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35543-24-9 | Buflomedil hydrochloride
CAS No: 35543-24-9 Catalog No: AG003DT5 MDL No:MFCD00078965
Product Description
Catalog Number:
AG003DT5
Chemical Name:
Buflomedil hydrochloride
CAS Number:
35543-24-9
Molecular Formula:
C17H26ClNO4
Molecular Weight:
343.8456
MDL Number:
MFCD00078965
IUPAC Name:
4-pyrrolidin-1-yl-1-(2,4,6-trimethoxyphenyl)butan-1-one;hydrochloride
InChI:
InChI=1S/C17H25NO4.ClH/c1-20-13-11-15(21-2)17(16(12-13)22-3)14(19)7-6-10-18-8-4-5-9-18;/h11-12H,4-10H2,1-3H3;1H
InChI Key:
ZDPACSAHMZADFZ-UHFFFAOYSA-N
SMILES:
COc1cc(OC)cc(c1C(=O)CCC[NH+]1CCCC1)OC.[Cl-]
EC Number:
252-611-9
UNII:
3J944AFS8S
NSC Number:
759291
Properties
Complexity:
330
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
343.155g/mol
Formal Charge:
0
Heavy Atom Count:
23
Hydrogen Bond Acceptor Count:
5
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
343.848g/mol
Monoisotopic Mass:
343.155g/mol
Rotatable Bond Count:
8
Topological Polar Surface Area:
48A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
| Title | Journal |
|---|---|
| Safety profile assessment of buflomedil: an overview of adverse reactions between 1975 and 2011. | Pharmacoepidemiology and drug safety 20121101 |
| [Microbial transformation of buflomedil by Cunninghamella blakesleana AS 3.153]. | Yao xue xue bao = Acta pharmaceutica Sinica 20120701 |
| The value of population pharmacokinetics and simulation for postmarketing safety evaluation of dosing guidelines for drugs with a narrow therapeutic index: buflomedil as a case study. | Fundamental & clinical pharmacology 20120401 |
| Vasoactive agent buflomedil up-regulated expression of vascular endothelial growth factor in a rat model of sciatic nerve crush injury. | Indian journal of pharmacology 20120101 |
| Safety of subcutaneous microinjections (mesotherapy) in musicians. | Medical problems of performing artists 20110601 |
| Effects of buflomedil on skin blood flow in patients with type 2 diabetes mellitus without overt micro- or macroangiopathy. | International angiology : a journal of the International Union of Angiology 20110401 |
| Buflomedil: still too many fatal cardiac and neurological events. | Prescrire international 20110401 |
| A controlled trial of a prostacyclin and rt-PA in the treatment of severe frostbite. | The New England journal of medicine 20110113 |
| Influence of pharmacological treatment on blood flow and muscle perfusion in patients with obliterative atheromatosis assessed with isotopic methods. A pilot study. | Medical science monitor : international medical journal of experimental and clinical research 20101201 |
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
| [Addition of antithrombosis in situ in the case of digital replantation: preliminary prospective study of 13 cases]. | Chirurgie de la main 20101001 |
| [Multicentric study of thrombosis prevention in upper-extremity microsurgery. Survey at the Fesum centers]. | Chirurgie de la main 20100401 |
| Effects of buflomedil and pentoxifylline on hamster skin-flap microcirculation: prediction of flap viability using orthogonal polarization spectral imaging. | Clinics (Sao Paulo, Brazil) 20090801 |
| Buflomedil: potential new indications for an old agent. | International angiology : a journal of the International Union of Angiology 20090601 |
| Pharmacologic therapy for intermittent claudication. | Pharmacotherapy 20090501 |
| Cutaneous granulomatous reaction from mesotherapy. | Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 20090201 |
| Bias in benefit-risk appraisal in older products: the case of buflomedil for intermittent claudication. | Drug safety 20090101 |
| Letter by De Backer et al regarding article, 'Oral buflomedil in the prevention of cardiovascular events in patients with peripheral arterial obstructive disease: a randomized, placebo-controlled, 4-year study'. | Circulation 20080902 |
| Simultaneous FTIR spectroscopic imaging and visible photography to monitor tablet dissolution and drug release. | Pharmaceutical research 20080401 |
| The use of buflomedil in reduction mammaplasty for a previously irradiated breast: a case report. | Aesthetic plastic surgery 20080301 |
| Oral buflomedil in the prevention of cardiovascular events in patients with peripheral arterial obstructive disease: a randomized, placebo-controlled, 4-year study. | Circulation 20080212 |
| Buflomedil in peripheral arterial disease: trials and tribulations. | Circulation 20080212 |
| Buflomedil for intermittent claudication. | The Cochrane database of systematic reviews 20080123 |
| Buflomedil for intermittent claudication. | The Cochrane database of systematic reviews 20071017 |
| Buflomedil: still seizures and cardiac disorders. Too many patients are exposed to an unjustified risk of serious adverse effects. | Prescrire international 20070201 |
| Comparison between intravenous iloprost and vasoactive drugs in limb ischemia IIB severe. A retrospective analysis. | Minerva cardioangiologica 20060601 |
| The effects of prostaglandin E-1 in patients with intermittent claudication. | Cardiovascular & hematological disorders drug targets 20060601 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| Assemblage of novel release modules for the development of adaptable drug delivery systems. | Journal of controlled release : official journal of the Controlled Release Society 20060310 |
| Facilitated column selection in pharmaceutical analyses using a simple column classification system. | Journal of chromatography. A 20060106 |
| Buflomedil and pentoxifylline in the viability of dorsal cutaneous flaps of rats treated with nicotine. | Journal of plastic, reconstructive & aesthetic surgery : JPRAS 20060101 |
| [Severe peripheral ischemia of rare origin]. | Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20060101 |
| Effect of loading on a swelling-controlled drug delivery system studied by optical techniques. | Journal of controlled release : official journal of the Controlled Release Society 20050103 |
| Protective effect of buflomedil in a rat model of moderate cerebral ischemia. | Arzneimittel-Forschung 20050101 |
| Inhibitory effect of buflomedil on prostate alpha1A adrenoceptor in the Wistar rat. | Neuroscience letters 20040902 |
| [Secondary prevention and conservative therapy of obliterative arteriosclerosis]. | Orvosi hetilap 20040516 |
| Suicide by buflomedil HCl: a case report. | Journal of clinical forensic medicine 20040201 |
| [Suicidal buflomedil intoxication]. | Archiv fur Kriminologie 20040101 |
| Rapid HPLC measurement of buflomedil in plasma in poisoning cases. | Biomedical chromatography : BMC 20021001 |
| Rheological and biochemical examination of red blood cells after treatment with different pharmacological and toxic substances. | Clinical hemorheology and microcirculation 20020101 |
| [Sudden hearing loss. Clinical case]. | Anales otorrinolaringologicos ibero-americanos 20020101 |
| Clinical and hemorheological effects of buflomedil in diabetic subjects with intermittent claudication. | International angiology : a journal of the International Union of Angiology 20011201 |
| [Retrograde venous perfusion (RVP in ulcero-mutilating neuropathy]. | Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20011001 |
| [Clinical study of the effect of buflomedil on peripheral neuropathy in diabetic patients]. | Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University 20010628 |
| [Myoclonic coma and severe cardiac insufficiency in a patient with arteritis]. | La Revue de medecine interne 20010601 |
| Effects of buflomedil on early carotid atherosclerosis in Type 2 diabetic patients. | International angiology : a journal of the International Union of Angiology 20010601 |
| Heparin protects local skin microcirculation in 210 minutes-long intravital microscopy observations under general anaesthesia. | European journal of medical research 20010420 |
| Translocation of drug particles in HPMC matrix gel layer: effect of drug solubility and influence on release rate. | Journal of controlled release : official journal of the Controlled Release Society 20010223 |
| Buflomedil for intermittent claudication. | The Cochrane database of systematic reviews 20010101 |
| Ticlopidine-pentoxifylline combination in the treatment of atherosclerosis and the prevention of cerebrovascular accidents. | The Journal of international medical research 19890101 |
| [Emetic and catalepsy-inducing actions of buflomedil]. | Nihon yakurigaku zasshi. Folia pharmacologica Japonica 19881201 |
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