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303776-89-8 | 3-(1,1-Dioxo-1,4-dihydrobenzo[1,2,4]thiadiazin-3-yl)-4-hydroxy-1-(3-methylbutyl)-1H-quinolin-2-one
CAS No: 303776-89-8 Catalog No: AG00C2L7 MDL No:
Product Description
Catalog Number:
AG00C2L7
Chemical Name:
3-(1,1-Dioxo-1,4-dihydrobenzo[1,2,4]thiadiazin-3-yl)-4-hydroxy-1-(3-methylbutyl)-1H-quinolin-2-one
CAS Number:
303776-89-8
IUPAC Name:
3-(1,1-dioxo-4H-1λ6,2,4-benzothiadiazin-3-yl)-4-hydroxy-1-(3-methylbutyl)quinolin-2-one
InChI:
InChI=1S/C21H21N3O4S/c1-13(2)11-12-24-16-9-5-3-7-14(16)19(25)18(21(24)26)20-22-15-8-4-6-10-17(15)29(27,28)23-20/h3-10,13,25H,11-12H2,1-2H3,(H,22,23)
InChI Key:
MQFPIRFODWNQIO-UHFFFAOYSA-N
Properties
Complexity:
827
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
411.125g/mol
Formal Charge:
0
Heavy Atom Count:
29
Hydrogen Bond Acceptor Count:
5
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
411.476g/mol
Monoisotopic Mass:
411.125g/mol
Rotatable Bond Count:
4
Topological Polar Surface Area:
107A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.9
Literature
| Title | Journal |
|---|---|
| Synthesis and biological activity of heteroaryl 3-(1,1-dioxo-2H-(1,2,4)-benzothiadizin-3-yl)-4-hydroxy-2(1H)-quinolinone derivatives as hepatitis C virus NS5B polymerase inhibitors. | Bioorganic & medicinal chemistry letters 20090801 |
| Substituted benzothiadizine inhibitors of Hepatitis C virus polymerase. | Bioorganic & medicinal chemistry letters 20090801 |
| Synergy of a hepatitis C virus (HCV) NS4A antagonist in combination with HCV protease and polymerase inhibitors. | Antimicrobial agents and chemotherapy 20080501 |
| An efficient, asymmetric solid-phase synthesis of benzothiadiazine-substituted tetramic acids: potent inhibitors of the hepatitis C virus RNA-dependent RNA polymerase. | Bioorganic & medicinal chemistry letters 20060415 |
| Control of hepatitis C: a medicinal chemistry perspective. | Journal of medicinal chemistry 20050113 |
| Resistance profile of a hepatitis C virus RNA-dependent RNA polymerase benzothiadiazine inhibitor. | Antimicrobial agents and chemotherapy 20031101 |
| Approaching a new era for hepatitis C virus therapy: inhibitors of the NS3-4A serine protease and the NS5B RNA-dependent RNA polymerase. | Antiviral research 20030301 |
| Identification and biological characterization of heterocyclic inhibitors of the hepatitis C virus RNA-dependent RNA polymerase. | The Journal of biological chemistry 20021011 |
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