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Home > Indoles and Oxindole > 3613-73-8
3613-73-8 | 1H-Pyrido[4,3-b]indole,2,3,4,5-tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-
CAS No: 3613-73-8 Catalog No: AG00I75J MDL No:MFCD00387540
Product Description
Catalog Number:
AG00I75J
Chemical Name:
1H-Pyrido[4,3-b]indole,2,3,4,5-tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-
CAS Number:
3613-73-8
Molecular Formula:
C21H25N3
Molecular Weight:
319.4433
MDL Number:
MFCD00387540
IUPAC Name:
2,8-dimethyl-5-[2-(6-methylpyridin-3-yl)ethyl]-3,4-dihydro-1H-pyrido[4,3-b]indole
InChI:
InChI=1S/C21H25N3/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17/h4-7,12-13H,8-11,14H2,1-3H3
InChI Key:
JNODQFNWMXFMEV-UHFFFAOYSA-N
SMILES:
CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(nc1)C
UNII:
OD9237K1Z6
Properties
Complexity:
425
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
319.205g/mol
Formal Charge:
0
Heavy Atom Count:
24
Hydrogen Bond Acceptor Count:
2
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
319.452g/mol
Monoisotopic Mass:
319.205g/mol
Rotatable Bond Count:
3
Topological Polar Surface Area:
21.1A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.5
Literature
| Title | Journal |
|---|---|
| Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease. | Journal of medicinal chemistry 20140911 |
| Glutamate receptor modulator dimebon stimulates consolidation and reconsolidation of weak memory in chicks. | Bulletin of experimental biology and medicine 20120901 |
| Anhedonic-like traits and lack of affective deficits in 18-month-old C57BL/6 mice: Implications for modeling elderly depression. | Experimental gerontology 20120801 |
| Dimebon slows progression of proteinopathy in γ-synuclein transgenic mice. | Neurotoxicity research 20120701 |
| Double-blind placebo-controlled randomized efficacy and safety trial of add-on treatment of dimebon plus risperidone in schizophrenic patients during transition from acute psychotic episode to remission. | Psychiatria Danubina 20120601 |
| Dimebon attenuates methamphetamine, but not MPTP, striatal dopamine depletion. | Neurochemistry international 20120601 |
| The acute effects of dimebolin, a potential Alzheimer's disease treatment, on working memory in rhesus monkeys. | British journal of pharmacology 20111001 |
| Latrepirdine increases cerebral glucose utilization in aged mice as measured by [18F]-fluorodeoxyglucose positron emission tomography. | Neuroscience 20110825 |
| Dimebon does not ameliorate pathological changes caused by expression of truncated (1-120) human alpha-synuclein in dopaminergic neurons of transgenic mice. | Neuro-degenerative diseases 20110801 |
| Drugs: a tangled web of targets. | Nature 20110713 |
| Dimebolin in dementia. | CNS neuroscience & therapeutics 20110601 |
| Ruthenium-catalyzed γ-carbolinium ion formation from aryl azides; synthesis of dimebolin. | Organic letters 20110520 |
| [Geroprotective properties of dimebon: morphological characterization of organs and tissues in mice after long-term treatment]. | Eksperimental'naia i klinicheskaia farmakologiia 20110101 |
| The rise and fall of Dimebon. | Drug news & perspectives 20101001 |
| Investigational medications for treatment of patients with Alzheimer disease. | The Journal of the American Osteopathic Association 20100901 |
| [Drug therapy for Alzheimer's disease]. | Brain and nerve = Shinkei kenkyu no shinpo 20100701 |
| Cognition-enhancing properties of Dimebon in a rat novel object recognition task are unlikely to be associated with acetylcholinesterase inhibition or N-methyl-D-aspartate receptor antagonism. | The Journal of pharmacology and experimental therapeutics 20100601 |
| From anti-allergic to anti-Alzheimer's: Molecular pharmacology of Dimebon. | Current Alzheimer research 20100301 |
| 8-Sulfonyl-substituted tetrahydro-1H-pyrido[4,3-b]indoles as 5-HT6 receptor antagonists. | European journal of medicinal chemistry 20100201 |
| Synthesis and biological activity of 5-styryl and 5-phenethyl-substituted 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles. | Bioorganic & medicinal chemistry letters 20100101 |
| Dimebon (latrepirdine) enhances mitochondrial function and protects neuronal cells from death. | Journal of Alzheimer's disease : JAD 20100101 |
| Synthesis and biological evaluation of novel 5,8-disubstituted-2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b] indoles as 5-HT(6) and H(1) receptors antagonists. | Archiv der Pharmazie 20091201 |
| Dimebolin is a 5-HT6 antagonist with acute cognition enhancing activities. | Biochemical pharmacology 20091015 |
| Dimebon as a potential therapy for Alzheimer's disease. | CNS spectrums 20090801 |
| Synthesis and biological evaluation of novel gamma-carboline analogues of Dimebon as potent 5-HT6 receptor antagonists. | Bioorganic & medicinal chemistry letters 20090615 |
| [Progress in the research on multi-target-directed drugs against Alzheimer's disease]. | Yao xue xue bao = Acta pharmaceutica Sinica 20090301 |
| [Therapy of Alzheimer disease]. | Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology 20090301 |
| Alzheimer's disease: on the verges of treatment and prevention. | The Lancet. Neurology 20090101 |
| Progress in Alzheimer's disease drug discovery: an update. | Current opinion in investigational drugs (London, England : 2000) 20090101 |
| A promising new treatment for Alzheimer's disease? | The Lancet. Neurology 20080901 |
| Current and future therapy in Alzheimer's disease. | Fundamental & clinical pharmacology 20080601 |
| Evaluation of Dimebon in cellular model of Huntington's disease. | Molecular neurodegeneration 20080101 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| [Mitochondria as the target for neuroprotectors]. | Vestnik Rossiiskoi akademii meditsinskikh nauk 20050101 |
| Comparative study of action mechanisms of dimebon and memantine on AMPA- and NMDA-subtypes glutamate receptors in rat cerebral neurons. | Bulletin of experimental biology and medicine 20031101 |
| Mitochondria as a target for neurotoxins and neuroprotective agents. | Annals of the New York Academy of Sciences 20030501 |
| Antihistamine agent Dimebon as a novel neuroprotector and a cognition enhancer. | Annals of the New York Academy of Sciences 20010601 |
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