200,000+ products from a single source!
sales@angenechem.com
Home > Other Building Blocks > 4143-62-8
4143-62-8 | 2-(3,4-Dimethoxyphenyl)-4H-chromen-4-one
CAS No: 4143-62-8 Catalog No: AG003II7 MDL No:MFCD00143009
Product Description
Catalog Number:
AG003II7
Chemical Name:
2-(3,4-Dimethoxyphenyl)-4H-chromen-4-one
CAS Number:
4143-62-8
Molecular Formula:
C17H14O4
Molecular Weight:
282.2907
MDL Number:
MFCD00143009
IUPAC Name:
2-(3,4-dimethoxyphenyl)chromen-4-one
InChI:
InChI=1S/C17H14O4/c1-19-15-8-7-11(9-17(15)20-2)16-10-13(18)12-5-3-4-6-14(12)21-16/h3-10H,1-2H3
InChI Key:
ZGHORMOOTZTQFL-UHFFFAOYSA-N
SMILES:
COc1cc(ccc1OC)c1cc(=O)c2c(o1)cccc2
Properties
Complexity:
417
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
282.089g/mol
Formal Charge:
0
Heavy Atom Count:
21
Hydrogen Bond Acceptor Count:
4
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
282.295g/mol
Monoisotopic Mass:
282.089g/mol
Rotatable Bond Count:
3
Topological Polar Surface Area:
44.8A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.5
Literature
| Title | Journal |
|---|---|
| 3'-Hydroxy-3,4'-dimethoxyflavone-induced cell death in human leukaemia cells is dependent on caspases and reactive oxygen species and attenuated by the inhibition of JNK/SAPK. | Chemico-biological interactions 20180525 |
| Interleukin-24 as a target cytokine of environmental aryl hydrocarbon receptor agonist exposure in the lung. | Toxicology and applied pharmacology 20170601 |
| Dioxin-like rather than non-dioxin-like PCBs promote the development of endometriosis through stimulation of endocrine-inflammation interactions. | Archives of toxicology 20170401 |
| In vitro analysis of factors influencing CYP1A2 expression as potential determinants of interindividual variation. | Pharmacology research & perspectives 20170401 |
| Baicalin Protects Mice from Aristolochic Acid I-Induced Kidney Injury by Induction of CYP1A through the Aromatic Hydrocarbon Receptor. | International journal of molecular sciences 20150701 |
| The inflammation and estrogen metabolism impacts of polychlorinated biphenyls on endometrial cancer cells. | Toxicology in vitro : an international journal published in association with BIBRA 20150301 |
| Molecular mechanisms of cadmium-induced fibroblast growth factor 23 upregulation in osteoblast-like cells. | Toxicological sciences : an official journal of the Society of Toxicology 20140601 |
| The O-methylation of chrysin markedly improves its intestinal anti-inflammatory properties: Structure-activity relationships of flavones. | Biochemical pharmacology 20131215 |
| Estrogen receptor-hijacking by dioxin-like 3,3'4,4',5-pentachlorobiphenyl (PCB126) in salmon hepatocytes involves both receptor activation and receptor protein stability. | Aquatic toxicology (Amsterdam, Netherlands) 20121115 |
| Flavonoids exhibit diverse effects on CYP11B1 expression and cortisol synthesis. | Toxicology and applied pharmacology 20120201 |
| Benzyl butyl phthalate induces necrosis by AhR mediation of CYP1B1 expression in human granulosa cells. | Reproductive toxicology (Elmsford, N.Y.) 20120101 |
| Methysticin and 7,8-dihydromethysticin are two major kavalactones in kava extract to induce CYP1A1. | Toxicological sciences : an official journal of the Society of Toxicology 20111201 |
| Genotoxicity and apoptosis in Drosophila melanogaster exposed to benzene, toluene and xylene: attenuation by quercetin and curcumin. | Toxicology and applied pharmacology 20110515 |
| Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives. | Chemical research in toxicology 20101220 |
| Aryl hydrocarbon receptor antagonists attenuate the deleterious effects of benzo[a]pyrene on isolated rat follicle development. | Reproductive biomedicine online 20100701 |
| Amino acid substitutions in the aryl hydrocarbon receptor ligand binding domain reveal YH439 as an atypical AhR activator. | Molecular pharmacology 20100601 |
| Inhibition of procarcinogen-bioactivating human CYP1A1, CYP1A2 and CYP1B1 enzymes by melatonin. | Journal of pineal research 20100101 |
| Modulation of CYP1B1 and CYP1A1 gene expression and activation of aryl hydrocarbon receptor by Ginkgo biloba extract in MCF-10A human mammary epithelial cells. | Canadian journal of physiology and pharmacology 20090901 |
| Involvement of oxidative stress and activation of aryl hydrocarbon receptor in elevation of CYP1A1 expression and activity in lung cells and tissues by arsenic: an in vitro and in vivo study. | Toxicological sciences : an official journal of the Society of Toxicology 20090201 |
| Cytotoxic effects of the dietary flavones chrysin and apigenin in a normal trout liver cell line. | Chemico-biological interactions 20080110 |
| Polychlorinated biphenyl exposure and CYP19 gene regulation in testicular and adrenocortical cell lines. | Toxicology in vitro : an international journal published in association with BIBRA 20070901 |
| Novel methoxylated flavone inhibitors of cytochrome P450 1B1 in SCC-9 human oral cancer cells. | The Journal of pharmacy and pharmacology 20070601 |
| Cytochrome P450 1B1, a novel chemopreventive target for benzo[a]pyrene-initiated human esophageal cancer. | Cancer letters 20070208 |
| Inhibition of benzo[a]pyrene-activating enzymes and DNA binding in human bronchial epithelial BEAS-2B cells by methoxylated flavonoids. | Carcinogenesis 20060801 |
| Methylation protects dietary flavonoids from rapid hepatic metabolism. | Xenobiotica; the fate of foreign compounds in biological systems 20060501 |
| Mechanistic study of polychlorinated biphenyl 126-induced CYP11B1 and CYP11B2 up-regulation. | Endocrinology 20060301 |
| Preferential induction of CYP1B1 by benzo[a]pyrene in human oral epithelial cells: impact on DNA adduct formation and prevention by polyphenols. | Carcinogenesis 20051001 |
| Lipophilic flavones of Primula veris L. from field cultivation and in vitro cultures. | Phytochemistry 20050501 |
| Formation of estrogenic metabolites of benzo[a]pyrene and chrysene by cytochrome P450 activity and their combined and supra-maximal estrogenic activity. | Environmental toxicology and pharmacology 20050101 |
| Reversal of P-glycoprotein-mediated MDR by 5,7,3',4',5'-pentamethoxyflavone and SAR. | Biochemical and biophysical research communications 20040730 |
| MAPK signaling pathways modulate IL-1beta expression in human keratinocytes. | Archives of biochemistry and biophysics 20040401 |
| Tricin from a malagasy connaraceous plant with potent antihistaminic activity. | Journal of natural products 20030901 |
| Flavonolignan and flavone inhibitors of a Staphylococcus aureus multidrug resistance pump: structure-activity relationships. | Journal of medicinal chemistry 20010118 |
| 3',4'-dimethoxyflavone as an aryl hydrocarbon receptor antagonist in human breast cancer cells. | Toxicological sciences : an official journal of the Society of Toxicology 20001201 |
Related Products
Featured Products
© 2019 Angene International Limited. All rights Reserved.