200,000+ products from a single source!
sales@angenechem.com
Home > Other Building Blocks > 307297-39-8
307297-39-8 | Glycine, L-alanyl-L-α-glutamyl-L-α-aspartyl-
CAS No: 307297-39-8 Catalog No: AG003123 MDL No:
Product Description
Catalog Number:
AG003123
Chemical Name:
Glycine, L-alanyl-L-α-glutamyl-L-α-aspartyl-
CAS Number:
307297-39-8
Molecular Formula:
C14H22N4O9
Molecular Weight:
390.3459
IUPAC Name:
(4S)-4-[[(2S)-2-aminopropanoyl]amino]-5-[[(2S)-3-carboxy-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
InChI:
InChI=1S/C14H22N4O9/c1-6(15)12(25)17-7(2-3-9(19)20)14(27)18-8(4-10(21)22)13(26)16-5-11(23)24/h6-8H,2-5,15H2,1H3,(H,16,26)(H,17,25)(H,18,27)(H,19,20)(H,21,22)(H,23,24)/t6-,7-,8-/m0/s1
InChI Key:
HGHOBRRUMWJWCU-FXQIFTODSA-N
SMILES:
OC(=O)CC[C@@H](C(=O)N[C@H](C(=O)NCC(=O)O)CC(=O)O)NC(=O)[C@@H](N)C
UNII:
O65P17785G
Properties
Complexity:
607
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
3
Defined Bond Stereocenter Count:
0
Exact Mass:
390.139g/mol
Formal Charge:
0
Heavy Atom Count:
27
Hydrogen Bond Acceptor Count:
10
Hydrogen Bond Donor Count:
7
Isotope Atom Count:
0
Molecular Weight:
390.349g/mol
Monoisotopic Mass:
390.139g/mol
Rotatable Bond Count:
12
Topological Polar Surface Area:
225A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-5.5
Literature
| Title | Journal |
|---|---|
| Molecular cellular mechanisms of peptide regulation of melatonin synthesis in pinealocyte culture. | Bulletin of experimental biology and medicine 20120601 |
| [Morphofunctional and molecular bases of pineal gland aging]. | Fiziologiia cheloveka 20120101 |
| Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA. | Biochemistry. Biokhimiia 20111101 |
| Biological stability evaluation of the α2β1 receptor imaging agents: diamsar and DOTA conjugated DGEA peptide. | Bioconjugate chemistry 20110216 |
| Effects of peptides Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly on hormonal activity and structure of the thyroid gland in hypophysectomized young chickens and old hens. | Bulletin of experimental biology and medicine 20110201 |
| [Characteristics of the pineal gland and thymus relationship in aging]. | Advances in gerontology = Uspekhi gerontologii 20110101 |
| [Effects of Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly peptides on hormonal activity and thyroid morphology in hypophysectomized mature and old birds]. | Advances in gerontology = Uspekhi gerontologii 20110101 |
| [Effects of hypophyseal Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly synthetic peptides on immunity, hemostasis, morphology and functions of the thyroid gland in neonatally hypophysectomized chicken and one-year-old birds]. | Patologicheskaia fiziologiia i eksperimental'naia terapiia 20100101 |
| [The use of peptide bioregulators for cancer prevention: results of 35 years of research experience and perspectives]. | Voprosy onkologii 20090101 |
| [Effect of preparations melatonin and epitalon on the age-related dynamics of thyrotrophic activity of the hypophysis and thyroid gland function in different light regimes]. | Advances in gerontology = Uspekhi gerontologii 20090101 |
| Melting of DNA double strand after binding to geroprotective tetrapeptide. | Bulletin of experimental biology and medicine 20081101 |
| Geroprotective effect of ala-glu-asp-gly peptide in male rats exposed to different illumination regimens. | Bulletin of experimental biology and medicine 20080401 |
| Comparative analysis of the expression of c-Fos and interleukin-2 proteins in hypothalamus cells during various treatments. | Neuroscience and behavioral physiology 20080301 |
| Effect of tetrapeptides Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly on the structure and function of the thyroid gland in neonatally hypophysectomized chickens. | Bulletin of experimental biology and medicine 20080101 |
| [Effects of epithalon and cortagene on immunity and hemostasis in neonatally hypophysectomized chicken and old birds]. | Advances in gerontology = Uspekhi gerontologii 20080101 |
| [The influences of geroprotectors on age-related changes of antioxidant system in rats liver under different light condition]. | Advances in gerontology = Uspekhi gerontologii 20080101 |
| [The influence of melatonin and epithalon on blood leukocyte count and leukocyte alkaline phosphatase in rats under different lighting conditions during ontogenesis]. | Advances in gerontology = Uspekhi gerontologii 20080101 |
| Effect of Ala-Glu-Asp-Gly peptide on life span and development of spontaneous tumors in female rats exposed to different illumination regimes. | Bulletin of experimental biology and medicine 20071201 |
| Effects of intranasal administration of epitalon on neuron activity in the rat neocortex. | Neuroscience and behavioral physiology 20071101 |
| Effects of bioactive tetrapeptides on free-radical processes. | Bulletin of experimental biology and medicine 20070601 |
| [Parallel analysis of c-Fos protein and interleukin-2 expression in hypothalamic cells under different influence]. | Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20070201 |
| Antioxidant properties of geroprotective peptides of the pineal gland. | Archives of gerontology and geriatrics 20070101 |
| [Age-related changes of exercise capacity and some biochemical indices of rat muscles under influence of different light conditions and pineal preparations]. | Advances in gerontology = Uspekhi gerontologii 20070101 |
| [Normalizing effect of the pineal gland peptides on the daily melatonin rhythm in old monkeys and elderly people]. | Advances in gerontology = Uspekhi gerontologii 20070101 |
| [Effect of pineal gland peptides on morphofunctional structure of the pancreas in ageing]. | Advances in gerontology = Uspekhi gerontologii 20070101 |
| [Circannual rhythms of bone marrow cell composition in animals during aging: the role of pineal factors]. | Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20070101 |
| [Intranasal epitalon infusion modulates neuronal activity in the rat neocortex]. | Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20060801 |
| Anti-aging peptide bioregulators induce reactivation of chromatin. | Georgian medical news 20060401 |
| Interleukin-2 concentration in hypothalamic structures of rats receiving peptides during mild stress. | Bulletin of experimental biology and medicine 20060401 |
| Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice. | In vivo (Athens, Greece) 20060101 |
| [Effects of melatonin and epitalone on antioxidant system of rats depends on light conditions]. | Patologicheskaia fiziologiia i eksperimental'naia terapiia 20060101 |
| [Influence of light regimens, melatonin, and epitalon on amylase activity in the pancreas and small intestine in rats of different age]. | Advances in gerontology = Uspekhi gerontologii 20060101 |
| [Effect of age, different light conditions, melatonin, and epitalon on lysosomal proteinase activity in the liver and kidneys of rats]. | Advances in gerontology = Uspekhi gerontologii 20060101 |
| [Comparative study of the effects of melatonin and epitalon on the protracted memory under the shuttle labyrinth test conditions in rats in the course of aging]. | Eksperimental'naia i klinicheskaia farmakologiia 20060101 |
| Fluorescent microscopic study of epithalon binding in maternal and fetal rabbit tissues in health and under conditions of placental insufficiency. | Bulletin of experimental biology and medicine 20050501 |
| Pineal peptides restore the age-related disturbances in hormonal functions of the pineal gland and the pancreas. | Experimental gerontology 20050101 |
| [Effect of epitalon and melatonin on life span and spontaneous carcinogenesis in senescence accelerated mice (SAM)]. | Voprosy onkologii 20050101 |
| Effect of melatonin and tetrapeptide on gene expression in mouse brain. | Bulletin of experimental biology and medicine 20041101 |
| Stressors and antistressors: how do they influence life span in HER-2/neu transgenic mice? | Experimental gerontology 20041001 |
| Peptide correction of age-related hormonal dysfunction of the pancreas in monkeys. | Bulletin of experimental biology and medicine 20040701 |
| Expression of argyrophilic proteins in the nucleolar organizer regions of human thymocytes and thymic epitheliocytes under conditions of coculturing with vilon and epithalon peptides. | Bulletin of experimental biology and medicine 20040601 |
| Peptide promotes overcoming of the division limit in human somatic cell. | Bulletin of experimental biology and medicine 20040501 |
| Effects of bioactive factors of the pineal gland on thymus function and cell composition of the bone marrow and spleen in mice of different age. | Bulletin of experimental biology and medicine 20040501 |
| Elucidation of the effect of brain cortex tetrapeptide Cortagen on gene expression in mouse heart by microarray. | Neuro endocrinology letters 20040101 |
| [Effect of epitalon on the immunity and hemostasis in hypophysectomized chicken and old hens]. | Advances in gerontology = Uspekhi gerontologii 20040101 |
| [The influence of substances revealing geroprotective of spontaneous carcinogenesis in mice]. | Advances in gerontology = Uspekhi gerontologii 20040101 |
| Epitalon and colon carcinogenesis in rats: proliferative activity and apoptosis in colon tumors and mucosa. | International journal of molecular medicine 20031001 |
| Peptide Epitalon activates chromatin at the old age. | Neuro endocrinology letters 20031001 |
| Effect of regulatory peptides on gene transcription. | Bulletin of experimental biology and medicine 20030901 |
| The role of pineal gland in breast cancer development. | Critical reviews in oncology/hematology 20030601 |
| Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. | Bulletin of experimental biology and medicine 20030601 |
| Effects of peptides on proliferative activity of retinal and pigmented epithelial cells. | Bulletin of experimental biology and medicine 20030601 |
| Retinoprotective effect of Epithalon in campbell rats of various ages. | Bulletin of experimental biology and medicine 20030501 |
| Effect of a synthetic pineal tetrapeptide (Ala-Glu-Asp-GLy) on melatonin secretion by the pineal gland of young and old rats. | Journal of endocrinological investigation 20030301 |
| [The study of the role of the water medium in the mechanism of action of peptides in low and ultra low doses]. | Radiatsionnaia biologiia, radioecologiia 20030101 |
| [Effect of new peptide bioregulators livagen and epitalon on enkephalin-degrading enzymes in human serum]. | Izvestiia Akademii nauk. Seriia biologicheskaia 20030101 |
| Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. | Biogerontology 20030101 |
| [Regulating effect of pineal gland peptides on development of T-lymphocytes in CBA aging mice: role of microenvironment of immune system organs and neuroendocrine factors]. | Advances in gerontology = Uspekhi gerontologii 20030101 |
| [Peptide correction of age-related pineal disturbances in monkeys]. | Advances in gerontology = Uspekhi gerontologii 20030101 |
| Effect of vilon and epithalon on activity of enzymes in epithelial and subepithelial layers in small intestine of old rats. | Bulletin of experimental biology and medicine 20021201 |
| Inhibitory effect of peptide Epitalon on colon carcinogenesis induced by 1,2-dimethylhydrazine in rats. | Cancer letters 20020908 |
| Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. | International journal of cancer 20020901 |
| Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa. | Neuro endocrinology letters 20020801 |
| Epithalon decelerates aging and suppresses development of breast adenocarcinomas in transgenic her-2/neu mice. | Bulletin of experimental biology and medicine 20020801 |
| In vitro effect of short peptides on expression of interleukin-2 gene in splenocytes. | Bulletin of experimental biology and medicine 20020601 |
| Effect of Vilon and Epithalon on glucose and glycine absorption in various regions of small intestine in aged rats. | Bulletin of experimental biology and medicine 20020501 |
| Effects of short peptides on thymocyte blast transformation and signal transduction along the sphingomyelin pathway. | Bulletin of experimental biology and medicine 20020501 |
| Effect of epithalon on the incidence of chromosome aberrations in senescence-accelerated mice. | Bulletin of experimental biology and medicine 20020301 |
| Effects of epithalon on activities gastrointestinal enzymes in young and old rats. | Bulletin of experimental biology and medicine 20020301 |
| Studies of the effects of Vilon and Epithalon on gene expression in mouse heart using DNA-microarray technology. | Bulletin of experimental biology and medicine 20020301 |
| Epithalon inhibits tumor growth and expression of HER-2/neu oncogene in breast tumors in transgenic mice characterized by accelerated aging. | Bulletin of experimental biology and medicine 20020201 |
| [Aging of the pineal gland]. | Advances in gerontology = Uspekhi gerontologii 20020101 |
| [Effect of Epitalon and Vilon treatment on mammary carcinogenesis in transgenic erbB-2/NEU mice]. | Voprosy onkologii 20020101 |
| Effect of epithalon on age-specific changes in the retina in rats with hereditary pigmentary dystrophy. | Bulletin of experimental biology and medicine 20020101 |
| Peptides and Ageing. | Neuro endocrinology letters 20020101 |
| Effects of pineal-gland peptides on the electric activity of pinealocytes in rats. | Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 20020101 |
| Effect of epitalon on interleukin-1beta signal transduction and the reaction of thymocyte blast transformation under stress. | Neuro endocrinology letters 20020101 |
| Epitalon influences pineal secretion in stress-exposed rats in the daytime. | Neuro endocrinology letters 20020101 |
| Modulating effects of epithalamin and epithalon on the functional morphology of the spleen in old pinealectomized rats. | Bulletin of experimental biology and medicine 20011101 |
| Synthetic tetrapeptide epitalon restores disturbed neuroendocrine regulation in senescent monkeys. | Neuro endocrinology letters 20010801 |
| Effects of peptides on generation of reactive oxygen species in subcellular fractions of Drosophila melanogaster. | Bulletin of experimental biology and medicine 20010701 |
| Regulatory effect of Epithalon on production of melatonin and cortisol in old monkeys. | Bulletin of experimental biology and medicine 20010401 |
| Immunohistochemical and morphometric analysis of effects of vilon and epithalon on functional morphology of radiosensitive organs. | Bulletin of experimental biology and medicine 20010301 |
| [Effect of pineal peptide on parameters of the biological age and life span in mice]. | Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20010101 |
| Reparative effect of epithalon on pineal gland ultrastructure in gamma-irradiated rats. | Bulletin of experimental biology and medicine 20010101 |
| [Effect of pineal peptides on neuroendocrine system after pinealectomy]. | Arkhiv patologii 20010101 |
| [Effect of epithalone on growth kinetics and functional morphology of M-1 sarcoma]. | Voprosy onkologii 20010101 |
| [Effect of vilon and epithalone on induction and growth of induced bladder neoplasms in rats]. | Voprosy onkologii 20010101 |
| [Rhythm of protein synthesis in cultures of hepatocytes from rats of different ages. Norm and effect of the peptide livagen]. | Izvestiia Akademii nauk. Seriia biologicheskaia 20010101 |
Related Products
Featured Products
© 2019 Angene International Limited. All rights Reserved.