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Home > Imidazoles > 301836-41-9
301836-41-9 | 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide
CAS No: 301836-41-9 Catalog No: AG0037OO MDL No:MFCD05865244
Product Description
Catalog Number:
AG0037OO
Chemical Name:
4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide
CAS Number:
301836-41-9
Molecular Formula:
C22H16N4O3
Molecular Weight:
384.3874
MDL Number:
MFCD05865244
IUPAC Name:
4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide
InChI:
InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26)
InChI Key:
FHYUGAJXYORMHI-UHFFFAOYSA-N
SMILES:
NC(=O)c1ccc(cc1)c1[nH]c(c(n1)c1ccc2c(c1)OCO2)c1ccccn1
UNII:
E1557V1V0N
Properties
Complexity:
582
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
384.122g/mol
Formal Charge:
0
Heavy Atom Count:
29
Hydrogen Bond Acceptor Count:
5
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
384.395g/mol
Monoisotopic Mass:
384.122g/mol
Rotatable Bond Count:
4
Topological Polar Surface Area:
103A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.7
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| Smad3 signalling plays an important role in keloid pathogenesis via epithelial-mesenchymal interactions. | The Journal of pathology 20051001 |
| Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells. | Journal of cell science 20051001 |
| Antagonism of transforming growth factor-Beta signaling inhibits fibrosis-related genes. | Biotechnology letters 20051001 |
| ALK5 and Smad4 are involved in TGF-beta1-induced pulmonary endothelial permeability. | FEBS letters 20050718 |
| SB-431542 inhibits TGF-beta-induced contraction of collagen gel by normal and keloid fibroblasts. | Journal of dermatological science 20050701 |
| Smad7 abrogates transforming growth factor-beta1-mediated growth inhibition in COLO-357 cells through functional inactivation of the retinoblastoma protein. | The Journal of biological chemistry 20050610 |
| A specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers. | Neoplasia (New York, N.Y.) 20050501 |
| Brain pericytes contribute to the induction and up-regulation of blood-brain barrier functions through transforming growth factor-beta production. | Brain research 20050321 |
| TGFbeta/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells. | Development (Cambridge, England) 20050301 |
| Selective inhibition of activin receptor-like kinase 5 signaling blocks profibrotic transforming growth factor beta responses in skin fibroblasts. | Arthritis and rheumatism 20041201 |
| A role for Id in the regulation of TGF-beta-induced epithelial-mesenchymal transdifferentiation. | Cell death and differentiation 20041001 |
| SB-431542, a small molecule transforming growth factor-beta-receptor antagonist, inhibits human glioma cell line proliferation and motility. | Molecular cancer therapeutics 20040601 |
| SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptors ALK4, ALK5, and ALK7. | Molecular pharmacology 20040301 |
| Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cells. | The EMBO journal 20040211 |
| SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells. | Cancer research 20031115 |
| Effects of high glucose and TGF-beta1 on the expression of collagen IV and vascular endothelial growth factor in mouse podocytes. | Kidney international 20020901 |
| Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542. | Molecular pharmacology 20020701 |
| SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. | Molecular pharmacology 20020701 |
| Identification of novel inhibitors of the transforming growth factor beta1 (TGF-beta1) type 1 receptor (ALK5). | Journal of medicinal chemistry 20020227 |
| MicroRNA-224 is involved in transforming growth factor-beta-mediated mouse granulosa cell proliferation and granulosa cell function by targeting Smad4. | Molecular endocrinology (Baltimore, Md.) |
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