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3644-61-9 | Tolperisone hydrochloride
CAS No: 3644-61-9 Catalog No: AG003UU4 MDL No:MFCD00058211
Product Description
Catalog Number:
AG003UU4
Chemical Name:
Tolperisone hydrochloride
CAS Number:
3644-61-9
Molecular Formula:
C16H24ClNO
Molecular Weight:
281.8209
MDL Number:
MFCD00058211
IUPAC Name:
2-methyl-1-(4-methylphenyl)-3-piperidin-1-ylpropan-1-one;hydrochloride
InChI:
InChI=1S/C16H23NO.ClH/c1-13-6-8-15(9-7-13)16(18)14(2)12-17-10-4-3-5-11-17;/h6-9,14H,3-5,10-12H2,1-2H3;1H
InChI Key:
ZBUVYROEHQQAKL-UHFFFAOYSA-N
SMILES:
CC(C(=O)c1ccc(cc1)C)CN1CCCCC1.Cl
EC Number:
222-876-5
NSC Number:
757872
Properties
Complexity:
262
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
281.155g/mol
Formal Charge:
0
Heavy Atom Count:
19
Hydrogen Bond Acceptor Count:
2
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
281.824g/mol
Monoisotopic Mass:
281.155g/mol
Rotatable Bond Count:
4
Topological Polar Surface Area:
20.3A^2
Undefined Atom Stereocenter Count:
1
Undefined Bond Stereocenter Count:
0
Literature
| Title | Journal |
|---|---|
| Fatal tolperisone poisoning: autopsy and toxicology findings in three suicide cases. | Forensic science international 20120210 |
| A phase IV observational multi-centre, open-label study on efficacy and safety of tolperisone 150 mg in patients with painful muscle spasm associated with degenerative or inflammatory diseases of the musculoskeletal system. | The Journal of the Association of Physicians of India 20110101 |
| An immediate hypersensitivity reaction caused by tolperisone hydrochloride. | Journal of investigational allergology & clinical immunology 20110101 |
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
| [IGOST guideline for pharmacotherapy of low back pain]. | MMW Fortschritte der Medizin 20100812 |
| Tolperisone. | The Journal of the Association of Physicians of India 20100201 |
| NMR analysis, protonation equilibria and decomposition kinetics of tolperisone. | Journal of pharmaceutical and biomedical analysis 20091205 |
| [New therapies for spastic movement disorders]. | MMW Fortschritte der Medizin 20091001 |
| [Efficiency local injection therapy with preparation mydocalm in myofascial pain syndrome cervicobrachial region]. | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20090101 |
| Tolperisone: a typical representative of a class of centrally acting muscle relaxants with less sedative side effects. | CNS neuroscience & therapeutics 20080101 |
| Considerable interindividual variation in the pharmacokinetics of tolperisone HCl. | International journal of clinical pharmacology and therapeutics 20070201 |
| [Use of local injections of tolperisone (midocalm) in combination with tractional therapy in the treatment of vertebral static syndrome]. | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20070101 |
| [Post-operative pain therapy of a chronic pain patient]. | Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 20061101 |
| [Comparative effciency of bakloferon and tolperizon central muscle relaxants in complex therapy of back pain]. | Voenno-meditsinskii zhurnal 20060901 |
| A comparative study of the action of tolperisone on seven different voltage dependent sodium channel isoforms. | European journal of pharmacology 20060524 |
| HPLC determination of tolperisone in human plasma. | Archives of pharmacal research 20060401 |
| [A randomized, double blind, placebo-controlled study of the efficacy and safety of tolperisone in spasticity following cerebral stroke]. | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20060101 |
| Tolperisone-type drugs inhibit spinal reflexes via blockade of voltage-gated sodium and calcium channels. | The Journal of pharmacology and experimental therapeutics 20051201 |
| A randomized, double-blind, placebo-controlled study of the efficacy and safety of tolperisone in spasticity following cerebral stroke. | European journal of neurology 20050601 |
| Simple pharmacological test battery to assess efficacy and side effect profile of centrally acting muscle relaxant drugs. | Journal of pharmacological and toxicological methods 20050101 |
| [Midocalm in complex therapy of chronic low back pain syndrome]. | Klinicheskaia meditsina 20050101 |
| [A study of mydocalm efficiency in the treatment of chronic headache of tension]. | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20050101 |
| [Restorative treatment of degenerative-dystrophic diseases of large joints]. | Vestnik khirurgii imeni I. I. Grekova 20040101 |
| Separation of basic drug enantiomers by capillary electrophoresis using chicken alpha1-acid glycoprotein: insight into chiral recognition mechanism. | Electrophoresis 20030801 |
| Anaphylactic reactions to tolperisone (Mydocalm). | Swiss medical weekly 20030628 |
| [Back aches often become a chronic problem. Sodium channel block against chronification]. | MMW Fortschritte der Medizin 20030619 |
| Identification of metabolic pathways involved in the biotransformation of tolperisone by human microsomal enzymes. | Drug metabolism and disposition: the biological fate of chemicals 20030501 |
| [Fibromyalgia also has psychological origins. 'Often harmony seeking perfectionists']. | MMW Fortschritte der Medizin 20030501 |
| Simultaneous micellar LC determination of lidocaine and tolperisone. | Journal of pharmaceutical and biomedical analysis 20030326 |
| [To make easier everyday life of stroke patients. Muscle relaxants diminish spasms]. | MMW Fortschritte der Medizin 20030227 |
| [Spinal pain and its treatment with midocalm]. | Terapevticheskii arkhiv 20030101 |
| Prophylactic tolperisone for post-exercise muscle soreness causes reduced isometric force--a double-blind randomized crossover control study. | European journal of pain (London, England) 20030101 |
| Effect of muscle relaxants on experimental jaw-muscle pain and jaw-stretch reflexes: a double-blind and placebo-controlled trial. | European journal of pain (London, England) 20030101 |
| [Mydocalm causing anaphylaxis]. | Pneumonologia i alergologia polska 20030101 |
| [Patient with chronic backache. Disabled or muscle spasm patient?]. | MMW Fortschritte der Medizin 20021205 |
| [Muscular pain and fatigue: is fibromyalgia sticking behind? These points bring it to light]. | MMW Fortschritte der Medizin 20021031 |
| Protein domain of chicken alpha(1)-acid glycoprotein is responsible for chiral recognition. | Biochemical and biophysical research communications 20020719 |
| [Preventing chronification. So pain isn't branded into memory]. | MMW Fortschritte der Medizin 20020516 |
| [Fibromyalgia problem case. Monotherapy is mostly insufficient]. | MMW Fortschritte der Medizin 20020425 |
| [Mydeton: a centrally acting muscle relaxant drug from Gedeon Richter LTD]. | Acta pharmaceutica Hungarica 20020101 |
| Simultaneous determination of tolperisone and lidocaine by high performance liquid chromatography. | Journal of pharmaceutical and biomedical analysis 20011201 |
| Tolperisone--a novel modulator of ionic currents in myelinated axons. | General physiology and biophysics 20011201 |
| Separation of basic drug enantiomers by capillary electrophoresis using ovoglycoprotein as a chiral selector: comparison of chiral resolution ability of ovoglycoprotein and completely deglycosylated ovoglycoprotein. | Electrophoresis 20010901 |
| Method for recording spinal reflexes in mice: effects of thyrotropin-releasing hormone, DOI, tolperisone and baclofen on monosynaptic spinal reflex potentials. | Japanese journal of pharmacology 20010501 |
| [Spastic syndrome. More mobile again after stroke]. | MMW Fortschritte der Medizin 20010308 |
| Use of vancomycin silica stationary phase in packed capillary electrochromatography I. Enantiomer separation of basic compounds. | Electrophoresis 20010201 |
| [Two complex suicidal poisonings with drugs and their medicolegal aspects]. | Przeglad lekarski 20010101 |
| [Neuropharmacological studies on tolperisone hydrochloride (author's transl)]. | Nihon yakurigaku zasshi. Folia pharmacologica Japonica 19791001 |
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