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Home > Other Heterocycles > 33386-08-2

33386-08-2

33386-08-2 | Buspirone Hydrochloride

CAS No: 33386-08-2 Catalog No: AG01A3K0 MDL No:MFCD00078569

Product Description

Catalog Number:
AG01A3K0
Chemical Name:
Buspirone Hydrochloride
CAS Number:
33386-08-2
Molecular Formula:
C21H32ClN5O2
Molecular Weight:
421.9641
MDL Number:
MFCD00078569
IUPAC Name:
8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione;hydrochloride
InChI:
InChI=1S/C21H31N5O2.ClH/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20;/h5,8-9H,1-4,6-7,10-17H2;1H
InChI Key:
RICLFGYGYQXUFH-UHFFFAOYSA-N
SMILES:
O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1.Cl
EC Number:
251-489-4
UNII:
207LT9J9OC

Properties

Complexity:
529  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
421.224g/mol
Formal Charge:
0
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
421.97g/mol
Monoisotopic Mass:
421.224g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
69.6A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0

Literature

Title Journal
Dopamine D3 receptor is necessary for ethanol consumption: an approach with buspirone. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20140701
An exploratory study of combination buspirone and melatonin SR in major depressive disorder (MDD): a possible role for neurogenesis in drug discovery. Journal of psychiatric research 20121201
Intravenous buspirone for the prevention of postoperative nausea and vomiting. European journal of clinical pharmacology 20121101
The 5-HT1A-receptor agonist flibanserin reduces drug-induced dyskinesia in RGS9-deficient mice. Journal of neural transmission (Vienna, Austria : 1996) 20121101
Efficacy of buspirone, a fundus-relaxing drug, in patients with functional dyspepsia. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20121101
Performance in anxiety and spatial memory tests following bilateral vestibular loss in the rat and effects of anxiolytic and anxiogenic drugs. Behavioural brain research 20121101
Probable drug-drug interaction leading to serotonin syndrome in a patient treated with concomitant buspirone and linezolid in the setting of therapeutic hypothermia. Journal of clinical pharmacy and therapeutics 20121001
The immediate and the delayed effects of buspirone on zebrafish (Danio rerio) in an open field test: a 3-D approach. Behavioural brain research 20121001
Buspirone blocks the enhancing effect of the anxiogenic drug RS 79948-197 on consolidation of habit memory. Behavioural brain research 20121001
Anxiolytic effects of yokukansan, a traditional Japanese medicine, via serotonin 5-HT1A receptors on anxiety-related behaviors in rats experienced aversive stress. Journal of ethnopharmacology 20120928
Serotonergic and dopaminergic mechanisms in graft-induced dyskinesia in a rat model of Parkinson's disease. Neurobiology of disease 20120901
Evaluation of buspirone for relapse-prevention in adults with cocaine dependence: an efficacy trial conducted in the real world. Contemporary clinical trials 20120901
Application of a sensitive and specific LC-MS/MS method for determination of chinensinaphthol methyl ether in rat plasma for a bioavailability study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120815
Two weeks of buspirone protects against posthypoxic ventilatory pauses in the C57BL/6J mouse strain. Respiratory physiology & neurobiology 20120731
Effect of buspirone, a 5-HT1A receptor agonist, on esophageal motility in healthy volunteers. Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus 20120701
Traumatic brain injury-induced cognitive and histological deficits are attenuated by delayed and chronic treatment with the 5-HT1A-receptor agonist buspirone. Journal of neurotrauma 20120701
Evaluation of a combined treatment paradigm consisting of environmental enrichment and the 5-HT1A receptor agonist buspirone after experimental traumatic brain injury. Journal of neurotrauma 20120701
Decision time and perseveration of adolescent rats in the T-maze are affected differentially by buspirone and independent of 5-HT-1A expression. Pharmacology, biochemistry, and behavior 20120701
A semi-automated method for the integrated evaluation of half-life and metabolic soft spots of discovery compounds. Bioanalysis 20120701
Buspirone: what is it all about? Brain research 20120621
Mechanism-based pharmacokinetic/pharmacodynamic modeling of rat prefrontal cortical dopamine response to dual acting norepinephrine reuptake inhibitor and 5-HT1A partial agonist. The AAPS journal 20120601
Determinants of effective cooling during endovascular hypothermia. Neurocritical care 20120601
Reversal of cocaine withdrawal-induced anxiety by ondansetron, buspirone and propranolol. Behavioural brain research 20120516
Functional and physiological effects of treadmill training induced by buspirone, carbidopa, and L-DOPA in clenbuterol-treated paraplegic mice. Neurorehabilitation and neural repair 20120501
Outcomes on the pharmacopsychometric triangle in bupropion-SR vs. buspirone augmentation of citalopram in the STAR*D trial. Acta psychiatrica Scandinavica 20120401
An 8-week, randomized controlled trial of atomoxetine, atomoxetine plus buspirone, or placebo in adults with ADHD. The Journal of clinical psychiatry 20120401
Synthesis, in vitro binding studies and docking of long-chain arylpiperazine nitroquipazine analogues, as potential serotonin transporter inhibitors. European journal of medicinal chemistry 20120301
Use of buspirone and fluoxetine for breathing problems in Rett syndrome. Pediatric neurology 20120301
Treating depression after initial treatment failure: directly comparing switch and augmenting strategies in STAR*D. Journal of clinical psychopharmacology 20120201
Paroxetine-induced severe sleep bruxism successfully treated with buspirone. Clinics (Sao Paulo, Brazil) 20120201
Quantitative analysis of atractylenolide I in rat plasma by LC-MS/MS method and its application to pharmacokinetic study. Journal of pharmaceutical and biomedical analysis 20120125
Menstrual cycle-dependent febrile episode mediated by sequence-specific repression of poly(ADP-ribose) polymerase-1 on the transcription of the human serotonin receptor 1A gene. Human mutation 20120101
An efficient synthesis of aripiprazole, buspirone and NAN-190 by the reductive alkylation of amines procedure. Archiv der Pharmazie 20120101
Interventions for treating anxiety after stroke. The Cochrane database of systematic reviews 20111207
Interaction of estrogen with central serotonergic mechanisms in human sensory processing: loudness dependence of the auditory evoked potential and mismatch negativity. Journal of psychopharmacology (Oxford, England) 20111201
Buspirone for bruxism in a child with pervasive developmental disorder-not otherwise specified. Journal of child and adolescent psychopharmacology 20111201
Quantitative estimation of circulating metabolites without synthetic standards by ultra-high-performance liquid chromatography/high resolution accurate mass spectrometry in combination with UV correction. Rapid communications in mass spectrometry : RCM 20111115
Does the presence of accompanying symptom clusters differentiate the comparative effectiveness of second-line medication strategies for treating depression? Depression and anxiety 20111101
Pharmacological treatment of generalized anxiety disorder. Expert opinion on pharmacotherapy 20111101
Buspirone before prenatal stress protects against adverse effects of stress on emotional and inflammatory pain-related behaviors in infant rats: age and sex differences. Brain research 20111024
A pilot study of the efficacy and safety of paroxetine augmented with risperidone, valproate, buspirone, trazodone, or thyroid hormone in adult Chinese patients with treatment-resistant major depression. Journal of clinical psychopharmacology 20111001
Attenuation of apomorphine-induced sensitization by buspirone. Pharmacology, biochemistry, and behavior 20110901
Effects of anxiolytics in zebrafish: similarities and differences between benzodiazepines, buspirone and ethanol. Pharmacology, biochemistry, and behavior 20110901
Buspirone, fexofenadine, and omeprazole: quantification of probe drugs and their metabolites in human plasma. Journal of pharmaceutical and biomedical analysis 20110715
Phasic and sustained fear are pharmacologically dissociable in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20110701
The effect of component of microemulsions on transdermal delivery of buspirone hydrochloride. Journal of pharmaceutical sciences 20110601
[Serotonin receptor 1A-modulated dephosphorylation of glycine receptor α3: a new molecular mechanism of breathing control for compensation of opioid-induced respiratory depression without loss of analgesia]. Schmerz (Berlin, Germany) 20110601
Drug therapies for tardive dyskinesia: Part 1. Journal of psychosocial nursing and mental health services 20110601
Increased plasma corticosterone levels after periaqueductal gray stimulation-induced escape reaction or panic attacks in rats. Behavioural brain research 20110415
Development and evaluation of a multiple-plate fraction collector for sample processing: application to radioprofiling in drug metabolism studies. Journal of pharmaceutical and biomedical analysis 20110405
Agonists at the serotonin receptor (5-HT(1A)) protect the retina from severe photo-oxidative stress. Investigative ophthalmology & visual science 20110404
Study of potential inhibitors of thyroid iodide uptake by using CHO cells stably expressing the human sodium/iodide symporter (hNIS) protein. Journal of endocrinological investigation 20110301
Maternal buspirone protects against the adverse effects of in utero stress on emotional and pain-related behaviors in offspring. Physiology & behavior 20110201
Application of a fluorescence-based continuous-flow bioassay to screen for diversity of cytochrome P450 BM3 mutant libraries. Journal of biomolecular screening 20110201
[Effects of chronic buspirone treatment on female mice exposed to the long-lasting psychoemotional influence]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20110201
The mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) potentiates conditioned place preference induced by various addictive and non-addictive drugs in rats. Addiction biology 20110101
Anxiolytic and anxiogenic drug effects on male and female gerbils in the black-white box. Behavioural brain research 20110101
Density and function of central serotonin (5-HT) transporters, 5-HT1A and 5-HT2A receptors, and effects of their targeting on BTBR T+tf/J mouse social behavior. Journal of neurochemistry 20110101
Pharmacological treatment of cannabis dependence. Current pharmaceutical design 20110101
Zebrafish assessment of cognitive improvement and anxiolysis: filling the gap between in vitro and rodent models for drug development. Reviews in the neurosciences 20110101
Duloxetine-induced nocturnal bruxism resolved by buspirone: case report. Clinical neuropharmacology 20110101
Buspirone improves the anti-cataleptic effect of levodopa in 6-hydroxydopamine-lesioned rats. Pharmacological reports : PR 20110101
Generalised anxiety disorder. BMJ clinical evidence 20110101
Hydroxyzine for generalised anxiety disorder. The Cochrane database of systematic reviews 20101208
Formulation and optimization of solid lipid nanoparticles of buspirone HCl for enhancement of its oral bioavailability. Journal of liposome research 20101201
Buspirone versus methylphenidate in the treatment of attention deficit hyperactivity disorder: a double-blind and randomized trial. Child psychiatry and human development 20101201
Evaluation of central serotonin sensitivity in breast cancer survivors with cancer-related fatigue syndrome. Journal of pain and symptom management 20101201
Attenuation of fear-like response by escitalopram treatment after electrical stimulation of the midbrain dorsolateral periaqueductal gray. Experimental neurology 20101201
A double-blind, randomized, and placebo-controlled trial of buspirone added to risperidone in patients with chronic schizophrenia. Journal of clinical psychopharmacology 20101201
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. Bioorganic & medicinal chemistry letters 20101101
Graft-induced dyskinesias in Parkinson's disease: what is it all about? Cell stem cell 20100806
Agonist-dependent modulation of G-protein coupling and transduction of 5-HT1A receptors in rat dorsal raphe nucleus. The international journal of neuropsychopharmacology 20100801
Chronic buspirone treatment decreases 5-HT1B receptor densities and the serotonin transporter but increases the density of 5-HT2A receptors in the bulbectomized rat model of depression: an autoradiographic study. Brain research 20100723
Dose-effect study of Gelsemium sempervirens in high dilutions on anxiety-related responses in mice. Psychopharmacology 20100701
The pharmacologic treatment of anxiety disorders: a review of progress. The Journal of clinical psychiatry 20100701
Effect of acute and chronic buspirone administration on communicativeness of mice with experience of defeats in social conflicts. Bulletin of experimental biology and medicine 20100701
Enhanced bioavailability of buspirone from reservoir-based transdermal therapeutic system, optimization of formulation employing Box-Behnken statistical design. AAPS PharmSciTech 20100601
Hormonal responses to the 5-HT1A agonist buspirone in remitted endogenous depressive patients after long-term imipramine treatment. Psychoneuroendocrinology 20100501
Buspirone-induced changes in the serotonergic and non-serotonergic cells in the dorsal raphe nucleus of rats. Neuroscience letters 20100405
Venlafaxine-associated nocturnal bruxism in a depressive patient successfully treated with buspirone. Journal of psychopharmacology (Oxford, England) 20100401
Randomized, single-blind, trial of sertraline and buspirone for treatment of elderly patients with generalized anxiety disorder. Psychiatry and clinical neurosciences 20100401
Oral administration of a tri-therapy for central pattern generator activation in paraplegic mice: proof-of-concept of efficacy. Biotechnology journal 20100401
Buspirone attenuates tolerance to analgesic effect of morphine in mice with skin cancer. Pakistan journal of pharmaceutical sciences 20100401
[Effects of prenatal influences of buspirone and stress on indices of inflammatory pain response and depressive behaviour in adult rats]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20100401
Oxidative stress in rat hippocampus caused by pilocarpine-induced seizures is reversed by buspirone. Brain research bulletin 20100316
Buspirone transdermal administration for menopausal syndromes, in vitro and in animal model studies. International journal of pharmaceutics 20100315
5HT1A-mediated stimulation of cortisol release in major depression: use of non-invasive cortisol measurements to predict clinical response. European archives of psychiatry and clinical neuroscience 20100301
Effect of serotonergic system on AVP secretion induced by physical exercise. Neuropeptides 20100201
The alarm pheromone in male rats as a unique anxiety model: psychopharmacological evidence using anxiolytics. Pharmacology, biochemistry, and behavior 20100201
Mouse models of apnea: strain differences in apnea expression and its pharmacologic and genetic modification. Advances in experimental medicine and biology 20100101
Differential involvement of 5-HT(1A) and 5-HT(1B/1D) receptors in human interferon-alpha-induced immobility in the mouse forced swimming test. Arzneimittel-Forschung 20100101
Buspirone improves 6-hydroxydopamine-induced catalepsy through stimulation of nigral 5-HT(1A) receptors in rats. Pharmacological reports : PR 20100101
PRX-00023, a selective serotonin 1A receptor agonist, reduces ultrasonic vocalizations in infant rats bred for high infantile anxiety. Pharmacology, biochemistry, and behavior 20091101
Buspirone, chlordiazepoxide and diazepam effects in a zebrafish model of anxiety. Pharmacology, biochemistry, and behavior 20091101
A placebo-controlled trial of buspirone for the treatment of marijuana dependence. Drug and alcohol dependence 20091101
Pharmacogenetics studies in STAR*D: strengths, limitations, and results. Psychiatric services (Washington, D.C.) 20091101
The effects of buspirone and diazepam on aversive context- and social isolation-induced ultrasonic vocalisation. Physiology & behavior 20091019
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nature chemical biology 20091001
Serotonin targets inhibitory synapses to induce modulation of network functions. Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20090912
Two-injection workflow for a liquid chromatography/LTQ-Orbitrap system to complete in vivo biotransformation characterization: demonstration with buspirone metabolite identification. Rapid communications in mass spectrometry : RCM 20090901
Development of high performance liquid chromatography method for buspirone in rabbit serum: Application to pharmacokinetic study. Analytica chimica acta 20090811
Treatment of cognitive dysfunction in chronic schizophrenia by augmentation of atypical antipsychotics with buspirone, a partial 5-HT(1A) receptor agonist. Human psychopharmacology 20090801
Carboxy group derivatization for enhanced electron-transfer dissociation mass spectrometric analysis of phosphopeptides. Proteomics 20090801
The sigma-1 antagonist BMY-14802 inhibits L-DOPA-induced abnormal involuntary movements by a WAY-100635-sensitive mechanism. Psychopharmacology 20090701
Suppression of shivering during hypothermia using a novel drug combination in healthy volunteers. Anesthesiology 20090701
The partial 5-HT1A receptor agonist buspirone enhances neurogenesis in the opossum (Monodelphis domestica). European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20090601
Anxiolytic-like effects of ginsenosides Rg3 and Rh2 from red ginseng in the elevated plus-maze model. Planta medica 20090601
Proposal of buspirone collision-induced dissociation rearrangement by exact mass measurements. Rapid communications in mass spectrometry : RCM 20090601
Spectroscopic study of the reaction mechanism of buspirone interaction with iodine and tetracyanoethylene reagents and its applications. Drug testing and analysis 20090601
Anxiolytics antagonize yohimbine-induced central noradrenergic activity: a concomitant in vivo voltammetry-electrophysiology model of anxiety. Journal of neuroscience methods 20090530
What predicts attrition in second step medication treatments for depression?: a STAR*D Report. The international journal of neuropsychopharmacology 20090501
Ice-cold saline for the induction of mild hypothermia in patients with acute ischemic stroke: a pilot study. Stroke 20090501
Brain targeting studies on buspirone hydrochloride after intranasal administration of mucoadhesive formulation in rats. The Journal of pharmacy and pharmacology 20090501
The effect of oral buspirone, pyridostigmine, and bethanechol on esophageal function evaluated with combined multichannel esophageal impedance-manometry in healthy volunteers. Journal of clinical gastroenterology 20090301
Sensitization, duration, and pharmacological blockade of anxiety-like behavior following repeated ethanol withdrawal in adolescent and adult rats. Alcoholism, clinical and experimental research 20090301
Synthesis and pharmacological evaluation of aminopyrimidine series of 5-HT1A partial agonists. Bioorganic & medicinal chemistry letters 20090215
Porcine buccal mucosa as an in vitro model: relative contribution of epithelium and connective tissue as permeability barriers. Journal of pharmaceutical sciences 20090201
Prevalence of ergot derivatives in natural ryegrass pastures: detection and pathogenicity in the horse. Theriogenology 20090201
Preliminary evidence of safety following administration of L-DOPA and buspirone in an incomplete monoplegic patient. Spinal cord 20090101
5-HT(1A) receptors in the frontal cortical brain areas in Cloninger type 1 and 2 alcoholics measured by whole-hemisphere autoradiography. Alcohol and alcoholism (Oxford, Oxfordshire) 20090101
Both acute and chronic buspirone treatments have different effects on regional 5-HT synthesis in Flinders Sensitive Line rats (a rat model of depression) than in control rats. Neurochemistry international 20090101
Augmentation strategies for treatment-resistant depression. Current opinion in psychiatry 20090101
Combined neuroprotective modalities coupled with thrombolysis in acute ischemic stroke: a pilot study of caffeinol and mild hypothermia. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 20090101
Refractory generalized anxiety disorder. The Journal of clinical psychiatry 20090101
Effect of buspirone on thermal sensory and pain thresholds in human volunteers. BMC clinical pharmacology 20090101
Reduction of the number of new cells reaching olfactory bulbs impairs olfactory perception in the adult opossum. Acta neurobiologiae experimentalis 20090101
Low-dose buspirone, melatonin and low-dose bupropion added to mood stabilizers for severe treatment-resistant bipolar depression. Psychotherapy and psychosomatics 20090101
Fluoxetine-induced sleep bruxism in an adolescent treated with buspirone: a case report. Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry 20090101
Interaction between serotonin 5-HT1A receptors and beta-endorphins modulates antidepressant response. Progress in neuro-psychopharmacology & biological psychiatry 20081212
Influence of buspirone on gastric sensorimotor function in man. Alimentary pharmacology & therapeutics 20081201
Anxiolytic activity of a phytochemically characterized Passiflora incarnata extract is mediated via the GABAergic system. Planta medica 20081201
Modulation of buspirone HCl release from hypromellose matrices using chitosan succinate: implications for pH-independent release. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20081101
The molecular interactions of buspirone analogues with the serotonin transporter. Bioorganic & medicinal chemistry 20081015
Serotonin1A receptors in the pathophysiology of schizophrenia: development of novel cognition-enhancing therapeutics. Advances in therapy 20081001
Dose-dependent response of central dopaminergic systems to buspirone in mice. Indian journal of experimental biology 20081001
Can in vitro metabolism-dependent covalent binding data in liver microsomes distinguish hepatotoxic from nonhepatotoxic drugs? An analysis of 18 drugs with consideration of intrinsic clearance and daily dose. Chemical research in toxicology 20080901
The efficacy of combined estrogen and buspirone treatment in olivopontocerebellar atrophy. Journal of the neurological sciences 20080815
Effects of buspirone on posthypoxic ventilatory behavior in the C57BL/6J and A/J mouse strains. Journal of applied physiology (Bethesda, Md. : 1985) 20080801
Post-sigh breathing behavior and spontaneous pauses in the C57BL/6J (B6) mouse. Respiratory physiology & neurobiology 20080731
Buspirone induced acute and chronic changes of neural activation in the periaqueductal gray of rats. Neuroscience 20080731
Evidence of an enhanced central 5HT response in irritable bowel syndrome and in the rat maternal separation model. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20080601
Sustained-release of buspirone HCl by co spray-drying with aqueous polymeric dispersions. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20080601
In vitro assessment of mitochondrial dysfunction and cytotoxicity of nefazodone, trazodone, and buspirone. Toxicological sciences : an official journal of the Society of Toxicology 20080601
Apneusis responding to buspirone in multiple sclerosis. Multiple sclerosis (Houndmills, Basingstoke, England) 20080601
Validating an Ataxia Functional Composite Scale in spinocerebellar ataxia. Journal of the neurological sciences 20080515
Buspirone and serotonin in spinocerebellar ataxia. Journal of the neurological sciences 20080515
Effects of fluoxetine on hippocampal rhythmic slow activity and behavioural inhibition. Behavioural pharmacology 20080501
How multiple medication use evolves and the importance of therapeutic trials: the slippery slide. Journal of psychiatric practice 20080501
Intranasal mucoadhesive buspirone formulation: in vitro characterization and nasal clearance studies. Die Pharmazie 20080501
Chronic buspirone treatment normalizes open field behavior in olfactory bulbectomized rats: assessment with a quantitative autoradiographic evaluation of the 5-HT1A binding sites. Brain research bulletin 20080328
Treating body dysmorphic disorder with medication: evidence, misconceptions, and a suggested approach. Body image 20080301
Pharmacotherapy and psychotherapy in cannabis withdrawal and dependence. Expert review of neurotherapeutics 20080301
The stimulus effects of 8-OH-DPAT: evidence for a 5-HT2A receptor-mediated component. Pharmacology, biochemistry, and behavior 20080101
Comparison of the effects of deramciclane, ritanserin and buspirone on extracellular dopamine and its metabolites in striatum and nucleus accumbens of freely moving rats. Basic & clinical pharmacology & toxicology 20080101
Buspirone for autistic disorder in a woman with an intellectual disability. The Annals of pharmacotherapy 20080101
Effects of midazolam and buspirone on in vivo concentration of amino acids and monoamine metabolites in the rat hippocampus. Pharmacological reports : PR 20080101
Effect of buspirone on the behavioral regulation of rats in low versus high anxiety conditions. Arzneimittel-Forschung 20080101
Marijuana neurobiology and treatment. Substance abuse 20080101
Rapid and sensitive characterization of the metabolite formation enzyme kinetics of radiolabeled drugs using stop-flow liquid radiochromatography. Drug metabolism letters 20080101
Tolerance in the anxiolytic profile following repeated administration of diazepam but not buspirone is associated with a decrease in the responsiveness of postsynaptic 5-HT-1A receptors. Acta biologica Hungarica 20071201
Allometric scaling of pharmacodynamic responses: application to 5-Ht1A receptor mediated responses from rat to man. Pharmaceutical research 20071101
Repeated cortisol administration attenuates the EEG response to buspirone in healthy volunteers: evidence for desensitization of the 5-HT1A autoreceptor. Journal of psychopharmacology (Oxford, England) 20071101
Behavioral response to emotional stress in rabbits: role of serotonin and serotonin2A receptors. Behavioural pharmacology 20071101
[Pharmacological therapy for therapy-resistant depression. New developments]. Der Nervenarzt 20071101
Response surface analysis of solution-mediated polymorphic transformation of buspirone hydrochloride. Journal of pharmaceutical and biomedical analysis 20071018
Defensive-like behaviors induced by ultrasound: further pharmacological characterization in Lister-hooded rats. Psychopharmacology 20071001
Dose related effects of buspirone on serum electrolyte balance, plasma osmolality and systolic blood pressure (SBP) in rats. Pakistan journal of pharmaceutical sciences 20071001
Pharmacokinetics of 6-hydroxybuspirone and its enantiomers administered individually or following buspirone administration in humans. Biopharmaceutics & drug disposition 20071001
alpha1-Adrenoceptors in proximal segments of tail arteries from control and reserpinised rats. Naunyn-Schmiedeberg's archives of pharmacology 20071001
Augmentation strategies for treatment-resistant depression: a literature review. Journal of clinical pharmacy and therapeutics 20071001
The efficacy of the combination of sertraline with buspirone for smoking cessation. A randomized clinical trial in nondepressed smokers. European archives of psychiatry and clinical neuroscience 20071001
Treatment of spinocerebellar ataxia with buspirone. Journal of the neurological sciences 20070915
Drug challenges reveal differences in mediation of stress facilitation of voluntary alcohol drinking and withdrawal-induced anxiety in alcohol-preferring P rats. Alcoholism, clinical and experimental research 20070901
Effect of buspirone, a serotonin1A partial agonist, on cognitive function in schizophrenia: a randomized, double-blind, placebo-controlled study. Schizophrenia research 20070901
6-Hydroxybuspirone is a major active metabolite of buspirone: assessment of pharmacokinetics and 5-hydroxytryptamine1A receptor occupancy in rats. Drug metabolism and disposition: the biological fate of chemicals 20070801
Hormonal response to buspirone is not impaired in major depression. Human psychopharmacology 20070801
Simultaneous determination of metabolic stability and identification of buspirone metabolites using multiple column fast liquid chromatography time-of-flight mass spectrometry. Journal of chromatography. A 20070713
Solubility analysis of buspirone hydrochloride polymorphs: measurements and prediction. International journal of pharmaceutics 20070629
Mass spectrometric investigation of buspirone drug in comparison with thermal analyses and MO-calculations. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20070601
Unintentional onset of anorexia nervosa. Eating and weight disorders : EWD 20070601
Effects of cytochrome P450 (CYP) 3A4 inhibitors on the anxiolytic action of tandospirone in rat contextual conditioned fear. Progress in neuro-psychopharmacology & biological psychiatry 20070509
Effects of citalopram treatment on hypothermic and hormonal responses to the 5-HT1A receptor agonist buspirone in patients with major depression and therapeutic response. Psychoneuroendocrinology 20070501
Cognitive therapy versus medication in augmentation and switch strategies as second-step treatments: a STAR*D report. The American journal of psychiatry 20070501
Reversal of haloperidol-induced tardive vacuous chewing movements and supersensitive somatodendritic serotonergic response by buspirone in rats. Pharmacology, biochemistry, and behavior 20070501
Mania in a case of polypsychopharmacology: pharmacodynamic and pharmacokinetic considerations. Do you believe in magic? Journal of psychiatric practice 20070501
Effects of buspirone on the immediate positive and delayed negative properties of intravenous cocaine as measured in the conditioned place preference test. Pharmacology, biochemistry, and behavior 20070501
Anti-anxiety effects of Apocynum venetum L. in the elevated plus maze test. Journal of ethnopharmacology 20070404
Quantitative and molecular analysis of buspirone hydrochloride polymorphs. Journal of pharmaceutical sciences 20070301
Lack of deleterious effects of buspirone on cognition in healthy male volunteers. Journal of psychopharmacology (Oxford, England) 20070301
Reversal of haloperidol-induced extrapyramidal symptoms by buspirone: a time-related study. Behavioural pharmacology 20070301
Screening of 5-HT1A receptor antagonists using molecularly imprinted polymers. Journal of the American Chemical Society 20070214
Modulation of fear-potentiated startle and vocalizations in juvenile rhesus monkeys by morphine, diazepam, and buspirone. Biological psychiatry 20070201
The effect of buspirone on normal and hypoarousal-driven abnormal aggression in rats. Progress in neuro-psychopharmacology & biological psychiatry 20070130
The partial 5-hydroxytryptamine1A receptor agonist buspirone does not antagonize morphine-induced respiratory depression in humans. Clinical pharmacology and therapeutics 20070101
Treating inhalant abuse with buspirone. The American journal on addictions 20070101
The partial 5-HT(1A) agonist buspirone reduces the expression and development of l-DOPA-induced dyskinesia in rats and improves l-DOPA efficacy. Pharmacology, biochemistry, and behavior 20070101
The combination of buspirone and bupropion in the treatment of depression. Psychotherapy and psychosomatics 20070101
Flow injection analysis with tubular membrane ion-selective electrode and coated wires for buspirone hydrochloride. Annali di chimica 20070101
Augmentation strategies to increase antidepressant efficacy. The Journal of clinical psychiatry 20070101
Effects of buspirone on dopamine dependent behaviours in rats. Indian journal of physiology and pharmacology 20070101
Anxiolytic activity of a novel potent serotonin 5-HT2C receptor antagonist FR260010: a comparison with diazepam and buspirone. European journal of pharmacology 20061228
Assay principle for modulators of protein-protein interactions and its application to non-ATP-competitive ligands targeting protein kinase A. Analytical chemistry 20061215
Quantification of a cytochrome P450 3A4 substrate, buspirone, in human plasma by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20061205
Strategies for managing antidepressant-induced sexual dysfunction: a review. Current psychiatry reports 20061201
Use of a serotonin 1A receptor agonist to treat restless legs syndrome. Journal of clinical psychopharmacology 20061201
Anxiolytic effects of the aqueous extract of Uncaria rhynchophylla. Journal of ethnopharmacology 20061124
Involvement of 5-hydroxytryptamine1A receptors in Delta9-tetrahydrocannabinol-induced catalepsy-like immobilization in mice. European journal of pharmacology 20061121
Effects of genetic background and null mutation of 5-HT1A receptors on basal and stress-induced body temperature: modulation by serotonergic and GABAA-ergic drugs. European journal of pharmacology 20061121
Pharmacokinetics of a newly identified active metabolite of buspirone after administration of buspirone over its therapeutic dose range. Journal of clinical pharmacology 20061101
An increased hypothermic response to buspirone in patients with major depression. Psychopharmacology 20061001
Anxiolytic-like actions of buspirone in a runway model of intravenous cocaine self-administration. Pharmacology, biochemistry, and behavior 20061001
5-HT-1A receptor responsiveness following subchronic administration of buspirone. Pakistan journal of pharmaceutical sciences 20061001
Rapid desensitization of somatodendritic 5-HT1A receptors by chronic administration of the high-efficacy 5-HT1A agonist, F13714: a microdialysis study in the rat. British journal of pharmacology 20060901
Thermal effects of whole head submersion in cold water on nonshivering humans. Journal of applied physiology (Bethesda, Md. : 1985) 20060801
Antidepressant-induced bruxism: need for buspirone? The international journal of neuropsychopharmacology 20060801
Azapirones for generalized anxiety disorder. The Cochrane database of systematic reviews 20060719
Therapeutic options: Addressing the current dilemma. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20060701
Reduction in repeated ethanol-withdrawal-induced anxiety-like behavior by site-selective injections of 5-HT1A and 5-HT2C ligands. Psychopharmacology 20060701
Depression--augmentation or switch after initial SSRI treatment. The New England journal of medicine 20060615
Enantioselective alpha-hydroxylation of 2-arylacetic acid derivatives and buspirone catalyzed by engineered cytochrome P450 BM-3. Journal of the American Chemical Society 20060510
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Pharmacokinetics of buspirone in autistic children. Journal of clinical pharmacology 20060501
Solid-state characterization of buspirone hydrochloride polymorphs. Pharmaceutical research 20060501
Estrogen prevents 5-HT1A receptor-induced disruptions of prepulse inhibition in healthy women. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20060401
Inhibition of hepatobiliary transport as a predictive method for clinical hepatotoxicity of nefazodone. Toxicological sciences : an official journal of the Society of Toxicology 20060401
Chronic buspirone treatment normalizes regional serotonin synthesis in the olfactory bulbectomized rat brain: an autoradiographic study. Brain research bulletin 20060331
Pharmacological evaluation of the stress-induced social avoidance model of anxiety. Brain research bulletin 20060331
Potential vascular alpha1-adrenoceptor blocking properties of an array of 5-HT receptor ligands in the rat. European journal of pharmacology 20060327
Medication augmentation after the failure of SSRIs for depression. The New England journal of medicine 20060323
Anxiolytic-like activity of agomelatine and melatonin in three animal models of anxiety. Behavioural pharmacology 20060201
Automated software-guided identification of new buspirone metabolites using capillary LC coupled to ion trap and TOF mass spectrometry. Journal of mass spectrometry : JMS 20060201
[Review of neurobehavioral effects of alcohol-related neurodevelopmental disorder in an animal model]. Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence 20060201
Effect of modulation of serotonergic, cholinergic, and nitrergic pathways on murine fundic size and compliance measured by ultrasonomicrometry. American journal of physiology. Gastrointestinal and liver physiology 20060101
Immediate-early gene expression in the central nucleus of the amygdala is not specific for anxiolytic or anxiogenic drugs. Neuropharmacology 20060101
Effects of fluoxetine and buspirone on the panicolytic-like response induced by the activation of 5-HT1A and 5-HT2A receptors in the rat dorsal periaqueductal gray. Psychopharmacology 20060101
Anti-conflict effects of benzodiazepines in rhesus monkeys: relationship with therapeutic doses in humans and role of GABAA receptors. Psychopharmacology 20060101
Combined treatment with citalopram and buspirone: effects on serotonin 5-HT2A and 5-HT2C receptors in the rat brain. Pharmacopsychiatry 20060101
Hyper-anxiety in early sobriety: psychopharmacological treatment strategies. Journal of psychosocial nursing and mental health services 20060101
Rapid and highly sensitive liquid chromatography/electrospray ionization tandem mass spectrometry method for the quantitation of buspirone in human plasma: application to a pharmacokinetic study. Rapid communications in mass spectrometry : RCM 20060101
Buspirone for stereotypic movements in elderly with cognitive impairment. The Journal of neuropsychiatry and clinical neurosciences 20060101
[Efficacy of buspirone and fluoxetine in short-term treatment of bulimia nervosa]. Psychiatria polska 20060101
Challenging the serotonergic system in Parkinson disease patients: effects on cognition, mood, and motor performance. Clinical neuropharmacology 20060101
Buspirone for treatment of marijuana dependence: a pilot study. The American journal on addictions 20060101
[Neonatal buspirone modulates the intermale aggression in adult mice]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 20060101
Inhibition of restraint-induced neuroendocrine and serotonergic responses by buspirone in rats. Pharmacological reports : PR 20060101
Psychiatric treatment for extremely traumatized civil war refugees from former Yugoslavia. Possibilities and limitations of integrating psychotherapy and medication. Torture : quarterly journal on rehabilitation of torture victims and prevention of torture 20060101
Buspirone attenuates conditioned fear-induced c-Fos expression in the rat hippocampus. Neuroscience letters 20051202
Role of sex and sex steroids in mediating pituitary-adrenal responses to acute buspirone treatment in sheep. Journal of neuroendocrinology 20051201
Motor effects of buspirone: Relationship with dopamine and serotonin in the striatum. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 20051201
Attenuation of restraint induced behavioral deficits by buspirone and propranolol in rats. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 20051201
Generalised anxiety disorder. Clinical evidence 20051201
Chronic imipramine treatment sensitizes 5-HT1A and 5-HT 2 A receptors in the dorsal periaqueductal gray matter: evidence from the elevated T-maze test of anxiety. Behavioural pharmacology 20051101
The use of sleep measures to compare a new 5HT1A agonist with buspirone in humans. Journal of psychopharmacology (Oxford, England) 20051101
Co-administration of fluoxetine and WAY100635 improves short-term memory function. European journal of pharmacology 20051017
The 5-HT1A receptor and the stimulus effects of LSD in the rat. Psychopharmacology 20051001
Prior multiple ethanol withdrawals enhance stress-induced anxiety-like behavior: inhibition by CRF1- and benzodiazepine-receptor antagonists and a 5-HT1a-receptor agonist. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20050901
Analysis of low level radioactive metabolites in biological fluids using high-performance liquid chromatography with microplate scintillation counting: method validation and application. Journal of pharmaceutical and biomedical analysis 20050901
Buspirone in Rett syndrome respiratory dysfunction. Brain & development 20050901
Efficacy of the 5-HT1A agonist, buspirone hydrochloride, in migraineurs with anxiety: a randomized, prospective, parallel group, double-blind, placebo-controlled study. Headache 20050901
Use of buspirone and enrichment to manage aberrant behavior in an American badger (Taxidea taxus). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20050901
Differential distribution of functional alph}1-adrenergic receptor subtypes along the rat tail artery. The Journal of pharmacology and experimental therapeutics 20050801
Hybrid triple quadrupole-linear ion trap mass spectrometry in fragmentation mechanism studies: application to structure elucidation of buspirone and one of its metabolites. Journal of mass spectrometry : JMS 20050801
Postnatal treatment with NAN-190 but not with 5-HT1A receptor agonists retards growth of the rat brain. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20050801
In vitro profile of the antidepressant candidate OPC-14523 at rat and human 5-HT1A receptors. European journal of pharmacology 20050711
Influence of inflammatory nociception on the anxiolytic-like effect of diazepam and buspirone in rats. Psychopharmacology 20050701
Pharmacological validation of a mouse model of l-DOPA-induced dyskinesia. Experimental neurology 20050701
Involvement of central serotonergic systems in dextromethorphan-induced behavioural syndrome in rats. Indian journal of experimental biology 20050701
Efficacy of buspirone in the treatment of opioid withdrawal. Journal of clinical psychopharmacology 20050601
Anxiolytic suppression of repetitive transcranial magnetic stimulation-induced anxiety in the rats. Progress in neuro-psychopharmacology & biological psychiatry 20050601
Temperament and character inventory and pharmacotherapeutic outcome in bulimia nervosa. Eating and weight disorders : EWD 20050601
Respiratory abnormalities resulting from midcervical spinal cord injury and their reversal by serotonin 1A agonists in conscious rats. The Journal of neuroscience : the official journal of the Society for Neuroscience 20050504
Oral buspirone causes a shift in the dose-response curve between the elevated-plus maze and Vogel conflict tests in Long-Evans rats: relation of brain levels of buspirone and 1-PP to anxiolytic action. Methods and findings in experimental and clinical pharmacology 20050501
Cytochrome P450 3A-mediated metabolism of buspirone in human liver microsomes. Drug metabolism and disposition: the biological fate of chemicals 20050401
Altered neuroendocrine response and gastric dysmotility in the Flinders Sensitive Line rat. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20050401
Inhibitory effects of the 5-HT(1A) receptor agonist buspirone on stress-induced hyperglycemia in mice: involvement of insulin and a buspirone metabolite, 1-(2-pyrimidinyl)piperazine (1-PP). Biological & pharmaceutical bulletin 20050401
The naturally occurring Arg219Leu variant of the human 5-HT1A receptor: impairment of signal transduction. Pharmacogenetics and genomics 20050401
Effect of lactic acid and iontophoresis on drug permeation across rabbit ear skin. International journal of pharmaceutics 20050323
The effects of fluoxetine and buspirone on self-injurious and stereotypic behavior in adult male rhesus macaques. Comparative medicine 20050201
Effect of the postsynaptic 5-HT1A receptor antagonist MM-77 on stressed mice treated with 5-HT1A receptor agents. European journal of pharmacology 20050131
Incidence of sexual side effects in refractory depression during treatment with citalopram or paroxetine. The Journal of clinical psychiatry 20050101
Substance use disorder comorbidity in major depressive disorder: an exploratory analysis of the Sequenced Treatment Alternatives to Relieve Depression cohort. Comprehensive psychiatry 20050101
Buccal permeation of buspirone: mechanistic studies on transport pathways. Journal of pharmaceutical sciences 20050101
Tardive dyskinesia predicts prolactin response to buspirone challenge in people with schizophrenia. The Journal of neuropsychiatry and clinical neurosciences 20050101
Treatment of cerebellar ataxia with 5-HT1A agonist. Cerebellum (London, England) 20050101
Switching patients from olanzapine or risperidone to a combination treatment using perphenazine plus buspirone: evaluation of antipsychotic efficacy and side-effects, including extrapyramidal effects and weight loss. Nordic journal of psychiatry 20050101
The role of buspirone for the treatment of cerebellar ataxia in an older individual. The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique 20050101
Potentiation strategies for treatment-resistant depression. Acta psychiatrica Scandinavica. Supplementum 20050101
Comorbid anxiety and depression. The Journal of clinical psychiatry 20050101
Buspirone to improve compliance in venlafaxine-induced movement disorder. The international journal of neuropsychopharmacology 20041201
Somatodendritic and postsynaptic serotonin-1A receptors in the attenuation of haloperidol-induced catalepsy. Progress in neuro-psychopharmacology & biological psychiatry 20041201
Generalised anxiety disorder. Clinical evidence 20041201
Rapid high-performance liquid chromatographic measurement of buspirone in human plasma after overdose. Biomedical chromatography : BMC 20041101
Interactions between anxiety, social support, health status and buspirone efficacy in elderly patients. Progress in neuro-psychopharmacology & biological psychiatry 20041101
Magnesium sulfate increases the rate of hypothermia via surface cooling and improves comfort. Stroke 20041001
Anxiolytic effect of berberine on exploratory activity of the mouse in two experimental anxiety models: interaction with drugs acting at 5-HT receptors. Life sciences 20041001
Psychosocial conditions and the efficacy of clinically available anxiolytics. Current drug targets 20041001
Effects of injection of serotonin into nucleus caudatus on food and water intake and body weight in albino rats. Indian journal of physiology and pharmacology 20041001
Simple high-performance liquid chromatographic determination of buspirone in human plasma. Farmaco (Societa chimica italiana : 1989) 20040901
Paroxetine in the treatment of generalised anxiety disorder. Expert opinion on pharmacotherapy 20040801
Cooling for Acute Ischemic Brain Damage (COOL AID): a feasibility trial of endovascular cooling. Neurology 20040727
Social instability in female rats: effects on anxiety and buspirone efficacy. Psychopharmacology 20040701
Effect of the 5HT1A receptor partial agonist buspirone on colorectal distension-induced pseudoaffective and behavioral responses in the female Wistar rat. European journal of pharmacology 20040621
Exposure to an elevated platform increases plasma corticosterone and hippocampal acetylcholine in the rat: reversal by chlordiazepoxide. European journal of pharmacology 20040616
Intrinsic activity and comparative molecular dynamics of buspirone analogues at the 5-HT(1A) receptors. Biochemical pharmacology 20040615
Buspirone raises blood pressure through activation of sympathetic nervous system and by direct activation of alpha1-adrenergic receptors after severe hemorrhage. The Journal of pharmacology and experimental therapeutics 20040601
Buspirone challenge is not a valid probe of central 5-HT1A receptor function. Cephalalgia : an international journal of headache 20040601
Prediction of the affinity of the newly synthesised azapirone derivatives for 5-HT1A receptors based on artificial neural network analysis of chromatographic retention data and calculation chemistry parameters. Combinatorial chemistry & high throughput screening 20040601
Genotype-dependent changes in pain thresholds in adult mice after neonatal treatment. Bulletin of experimental biology and medicine 20040601
Generalised anxiety disorder. Clinical evidence 20040601
Effect of environmental enrichment on stress related systems in rats. Journal of neuroendocrinology 20040501
[Combination of serotonergic agents resulted in severe adverse effects]. Lakartidningen 20040429
Effects of acute and chronic buspirone on impulsive choice and efflux of 5-HT and dopamine in hippocampus, nucleus accumbens and prefrontal cortex. Psychopharmacology 20040401
The photocatalytic process as a tool to identify metabolitic products formed from dopant substances: the case of buspirone. Journal of pharmaceutical and biomedical analysis 20040401
Development and validation of a high-performance liquid chromatographic method for the determination of buspirone in pharmaceutical preparations. Journal of pharmaceutical and biomedical analysis 20040401
New imide 5-HT1A receptor ligands - modification of terminal fragment geometry. Molecules (Basel, Switzerland) 20040227
Adsorptive stripping voltammetric behaviour of azomethine group in pyrimidine-containing drugs. Journal of pharmaceutical and biomedical analysis 20040218
Systemic absorption of amitriptyline and buspirone after oral and transdermal administration to healthy cats. Journal of veterinary internal medicine 20040101
A randomized, placebo-controlled trial of buspirone for the treatment of anxiety in opioid-dependent individuals. The American journal on addictions 20040101
Effects of buspirone and alprazolam treatment on the startle-potentiated startle response. Depression and anxiety 20040101
Cortisol response to buspirone in extended abstinent alcoholics. Alcohol and alcoholism (Oxford, Oxfordshire) 20040101
Neonatal administration of buspiron causes changes in intermale aggression of adult mice. Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 20040101
1-(2-pyrimidinyl)-piperazine, a buspirone metabolite, modulates bladder function in the anesthetized rat. Neurourology and urodynamics 20040101
Selecting pharmacotherapy for generalized anxiety disorder. The Journal of clinical psychiatry 20040101
Effect of the novel anxiolytic drug deramciclane on the pharmacokinetics and pharmacodynamics of the CYP3A4 probe drug buspirone. European journal of clinical pharmacology 20031201
Sensitization of adenylate cyclase by short-term activation of 5-HT1A receptors. Cellular signalling 20031201
The serotonergic system may be involved in the sleep-inducing action of oleamide in rats. Naunyn-Schmiedeberg's archives of pharmacology 20031201
The effect of social factors on the anxiolytic efficacy of buspirone in male rats, male mice, and men. Progress in neuro-psychopharmacology & biological psychiatry 20031201
Effects of the serotonergic anxiolytic buspirone on plasma glucose and glucose-induced hyperglycemia in mice. Journal of pharmacological sciences 20031201
Anxiolytic effects of the novel anti-epileptic drug levetiracetam in the elevated plus-maze test in the rat. European journal of pharmacology 20031114
Buspirone for anxiety and agitation in dementia. Journal of psychiatry & neuroscience : JPN 20031101
Enhanced iontophoretic delivery of buspirone hydrochloride across human skin using chemical enhancers. International journal of pharmaceutics 20031002
Harm avoidance, anxiety, and response to novelty in the adolescent S-100beta transgenic mouse: role of serotonin and relevance to Down syndrome. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20031001
Imipramine and buspirone in patients with panic disorder who are discontinuing long-term benzodiazepine therapy. Journal of clinical psychopharmacology 20031001
Buspirone treatment for apneustic breathing in brain stem infarct. Respiratory care 20031001
Effect of anxiolytic drugs on air-puff-elicited ultrasonic vocalization in adult rats. Experimental animals 20031001
Buspirone differentially modifies short-term memory function in a combined delayed matching/non-matching to position task. European journal of pharmacology 20030923
Faster response in depressive patients treated with fluoxetine alone than in combination with buspirone. Journal of affective disorders 20030901
The safety of SSRIs in generalised anxiety disorder: any reason to be anxious? Expert opinion on drug safety 20030901
Pharmacokinetic evaluation of gepirone immediate-release capsules and gepirone extended-release tablets in healthy volunteers. Journal of pharmaceutical sciences 20030901
Stress, social avoidance and anxiolytics: a potential model of stress-induced anxiety. Behavioural pharmacology 20030901
Effects of highly or relatively selective 5-HT1A receptor agonists on lordosis in female rats. Zoological science 20030901
Methylphenidate-induced obsessive-compulsive symptoms in an elderly man. CNS spectrums 20030801
An open trial of buspirone in the treatment of attention-deficit disorder. Human psychopharmacology 20030801
A quantitative method for assessing of the affective component of the pain: conditioned response associated with CO2 laser-induced nocifensive reaction. Brain research. Brain research protocols 20030801
The phenomenon of one-trial tolerance to the anxiolytic effect of chlordiazepoxide in the elevated plus-maze test is abolished by previous administration of chlordiazepoxide or buspirone. Life sciences 20030711
Effects of autoshaping procedures on 3H-8-OH-DPAT-labeled 5-HT1a binding and 125I-LSD-labeled 5-HT2a binding in rat brain. Brain research 20030613
A 5-HT1A agonist and a 5-HT2c antagonist reduce social interaction deficit induced by multiple ethanol withdrawals in rats. Psychopharmacology 20030601
Responses to exercise in the heat related to measures of hypothalamic serotonergic and dopaminergic function. European journal of applied physiology 20030601
Altered dopamine D2 receptor function in fibromyalgia patients: a neuroendocrine study with buspirone in women with fibromyalgia compared to female population based controls. Journal of affective disorders 20030601
Iontophoretic transdermal delivery of buspirone hydrochloride in hairless mouse skin. AAPS pharmSci 20030601
Generalised anxiety disorder. Clinical evidence 20030601
Serotonin 1A receptor agonists reverse respiratory abnormalities in spinal cord-injured rats. The Journal of neuroscience : the official journal of the Society for Neuroscience 20030515
8-[3H]-hydroxy-2-(di-n-propylamino)tetralin binding sites in blood lymphocytes of rats and the modulation by mitogens and immobilization. Journal of neuroimmunology 20030501
Effects of venlafaxine, buspirone, and placebo on colonic sensorimotor functions in healthy humans. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20030501
22-kHz ultrasonic vocalization in rats as an index of anxiety but not fear: behavioral and pharmacological modulation of affective state. Behavioural brain research 20030417
Buspirone-induced antinociception is mediated by L-type calcium channels and calcium/caffeine-sensitive pools in mice. Psychopharmacology 20030301
EEG effects of buspirone and pindolol: a method of examining 5-HT1A receptor function in humans. Psychopharmacology 20030301
Human cytochromes mediating gepirone biotransformation at low substrate concentrations. Biopharmaceutics & drug disposition 20030301
Effects of chronic treatment with ipsapirone and buspirone on the C57BL/6J strain mice under social stress. Life sciences 20030214
Development and validation of an in vitro-in vivo correlation for buspirone hydrochloride extended release tablets. Journal of controlled release : official journal of the Controlled Release Society 20030214
Central 5-HT receptor hypersensitivity in migraine without aura. Cephalalgia : an international journal of headache 20030201
5-HT1A receptor activity disrupts spontaneous alternation behavior in rats. Pharmacology, biochemistry, and behavior 20030201
Venlafaxine-induced galactorrhea. Journal of clinical psychopharmacology 20030201
Pseudo-Parkinson disease secondary to ritonavir-buspirone interaction. The Annals of pharmacotherapy 20030201
Effect of the serotonin agonist buspirone on behaviour and hypothalamic-pituitary-adrenal axis in confident and fearful mink. Physiology & behavior 20030201
Differing central amine receptor sensitivity in different migraine subtypes? A neuroendocrine study using buspirone. Pain 20030201
Development of a presynaptic 5-HT1A antagonist. Bioorganic & medicinal chemistry letters 20030120
In vivo comparison of two 5-HT1A receptors agonists alnespirone (S-20499) and buspirone on locus coeruleus neuronal activity. European journal of pharmacology 20030110
Buspirone decreases physiological reactivity to unconditioned and conditioned aversive stimuli. Psychopharmacology 20030101
Effects of cholecystokinin tetrapeptide (CCK(4)) and of anxiolytic drugs on GABA outflow from the cerebral cortex of freely moving rats. Neurochemistry international 20030101
Selective effects of serotonergic psychoactive agents on gastrointestinal functions in health. American journal of physiology. Gastrointestinal and liver physiology 20030101
Treating generalized anxiety disorder. The Journal of clinical psychiatry 20030101
Kava-Kava extract LI 150 is as effective as Opipramol and Buspirone in Generalised Anxiety Disorder--an 8-week randomized, double-blind multi-centre clinical trial in 129 out-patients. Phytomedicine : international journal of phytotherapy and phytopharmacology 20030101
Effects of buspirone in withdrawal from opiates. The American journal on addictions 20030101
Electrospray mass spectrometric studies of noncovalent complexes of buspirone hydrochloride and other serotonin 5-HT(1A) receptor ligands containing arylpiperazine moieties. Rapid communications in mass spectrometry : RCM 20030101
[Effect of buspirone on aggressive and anxiety behavior of male mice with various aggressive experience]. Eksperimental'naia i klinicheskaia farmakologiia 20030101
Effects of ethanol and 5-HT1A agonists on astroglial S100B. Brain research. Developmental brain research 20021215
Pharmacokinetic-pharmacodynamic modeling of buspirone and its metabolite 1-(2-pyrimidinyl)-piperazine in rats. The Journal of pharmacology and experimental therapeutics 20021201
Treatment of generalised anxiety disorder with a short course of psychological therapy, combined with buspirone or placebo. Journal of affective disorders 20021201
Indorenate produces antidepressant-like actions in the rat forced swimming test via 5-HT1A receptors. Psychopharmacology 20021201
Treatment functional GI disease: the complex pharmacology of serotonergic drugs. British journal of clinical pharmacology 20021201
Possible serotonin syndrome after combination of buspirone and St John's Wort. Journal of psychopharmacology (Oxford, England) 20021201
Cocaine-induced anxiety: alleviation by diazepam, but not buspirone, dimenhydrinate or diphenhydramine. Behavioural pharmacology 20021101
Modulation of reflexly evoked vagal bradycardias by central 5-HT1A receptors in anaesthetized rabbits. British journal of pharmacology 20021101
Rigid analogues of buspirone and gepirone, 5-HT1A receptors partial agonists. Farmaco (Societa chimica italiana : 1989) 20021101
Effects of triazolam, 8-OH-DPAT, and buspirone on repeated acquisition in squirrel monkeys. Experimental and clinical psychopharmacology 20021101
Developing strategies for isolation of minor impurities with mass spectrometry-directed fractionation. Journal of chromatography. A 20020913
Anxiolytic-like activity of the mGluR5 antagonist MPEP: a comparison with diazepam and buspirone. Pharmacology, biochemistry, and behavior 20020901
The effects of alprazolam and buspirone in light and moderate female social drinkers. Behavioural pharmacology 20020901
Serotonin 1A receptor activation and hypothermia in humans: lack of evidence for a presynaptic mediation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20020801
A preliminary study of buspirone stimulated prolactin release in generalised social phobia: evidence for enhanced serotonergic responsivity? European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20020801
Clinical inquiries. What are the treatment options for SSRI-related sexual dysfunction? The Journal of family practice 20020801
Postsynaptic 5-HT(1A) receptors mediate an increase in locomotor activity in the monoamine-depleted rat. Psychopharmacology 20020801
[Buspirone chlorhydrate in the treatment of cerebellar ataxia]. Revista de neurologia 20020801
[Preparation of buspirone hydrochloride buccal adhesive tablet and study on its drug release mechanism]. Yao xue xue bao = Acta pharmaceutica Sinica 20020801
Influence of forced swimming-induced stress on the anxiolytic-like effect of 5HT(1A) agents in mice. Psychopharmacology 20020701
The use of buspirone in primary care. Journal of psychosocial nursing and mental health services 20020701
Withdrawal from chronic ethanol increases the sensitivity of presynaptic 5-HT(1A) receptors modulating serotonin and dopamine synthesis in rat brain in vivo. Neuroscience letters 20020628
Region-dependent effects of flibanserin and buspirone on adenylyl cyclase activity in the human brain. The international journal of neuropsychopharmacology 20020601
Extended action of MKC-242, a selective 5-HT(1A) receptor agonist, on light-induced Per gene expression in the suprachiasmatic nucleus in mice. Journal of neuroscience research 20020515
Tandospirone potentiates the fluoxetine-induced increases in extracellular dopamine via 5-HT(1A) receptors in the rat medial frontal cortex. Neurochemistry international 20020401
Hypomania induced by herbal and pharmaceutical psychotropic medicines following mild traumatic brain injury. Brain injury 20020401
Contact leukoderma caused by buspirone patches. American journal of contact dermatitis : official journal of the American Contact Dermatitis Society 20020301
[Buspirone increases D2-like dopaminergic receptor density in rat corpus striatum]. Arquivos de neuro-psiquiatria 20020301
Benzodiazepine discontinuation in generalized anxiety disorder. The American journal of psychiatry 20020201
Acute buspirone abolishes the expression of behavioral dopaminergic supersensitivity in mice. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20020201
Bupropion-induced acute dystonia. The Annals of pharmacotherapy 20020201
Olfactory-mediated fear-potentiated startle. Behavioral neuroscience 20020201
Pharmacological and endocrinological characterisation of stress-induced hyperthermia in singly housed mice using classical and candidate anxiolytics (LY314582, MPEP and NKP608). European journal of pharmacology 20020125
Short term aerobic exercise training in young males does not alter sensitivity to a central serotonin agonist. Experimental physiology 20020101
Seed finding in golden hamsters: a potential animal model for screening anxiolytic drugs. Neuropsychobiology 20020101
Treatment of generalized anxiety disorder. The Journal of clinical psychiatry 20020101
Marked suppression of gastric ulcerogenesis and intestinal responses to stress by a novel class of drugs. Molecular psychiatry 20020101
Generalised anxiety disorder: treatment options. Drugs 20020101
Pharmacotherapy of generalized anxiety disorder. The Journal of clinical psychiatry 20020101
13C cpmas nmr and molecular modeling in the studies of new analogues of buspirone. Acta poloniae pharmaceutica 20020101
Effects of cholecystokinin tetrapeptide (CCK(4)) and anxiolytic drugs on the electrically evoked [(3)H]5-hydroxytryptamine outflow from rat cortical slices. Brain research 20011213
Pharmacokinetics and tolerability of buspirone during oral administration to children and adolescents with anxiety disorder and normal healthy adults. Journal of clinical pharmacology 20011201
Astrocyte-mediated trophic support of developing serotonin neurons: effects of ethanol, buspirone, and S100B. Brain research. Developmental brain research 20011126
Buspirone and meperidine synergistically reduce the shivering threshold. Anesthesia and analgesia 20011101
Quantifying the 5-HT1A agonist action of buspirone in man. Psychopharmacology 20011101
Acoustic startle, conditioned startle potentiation and the effects of 8-OH-DPAT and buspirone in rats selectively bred for differences in 8-OH-DPAT-induced hypothermia. Behavioural pharmacology 20011101
Pattern of symptom improvement following treatment with venlafaxine XR in patients with generalized anxiety disorder. The Journal of clinical psychiatry 20011101
Molecular dynamics of 5-HT1A and 5-HT2A serotonin receptors with methylated buspirone analogues. Journal of computer-aided molecular design 20011101
Impact of cortisol on buspirone stimulated prolactin release: a double-blind placebo-controlled study. Psychoneuroendocrinology 20011001
Small platform stress increases exploratory activity of mice in staircase test. Progress in neuro-psychopharmacology & biological psychiatry 20011001
A double-blind placebo-controlled study of buspirone-stimulated prolactin release in non-ulcer dyspepsia--are central serotoninergic responses enhanced? Alimentary pharmacology & therapeutics 20011001
The effect of glucocorticoids on the anxiolytic efficacy of buspirone. Psychopharmacology 20011001
Diazepam, but not buspirone, induces similar anxiolytic-like actions in lactating and ovariectomized Wistar rats. Pharmacology, biochemistry, and behavior 20010901
Effectiveness of pharmacotherapy for body dysmorphic disorder: a chart-review study. The Journal of clinical psychiatry 20010901
An open study of buspirone augmentation of neuroleptics in patients with schizophrenia. Journal of clinical psychopharmacology 20010801
Ataxia from lithium toxicity successfully treated with high-dose buspirone: a single-case experimental design. Archives of physical medicine and rehabilitation 20010801
A comparative multidose pharmacokinetic study of buspirone extended-release tablets with a reference immediate-release product. Journal of clinical pharmacology 20010801
Switching from benzodiazepines to buspirone using a tapered overlap method in generalized anxiety disorder. The Journal of clinical psychiatry 20010801
[Permeation of buspirone hydrochloride across animal buccal mucosa and its mechanism]. Yao xue xue bao = Acta pharmaceutica Sinica 20010801
Characterization of alpha1-adrenoceptor-mediated contraction in the mouse thoracic aorta. European journal of pharmacology 20010720
Serotonin-based pharmacotherapy for acute neuroleptic-induced akathisia: a new approach to an old problem. The British journal of psychiatry : the journal of mental science 20010701
Late-onset bipolar disorder due to hyperthyroidism. Acta psychiatrica Scandinavica 20010701
Common effects of chronically administered antipanic drugs on brainstem GABA(A) receptor subunit gene expression. Molecular psychiatry 20010701
Pharmacokinetics of buspirone extended-release tablets: a single-dose study. Journal of clinical pharmacology 20010701
An open trial of divalproex sodium in autism spectrum disorders. The Journal of clinical psychiatry 20010701
Potential involvement of S100B in the protective effects of a serotonin-1a agonist on ethanol-treated astrocytes. Brain research. Developmental brain research 20010629
SSRI discontinuation and buspirone. The American journal of psychiatry 20010601
Patients with severe depression may benefit from buspirone augmentation of selective serotonin reuptake inhibitors: results from a placebo-controlled, randomized, double-blind, placebo wash-in study. The Journal of clinical psychiatry 20010601
An investigation of the mechanisms responsible for acute fluoxetine-induced anxiogenic-like effects in mice. Behavioural pharmacology 20010601
5-HT1A receptor activation and antidepressant-like effects: F 13714 has high efficacy and marked antidepressant potential. European journal of pharmacology 20010525
Biochemical, electrophysiological and neurohormonal studies with B-20991, a selective 5-HT1A receptor agonist. Pharmacology 20010501
Quantifying drug-related 5-HT1A receptor occupancy with. Psychopharmacology 20010501
Compounds with affinity for serotonergic receptors in the treatment of premenstrual dysphoria: a comparison of buspirone, nefazodone and placebo. Psychopharmacology 20010501
Does pretreatment anxiety predict response to either bupropion SR or sertraline? Journal of affective disorders 20010401
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