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33818-15-4 | Citicoline sodium
CAS No: 33818-15-4 Catalog No: AG003P0A MDL No:MFCD00037486
Product Description
Catalog Number:
AG003P0A
Chemical Name:
Citicoline sodium
CAS Number:
33818-15-4
Molecular Formula:
C14H25N4NaO11P2
Molecular Weight:
510.3058
MDL Number:
MFCD00037486
IUPAC Name:
sodium;[[(2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] 2-(trimethylazaniumyl)ethyl phosphate
InChI:
InChI=1S/C14H26N4O11P2.Na/c1-18(2,3)6-7-26-30(22,23)29-31(24,25)27-8-9-11(19)12(20)13(28-9)17-5-4-10(15)16-14(17)21;/h4-5,9,11-13,19-20H,6-8H2,1-3H3,(H3-,15,16,21,22,23,24,25);/q;+1/p-1/t9-,11-,12-,13-;/m1./s1
InChI Key:
YWAFNFGRBBBSPD-OCMLZEEQSA-M
SMILES:
O[C@@H]1[C@@H](COP(=O)(OP(=O)([O-])[O-])OCC[N+](C)(C)C)O[C@H]([C@@H]1O)n1ccc(nc1=O)N.[Na+]
UNII:
7XQ5AKD9YD
Properties
Complexity:
813
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2
Defined Atom Stereocenter Count:
4
Defined Bond Stereocenter Count:
0
Exact Mass:
510.089g/mol
Formal Charge:
0
Heavy Atom Count:
32
Hydrogen Bond Acceptor Count:
11
Hydrogen Bond Donor Count:
3
Isotope Atom Count:
0
Molecular Weight:
510.308g/mol
Monoisotopic Mass:
510.089g/mol
Rotatable Bond Count:
10
Topological Polar Surface Area:
216A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
| Title | Journal |
|---|---|
| Citicoline (CDP-choline) increases Sirtuin1 expression concomitant to neuroprotection in experimental stroke. | Journal of neurochemistry 20130901 |
| A rapid LC-ESI-MS/MS method for the quantitation of choline, an active metabolite of citicoline: Application to in vivo pharmacokinetic and bioequivalence study in Indian healthy male volunteers. | Journal of pharmaceutical and biomedical analysis 20121201 |
| Citicoline in pre-clinical animal models of stroke: a meta-analysis shows the optimal neuroprotective profile and the missing steps for jumping into a stroke clinical trial. | Journal of neurochemistry 20121001 |
| CDP-choline at high doses is as effective as i.v. thrombolysis in experimental animal stroke. | Neurological research 20120901 |
| Stroke: Treatment for acute stroke--the end of the citicoline saga. | Nature reviews. Neurology 20120901 |
| Citicoline in the treatment of acute ischaemic stroke: an international, randomised, multicentre, placebo-controlled study (ICTUS trial). | Lancet (London, England) 20120728 |
| How effective is citicoline for acute ischaemic stroke? | Lancet (London, England) 20120728 |
| Citicoline enhances neuroregenerative processes after experimental stroke in rats. | Stroke 20120701 |
| Improvements in quantitative EEG following consumption of a natural citicoline-enhanced beverage. | International journal of food sciences and nutrition 20120601 |
| Intraperitoneal administration of CDP-choline or a combination of cytidine plus choline improves nerve regeneration and functional recovery in a rat model of sciatic nerve injury. | Neurological research 20120401 |
| Efficacy of cytidine-5'-diphosp-bocholine combined with compound anisodine in the treatment of early optic nerve contusion. | Eye science 20120301 |
| Intravenous CDP-choline activates neurons in supraoptic and paraventricular nuclei and induces hormone secretion. | Brain research bulletin 20120210 |
| CDP-choline treatment induces brain plasticity markers expression in experimental animal stroke. | Neurochemistry international 20120201 |
| Probably role of citicoline in stroke rehabilitation: review of the literature. | Revista de neurologia 20120201 |
| Retrospective and observational study to assess the efficacy of citicoline in elderly patients suffering from stupor related to complex geriatric syndrome. | Clinical interventions in aging 20120101 |
| [Neuroprotective treatment with citicoline (ceraxon) in patients with ischemic stroke]. | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20120101 |
| [Influence of neuroprotectors with choline-positive action on the level of brain-injury markers during acute ischemic stroke]. | Eksperimental'naia i klinicheskaia farmakologiia 20120101 |
| Prevention of epidural fibrosis in rats by local or systemic administration of citicoline. | Turkish neurosurgery 20120101 |
| Phosphatidylcholine protects against steatosis in mice but not non-alcoholic steatohepatitis. | Biochimica et biophysica acta 20111201 |
| CDP-choline and its endogenous metabolites, cytidine and choline, promote the nerve regeneration and improve the functional recovery of injured rat sciatic nerves. | Neurological research 20110901 |
| The antihyperalgesic effect of cytidine-5'-diphosphate-choline in neuropathic and inflammatory pain models. | Behavioural pharmacology 20110901 |
| Investigational therapies for ischemic stroke: neuroprotection and neurorecovery. | Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20110701 |
| CDP-choline treatment increases circulating endothelial progenitor cells in acute ischemic stroke. | Neurological research 20110701 |
| Eight weeks of citicoline treatment does not perturb sleep/wake cycles in cocaine-dependent adults. | Pharmacology, biochemistry, and behavior 20110601 |
| CDP-choline as a biological supplement during neurorecovery: a focused review. | PM & R : the journal of injury, function, and rehabilitation 20110601 |
| Effect of choline-containing phospholipids on brain cholinergic transporters in the rat. | Journal of the neurological sciences 20110315 |
| CDP-choline-induced contractions in the mouse gastric fundus through purinoceptors and Rho/Rho-kinase signalling. | Life sciences 20110314 |
| Citicoline: pharmacological and clinical review, 2010 update. | Revista de neurologia 20110314 |
| Simple diffusion delivery via brain interstitial route for the treatment of cerebral ischemia. | Science China. Life sciences 20110301 |
| Effects of daily treatment with citicoline: a double-blind, placebo-controlled study in cocaine-dependent volunteers. | Journal of addiction medicine 20110301 |
| Serial MRI study of the enhanced therapeutic effects of liposome-encapsulated citicoline in cerebral ischemia. | International journal of pharmaceutics 20110227 |
| Specificity and rate of human and mouse liver and plasma phosphatidylcholine synthesis analyzed in vivo. | Journal of lipid research 20110201 |
| Citicoline preclinical and clinical update 2009-2010. | Stroke 20110101 |
| Citicoline in vascular cognitive impairment and vascular dementia after stroke. | Stroke 20110101 |
| Neuroprotection and recovery: recent data at the bench on citicoline. | Stroke 20110101 |
| A random effects variance shift model for detecting and accommodating outliers in meta-analysis. | BMC medical research methodology 20110101 |
| Human tissue kallikrein promoted activation of the ipsilesional sensorimotor cortex after acute cerebral infarction. | European neurology 20110101 |
| Neuroprotective effects of citidine-5-diphosphocholine on impaired spatial memory in a rat model of cerebrovascular dementia. | Journal of pharmacological sciences 20110101 |
| Greatly improved neuroprotective efficiency of citicoline by stereotactic delivery in treatment of ischemic injury. | Drug delivery 20110101 |
| [The effect of parenteral citicoline on visual functions and life quality of patients with primary open-angle glaucoma]. | Vestnik oftalmologii 20110101 |
| [Comparative aspects of using neuroprotectors in the management of patients with ischemic stroke]. | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20110101 |
| [Ceraxon (citicoline) in the treatment of the mild cognitive impairment syndrome]. | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20110101 |
| [Comparison of efficacy of different neurometabolic and vasoactive medicines in ischemic stroke patients's rehabilitation]. | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20110101 |
| Mannosylated liposomal cytidine 5' diphosphocholine prevent age related global moderate cerebral ischemia reperfusion induced mitochondrial cytochrome c release in aged rat brain. | Neuroscience 20101229 |
| Citicoline, use in cognitive decline: vascular and degenerative. | Journal of the neurological sciences 20101215 |
| Short-term administration of uridine increases brain membrane phospholipid precursors in healthy adults: a 31-phosphorus magnetic resonance spectroscopy study at 4T. | Bipolar disorders 20101201 |
| Production of cytidine 5'-diphosphorylcholine with high utilization of ATP by whole cells of Saccharomyces cerevisiae. | Bioresource technology 20101101 |
| Citicoline and postconditioning provides neuroprotection in a rat model of ischemic spinal cord injury. | Acta neurochirurgica 20100601 |
| Choline or CDP-choline attenuates coagulation abnormalities and prevents the development of acute disseminated intravascular coagulation in dogs during endotoxemia. | Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20100601 |
| Citicoline for acute ischemic stroke in Mexican hospitals: a retrospective postmarketing analysis. | Methods and findings in experimental and clinical pharmacology 20100601 |
| Differential expression of choline kinase isoforms in skeletal muscle explains the phenotypic variability in the rostrocaudal muscular dystrophy mouse. | Biochimica et biophysica acta 20100401 |
| Neurochemical alterations in methamphetamine-dependent patients treated with cytidine-5'-diphosphate choline: a longitudinal proton magnetic resonance spectroscopy study. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20100401 |
| Effect of repeatedly given CDP-choline on cardiovascular and tissue injury in spinal shock conditions: investigation of the acute phase. | The Journal of pharmacy and pharmacology 20100401 |
| Effects of citicoline used alone and in combination with mild hypothermia on apoptosis induced by focal cerebral ischemia in rats. | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20100201 |
| Involvement of the histaminergic system in cytidine 5'-diphosphocholine-induced reversal of critical haemorrhagic hypotension in rats. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20100201 |
| Molecular mechanisms involved in farnesol-induced apoptosis. | Cancer letters 20100128 |
| Citicoline affects appetite and cortico-limbic responses to images of high-calorie foods. | The International journal of eating disorders 20100101 |
| The protective effects of propofol and citicoline combination in experimental head injury in rats. | Turkish neurosurgery 20100101 |
| Effect of recombinant human erythropoietin on serum S100B protein and interleukin-6 levels after traumatic brain injury in the rat. | Neurologia medico-chirurgica 20100101 |
| [Efficacy and safety of the combined therapy with citicholine and actovegin in the acute period of ischemic stroke]. | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20100101 |
| The citicoline brain injury treatment (COBRIT) trial: design and methods. | Journal of neurotrauma 20091201 |
| Effect of NH4+ and glycerol on cytidine 5'-diphosphocholine synthesis in Saccharomyces cerevisiae. | Bioresource technology 20091001 |
| Choline or CDP-choline alters serum lipid responses to endotoxin in dogs and rats: involvement of the peripheral nicotinic acetylcholine receptors. | Shock (Augusta, Ga.) 20090901 |
| Citicoline (CDP-choline): What role in the treatment of complications of infectious diseases. | The international journal of biochemistry & cell biology 20090701 |
| ATF6alpha induces XBP1-independent expansion of the endoplasmic reticulum. | Journal of cell science 20090515 |
| Understanding the muscular dystrophy caused by deletion of choline kinase beta in mice. | Biochimica et biophysica acta 20090501 |
| The effect of peripherally administered CDP-choline in an acute inflammatory pain model: the role of alpha7 nicotinic acetylcholine receptor. | Anesthesia and analgesia 20090501 |
| A robust quantitative solid phase immunoassay for the acute phase protein C-reactive protein (CRP) based on cytidine 5'-diphosphocholine coupled dendrimers. | Journal of immunological methods 20090415 |
| Efficacy of citicoline as an acute stroke treatment. | Expert opinion on pharmacotherapy 20090401 |
| Efficacy and safety of oral citicoline in acute ischemic stroke: drug surveillance study in 4,191 cases. | Methods and findings in experimental and clinical pharmacology 20090401 |
| Evaluation of a sequential global test of improved recovery following stroke as applied to the ICTUS trial of citicoline. | Pharmaceutical statistics 20090101 |
| Multifunctional actions of approved and candidate stroke drugs. | Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20090101 |
| Single- and repeated-dose oral toxicity studies of citicoline free-base (choline cytidine 5'-pyrophosphate) in Sprague-Dawley rats. | International journal of toxicology 20090101 |
| [The use of citicoline in the acute cerebral stroke]. | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20090101 |
| Effects of cytidine 5'-diphosphocholine (CDP-choline) on the thermal nociceptive threshold in streptozotocin-induced diabetic mice. | European journal of pharmacology 20081119 |
| Breast cancer is associated with an increase in the activity and expression of cholinephosphotransferase in rats. | Life sciences 20081107 |
| Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy. | NMR in biomedicine 20081101 |
| Effect of choline-containing phospholipids on transglutaminase activity in primary astroglial cell cultures. | Clinical and experimental hypertension (New York, N.Y. : 1993) 20081101 |
| CDP-choline prevents cardiac arrhythmias and lethality induced by short-term myocardial ischemia-reperfusion injury in the rat: involvement of central muscarinic cholinergic mechanisms. | Naunyn-Schmiedeberg's archives of pharmacology 20080901 |
| Central choline suppresses plasma renin response to graded haemorrhage in rats. | Clinical and experimental pharmacology & physiology 20080901 |
| Cytidine-5-diphosphocholine supplement in early life induces stable increase in dendritic complexity of neurons in the somatosensory cortex of adult rats. | Neuroscience 20080813 |
| Choline, CDP-choline or phosphocholine increases plasma glucagon in rats: involvement of the peripheral autonomic nervous system. | European journal of pharmacology 20080728 |
| Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase: a novel metallophosphoesterase family preferentially expressed in rodent immune cells. | The Biochemical journal 20080701 |
| Cholinomimetic agents and neurocognitive impairment following head injury: a systematic review. | Brain injury 20080701 |
| [Clinical effect of ligustrazine combined with citicoline for treatment of diabetic peripheral neuropathy]. | Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20080701 |
| Cytidine-5'-diphosphocholine (Citicoline): a pilot study in patients with non-arteritic ischaemic optic neuropathy. | European journal of neurology 20080501 |
| Citicoline. Monograph. | Alternative medicine review : a journal of clinical therapeutic 20080301 |
| Effects of CDP-choline and the combination of CDP-choline and galantamine differ in an animal model of schizophrenia: development of a selective alpha7 nicotinic acetylcholine receptor agonist strategy. | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20080201 |
| Peripheral administration of CDP-choline and its cholinergic metabolites increases serum insulin: muscarinic and nicotinic acetylcholine receptors are both involved in their actions. | Neuroscience letters 20080124 |
| Effect of oral CDP-choline on visual function in young amblyopic patients. | Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20080101 |
| Delayed post-ischemic administration of CDP-choline increases EAAT2 association to lipid rafts and affords neuroprotection in experimental stroke. | Neurobiology of disease 20080101 |
| Peripheral administration of CDP-choline, phosphocholine or choline increases plasma adrenaline and noradrenaline concentrations. | Autonomic & autacoid pharmacology 20080101 |
| First administration of cytidine diphosphocholine and galantamine in schizophrenia: a sustained alpha7 nicotinic agonist strategy. | Clinical neuropharmacology 20080101 |
| Efficiency of citicoline in increasing muscular strength of patients with nontraumatic cerebral hemorrhage: a double-blind randomized clinical trial. | Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 20080101 |
| CDP-choline protects motor neurons against apoptotic changes in a model of chronic glutamate excitotoxicity in vitro. | Folia neuropathologica 20080101 |
| CDP-choline (citicoline) attenuates brain damage in a rat model of birth asphyxia. | Acta neurobiologiae experimentalis 20080101 |
| Evidence of the neuroprotective role of citicoline in glaucoma patients. | Progress in brain research 20080101 |
| Citicoline: update on a promising and widely available agent for neuroprotection and neurorepair. | Reviews in neurological diseases 20080101 |
| Cardiovascular effects of CDP-choline and its metabolites: involvement of peripheral autonomic nervous system. | European journal of pharmacology 20071222 |
| Citicoline is not protective in experimental models of Huntington's disease. | Neurobiology of aging 20071201 |
| Citicoline improves functional recovery, promotes nerve regeneration, and reduces postoperative scarring after peripheral nerve surgery in rats. | Surgical neurology 20071201 |
| Citicoline reduces upregulated clusterin following kainic acid injection in the rat retina. | Current eye research 20071201 |
| A randomized, placebo-controlled trial of citicoline add-on therapy in outpatients with bipolar disorder and cocaine dependence. | Journal of clinical psychopharmacology 20071001 |
| Choline induces transcriptional repression and proteasomal degradation of the malarial phosphoethanolamine methyltransferase. | Eukaryotic cell 20070901 |
| CDP-choline reduces dopaminergic cell loss induced by MPP(+) and glutamate in primary mesencephalic cell culture. | The International journal of neuroscience 20070701 |
| Cholinergic precursors in the treatment of cognitive impairment of vascular origin: ineffective approaches or need for re-evaluation? | Journal of the neurological sciences 20070615 |
| Possible involvement of supraspinal opioid and GABA receptors in CDP-choline-induced antinociception in acute pain models in rats. | Neuroscience letters 20070613 |
| Interventions for preventing delirium in hospitalised patients. | The Cochrane database of systematic reviews 20070418 |
| A chronic treatment with CDP-choline improves functional recovery and increases neuronal plasticity after experimental stroke. | Neurobiology of disease 20070401 |
| Intraperitoneal administration of CDP-choline and its cholinergic and pyrimidinergic metabolites induce hyperglycemia in rats: involvement of the sympathoadrenal system. | Archives of physiology and biochemistry 20070101 |
| Citicoline and lithium rescue retinal ganglion cells following partial optic nerve crush in the rat. | Experimental eye research 20061101 |
| The antinociceptive effects of centrally administered CDP-choline on acute pain models in rats: the involvement of cholinergic system. | Brain research 20061030 |
| Citicoline--the first effective neuroprotectant to be combined with thrombolysis in acute ischemic stroke? | Journal of the neurological sciences 20060925 |
| Effect of combined therapy with thrombolysis and citicoline in a rat model of embolic stroke. | Journal of the neurological sciences 20060925 |
| Citicoline: pharmacological and clinical review, 2006 update. | Methods and findings in experimental and clinical pharmacology 20060901 |
| Citicoline (Cognizin) in the treatment of cognitive impairment. | Clinical interventions in aging 20060901 |
| Localization of the phosphoethanolamine methyltransferase of the human malaria parasite Plasmodium falciparum to the Golgi apparatus. | The Journal of biological chemistry 20060728 |
| Medical treatment of amblyopia: present state and perspectives. | Strabismus 20060601 |
| Evaluation of the neuroprotective effects of citicoline after experimental spinal cord injury: improved behavioral and neuroanatomical recovery. | Neurochemical research 20060601 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| Action of citicoline on rat retinal expression of extracellular-signal-regulated kinase (ERK1/2). | Brain research 20060407 |
| CDP-choline significantly restores phosphatidylcholine levels by differentially affecting phospholipase A2 and CTP: phosphocholine cytidylyltransferase after stroke. | The Journal of biological chemistry 20060310 |
| Vegetable lipid sources affect in vitro biosynthesis of triacylglycerols and phospholipids in the intestine of sea bream (Sparus aurata). | The British journal of nutrition 20060301 |
| [Effect of citicoline on spatial learning and memory of rats after focal cerebral ischemia]. | Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20060201 |
| Intravenous administration of choline or cdp-choline improves platelet count and platelet closure times in endotoxin-treated dogs. | Shock (Augusta, Ga.) 20060101 |
| Citicoline in intracerebral haemorrhage: a double-blind, randomized, placebo-controlled, multi-centre pilot study. | Cerebrovascular diseases (Basel, Switzerland) 20060101 |
| Radioprotective effect of transferrin targeted citicoline liposomes. | Journal of drug targeting 20060101 |
| Cytidine and uridine increase striatal CDP-choline levels without decreasing acetylcholine synthesis or release. | Cellular and molecular neurobiology 20060101 |
| Targets of cytoprotection in acute ischemic stroke: present and future. | Cerebrovascular diseases (Basel, Switzerland) 20060101 |
| Neurorepair versus neuroprotection in stroke. | Cerebrovascular diseases (Basel, Switzerland) 20060101 |
| Thrombolysis and neuroprotection in cerebral ischemia. | Cerebrovascular diseases (Basel, Switzerland) 20060101 |
| Cytidine 5'-diphosphocholine restores blood flow of superior mesenteric and renal arteries and prolongs survival time in haemorrhaged anaesthetized rats. | Clinical and experimental pharmacology & physiology 20060101 |
| Glycerophosphocholine catabolism as a new route for choline formation for phosphatidylcholine synthesis by the Kennedy pathway. | The Journal of biological chemistry 20051118 |
| Effects of citicoline on experimental spinal cord injury. | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20051101 |
| Oral uridine-5'-monophosphate (UMP) increases brain CDP-choline levels in gerbils. | Brain research 20051005 |
| CDP-choline liposomes provide significant reduction in infarction over free CDP-choline in stroke. | Brain research 20051005 |
| Neuroprotective effect of citicoline against KA-induced neurotoxicity in the rat retina. | Experimental eye research 20050901 |
| Neuroprotective effect of citicoline on retinal cell damage induced by kainic acid in rats. | Korean journal of ophthalmology : KJO 20050901 |
| Physiological regulation of phospholipid methylation alters plasma homocysteine in mice. | The Journal of biological chemistry 20050805 |
| Effects of simvastatin on the expression of intercellular adhesion molecule-1 mRNA in neonatal brain with hypoxic-ischemic damage. | Journal of nanoscience and nanotechnology 20050801 |
| Citicoline inhibits MAP kinase signalling pathways after focal cerebral ischaemia. | Neurochemical research 20050801 |
| Effect of Xuesaitong soft capsule on hemorrheology and in auxiliarily treating patients with acute cerebral infarction. | Chinese journal of integrative medicine 20050601 |
| [A case of interval form of carbon monoxide poisoning with a remarkable recovery]. | Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 20050501 |
| Cytidinediphosphocholine (CDP-choline) for cognitive and behavioural disturbances associated with chronic cerebral disorders in the elderly. | The Cochrane database of systematic reviews 20050418 |
| Stachybotrys chartarum alters surfactant-related phospholipid synthesis and CTP:cholinephosphate cytidylyltransferase activity in isolated fetal rat type II cells. | Toxicological sciences : an official journal of the Society of Toxicology 20050301 |
| Neuroprotection afforded by prior citicoline administration in experimental brain ischemia: effects on glutamate transport. | Neurobiology of disease 20050301 |
| Progressive morphometric and cognitive changes in vascular dementia. | Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists 20050301 |
| Effects of cataractogenesis on the CDP-choline pathway: increased phospholipid synthesis in lenses from galactosemic rats and 13/N guinea pigs. | Ophthalmic research 20050101 |
| Dietary CDP-choline supplementation prevents memory impairment caused by impoverished environmental conditions in rats. | Learning & memory (Cold Spring Harbor, N.Y.) 20050101 |
| Cytidine 5'-diphosphocholine (CDP-choline) in stroke and other CNS disorders. | Neurochemical research 20050101 |
| Electrophysiological assessment of glaucomatous visual dysfunction during treatment with cytidine-5'-diphosphocholine (citicoline): a study of 8 years of follow-up. | Documenta ophthalmologica. Advances in ophthalmology 20050101 |
| The new approaches to preservation of graft cell integrity in preservation for transplantation. | Annals of transplantation 20050101 |
| CDP-choline increases plasma ACTH and potentiates the stimulated release of GH, TSH and LH: the cholinergic involvement. | Fundamental & clinical pharmacology 20041001 |
| Elevated erythrocyte CDP-choline levels associated with beta-thalassaemia in patients with transfusion independent anaemia. | Nucleosides, nucleotides & nucleic acids 20041001 |
| Characterization of a lipid activated CTP:phosphocholine cytidylyltransferase from Drosophila melanogaster. | Biochimica et biophysica acta 20040705 |
| A choline-deficient diet in mice inhibits neither the CDP-choline pathway for phosphatidylcholine synthesis in hepatocytes nor apolipoprotein B secretion. | The Journal of biological chemistry 20040604 |
| Chronic treatment with a precursor of cellular phosphatidylcholine ameliorates morphological and behavioral effects of aging in the mouse [correction of rat] hippocampus. | Annals of the New York Academy of Sciences 20040601 |
| Regulation of phosphatidylcholine biosynthesis under salt stress involves choline kinases in Arabidopsis thaliana. | FEBS letters 20040521 |
| Cytidine-5'-diphosphocholine affects CTP-phosphocholine cytidylyltransferase and lyso-phosphatidylcholine after transient brain ischemia. | Journal of neuroscience research 20040501 |
| Therapeutic applications of citicoline for stroke and cognitive dysfunction in the elderly: a review of the literature. | Alternative medicine review : a journal of clinical therapeutic 20040301 |
| The effects of citicoline and lamotrigine alone and in combination following permanent middle cerebral artery occlusion in rats. | The International journal of neuroscience 20040201 |
| Centrally injected CDP-choline increases plasma vasopressin levels by central cholinergic activation. | Fundamental & clinical pharmacology 20040201 |
| Cell membranes and apoptosis: role of cardiolipin, phosphatidylcholine, and anticancer lipid analogues. | Biochemistry and cell biology = Biochimie et biologie cellulaire 20040201 |
| Phospholipid biosynthesis in mammalian cells. | Biochemistry and cell biology = Biochimie et biologie cellulaire 20040201 |
| A CDP-choline pathway for phosphatidylcholine biosynthesis in Treponema denticola. | Molecular microbiology 20040101 |
| Cytidinediphosphocholine (CDP choline) for cognitive and behavioural disturbances associated with chronic cerebral disorders in the elderly. | The Cochrane database of systematic reviews 20040101 |
| Brain cholinesterases: III. Future perspectives of AD research and clinical practice. | Medical hypotheses 20040101 |
| Neuroimaging correlates of dementia rating scale performance at baseline and 12-month follow-up among patients with vascular dementia. | Journal of geriatric psychiatry and neurology 20031201 |
| Neuroprotective effect of citicoline in 6-hydroxydopamine-lesioned rats and in 6-hydroxydopamine-treated SH-SY5Y human neuroblastoma cells. | Journal of the neurological sciences 20031115 |
| Phospholipase A2, hydroxyl radicals, and lipid peroxidation in transient cerebral ischemia. | Antioxidants & redox signaling 20031001 |
| Citicoline decreases phospholipase A2 stimulation and hydroxyl radical generation in transient cerebral ischemia. | Journal of neuroscience research 20030801 |
| Phosphorylation of Saccharomyces cerevisiae CTP synthetase at Ser424 by protein kinases A and C regulates phosphatidylcholine synthesis by the CDP-choline pathway. | The Journal of biological chemistry 20030627 |
| Regulation of the CDP-choline pathway by sterol regulatory element binding proteins involves transcriptional and post-transcriptional mechanisms. | The Biochemical journal 20030615 |
| Dietary cytidine (5')-diphosphocholine supplementation protects against development of memory deficits in aging rats. | Progress in neuro-psychopharmacology & biological psychiatry 20030601 |
| Stimulation of CDP-choline synthesis by uridine or cytidine in PC12 rat pheochromocytoma cells. | Brain research 20030509 |
| Intravenously injected CDP-choline increases blood pressure and reverses hypotension in haemorrhagic shock: effect is mediated by central cholinergic activation. | European journal of pharmacology 20030509 |
| Cytidinediphosphocholine treatment to decrease traumatic brain injury-induced hippocampal neuronal death, cortical contusion volume, and neurological dysfunction in rats. | Journal of neurosurgery 20030401 |
| The two biosynthetic routes leading to phosphatidylcholine in yeast produce different sets of molecular species. Evidence for lipid remodeling. | Biochemistry 20030318 |
| Oral citicoline treatment improves visual pathway function in glaucoma. | Medical science monitor : international medical journal of experimental and clinical research 20030301 |
| Clinical correlates of cognitive decline in vascular dementia. | Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology 20030301 |
| Effects of cytidine 5'-diphosphocholine on plasma homocysteine levels in rat. | Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20030201 |
| CDP-choline prevents glutamate-mediated cell death in cerebellar granule neurons. | Journal of molecular neuroscience : MN 20030201 |
| Effects of citicholine and dimethylsulfoxide on transepithelial transport of passively diffused drugs in the Caco-2 cell culture model. | International journal of pharmaceutics 20030130 |
| Combined nimodipine and citicoline reduce infarct size, attenuate apoptosis and increase bcl-2 expression after focal cerebral ischemia. | Neuroscience 20030101 |
| Effect of CDP-choline on hippocampal acetylcholinesterase and Na+,K(+)-ATPase in adult and aged rats. | Zeitschrift fur Naturforschung. C, Journal of biosciences 20030101 |
| Effects of cataractogenesis on the CDP-choline pathway: changes in ATP concentration and phosphocholine synthesis during and after exposure of rat lenses to sugars in vitro and in vivo. | Ophthalmic research 20030101 |
| Long-term citicoline (cytidine diphosphate choline) use in patients with vascular dementia: neuroimaging and neuropsychological outcomes. | Cerebrovascular diseases (Basel, Switzerland) 20030101 |
| 'Brain-specific' nutrients: a memory cure? | Nutrition (Burbank, Los Angeles County, Calif.) 20030101 |
| Citicoline increases glutathione redox ratio and reduces caspase-3 activation and cell death in staurosporine-treated SH-SY5Y human neuroblastoma cells. | Brain research 20021206 |
| Oral citicoline in acute ischemic stroke: an individual patient data pooling analysis of clinical trials. | Stroke 20021201 |
| Citicoline has a protective effect on damaged retinal ganglion cells in mouse culture retina. | Neuroreport 20021115 |
| Citicoline mechanisms and clinical efficacy in cerebral ischemia. | Journal of neuroscience research 20021015 |
| [Treatment of mild cognitive impairment: value of citicoline]. | Revista de neurologia 20021001 |
| Phosphorylation of Saccharomyces cerevisiae choline kinase on Ser30 and Ser85 by protein kinase A regulates phosphatidylcholine synthesis by the CDP-choline pathway. | The Journal of biological chemistry 20020920 |
| Clinical use of cholinomimetic agents: a review. | The Journal of head trauma rehabilitation 20020801 |
| Effects of ganglioside GM3 on phospholipid turnover of human leukemic J6-2 cells. | Neurochemical research 20020801 |
| Argipressin(4-8) upregulate CTP: phosphocholine cytidylyltransferase in rat hippocampal neurons. | Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica 20020701 |
| Quantifying heterogeneity in a meta-analysis. | Statistics in medicine 20020615 |
| Antidepressant-like effects of cytidine in the forced swim test in rats. | Biological psychiatry 20020601 |
| Cardiovascular effects of intracerebroventricularly injected CDP-choline in normotensive and hypotensive animals: the involvement of cholinergic system. | Naunyn-Schmiedeberg's archives of pharmacology 20020501 |
| CDP-choline reduces pro-caspase and cleaved caspase-3 expression, nuclear DNA fragmentation, and specific PARP-cleaved products of caspase activation following middle cerebral artery occlusion in the rat. | Neuropharmacology 20020501 |
| Chronic citicoline increases phosphodiesters in the brains of healthy older subjects: an in vivo phosphorus magnetic resonance spectroscopy study. | Psychopharmacology 20020501 |
| The serial position effect in mild and moderately severe vascular dementia. | Journal of the International Neuropsychological Society : JINS 20020501 |
| [Perspectives on the treatment of organic mental disorders by the use of nootropic agents]. | Voenno-meditsinskii zhurnal 20020501 |
| News about neuroprotectants for the treatment of stroke. | JAMA 20020313 |
| Pharmacodynamics of citicoline relevant to the treatment of glaucoma. | Journal of neuroscience research 20020115 |
| Citicoline: neuroprotective mechanisms in cerebral ischemia. | Journal of neurochemistry 20020101 |
| Citicoline treatment increases retinal dopamine content in rabbits. | Ophthalmic research 20020101 |
| Membrane stabilizer: citicoline. | Current medical research and opinion 20020101 |
| [Reaction times during citicoline treatment]. | La Clinica terapeutica 20020101 |
| Choline transport in Leishmania major promastigotes and its inhibition by choline and phosphocholine analogs. | Molecular and biochemical parasitology 20020101 |
| Application of 4-hydroxyantipyrine and acetaminophen O-sulfate as biodistribution promoter. | Biological & pharmaceutical bulletin 20011201 |
| Citicoline. Ferrer Internacional. | Current opinion in investigational drugs (London, England : 2000) 20011201 |
| A phase III randomized efficacy trial of 2000 mg citicoline in acute ischemic stroke patients. | Neurology 20011113 |
| [Curative effect of soybean lecithin on cerebral infarction]. | Zhonghua yi xue za zhi 20011110 |
| Effects of citicoline on phospholipid and glutathione levels in transient cerebral ischemia. | Stroke 20011001 |
| The effects of citicoline and/or MK-801 on survival, neurological and behavioral outcome of mice exposed to transient hyperglycemia and oligemic hypoxia. | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20011001 |
| [Use of procholinergics in the prevention of postoperative delirium in hip fracture surgery in the elderly. A randomized controlled trial]. | Revista de neurologia 20011001 |
| Effects of short-term citicoline treatment on acute cocaine intoxication and cardiovascular effects. | Psychopharmacology 20010901 |
| Choline deficiency induced by Mycoplasma fermentans enhances apoptosis of rat astrocytes. | FEMS microbiology letters 20010724 |
| [Neuroprotection in acute ischemic stroke. Practicability of guidelines for treatment]. | Revista de neurologia 20010501 |
| Ischemic brain injury caused by interrupted versus uninterrupted occlusion in hypotensive rats with subarachnoid hemorrhage: neuroprotective effects of citicoline. | Archives of physiology and biochemistry 20010401 |
| Highly saturated endonuclear phosphatidylcholine is synthesized in situ and colocated with CDP-choline pathway enzymes. | The Journal of biological chemistry 20010316 |
| Does CDP-choline modulate phospholipase activities after transient forebrain ischemia? | Brain research 20010302 |
| Cytidine (5') diphosphocholine-induced decrease in cerebral platelet activating factor is due to inactivation of its synthesizing enzyme cholinephosphotransferase in aged rats. | Neuroscience letters 20010223 |
| Turnover of phosphatidylcholine in Saccharomyces cerevisiae. The role of the CDP-choline pathway. | The Journal of biological chemistry 20010209 |
| Delayed administration of JTP-2942, a novel thyrotropin-releasing hormone analogue, improves cerebral blood flow and metabolism in rat postischaemic brain. | Clinical and experimental pharmacology & physiology 20010101 |
| Elevated activity of phospholipid biosynthetic enzymes in substantia nigra of patients with Parkinson's disease. | Neuroscience 20010101 |
| Modulation of biosynthesis of phosphatidylcholine via CDP-choline in rat liver: influence of ethanol on the microsomal cholinephosphotransferase activity. | Molecular and cellular biochemistry 20010101 |
| Performance on the Hooper Visual Organizational Test in patients diagnosed with subcortical vascular dementia: relation to naming performance. | Neuropsychiatry, neuropsychology, and behavioral neurology 20010101 |
| CDP-choline, but not cytidine, protects hippocampal CA1 neurones in the gerbil following transient forebrain ischaemia. | Folia neuropathologica 20010101 |
| Short-term treatment with citicoline (CDP-choline) attenuates some measures of craving in cocaine-dependent subjects: a preliminary report. | Psychopharmacology 19990201 |
| A randomized dose-response trial of citicoline in acute ischemic stroke patients. Citicoline Stroke Study Group. | Neurology 19970901 |
| Characterization of 2',3'-dideoxycytidine diphosphocholine and 2',3'-dideoxycytidine diphosphoethanolamine. Prominent phosphodiester metabolites of the anti-HIV nucleoside 2',3'-dideoxycytidine. | Drug metabolism and disposition: the biological fate of chemicals 19930101 |
| Effects of citicholine and of the combination citicholine + piracetam on the memory (experiments on mice). | Acta physiologica et pharmacologica Bulgarica 19900101 |
| Memory effects of the new derivative of the p-chlorophenoxyacetic acid adafenoxate compared to the effects of some cognition-enhancing drugs in rats. | Arzneimittel-Forschung 19890901 |
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