 2'-arabino-fluoro-2'-deoxyadenosine (clofarabine) with cladribine in mononuclear cells from patients with acute myeloid and chronic lymphocytic leukemia. | Haematologica 20030301 |
| The variant form of hairy-cell leukaemia. | Best practice & research. Clinical haematology 20030301 |
| Splenectomy and treatments of historical interest. | Best practice & research. Clinical haematology 20030301 |
| Interferon in the treatment of hairy-cell leukemia. | Best practice & research. Clinical haematology 20030301 |
| Hairy-cell leukaemia as a model for drug development. | Best practice & research. Clinical haematology 20030301 |
| Cladribine in the treatment of hairy-cell leukaemia. | Best practice & research. Clinical haematology 20030301 |
| Immunobiological treatments of hairy-cell leukaemia. | Best practice & research. Clinical haematology 20030301 |
| Purine nucleoside analogues in the treatment of myleoid leukemias. | Leukemia & lymphoma 20030301 |
| Successful treatment of Langerhans cell histiocytosis with 2-chlorodeoxyadenosine. | Respirology (Carlton, Vic.) 20030301 |
| Efficient syntheses of 2-chloro-2'-deoxyadenosine (cladribine) from 2'-deoxyguanosine(1). | The Journal of organic chemistry 20030207 |
| Efficacy of 2-chlorodeoxyadenosine in refractory factor VIII inhibitors in persons without hemophilia. | Blood 20030201 |
| Advances in the treatment of hairy-cell leukaemia. | The Lancet. Oncology 20030201 |
| A phase II study of cladribine treatment for fludarabine refractory B cell chronic lymphocytic leukemia: results from CALGB Study 9211. | Leukemia 20030201 |
| [Cladribine]. | Gan to kagaku ryoho. Cancer & chemotherapy 20030201 |
| Alkaline hydrolysis of cladribine. | Die Pharmazie 20030201 |
| CD4+ CD56+ neoplasia: clinical and biological features with emphasis on cytotoxic drug-induced apoptosis and expression of sialyl Lewis X. | Leukemia & lymphoma 20030201 |
| Synthesis and induction of apoptosis in B cell chronic leukemia by diosgenyl 2-amino-2-deoxy-beta-D-glucopyranoside hydrochloride and its derivatives. | Carbohydrate research 20030120 |
| The effects of cladribine and fludarabine on DNA methylation in K562 cells. | Biochemical pharmacology 20030115 |
| Down-regulation of deoxycytidine kinase in human leukemic cell lines resistant to cladribine and clofarabine and increased ribonucleotide reductase activity contributes to fludarabine resistance. | Biochemical pharmacology 20030115 |
| Influence of p53 and p21(WAF1) expression on sensitivity of cancer cells to cladribine. | Biochemical pharmacology 20030101 |
| Phase II study of cladribine and cyclophosphamide in patients with chronic lymphocytic leukemia and prolymphocytic leukemia. | Cancer 20030101 |
| Newer drugs for the treatment of lupus nephritis. | Drugs 20030101 |
| In AML cell lines Ara-C combined with purine analogues is able to exert synergistic as well as antagonistic effects on proliferation, apoptosis and disruption of mitochondrial membrane potential. | Leukemia & lymphoma 20030101 |
| The effect of cyclosporin A used alone and in combination with either 2-chlorodeoxyadenosine or fludarabine on normal and chronic myelogenous leukemia progenitors in vitro. | Archivum immunologiae et therapiae experimentalis 20030101 |
| Interventions for the prevention of brain atrophy in multiple sclerosis : current status. | CNS drugs 20030101 |
| p53 status and its in vitro relationship to radiosensitivity and chemosensitivity in lung cancer. | Anticancer research 20030101 |
| Nucleotide excision repair-deficient human cells in culture exhibit decreased survival after 2-chlorodeoxyadenosine treatment. | Anticancer research 20030101 |
| 2-Chloro-deoxyadenosine induces durable complete remission in Castleman's disease but may accelerate its transformation to non-Hodgkin's lymphoma. | Acta oncologica (Stockholm, Sweden) 20030101 |
| Hairy cell leukemia in father and son. | Medical oncology (Northwood, London, England) 20030101 |
| Treatment of cutaneous T-cell lymphomas with purine analogues (fludarabine and 2-chlorodeoxyadenosine). | Journal of B.U.ON. : official journal of the Balkan Union of Oncology 20030101 |
| Rituximab: a useful drug for a repeatedly relapsed hairy cell leukemia patient. | Annals of hematology 20021201 |
| [Immunosuppressive medication in multiple sclerosis]. | Revista de neurologia 20021201 |
| Relationships of in vitro sensitivities tested with nine drugs and two types of irradiation in chronic lymphocytic leukemia. | Leukemia research 20021101 |
| Cladribine induces immunophenotypical changes in bone marrow mast cells from mastocytosis. Report of a case of mastocytosis associated with a lymphoplasmacytic lymphoma. | Leukemia research 20021101 |
| Cellular drug resistance in childhood acute myeloid leukemia is related to chromosomal abnormalities. | Blood 20021101 |
| Pharmacokinetics of 2-chlorodeoxyadenosine in a child undergoing hemofiltration and hemodialysis for acute renal failure. | Journal of pediatric hematology/oncology 20021101 |
| Complete remission of chronic plaque psoriasis and gastric marginal zone B-cell lymphoma of MALT type after treatment with 2-chlorodeoxyadenosine. | Annals of hematology 20021101 |
| Cladribine in the treatment of IgM paraproteinemic polyneuropathy. | Neurology 20021022 |
| Interim comparison of a continuous infusion versus a short daily infusion of cytarabine given in combination with cladribine for pediatric acute myeloid leukemia. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20021015 |
| Role of caspases and apoptosis-inducing factor (AIF) in cladribine-induced apoptosis of B cell chronic lymphocytic leukemia. | Leukemia 20021001 |
| Successful treatment of leukaemia cutis with cladribine in a patient with B-cell chronic lymphocytic leukaemia. | The British journal of dermatology 20021001 |
| Treatment of hairy cell leukemia with cladribine (2-chlorodeoxyadenosine) by subcutaneous bolus injection: a phase II study. | Annals of oncology : official journal of the European Society for Medical Oncology 20021001 |
| [Pulmonary localization of hairy cell leukemia]. | La Revue de medecine interne 20021001 |
| Langerhans cell histiocytosis in a patient with systemic lupus erythematosus: a clonal disease responding to treatment with cladribine, and cyclophosphamide. | Leukemia & lymphoma 20021001 |
| Treatment of extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type with cladribine: a phase II study. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020915 |
| Adenine and deazaadenine nucleoside and deoxynucleoside analogues: inhibition of viral replication of sheep MVV (in vitro model for HIV) and bovine BHV-1. | Bioorganic & medicinal chemistry 20020901 |
| Response of idiopathic hypereosinophilic syndrome to treatment with imatinib mesylate. | Leukemia research 20020901 |
| Waldenström's macroglobulinaemia. | Blood reviews 20020901 |
| Reduced-dose cladribine (2-CdA) plus mitoxantrone is effective in the treatment of mantle-cell and low-grade non-Hodgkin's lymphoma. | European journal of cancer (Oxford, England : 1990) 20020901 |
| B-chronic lymphocytic leukemia: practical aspects. | Hematological oncology 20020901 |
| Cytotoxic effect of cyclosporin A alone and in combination with 2-chlorodeoxyadenosine against P388 murine leukemia in vivo. | Medical science monitor : international medical journal of experimental and clinical research 20020901 |
| [The BCTRIMS Expanded Consensus on treatment of multiple sclerosis: I. The evidences for the use of immunosuppressive agents, plasma exchange and autologous hematopoietic stem cell transplantation]. | Arquivos de neuro-psiquiatria 20020901 |
| Evaluation of apoptosis induced in vitro by cladribine (2-CdA) combined with anthracyclines in lymphocytes from patients with B-cell chronic lymphocytic leukemia. | Annals of hematology 20020901 |
| Ex vivo drug resistance profile in childhood acute myelogenous leukemia: no drug is more effective in comparison to acute lymphoblastic leukemia. | Leukemia & lymphoma 20020901 |
| Specificity of human and rat orthologs of the concentrative nucleoside transporter, SPNT. | American journal of physiology. Renal physiology 20020801 |
| Simultaneous diagnosis of hairy cell leukemia and chronic lymphocytic leukemia/small lymphocytic lymphoma: a frequent association? | Leukemia 20020801 |
| Bendamustine in the treatment of chronic lymphocytic leukemia: results and future perspectives. | Seminars in oncology 20020801 |
| Systemic vasculitis complicating hairy cell leukaemia treatment with cladribine. | Clinical and laboratory haematology 20020801 |
| 2-chloro-2'-deoxyadenosine in the treatment of Sjögren's syndrome-associated B cell lymphoproliferation. | Arthritis and rheumatism 20020801 |
| Successful treatment with 2-chlorodeoxyadenosine of secondary lesions of the central nervous system in low-grade lymphoid malignancies. | American journal of hematology 20020801 |
| [Immunosuppressants and multiple sclerosis]. | Revista de neurologia 20020801 |
| Waldenström's macroglobulinemia: a review of therapy. | Leukemia & lymphoma 20020801 |
| Mini-transplantation strategy for solid tumors. | International journal of hematology 20020801 |
| Evolving role of ribonucleoside reductase inhibitors in hematologic malignancies. | Expert review of anticancer therapy 20020801 |
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| Widespread skin-limited adult Langerhans cell histiocytosis: long-term follow-up with good response to interferon alpha. | Clinical and experimental dermatology 20020301 |
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