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Home > Other Building Blocks > 3206-73-3
3206-73-3 | DL-5-(1,2-Dithiolan-3-yl)valeramide
CAS No: 3206-73-3 Catalog No: AG003PT7 MDL No:
Product Description
Catalog Number:
AG003PT7
Chemical Name:
DL-5-(1,2-Dithiolan-3-yl)valeramide
CAS Number:
3206-73-3
IUPAC Name:
5-(dithiolan-3-yl)pentanamide
InChI:
InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10)
InChI Key:
FCCDDURTIIUXBY-UHFFFAOYSA-N
Properties
Complexity:
152
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
205.06g/mol
Formal Charge:
0
Heavy Atom Count:
12
Hydrogen Bond Acceptor Count:
3
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
205.334g/mol
Monoisotopic Mass:
205.06g/mol
Rotatable Bond Count:
5
Topological Polar Surface Area:
93.7A^2
Undefined Atom Stereocenter Count:
1
Undefined Bond Stereocenter Count:
0
XLogP3:
1
Literature
| Title | Journal |
|---|---|
| Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase. | Biochemistry 20131223 |
| Radical reactions of thiamin pyrophosphate in 2-oxoacid oxidoreductases. | Biochimica et biophysica acta 20121101 |
| Mutations in BCKD-kinase lead to a potentially treatable form of autism with epilepsy. | Science (New York, N.Y.) 20121019 |
| Neuroscience. Preventable forms of autism? | Science (New York, N.Y.) 20121019 |
| Pyruvate dehydrogenase complex: mRNA and protein expression patterns of E1α subunit genes in human spermatogenesis. | Gene 20120910 |
| In situ regeneration of NADH via lipoamide dehydrogenase-catalyzed electron transfer reaction evidenced by spectroelectrochemistry. | Bioelectrochemistry (Amsterdam, Netherlands) 20120801 |
| Quantitative imaging of electron transfer flavoprotein autofluorescence reveals the dynamics of lipid partitioning in living pancreatic islets. | Integrative biology : quantitative biosciences from nano to macro 20120801 |
| Mapping an X-linked locus that influences heat-induced febrile seizures in mice. | Epilepsia 20120801 |
| Tissue-specific and nutrient regulation of the branched-chain α-keto acid dehydrogenase phosphatase, protein phosphatase 2Cm (PP2Cm). | The Journal of biological chemistry 20120706 |
| Prospective study of changes in the metabolomic profiles of men during their first three months of androgen deprivation therapy for prostate cancer. | Clinical cancer research : an official journal of the American Association for Cancer Research 20120701 |
| Thiamine and Parkinson's disease. | Journal of the neurological sciences 20120515 |
| A case of pyruvate dehydrogenase E1α subunit deficiency with antenatal brain dysgenesis demonstrated by prenatal sonography and magnetic resonance imaging. | Journal of clinical ultrasound : JCU 20120501 |
| Unilateral periventricular leukomalacia in association with pyruvate dehydrogenase deficiency. | Developmental medicine and child neurology 20120501 |
| Intermittent-relapsing pyruvate dehydrogenase complex deficiency: a case with clinical, biochemical, and neuroradiological reversibility. | Developmental medicine and child neurology 20120501 |
| Pyruvate dehydrogenase deficiency and the brain. | Developmental medicine and child neurology 20120501 |
| Two novel mutations in the BCKDHB gene (R170H, Q346R) cause the classic form of maple syrup urine disease (MSUD). | Gene 20120425 |
| Predicting the fission yeast protein interaction network. | G3 (Bethesda, Md.) 20120401 |
| Probing lactate dehydrogenase activity in tumors by measuring hydrogen/deuterium exchange in hyperpolarized l-[1-(13)C,U-(2)H]lactate. | Journal of the American Chemical Society 20120314 |
| Beneficial effect of pyruvate therapy on Leigh syndrome due to a novel mutation in PDH E1α gene. | Brain & development 20120201 |
| A-MYB (MYBL1) stimulates murine testis-specific Ldhc expression via the cAMP-responsive element (CRE) site. | Biology of reproduction 20120201 |
| Five new amicoumacins isolated from a marine-derived bacterium Bacillus subtilis. | Marine drugs 20120201 |
| Contrasting effects of selenite and tellurite on lipoamide dehydrogenase activity suggest a different biological behaviour of the two chalcogens. | Archives of biochemistry and biophysics 20120101 |
| Mitochondria-ros crosstalk in the control of cell death and aging. | Journal of signal transduction 20120101 |
| Differential expression of iron acquisition genes by Brucella melitensis and Brucella canis during macrophage infection. | PloS one 20120101 |
| Differences in nitrogen metabolism between Cryptococcus neoformans and C. gattii, the two etiologic agents of cryptococcosis. | PloS one 20120101 |
| Understanding delayed T-cell priming, lung recruitment, and airway luminal T-cell responses in host defense against pulmonary tuberculosis. | Clinical & developmental immunology 20120101 |
| Demethylation of the coding region triggers the activation of the human testis-specific PDHA2 gene in somatic tissues. | PloS one 20120101 |
| Arsenic toxicity: the effects on plant metabolism. | Frontiers in physiology 20120101 |
| Analysis of the organic hydroperoxide response of Chromobacterium violaceum reveals that OhrR is a cys-based redox sensor regulated by thioredoxin. | PloS one 20120101 |
| Lipoic acid synthetase deficiency causes neonatal-onset epilepsy, defective mitochondrial energy metabolism, and glycine elevation. | American journal of human genetics 20111209 |
| Molecular characterization of 82 patients with pyruvate dehydrogenase complex deficiency. Structural implications of novel amino acid substitutions in E1 protein. | Molecular genetics and metabolism 20111201 |
| Activation of α-keto acid-dependent dioxygenases: application of an {FeNO}7/{FeO2}8 methodology for characterizing the initial steps of O2 activation. | Journal of the American Chemical Society 20111116 |
| AMP-activated protein kinase and metabolic regulation in cold-hardy insects. | Journal of insect physiology 20111101 |
| Mapping the lipoylation site of Arabidopsis thaliana plastidial dihydrolipoamide S-acetyltransferase using mass spectrometry and site-directed mutagenesis. | Plant physiology and biochemistry : PPB 20111101 |
| Increased superoxide accumulation in pyruvate dehydrogenase complex deficient fibroblasts. | Molecular genetics and metabolism 20111101 |
| Emerging perspectives on essential amino acid metabolism in obesity and the insulin-resistant state. | Advances in nutrition (Bethesda, Md.) 20111101 |
| Dihydroquinazolines as a novel class of Trypanosoma brucei trypanothione reductase inhibitors: discovery, synthesis, and characterization of their binding mode by protein crystallography. | Journal of medicinal chemistry 20111013 |
| Growth factor withdrawal in combination with sodium butyrate addition extends culture longevity and enhances antibody production in CHO cells. | Journal of biotechnology 20110910 |
| Use of the valine biosynthetic pathway to convert glucose into isobutanol. | Journal of industrial microbiology & biotechnology 20110901 |
| Exercise-induced pyruvate dehydrogenase activation is not affected by 7 days of bed rest. | Journal of applied physiology (Bethesda, Md. : 1985) 20110901 |
| [Role of lipoic acid in health and disease]. | Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20110901 |
| Differential expression of Trypanosoma cruzi I associated with clinical forms of Chagas disease: overexpression of oxidative stress proteins in acute patient isolate. | Journal of proteomics 20110824 |
| Mycobacterium tuberculosislpdC, Rv0462, induces dendritic cell maturation and Th1 polarization. | Biochemical and biophysical research communications 20110805 |
| Stimulation of reactive oxygen species generation by disease-causing mutations of lipoamide dehydrogenase. | Human molecular genetics 20110801 |
| Lipoamide dehydrogenase is essential for both bloodstream and procyclic Trypanosoma brucei. | Molecular microbiology 20110801 |
| Lipoic acid stimulates cAMP production via G protein-coupled receptor-dependent and -independent mechanisms. | The Journal of nutritional biochemistry 20110701 |
| MRI features of 4 female patients with pyruvate dehydrogenase E1 alpha deficiency. | Pediatric neurology 20110701 |
| Glycine cleavage enzyme complex: molecular cloning and expression of the H-protein cDNA from cultured human skin fibroblasts. | Biochemistry and cell biology = Biochimie et biologie cellulaire 20110601 |
| Detection of DNA hybridisation in a diluted serum matrix by surface plasmon resonance and film bulk acoustic resonators. | Analytical and bioanalytical chemistry 20110501 |
| Substrate and inhibitor specificities differ between human cytosolic and mitochondrial thioredoxin reductases: Implications for development of specific inhibitors. | Free radical biology & medicine 20110315 |
| Overexpression of alpha-ketoglutarate dehydrogenase in Yarrowia lipolytica and its effect on production of organic acids. | Applied microbiology and biotechnology 20110301 |
| Lipoamide or lipoic acid stimulates mitochondrial biogenesis in 3T3-L1 adipocytes via the endothelial NO synthase-cGMP-protein kinase G signalling pathway. | British journal of pharmacology 20110301 |
| A high-fat diet elicits differential responses in genes coordinating oxidative metabolism in skeletal muscle of lean and obese individuals. | The Journal of clinical endocrinology and metabolism 20110301 |
| In vivo neuroprotective effect of L-carnitine against oxidative stress in maple syrup urine disease. | Metabolic brain disease 20110301 |
| Phenylbutyrate therapy for maple syrup urine disease. | Human molecular genetics 20110215 |
| Successful TAT-mediated enzyme replacement therapy in a mouse model of mitochondrial E3 deficiency. | Journal of molecular medicine (Berlin, Germany) 20110201 |
| Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes. | Cell host & microbe 20110120 |
| Toxin-induced and genetic animal models of Parkinson's disease. | Parkinson's disease 20110101 |
| Mitochondrial dysfunction in Parkinson's disease: pathogenesis and neuroprotection. | Parkinson's disease 20110101 |
| Animal products, diseases and drugs: a plea for better integration between agricultural sciences, human nutrition and human pharmacology. | Lipids in health and disease 20110101 |
| Obesity resistant mechanisms in the Lean polygenic mouse model as indicated by liver transcriptome and expression of selected genes in skeletal muscle. | BMC genomics 20110101 |
| Lipoic acid: energy metabolism and redox regulation of transcription and cell signaling. | Journal of clinical biochemistry and nutrition 20110101 |
| Genomic stability over 9 years of an isoniazid resistant Mycobacterium tuberculosis outbreak strain in Sweden. | PloS one 20110101 |
| The self-organizing fractal theory as a universal discovery method: the phenomenon of life. | Theoretical biology & medical modelling 20110101 |
| Modulation of gene expression in heart and liver of hibernating black bears (Ursus americanus). | BMC genomics 20110101 |
| Two patients with clinically distinct manifestation of pyruvate dehydrogenase deficiency due to mutations in PDHA1 gene. | Prague medical report 20110101 |
| Zinc oxide nanoparticles as selective killers of proliferating cells. | International journal of nanomedicine 20110101 |
| VapC toxins from Mycobacterium tuberculosis are ribonucleases that differentially inhibit growth and are neutralized by cognate VapB antitoxins. | PloS one 20110101 |
| Three Korean patients with maple syrup urine disease: four novel mutations in the BCKDHA gene. | Annals of clinical and laboratory science 20110101 |
| An Examination by Site-Directed Mutagenesis of Putative Key Residues in the Determination of Coenzyme Specificity in Clostridial NAD-Dependent Glutamate Dehydrogenase. | Enzyme research 20110101 |
| Brain region specific mitophagy capacity could contribute to selective neuronal vulnerability in Parkinson's disease. | Proteome science 20110101 |
| Novel Conjugates of 1,3-Diacylglycerol and Lipoic Acid: Synthesis, DPPH Assay, and RP-LC-MS-APCI Analysis. | Journal of lipids 20110101 |
| Critical assessment of human metabolic pathway databases: a stepping stone for future integration. | BMC systems biology 20110101 |
| Serine biosynthesis with one carbon catabolism and the glycine cleavage system represents a novel pathway for ATP generation. | PloS one 20110101 |
| Structural-functional characterization and physiological significance of ferredoxin-NADP reductase from Xanthomonas axonopodis pv. citri. | PloS one 20110101 |
| Diabetes and alpha lipoic Acid. | Frontiers in pharmacology 20110101 |
| Identification of two novel BCKDHA mutations in a Chinese patient with maple syrup urine disease. | Journal of pediatric endocrinology & metabolism : JPEM 20110101 |
| Radiation-induced signaling results in mitochondrial impairment in mouse heart at 4 weeks after exposure to X-rays. | PloS one 20110101 |
| Dietary lipoic acid influences antioxidant capability and oxidative status of broilers. | International journal of molecular sciences 20110101 |
| Nutrigenetics, nutrigenomics, and selenium. | Frontiers in genetics 20110101 |
| Functional proteomic analysis for regulatory T cell surveillance of the HIV-1-infected macrophage. | Journal of proteome research 20101203 |
| Is it time to reassess alpha lipoic acid and niacinamide therapy in schizophrenia? | Medical hypotheses 20101201 |
| PGC-1alpha increases PDH content but does not change acute PDH regulation in mouse skeletal muscle. | American journal of physiology. Regulatory, integrative and comparative physiology 20101101 |
| Liver-specific pyruvate dehydrogenase complex deficiency upregulates lipogenesis in adipose tissue and improves peripheral insulin sensitivity. | Lipids 20101101 |
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
| Deletion at chromosomal band Xp22.12-Xp22.13 involving PDHA1 in a patient with congenital lactic acidosis. | Molecular genetics and metabolism 20100901 |
| Improved functionality of antibody-colloidal gold conjugates with the aid of lipoamide-grafted N-[tris(hydroxymethyl)methyl]acrylamide polymers. | Journal of colloid and interface science 20100801 |
| A stable and controllable Prussian blue layer electrodeposited on self-assembled monolayers for constructing highly sensitive glucose biosensor. | The Analyst 20100801 |
| Somatic mosaicism for PDHA1 mutation in a male with pyruvate dehydrogenase complex deficiency. | Molecular genetics and metabolism 20100701 |
| Disruption of ptLPD1 or ptLPD2, genes that encode isoforms of the plastidial lipoamide dehydrogenase, confers arsenate hypersensitivity in Arabidopsis. | Plant physiology 20100701 |
| A technical surgery for refractory gastroparesis in a patient with a mitochondrial disorder. | Pediatric surgery international 20100601 |
| Solution structure and characterisation of the human pyruvate dehydrogenase complex core assembly. | Journal of molecular biology 20100528 |
| Mutational study in the PDHA1 gene of 40 patients suspected of pyruvate dehydrogenase complex deficiency. | Clinical genetics 20100501 |
| A combination of alpha lipoic acid and calcium hydroxycitrate is efficient against mouse cancer models: preliminary results. | Oncology reports 20100501 |
| Protection by Exogenously Added Coenzyme Q(9) against Free Radical-Induced Injuries in Human Liver Cells. | Journal of clinical biochemistry and nutrition 20100501 |
| Communication between thiamin cofactors in the Escherichia coli pyruvate dehydrogenase complex E1 component active centers: evidence for a 'direct pathway' between the 4'-aminopyrimidine N1' atoms. | The Journal of biological chemistry 20100409 |
| Human testis-specific PDHA2 gene: methylation status of a CpG island in the open reading frame correlates with transcriptional activity. | Molecular genetics and metabolism 20100401 |
| Analysis of branched-chain alpha-keto acid dehydrogenase complex activity in rat tissues using alpha-keto[1-13C]isocaproate as substrate. | Analytical biochemistry 20100401 |
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| The effects of branched-chain amino acid interactions on growth performance, blood metabolites, enzyme kinetics and transcriptomics in weaned pigs. | The British journal of nutrition 20100401 |
| Triazaspirodimethoxybenzoyls as selective inhibitors of mycobacterial lipoamide dehydrogenase . | Biochemistry 20100302 |
| Transhydrogenase and the anaerobic mitochondrial metabolism of adult Hymenolepis diminuta. | Parasitology 20100301 |
| Gene cloning and characterization of dihydrolipoamide dehydrogenase from Microbacterium luteolum: A useful enzymatic regeneration system of NAD+ from NADH. | Journal of bioscience and bioengineering 20100301 |
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| Multiple roles of PPARalpha in brown adipose tissue under constitutive and cold conditions. | Genes to cells : devoted to molecular & cellular mechanisms 20100201 |
| Plasmodium pyruvate dehydrogenase activity is only essential for the parasite's progression from liver infection to blood infection. | Molecular microbiology 20100201 |
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| Characterization of a dihydrolipoyl dehydrogenase having diaphorase activity of Clostridium kluyveri. | Bioscience, biotechnology, and biochemistry 20080401 |
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| The two active sites in human branched-chain alpha-keto acid dehydrogenase operate independently without an obligatory alternating-site mechanism. | The Journal of biological chemistry 20070420 |
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| A family with pyruvate dehydrogenase complex deficiency due to a novel C>T substitution at nucleotide position 407 in exon 4 of the X-linked Epsilon1alpha gene. | European journal of pediatrics 20050201 |
| Precursor and temperature modulation of fatty acid composition and growth of Listeria monocytogenes cold-sensitive mutants with transposon-interrupted branched-chain alpha-keto acid dehydrogenase. | Microbiology (Reading, England) 20050201 |
| Short-term feeding of fish oil down-regulates the expression of pyruvate dehydrogenase E1 alpha subunit mRNA in mouse brain. | Bioscience, biotechnology, and biochemistry 20050201 |
| Dissociation of branched-chain alpha-keto acid dehydrogenase kinase (BDK) from branched-chain alpha-keto acid dehydrogenase complex (BCKDC) by BDK inhibitors. | Journal of nutritional science and vitaminology 20050201 |
| The human malaria parasite Plasmodium falciparum possesses two distinct dihydrolipoamide dehydrogenases. | Molecular microbiology 20050101 |
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| Crystal structure of T-protein of the glycine cleavage system. Cofactor binding, insights into H-protein recognition, and molecular basis for understanding nonketotic hyperglycinemia. | The Journal of biological chemistry 20041126 |
| Deficiency of pyruvate dehydrogenase caused by novel and known mutations in the E1alpha subunit. | American journal of medical genetics. Part A 20041115 |
| Amino-terminal residues 1-45 of the Escherichia coli pyruvate dehydrogenase complex E1 subunit interact with the E2 subunit and are required for activity of the complex but not for reductive acetylation of the E2 subunit. | Biochemistry 20041109 |
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| Intermolecular interactions in the AhpC/AhpD antioxidant defense system of Mycobacterium tuberculosis. | Archives of biochemistry and biophysics 20040701 |
| Dihydrolipoamide dehydrogenase from porcine heart catalyzes NADH-dependent scavenging of nitric oxide. | FEBS letters 20040618 |
| IAR4, a gene required for auxin conjugate sensitivity in Arabidopsis, encodes a pyruvate dehydrogenase E1alpha homolog. | Plant physiology 20040601 |
| Glutamine synthesis in the developing porcine placenta. | Biology of reproduction 20040501 |
| A proteomic investigation of drug-induced steatosis in rat liver. | Chemical research in toxicology 20040501 |
| Photosensitized NADH formation system with multilayer TiO2 film. | Chemical communications (Cambridge, England) 20040407 |
| Ligand-induced conformational changes and a reaction intermediate in branched-chain 2-oxo acid dehydrogenase (E1) from Thermus thermophilus HB8, as revealed by X-ray crystallography. | Journal of molecular biology 20040402 |
| Diversity of L-leucine catabolism in various microorganisms involved in dairy fermentations, and identification of the rate-controlling step in the formation of the potent flavour component 3-methylbutanal. | Applied microbiology and biotechnology 20040401 |
| Identification of 36 kDa phosphoprotein in fibrous sheath of hamster spermatozoa. | Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20040401 |
| Leucine toxicity in a neuronal cell model with inhibited branched chain amino acid catabolism. | Brain research. Molecular brain research 20040330 |
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| [Effects of bkdAB interruption on avermectin biosynthesis]. | Sheng wu gong cheng xue bao = Chinese journal of biotechnology 20040301 |
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| Lipoic acid-dependent oxidative catabolism of alpha-keto acids in mitochondria provides evidence for branched-chain amino acid catabolism in Arabidopsis. | Plant physiology 20040201 |
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| Flavoprotein disulfide reductases: advances in chemistry and function. | Progress in nucleic acid research and molecular biology 20040101 |
| Protein requirements for endurance athletes. | Nutrition (Burbank, Los Angeles County, Calif.) 20040101 |
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| NarE: a novel ADP-ribosyltransferase from Neisseria meningitidis. | Molecular microbiology 20031101 |
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| Epitope mapping on E1alpha subunit of pyruvate dehydrogenase complex with autoantibodies of patients with primary biliary cirrhosis. | Liver international : official journal of the International Association for the Study of the Liver 20031001 |
| Towards a phosphoproteome map of Corynebacterium glutamicum. | Proteomics 20030801 |
| Phosphorylation of formate dehydrogenase in potato tuber mitochondria. | The Journal of biological chemistry 20030711 |
| Impairment of glucose metabolism and energy transfer in the rat heart. | Molecular and cellular biochemistry 20030701 |
| Reaction mechanism of the heterotetrameric (alpha2beta2) E1 component of 2-oxo acid dehydrogenase multienzyme complexes. | Biochemistry 20030617 |
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| Aerobic growth deficient Haemophilus influenzae mutants are non-virulent: implications on metabolism. | International journal of medical microbiology : IJMM 20030601 |
| Prevention of oxidant-induced cell death by lysosomotropic iron chelators. | Free radical biology & medicine 20030515 |
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| Antisense inhibition of mitochondrial pyruvate dehydrogenase E1alpha subunit in anther tapetum causes male sterility. | The Plant journal : for cell and molecular biology 20030401 |
| 2-Oxo acid dehydrogenase complexes of multicellular organisms. | European journal of biochemistry 20030301 |
| 2-Oxo acid dehydrogenase complexes in redox regulation. | European journal of biochemistry 20030301 |
| Identification of 36-kDa flagellar phosphoproteins associated with hamster sperm motility. | Journal of biochemistry 20030301 |
| Catalysis of diaphorase reactions by Mycobacterium tuberculosis lipoamide dehydrogenase occurs at the EH4 level. | Biochemistry 20030225 |
| Selenite sensitizes mitochondrial permeability transition pore opening in vitro and in vivo: a possible mechanism for chemo-protection. | The Biochemical journal 20030215 |
| A new case of pyruvate dehydrogenase deficiency due to a novel mutation in the PDX1 gene. | Annals of neurology 20030201 |
| Encapsulation of an 86-kDa assembly intermediate inside the cavities of GroEL and its single-ring variant SR1 by GroES. | The Journal of biological chemistry 20030124 |
| [Arsenite-induced lipid peroxidation in Saccharomyces cerevisiae]. | Mikrobiologiia 20030101 |
| Regeneration of the antioxidant ubiquinol by lipoamide dehydrogenase, thioredoxin reductase and glutathione reductase. | BioFactors (Oxford, England) 20030101 |
| Biochemical characterization of two mutants of human pyruvate dehydrogenase, F205L and T231A of the E1alpha subunit. | Journal of inherited metabolic disease 20030101 |
| Antioxidant activities of novel alpha-lipoic acid derivatives: N-(6, 8-dimercaptooctanoyl)-2-aminoethanesulfonate- and N-(6, 8-dimercaptooctanoyl)-L-aspartate-zinc complex. | Research communications in molecular pathology and pharmacology 20030101 |
| Histidine 407, a phantom residue in the E1 subunit of the Escherichia coli pyruvate dehydrogenase complex, activates reductive acetylation of lipoamide on the E2 subunit. An explanation for conservation of active sites between the E1 subunit and transketolase. | Biochemistry 20021231 |
| The lipoamide dehydrogenase from Mycobacterium tuberculosis permits the direct observation of flavin intermediates in catalysis. | Biochemistry 20021210 |
| Clofibric acid stimulates branched-chain amino acid catabolism by three mechanisms. | Archives of biochemistry and biophysics 20021115 |
| Elongation factor Tu and E1 beta subunit of pyruvate dehydrogenase complex act as fibronectin binding proteins in Mycoplasma pneumoniae. | Molecular microbiology 20021101 |
| Folding kinetics of the lipoic acid-bearing domain of human mitochondrial branched chain alpha-ketoacid dehydrogenase complex. | FEBS letters 20021023 |
| Tissue-specific effects of chronic dietary leucine and norleucine supplementation on protein synthesis in rats. | American journal of physiology. Endocrinology and metabolism 20021001 |
| Insulin increases branched-chain alpha-ketoacid dehydrogenase kinase expression in Clone 9 rat cells. | American journal of physiology. Endocrinology and metabolism 20021001 |
| Inactivation of the 2-oxo acid dehydrogenase complexes upon generation of intrinsic radical species. | European journal of biochemistry 20021001 |
| Diagnosis and molecular analysis of three male patients with thiamine-responsive pyruvate dehydrogenase complex deficiency. | Journal of the neurological sciences 20020915 |
| Gene therapy for pyruvate dehydrogenase E1alpha deficiency using recombinant adeno-associated virus 2 (rAAV2) vectors. | Molecular therapy : the journal of the American Society of Gene Therapy 20020901 |
| Glutaredoxins catalyze the reduction of glutathione by dihydrolipoamide with high efficiency. | Biochemical and biophysical research communications 20020802 |
| A novel Y243S mutation in the pyruvate dehydrogenase El alpha gene subunit: correlation with thiamine pyrophosphate interaction. | Journal of inherited metabolic disease 20020801 |
| Detection of pyruvate dehydrogenase E1 alpha-subunit deficiencies in females by immunohistochemical demonstration of mosaicism in cultured fibroblasts. | The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20020701 |
| Interchangeable enzyme modules. Functional replacement of the essential linker of the biotinylated subunit of acetyl-CoA carboxylase with a linker from the lipoylated subunit of pyruvate dehydrogenase. | The Journal of biological chemistry 20020621 |
| Primary biliary cirrhosis: seeking the silent partner of autoimmunity. | Gut 20020601 |
| Diagnosis and treatment of maple syrup disease: a study of 36 patients. | Pediatrics 20020601 |
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| Two-photon fluorescence spectroscopy and microscopy of NAD(P)H and flavoprotein. | Biophysical journal 20020501 |
| The E1beta and E2 subunits of the Bacillus subtilis pyruvate dehydrogenase complex are involved in regulation of sporulation. | Journal of bacteriology 20020501 |
| Maple syrup urine disease: mutation analysis in Turkish patients. | Journal of inherited metabolic disease 20020501 |
| Recurrent intragenomic recombination leading to sequence homogenization during the evolution of the lipoyl-binding domain. | FEMS microbiology letters 20020409 |
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| Cerebral white matter involvement in children with mitochondrial encephalopathies. | Neuropediatrics 20020401 |
| Zinc is a potent inhibitor of thiol oxidoreductase activity and stimulates reactive oxygen species production by lipoamide dehydrogenase. | The Journal of biological chemistry 20020322 |
| Glucose-stimulated insulin secretion does not require activation of pyruvate dehydrogenase: impact of adenovirus-mediated overexpression of PDH kinase and PDH phosphate phosphatase in pancreatic islets. | Biochemical and biophysical research communications 20020308 |
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| Glycogen phosphorylase and pyruvate dehydrogenase transformation in white muscle of trout during high-intensity exercise. | American journal of physiology. Regulatory, integrative and comparative physiology 20020301 |
| Activation of the promoters of Arabidopsis genes for the branched-chain alpha-keto acid dehydrogenase complex in transgenic tobacco BY-2 cells under sugar starvation. | Plant & cell physiology 20020301 |
| Clinical significance of positive immunoblotting but negative immunofluorescence for antimitochondrial antibodies in patients with liver diseases other than primary biliary cirrhosis. | Autoimmunity 20020301 |
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| Characterization of a missense mutation at histidine-44 in a pyruvate dehydrogenase-deficient patient. | Biochimica et biophysica acta 20020102 |
| Evidence of common ancestry for the maple syrup urine disease (MSUD) Y438N allele in non-Mennonite MSUD patients. | Molecular genetics and metabolism 20020101 |
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| The complex fate of alpha-ketoacids. | Annual review of plant biology 20020101 |
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| 3D structure and significance of the GPhiXXG helix packing motif in tetramers of the E1beta subunit of pyruvate dehydrogenase from the archeon Pyrobaculum aerophilum. | Biochemistry 20011204 |
| Dietary L-carnitine suppresses mitochondrial branched-chain keto acid dehydrogenase activity and enhances protein accretion and carcass characteristics of swine. | Journal of animal science 20011201 |
| Gender-specific occurrence of West syndrome in patients with pyruvate dehydrogenase complex deficiency. | Neuropediatrics 20011201 |
| Primary biliary cirrhosis: lessons learned from an organ-specific disease. | Clinical and experimental medicine 20011201 |
| Theoretical study of the conformation of the lipoamide arm in a mutant H protein. | Proteins 20011115 |
| Uteroplacental insufficiency alters liver and skeletal muscle branched-chain amino acid metabolism in intrauterine growth-restricted fetal rats. | Pediatric research 20011101 |
| Differential effects of two mutations at arginine-234 in the alpha subunit of human pyruvate dehydrogenase. | Archives of biochemistry and biophysics 20011101 |
| Purification and characterization of an enzyme from Mycobacterium sp. Pyr-1, with nitroreductase activity and an N-terminal sequence similar to lipoamide dehydrogenase. | Archives of microbiology 20011101 |
| Inactivation of the murine pyruvate dehydrogenase (Pdha1) gene and its effect on early embryonic development. | Molecular genetics and metabolism 20011101 |
| The effect of high-intensity exhaustive exercise studied in isolated mitochondria from human skeletal muscle. | Pflugers Archiv : European journal of physiology 20011101 |
| Natural osmolyte trimethylamine N-oxide corrects assembly defects of mutant branched-chain alpha-ketoacid decarboxylase in maple syrup urine disease. | The Journal of biological chemistry 20011026 |
| A trail of research from lipoic acid to alpha-keto acid dehydrogenase complexes. | The Journal of biological chemistry 20011019 |
| Maple syrup urine disease: identification and carrier-frequency determination of a novel founder mutation in the Ashkenazi Jewish population. | American journal of human genetics 20011001 |
| Characterization of two cDNAs encoding mitochondrial lipoamide dehydrogenase from Arabidopsis. | Plant physiology 20011001 |
| Alpha and beta subunits of pyruvate dehydrogenase E1 from the microsporidian Nosema locustae: mitochondrion-derived carbon metabolism in microsporidia. | Molecular and biochemical parasitology 20011001 |
| A case of PDH-E1 alpha mosaicism in a male patient with severe metabolic lactic acidosis. | Journal of inherited metabolic disease 20011001 |
| Modification by exercise training of activity and enzyme expression of hepatic branched-chain alpha-ketoacid dehydrogenase complex in streptozotocin-induced diabetic rats. | Journal of nutritional science and vitaminology 20011001 |
| Biochemical basis of type IB (E1beta ) mutations in maple syrup urine disease. A prevalent allele in patients from the Druze kindred in Israel. | The Journal of biological chemistry 20010928 |
| Mycobacterium tuberculosis lipoamide dehydrogenase is encoded by Rv0462 and not by the lpdA or lpdB genes. | Biochemistry 20010925 |
| Fluorescence correlation spectroscopy of flavins and flavoenzymes: photochemical and photophysical aspects. | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20010914 |
| Regulation of branched-chain amino acid catabolism: nutritional and hormonal regulation of activity and expression of the branched-chain alpha-keto acid dehydrogenase kinase. | Current opinion in clinical nutrition and metabolic care 20010901 |
| Effects of bezafibrate on beta-cell function of rat pancreatic islets. | European journal of pharmacology 20010831 |
| Lipoamide dehydrogenase from Corynebacterium glutamicum: molecular and physiological analysis of the lpd gene and characterization of the enzyme. | Microbiology (Reading, England) 20010801 |
| Tissue-specific and developmental-specific expression of an Arabidopsis thaliana gene encoding the lipoamide dehydrogenase component of the plastid pyruvate dehydrogenase complex. | Plant molecular biology 20010801 |
| Leucine and its keto acid enhance the coordinated expression of genes for branched-chain amino acid catabolism in Arabidopsis under sugar starvation. | FEBS letters 20010615 |
| Electrocatalytic reduction of lipoic acid and electroenzymatic reduction of NAD(P)(+) for integrated dehydrogenase biosensors. | Biosensors & bioelectronics 20010601 |
| Autoantibodies of sera from patients with primary biliary cirrhosis recognize the alpha subunit of the decarboxylase component of human branched-chain 2-oxo acid dehydrogenase complex. | Journal of hepatology 20010601 |
| Carrier detection and rapid newborn diagnostic test for the common Y393N maple syrup urine disease allele by PCR-RFLP: culturally permissible testing in the Mennonite community. | Journal of inherited metabolic disease 20010601 |
| Human populations show reduced DNA sequence variation at the factor IX locus. | Current biology : CB 20010515 |
| Acidification and glucocorticoids independently regulate branched-chain alpha-ketoacid dehydrogenase subunit genes. | American journal of physiology. Cell physiology 20010501 |
| Protection by thiols of the mitochondrial complexes from 4-hydroxy-2-nonenal. | Free radical biology & medicine 20010501 |
| [Mitochondrial DNA T to G mutation 8993 in Leigh encephalopathy and organic aciduria]. | No to hattatsu = Brain and development 20010501 |
| Reduction of ubiquinone by lipoamide dehydrogenase. An antioxidant regenerating pathway. | European journal of biochemistry 20010301 |
| Inhibitory effect of alpha-lipoic acid and its positively charged amide analogue on nitric oxide production in RAW 264.7 macrophages. | Biochemical pharmacology 20010301 |
| Congenital lactic acidosis: evaluation of the properties of the a199t natural variant of human pyruvate dehydrogenase e1alpha by in vitro mutation. | Molecular genetics and metabolism 20010301 |
| Regulation of the activity of branched-chain 2-oxo acid dehydrogenase (BCODH) complex by binding BCODH kinase. | FEBS letters 20010223 |
| 2- and 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: synthesis and correlation between redox cycling activities and in vitro cytotoxicity. | Journal of medicinal chemistry 20010215 |
| Reaction mechanism for mammalian pyruvate dehydrogenase using natural lipoyl domain substrates. | Archives of biochemistry and biophysics 20010215 |
| Roles of active site and novel K+ ion-binding site residues in human mitochondrial branched-chain alpha-ketoacid decarboxylase/dehydrogenase. | The Journal of biological chemistry 20010209 |
| cDNA cloning of the chicken branched-chain alpha-keto acid dehydrogenase complex. Chicken-specific residues of the acyltransferase affect the overall activity and the interaction with the dehydrogenase. | European journal of biochemistry 20010201 |
| Multiple display of peptides and proteins on a macromolecular scaffold derived from a multienzyme complex. | Journal of molecular biology 20010112 |
| Gene preference in maple syrup urine disease. | American journal of human genetics 20010101 |
| Effect of starvation on branched-chain alpha-keto acid dehydrogenase activity in rat heart and skeletal muscle. | Physiological research 20010101 |
| Channeling of substrates and intermediates in enzyme-catalyzed reactions. | Annual review of biochemistry 20010101 |
| [Disorders of pyruvate metabolism and TCA cycle]. | Ryoikibetsu shokogun shirizu 20010101 |
| Alpha-lipoic acid and alpha-lipoamide prevent oxidant-induced lysosomal rupture and apoptosis. | Redox report : communications in free radical research 20010101 |
| Induction of expression of branched-chain aminotransferase and alpha-keto acid dehydrogenase in rat tissues during lactation. | Advances in experimental medicine and biology 20010101 |
| Lipid peroxidation of erythrocyte membrane induced by lipoamide dehydrogenase in the presence of ADP-Fe3+. | Pharmacology & toxicology 19921001 |
| Thioredoxin fragment 31-36 is reduced by dihydrolipoamide and reduces oxidized protein. | Biochemical and biophysical research communications 19880115 |
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