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304-20-1 | Phthalazine, 1-hydrazinyl-, hydrochloride (1:1)
CAS No: 304-20-1 Catalog No: AG003006 MDL No:MFCD00135998
Product Description
Catalog Number:
AG003006
Chemical Name:
Phthalazine, 1-hydrazinyl-, hydrochloride (1:1)
CAS Number:
304-20-1
Molecular Formula:
C8H9ClN4
Molecular Weight:
196.6369
MDL Number:
MFCD00135998
IUPAC Name:
phthalazin-1-ylhydrazine;hydrochloride
InChI:
InChI=1S/C8H8N4.ClH/c9-11-8-7-4-2-1-3-6(7)5-10-12-8;/h1-5H,9H2,(H,11,12);1H
InChI Key:
ZUXNZUWOTSUBMN-UHFFFAOYSA-N
SMILES:
NNc1nncc2c1cccc2.Cl
EC Number:
206-151-0
UNII:
FD171B778Y
Properties
Complexity:
150
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
196.052g/mol
Formal Charge:
0
Heavy Atom Count:
13
Hydrogen Bond Acceptor Count:
4
Hydrogen Bond Donor Count:
3
Isotope Atom Count:
0
Molecular Weight:
196.638g/mol
Monoisotopic Mass:
196.052g/mol
Rotatable Bond Count:
1
Topological Polar Surface Area:
63.8A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
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| Important role of Rho-kinase in the pathogenesis of cardiovascular inflammation and remodeling induced by long-term blockade of nitric oxide synthesis in rats. | Hypertension (Dallas, Tex. : 1979) 20020201 |
| Effects of dihydropyridine-type Ca2+ antagonists on the renal arterial tree in spontaneously hypertensive rats. | Journal of cardiovascular pharmacology 20020101 |
| Management of heart failure in the elderly. | Heart failure reviews 20020101 |
| L-arginine augments cardiac vagal control in healthy human subjects. | Hypertension (Dallas, Tex. : 1979) 20020101 |
| The renin-angiotensin and adrenergic nervous system in cardiac hypertrophy in fructose-fed rats. | American journal of hypertension 20020101 |
| Nifedipine or hydralazine as a first-line agent to control hypertension in severe preeclampsia. | Acta obstetricia et gynecologica Scandinavica 20020101 |
| Neuroprotective effect of treatment with calcium antagonists on hypertensive retina. | Clinical and experimental hypertension (New York, N.Y. : 1993) 20020101 |
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| The direct effect of insulin on barosensitive neurones in the nucleus tractus solitarii of rats. | Neuroreport 20011204 |
| Effects of angiotensin-converting enzyme inhibition on the development of the atrial fibrillation substrate in dogs with ventricular tachypacing-induced congestive heart failure. | Circulation 20011120 |
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| Changes of retinal neurons and glial fibrillary acid protein immunoreactive astrocytes in spontaneously hypertensive rats. | Journal of hypertension 20011001 |
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| Antihypertensive drugs induce structural remodeling of the penile vasculature. | The Journal of urology 20010801 |
| Persistent cardiovascular effects of chronic renin-angiotensin system inhibition following withdrawal in adult spontaneously hypertensive rats. | Journal of hypertension 20010801 |
| Influence of treatment with Ca(2+) antagonists on cerebral vasculature of spontaneously hypertensive rats. | Mechanisms of ageing and development 20010601 |
| Left ventricular diastolic heart failure with normal left ventricular systolic function in older persons. | The Journal of laboratory and clinical medicine 20010501 |
| Tailored treatments. | Trends in pharmacological sciences 20010501 |
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| Photodynamic therapy with hypericin in a mouse P388 tumor model: vascular effects determine the efficacy. | International journal of oncology 20010401 |
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| Oxytocin antagonist disrupts hypotension-evoked renin secretion and other responses in conscious rats. | American journal of physiology. Regulatory, integrative and comparative physiology 20010301 |
| Influence of hydralazine administration on oxygenation in spontaneous and transplanted tumor models. | International journal of radiation oncology, biology, physics 20010301 |
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| The influence of chronic antihypertensive treatment on the central pressor response in SHR. | Hypertension research : official journal of the Japanese Society of Hypertension 20010301 |
| The generalizability of trial data; a comparison of beta-blocker trial participants with a prospective cohort of women taking beta-blockers in pregnancy. | European journal of obstetrics, gynecology, and reproductive biology 20010201 |
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| Influence of metabolic activation on the induction of micronuclei by antihypertensive drugs in L929 cells. | Archives of toxicology 20010201 |
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| Factor analysis, including antihypertensive medication, of the outcome of pregnancy in pregnancy-associated hypertension. | Kidney & blood pressure research 20010101 |
| Antihypertensive treatment decreased serum leptin levels in severe preeclampsia during pregnancy. | Annals of nutrition & metabolism 20010101 |
| Lisinopril reduces left ventricular hypertrophy and cardiac polyamine concentrations without a reduction in left ventricular wall stress in transgenic Tsukuba hypertensive mice. | Hypertension research : official journal of the Japanese Society of Hypertension 20001101 |
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| Drug-associated antineutrophil cytoplasmic antibody-positive vasculitis: prevalence among patients with high titers of antimyeloperoxidase antibodies. | Arthritis and rheumatism 20000201 |
| The antihypertensive hydralazine is an efficient scavenger of acrolein. | Redox report : communications in free radical research 20000101 |
| Ventricular adrenomedullin levels correlate with the extent of cardiac hypertrophy in rats. | Hypertension (Dallas, Tex. : 1979) 19990501 |
| Urocortin and inflammation: confounding effects of hypotension on measures of inflammation. | Neuroimmunomodulation 19990101 |
| Dissociation of blood pressure reduction from end-organ damage in TGR(mREN2)27 transgenic hypertensive rats. | Journal of hypertension 19981201 |
| The effects of pentobarbital on blood-brain barrier disruption caused by intracarotid injection of hyperosmolar mannitol in rats. | Anesthesia and analgesia 19980601 |
| Regulation of glomerular TGF-beta expression in the contralateral kidney of two-kidney, one-clip hypertensive rats. | Journal of the American Society of Nephrology : JASN 19980501 |
| Investigation of the inhibitory effect of N(G)-nitro-L-arginine methyl ester on the antihypertensive effect of the angiotensin AT1 receptor antagonist, GR138950. | British journal of pharmacology 19971201 |
| Hydralazine inhibits human peritoneal mesothelial cell proliferation and collagen synthesis. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 19961101 |
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| Effect of beraprost sodium, a stable prostacyclin analogue, on pulmonary thromboembolism in mice. | Thrombosis research 19950115 |
| Angiotensin II maintains, but does not mediate, isoproterenol-induced cardiac hypertrophy in rats. | The American journal of physiology 19941001 |
| Management of eclampsia. | Seminars in perinatology 19940401 |
| Hydralazine predisposes to acute cutaneous vasculitis following urography with iopamidol. | The British journal of dermatology 19930701 |
| Alteration of cardiac collagen phenotypes in hypertensive hypertrophy: role of blood pressure. | Journal of molecular and cellular cardiology 19930201 |
| Role of cardiac angiotensin II in isoproterenol-induced left ventricular hypertrophy. | Hypertension (Dallas, Tex. : 1979) 19920601 |
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| Action of hydrazine drugs in tumor-free and 1,2-dimethylhydrazine-treated male rats. | Oncology research 19920101 |
| A comparison of enalapril with hydralazine-isosorbide dinitrate in the treatment of chronic congestive heart failure. | The New England journal of medicine 19910801 |
| Renal arteriolar diameters in spontaneously hypertensive rats. Vascular cast study. | Hypertension (Dallas, Tex. : 1979) 19910701 |
| Effects of hydralazine and increased cardiac output on recombinant tissue plasminogen activator-induced thrombolysis in canine pulmonary embolism. | Chest 19910301 |
| Cocaine intoxication associated with abruptio placentae. | Journal of the National Medical Association 19910301 |
| Cardiotoxicity of hydralazine and minoxidil in the rat. Influence of age. | Research communications in chemical pathology and pharmacology 19910201 |
| Hemodynamic effects of adenosine agonists in the conscious spontaneously hypertensive rat. | The Journal of pharmacology and experimental therapeutics 19900901 |
| Acute cocaine toxicity: antagonism by agents interacting with adrenoceptors. | Pharmacology, biochemistry, and behavior 19900601 |
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| Hydralazine-induced cholestatic jaundice following liver transplantation. | Transplantation 19890101 |
| Antihypertensive effect of felodipine or hydralazine when added to beta-blocker therapy. | Journal of cardiovascular pharmacology 19880701 |
| Additive effects of dihydralazine during enflurane or isoflurane hypotensive anaesthesia for spinal fusion. | Canadian journal of anaesthesia = Journal canadien d'anesthesie 19880501 |
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| Comparative study on the short-term effects of angiotensin converting enzyme inhibitors (Lopirin, SQUIBB and Tensiomin), and dihydralazine in chronic cardiac failure. | Acta physiologica Hungarica 19880101 |
| Sympathetic activity in idiopathic dilated cardiomyopathy. Influence of captopril and hydralazine. | Cardiovascular drugs and therapy 19870801 |
| Reversal by hypothermia of vasodilator-induced tachycardia in anesthetized rats. | Archives internationales de pharmacodynamie et de therapie 19870801 |
| Vasodilators and regression of left ventricular hypertrophy. Hydralazine versus prazosin in hypertensive humans. | The American journal of medicine 19870501 |
| Influence of blood pressure on development of aortic medial smooth muscle hypertrophy in spontaneously hypertensive rats. | Hypertension (Dallas, Tex. : 1979) 19870201 |
| Effect of isoprenaline on tissue elastin content and serum elastolytic activity in normal and hydrazinophthalazine-treated rats. | Biomedica biochimica acta 19870101 |
| Hemodynamic effects of hydralazine in infants with idiopathic dilated cardiomyopathy and congestive heart failure. | American heart journal 19870101 |
| Antihypertensive drugs inhibit hypertension-associated aortic DNA synthesis in the rat. | Hypertension (Dallas, Tex. : 1979) 19861201 |
| Control of hypertension following carotid endarterectomy. | The American surgeon 19861101 |
| Effects of captopril and a combination of hydralazine and isosorbide dinitrate on myocardial sympathetic tone in patients with severe congestive heart failure. | British heart journal 19860801 |
| Therapeutic advantage of converting enzyme inhibitors in arresting progressive renal disease associated with systemic hypertension in the rat. | The Journal of clinical investigation 19860601 |
| Comparative study of endralazine and hydralazine for the treatment of hypertension uncontrolled by a beta-blocker and diuretic. | Current medical research and opinion 19860101 |
| A comparison of the acute hemodynamic effects of prostacyclin and hydralazine in primary pulmonary hypertension. | American heart journal 19851201 |
| Vasodilator effect of indapamide in dog mesenteric vasculature. | Japanese journal of pharmacology 19851101 |
| Effects of hydralazine on pressure-volume and stress-volume relations in congestive heart failure secondary to idiopathic dilated cardiomyopathy. | The American journal of cardiology 19851001 |
| Therapeutic implications of hypertension-induced glomerular injury. Comparison of enalapril and a combination of hydralazine, reserpine, and hydrochlorothiazide in an experimental model. | The American journal of medicine 19850927 |
| Acute hemodynamic effects of pinacidil and hydralazine in essential hypertension. | Clinical pharmacology and therapeutics 19850301 |
| Suppression of ventricular arrhythmias after coronary artery ligation by pinacidil, a vasodilator drug. | Journal of cardiovascular pharmacology 19850101 |
| Effect of hydralazine on serial measurements of exchangeable sodium and blood pressure in spontaneously hypertensive rats. | Clinical and experimental hypertension. Part A, Theory and practice 19850101 |
| Effects of felodipine on resistance and capacitance vessels in patients with essential hypertension. | Drugs 19850101 |
| [Liver lesions induced by dihydralazine and propranolol]. | Zentralblatt fur allgemeine Pathologie u. pathologische Anatomie 19850101 |
| Hydralazine-induced cholangitis. | Gastroenterology 19841101 |
| Combined alpha- and beta-receptor inhibition in the treatment of hypertension. | Drugs 19840101 |
| Comparative actions of hydralazine, nifedipine and amrinone in primary pulmonary hypertension. | The American journal of cardiology 19831101 |
| Simultaneous treatment of Raynaud's phenomenon and orthostatic hypotension. | The American journal of medicine 19830901 |
| Effects of hydralazine on cardiopulmonary function in canine low-pressure pulmonary edema. | Anesthesiology 19830901 |
| Treatment of hypertension associated with head injury. | Journal of neurosurgery 19830901 |
| Hemodynamic responses to combined therapy with captopril and hydralazine in patients with severe heart failure. | Journal of the American College of Cardiology 19830801 |
| Some wrong-way chemical changes during antihypertensive treatment: comparison of indapamide and related agents. | American heart journal 19830701 |
| Vasodilators in the treatment of hypertension. | Comprehensive therapy 19821101 |
| Effects of hydralazine on coronary blood flow and myocardial energetics in congestive heart failure. | Circulation 19820301 |
| Psychiatric side effects of antihypertensive drugs other than reserpine. | Journal of clinical psychopharmacology 19820201 |
| Treatment of hypertensive emergencies of pregnancy. | Clinical pharmacy 19820101 |
| A model for evaluation of postural hypotension induced by drugs in conscious restrained normotensive rats. | Journal of pharmacological methods 19820101 |
| Acute vasodilator therapy increases renal clearance of digoxin in patients with congestive heart failure. | Circulation 19811101 |
| Obstructive jaundice, pancytophenia and hydralazine. | Lancet (London, England) 19810530 |
| Hydralazine-induced hepatitis. | Hepato-gastroenterology 19810201 |
| Pre- and postsynaptic alpha-adrenergic effects of the antihypertensive drug budralazine. | Arzneimittel-Forschung 19810101 |
| Studies in the rat on endralazine, a new antihypertensive drug structurally related to hydralazine. | Clinical and experimental pharmacology & physiology 19810101 |
| Correlation between decreased heart rate and central inhibition of sympathetic discharge after prazosin administration in the spontaneously hypertensive rat. | Clinical and experimental hypertension 19810101 |
| Effect of beta-receptor-blocking agents on cardiovascular structural changes in spontaneous and noradrenaline-induced hypertension in rats. | Clinical science (London, England : 1979) 19801201 |
| Electrophysiologic properties of hydralazine in man. | Pacing and clinical electrophysiology : PACE 19800901 |
| Prospective study of immune response to hydralazine and development of antideoxyribonucleoprotein in patients receiving hydralazine. | The American journal of medicine 19800901 |
| [Hypotensive anaesthesia in the oto-rhino-laryngological surgery using nitroglycerine (author's transl)]. | Der Anaesthesist 19800501 |
| [Rare liver damage caused by an antihypertensive and anti-arrhythmic agents]. | Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete 19800401 |
| Immunological side-effects of antihypertensive drugs. | Acta medica Scandinavica. Supplementum 19790101 |
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| Renal plasma flow and cardiac output during hydralazine and propranolol treatment in essential hypertension. | Scandinavian journal of clinical and laboratory investigation 19780401 |
| Cardiovascular responses to mianserin hydrochloride: a comparison with tricyclic antidepressant drugs. | British journal of clinical pharmacology 19780101 |
| Plasma renin concentration in essential hypertension during beta-adrenergic blockade and vasodilator therapy. | European journal of clinical pharmacology 19771014 |
| Clinical consequences of polymorphic acetylation of basic drugs. | Clinical pharmacology and therapeutics 19770901 |
| Hypotension and bradycardia following diazoxide and hydralazine therapy. | JAMA 19770606 |
| Some side-effects of alpha-methyldopa. | South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 19760410 |
| Induction of antibodies to nuclear antigens in rabbits by immunization with hydralazine-human serum albumin conjugates. | The Journal of clinical investigation 19751001 |
| Long-term treatment of severe hypertension with minoxidil, propranolol and furosemide. | Circulation 19751001 |
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| Use of the sphygmomanometer ASE-1 for the indirect measurement of blood pressure in the rat. | Polish journal of pharmacology and pharmacy 19750101 |
| Letter: Sexual dysfunction due to methyldopa. | British medical journal 19741012 |
| Galactorrhea and Parkinson-like syndrome: an adverse effect of alpha-methyldopa. | Metabolism: clinical and experimental 19701201 |
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