200,000+ products from a single source!
sales@angenechem.com
329-89-5 | 6-Aminonicotinamide
CAS No: 329-89-5 Catalog No: AG003N2V MDL No:MFCD00006327
Product Description
Catalog Number:
AG003N2V
Chemical Name:
6-Aminonicotinamide
CAS Number:
329-89-5
Molecular Formula:
C6H7N3O
Molecular Weight:
137.1393
MDL Number:
MFCD00006327
IUPAC Name:
6-aminopyridine-3-carboxamide
InChI:
InChI=1S/C6H7N3O/c7-5-2-1-4(3-9-5)6(8)10/h1-3H,(H2,7,9)(H2,8,10)
InChI Key:
ZLWYEPMDOUQDBW-UHFFFAOYSA-N
SMILES:
Nc1ccc(cn1)C(=O)N
EC Number:
206-349-7
UNII:
D6FNW67F2B
NSC Number:
21206
Properties
Complexity:
137
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
137.059g/mol
Formal Charge:
0
Heavy Atom Count:
10
Hydrogen Bond Acceptor Count:
3
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
137.142g/mol
Monoisotopic Mass:
137.059g/mol
Rotatable Bond Count:
1
Topological Polar Surface Area:
82A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
0.7
Literature
| Title | Journal |
|---|---|
| Glycogen synthase kinase 3 regulates cell death and survival signaling in tumor cells under redox stress. | Neoplasia (New York, N.Y.) 20140901 |
| A high-throughput screen for teratogens using human pluripotent stem cells. | Toxicological sciences : an official journal of the Society of Toxicology 20140101 |
| 2-Deoxy-D-glucose and 6-aminonicotinamide-mediated Nrf2 down regulation leads to radiosensitization of malignant cells via abrogation of GSH-mediated defense. | Free radical research 20121201 |
| Radiosensitization by 2-deoxy-D-glucose and 6-aminonicotinamide involves activation of redox sensitive ASK1-JNK/p38MAPK signaling in head and neck cancer cells. | Free radical biology & medicine 20121001 |
| A combination of 2-deoxy-D-glucose and 6-aminonicotinamide induces cell cycle arrest and apoptosis selectively in irradiated human malignant cells. | Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20120801 |
| 6-Amino-nicotinamide. | Acta crystallographica. Section E, Structure reports online 20120801 |
| Establishment of a novel fluorescence-based method to evaluate chaperone-mediated autophagy in a single neuron. | PloS one 20120101 |
| JC virus T-antigen regulates glucose metabolic pathways in brain tumor cells. | PloS one 20120101 |
| Activation of β-catenin by oncogenic PIK3CA and EGFR promotes resistance to glucose deprivation by inducing a strong antioxidant response. | PloS one 20120101 |
| Glucose-6-phosphate dehydrogenase and NADPH redox regulates cardiac myocyte L-type calcium channel activity and myocardial contractile function. | PloS one 20120101 |
| NADPH oxidase activation by hyperglycaemia in cardiomyocytes is independent of glucose metabolism but requires SGLT1. | Cardiovascular research 20111101 |
| A combination of 2-deoxy-D-glucose and 6-aminonicotinamide induces oxidative stress mediated selective radiosensitization of malignant cells via mitochondrial dysfunction. | Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20111001 |
| Dehydroepiandrosterone inhibits glucose flux through the pentose phosphate pathway in human and mouse endometrial stromal cells, preventing decidualization and implantation. | Molecular endocrinology (Baltimore, Md.) 20110801 |
| Controlled release of 6-aminonicotinamide from aligned, electrospun fibers alters astrocyte metabolism and dorsal root ganglia neurite outgrowth. | Journal of neural engineering 20110801 |
| Apoptosis induced by overall metabolic stress converges on the Bcl-2 family proteins Noxa and Mcl-1. | Apoptosis : an international journal on programmed cell death 20110701 |
| Mechanism of glucose-6-phosphate dehydrogenase-mediated regulation of coronary artery contractility. | American journal of physiology. Heart and circulatory physiology 20110601 |
| The embryonic stem cell test as tool to assess structure-dependent teratogenicity: the case of valproic acid. | Toxicological sciences : an official journal of the Society of Toxicology 20110401 |
| Redox signaling in cardiac myocytes. | Free radical biology & medicine 20110401 |
| The CNS microvascular pericyte: pericyte-astrocyte crosstalk in the regulation of tissue survival. | Fluids and barriers of the CNS 20110101 |
| Stereocomplexes Formed From Select Oligomers of Polymer d-lactic Acid (PDLA) and l-lactate May Inhibit Growth of Cancer Cells and Help Diagnose Aggressive Cancers-Applications of the Warburg Effect. | Perspectives in medicinal chemistry 20110101 |
| A review of metallothionein isoforms and their role in pathophysiology. | World journal of surgical oncology 20110101 |
| IGF-1 induction by acylated steryl β-glucosides found in a pre-germinated brown rice diet reduces oxidative stress in streptozotocin-induced diabetes. | PloS one 20110101 |
| Teratogen-induced oxidative stress targets glyceraldehyde-3-phosphate dehydrogenase in the organogenesis stage mouse embryo. | Toxicological sciences : an official journal of the Society of Toxicology 20101201 |
| Metabolic oxidative stress induced by a combination of 2-DG and 6-AN enhances radiation damage selectively in malignant cells via non-coordinated expression of antioxidant enzymes. | Cancer letters 20100928 |
| Genes, environment, and orofacial clefting: N-acetyltransferase and folic acid. | The Journal of craniofacial surgery 20100901 |
| Delineating biological pathways unique to embryonic stem cell-derived insulin-producing cell lines from their noninsulin-producing progenitor cell lines. | Endocrinology 20100801 |
| Glucose is necessary for stabilization of hypoxia-inducible factor-1alpha under hypoxia: contribution of the pentose phosphate pathway to this stabilization. | FEBS letters 20100716 |
| Transcriptomics-based identification of developmental toxicants through their interference with cardiomyocyte differentiation of embryonic stem cells. | Toxicology and applied pharmacology 20100315 |
| DCB-3503, a tylophorine analog, inhibits protein synthesis through a novel mechanism. | PloS one 20100101 |
| Disentangling cellular proliferation and differentiation in the embryonic stem cell test, and its impact on the experimental protocol. | Reproductive toxicology (Elmsford, N.Y.) 20090901 |
| Glucose regulated protein 78 prompts scavenger receptor A-mediated secretion of tumor necrosis factor-α by RAW 264.7 cells. | Clinical and experimental pharmacology & physiology 20090901 |
| Synergistic activation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase by Src kinase elevates superoxide in type 2 diabetic, Zucker fa/fa, rat liver. | Free radical biology & medicine 20090801 |
| Reactive oxygen species-independent oxidation of thioredoxin in hypoxia: inactivation of ribonucleotide reductase and redox-mediated checkpoint control. | The Journal of biological chemistry 20090619 |
| A new strategy to improve the efficiency and sustainability of Candida parapsilosis catalyzing deracemization of (R,S)-1-phenyl-1,2-ethanediol under non-growing conditions: increase of NADPH availability. | Journal of microbiology and biotechnology 20090101 |
| Altering chemosensitivity by modulating translation elongation. | PloS one 20090101 |
| Automated analysis of contractility in the embryonic stem cell test, a novel approach to assess embryotoxicity. | Toxicology in vitro : an international journal published in association with BIBRA 20081201 |
| Evaluation of the embryotoxic potency of compounds in a newly revised high throughput embryonic stem cell test. | Toxicological sciences : an official journal of the Society of Toxicology 20081001 |
| Confirmation of the role of N-acetyltransferase 2 in teratogen-induced cleft palate using transgenics and knockouts. | Molecular reproduction and development 20080601 |
| Oxidative pentose phosphate pathway-dependent sugar sensing as a mechanism for regulation of root ion transporters by photosynthesis. | Plant physiology 20080401 |
| 1-Methylnicotinamide and nicotinamide: two related anti-inflammatory agents that differentially affect the functions of activated macrophages. | Archivum immunologiae et therapiae experimentalis 20080401 |
| The role of multiple drug resistance proteins in fetal and/or placental protection against teratogen-induced orofacial clefting. | Molecular reproduction and development 20071101 |
| The discovery of 6-amino nicotinamides as potent and selective histone deacetylase inhibitors. | Bioorganic & medicinal chemistry letters 20071001 |
| Pro-inflammatory cytokines increase reactive oxygen species through mitochondria and NADPH oxidase in cultured RPE cells. | Experimental eye research 20071001 |
| Upregulation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase activity increases oxidative stress in failing human heart. | Journal of cardiac failure 20070801 |
| The effect of glucose on the progression of the nuclear maturation of pig oocytes. | Animal reproduction science 20070601 |
| Protection by 6-aminonicotinamide against oxidative stress in cardiac cells. | Pharmacological research 20061001 |
| Glucose-6-phosphate dehydrogenase-derived NADPH fuels superoxide production in the failing heart. | Journal of molecular and cellular cardiology 20060801 |
| Hypoxia promotes relaxation of bovine coronary arteries through lowering cytosolic NADPH. | American journal of physiology. Heart and circulatory physiology 20060601 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| Metallothionein I + II expression and roles during neuropathology in the CNS. | Danish medical bulletin 20060501 |
| Thiol oxidation inhibits nitric oxide-mediated pulmonary artery relaxation and guanylate cyclase stimulation. | American journal of physiology. Lung cellular and molecular physiology 20060301 |
| Role of pentose phosphate pathway-derived NADPH in hypoxic pulmonary vasoconstriction. | Pulmonary pharmacology & therapeutics 20060101 |
| The Balance between Life and Death of Cells: Roles of Metallothioneins. | Biomarker insights 20060101 |
| Effects of D-glucose concentration, D-fructose, and inhibitors of enzymes of the pentose phosphate pathway on the development and sex ratio of bovine blastocysts. | Molecular reproduction and development 20051001 |
| Fetal hydrocephalus, intrauterine diagnosis and therapy considerations: an experimental rat model. | Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 20050501 |
| Radiosensitization by 6-aminonicotinamide and 2-deoxy-D-glucose in human cancer cells. | International journal of radiation biology 20050501 |
| Involvement of the pentose phosphate pathway and redox regulation in fertilization in the mouse. | Molecular reproduction and development 20050401 |
| Correlation of susceptibility to 6-aminonicotinamide and hydrocortisone-induced cleft palate. | Life sciences 20050318 |
| Cytosolic NADPH may regulate differences in basal Nox oxidase-derived superoxide generation in bovine coronary and pulmonary arteries. | American journal of physiology. Heart and circulatory physiology 20050101 |
| Metallothionein mediates leukocyte chemotaxis. | BMC immunology 20050101 |
| Effects of small molecules on chaperone-mediated autophagy. | Autophagy 20050101 |
| Radiosensitization of murine Ehrlich ascites tumor by a combination of 2-deoxy-D-glucose and 6-aminonicotinamide. | Technology in cancer research & treatment 20041201 |
| Discriminative power of an assay for automated in vitro screening of teratogens. | Toxicology in vitro : an international journal published in association with BIBRA 20040801 |
| Metallothionein prevents neurodegeneration and central nervous system cell death after treatment with gliotoxin 6-aminonicotinamide. | Journal of neuroscience research 20040701 |
| Effects of oxidative stress and inhibitors of the pentose phosphate pathway on sexually dimorphic production of IFN-tau by bovine blastocysts. | Molecular reproduction and development 20040501 |
| Inhibition of the pentose phosphate pathway decreases ischemia-reperfusion-induced creatine kinase release in the heart. | Cardiovascular research 20040401 |
| Comparative sensitivity of Xenopus tropicalis and Xenopus laevis as test species for the FETAX model. | Journal of applied toxicology : JAT 20040101 |
| Insulin stimulates glucose metabolism via the pentose phosphate pathway in Drosophila Kc cells. | FEBS letters 20031204 |
| Pentose phosphate pathway coordinates multiple redox-controlled relaxing mechanisms in bovine coronary arteries. | American journal of physiology. Heart and circulatory physiology 20031201 |
| Contribution of oxidative stress to radiosensitization by a combination of 2-DG and 6-AN in human cancer cell line. | Indian journal of experimental biology 20031201 |
| Effects of 6-aminonicotinamide gliotoxin on blood-brain barrier differentiation in the chick embryo cerebellum. | Anatomy and embryology 20031001 |
| Astrocyte-targeted expression of interleukin-6 protects the central nervous system during neuroglial degeneration induced by 6-aminonicotinamide. | Journal of neuroscience research 20030815 |
| Evaluation of Xenopus tropicalis as an alternative test organism for frog embryo teratogenesis assay--Xenopus (FETAX). | Drug and chemical toxicology 20030801 |
| Up-regulation of glucose metabolism during male pronucleus formation determines the early onset of the s phase in bovine zygotes. | Biology of reproduction 20030501 |
| Down-regulation of topoisomerase II alpha is caused by up-regulation of GRP78. | Biochemical and biophysical research communications 20030110 |
| A model of the oscillatory metabolism of activated neutrophils. | Biophysical journal 20030101 |
| A functional observational battery for use in canine toxicity studies: development and validation. | International journal of toxicology 20030101 |
| Energy metabolism and cerebral blood flow during cytotoxic brain edema induced by 6-aminonicotinamide. | Acta neurochirurgica. Supplement 20030101 |
| Monitoring flux through the oxidative pentose phosphate pathway using [1-14C]gluconate. | Planta 20021201 |
| Effects of ATP on the stability of enzymes against heat treatment in 6-aminonicotinamide treated quail. | The international journal of biochemistry & cell biology 20020901 |
| Frozen-sectioning yields similar results as traditional methods for fetal cephalic examination in the rat. | Teratology 20020801 |
| M-CSF deficiency leads to reduced metallothioneins I and II expression and increased tissue damage in the brain stem after 6-aminonicotinamide treatment. | Experimental neurology 20020801 |
| Inhibitors of pentose phosphate pathway cause vasodilation: involvement of voltage-gated potassium channels. | The Journal of pharmacology and experimental therapeutics 20020401 |
| Metallothionein 1+2 protect the CNS during neuroglial degeneration induced by 6-aminonicotinamide. | The Journal of comparative neurology 20020305 |
| Selection of test chemicals for the ECVAM international validation study on in vitro embryotoxicity tests. European Centre for the Validation of Alternative Methods. | Alternatives to laboratory animals : ATLA 20020101 |
| Effects of neurotoxin 6-aminonicotinamide on levels of enzyme activities and metabolites in quail plasma. | The international journal of biochemistry & cell biology 20010601 |
| IL-6 deficiency leads to reduced metallothionein-I+II expression and increased oxidative stress in the brain stem after 6-aminonicotinamide treatment. | Experimental neurology 20000501 |
| Efficacy of 101 antimicrobials and other agents on the development of Cryptosporidium parvum in vitro. | Annals of tropical medicine and parasitology 19961201 |
| Major effects on teratogen-induced facial clefting in mice determined by a single genetic region. | Genetics 19900901 |
Related Products
Featured Products
© 2019 Angene International Limited. All rights Reserved.