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Home > Nitro Compounds > 42397-64-8
42397-64-8 | 1,6-Dinitropyrene
CAS No: 42397-64-8 Catalog No: AG003DRD MDL No:
Product Description
Catalog Number:
AG003DRD
Chemical Name:
1,6-Dinitropyrene
CAS Number:
42397-64-8
IUPAC Name:
1,6-dinitropyrene
InChI:
InChI=1S/C16H8N2O4/c19-17(20)13-8-4-10-2-6-12-14(18(21)22)7-3-9-1-5-11(13)16(10)15(9)12/h1-8H
InChI Key:
GUXACCKTQWVTLG-UHFFFAOYSA-N
UNII:
66Q2ZUF83N
Properties
Complexity:
442
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
292.048g/mol
Formal Charge:
0
Heavy Atom Count:
22
Hydrogen Bond Acceptor Count:
4
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
292.25g/mol
Monoisotopic Mass:
292.048g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
91.6A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4.7
Literature
| Title | Journal |
|---|---|
| Mechanistic Investigations Into the Developmental Toxicity of Nitrated and Heterocyclic PAHs. | Toxicological sciences : an official journal of the Society of Toxicology 20170501 |
| A new imidazolium-embedded C18 stationary phase with enhanced performance in reversed-phase liquid chromatography. | Analytica chimica acta 20120813 |
| Environmental nitration processes enhance the mutagenic potency of aromatic compounds. | Environmental toxicology 20120501 |
| Metabolic activation of diesel exhaust carcinogens in primary and immortalized human TP53 knock-in (Hupki) mouse embryo fibroblasts. | Environmental and molecular mutagenesis 20120401 |
| Health and cellular impacts of air pollutants: from cytoprotection to cytotoxicity. | Biochemistry research international 20120101 |
| Impact of a NO₂-regenerated diesel particulate filter on PAH and NPAH emissions from an EURO IV heavy duty engine. | Journal of environmental monitoring : JEM 20111201 |
| Nitroarenes (selected): 1,6-Dinitropyrene. | Report on carcinogens : carcinogen profiles 20110101 |
| Mutagenicity of surface soil from residential areas in Kyoto city, Japan, and identification of major mutagens. | Mutation research 20080108 |
| Effects of nitrated-polycyclic aromatic hydrocarbons and diesel exhaust particle extracts on cell signalling related to apoptosis: possible implications for their mutagenic and carcinogenic effects. | Toxicology 20070307 |
| Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods. | Journal of molecular graphics & modelling 20061101 |
| Nitrocompound activation by cell-free extracts of nitroreductase-proficient Salmonella typhimurium strains. | Mutagenesis 20061101 |
| In vivo mutagenesis in the lungs of gpt-delta transgenic mice treated intratracheally with 1,6-dinitropyrene. | Environmental and molecular mutagenesis 20060501 |
| Oxidative DNA damage induced by carcinogenic dinitropyrenes in the presence of P450 reductase. | Chemical research in toxicology 20041201 |
| Nitroarenes (selected) 1,6-dinitropyrene. | Report on carcinogens : carcinogen profiles 20040101 |
| Mutagenic activity and quantification of nitroarenes in surface soil in the Kinki region of Japan. | Mutation research 20030708 |
| Improvement of an automatic HPLC system for nitropolycyclic aromatic hydrocarbons: removal of an interfering peak and increase in the number of analytes. | Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20030201 |
| Comparative mutagenesis of the C8-guanine adducts of 1-nitropyrene and 1,6- and 1,8-dinitropyrene in a CpG repeat sequence. A slipped frameshift intermediate model for dinucleotide deletion. | The Journal of biological chemistry 20021122 |
| Induction of CYP1A1, CYP1A2, and CYP1B1 mRNAs by nitropolycyclic aromatic hydrocarbons in various human tissue-derived cells: chemical-, cytochrome P450 isoform-, and cell-specific differences. | Archives of toxicology 20020601 |
| Salmonella typhimurium mutagenicity tester strains that overexpress oxygen-insensitive nitroreductases nfsA and nfsB. | Mutation research 20020425 |
| DNA adducts from nitroreduction of 2,7-dinitrofluorene, a mammary gland carcinogen, catalyzed by rat liver or mammary gland cytosol. | Chemical research in toxicology 20020401 |
| Dinitropyrenes induce gene mutations in multiple organs of the lambda/lacZ transgenic mouse (Muta Mouse). | Mutation research 20020325 |
| Nitroarenes (selected). 1,6-Dinitropyrene. | Report on carcinogens : carcinogen profiles 20020101 |
| Cellular determinants of the mutational specificity of 1-nitroso-6-nitropyrene and 1-nitroso-8-nitropyrene in the lacI gene of Escherichia coli. | Mutation research 20011212 |
| [Suppression of frameshift mutation as a result of partial inactivation of translation termination factors in Saccharomyces cerevisiae yeast]. | Genetika 20010501 |
| Cytochrome P450 induction by nitrated polycyclic aromatic hydrocarbons, azaarenes, and binary mixtures in fish hepatoma cell line PLHC-1. | Environmental toxicology and chemistry 20010101 |
| Bioactivation of diesel exhaust particle extracts and their major nitrated polycyclic aromatic hydrocarbon components, 1-nitropyrene and dinitropyrenes, by human cytochromes P450 1A1, 1A2, and 1B1. | Mutation research 20001220 |
| Carcinogenicity of nitropyrenes in the newborn female rat. | Carcinogenesis 19951201 |
| Toxicity of monocyclic and polycyclic nitroaromatic compounds in a panel of mammalian test cell lines. | Toxicology letters 19940601 |
| Comparative reduction of 1-nitro-3-nitrosopyrene and 1-nitro-6-nitrosopyrene: implications for the tumorigenicity of dinitropyrenes. | Cancer letters 19920731 |
| Decreased clastogenicity of dinitropyrenes in Chinese hamster lung (CHL) subclone cells with low NADPH-cytochrome P-450 reductase activity. | Mutation research 19910901 |
| Carcinogenicity of dinitropyrenes in the weanling female CD rat. | Carcinogenesis 19910701 |
| Purified NAD(P)H-quinone oxidoreductase enhances the mutagenicity of dinitropyrenes in vitro. | Journal of biochemical toxicology 19910101 |
| Inactivation of 1,3-, 1,6-, and 1,8-dinitropyrene by cytochrome P-450 enzymes in human and rat liver microsomes. | Cancer research 19900401 |
| Metabolism and biological effects of nitropyrene and related compounds. | Research report (Health Effects Institute) 19880201 |
| Tumorigenicity of nitrated derivatives of pyrene, benz[a]anthracene, chrysene and benzo[a]pyrene in the newborn mouse assay. | Carcinogenesis 19860801 |
| Dinitro derivatives of pyrene and fluoranthene in diesel emission particulates and their tumorigenicity in mice and rats. | Developments in toxicology and environmental science 19860101 |
| Carcinogenic effects of a mixture of nitropyrenes in F344 rats following its repeated oral administrations. | Developments in toxicology and environmental science 19860101 |
| Induction of 6-thioguanine resistance, chromosome aberrations and SCE by dinitropyrenes in Chinese hamster ovary cells in vitro. | Mutation research 19851201 |
| Absence of carcinogenicity of 1-nitropyrene, correction of previous results, and new demonstration of carcinogenicity of 1,6-dinitropyrene in rats. | Cancer letters 19850101 |
| Tumor initiating activities of 1-nitropyrene and its nitrated products in SENCAR mice. | Cancer letters 19840501 |
| Mutagenicity of mono-, di- and tri-nitropyrenes in Chinese hamster ovary cells. | Mutation research 19830301 |
| The clastogenic activity of dinitropyrenes in a rat-liver epithelial cell line. | Mutation research 19821101 |
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