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30652-11-0 | 4(1H)-Pyridinone, 3-hydroxy-1,2-dimethyl-
CAS No: 30652-11-0 Catalog No: AG0030RL MDL No:MFCD00134497
Product Description
Catalog Number:
AG0030RL
Chemical Name:
4(1H)-Pyridinone, 3-hydroxy-1,2-dimethyl-
CAS Number:
30652-11-0
Molecular Formula:
C7H9NO2
Molecular Weight:
139.1519
MDL Number:
MFCD00134497
IUPAC Name:
3-hydroxy-1,2-dimethylpyridin-4-one
InChI:
InChI=1S/C7H9NO2/c1-5-7(10)6(9)3-4-8(5)2/h3-4,10H,1-2H3
InChI Key:
TZXKOCQBRNJULO-UHFFFAOYSA-N
SMILES:
Cn1ccc(=O)c(c1C)O
UNII:
2BTY8KH53L
NSC Number:
758880
Properties
Complexity:
228
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
139.063g/mol
Formal Charge:
0
Heavy Atom Count:
10
Hydrogen Bond Acceptor Count:
3
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
139.154g/mol
Monoisotopic Mass:
139.063g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
40.5A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
0.5
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| [Epidemiological and economic aspects of chelating therapy in the therapeutic center of thalassemia in Morocco]. | Revue medicale de Bruxelles 20100101 |
| Current and emerging treatment options in the management of Friedreich ataxia. | Neuropsychiatric disease and treatment 20100101 |
| Iron overload in patients undergoing hematopoietic stem cell transplantation. | Advances in hematology 20100101 |
| Hepcidin induces HIV-1 transcription inhibited by ferroportin. | Retrovirology 20100101 |
| Cardiac events and cardiac T2* in Egyptian children and young adults with beta-thalassemia major taking deferoxamine. | Hematology/oncology and stem cell therapy 20100101 |
| The pro-BNP Serum Level and Echocardiographic Tissue Doppler Abnormalities in Patients with Beta Thalassemia Major. | Clinical Medicine Insights. Cardiology 20100101 |
| Update on iron chelators in thalassemia. | Hematology. American Society of Hematology. Education Program 20100101 |
| Effect of Triphaladi Avaleha as an adjuvant therapy in the management of Thalassemia. | Ayu 20100101 |
| Contractile and morphological properties of hamster retractor muscle following 16 h of cold preservation. | Cryobiology 20091201 |
| Daily labile plasma iron as an indicator of chelator activity in Thalassaemia major patients. | British journal of haematology 20091201 |
| The effects of deferiprone and deferasirox on the structure and function of beta-thalassemia hemoglobin. | Journal of biomolecular structure & dynamics 20091201 |
| Improved survival in thalassemia major patients on switching from desferrioxamine to combined chelation therapy with desferrioxamine and deferiprone. | Haematologica 20091201 |
| Early cardiac iron overload in children with transfusion-dependent anemias. | Haematologica 20091201 |
| The selective quantification of iron by hexadentate fluorescent probes. | Bioorganic & medicinal chemistry 20091201 |
| Early detection of iron overload in the heart: a key role for MRI! | The international journal of cardiovascular imaging 20091201 |
| Iron toxicity: optimizing chelation therapy across transfusion-dependent anaemias. Introduction. | Blood reviews 20091201 |
| Optimizing iron chelation strategies in beta-thalassaemia major. | Blood reviews 20091201 |
| Synthetic and natural iron chelators: therapeutic potential and clinical use. | Future medicinal chemistry 20091201 |
| Iron chelation therapy in the management of thalassemia: the Asian perspectives. | International journal of hematology 20091101 |
| The role of iron and iron chelators in zygomycosis. | Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20091001 |
| Necrotizing stomatitis: a possible periodontal manifestation of deferiprone-induced agranulocytosis. | Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20091001 |
| Skin diseases in patients with beta-thalassemia major. | International journal of dermatology 20091001 |
| Efficacy of curcuminoids in alleviation of iron overload and lipid peroxidation in thalassemic mice. | Medicinal chemistry (Shariqah (United Arab Emirates)) 20090901 |
| Dexrazoxane-afforded protection against chronic anthracycline cardiotoxicity in vivo: effective rescue of cardiomyocytes from apoptotic cell death. | British journal of cancer 20090901 |
| Efficacy of combined desferrioxamine and deferiprone versus single desferrioxamine therapy in patients with major thalassemia. | Archives of Iranian medicine 20090901 |
| A bis(3-hydroxy-4-pyridinone)-EDTA derivative as a strong chelator for M3+ hard metal ions: complexation ability and selectivity. | Dalton transactions (Cambridge, England : 2003) 20090821 |
| Comparison of the effects of deferasirox, deferiprone, and deferoxamine on the growth and virulence of Vibrio vulnificus. | Transfusion 20090801 |
| Radiation nephropathy is not mitigated by antagonists of oxidative stress. | Radiation research 20090801 |
| Posterior subcapsular opacity in two patients with thalassaemia major following deferiprone consumption. | Clinical & experimental optometry 20090701 |
| Atrial and ventricular function in thalassemic patients with supra-ventricular arrhythmias. | Heart international 20090630 |
| Efficacy and safety of deferasirox, an oral iron chelator, in heavily iron-overloaded patients with beta-thalassaemia: the ESCALATOR study. | European journal of haematology 20090601 |
| Reduction in labile plasma iron during treatment with deferasirox, a once-daily oral iron chelator, in heavily iron-overloaded patients with beta-thalassaemia. | European journal of haematology 20090601 |
| Prospects for introducing deferiprone as potent pharmaceutical antioxidant. | Frontiers in bioscience (Elite edition) 20090601 |
| Oral iron chelation therapy with deferiprone in patients with Thalassemia Major. | JPMA. The Journal of the Pakistan Medical Association 20090601 |
| Pharmaco/ferrokinetic-related pro-oxidant activity of deferiprone in beta-thalassemia. | Free radical research 20090501 |
| Bioequivalence study of a film-coated tablet of deferiprone in healthy Thai volunteers. | International journal of clinical pharmacology and therapeutics 20090501 |
| Deferiprone-induced arthropathy in thalassemia: MRI findings in a case. | The Indian journal of radiology & imaging 20090501 |
| Biospeciation of various antidiabetic V(IV)O compounds in serum. | Dalton transactions (Cambridge, England : 2003) 20090407 |
| Long-term sequential deferiprone-deferoxamine versus deferiprone alone for thalassaemia major patients: a randomized clinical trial. | British journal of haematology 20090401 |
| Effect of iron-chelator deferiprone on the in vitro growth of staphylococci. | Journal of Korean medical science 20090401 |
| 2-Acetylpyridine thiosemicarbazones are potent iron chelators and antiproliferative agents: redox activity, iron complexation and characterization of their antitumor activity. | Journal of medicinal chemistry 20090312 |
| Hepatitis B virus reactivation during combined therapy with deferiprone and desferioxamine in a hepatitis B surface antigen thalassemic carrier. | International journal of hematology 20090301 |
| Cost analysis of iron-related complications in a single institute. | The Korean journal of internal medicine 20090301 |
| Deferiprone glucuronidation by human tissues and recombinant UDP glucuronosyltransferase 1A6: an in vitro investigation of genetic and splice variants. | Drug metabolism and disposition: the biological fate of chemicals 20090201 |
| High doses of deferiprone may be associated with cerebellar syndrome. | BMJ (Clinical research ed.) 20090122 |
| Deferasirox for the treatment of iron overload associated with regular blood transfusions (transfusional haemosiderosis) in patients suffering with chronic anaemia: a systematic review and economic evaluation. | Health technology assessment (Winchester, England) 20090101 |
| Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases. | BMC medical genomics 20090101 |
| Impaired nuclear Nrf2 translocation undermines the oxidative stress response in Friedreich ataxia. | PloS one 20090101 |
| Improving survival with deferiprone treatment in patients with thalassemia major: a prospective multicenter randomised clinical trial under the auspices of the Italian Society for Thalassemia and Hemoglobinopathies. | Blood cells, molecules & diseases 20090101 |
| Pharmacotherapy for Friedreich ataxia. | CNS drugs 20090101 |
| Fatal congestive heart failure with deferiprone. | Gastroenterologie clinique et biologique 20090101 |
| The efficacy of iron chelator regimes in reducing cardiac and hepatic iron in patients with thalassaemia major: a clinical observational study. | Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 20090101 |
| Severe hypochromic microcytic anemia in a patient with congenital atransferrinemia. | Pediatric hematology and oncology 20090101 |
| Oral iron chelators. | Annual review of medicine 20090101 |
| ER stress-inducible factor CHOP affects the expression of hepcidin by modulating C/EBPalpha activity. | PloS one 20090101 |
| Red blood cell transfusion therapy and iron chelation in patients with myelodysplastic syndromes. | Clinical lymphoma & myeloma 20090101 |
| Advances in the prevention and treatment are changing thalassemia from a fatal to a chronic disease. experience from a Cyprus model and its use as a paradigm for future applications. | Hemoglobin 20090101 |
| Update on thalassemia treatment in Taiwan, including bone marrow transplantation, chelation therapy, and cardiomyopathy treatment effects. | Hemoglobin 20090101 |
| Uses and limitations of serum ferritin, magnetic resonance imaging T2 and T2* in the diagnosis of iron overload and in the ferrikinetics of normalization of the iron stores in thalassemia using the International Committee on Chelation deferiprone/deferoxamine combination protocol. | Hemoglobin 20090101 |
| A practical chelation protocol based on stratification of thalassemic patients by serum ferritin and magnetic resonance imaging cardiac T2*. | Hemoglobin 20090101 |
| A new era in iron chelation therapy: the design of optimal, individually adjusted iron chelation therapies for the complete removal of iron overload in thalassemia and other chronically transfused patients. | Hemoglobin 20090101 |
| Treatment with deferiprone for iron overload alleviates bone marrow failure in a Fanconi anemia patient. | Hemoglobin 20090101 |
| Effects of chelators (deferoxamine, deferiprone and deferasirox) on the growth of Klebsiella pneumoniae and Aeromonas hydrophila isolated from transfusion-dependent thalassemia patients. | Hemoglobin 20090101 |
| Risk/benefit assessment, advantages over other drugs and targeting methods in the use of deferiprone as a pharmaceutical antioxidant in iron loading and non iron loading conditions. | Hemoglobin 20090101 |
| Inhibition of HIV-1 gene expression by Ciclopirox and Deferiprone, drugs that prevent hypusination of eukaryotic initiation factor 5A. | Retrovirology 20090101 |
| Update on the use of deferasirox in the management of iron overload. | Therapeutics and clinical risk management 20090101 |
| Deferiprone chelation therapy for thalassemia major. | Acta haematologica 20090101 |
| Prediction of pharmacological and xenobiotic responses to drugs based on time course gene expression profiles. | PloS one 20090101 |
| Prevention of cardiomyopathy in transfusion-dependent homozygous thalassaemia today and the role of cardiac magnetic resonance imaging. | Advances in hematology 20090101 |
| Managing myelodysplastic symptoms in elderly patients. | Clinical interventions in aging 20090101 |
| Overview of iron chelation therapy with desferrioxamine and deferiprone. | Hemoglobin 20090101 |
| Update on survival in thalassemia major. | Hemoglobin 20090101 |
| Yersiniabactin reduces the respiratory oxidative stress response of innate immune cells. | PloS one 20090101 |
| Cardiac function and iron chelation in thalassemia major and intermedia: a review of the underlying pathophysiology and approach to chelation management. | Mediterranean journal of hematology and infectious diseases 20090101 |
| Hematopietic stem cell transplantation in thalassemia and related disorders. | Mediterranean journal of hematology and infectious diseases 20090101 |
| Hematopoietic stem cell transplantation in thalassemia and sickle cell disease. Unicenter experience in a multi-ethnic population. | Mediterranean journal of hematology and infectious diseases 20090101 |
| Infections in thalassemia and hemoglobinopathies: focus on therapy-related complications. | Mediterranean journal of hematology and infectious diseases 20090101 |
| Iron chelation therapy in thalassemia syndromes. | Mediterranean journal of hematology and infectious diseases 20090101 |
| Cell functions impaired by frataxin deficiency are restored by drug-mediated iron relocation. | Blood 20081215 |
| Iron acquisition: a novel perspective on mucormycosis pathogenesis and treatment. | Current opinion in infectious diseases 20081201 |
| Deferiprone-related arthropathy of the knee in a thalassemic patient: report of a case and review of the literature. | Clinical rheumatology 20081101 |
| Update on toxicity and efficacy aspects of treatment with deferasirox and its implication on the morbidity and mortality of transfused iron loaded patients. | Expert opinion on drug safety 20081101 |
| Current status in iron chelation in hemoglobinopathies. | Current molecular medicine 20081101 |
| Hypogonadism, diabetes mellitus, hypothyroidism, hypoparathyroidism: incidence and prevalence related to iron overload and chelation therapy in patients with thalassaemia major followed from 1980 to 2007 in the Ferrara Centre. | Pediatric endocrinology reviews : PER 20081001 |
| Treatment of iron overload in thalassemia. | Pediatric endocrinology reviews : PER 20081001 |
| Ethnopharmacology. | Indian journal of pharmacology 20081001 |
| Agranulocyosis in Beta Thalassemia Major Patients treated with Oral Iron Chelating Agent (Deferiprone). | Oman medical journal 20081001 |
| Diagnosing and treating Diamond Blackfan anaemia: results of an international clinical consensus conference. | British journal of haematology 20080901 |
| Targeting the lysosome: fluorescent iron(III) chelators to selectively monitor endosomal/lysosomal labile iron pools. | Journal of medicinal chemistry 20080814 |
| Iron-dependent regulation of frataxin expression: implications for treatment of Friedreich ataxia. | Human molecular genetics 20080801 |
| Rapid iron loading in a pregnant woman with transfusion-dependent thalassemia after brief cessation of iron chelation therapy. | European journal of haematology 20080801 |
| Adherence to desferrioxamine and deferiprone and the impact of deferiprone co-prescription in thalassaemia major patients. Does the addition of deferiprone improve adherence? | British journal of haematology 20080801 |
| Iron chelation therapy: clinical effectiveness, economic burden and quality of life in patients with iron overload. | Advances in therapy 20080801 |
| Interactions of insulin-mimetic zinc(II) complexes with cell constituents: glutathione and ATP. | Journal of inorganic biochemistry 20080701 |
| Iron chelation in thalassemia: combined or monotherapy? The Egyptian experience. | Annals of hematology 20080701 |
| Protection against hydrogen peroxide-mediated cytotoxicity in Friedreich's ataxia fibroblasts using novel iron chelators of the 2-pyridylcarboxaldehyde isonicotinoyl hydrazone class. | Molecular pharmacology 20080701 |
| Deferiprone does not protect against chronic anthracycline cardiotoxicity in vivo. | The Journal of pharmacology and experimental therapeutics 20080701 |
| Alternative treatment paradigm for thalassemia using iron chelators. | Experimental hematology 20080701 |
| Influence of iron chelation on R1 and R2 calibration curves in gerbil liver and heart. | Magnetic resonance in medicine 20080701 |
| Early impairment of myocardial function in young patients with beta-thalassemia major. | European journal of haematology 20080601 |
| UGT1A6 genotype-related pharmacokinetics of deferiprone (L1) in healthy volunteers. | British journal of clinical pharmacology 20080601 |
| Neuroprotective actions of deferiprone in cultured cortical neurones and SHSY-5Y cells. | Journal of neurochemistry 20080601 |
| Influence of iron chelators on myocardial iron and cardiac function in transfusion-dependent thalassaemia: a systematic review and meta-analysis. | British journal of haematology 20080601 |
| The labile iron pool in human erythroid cells. | British journal of haematology 20080601 |
| Basic 3-hydroxypyridin-4-ones: potential antimalarial agents. | European journal of medicinal chemistry 20080501 |
| Italian Society of Hematology practice guidelines for the management of iron overload in thalassemia major and related disorders. | Haematologica 20080501 |
| Chelation of bismuth by combining desferrioxamine and deferiprone in rats. | Toxicology and industrial health 20080501 |
| The involvement of lysosomes in myocardial aging and disease. | Current cardiology reviews 20080501 |
| Regression of symptoms after selective iron chelation therapy in a case of neurodegeneration with brain iron accumulation. | Movement disorders : official journal of the Movement Disorder Society 20080430 |
| A new lactoferrin- and iron-dependent lysosomal death pathway is induced by benzo[a]pyrene in hepatic epithelial cells. | Toxicology and applied pharmacology 20080415 |
| The fenton activity of iron(III) in the presence of deferiprone. | Journal of pharmaceutical sciences 20080401 |
| What is new in iron overload? | European journal of pediatrics 20080401 |
| Potentiometric, spectrophotometric and calorimetric study on iron(III) and copper(II) complexes with 1,2-dimethyl-3-hydroxy-4-pyridinone. | Journal of inorganic biochemistry 20080401 |
| Oral iron chelators. | Pediatric clinics of North America 20080401 |
| Long-term efficacy of oral deferiprone in management of iron overload in beta thalassemia major. | Hematology (Amsterdam, Netherlands) 20080401 |
| Iron overload in myelodysplastic syndromes (MDS) - diagnosis, management, and response criteria: a proposal of the Austrian MDS platform. | European journal of clinical investigation 20080301 |
| Iron overload disorders: treatment options for patients refractory to or intolerant of phlebotomy. | Pharmacotherapy 20080301 |
| Electrocatalytic oxidation and determination of deferasirox and deferiprone on a nickel oxyhydroxide-modified electrode. | Analytical biochemistry 20080215 |
| Severe Henoch-Schönlein purpura in a thalassemic patient under deferiprone treatment. | American journal of hematology 20080201 |
| Redistribution of accumulated cell iron: a modality of chelation with therapeutic implications. | Blood 20080201 |
| Relative response of patients with myelodysplastic syndromes and other transfusion-dependent anaemias to deferasirox (ICL670): a 1-yr prospective study. | European journal of haematology 20080201 |
| The heart in transfusion dependent homozygous thalassaemia today--prediction, prevention and management. | European journal of haematology 20080201 |
| Transfusion-dependent thalassaemia: a new era. | The Medical journal of Australia 20080121 |
| Management and clinical outcomes of transfusion-dependent thalassaemia major in an Australian tertiary referral clinic. | The Medical journal of Australia 20080121 |
| Chelator-facilitated removal of iron from transferrin: relevance to combined chelation therapy. | The Biochemical journal 20080115 |
| Nature of non-transferrin-bound iron: studies on iron citrate complexes and thalassemic sera. | Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20080101 |
| Flow cytometry measurement of the labile iron pool in human hematopoietic cells. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20080101 |
| Ethical issues and risk/benefit assessment of iron chelation therapy: advances with deferiprone/deferoxamine combinations and concerns about the safety, efficacy and costs of deferasirox. | Hemoglobin 20080101 |
| Myocyte damage and loss of myofibers is the potential mechanism of iron overload toxicity in congestive cardiac failure in thalassemia. Complete reversal of the cardiomyopathy and normalization of iron load by deferiprone. | Hemoglobin 20080101 |
| Effects of combined deferiprone and deferoxamine chelation therapy on iron load indices in beta-thalassemia. | Hemoglobin 20080101 |
| Immune and neural status of thalassemic patients receiving deferiprone or combined deferiprone and deferoxamine chelation treatment. | Hemoglobin 20080101 |
| Long term comparative studies in thalassemia patients treated with deferoxamine or a deferoxamine/deferiprone combination. Identification of effective chelation therapy protocols. | Hemoglobin 20080101 |
| Effects of chelation therapy on cardiac function improvement in thalassemia patients: literature review and the Taiwanese experience. | Hemoglobin 20080101 |
| A new approach for potential combined chelation therapy using mono- and bis-hydroxypyridinones. | Hemoglobin 20080101 |
| The effects of bicarbonate and its combination with chelating agents used for the removal of depleted uranium in rats. | Hemoglobin 20080101 |
| Chelators controlling metal metabolism and toxicity pathways: applications in cancer prevention, diagnosis and treatment. | Hemoglobin 20080101 |
| Multi-center transferability of a breath-hold T2 technique for myocardial iron assessment. | Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 20080101 |
| Combined chelation therapy in thalassemia major for the treatment of severe myocardial siderosis with left ventricular dysfunction. | Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 20080101 |
| Synthesis, Spectroscopic, and Anticancerous Properties of Mixed Ligand Palladium(II) and Silver(I) Complexes with 4,6-Diamino-5-hydroxy-2-mercaptopyrimidine and 2,2'-Bipyridyl. | Metal-based drugs 20080101 |
| Fatal congestive heart failure with deferiprone. | Gastroenterologie clinique et biologique 20080101 |
| Deferiprone targets aconitase: implication for Friedreich's ataxia treatment. | BMC neurology 20080101 |
| Body iron metabolism and pathophysiology of iron overload. | International journal of hematology 20080101 |
| Improved survival of thalassaemia major in the UK and relation to T2* cardiovascular magnetic resonance. | Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 20080101 |
| Ethical issues and risk/benefit assessment of iron chelation therapy: advances with deferiprone/deferoxamine combinations and concerns about the safety, efficacy and costs of deferasirox [Kontoghiorghes GJ, Hemoglobin 2008; 32(1-2):1-15.]. | Hemoglobin 20080101 |
| Transparency and access to full information for the fatal or serious toxicity risks, low efficacy and high price of deferasirox, could increase the prospect of improved iron chelation therapy worldwide. | Hemoglobin 20080101 |
| Protecting academic freedom. | Open medicine : a peer-reviewed, independent, open-access journal 20080101 |
| MRI evaluation of tissue iron burden in patients with beta-thalassaemia major. | Pediatric radiology 20071201 |
| Pattern of iron chelation therapy in Egyptian beta thalassemic patients: Mansoura University Children's Hospital experience. | Hematology (Amsterdam, Netherlands) 20071201 |
| Effect of an oral iron chelator or iron-deficient diets on uroporphyria in a murine model of porphyria cutanea tarda. | Hepatology (Baltimore, Md.) 20071201 |
| Iron loading and its clinical implications. | American journal of hematology 20071201 |
| Concepts and goals in the management of transfusional iron overload. | American journal of hematology 20071201 |
| Oxidative stress in red blood cells, platelets and polymorphonuclear leukocytes from patients with myelodysplastic syndrome. | European journal of haematology 20071201 |
| Novel treatment options for transfusional iron overload in patients with myelodysplastic syndromes. | Leukemia research 20071201 |
| A randomized controlled 1-year study of daily deferiprone plus twice weekly desferrioxamine compared with daily deferiprone monotherapy in patients with thalassemia major. | Haematologica 20071201 |
| comparison of effects of different long-term iron-chelation regimens on myocardial and hepatic iron concentrations assessed with T2* magnetic resonance imaging in patients with beta-thalassemia major. | International journal of hematology 20071201 |
| Hypoparathyroidism in adult patients with Beta-thalassemia major. | Sultan Qaboos University medical journal 20071201 |
| Lanthanide containing compounds for therapeutic care in bone resorption disorders. | Dalton transactions (Cambridge, England : 2003) 20071121 |
| Deferiprone, an orally deliverable iron chelator, ameliorates experimental autoimmune encephalomyelitis. | Multiple sclerosis (Houndmills, Basingstoke, England) 20071101 |
| pH indicator titration: a novel fast pKa determination method. | Journal of pharmaceutical sciences 20071001 |
| Antiproliferative and apoptotic effects in rat and human hepatoma cell cultures of the orally active iron chelator ICL670 compared to CP20: a possible relationship with polyamine metabolism. | Cell proliferation 20071001 |
| Consequences and costs of noncompliance with iron chelation therapy in patients with transfusion-dependent thalassemia: a literature review. | Transfusion 20071001 |
| Deferiprone: second-line treatment of iron overload in the absence of a better alternative. | Prescrire international 20071001 |
| Deferasirox: for iron overload: only a third-line option. | Prescrire international 20071001 |
| Intensive chelation therapy in beta-thalassemia and possible adverse cardiac effects of desferrioxamine. | International journal of hematology 20071001 |
| Deferiprone in the treatment of transfusion-dependent thalassemia: a review and perspective. | Therapeutics and clinical risk management 20071001 |
| Urinary iron excretion in young thalassemic patients receiving combined chelation treatment with deferoxamine and deferiprone. | Journal of pediatric hematology/oncology 20070901 |
| Hemoglobin is a co-factor of human trypanosome lytic factor. | PLoS pathogens 20070901 |
| Curcumin contributes to in vitro removal of non-transferrin bound iron by deferiprone and desferrioxamine in thalassemic plasma. | Medicinal chemistry (Shariqah (United Arab Emirates)) 20070901 |
| Coordination chemistry and biology of chelators for the treatment of iron overload disorders. | Dalton transactions (Cambridge, England : 2003) 20070814 |
| Iron chelation, quo vadis? | Current opinion in chemical biology 20070801 |
| Light and shadows in the iron chelation treatment of haematological diseases. | British journal of haematology 20070801 |
| Current status of iron overload and chelation with deferasirox. | Indian journal of pediatrics 20070801 |
| Deferasirox: the new oral iron chelator. | Indian pediatrics 20070801 |
| Oral deferiprone for iron chelation in people with thalassaemia. | The Cochrane database of systematic reviews 20070718 |
| Selective iron chelation in Friedreich ataxia: biologic and clinical implications. | Blood 20070701 |
| Fatal agranulocytosis after deferiprone therapy in a child with Diamond-Blackfan anemia. | Blood 20070615 |
| Correction of anemia in a transfusion-dependent patient with primary myelofibrosis receiving iron chelation therapy with deferasirox (Exjade, ICL670). | European journal of haematology 20070601 |
| Pharmacokinetic disposition of the oral iron chelator deferiprone in the white leghorn chicken. | Journal of avian medicine and surgery 20070601 |
| Pharmacokinetic disposition of the oral iron chelator deferiprone in the domestic pigeon (Columba livia). | Journal of avian medicine and surgery 20070601 |
| Exjade(R) (deferasirox, ICL670) in the treatment of chronic iron overload associated with blood transfusion. | Therapeutics and clinical risk management 20070601 |
| Deferasirox: uncertain future following renal failure fatalities, agranulocytosis and other toxicities. | Expert opinion on drug safety 20070501 |
| Epigallocatechin-3-gallate and epicatechin-3-gallate from green tea decrease plasma non-transferrin bound iron and erythrocyte oxidative stress. | Medicinal chemistry (Shariqah (United Arab Emirates)) 20070501 |
| A randomized, placebo-controlled, double-blind trial of the effect of combined therapy with deferoxamine and deferiprone on myocardial iron in thalassemia major using cardiovascular magnetic resonance. | Circulation 20070410 |
| Removal of thallium by combining desferrioxamine and deferiprone chelators in rats. | Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20070401 |
| Evolution of OGTT in patients with beta-thalassaemia major in relation to chelation therapy. | Diabetes research and clinical practice 20070401 |
| Deferiprone: agranulocytosis and neurological disorders. | Prescrire international 20070401 |
| Effects of combined deferiprone and desferrioxamine iron chelating therapy in beta-thalassemia major end-stage heart failure: a case report. | European journal of heart failure 20070301 |
| Chelation therapy for iron overload. | Current gastroenterology reports 20070301 |
| Iron causes interactions of TAK1, p21ras, and phosphatidylinositol 3-kinase in caveolae to activate IkappaB kinase in hepatic macrophages. | The Journal of biological chemistry 20070223 |
| Commentary: Science scandal or ethics scandal? Olivieri redux. | Bioethics 20070201 |
| Reversal of cardiac complications by deferiprone and deferoxamine combination therapy in a patient affected by a severe type of juvenile hemochromatosis (JH). | Blood 20070101 |
| Four-year evaluation of myocardial and liver iron assessed prospectively with serial MRI scans in young patients with beta-thalassaemia major: comparison between different chelation regimens. | European journal of haematology 20070101 |
| Peripheral blood haematopoietic progenitor cells in patients with beta thalassaemia major receiving desferrioxamine or deferiprone as chelation therapy. | European journal of haematology 20070101 |
| Ferrophilic characteristics of Vibrio vulnificus and potential usefulness of iron chelation therapy. | The Journal of infectious diseases 20070101 |
| Red cell adhesion in cerebral malaria. | The Indian journal of medical research 20070101 |
| Recent developments in iron chelation therapy. | Klinische Padiatrie 20070101 |
| Febrile neutropenia and hemorrhagic stroke in a thalassemia major patient. | Hemoglobin 20070101 |
| Normal lumbar bone mineral density in optimally treated children and young adolescents with beta-thalassaemia major. | Hormones (Athens, Greece) 20070101 |
| [Post transfusionnal iron overload]. | La Revue du praticien 20061215 |
| An in vitro study of interactions between insulin-mimetic zinc(II) complexes and selected plasma components. | Journal of inorganic biochemistry 20061201 |
| Physical growth patterns and dental caries in thalassemia. | Indian pediatrics 20061201 |
| Protective effect of monosialoganglioside GM1 against chemically induced apoptosis through targeting of mitochondrial function and iron transport. | Biochemical pharmacology 20061115 |
| Action of chelators in iron-loaded cardiac cells: Accessibility to intracellular labile iron and functional consequences. | Blood 20061101 |
| Deferiprone iron chelation as a novel therapy for experimental mucormycosis. | The Journal of antimicrobial chemotherapy 20061101 |
| Deferasirox and deferiprone remove cardiac iron in the iron-overloaded gerbil. | Translational research : the journal of laboratory and clinical medicine 20061101 |
| Chelation therapy and bone metabolism markers in thalassemia major. | Journal of pediatric endocrinology & metabolism : JPEM 20061101 |
| Deferiprone protects the isolated atria from cardiotoxicity induced by doxorubicin. | Acta pharmacologica Sinica 20061001 |
| Fenton chemistry and iron chelation under physiologically relevant conditions: Electrochemistry and kinetics. | Chemical research in toxicology 20061001 |
| Deferasirox: An effective once-daily orally active iron chelator. | Drugs of today (Barcelona, Spain : 1998) 20061001 |
| Survival of medically treated thalassemia patients in Cyprus. Trends and risk factors over the period 1980-2004. | Haematologica 20060901 |
| A prospective randomized controlled trial on the safety and efficacy of alternating deferoxamine and deferiprone in the treatment of iron overload in patients with thalassemia. | Haematologica 20060901 |
| Effect of enhanced iron chelation therapy on glucose metabolism in patients with beta-thalassaemia major. | British journal of haematology 20060801 |
| Comparative study of the protective effect between deferoxamine and deferiprone on chronic iron overload induced cardiotoxicity in rats. | Human & experimental toxicology 20060701 |
| Isolated thrombocytopenia associated with hydroxyurea/deferiprone (L1) therapy in a sickle beta thalassemia patient. | Haematologica 20060601 |
| Successful recovery of acute hemosiderotic heart failure in beta-thalassemia major treated with a combined regimen of desferrioxamine and deferiprone. | Haematologica 20060601 |
| Effective new treatments of iron overload in thalassaemia using the ICOC combination therapy protocol of deferiprone (L1) and deferoxamine and of new chelating drugs. | Haematologica 20060601 |
| Randomized controlled trial of deferiprone or deferoxamine in beta-thalassemia major patients with asymptomatic myocardial siderosis. | Blood 20060501 |
| Cardiac morbidity and mortality in deferoxamine- or deferiprone-treated patients with thalassemia major. | Blood 20060501 |
| Combined therapy with desferrioxamine and deferiprone in beta thalassemia major patients with transfusional iron overload. | Annals of hematology 20060501 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| Oral chelators deferasirox and deferiprone for transfusional iron overload in thalassemia major: new data, new questions. | Blood 20060501 |
| Monensin improves the effectiveness of meso-dimercaptosuccinate when used to treat lead intoxication in rats. | Environmental health perspectives 20060401 |
| Use of the oral chelator deferiprone in the treatment of iron overload in patients with Hb H disease. | British journal of haematology 20060401 |
| New lipophilic 3-hydroxy-4-pyridinonate iron(III) complexes: synthesis and EXAFS structural characterisation. | Dalton transactions (Cambridge, England : 2003) 20060314 |
| Evaluation of the efficacy of oral deferiprone in beta-thalassemia major by multislice multiecho T2*. | European journal of haematology 20060301 |
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