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36505-84-7

36505-84-7 | 8-Azaspiro[4.5]decane-7,9-dione,8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-

CAS No: 36505-84-7 Catalog No: AG00I78H MDL No:

Product Description

Catalog Number:
AG00I78H
Chemical Name:
8-Azaspiro[4.5]decane-7,9-dione,8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-
CAS Number:
36505-84-7
IUPAC Name:
8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione
InChI:
InChI=1S/C21H31N5O2/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9H,1-4,6-7,10-17H2
InChI Key:
QWCRAEMEVRGPNT-UHFFFAOYSA-N
EC Number:
253-072-2
UNII:
TK65WKS8HL

Properties

Complexity:
529  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
385.248g/mol
Formal Charge:
0
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
385.512g/mol
Monoisotopic Mass:
385.248g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
69.6A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.6  

Literature

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More questions than answers! Clinical dilemmas in psychopharmacology in pregnancy and lactation. Indian journal of psychiatry 20090101
A proposal for a pharmacokinetic interaction significance classification system (PISCS) based on predicted drug exposure changes and its potential application to alert classifications in product labelling. Clinical pharmacokinetics 20090101
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Towards achieving remission in the treatment of depression. Dialogues in clinical neuroscience 20081201
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Behavioral and pharmacological validation of the gerbil forced-swim test: effects of neurokinin-1 receptor antagonists. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20080701
Evidence of an enhanced central 5HT response in irritable bowel syndrome and in the rat maternal separation model. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20080601
Sustained-release of buspirone HCl by co spray-drying with aqueous polymeric dispersions. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20080601
In vitro assessment of mitochondrial dysfunction and cytotoxicity of nefazodone, trazodone, and buspirone. Toxicological sciences : an official journal of the Society of Toxicology 20080601
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Validating an Ataxia Functional Composite Scale in spinocerebellar ataxia. Journal of the neurological sciences 20080515
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Intranasal mucoadhesive buspirone formulation: in vitro characterization and nasal clearance studies. Die Pharmazie 20080501
Psychiatric issues in renal failure and dialysis. Indian journal of nephrology 20080401
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Variations in 123I-metaiodobenzylguanidine (MIBG) late heart mediastinal ratios in chronic heart failure: a need for standardisation and validation. European journal of nuclear medicine and molecular imaging 20080301
Additional evidence for anxiolytic- and antidepressant-like activities of saredutant (SR48968), an antagonist at the neurokinin-2 receptor in various rodent-models. Pharmacology, biochemistry, and behavior 20080301
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Quantitation of seven low-dosage antipsychotic drugs in human postmortem blood using LC-MS-MS. Journal of analytical toxicology 20080301
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Duration of ultrasonic vocalizations in the isolated rat pup as a behavioral measure: sensitivity to anxiolytic and antidepressant drugs. Pharmacology, biochemistry, and behavior 20080101
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Antagonism of phencyclidine-induced stimulus control in the rat by other psychoactive drugs. Pharmacology, biochemistry, and behavior 20080101
Comparison of the effects of deramciclane, ritanserin and buspirone on extracellular dopamine and its metabolites in striatum and nucleus accumbens of freely moving rats. Basic & clinical pharmacology & toxicology 20080101
Buspirone for autistic disorder in a woman with an intellectual disability. The Annals of pharmacotherapy 20080101
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Behavioral response to emotional stress in rabbits: role of serotonin and serotonin2A receptors. Behavioural pharmacology 20071101
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Neurotoxic syndrome developed after taking sertraline and risperidone. Journal of clinical neurology (Seoul, Korea) 20070901
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Unintentional onset of anorexia nervosa. Eating and weight disorders : EWD 20070601
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[Augmentation strategies for therapy resistant depression - a review]. Psychiatrische Praxis 20070501
Effects of citalopram treatment on hypothermic and hormonal responses to the 5-HT1A receptor agonist buspirone in patients with major depression and therapeutic response. Psychoneuroendocrinology 20070501
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Mania in a case of polypsychopharmacology: pharmacodynamic and pharmacokinetic considerations. Do you believe in magic? Journal of psychiatric practice 20070501
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Quantification of tricyclic antidepressants and monoamine oxidase inhibitors by high-performance liquid chromatography-tandem mass spectrometry in whole blood. Journal of analytical toxicology 20070501
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Modulation of L-DOPA-induced abnormal involuntary movements by clinically tested compounds: further validation of the rat dyskinesia model. Behavioural brain research 20070416
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Treatment of generalized anxiety disorder. Neuropsychiatric disease and treatment 20070401
Role of pregabalin in the treatment of generalized anxiety disorder. Neuropsychiatric disease and treatment 20070401
Quantitative and molecular analysis of buspirone hydrochloride polymorphs. Journal of pharmaceutical sciences 20070301
Differential effects of antipsychotic drugs on serotonin-1A receptor-mediated disruption of prepulse inhibition. The Journal of pharmacology and experimental therapeutics 20070301
Lack of deleterious effects of buspirone on cognition in healthy male volunteers. Journal of psychopharmacology (Oxford, England) 20070301
Reversal of haloperidol-induced extrapyramidal symptoms by buspirone: a time-related study. Behavioural pharmacology 20070301
Screening of 5-HT1A receptor antagonists using molecularly imprinted polymers. Journal of the American Chemical Society 20070214
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Interaction of the novel antipsychotic aripiprazole with 5-HT1A and 5-HT 2A receptors: functional receptor-binding and in vivo electrophysiological studies. Psychopharmacology 20070201
The effect of buspirone on normal and hypoarousal-driven abnormal aggression in rats. Progress in neuro-psychopharmacology & biological psychiatry 20070130
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Probable statin-induced testicular pain. The Annals of pharmacotherapy 20070101
Meperidine and skin surface warming additively reduce the shivering threshold: a volunteer study. Critical care (London, England) 20070101
Treating inhalant abuse with buspirone. The American journal on addictions 20070101
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The combination of buspirone and bupropion in the treatment of depression. Psychotherapy and psychosomatics 20070101
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Augmentation strategies to increase antidepressant efficacy. The Journal of clinical psychiatry 20070101
Medicinal importance of grapefruit juice and its interaction with various drugs. Nutrition journal 20070101
Bench-to-bedside review: mechanisms and management of hyperthermia due to toxicity. Critical care (London, England) 20070101
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[The role of serotonergic 2C receptors in neurobiology and treatment of eating disorders]. Psychiatrike = Psychiatriki 20070101
Anxiolytic activity of a novel potent serotonin 5-HT2C receptor antagonist FR260010: a comparison with diazepam and buspirone. European journal of pharmacology 20061228
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Serotonergic modulation of murine fundic tone. American journal of physiology. Gastrointestinal and liver physiology 20061201
Epidemiologic and clinical updates on impulse control disorders: a critical review. European archives of psychiatry and clinical neuroscience 20061201
Effects of St. John's wort extract and single constituents on stress-induced hyperthermia in mice. Planta medica 20061201
Strategies for managing antidepressant-induced sexual dysfunction: a review. Current psychiatry reports 20061201
Use of a serotonin 1A receptor agonist to treat restless legs syndrome. Journal of clinical psychopharmacology 20061201
Effects of repeated green tea catechin administration on human cytochrome P450 activity. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20061201
The Effect of Paroxetine on the Reduction of Migraine Frequency is Independent of Its Anxiolytic Effect. Journal of clinical neurology (Seoul, Korea) 20061201
Anxiolytic effects of the aqueous extract of Uncaria rhynchophylla. Journal of ethnopharmacology 20061124
Involvement of 5-hydroxytryptamine1A receptors in Delta9-tetrahydrocannabinol-induced catalepsy-like immobilization in mice. European journal of pharmacology 20061121
Effects of genetic background and null mutation of 5-HT1A receptors on basal and stress-induced body temperature: modulation by serotonergic and GABAA-ergic drugs. European journal of pharmacology 20061121
Modeling anxiety-like states: pharmacological characterization of the chick separation stress paradigm. Behavioural pharmacology 20061101
Pharmacokinetics of a newly identified active metabolite of buspirone after administration of buspirone over its therapeutic dose range. Journal of clinical pharmacology 20061101
An increased hypothermic response to buspirone in patients with major depression. Psychopharmacology 20061001
Anxiolytic-like actions of buspirone in a runway model of intravenous cocaine self-administration. Pharmacology, biochemistry, and behavior 20061001
5-HT-1A receptor responsiveness following subchronic administration of buspirone. Pakistan journal of pharmaceutical sciences 20061001
Lemon oil vapor causes an anti-stress effect via modulating the 5-HT and DA activities in mice. Behavioural brain research 20060925
Rapid desensitization of somatodendritic 5-HT1A receptors by chronic administration of the high-efficacy 5-HT1A agonist, F13714: a microdialysis study in the rat. British journal of pharmacology 20060901
Experimental animal models for the simulation of depression and anxiety. Dialogues in clinical neuroscience 20060901
Palliative management of refractory dyspnea in COPD. International journal of chronic obstructive pulmonary disease 20060901
Depression in COPD--management and quality of life considerations. International journal of chronic obstructive pulmonary disease 20060901
Effect of buspirone: An anxiolytic drug on blood glucose in humans. Indian journal of clinical biochemistry : IJCB 20060901
Thermal effects of whole head submersion in cold water on nonshivering humans. Journal of applied physiology (Bethesda, Md. : 1985) 20060801
Antidepressant-induced bruxism: need for buspirone? The international journal of neuropsychopharmacology 20060801
A trial of therapeutic hypothermia via endovascular approach in awake patients with acute ischemic stroke: methodology. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 20060801
After the failure of citalopram for depression, what next? Expert opinion on pharmacotherapy 20060801
Pharmacological interventions for benzodiazepine mono-dependence management in outpatient settings. The Cochrane database of systematic reviews 20060719
Azapirones for generalized anxiety disorder. The Cochrane database of systematic reviews 20060719
In vitro and in vivo characterization of F-97013-GD, a partial 5-HT1A agonist with antipsychotic- and antiparkinsonian-like properties. Neuropharmacology 20060701
Do antidepressants cure or create abnormal brain states? PLoS medicine 20060701
Therapeutic options: Addressing the current dilemma. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20060701
Reduction in repeated ethanol-withdrawal-induced anxiety-like behavior by site-selective injections of 5-HT1A and 5-HT2C ligands. Psychopharmacology 20060701
A comparison of mirtazapine and nortriptyline following two consecutive failed medication treatments for depressed outpatients: a STAR*D report. The American journal of psychiatry 20060701
Neuropharmacological effects of an ethanol extract of the Magnolia dealbata Zucc. leaves in mice. Journal of ethnopharmacology 20060630
Depression--augmentation or switch after initial SSRI treatment. The New England journal of medicine 20060615
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression. Journal of medicinal chemistry 20060601
Treatment of Alzheimer's disease across the spectrum of severity. Clinical interventions in aging 20060601
Dose-dependent rapid-onset akathisia with aripiprazole in patients with schizoaffective disorder. Neuropsychiatric disease and treatment 20060601
Enantioselective alpha-hydroxylation of 2-arylacetic acid derivatives and buspirone catalyzed by engineered cytochrome P450 BM-3. Journal of the American Chemical Society 20060510
Pharmacokinetics of buspirone in autistic children. Journal of clinical pharmacology 20060501
Solid-state characterization of buspirone hydrochloride polymorphs. Pharmaceutical research 20060501
TDIQ (5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline) exhibits anxiolytic-like activity in a marble-burying assay in mice. Pharmacology, biochemistry, and behavior 20060501
Drug therapy for obstructive sleep apnoea in adults. The Cochrane database of systematic reviews 20060419
Estrogen prevents 5-HT1A receptor-induced disruptions of prepulse inhibition in healthy women. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20060401
Inhibition of hepatobiliary transport as a predictive method for clinical hepatotoxicity of nefazodone. Toxicological sciences : an official journal of the Society of Toxicology 20060401
Mirtazapine in bupropion-induced dyskinesias: a case report. Movement disorders : official journal of the Movement Disorder Society 20060401
Selective blockade of NK2 or NK3 receptors produces anxiolytic- and antidepressant-like effects in gerbils. Pharmacology, biochemistry, and behavior 20060401
Chronic buspirone treatment normalizes regional serotonin synthesis in the olfactory bulbectomized rat brain: an autoradiographic study. Brain research bulletin 20060331
Pharmacological evaluation of the stress-induced social avoidance model of anxiety. Brain research bulletin 20060331
Potential vascular alpha1-adrenoceptor blocking properties of an array of 5-HT receptor ligands in the rat. European journal of pharmacology 20060327
Medication augmentation after the failure of SSRIs for depression. The New England journal of medicine 20060323
Decreases in nestlet shredding of mice by serotonin uptake inhibitors: comparison with marble burying. Life sciences 20060320
Clinical interventions for late-life anxious depression. Clinical interventions in aging 20060301
A neuropsychiatric review of pediatric obsessive-compulsive disorder: etiology and efficacious treatments. Neuropsychiatric disease and treatment 20060301
Anxiolytic-like activity of agomelatine and melatonin in three animal models of anxiety. Behavioural pharmacology 20060201
Automated software-guided identification of new buspirone metabolites using capillary LC coupled to ion trap and TOF mass spectrometry. Journal of mass spectrometry : JMS 20060201
[Review of neurobehavioral effects of alcohol-related neurodevelopmental disorder in an animal model]. Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence 20060201
Effect of modulation of serotonergic, cholinergic, and nitrergic pathways on murine fundic size and compliance measured by ultrasonomicrometry. American journal of physiology. Gastrointestinal and liver physiology 20060101
Immediate-early gene expression in the central nucleus of the amygdala is not specific for anxiolytic or anxiogenic drugs. Neuropharmacology 20060101
Contractile effects of 5-hydroxytryptamine and 5-carboxamidotryptamine in the equine jejunum. British journal of pharmacology 20060101
Effects of fluoxetine and buspirone on the panicolytic-like response induced by the activation of 5-HT1A and 5-HT2A receptors in the rat dorsal periaqueductal gray. Psychopharmacology 20060101
Anti-conflict effects of benzodiazepines in rhesus monkeys: relationship with therapeutic doses in humans and role of GABAA receptors. Psychopharmacology 20060101
Combined treatment with citalopram and buspirone: effects on serotonin 5-HT2A and 5-HT2C receptors in the rat brain. Pharmacopsychiatry 20060101
Hyper-anxiety in early sobriety: psychopharmacological treatment strategies. Journal of psychosocial nursing and mental health services 20060101
Behavioral effects of ketamine and toxic interactions with psychostimulants. BMC neuroscience 20060101
Rapid and highly sensitive liquid chromatography/electrospray ionization tandem mass spectrometry method for the quantitation of buspirone in human plasma: application to a pharmacokinetic study. Rapid communications in mass spectrometry : RCM 20060101
Topiramate plus citalopram in the treatment of Compulsive-Impulsive Sexual Behaviors. Clinical practice and epidemiology in mental health : CP & EMH 20060101
Buspirone for stereotypic movements in elderly with cognitive impairment. The Journal of neuropsychiatry and clinical neurosciences 20060101
[Efficacy of buspirone and fluoxetine in short-term treatment of bulimia nervosa]. Psychiatria polska 20060101
Sleep disturbances in patients with post-traumatic stress disorder: epidemiology, impact and approaches to management. CNS drugs 20060101
Pharmacological management of Huntington's disease: an evidence-based review. Current pharmaceutical design 20060101
Biology and therapy of fibromyalgia. Genetic aspects of fibromyalgia syndrome. Arthritis research & therapy 20060101
Challenging the serotonergic system in Parkinson disease patients: effects on cognition, mood, and motor performance. Clinical neuropharmacology 20060101
Buspirone for treatment of marijuana dependence: a pilot study. The American journal on addictions 20060101
[Neonatal buspirone modulates the intermale aggression in adult mice]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 20060101
The use of sleep aids among Emergency Medicine residents: a web based survey. BMC health services research 20060101
Inhibition of restraint-induced neuroendocrine and serotonergic responses by buspirone in rats. Pharmacological reports : PR 20060101
Psychiatric treatment for extremely traumatized civil war refugees from former Yugoslavia. Possibilities and limitations of integrating psychotherapy and medication. Torture : quarterly journal on rehabilitation of torture victims and prevention of torture 20060101
5-HT1A and 5-HT1B receptor agonists and aggression: a pharmacological challenge of the serotonin deficiency hypothesis. European journal of pharmacology 20051205
Buspirone attenuates conditioned fear-induced c-Fos expression in the rat hippocampus. Neuroscience letters 20051202
Pharmacological characterization of stress-induced hyperthermia in DBA/2 mice using metabotropic and ionotropic glutamate receptor ligands. Psychopharmacology 20051201
Role of sex and sex steroids in mediating pituitary-adrenal responses to acute buspirone treatment in sheep. Journal of neuroendocrinology 20051201
Motor effects of buspirone: Relationship with dopamine and serotonin in the striatum. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 20051201
Attenuation of restraint induced behavioral deficits by buspirone and propranolol in rats. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 20051201
Generalised anxiety disorder. Clinical evidence 20051201
Combination/augmentation strategies for improving the treatment of depression. Neuropsychiatric disease and treatment 20051201
Chronic imipramine treatment sensitizes 5-HT1A and 5-HT 2 A receptors in the dorsal periaqueductal gray matter: evidence from the elevated T-maze test of anxiety. Behavioural pharmacology 20051101
The use of sleep measures to compare a new 5HT1A agonist with buspirone in humans. Journal of psychopharmacology (Oxford, England) 20051101
Co-administration of fluoxetine and WAY100635 improves short-term memory function. European journal of pharmacology 20051017
The 5-HT1A receptor and the stimulus effects of LSD in the rat. Psychopharmacology 20051001
Antidepressant-induced adverse reactions in a patient with hemorrhagic stroke. The Annals of pharmacotherapy 20051001
Signaling pathways involved with serotonin1A agonist-mediated neuroprotection against ethanol-induced apoptosis of fetal rhombencephalic neurons. Brain research. Developmental brain research 20050908
Prior multiple ethanol withdrawals enhance stress-induced anxiety-like behavior: inhibition by CRF1- and benzodiazepine-receptor antagonists and a 5-HT1a-receptor agonist. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20050901
Analysis of low level radioactive metabolites in biological fluids using high-performance liquid chromatography with microplate scintillation counting: method validation and application. Journal of pharmaceutical and biomedical analysis 20050901
Buspirone in Rett syndrome respiratory dysfunction. Brain & development 20050901
Discriminative stimulus effects of gamma-hydroxybutyrate (GHB) and its metabolic precursor, gamma-butyrolactone (GBL) in rats. Psychopharmacology 20050901
Efficacy of the 5-HT1A agonist, buspirone hydrochloride, in migraineurs with anxiety: a randomized, prospective, parallel group, double-blind, placebo-controlled study. Headache 20050901
Patent issues in drug development: perspectives of a pharmaceutical scientist-attorney. The AAPS journal 20050901
Use of buspirone and enrichment to manage aberrant behavior in an American badger (Taxidea taxus). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20050901
Updated overview of the putative role of the serotoninergic system in obsessive-compulsive disorder. Neuropsychiatric disease and treatment 20050901
Pharmacologic treatment options for hypoactive sexual desire disorder. Women's health (London, England) 20050901
Differential distribution of functional alph}1-adrenergic receptor subtypes along the rat tail artery. The Journal of pharmacology and experimental therapeutics 20050801
Hybrid triple quadrupole-linear ion trap mass spectrometry in fragmentation mechanism studies: application to structure elucidation of buspirone and one of its metabolites. Journal of mass spectrometry : JMS 20050801
Postnatal treatment with NAN-190 but not with 5-HT1A receptor agonists retards growth of the rat brain. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20050801
In vitro profile of the antidepressant candidate OPC-14523 at rat and human 5-HT1A receptors. European journal of pharmacology 20050711
Influence of inflammatory nociception on the anxiolytic-like effect of diazepam and buspirone in rats. Psychopharmacology 20050701
Pharmacological validation of a mouse model of l-DOPA-induced dyskinesia. Experimental neurology 20050701
The place of partial agonism in psychiatry: recent developments. Journal of psychopharmacology (Oxford, England) 20050701
Analgesic therapy in postherpetic neuralgia: a quantitative systematic review. PLoS medicine 20050701
Involvement of central serotonergic systems in dextromethorphan-induced behavioural syndrome in rats. Indian journal of experimental biology 20050701
New piperidinyl- and 1,2,3,6-tetrahydropyridinyl-pyrimidine derivatives as selective 5-HT1A receptor agonists with highly potent anti-ischemic effects. Bioorganic & medicinal chemistry letters 20050615
Evidence-based pharmacotherapy of Generalized Anxiety Disorder. The international journal of neuropsychopharmacology 20050601
Efficacy of buspirone in the treatment of opioid withdrawal. Journal of clinical psychopharmacology 20050601
Anxiolytic suppression of repetitive transcranial magnetic stimulation-induced anxiety in the rats. Progress in neuro-psychopharmacology & biological psychiatry 20050601
Prediction of genotoxicity of chemical compounds by statistical learning methods. Chemical research in toxicology 20050601
The neuropsychiatry of Parkinson's disease. Minerva medica 20050601
Temperament and character inventory and pharmacotherapeutic outcome in bulimia nervosa. Eating and weight disorders : EWD 20050601
Effects of midazolam on the expression of conditioned taste aversion in rats. Brain research 20050510
Respiratory abnormalities resulting from midcervical spinal cord injury and their reversal by serotonin 1A agonists in conscious rats. The Journal of neuroscience : the official journal of the Society for Neuroscience 20050504
Trazodone and its active metabolite m-chlorophenylpiperazine as partial agonists at 5-HT1A receptors assessed by [35S]GTPgammaS binding. Journal of psychopharmacology (Oxford, England) 20050501
Pharmacological modulation of repeated ethanol withdrawal-induced anxiety-like behavior differs in alcohol-preferring P and Sprague-Dawley rats. Pharmacology, biochemistry, and behavior 20050501
Isobolographic analysis of the sedative interaction between six central nervous system depressant drugs and Valeriana edulis hydroalcoholic extract in mice. The Journal of pharmacy and pharmacology 20050501
Oral buspirone causes a shift in the dose-response curve between the elevated-plus maze and Vogel conflict tests in Long-Evans rats: relation of brain levels of buspirone and 1-PP to anxiolytic action. Methods and findings in experimental and clinical pharmacology 20050501
Cytochrome P450 3A-mediated metabolism of buspirone in human liver microsomes. Drug metabolism and disposition: the biological fate of chemicals 20050401
Evidence for a spinal serotonergic control of the peripheral inflammation in the rat. Life sciences 20050401
Altered neuroendocrine response and gastric dysmotility in the Flinders Sensitive Line rat. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20050401
Inhibitory effects of the 5-HT(1A) receptor agonist buspirone on stress-induced hyperglycemia in mice: involvement of insulin and a buspirone metabolite, 1-(2-pyrimidinyl)piperazine (1-PP). Biological & pharmaceutical bulletin 20050401
The naturally occurring Arg219Leu variant of the human 5-HT1A receptor: impairment of signal transduction. Pharmacogenetics and genomics 20050401
Effect of lactic acid and iontophoresis on drug permeation across rabbit ear skin. International journal of pharmaceutics 20050323
Antihypertensive effect of 5-HT1A agonist buspirone and 5-HT2B antagonists in experimentally induced hypertension in rats. Pharmacology 20050301
Serotonergic modulation of carbachol-induced rhythmic activity in hippocampal slices. Neuropharmacology 20050301
Cyp2D6 catalyzes 5-hydroxylation of 1-(2-pyrimidinyl)-piperazine, an active metabolite of several psychoactive drugs, in human liver microsomes. Drug metabolism and disposition: the biological fate of chemicals 20050201
Bioactivation of the nontricyclic antidepressant nefazodone to a reactive quinone-imine species in human liver microsomes and recombinant cytochrome P450 3A4. Drug metabolism and disposition: the biological fate of chemicals 20050201
The effects of fluoxetine and buspirone on self-injurious and stereotypic behavior in adult male rhesus macaques. Comparative medicine 20050201
Effect of the postsynaptic 5-HT1A receptor antagonist MM-77 on stressed mice treated with 5-HT1A receptor agents. European journal of pharmacology 20050131
Involvement of serotonin1A receptors in cardiovascular responses to stress: a radio-telemetry study in four rat strains. European journal of pharmacology 20050110
Duloxetine in the treatment of Major Depressive Disorder: a comparison of efficacy in patients with and without melancholic features. BMC psychiatry 20050101
Incidence of sexual side effects in refractory depression during treatment with citalopram or paroxetine. The Journal of clinical psychiatry 20050101
Substance use disorder comorbidity in major depressive disorder: an exploratory analysis of the Sequenced Treatment Alternatives to Relieve Depression cohort. Comprehensive psychiatry 20050101
Generalised anxiety disorder in elderly patients : epidemiology, diagnosis and treatment options. Drugs & aging 20050101
Buccal permeation of buspirone: mechanistic studies on transport pathways. Journal of pharmaceutical sciences 20050101
Tardive dyskinesia predicts prolactin response to buspirone challenge in people with schizophrenia. The Journal of neuropsychiatry and clinical neurosciences 20050101
Treatment of cerebellar ataxia with 5-HT1A agonist. Cerebellum (London, England) 20050101
Switching patients from olanzapine or risperidone to a combination treatment using perphenazine plus buspirone: evaluation of antipsychotic efficacy and side-effects, including extrapyramidal effects and weight loss. Nordic journal of psychiatry 20050101
The role of buspirone for the treatment of cerebellar ataxia in an older individual. The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique 20050101
Potentiation strategies for treatment-resistant depression. Acta psychiatrica Scandinavica. Supplementum 20050101
Efficient single nucleotide polymorphism discovery in laboratory rat strains using wild rat-derived SNP candidates. BMC genomics 20050101
Primary care use of antipsychotic drugs: an audit and intervention study. Annals of general psychiatry 20050101
Comorbid anxiety and depression. The Journal of clinical psychiatry 20050101
Treatment of agitation following traumatic brain injury: a review of the literature. NeuroRehabilitation 20050101
Interactions between corticotropin-releasing hormone and serotonin: implications for the aetiology and treatment of anxiety disorders. Handbook of experimental pharmacology 20050101
Intravascular Cooling in the Treatment of Stroke (ICTuS): early clinical experience. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 20050101
Convulsions in the treatment of obsessive-compulsive disorder. Indian journal of psychiatry 20050101
Obsessive-compulsive disorder: An interface with possible psychotic features. Indian journal of psychiatry 20050101
Buspirone to improve compliance in venlafaxine-induced movement disorder. The international journal of neuropsychopharmacology 20041201
Effect of anxiolytic, antidepressant, and antipsychotic drugs on cocaine-induced seizures and mortality. Epilepsy & behavior : E&B 20041201
Somatodendritic and postsynaptic serotonin-1A receptors in the attenuation of haloperidol-induced catalepsy. Progress in neuro-psychopharmacology & biological psychiatry 20041201
Generalised anxiety disorder. Clinical evidence 20041201
Rapid high-performance liquid chromatographic measurement of buspirone in human plasma after overdose. Biomedical chromatography : BMC 20041101
Therapeutic alternatives for difficult-to-treat depression: a narrative review of the state of the evidence. CNS spectrums 20041101
Interactions between anxiety, social support, health status and buspirone efficacy in elderly patients. Progress in neuro-psychopharmacology & biological psychiatry 20041101
Anxiolytic-like effects of extracts from Albizzia julibrissin bark in the elevated plus-maze in rats. Life sciences 20041022
Magnesium sulfate increases the rate of hypothermia via surface cooling and improves comfort. Stroke 20041001
Anxiolytic effect of berberine on exploratory activity of the mouse in two experimental anxiety models: interaction with drugs acting at 5-HT receptors. Life sciences 20041001
Psychosocial conditions and the efficacy of clinically available anxiolytics. Current drug targets 20041001
Cloned human 5-HT1A receptor pharmacology determined using agonist binding and measurement of cAMP accumulation. The Journal of pharmacy and pharmacology 20041001
Effects of injection of serotonin into nucleus caudatus on food and water intake and body weight in albino rats. Indian journal of physiology and pharmacology 20041001
Simple high-performance liquid chromatographic determination of buspirone in human plasma. Farmaco (Societa chimica italiana : 1989) 20040901
Paroxetine in the treatment of generalised anxiety disorder. Expert opinion on pharmacotherapy 20040801
Cooling for Acute Ischemic Brain Damage (COOL AID): a feasibility trial of endovascular cooling. Neurology 20040727
Social instability in female rats: effects on anxiety and buspirone efficacy. Psychopharmacology 20040701
The serotonin-1A agonist ipsapirone prevents ethanol-associated death of total rhombencephalic neurons and prevents the reduction of fetal serotonin neurons. Brain research. Developmental brain research 20040621
Effect of the 5HT1A receptor partial agonist buspirone on colorectal distension-induced pseudoaffective and behavioral responses in the female Wistar rat. European journal of pharmacology 20040621
Exposure to an elevated platform increases plasma corticosterone and hippocampal acetylcholine in the rat: reversal by chlordiazepoxide. European journal of pharmacology 20040616
Intrinsic activity and comparative molecular dynamics of buspirone analogues at the 5-HT(1A) receptors. Biochemical pharmacology 20040615
Buspirone raises blood pressure through activation of sympathetic nervous system and by direct activation of alpha1-adrenergic receptors after severe hemorrhage. The Journal of pharmacology and experimental therapeutics 20040601
Impaired action of anxiolytic drugs in mice deficient in cannabinoid CB1 receptors. Neuropharmacology 20040601
Buspirone challenge is not a valid probe of central 5-HT1A receptor function. Cephalalgia : an international journal of headache 20040601
Prediction of the affinity of the newly synthesised azapirone derivatives for 5-HT1A receptors based on artificial neural network analysis of chromatographic retention data and calculation chemistry parameters. Combinatorial chemistry & high throughput screening 20040601
Genotype-dependent changes in pain thresholds in adult mice after neonatal treatment. Bulletin of experimental biology and medicine 20040601
Generalised anxiety disorder. Clinical evidence 20040601
Cellular consequences of stress and depression. Dialogues in clinical neuroscience 20040601
Effect of environmental enrichment on stress related systems in rats. Journal of neuroendocrinology 20040501
[Combination of serotonergic agents resulted in severe adverse effects]. Lakartidningen 20040429
The design and preparation of metabolically protected new arylpiperazine 5-HT1A ligands. Bioorganic & medicinal chemistry letters 20040405
Effects of acute and chronic buspirone on impulsive choice and efflux of 5-HT and dopamine in hippocampus, nucleus accumbens and prefrontal cortex. Psychopharmacology 20040401
The photocatalytic process as a tool to identify metabolitic products formed from dopant substances: the case of buspirone. Journal of pharmaceutical and biomedical analysis 20040401
Development and validation of a high-performance liquid chromatographic method for the determination of buspirone in pharmaceutical preparations. Journal of pharmaceutical and biomedical analysis 20040401
Receptor mechanisms involved in the anticonvulsant effect of melatonin in maximal electroshock seizures. Methods and findings in experimental and clinical pharmacology 20040401
Drug interactions with St. John's Wort (Hypericum perforatum): a review of the clinical evidence. International journal of clinical pharmacology and therapeutics 20040301
Use of physicochemical calculation of pKa and CLogP to predict phospholipidosis-inducing potential: a case study with structurally related piperazines. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20040301
Current perspectives in the management of treatment-resistant depression. Dialogues in clinical neuroscience 20040301
New imide 5-HT1A receptor ligands - modification of terminal fragment geometry. Molecules (Basel, Switzerland) 20040227
Adsorptive stripping voltammetric behaviour of azomethine group in pyrimidine-containing drugs. Journal of pharmaceutical and biomedical analysis 20040218
A rapid punishment procedure for detection of anxiolytic compounds in mice. Psychopharmacology 20040201
Subtype-selective GABAergic drugs facilitate extinction of mouse operant behaviour. Neuropharmacology 20040201
The chick separation stress paradigm: a validation study. Pharmacology, biochemistry, and behavior 20040201
Pharmacology of polymorphic variants of the human 5-HT1A receptor. Biochemical pharmacology 20040201
Sequenced treatment alternatives to relieve depression (STAR*D): rationale and design. Controlled clinical trials 20040201
Myocardial perfusion scintigraphy: the evidence. European journal of nuclear medicine and molecular imaging 20040201
Changes in fatalities due to overdose of anxiolytic and sedative drugs in the UK (1983-1999). Drug safety 20040101
Systemic absorption of amitriptyline and buspirone after oral and transdermal administration to healthy cats. Journal of veterinary internal medicine 20040101
A randomized, placebo-controlled trial of buspirone for the treatment of anxiety in opioid-dependent individuals. The American journal on addictions 20040101
SSRIs versus non-SSRIs in post-traumatic stress disorder: an update with recommendations. Drugs 20040101
Effects of buspirone and alprazolam treatment on the startle-potentiated startle response. Depression and anxiety 20040101
Luteal phase administration of agents for the treatment of premenstrual dysphoric disorder. CNS drugs 20040101
Pharmacotherapy of alcohol dependence: a review of the clinical data. CNS drugs 20040101
Cortisol response to buspirone in extended abstinent alcoholics. Alcohol and alcoholism (Oxford, Oxfordshire) 20040101
Pharmacological treatments of cerebellar ataxia. Cerebellum (London, England) 20040101
5-HT1A and beta-adrenergic receptors regulate proliferation of rat blood lymphocytes. Neuroimmunomodulation 20040101
Neonatal administration of buspiron causes changes in intermale aggression of adult mice. Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 20040101
1-(2-pyrimidinyl)-piperazine, a buspirone metabolite, modulates bladder function in the anesthetized rat. Neurourology and urodynamics 20040101
Selecting pharmacotherapy for generalized anxiety disorder. The Journal of clinical psychiatry 20040101
Individual differences in the effects of serotonergic anxiolytic drugs on the motivation to self-administer cocaine. Neuroscience 20040101
Induced depressive behavior impairs learning and memory in rats. Neuroscience 20040101
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[Neurobiology and pharmacotherapy of social phobia]. L'Encephale 20040101
Role of the serotonergic system in the neurobiology of alcoholism: implications for treatment. CNS drugs 20040101
Pharmacotherapy of pervasive developmental disorders in children and adolescents. CNS drugs 20040101
[Effect of typical and atypical anxiolytics on the behavior and electrophysiological parameters of rats with model cerebrovascular pathology]. Eksperimental'naia i klinicheskaia farmakologiia 20040101
Physiology and clinical relevance of induced hypothermia. Neurocritical care 20040101
Antipanic-like effect of serotonin reuptake inhibitors in the elevated T-maze. Behavioural brain research 20031217
Effect of the novel anxiolytic drug deramciclane on the pharmacokinetics and pharmacodynamics of the CYP3A4 probe drug buspirone. European journal of clinical pharmacology 20031201
Sensitization of adenylate cyclase by short-term activation of 5-HT1A receptors. Cellular signalling 20031201
The serotonergic system may be involved in the sleep-inducing action of oleamide in rats. Naunyn-Schmiedeberg's archives of pharmacology 20031201
Sexual dysfunction with psychotropic drugs. Expert opinion on pharmacotherapy 20031201
The effect of social factors on the anxiolytic efficacy of buspirone in male rats, male mice, and men. Progress in neuro-psychopharmacology & biological psychiatry 20031201
Effects of the serotonergic anxiolytic buspirone on plasma glucose and glucose-induced hyperglycemia in mice. Journal of pharmacological sciences 20031201
Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome p450 3A4 substrate, in patients with chronic myeloid leukaemia. British journal of cancer 20031117
Anxiolytic effects of the novel anti-epileptic drug levetiracetam in the elevated plus-maze test in the rat. European journal of pharmacology 20031114
Ca2+ responses in Chinese hamster ovary-K1 cells demonstrate an atypical pattern of ligand-induced 5-HT1A receptor activation. The Journal of pharmacology and experimental therapeutics 20031101
Buspirone for anxiety and agitation in dementia. Journal of psychiatry & neuroscience : JPN 20031101
Enhanced iontophoretic delivery of buspirone hydrochloride across human skin using chemical enhancers. International journal of pharmaceutics 20031002
Harm avoidance, anxiety, and response to novelty in the adolescent S-100beta transgenic mouse: role of serotonin and relevance to Down syndrome. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20031001
Imipramine and buspirone in patients with panic disorder who are discontinuing long-term benzodiazepine therapy. Journal of clinical psychopharmacology 20031001
Buspirone treatment for apneustic breathing in brain stem infarct. Respiratory care 20031001
Anxiety disorders in the child and teen. Pediatric clinics of North America 20031001
Paroxetine: new indication. In generalised anxiety: uncertain efficacy. Prescrire international 20031001
Effect of anxiolytic drugs on air-puff-elicited ultrasonic vocalization in adult rats. Experimental animals 20031001
Buspirone differentially modifies short-term memory function in a combined delayed matching/non-matching to position task. European journal of pharmacology 20030923
Comparison of hippocampal G protein activation by 5-HT(1A) receptor agonists and the atypical antipsychotics clozapine and S16924. Naunyn-Schmiedeberg's archives of pharmacology 20030901
Faster response in depressive patients treated with fluoxetine alone than in combination with buspirone. Journal of affective disorders 20030901
The safety of SSRIs in generalised anxiety disorder: any reason to be anxious? Expert opinion on drug safety 20030901
Validation of a simple, ethologically relevant paradigm for assessing anxiety in mice. Biological psychiatry 20030901
Pharmacokinetic evaluation of gepirone immediate-release capsules and gepirone extended-release tablets in healthy volunteers. Journal of pharmaceutical sciences 20030901
Stress, social avoidance and anxiolytics: a potential model of stress-induced anxiety. Behavioural pharmacology 20030901
Effects of highly or relatively selective 5-HT1A receptor agonists on lordosis in female rats. Zoological science 20030901
Chemical stimulants of leaf-trenching by cabbage loopers: natural products, neurotransmitters, insecticides, and drugs. Journal of chemical ecology 20030901
The role of serotonergic agents as treatments for alcoholism. Drugs of today (Barcelona, Spain : 1998) 20030901
Obsessive-compulsive spectrum disorders. Dialogues in clinical neuroscience 20030901
Medication dependence and anxiety. Dialogues in clinical neuroscience 20030901
Sleep and anxiety disorders. Dialogues in clinical neuroscience 20030901
Modulation of 5-HT(1A) receptor-mediated Ca(2+) responses by co-expression with various recombinant G(alpha) proteins in CHO-K1 cells. Naunyn-Schmiedeberg's archives of pharmacology 20030801
Methylphenidate-induced obsessive-compulsive symptoms in an elderly man. CNS spectrums 20030801
An open trial of buspirone in the treatment of attention-deficit disorder. Human psychopharmacology 20030801
A quantitative method for assessing of the affective component of the pain: conditioned response associated with CO2 laser-induced nocifensive reaction. Brain research. Brain research protocols 20030801
WCA recommendations for the long-term treatment of generalized anxiety disorder. CNS spectrums 20030801
The phenomenon of one-trial tolerance to the anxiolytic effect of chlordiazepoxide in the elevated plus-maze test is abolished by previous administration of chlordiazepoxide or buspirone. Life sciences 20030711
R-citalopram counteracts the effect of escitalopram in a rat conditioned fear stress model of anxiety. Pharmacology, biochemistry, and behavior 20030701
Effects of autoshaping procedures on 3H-8-OH-DPAT-labeled 5-HT1a binding and 125I-LSD-labeled 5-HT2a binding in rat brain. Brain research 20030613
A 5-HT1A agonist and a 5-HT2c antagonist reduce social interaction deficit induced by multiple ethanol withdrawals in rats. Psychopharmacology 20030601
Responses to exercise in the heat related to measures of hypothalamic serotonergic and dopaminergic function. European journal of applied physiology 20030601
Mutation in a protein kinase C phosphorylation site of the 5-HT1A receptor preferentially attenuates Ca2+ responses to partial as opposed to higher-efficacy 5-HT1A agonists. Neuropharmacology 20030601
Involvement of 5-HT1A receptors in animal tests of anxiety and depression: evidence from genetic models. Stress (Amsterdam, Netherlands) 20030601
Altered dopamine D2 receptor function in fibromyalgia patients: a neuroendocrine study with buspirone in women with fibromyalgia compared to female population based controls. Journal of affective disorders 20030601
Iontophoretic transdermal delivery of buspirone hydrochloride in hairless mouse skin. AAPS pharmSci 20030601
Generalised anxiety disorder. Clinical evidence 20030601
Serotonin 1A receptor agonists reverse respiratory abnormalities in spinal cord-injured rats. The Journal of neuroscience : the official journal of the Society for Neuroscience 20030515
8-[3H]-hydroxy-2-(di-n-propylamino)tetralin binding sites in blood lymphocytes of rats and the modulation by mitogens and immobilization. Journal of neuroimmunology 20030501
Residual symptoms in depression: can treatment be symptom-specific? The Journal of clinical psychiatry 20030501
[Circannual rhythm of drug use by a psychiatric clinic]. Psychiatrische Praxis 20030501
Effects of venlafaxine, buspirone, and placebo on colonic sensorimotor functions in healthy humans. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20030501
22-kHz ultrasonic vocalization in rats as an index of anxiety but not fear: behavioral and pharmacological modulation of affective state. Behavioural brain research 20030417
The anxiolytic CRF(1) antagonist DMP696 fails to function as a discriminative stimulus and does not substitute for chlordiazepoxide in rats. Psychopharmacology 20030401
GABA-A and 5-HT1A receptor agonists block expression of fear-potentiated startle in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030401
Metabotropic glutamate receptor 5 antagonist-induced stimulation of hypothalamic-pituitary-adrenal axis activity: interaction with serotonergic systems. Neuropharmacology 20030401
Effects of ethanol and ipsapirone on the development of midline raphe glial cells and astrocytes. Alcohol (Fayetteville, N.Y.) 20030401
Cocaine- and amphetamine-regulated transcript peptide produces anxiety-like behavior in rodents. European journal of pharmacology 20030307
Buspirone-induced antinociception is mediated by L-type calcium channels and calcium/caffeine-sensitive pools in mice. Psychopharmacology 20030301
Assessment of the contributions of CYP3A4 and CYP3A5 in the metabolism of the antipsychotic agent haloperidol to its potentially neurotoxic pyridinium metabolite and effect of antidepressants on the bioactivation pathway. Drug metabolism and disposition: the biological fate of chemicals 20030301
EEG effects of buspirone and pindolol: a method of examining 5-HT1A receptor function in humans. Psychopharmacology 20030301
Human cytochromes mediating gepirone biotransformation at low substrate concentrations. Biopharmaceutics & drug disposition 20030301
Behavioral disturbances in dementia. Dialogues in clinical neuroscience 20030301
Effects of antidepressants on the exploration, spontaneous motor activity and isolation-induced aggressiveness in mice. Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20030218
Effects of chronic treatment with ipsapirone and buspirone on the C57BL/6J strain mice under social stress. Life sciences 20030214
Development and validation of an in vitro-in vivo correlation for buspirone hydrochloride extended release tablets. Journal of controlled release : official journal of the Controlled Release Society 20030214
Central 5-HT receptor hypersensitivity in migraine without aura. Cephalalgia : an international journal of headache 20030201
5-HT1A receptor activity disrupts spontaneous alternation behavior in rats. Pharmacology, biochemistry, and behavior 20030201
Venlafaxine-induced galactorrhea. Journal of clinical psychopharmacology 20030201
Pseudo-Parkinson disease secondary to ritonavir-buspirone interaction. The Annals of pharmacotherapy 20030201
Is there a role for 5-HT1A agonists in the treatment of depression? Biological psychiatry 20030201
Effect of the serotonin agonist buspirone on behaviour and hypothalamic-pituitary-adrenal axis in confident and fearful mink. Physiology & behavior 20030201
The antidepressant-like effects of neurokinin NK1 receptor antagonists in a gerbil tail suspension test. Behavioural pharmacology 20030201
Differing central amine receptor sensitivity in different migraine subtypes? A neuroendocrine study using buspirone. Pain 20030201
N-in-one permeability studies of heterogeneous sets of compounds across Caco-2 cell monolayers. Pharmaceutical research 20030201
[Pharmacological treatment of post-traumatic behavioural disorders]. Annales de readaptation et de medecine physique : revue scientifique de la Societe francaise de reeducation fonctionnelle de readaptation et de medecine physique 20030201
Development of a presynaptic 5-HT1A antagonist. Bioorganic & medicinal chemistry letters 20030120
In vivo comparison of two 5-HT1A receptors agonists alnespirone (S-20499) and buspirone on locus coeruleus neuronal activity. European journal of pharmacology 20030110
Buspirone decreases physiological reactivity to unconditioned and conditioned aversive stimuli. Psychopharmacology 20030101
Effects of cholecystokinin tetrapeptide (CCK(4)) and of anxiolytic drugs on GABA outflow from the cerebral cortex of freely moving rats. Neurochemistry international 20030101
Selective effects of serotonergic psychoactive agents on gastrointestinal functions in health. American journal of physiology. Gastrointestinal and liver physiology 20030101
Discriminative stimulus effects of positive GABAA modulators and other anxiolytics, sedatives, and anticonvulsants in untreated and diazepam-treated monkeys. The Journal of pharmacology and experimental therapeutics 20030101
Treating generalized anxiety disorder. The Journal of clinical psychiatry 20030101
Alcohol and psychiatric comorbidity. Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism 20030101
Update on the role of drug therapy in non-ulcer dyspepsia. Reviews in gastroenterological disorders 20030101
Anxiolytic effect of ting-chih-wan in mouse behavior models of anxiety. The American journal of Chinese medicine 20030101
Kava-Kava extract LI 150 is as effective as Opipramol and Buspirone in Generalised Anxiety Disorder--an 8-week randomized, double-blind multi-centre clinical trial in 129 out-patients. Phytomedicine : international journal of phytotherapy and phytopharmacology 20030101
Effects of buspirone in withdrawal from opiates. The American journal on addictions 20030101
Effects of acute tryptophan depletion on executive function in healthy male volunteers. BMC psychiatry 20030101
Mirtazapine in L-dopa-induced dyskinesias. Clinical neuropharmacology 20030101
Pharmacotherapy of social phobia. Acta psychiatrica Scandinavica. Supplementum 20030101
Electrospray mass spectrometric studies of noncovalent complexes of buspirone hydrochloride and other serotonin 5-HT(1A) receptor ligands containing arylpiperazine moieties. Rapid communications in mass spectrometry : RCM 20030101
[Effect of buspirone on aggressive and anxiety behavior of male mice with various aggressive experience]. Eksperimental'naia i klinicheskaia farmakologiia 20030101
What is a significant response in drug studies of attention-deficit/hyperactivity disorder: statistical significance is necessary, but is it sufficient? Psychopharmacology bulletin 20030101
Anxiety and chronic obstructive pulmonary disease: prevalence, impact, and treatment. Psychosomatic medicine 20030101
Serotonin agonists and antagonists in obstructive sleep apnea: therapeutic potential. American journal of respiratory medicine : drugs, devices, and other interventions 20030101
Buspirone in Alzheimer's disease. Expert review of neurotherapeutics 20030101
Effects of ethanol and 5-HT1A agonists on astroglial S100B. Brain research. Developmental brain research 20021215
Induction of mild systemic hypothermia with endovascular cooling during primary percutaneous coronary intervention for acute myocardial infarction. Journal of the American College of Cardiology 20021204
The treatment of generalised anxiety disorder. A systematic review. Panminerva medica 20021201
Pharmacokinetic-pharmacodynamic modeling of buspirone and its metabolite 1-(2-pyrimidinyl)-piperazine in rats. The Journal of pharmacology and experimental therapeutics 20021201
Treatment of generalised anxiety disorder with a short course of psychological therapy, combined with buspirone or placebo. Journal of affective disorders 20021201
Indorenate produces antidepressant-like actions in the rat forced swimming test via 5-HT1A receptors. Psychopharmacology 20021201
Treatment functional GI disease: the complex pharmacology of serotonergic drugs. British journal of clinical pharmacology 20021201
Possible serotonin syndrome after combination of buspirone and St John's Wort. Journal of psychopharmacology (Oxford, England) 20021201
Serotonergic dysregulation in bipolar disorders: a literature review of serotonergic challenge studies. Bipolar disorders 20021201
Antidepressants reduce phosphoinositide-specific phospholipase C (PI-PLC) activity and the mRNA and protein expression of selective PLC beta 1 isozyme in rat brain. Neuropharmacology 20021201
Cocaine-induced anxiety: alleviation by diazepam, but not buspirone, dimenhydrinate or diphenhydramine. Behavioural pharmacology 20021101
Modulation of reflexly evoked vagal bradycardias by central 5-HT1A receptors in anaesthetized rabbits. British journal of pharmacology 20021101
Rigid analogues of buspirone and gepirone, 5-HT1A receptors partial agonists. Farmaco (Societa chimica italiana : 1989) 20021101
Effects of triazolam, 8-OH-DPAT, and buspirone on repeated acquisition in squirrel monkeys. Experimental and clinical psychopharmacology 20021101
5-HT1A receptor activation and anti-cataleptic effects: high-efficacy agonists maximally inhibit haloperidol-induced catalepsy. European journal of pharmacology 20021025
What to do when SSRIs fail: eight strategies for optimizing treatment of panic disorder. American family physician 20021015
5-HT1A receptor-mediated regulation of mitogen-activated protein kinase phosphorylation in rat brain. European journal of pharmacology 20021004
World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the pharmacological treatment of anxiety, obsessive-compulsive and posttraumatic stress disorders. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 20021001
Involvement of 5-HT1A and 5-HT2 receptor in cisplatin induced emesis in dogs. Indian journal of physiology and pharmacology 20021001
Developing strategies for isolation of minor impurities with mass spectrometry-directed fractionation. Journal of chromatography. A 20020913
Anxiolytic-like activity of the mGluR5 antagonist MPEP: a comparison with diazepam and buspirone. Pharmacology, biochemistry, and behavior 20020901
The gerbil elevated plus-maze I: behavioral characterization and pharmacological validation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20020901
The effects of alprazolam and buspirone in light and moderate female social drinkers. Behavioural pharmacology 20020901
Psychopharmacology of anxiety disorders. Dialogues in clinical neuroscience 20020901
Nonpharmacological treatments for anxiety disorders. Dialogues in clinical neuroscience 20020901
Serotonin 1A receptor activation and hypothermia in humans: lack of evidence for a presynaptic mediation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20020801
Prediction of hepatic clearance and availability by cryopreserved human hepatocytes: an application of serum incubation method. Drug metabolism and disposition: the biological fate of chemicals 20020801
A preliminary study of buspirone stimulated prolactin release in generalised social phobia: evidence for enhanced serotonergic responsivity? European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20020801
Effects of antidepressants in rats trained to discriminate centrally administered isoproterenol. The Journal of pharmacology and experimental therapeutics 20020801
Clinical inquiries. What are the treatment options for SSRI-related sexual dysfunction? The Journal of family practice 20020801
Postsynaptic 5-HT(1A) receptors mediate an increase in locomotor activity in the monoamine-depleted rat. Psychopharmacology 20020801
[Buspirone chlorhydrate in the treatment of cerebellar ataxia]. Revista de neurologia 20020801
[Preparation of buspirone hydrochloride buccal adhesive tablet and study on its drug release mechanism]. Yao xue xue bao = Acta pharmaceutica Sinica 20020801
Influence of forced swimming-induced stress on the anxiolytic-like effect of 5HT(1A) agents in mice. Psychopharmacology 20020701
The use of buspirone in primary care. Journal of psychosocial nursing and mental health services 20020701
Tonic immobility in guinea pigs: a behavioural response for detecting an anxiolytic-like effect? Behavioural pharmacology 20020701
Efficacy of newer antidepressants for childhood anxiety disorders. Expert review of neurotherapeutics 20020701
[Serotonin syndrome--several cases of this often overlooked diagnosis]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20020630
Withdrawal from chronic ethanol increases the sensitivity of presynaptic 5-HT(1A) receptors modulating serotonin and dopamine synthesis in rat brain in vivo. Neuroscience letters 20020628
Relief of serotonin selective reuptake inhibitor induced sexual dysfunction with low-dose mianserin in patients with traumatic brain injury. Psychopharmacology 20020601
Region-dependent effects of flibanserin and buspirone on adenylyl cyclase activity in the human brain. The international journal of neuropsychopharmacology 20020601
Treatment of depression associated with the menstrual cycle: premenstrual dysphoria, postpartum depression, and the perimenopause. Dialogues in clinical neuroscience 20020601
Imipramine but not 5-HT(1A) receptor agonists or neuroleptics induces adaptive changes in hippocampal 5-HT(1A) and 5-HT(4) receptors. European journal of pharmacology 20020517
Extended action of MKC-242, a selective 5-HT(1A) receptor agonist, on light-induced Per gene expression in the suprachiasmatic nucleus in mice. Journal of neuroscience research 20020515
Rifampin and rifabutin drug interactions: an update. Archives of internal medicine 20020513
[Serotonin syndrome. Several cases of this often overlooked diagnosis]. Lakartidningen 20020502
The pharmacological treatment of anxiety disorders in children and adolescents. Expert opinion on pharmacotherapy 20020501
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. The Journal of biological chemistry 20020419
Tandospirone potentiates the fluoxetine-induced increases in extracellular dopamine via 5-HT(1A) receptors in the rat medial frontal cortex. Neurochemistry international 20020401
Hypomania induced by herbal and pharmaceutical psychotropic medicines following mild traumatic brain injury. Brain injury 20020401
Contact leukoderma caused by buspirone patches. American journal of contact dermatitis : official journal of the American Contact Dermatitis Society 20020301
[Buspirone increases D2-like dopaminergic receptor density in rat corpus striatum]. Arquivos de neuro-psiquiatria 20020301
The role of substance P in depression: therapeutic implications. Dialogues in clinical neuroscience 20020301
Benzodiazepine discontinuation in generalized anxiety disorder. The American journal of psychiatry 20020201
Acute buspirone abolishes the expression of behavioral dopaminergic supersensitivity in mice. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20020201
Bupropion-induced acute dystonia. The Annals of pharmacotherapy 20020201
Olfactory-mediated fear-potentiated startle. Behavioral neuroscience 20020201
Pharmacological and endocrinological characterisation of stress-induced hyperthermia in singly housed mice using classical and candidate anxiolytics (LY314582, MPEP and NKP608). European journal of pharmacology 20020125
Short term aerobic exercise training in young males does not alter sensitivity to a central serotonin agonist. Experimental physiology 20020101
The stimulus effect of 5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline is similar to that of cocaine but different from that of amphetamine. Pharmacology, biochemistry, and behavior 20020101
Anxiogenic activity of Myristica fragrans seeds. Pharmacology, biochemistry, and behavior 20020101
Effect of drug proportion and mixing time on the content uniformity of a low dose drug in a high shear mixer. Die Pharmazie 20020101
Atypical kinetics for a series of putative dopamine antagonists to reverse the low-magnitude Ca2+ phase in the dopamine-bound D2short receptor state. Naunyn-Schmiedeberg's archives of pharmacology 20020101
Light-enhanced startle: further pharmacological and behavioral characterization. Psychopharmacology 20020101
Seed finding in golden hamsters: a potential animal model for screening anxiolytic drugs. Neuropsychobiology 20020101
Factors explaining variance in perceived pain in women with fibromyalgia. BMC musculoskeletal disorders 20020101
Treatment of generalized anxiety disorder. The Journal of clinical psychiatry 20020101
Drug treatments for obstructive sleep apnoea. The Cochrane database of systematic reviews 20020101
Marked suppression of gastric ulcerogenesis and intestinal responses to stress by a novel class of drugs. Molecular psychiatry 20020101
[Review of psychopharmacological treatments in adolescents and adults with autistic disorders]. L'Encephale 20020101
Generalised anxiety disorder: treatment options. Drugs 20020101
Pharmacology of flibanserin. CNS drug reviews 20020101
Glucose intolerance with atypical antipsychotics. Drug safety 20020101
Nad-299 antagonises 5-HT-stimulated and spiperone-inhibited [35S]GTPgammaS binding in cloned 5-HT1A receptors. Journal of receptor and signal transduction research 20020101
Repeated treatment with selective serotonin reuptake inhibitors but not anxiolytics prevents the stress-induced deficit of fighting behavior. Polish journal of pharmacology 20020101
Pharmacotherapy of generalized anxiety disorder. The Journal of clinical psychiatry 20020101
13C cpmas nmr and molecular modeling in the studies of new analogues of buspirone. Acta poloniae pharmaceutica 20020101
Effects of cholecystokinin tetrapeptide (CCK(4)) and anxiolytic drugs on the electrically evoked [(3)H]5-hydroxytryptamine outflow from rat cortical slices. Brain research 20011213
trans-4-[4-(Methoxyphenyl)cyclohexyl]-1-arylpiperazines: a new class of potent and selective 5-HT(1A) receptor ligands as conformationally constrained analogues of 4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]-1-arylpiperazines. Journal of medicinal chemistry 20011206
Pharmacokinetics and tolerability of buspirone during oral administration to children and adolescents with anxiety disorder and normal healthy adults. Journal of clinical pharmacology 20011201
Effect of nonnicotine pharmacotherapy on smoking behavior. Pharmacotherapy 20011201
The impact of impulsivity on cocaine use and retention in treatment. Journal of substance abuse treatment 20011201
Serotonergic regulation of inhibitory avoidance and one-way escape in the rat elevated T-maze. Neuroscience and biobehavioral reviews 20011201
Astrocyte-mediated trophic support of developing serotonin neurons: effects of ethanol, buspirone, and S100B. Brain research. Developmental brain research 20011126
Buspirone and meperidine synergistically reduce the shivering threshold. Anesthesia and analgesia 20011101
Quantifying the 5-HT1A agonist action of buspirone in man. Psychopharmacology 20011101
Acoustic startle, conditioned startle potentiation and the effects of 8-OH-DPAT and buspirone in rats selectively bred for differences in 8-OH-DPAT-induced hypothermia. Behavioural pharmacology 20011101
Pattern of symptom improvement following treatment with venlafaxine XR in patients with generalized anxiety disorder. The Journal of clinical psychiatry 20011101
Molecular dynamics of 5-HT1A and 5-HT2A serotonin receptors with methylated buspirone analogues. Journal of computer-aided molecular design 20011101
Impact of cortisol on buspirone stimulated prolactin release: a double-blind placebo-controlled study. Psychoneuroendocrinology 20011001
Small platform stress increases exploratory activity of mice in staircase test. Progress in neuro-psychopharmacology & biological psychiatry 20011001
A double-blind placebo-controlled study of buspirone-stimulated prolactin release in non-ulcer dyspepsia--are central serotoninergic responses enhanced? Alimentary pharmacology & therapeutics 20011001
The effect of glucocorticoids on the anxiolytic efficacy of buspirone. Psychopharmacology 20011001
Venlafaxine and generalised anxiety disorder: new preparation. Minimise recourse to drugs. Prescrire international 20011001
Diazepam, but not buspirone, induces similar anxiolytic-like actions in lactating and ovariectomized Wistar rats. Pharmacology, biochemistry, and behavior 20010901
Effectiveness of pharmacotherapy for body dysmorphic disorder: a chart-review study. The Journal of clinical psychiatry 20010901
An open study of buspirone augmentation of neuroleptics in patients with schizophrenia. Journal of clinical psychopharmacology 20010801
Ataxia from lithium toxicity successfully treated with high-dose buspirone: a single-case experimental design. Archives of physical medicine and rehabilitation 20010801
A comparative multidose pharmacokinetic study of buspirone extended-release tablets with a reference immediate-release product. Journal of clinical pharmacology 20010801
Review of pharmacokinetic and pharmacodynamic interaction studies with citalopram. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20010801
Switching from benzodiazepines to buspirone using a tapered overlap method in generalized anxiety disorder. The Journal of clinical psychiatry 20010801
Gepirone. Organon. Current opinion in investigational drugs (London, England : 2000) 20010801
[Permeation of buspirone hydrochloride across animal buccal mucosa and its mechanism]. Yao xue xue bao = Acta pharmaceutica Sinica 20010801
Characterization of alpha1-adrenoceptor-mediated contraction in the mouse thoracic aorta. European journal of pharmacology 20010720
Serotonin-based pharmacotherapy for acute neuroleptic-induced akathisia: a new approach to an old problem. The British journal of psychiatry : the journal of mental science 20010701
Late-onset bipolar disorder due to hyperthyroidism. Acta psychiatrica Scandinavica 20010701
Common effects of chronically administered antipanic drugs on brainstem GABA(A) receptor subunit gene expression. Molecular psychiatry 20010701
Pharmacokinetics of buspirone extended-release tablets: a single-dose study. Journal of clinical pharmacology 20010701
An open trial of divalproex sodium in autism spectrum disorders. The Journal of clinical psychiatry 20010701
Drug-induced potentiation of prepulse inhibition of acoustic startle reflex in mice: a model for detecting antipsychotic activity? Psychopharmacology 20010701
Potential involvement of S100B in the protective effects of a serotonin-1a agonist on ethanol-treated astrocytes. Brain research. Developmental brain research 20010629
SSRI discontinuation and buspirone. The American journal of psychiatry 20010601
Patients with severe depression may benefit from buspirone augmentation of selective serotonin reuptake inhibitors: results from a placebo-controlled, randomized, double-blind, placebo wash-in study. The Journal of clinical psychiatry 20010601
An investigation of the mechanisms responsible for acute fluoxetine-induced anxiogenic-like effects in mice. Behavioural pharmacology 20010601
5-HT1A receptor activation and antidepressant-like effects: F 13714 has high efficacy and marked antidepressant potential. European journal of pharmacology 20010525
Biochemical, electrophysiological and neurohormonal studies with B-20991, a selective 5-HT1A receptor agonist. Pharmacology 20010501
Quantifying drug-related 5-HT1A receptor occupancy with. Psychopharmacology 20010501
Compounds with affinity for serotonergic receptors in the treatment of premenstrual dysphoria: a comparison of buspirone, nefazodone and placebo. Psychopharmacology 20010501
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Molecular dynamics of buspirone analogues interacting with the 5-HT1A and 5-HT2A serotonin receptors. Bioorganic & medicinal chemistry 20010401
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