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38937-66-5 | N1,N8-Dihydroxyoctanediamide
CAS No: 38937-66-5 Catalog No: AG003UG3 MDL No:MFCD00192455
Product Description
Catalog Number:
AG003UG3
Chemical Name:
N1,N8-Dihydroxyoctanediamide
CAS Number:
38937-66-5
Molecular Formula:
C8H16N2O4
Molecular Weight:
204.2236
MDL Number:
MFCD00192455
IUPAC Name:
N,N'-dihydroxyoctanediamide
InChI:
InChI=1S/C8H16N2O4/c11-7(9-13)5-3-1-2-4-6-8(12)10-14/h13-14H,1-6H2,(H,9,11)(H,10,12)
InChI Key:
IDQPVOFTURLJPT-UHFFFAOYSA-N
SMILES:
ONC(=O)CCCCCCC(=O)NO
Properties
Complexity:
164
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
204.111g/mol
Formal Charge:
0
Heavy Atom Count:
14
Hydrogen Bond Acceptor Count:
4
Hydrogen Bond Donor Count:
4
Isotope Atom Count:
0
Molecular Weight:
204.226g/mol
Monoisotopic Mass:
204.111g/mol
Rotatable Bond Count:
7
Topological Polar Surface Area:
98.7A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-0.5
Literature
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| Altered histone acetylation is associated with age-dependent memory impairment in mice. | Science (New York, N.Y.) 20100507 |
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| Chemical phylogenetics of histone deacetylases. | Nature chemical biology 20100301 |
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| Hydroxamic acids as a novel family of serine racemase inhibitors: mechanistic analysis reveals different modes of interaction with the pyridoxal-5'-phosphate cofactor. | Journal of medicinal chemistry 20091008 |
| HDAC inhibitors, MS275 and SBHA, enhances cytotoxicity induced by oxaliplatin in the colorectal cancer cell lines. | Biochemical and biophysical research communications 20090918 |
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| Histone deacetylase inhibitors and a functional potent inhibitory effect on human uterine contractility. | American journal of obstetrics and gynecology 20080801 |
| Immobilised metal affinity chromatography for the capture of hydroxamate-containing siderophores and other Fe(III)-binding metabolites directly from bacterial culture supernatants. | The Analyst 20080701 |
| Scriptaid and suberoylanilide hydroxamic acid are histone deacetylase inhibitors with potent anti-Toxoplasma gondii activity in vitro. | The Journal of parasitology 20070601 |
| Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. | Nature chemical biology 20061001 |
| Human melanoma cells selected for resistance to apoptosis by prolonged exposure to tumor necrosis factor-related apoptosis-inducing ligand are more vulnerable to necrotic cell death induced by cisplatin. | Clinical cancer research : an official journal of the American Association for Cancer Research 20060215 |
| The histone deacetylase inhibitor suberic bishydroxamate regulates the expression of multiple apoptotic mediators and induces mitochondria-dependent apoptosis of melanoma cells. | Molecular cancer therapeutics 20040401 |
| Structure-activity relationships on phenylalanine-containing inhibitors of histone deacetylase: in vitro enzyme inhibition, induction of differentiation, and inhibition of proliferation in Friend leukemic cells. | Journal of medicinal chemistry 20020718 |
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