200,000+ products from a single source!
sales@angenechem.com
Home > Other Building Blocks > 303-25-3
303-25-3 | Piperazine, 1-(diphenylmethyl)-4-methyl-, hydrochloride (1:1)
CAS No: 303-25-3 Catalog No: AG002ZK0 MDL No:
Product Description
Catalog Number:
AG002ZK0
Chemical Name:
Piperazine, 1-(diphenylmethyl)-4-methyl-, hydrochloride (1:1)
CAS Number:
303-25-3
Molecular Formula:
C18H23ClN2
Molecular Weight:
302.8416
IUPAC Name:
1-benzhydryl-4-methylpiperazine;hydrochloride
InChI:
InChI=1S/C18H22N2.ClH/c1-19-12-14-20(15-13-19)18(16-8-4-2-5-9-16)17-10-6-3-7-11-17;/h2-11,18H,12-15H2,1H3;1H
InChI Key:
UKPBEPCQTDRZSE-UHFFFAOYSA-N
SMILES:
CN1CCN(CC1)C(c1ccccc1)c1ccccc1.Cl
UNII:
W0O1NHP4WE
NSC Number:
169102
Properties
Complexity:
253
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
302.155g/mol
Formal Charge:
0
Heavy Atom Count:
21
Hydrogen Bond Acceptor Count:
2
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
302.846g/mol
Monoisotopic Mass:
302.155g/mol
Rotatable Bond Count:
3
Topological Polar Surface Area:
6.5A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
| Title | Journal |
|---|---|
| The pharmacokinetics and pharmacogenetics of the antiemetic cyclizine in palliative care patients. | Journal of pain and symptom management 20120301 |
| A new cyclizidine analog-JBIR-102-from Saccharopolyspora sp. RL78 isolated from mangrove soil. | The Journal of antibiotics 20120101 |
| Inhibitory effect of homochlorcyclizine on melanogenesis in α-melanocyte stimulating hormone-stimulated mouse B16 melanoma cells. | Archives of pharmacal research 20120101 |
| Quantification of cyclizine and norcyclizine in human plasma by liquid chromatography-tandem mass spectrometry (LC-MS/MS). | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110315 |
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
| Boosting blood flow: intravenous cyclizine in microsurgery. | Plastic and reconstructive surgery 20100901 |
| The cautious use of cyclizine in a patient with myasthenia gravis. | Journal of palliative medicine 20091001 |
| Application of adsorptive voltammetry for the detection of sub-nano molar cyclizine in biological fluids and tablets using fast Fourier transform continuous cyclic voltammetry in a flowing system. | Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20090401 |
| Synthesis and in vitro antiproliferative activity of novel 1-benzhydrylpiperazine derivatives against human cancer cell lines. | European journal of medicinal chemistry 20090301 |
| The misuse/abuse of antihistamine antiemetic medication (cyclizine) by cancer patients. | Palliative medicine 20081001 |
| Mechanistic investigation of N,N-diethyl-4-(phenyl-piperidin-4-ylidenemethyl)-benzamide-induced insulin depletion in the rat and RINm5F cells. | Toxicological sciences : an official journal of the Society of Toxicology 20080901 |
| Management of Ménière's disease in general practice: adherence to the UK National Health Service 'Prodigy' guidelines. | The Journal of laryngology and otology 20080801 |
| Akathisia and an unusual symptomatic treatment: a case report. | Palliative medicine 20071201 |
| Transient paralysis after administration of cyclizine. | Anaesthesia 20061201 |
| A preliminary ecotoxicity study of pharmaceuticals in the marine environment. | Journal of toxicology and environmental health. Part A 20061101 |
| A comparison of cyclizine and granisetron alone and in combination for the prevention of postoperative nausea and vomiting. | Anaesthesia 20061101 |
| Use of intravenous cyclizine in cardiac chest pain. | Emergency medicine journal : EMJ 20060701 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| Best evidence topic report. Use of intravenous cyclizine in cardiac chest pain. | Emergency medicine journal : EMJ 20060101 |
| Acute eosinophilic pneumonia caused by calcium stearate, an additive agent for an oral antihistaminic medication. | Internal medicine (Tokyo, Japan) 20060101 |
| Transient paralysis after administration of a single dose of cyclizine. | Anaesthesia 20051201 |
| An LC-MS-MS method for the determination of cyclizine in human serum. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050925 |
| Effect of (+) or (-) camphorsulfonic acid additives to the mobile phase on enantioseparations of some basic drugs on a Chiralcel OD column. | Journal of chromatography. A 20050812 |
| Percutaneous absorption of cyclizine and its alkyl analogues. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20050201 |
| Improving the acceptability of the atrial defibrillator for the treatment of persistent atrial fibrillation: the atrial defibrillator sedation assessment study (ADSAS). | International journal of cardiology 20040801 |
| The Cyclimorph cough. | Anaesthesia 20040601 |
| Chlorpheniramine maleate as an alternative to antiemetic cyclizine. | Journal of pain and symptom management 20040501 |
| Dystonic reaction to cyclizine. | Anaesthesia 20040401 |
| A capillary zone electrophoresis (CZE) method for the determination of cyclizine hydrochloride in tablets and suppositories. | Journal of pharmaceutical and biomedical analysis 20040401 |
| A response to 'A comparison of cyclizine, ondansetron and placebo as prophylaxis against postoperative nausea and vomiting in children' O'Brien CM, Titley G, Whitehurst P, Anaesthesia 2003; 58: 707-11. | Anaesthesia 20031101 |
| Dystonic reaction to cyclizine. | Anaesthesia 20030901 |
| Dystonic reactions to cyclizine. | Anaesthesia 20030701 |
| A comparison of cyclizine, ondansetron and placebo as prophylaxis against postoperative nausea and vomiting in children. | Anaesthesia 20030701 |
| Prevention of postoperative nausea and vomiting after spinal morphine for Caesarean section: comparison of cyclizine, dexamethasone and placebo. | British journal of anaesthesia 20030501 |
| Cyclizine. | Emergency medicine journal : EMJ 20030501 |
| Histamine H1-receptor antagonists, promethazine and homochlorcyclizine, increase the steady-state plasma concentrations of haloperidol and reduced haloperidol. | Therapeutic drug monitoring 20030401 |
| Probable dystonic reaction after a single dose of cyclizine in a patient with a history of encephalitis. | Anaesthesia 20030301 |
| Biotransformation of cyclizine in greyhounds. 1: Identification and analysis of cyclizine and some basic metabolites in canine urine by gas chromatography-mass spectrometry. | Xenobiotica; the fate of foreign compounds in biological systems 20020901 |
| Biotransformation of cyclizine in greyhounds. 2: N(1)-dealkylation and identification of some neutral and phenolic metabolites in canine urine by gas chromatography-mass spectrometry. | Xenobiotica; the fate of foreign compounds in biological systems 20020901 |
| Comparison of cyclizine and ondansetron for the prevention of postoperative nausea and vomiting in laparoscopic day-case gynaecological surgery. | Anaesthesia 20020101 |
| Cyclizine and droperidol have comparable efficacy and side effects during patient-controlled analgesia. | Irish journal of medical science 20020101 |
| Standard treatment: the role of antihistamines. | The journal of investigative dermatology. Symposium proceedings 20011101 |
| Subcutaneous cyclizine. | Anaesthesia 20010901 |
| Patterns of ergotamine and sumatriptan use in the Netherlands from 1991 to 1997. | Cephalalgia : an international journal of headache 20010601 |
| Postoperative nausea management and patient-controlled analgesia. | British journal of nursing (Mark Allen Publishing) 20010601 |
| Precipitation in Manchester: ketorolac/cyclizine. | Anaesthesia 20010501 |
| Drugs and syringe drivers: a survey of adult specialist palliative care practice in the United Kingdom and Eire. | Palliative medicine 20010301 |
| Impact of an antiemetic protocol on postoperative nausea and vomiting in children. | Paediatric anaesthesia 20010101 |
| Silicone breast implants and drug-induced arthralgia. | Plastic and reconstructive surgery 19970401 |
| The haemodynamic effects of morphine. | Archives of emergency medicine 19880601 |
| [Diazepam in the treatment of children with drug induced extrapyramidal symptoms]. | South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 19790519 |
| Cyclizine-induced chorea. Observations on the influence of cyclizine on dopamine-related movement disorders. | Journal of the neurological sciences 19770301 |
| Cyclizine anaphylaxis, when administered with propanidid. | Anaesthesia 19690101 |
| Studies of drugs given before anaesthesia. X. Two non-phenothiazine anti-emetics--cyclizine and trimethobenzamide. | British journal of anaesthesia 19660101 |
| PHYSIOLOGICAL DISTRIBUTION AND METABOLIC INACTIVATION OF CHLORCYCLIZINE AND CYCLIZINE. | The Journal of pharmacology and experimental therapeutics 19650701 |
Related Products
Featured Products
© 2019 Angene International Limited. All rights Reserved.