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Home > Nitro Compounds > 3376-24-7
3376-24-7 | N-TERT-BUTYL-ALPHA-PHENYLNITRONE
CAS No: 3376-24-7 Catalog No: AG003TD7 MDL No:MFCD00008799
Product Description
Catalog Number:
AG003TD7
Chemical Name:
N-TERT-BUTYL-ALPHA-PHENYLNITRONE
CAS Number:
3376-24-7
MDL Number:
MFCD00008799
IUPAC Name:
N-tert-butyl-1-phenylmethanimine oxide
InChI:
InChI=1S/C11H15NO/c1-11(2,3)12(13)9-10-7-5-4-6-8-10/h4-9H,1-3H3/b12-9-
InChI Key:
IYSYLWYGCWTJSG-XFXZXTDPSA-N
EC Number:
222-168-6
Properties
Complexity:
185
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
1
Exact Mass:
177.115g/mol
Formal Charge:
0
Heavy Atom Count:
13
Hydrogen Bond Acceptor Count:
1
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
177.247g/mol
Monoisotopic Mass:
177.115g/mol
Rotatable Bond Count:
2
Topological Polar Surface Area:
28.8A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.3
Literature
| Title | Journal |
|---|---|
| Enhanced NADPH oxidases and reactive oxygen species in the mechanism of methanol-initiated protein oxidation and embryopathies in vivo and in embryo culture. | Archives of toxicology 20160301 |
| Deficient DNA repair exacerbates ethanol-initiated DNA oxidation and embryopathies in ogg1 knockout mice: gender risk and protection by a free radical spin trapping agent. | Archives of toxicology 20160201 |
| Complement component 3 inhibition by an antioxidant is neuroprotective after cerebral ischemia and reperfusion in mice. | Journal of neurochemistry 20130201 |
| Reactive oxygen species (ROS) modulate AMPA receptor phosphorylation and cell-surface localization in concert with pain-related behavior. | Pain 20120901 |
| Inhibition of ROS-induced apoptosis in endothelial cells by nitrone spin traps via induction of phase II enzymes and suppression of mitochondria-dependent pro-apoptotic signaling. | Biochemical pharmacology 20120815 |
| 2-Benzazepine nitrones protect dopaminergic neurons against 6-hydroxydopamine-induced oxidative toxicity. | Archiv der Pharmazie 20120801 |
| Synthesis of tris-hydroxymethyl-based nitrone derivatives with highly reactive nitronyl carbon. | The Journal of organic chemistry 20120120 |
| Α-aryl-N-alkyl nitrones, as potential agents for stroke treatment: synthesis, theoretical calculations, antioxidant, anti-inflammatory, neuroprotective, and brain-blood barrier permeability properties. | Journal of medicinal chemistry 20120112 |
| Up-regulation of NF-kB-sensitive miRNA-125b and miRNA-146a in metal sulfate-stressed human astroglial (HAG) primary cell cultures. | Journal of inorganic biochemistry 20111101 |
| Alpha-phenyl-N-tert-butylnitrone (PBN) prevents light-induced degeneration of the retina by inhibiting RPE65 protein isomerohydrolase activity. | The Journal of biological chemistry 20110916 |
| Alpha-phenyl-N-tert-butylnitrone prevents oxidative stress in a haloperidol-induced animal model of tardive dyskinesia: investigating the behavioural and biochemical changes. | Brain research 20110915 |
| Na-K-Cl cotransporter-1 in the mechanism of cell swelling in cultured astrocytes after fluid percussion injury. | Journal of neurochemistry 20110501 |
| Anti-cancer activity of nitrones and observations on mechanism of action. | Anti-cancer agents in medicinal chemistry 20110501 |
| Reactive oxygen species contribute to neuropathic pain by reducing spinal GABA release. | Pain 20110401 |
| The effect of normoxia and hypoxia on a prostate (PC-3) CD44/CD41 cell side fraction. | Anticancer research 20110201 |
| Synthesis, structure, theoretical and experimental in vitro antioxidant/pharmacological properties of α-aryl, N-alkyl nitrones, as potential agents for the treatment of cerebral ischemia. | Bioorganic & medicinal chemistry 20110115 |
| Global inhibition of reactive oxygen species (ROS) inhibits paclitaxel-induced painful peripheral neuropathy. | PloS one 20110101 |
| Cholesterol-based α-phenyl-N-tert-butyl nitrone derivatives as antioxidants against light-induced retinal degeneration. | Bioorganic & medicinal chemistry letters 20101215 |
| Antioxidants have a rapid and long-lasting effect on neuritic abnormalities in APP:PS1 mice. | Neurobiology of aging 20101201 |
| Determining radical penetration into membranes using ESR splitting constants. | Free radical biology & medicine 20100801 |
| Sedentary aging increases resting and exercise-induced intramuscular free radical formation. | Journal of applied physiology (Bethesda, Md. : 1985) 20100801 |
| Amphiphilic amide nitrones: a new class of protective agents acting as modifiers of mitochondrial metabolism. | Journal of medicinal chemistry 20100708 |
| Interleukin-1beta-induced brain injury and neurobehavioral dysfunctions in juvenile rats can be attenuated by alpha-phenyl-n-tert-butyl-nitrone. | Neuroscience 20100616 |
| Using cyclodextrins to encapsulate oxygen-centered and carbon-centered radical adducts: the case of DMPO, PBN, and MNP spin traps. | The journal of physical chemistry. A 20100603 |
| Phenyl-alpha-tert-butyl-nitrone and benzonidazole treatment controlled the mitochondrial oxidative stress and evolution of cardiomyopathy in chronic chagasic Rats. | Journal of the American College of Cardiology 20100601 |
| Decreased brainstem function following cardiac arrest and resuscitation in aged rat. | Brain research 20100430 |
| Modulation of ethoxyquin genotoxicity by free radical scavengers and DNA damage repair in human lymphocytes. | Toxicology letters 20100315 |
| Calicheamicin γ1(I) and phenyl tert-butyl nitrone (PBN): observation of a kinetic isotope effect by an ESR study. | Chemical communications (Cambridge, England) 20100207 |
| Phenyl N-tert-butylnitrone, a free radical scavenger, reduces mechanical allodynia in chemotherapy-induced neuropathic pain in rats. | Anesthesiology 20100201 |
| New heteroaryl nitrones with spin trap properties: Identification of a 4-furoxanyl derivative with excellent properties to be used in biological systems. | Bioorganic & medicinal chemistry 20100115 |
| Involvement of reactive oxygen species in long-term potentiation in the spinal cord dorsal horn. | Journal of neurophysiology 20100101 |
| Interleukin-1beta-induced brain injury in the neonatal rat can be ameliorated by alpha-phenyl-n-tert-butyl-nitrone. | Experimental neurology 20091101 |
| Manganese inhibits the ability of astrocytes to promote neuronal differentiation. | Toxicology and applied pharmacology 20091015 |
| Protection of DFP-induced oxidative damage and neurodegeneration by antioxidants and NMDA receptor antagonist. | Toxicology and applied pharmacology 20091015 |
| Functional consequences of mitochondrial DNA deletions in human skin fibroblasts: increased contractile strength in collagen lattices is due to oxidative stress-induced lysyl oxidase activity. | The American journal of pathology 20090901 |
| Preparation and evaluation of alpha-phenyl-n-tert-butyl nitrone (PBN)-encapsulated chitosan and PEGylated chitosan nanoparticles. | Die Pharmazie 20090701 |
| The effect of exercise and oxidant-antioxidant intervention on the levels of neurotrophins and free radicals in spinal cord of rats. | Spinal cord 20090601 |
| Matrix metalloproteinase inhibition reduces oxidative stress associated with cerebral amyloid angiopathy in vivo in transgenic mice. | Journal of neurochemistry 20090601 |
| Serendipitous findings while researching oxygen free radicals. | Free radical biology & medicine 20090415 |
| Antioxidant effect of ethyl pyruvate in respiring neonatal cerebrocortical slices after H(2)O(2) stress. | Neurochemistry international 20090201 |
| Persistent pain is dependent on spinal mitochondrial antioxidant levels. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20090107 |
| Reactive oxygen species mediate TNFR1 increase after TRPV1 activation in mouse DRG neurons. | Molecular pain 20090101 |
| Increased production of mitochondrial superoxide in the spinal cord induces pain behaviors in mice: the effect of mitochondrial electron transport complex inhibitors. | Neuroscience letters 20081205 |
| Reactivity of superoxide radical anion and hydroperoxyl radical with alpha-phenyl-N-tert-butylnitrone (PBN) derivatives. | The journal of physical chemistry. A 20081204 |
| Heteroarylnitrones as drugs for neurodegenerative diseases: synthesis, neuroprotective properties, and free radical scavenger properties. | Journal of medicinal chemistry 20081009 |
| Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice. | Aging cell 20081001 |
| Luminal antioxidants enhance the effects of mesalamine in the treatment of chemically induced colitis in rats. | Experimental biology and medicine (Maywood, N.J.) 20081001 |
| Antioxidative and thrombolytic TMP nitrone for treatment of ischemic stroke. | Bioorganic & medicinal chemistry 20081001 |
| Oxidative stress in the spinal cord is an important contributor in capsaicin-induced mechanical secondary hyperalgesia in mice. | Pain 20080915 |
| Enhanced anodic Ru(bpy)3(2+) electrogenerated chemiluminescence by polyphenols. | Analytica chimica acta 20080905 |
| Assessment of genotoxicity of methyl-tert-butyl ether, benzene, toluene, ethylbenzene, and xylene to human lymphocytes using comet assay. | Journal of hazardous materials 20080501 |
| 1Alpha,25-dihydroxyvitamin D3 attenuates cyanide-induced neurotoxicity by inhibiting uncoupling protein-2 up-regulation. | Journal of neuroscience research 20080501 |
| Reactive oxygen species contribute to lipopolysaccharide-induced teratogenesis in mice. | Toxicological sciences : an official journal of the Society of Toxicology 20080501 |
| Effectiveness of 4-hydroxy phenyl N-tert-butylnitrone (4-OHPBN) alone and in combination with other antioxidant drugs in the treatment of acute acoustic trauma in chinchilla. | Free radical biology & medicine 20080501 |
| Mechanistic studies of the reactions of nitrone spin trap PBN with glutathiyl radical. | The journal of physical chemistry. B 20080417 |
| In vitro electron paramagnetic resonance characterization of free radicals: relevance to exercise-induced lipid peroxidation and implications of ascorbate prophylaxis. | Free radical research 20080401 |
| Alpha-phenyl-n-tert-butyl-nitrone ameliorates hippocampal injury and improves learning and memory in juvenile rats following neonatal exposure to lipopolysaccharide. | The European journal of neuroscience 20080301 |
| [Preparation of the spin trapping probe, N-tert-butyl-alpha-phenylnitrone, nanoparticle and its affinity to hepatoma cells]. | Yao xue xue bao = Acta pharmaceutica Sinica 20080301 |
| alpha-Phenyl-n-tert-butyl-nitrone reduces lipopolysaccharide-induced white matter injury in the neonatal rat brain. | Developmental neurobiology 20080215 |
| Maternally administered lipopolysaccharide (LPS) upregulates the expression of heme oxygenase-1 in fetal liver: the role of reactive oxygen species. | Toxicology letters 20080215 |
| Alpha-Phenyl-n-tert-butyl-nitrone attenuates lipopolysaccharide-induced neuronal injury in the neonatal rat brain. | Neuroscience 20080206 |
| Metal sulfate-mediated induction of pathogenic genes and repression by phenyl butyl nitrone and Feralex-G. | Neuroreport 20080122 |
| Phenyl-tert-butylnitrone induces tumor regression and decreases angiogenesis in a C6 rat glioma model. | Free radical biology & medicine 20080101 |
| Pharmacological interventions to decompression sickness in rats: comparison of five agents. | Aviation, space, and environmental medicine 20080101 |
| Mitochondrial dysfunction in aging rat brain following transient global ischemia. | Advances in experimental medicine and biology 20080101 |
| The role of reactive oxygen species in capsaicin-induced mechanical hyperalgesia and in the activities of dorsal horn neurons. | Pain 20071215 |
| Synergism in the repression of COX-2- and TNFalpha-induction in platelet activating factor-stressed human neural cells. | Neuroscience letters 20071009 |
| Reactive oxygen species (ROS) are involved in enhancement of NMDA-receptor phosphorylation in animal models of pain. | Pain 20071001 |
| Exogenous ethyl pyruvate versus pyruvate during metabolic recovery after oxidative stress in neonatal rat cerebrocortical slices. | Anesthesiology 20071001 |
| Modulation of Fas-FasL related apoptosis by PBN in the early phases of choline deficient diet-mediated hepatocarcinogenesis in rats. | Free radical research 20070901 |
| Investigating the free radical trapping ability of NXY-059, S-PBN and PBN. | Free radical research 20070901 |
| A new amphiphilic derivative, N-{[4-(lactobionamido)methyl]benzylidene}-1,1-dimethyl-2-(octylsulfanyl)ethylamine N-oxide, has a protective effect against copper-induced fulminant hepatitis in Long-Evans Cinnamon rats at an extremely low concentration compared with its original form alpha-phenyl-N-(tert-butyl) nitrone. | Chemistry & biodiversity 20070901 |
| Fine-tuning the amphiphilicity: a crucial parameter in the design of potent alpha-phenyl-N-tert-butylnitrone analogues. | Journal of medicinal chemistry 20070823 |
| An Aging Interventions Testing Program: study design and interim report. | Aging cell 20070801 |
| Alpha-phenyl-N-tert-butyl nitrone (PBN) derivatives: synthesis and protective action against microvascular damages induced by ischemia/reperfusion. | Bioorganic & medicinal chemistry 20070515 |
| Involvement of oxidants and AP-1 in angiotensin II-activated NFAT3 transcription factor. | American journal of physiology. Cell physiology 20070401 |
| Aryl radical involvement in amiodarone-induced pulmonary toxicity: investigation of protection by spin-trapping nitrones. | Toxicology and applied pharmacology 20070401 |
| Delayed loss of cone and remaining rod photoreceptor cells due to impairment of choroidal circulation after acute light exposure in rats. | Investigative ophthalmology & visual science 20070401 |
| Release of secondary free radicals during post-ischaemic reperfusion is not influenced by extracellular calcium levels in isolated rat hearts. | Molecular and cellular biochemistry 20070301 |
| Bioaccumulation and ROS generation in liver of Carassius auratus, exposed to phenanthrene. | Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20070301 |
| Electron paramagnetic spectroscopic evidence of exercise-induced free radical accumulation in human skeletal muscle. | Free radical research 20070201 |
| Antioxidants attenuate MK-801-induced cortical neurotoxicity in the rat. | Neurotoxicology 20070101 |
| Gene expression in enhanced apoptosis of human lymphoma U937 cells treated with the combination of different free radical generators and hyperthermia. | Free radical research 20070101 |
| Increased sensitivity to transient global ischemia in aging rat brain. | Advances in experimental medicine and biology 20070101 |
| Alpha-phenyl-N-tert-butylnitrone-type derivatives bound to beta-cyclodextrins: syntheses, thermokinetics of self-inclusion and application to superoxide spin-trapping. | Chemistry (Weinheim an der Bergstrasse, Germany) 20070101 |
| Reactive oxygen species are involved in lipopolysaccharide-induced intrauterine growth restriction and skeletal development retardation in mice. | American journal of obstetrics and gynecology 20061201 |
| Phenyl-alpha-tert-butyl nitrone reverses mitochondrial decay in acute Chagas' disease. | The American journal of pathology 20061201 |
| Spin-trapping of the p-benzyne intermediates from ten-membered enediyne calicheamicin gamma1I. | Organic letters 20061123 |
| Antioxidants attenuate multiple phases of formalin-induced nociceptive response in mice. | Behavioural brain research 20061016 |
| Trimethyltin-induced apoptosis is associated with upregulation of inducible nitric oxide synthase and Bax in a hippocampal cell line. | Toxicology and applied pharmacology 20061001 |
| Neuroprotection of alpha-phenyl-n-tert-butyl-nitrone on the neonatal white matter is associated with anti-inflammation. | Neuroscience letters 20060911 |
| Ferritin levels in microglia depend upon activation: modulation by reactive oxygen species. | Biochimica et biophysica acta 20060801 |
| Measurement of myocardial free radical production during exercise using EPR spectroscopy. | American journal of physiology. Heart and circulatory physiology 20060601 |
| Alpha-tocopherol amplifies benzoyl peroxide free radical decomposition in a chemical system. | Free radical research 20060601 |
| Fluorinated amphiphilic amino acid derivatives as antioxidant carriers: a new class of protective agents. | Journal of medicinal chemistry 20060504 |
| High static pressure alters spin trapping rates in solution. Dependence on the structure of nitrone spin traps. | Organic & biomolecular chemistry 20060307 |
| Effects of alpha-phenyl-N-tert-butyl nitrone and N-acetylcysteine on hydroxyl radical formation and dopamine depletion in the rat striatum produced by d-amphetamine. | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20060201 |
| Enhancement of apoptosis by nitric oxide released from alpha-phenyl-tert-butyl nitrone under hyperthermic conditions. | Journal of cellular physiology 20060201 |
| LPS-induced ROS generation and changes in glutathione level and their relation to the maturation of human monocyte-derived dendritic cells. | Life sciences 20060125 |
| Differential nephron HO-1 expression following glomerular epithelial cell injury. | Nephron. Experimental nephrology 20060101 |
| Comparison of neuroprotective effects induced by alpha-phenyl-N-tert-butyl nitrone (PBN) and N-tert-butyl-alpha-(2 sulfophenyl) nitrone (S-PBN) in lithium-pilocarpine status epilepticus. | Neurotoxicology 20051201 |
| The effect of alpha-phenyl-N-t-butylnitrone on ionizing radiation-induced apoptosis in U937 cells. | Free radical research 20051201 |
| Delay of photoreceptor cell degeneration in rd mice by systemically administered phenyl-N-tert-butylnitrone. | Korean journal of ophthalmology : KJO 20051201 |
| Experimental treatment for focal hyperglycemic ischemic brain injury in the rat. | Experimental brain research 20051101 |
| Protein modifications by 4-hydroxynonenal and 4-hydroxyhexenal in light-exposed rat retina. | Investigative ophthalmology & visual science 20051001 |
| Electron paramagnetic resonance evidence of hydroxyl radical generation and oxidative damage induced by tetrabromobisphenol A in Carassius auratus. | Aquatic toxicology (Amsterdam, Netherlands) 20050930 |
| Free radical generation during chemical depolymerization of heparin. | Analytical biochemistry 20050915 |
| Perinatal lipopolysaccharide exposure downregulates pregnane X receptor and Cyp3a11 expression in fetal mouse liver. | Toxicological sciences : an official journal of the Society of Toxicology 20050901 |
| Electron paramagnetic resonance investigation of in vivo free radical formation and oxidative stress induced by 2,4-dichlorophenol in the freshwater fish Carassius auratus. | Environmental toxicology and chemistry 20050901 |
| Oxygen radicals photo-induced by ferric nitrilotriacetate complex. | Biochimica et biophysica acta 20050830 |
| Antioxidant pool in beer and kinetics of EPR spin-trapping. | Journal of agricultural and food chemistry 20050824 |
| Lipopolysaccharide treatment downregulates the expression of the pregnane X receptor, cyp3a11 and mdr1a genes in mouse placenta. | Toxicology 20050801 |
| ESR spin trapping of a carbon-centered free radical from agonist-stimulated human platelets. | Free radical biology & medicine 20050715 |
| Correlation of hippocampal morphological changes and morris water maze performance after cortical contusion injury in rats. | Neurosurgery 20050701 |
| Nitrone derivatives of trolox as neuroprotective agents. | Bioorganic & medicinal chemistry letters 20050615 |
| Study of the oxidative stress in a rat model of chronic brain hypoperfusion. | Neurochemistry international 20050601 |
| Budesonide epimer R, LAU-8080 and phenyl butyl nitrone synergistically repress cyclooxygenase-2 induction in [IL-1beta+Abeta42]-stressed human neural cells. | Neuroscience letters 20050501 |
| Donepezil, tacrine and alpha-phenyl-n-tert-butyl nitrone (PBN) inhibit choline transport by conditionally immortalized rat brain capillary endothelial cell lines (TR-BBB). | Archives of pharmacal research 20050401 |
| Electron spin resonance spin trapping for analysis of lipid oxidation in oils: inhibiting effect of the spin trap alpha-phenyl-N-tert-butylnitrone on lipid oxidation. | Journal of agricultural and food chemistry 20050309 |
| Analysis of gene expression in apoptosis of human lymphoma U937 cells induced by heat shock and the effects of alpha-phenyl N-tert-butylnitrone (PBN) and its derivatives. | Apoptosis : an international journal on programmed cell death 20050301 |
| Nitric oxide produced by inducible nitric oxide synthase is associated with mammary tumorigenesis in irradiated rats. | Nitric oxide : biology and chemistry 20050201 |
| Time course of oxidative stress, lesion and edema after intrastriatal injection of malonate in rat: effect of alpha-phenyl-N-tert-butylnitrone. | Fundamental & clinical pharmacology 20050201 |
| Mechanism of protection from light-induced retinal degeneration by the synthetic antioxidant phenyl-N-tert-butylnitrone. | Investigative ophthalmology & visual science 20050201 |
| Paradoxical increase in 3-nitropropionic acid neurotoxicity by alpha-phenyl-tert-butyl-nitrone, a spin-trapping agent. | Chang Gung medical journal 20050201 |
| Alpha phenyl-tert-butyl nitrone (PBN) protects syngeneic marrow transplant recipients from the lethal cytokine syndrome occurring after agonistic CD40 antibody administration. | Blood 20050101 |
| Effects of a free radical scavenger N-tert-butyl-alpha-phenylnitrone (PBN) on short-term recovery of immature rats after status epilepticus. | Physiological research 20050101 |
| Vitamin E, aging and Leydig cell steroidogenesis. | Experimental gerontology 20050101 |
| Electron spin resonance spectroscopy reveals alpha-phenyl-N-tert-butylnitrone spin-traps free radicals in rat striatum and prevents haloperidol-induced vacuous chewing movements in the rat model of human tardive dyskinesia. | Synapse (New York, N.Y.) 20041201 |
| Genotoxicity of acrylamide in human lymphocytes. | Chemico-biological interactions 20041015 |
| Electron spin resonance study of phosphorus-nitroxides from 1,3-additions of silicon-phosphorus reagents to nitrones. | Magnetic resonance in chemistry : MRC 20041001 |
| Reactive oxygen species (ROS) play an important role in a rat model of neuropathic pain. | Pain 20040901 |
| Effects of alpha-phenyl-N-tert-butyl nitrone (PBN)on brain cell membrane function and energy metabolism during transient global cerebral hypoxia-ischemia and reoxygenation-reperfusion in newborn piglets. | Journal of Korean medical science 20040601 |
| The role of superoxide dismutase and alpha-tocopherol in the development of seizures and kindling induced by pentylenetetrazol - influence of the radical scavenger alpha-phenyl-N-tert-butyl nitrone. | Brain research 20040529 |
| alpha-Phenyl-n-tert-butyl-nitrone attenuates hypoxic-ischemic white matter injury in the neonatal rat brain. | Brain research 20040508 |
| In vivo monitoring of hydroxyl radical generation caused by x-ray irradiation of rats using the spin trapping/EPR technique. | Free radical biology & medicine 20040501 |
| Inhibition of the development of hepatocellular carcinomas by phenyl N-tert-butyl nitrone in rats fed with a choline-deficient, L-amino acid-defined diet. | Cancer letters 20040331 |
| Protein oxidation and the degradation of oxidized proteins in the rat oligodendrocyte cell line OLN 93-antioxidative effect of the intracellular spin trapping agent PBN. | Brain research. Molecular brain research 20040330 |
| ESR study of spin-trapping with two glycosylated analogues of PBN able to target cell membrane lectins. | Organic & biomolecular chemistry 20040321 |
| Bicarbonate enhances alpha-synuclein oligomerization and nitration: intermediacy of carbonate radical anion and nitrogen dioxide radical. | The Biochemical journal 20040301 |
| A novel hypothesis for thalidomide-induced limb teratogenesis: redox misregulation of the NF-kappaB pathway. | Antioxidants & redox signaling 20040201 |
| [Effect of phenyl-tert-butylnitrone, mexidol and nooglutil on the ischemic lesion zone and memory in rats following middle cerebral artery occlusion]. | Eksperimental'naia i klinicheskaia farmakologiia 20040101 |
| The stability studies and in vitro hepatic microsomal metabolism of some alpha-phenyl-N-substituted nitrones in rats. | European journal of drug metabolism and pharmacokinetics 20040101 |
| Different mechanisms of hypoxic injury on white matter and gray matter as revealed by dynamic changes in glucose metabolism in rats. | Neuroscience letters 20031219 |
| Superoxide activates uncoupling proteins by generating carbon-centered radicals and initiating lipid peroxidation: studies using a mitochondria-targeted spin trap derived from alpha-phenyl-N-tert-butylnitrone. | The Journal of biological chemistry 20031205 |
| Pharmacologic suppression of neuronal oxidative damage and dendritic degeneration following direct activation of glial innate immunity in mouse cerebrum. | Journal of neurochemistry 20031201 |
| Protective effect of phenyl-t-butylnitrone in rats with focal cerebral ischemia. | Bulletin of experimental biology and medicine 20031201 |
| Synthesis and preliminary biological evaluations of ionic and nonionic amphiphilic alpha-phenyl-N-tert-butylnitrone derivatives. | Journal of medicinal chemistry 20031120 |
| Free radical-dependent nuclear localization of Bcl-2 in the central nervous system of aged rats is not associated with Bcl-2-mediated protection from apoptosis. | Journal of neurochemistry 20031101 |
| The effects of PBN (phenyl-butyl-nitrone) on GLT-1 levels and on the extracellular levels of amino acids and energy metabolites in a model of iron-induced posttraumatic epilepsy. | Epilepsy research 20031001 |
| Optimizing electron spin resonance detection of hydroxyl radical in water. | Chemosphere 20030901 |
| Synthesis and antioxidant efficiency of a new amphiphilic spin-trap derived from PBN and lipoic acid. | Bioorganic & medicinal chemistry letters 20030818 |
| Effect of two new PBN-derived phosphorylated nitrones against postischaemic ventricular dysrhythmias. | Fundamental & clinical pharmacology 20030801 |
| Nitric oxide counteracts the senescence of rice leaves induced by abscisic acid. | Journal of plant physiology 20030801 |
| Free radical trap phenyl-N-tert-butylnitrone protects against light damage but does not rescue P23H and S334ter rhodopsin transgenic rats from inherited retinal degeneration. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20030709 |
| An inducible nitric oxide synthase-luciferase reporter system for in vivo testing of anti-inflammatory compounds in transgenic mice. | Journal of immunology (Baltimore, Md. : 1950) 20030615 |
| Rapid reduction of ATP synthesis and lack of free radical formation by MPP+ in rat brain synaptosomes and mitochondria. | Brain research 20030613 |
| Ischemia and reperfusion of skeletal muscle lead to the appearance of a stable lipid free radical in the circulation. | American journal of physiology. Heart and circulatory physiology 20030601 |
| EPR spectroscopic detection of free radical outflow from an isolated muscle bed in exercising humans. | Journal of applied physiology (Bethesda, Md. : 1985) 20030501 |
| In vivo imaging of reactive oxygen species specifically associated with thioflavine S-positive amyloid plaques by multiphoton microscopy. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20030315 |
| In vitro genotoxicity of lead acetate: induction of single and double DNA strand breaks and DNA-protein cross-links. | Mutation research 20030303 |
| Antioxidant amplifies antibiotic protection in the cecal ligation and puncture model of microbial sepsis through interleukin-10 production. | Shock (Augusta, Ga.) 20030301 |
| Free radical scavengers can differentially modulate the genotoxicity of amsacrine in normal and cancer cells. | Mutation research 20030205 |
| Pharmacokinetics and metabolism of the reactive oxygen scavenger alpha-phenyl-N-tert-butylnitrone in the male Sprague-Dawley rat. | Drug metabolism and disposition: the biological fate of chemicals 20030201 |
| Methylmercury-induced reactive oxygen species formation in neonatal cerebral astrocytic cultures is attenuated by antioxidants. | Brain research. Molecular brain research 20030131 |
| Cocaine treatment increases expression of a 40 kDa catecholamine-regulated protein in discrete brain regions. | Synapse (New York, N.Y.) 20030101 |
| Effects of phenyl N-tert-butyl nitrone and its derivatives on the early phase of hepatocarcinogenesis in rats fed a choline-deficient, L-amino acid-defined diet. | Cancer science 20030101 |
| In vitro neuroprotection against oxidative stress by pre-treatment with a combination of dihydrolipoic acid and phenyl-butyl nitrones. | Neurotoxicity research 20030101 |
| Maternal treatment with alpha-phenyl-N-tert-butylnitrone attenuates secondary mitochondrial dysfunction after transient intrauterine asphyxia in the fetal rat brain. | Gynecologic and obstetric investigation 20030101 |
| Involvement of nitric oxide in kainic acid-induced excitotoxicity in rat brain. | Brain research 20021213 |
| Lipid peroxidation-mediated cytotoxicity and DNA damage in U937 cells. | Biochimie 20021201 |
| Windows of therapeutic opportunity on fetal growth retardation induced by transient intrauterine ischemia in rats. | Journal of Nippon Medical School = Nippon Ika Daigaku zasshi 20021201 |
| Antioxidant balance and free radical generation in vitamin e-deficient mice after dermal exposure to cumene hydroperoxide. | Chemical research in toxicology 20021101 |
| Misregulation of gene expression in the redox-sensitive NF-kappab-dependent limb outgrowth pathway by thalidomide. | Developmental dynamics : an official publication of the American Association of Anatomists 20021001 |
| Inactivation of the 2-oxo acid dehydrogenase complexes upon generation of intrinsic radical species. | European journal of biochemistry 20021001 |
| Effect of traumatic brain injury and nitrone radical scavengers on relative changes in regional cerebral blood flow and glucose uptake in rats. | Journal of neurotrauma 20021001 |
| ESR characterization of a novel spin-trapping agent, 15N-labeled N-tert-butyl-alpha-phenylnitrone, as a nitric oxide donor. | Bioscience, biotechnology, and biochemistry 20021001 |
| Assessment of neuroprotective ability of a spin trap, alpha-phenyl-N-tert-butylnitrone, against malonate-induced ischemic injury of rat brain by apparent water diffusion coefficient mapping. | Neuroscience letters 20020906 |
| Analysis of tert-butyl hydroperoxide induced constrictions of perfused vascular beds in vitro. | Life sciences 20020802 |
| Region-selective effects of neuroinflammation and antioxidant treatment on peripheral benzodiazepine receptors and NMDA receptors in the rat brain. | Journal of neurochemistry 20020801 |
| Cerebral vasculature is the major target of oxidative protein alterations in bacterial meningitis. | Journal of neuropathology and experimental neurology 20020701 |
| The spin trapping agent PBN stimulates H2 O2 -induced Erk and Src kinase activity in human neuroblastoma cells. | Neuroreport 20020612 |
| Embryonic arrhythmia by inhibition of HERG channels: a common hypoxia-related teratogenic mechanism for antiepileptic drugs? | Epilepsia 20020501 |
| Nitrones, their value as therapeutics and probes to understand aging. | Mechanisms of ageing and development 20020430 |
| Differential ototoxicities induced by lead acetate and tetraethyl lead. | Hearing research 20020401 |
| The neuroprotective activities of melatonin against the Alzheimer beta-protein are not mediated by melatonin membrane receptors. | Journal of pineal research 20020401 |
| The nitrone spin trap PBN alters the cellular response to H(2)O(2): activation of the EGF receptor/ERK pathway. | Free radical biology & medicine 20020315 |
| Effects of adenosine pretreatment on detection of free radicals in ischemic and reperfused canine gracilis muscle flaps by use of spin-trapping electron paramagnetic resonance spectroscopy. | American journal of veterinary research 20020201 |
| alpha-Phenyl-N-tert-butylnitrone provides protection from dextran sulfate sodium-induced colitis in mice. | Antioxidants & redox signaling 20020201 |
| Amyloid-beta-protein (A beta) (25-35)-associated free radical generation is strongly influenced by the aggregational state of the peptides. | Life sciences 20020104 |
| Prevention of radiation-induced mammary tumors. | International journal of radiation oncology, biology, physics 20020101 |
| Combined antibiotic and free radical trap treatment is effective at combating Staphylococcus-aureus-induced septic arthritis. | Arthritis research 20020101 |
| Reactive oxygen species in choline deficiency induced carcinogenesis and nitrone inhibition. | Molecular and cellular biochemistry 20020101 |
| DNA damage in human colonic mucosa cells evoked by nickel and protective action of quercetin - involvement of free radicals? | Cell biology and toxicology 20020101 |
| Multiple pathways of neuroprotection against oxidative stress and excitotoxic injury in immature primary hippocampal neurons. | Brain research. Developmental brain research 20011231 |
| Early effects on restoration of evoked field potentials in the hippocampal CA(1) region after reversible hypoxia/hypoglycemia by the radical scavenger N-tert.-butyl-alpha-phenylnitron. | Brain research 20011213 |
| A study of the mechanisms involved in the neurotoxic action of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') on dopamine neurones in mouse brain. | British journal of pharmacology 20011201 |
| Reactive oxygen species mediate pyridostigmine-induced neuronal apoptosis: involvement of muscarinic and NMDA receptors. | Toxicology and applied pharmacology 20011115 |
| Effects of the nitrone radical scavengers PBN and S-PBN on in vivo trapping of reactive oxygen species after traumatic brain injury in rats. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20011101 |
| Direct administration of interleukin-1 and interferon-gamma to rat pancreas leads to the in vivo production of nitric oxide and expression of inducible nitric oxide synthase and inducible cyclooxygenase. | Pancreas 20011001 |
| Changes in reactive oxygen species (ROS) production in rat brain during global perinatal asphyxia: an ESR study. | Brain research 20010928 |
| Oxidative stress in brain during experimental bacterial meningitis: differential effects of alpha-phenyl-tert-butyl nitrone and N-acetylcysteine treatment. | Free radical biology & medicine 20010915 |
| In vitro ischemia-reperfusion injury in term human placenta as a model for oxidative stress in pathological pregnancies. | The American journal of pathology 20010901 |
| Induction of neurite outgrowth in PC12 cells by alpha -phenyl-N-tert-butylnitron through activation of protein kinase C and the Ras-extracellular signal-regulated kinase pathway. | The Journal of biological chemistry 20010831 |
| Alterations in cytochrome c oxidase activity and energy metabolites in response to kainic acid-induced status epilepticus. | Brain research 20010831 |
| Free radical scavenger posttreatment improves functional and morphological outcome after fluid percussion injury in the rat. | Journal of neurotrauma 20010801 |
| Nitric oxide modulates high-energy phosphates in brain regions of rats intoxicated with diisopropylphosphorofluoridate or carbofuran: prevention by N-tert-butyl-alpha-phenylnitrone or vitamin E. | Archives of toxicology 20010801 |
| Evidence for isoniazid-dependent free radical generation catalyzed by Mycobacterium tuberculosis KatG and the isoniazid-resistant mutant KatG(S315T). | Biochemistry 20010731 |
| N-tert-butyl-alpha-phenylnitrone, a free radical scavenger with anticholinesterase activity does not improve the cognitive performance of scopolamine-challenged rats. | International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20010601 |
| Methylmercury-mediated inhibition of 3H-D-aspartate transport in cultured astrocytes is reversed by the antioxidant catalase. | Brain research 20010525 |
| p38 activation is required upstream of potassium current enhancement and caspase cleavage in thiol oxidant-induced neuronal apoptosis. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20010515 |
| Strategies for neuroprotection against L-trans-2,4-pyrrolidine dicarboxylate-induced neuronal damage during energy impairment in vitro. | Journal of neuroscience research 20010515 |
| Marked elevation in cortical urate and xanthine oxidoreductase activity in experimental bacterial meningitis. | Brain research 20010511 |
| Systemic administration of phenyl-N-tert-butylnitrone protects the retina from light damage. | Investigative ophthalmology & visual science 20010501 |
| Bioactivation and cytotoxicity of 1,1-dichloro-2,2,2-trifluoroethane (HCFC-123) in isolated rat hepatocytes. | Pharmacology & toxicology 20010401 |
| Comparison of the radical trapping ability of PBN, S-PPBN and NXY-059. | Free radical research 20010401 |
| Depletion of energy metabolites following acetylcholinesterase inhibitor-induced status epilepticus: protection by antioxidants. | Neurotoxicology 20010401 |
| Developmental changes in tolerance to transient intrauterine ischemia in rat cerebral mitochondria. | American journal of obstetrics and gynecology 20010301 |
| Oxidative-stress-dependent up-regulation of Bcl-2 expression in the central nervous system of aged Fisher-344 rats. | Journal of neurochemistry 20010201 |
| The free radical scavenger alpha-phenyl-tert-butyl nitrone aggravates hippocampal apoptosis and learning deficits in experimental pneumococcal meningitis. | The Journal of infectious diseases 20010115 |
| Pharmacological effects of the spin trap agents N-t-butyl-phenylnitrone (PBN) and 2,2,6, 6-tetramethylpiperidine-N-oxyl (TEMPO) in a rabbit thromboembolic stroke model: combination studies with the thrombolytic tissue plasminogen activator. | Stroke 20010101 |
| alpha-Phenyl-tert-N-butyl nitrone (PBN) improves functional and morphological outcome after cortical contusion injury in the rat. | Acta neurochirurgica 20010101 |
| The heme oxygenase system and cellular defense mechanisms. Do HO-1 and HO-2 have different functions? | Advances in experimental medicine and biology 20010101 |
| Evaluation of the effects of alpha-phenyl-N-tert-butyl nitrone pretreatment on the neurobehavioral effects of methamphetamine. | Life sciences 20000818 |
| Spin trapping agent phenyl-N-tert-butylnitrone prevents diisopropylphosphorofluoridate-induced excitotoxicity in skeletal muscle of the rat. | Neuroscience letters 20000107 |
| Reductive activation of 1,1-dichloro-1-fluoroethane (HCFC-141b) by phenobarbital- and pyridine-induced rat liver microsomal cytochrome P450. | Xenobiotica; the fate of foreign compounds in biological systems 19960401 |
| Role of oxygen free radicals in cocaine-induced vascular disruption in mice. | Teratology 19940301 |
| Protective effects of spin-trapping agents on adriamycin-induced cardiotoxicity in isolated rat atria. | Free radical research communications 19910101 |
| Halothane-induced liver injury as a consequence of enhanced microsomal lipid peroxidation in guinea pigs. | Research communications in chemical pathology and pharmacology 19880801 |
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