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38989-38-7 | Dibenzo[a,g]quinolizinium,2,3,10,11-tetramethoxy-8-methyl-, chloride (1:1)
CAS No: 38989-38-7 Catalog No: AG00772E MDL No:
Product Description
Catalog Number:
AG00772E
Chemical Name:
Dibenzo[a,g]quinolizinium,2,3,10,11-tetramethoxy-8-methyl-, chloride (1:1)
CAS Number:
38989-38-7
Molecular Formula:
C22H23NO4
Molecular Weight:
365.4223
IUPAC Name:
2,3,10,11-tetramethoxy-8-methylisoquinolino[2,1-b]isoquinolin-7-ium;chloride
InChI:
InChI=1S/C22H22NO4.ClH/c1-13-16-11-21(26-4)20(25-3)10-15(16)8-18-17-12-22(27-5)19(24-2)9-14(17)6-7-23(13)18;/h6-12H,1-5H3;1H/q+1;/p-1
InChI Key:
PDYBUYVOPAJLKP-UHFFFAOYSA-M
SMILES:
COc1cc2c(cc1OC)C=c1n(C2C)ccc2c1cc(OC)c(c2)OC
EC Number:
254-239-2
Properties
Complexity:
503
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
399.124g/mol
Formal Charge:
0
Heavy Atom Count:
28
Hydrogen Bond Acceptor Count:
5
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
399.871g/mol
Monoisotopic Mass:
399.124g/mol
Rotatable Bond Count:
4
Topological Polar Surface Area:
41A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
| Title | Journal |
|---|---|
| A room-temperature adenosine-based molecular beacon for highly sensitive detection of nucleic acids. | Chemical communications (Cambridge, England) 20120625 |
| Therapeutic potential of nucleic acid-binding isoquinoline alkaloids: binding aspects and implications for drug design. | Medicinal research reviews 20111101 |
| Interaction of berberine, palmatine, coralyne, and sanguinarine to quadruplex DNA: a comparative spectroscopic and calorimetric study. | Biochimica et biophysica acta 20110401 |
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
| Cell-based and cytokine-directed chemical screen to identify potential anti-multiple myeloma agents. | Leukemia research 20100701 |
| Topoisomerase inhibitor coralyne photosensitizes DNA, leading to elicitation of Chk2-dependent S-phase checkpoint and p53-independent apoptosis in cancer cells. | Antioxidants & redox signaling 20100415 |
| Considerable change of fluorescence properties upon multiple binding of coralyne to 4-sulfonatocalixarenes. | The journal of physical chemistry. B 20100304 |
| Molecular recognition of poly(A) targeting by protoberberine alkaloids: in vitro biophysical studies and biological perspectives. | Molecular bioSystems 20100101 |
| RNA-binding potential of protoberberine alkaloids: spectroscopic and calorimetric studies on the binding of berberine, palmatine, and coralyne to protonated RNA structures. | DNA and cell biology 20091201 |
| Interaction of isoquinoline alkaloids with an RNA triplex: structural and thermodynamic studies of berberine, palmatine, and coralyne binding to poly(U).poly(A)(*)poly(U). | The journal of physical chemistry. B 20091008 |
| Interaction of isoquinoline alkaloids with polymorphic DNA structures. | Chemistry & biodiversity 20090901 |
| Dimer-promoted fluorescence quenching of coralyne by binding to anionic polysaccharides. | Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20090401 |
| Spectroscopic and calorimetric studies on the binding of alkaloids berberine, palmatine and coralyne to double stranded RNA polynucleotides. | The journal of physical chemistry. B 20090129 |
| Solvent effects on the thermodynamics and kinetics of coralyne self-aggregation. | The journal of physical chemistry. B 20090108 |
| DNA-binding cytotoxic alkaloids: comparative study of the energetics of binding of berberine, palmatine, and coralyne. | DNA and cell biology 20081201 |
| Molecular aspects on the interaction of protoberberine, benzophenanthridine, and aristolochia group of alkaloids with nucleic acid structures and biological perspectives. | Medicinal research reviews 20070901 |
| A gold nanoparticle based approach for screening triplex DNA binders. | Journal of the American Chemical Society 20060419 |
| Natural and synthetic G-quadruplex interactive berberine derivatives. | Bioorganic & medicinal chemistry letters 20060315 |
| Leishmania donovani: differential activities of classical topoisomerase inhibitors and antileishmanials against parasite and host cells at the level of DNA topoisomerase I and in cytotoxicity assays. | Experimental parasitology 20060101 |
| Efficient photoinduced DNA damage by coralyne. | Photochemistry and photobiology 20060101 |
| Molecular recognition of nucleic acids: coralyne binds strongly to poly(A). | FEBS letters 20050912 |
| Intercalation of organic dye molecules into double-stranded DNA. Part 2: the annelated quinolizinium ion as a structural motif in DNA intercalators. | Photochemistry and photobiology 20050101 |
| Assembly of an antiparallel homo-adenine DNA duplex by small-molecule binding. | Journal of the American Chemical Society 20040721 |
| Coralyne and related compounds as mammalian topoisomerase I and topoisomerase II poisons. | Bioorganic & medicinal chemistry 19960601 |
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