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Home > Nitro Compounds > 298-83-9
298-83-9 | 2H-Tetrazolium, 2,2'-(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis[3-(4-nitrophenyl)-5-phenyl-, chloride (1:2)
CAS No: 298-83-9 Catalog No: AG0039OO MDL No:MFCD00012159
Product Description
Catalog Number:
AG0039OO
Chemical Name:
2H-Tetrazolium, 2,2'-(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis[3-(4-nitrophenyl)-5-phenyl-, chloride (1:2)
CAS Number:
298-83-9
Molecular Formula:
C40H30Cl2N10O6
Molecular Weight:
817.6356
MDL Number:
MFCD00012159
IUPAC Name:
2-[2-methoxy-4-[3-methoxy-4-[3-(4-nitrophenyl)-5-phenyltetrazol-2-ium-2-yl]phenyl]phenyl]-3-(4-nitrophenyl)-5-phenyltetrazol-2-ium;dichloride
InChI:
InChI=1S/C40H30N10O6.2ClH/c1-55-37-25-29(13-23-35(37)47-43-39(27-9-5-3-6-10-27)41-45(47)31-15-19-33(20-16-31)49(51)52)30-14-24-36(38(26-30)56-2)48-44-40(28-11-7-4-8-12-28)42-46(48)32-17-21-34(22-18-32)50(53)54;;/h3-26H,1-2H3;2*1H/q+2;;/p-2
InChI Key:
FSVCQIDHPKZJSO-UHFFFAOYSA-L
SMILES:
COc1cc(ccc1[n+]1nc(nn1c1ccc(cc1)[N+](=O)[O-])c1ccccc1)c1ccc(c(c1)OC)[n+]1nc(nn1c1ccc(cc1)[N+](=O)[O-])c1ccccc1.[Cl-].[Cl-]
EC Number:
206-067-4
UNII:
X44P41F7ZK
Properties
Complexity:
1180
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
3
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
816.173g/mol
Formal Charge:
0
Heavy Atom Count:
58
Hydrogen Bond Acceptor Count:
12
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
817.644g/mol
Monoisotopic Mass:
816.173g/mol
Rotatable Bond Count:
9
Topological Polar Surface Area:
179A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
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| Changes in the activities and gene expressions of poly(ADP-ribose) glycohydrolases during the differentiation of human promyelocytic leukemia cell line HL-60. | Biochimica et biophysica acta 20040105 |
| Tomato paste fraction inhibiting the formation of advanced glycation end-products. | Bioscience, biotechnology, and biochemistry 20040101 |
| [Neutrophil activation in vitro]. | Tsitologiia 20040101 |
| [Clinical and immunological aspects of cervicitis of chlamydial etiology]. | Zhurnal mikrobiologii, epidemiologii, i immunobiologii 20040101 |
| Antioxidant properties of Aller-7, a novel polyherbal formulation for allergic rhinitis. | Drugs under experimental and clinical research 20040101 |
| A modified Ce/Mg-BCIP-NBT formazan/indigoblue technique for demonstration of non-specific alkaline phosphatase activity. | Cellular and molecular biology (Noisy-le-Grand, France) 20040101 |
| The spontaneous and stimulated nitroblue tetrazolium (NBT) tests in mononuclear cells of patients with tuberculosis. | Roczniki Akademii Medycznej w Bialymstoku (1995) 20040101 |
| Differing phagocytic function of monocytes and neutrophils in Chagas' cardiopathy according to the presence or absence of congestive heart failure. | Revista da Sociedade Brasileira de Medicina Tropical 20040101 |
| Endotoxins of enteric pathogens modulate the functions of human neutrophils and lymphocytes. | Journal of biochemistry and molecular biology 20031130 |
| Severe clinical forms of cytochrome b-negative chronic granulomatous disease (X91-) in 3 brothers with a point mutation in the promoter region of CYBB. | The Journal of infectious diseases 20031115 |
| Self-assembly of Abeta(1-42) into globular neurotoxins. | Biochemistry 20031111 |
| Use of novel assays to indicate that O-esters and S-esters are produced by the same enzyme in brewing yeast. | FEMS microbiology letters 20031107 |
| Arachidonic acid triggers an oxidative burst in leukocytes. | Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20031101 |
| Effects of OPC-6535 on lipopolysaccharide-induced acute liver injury in the rat: involvement of superoxide and tumor necrosis factor-alpha from hepatic macrophages. | Surgery 20031101 |
| Active oxygen species generated from photoexcited fullerene (C60) as potential medicines: O2-* versus 1O2. | Journal of the American Chemical Society 20031022 |
| 6-Hydroxymelatonin protects against cyanide induced oxidative stress in rat brain homogenates. | Journal of chemical neuroanatomy 20031001 |
| A thraustochytrid protist isolated from Mercenaria mercenaria: molecular characterization and host defense responses. | Fish & shellfish immunology 20030901 |
| [State of the blood phagocytic system in the Nitroblue tetrazolium test conducted in clean-up workers following an extended period of time after the Chernobyl nuclear plant accident]. | Klinicheskaia laboratornaia diagnostika 20030701 |
| Comparative cytotoxicity of dimethylamide-crotonin in the promyelocytic leukemia cell line (HL60) and human peripheral blood mononuclear cells. | Toxicology 20030630 |
| Evaluation of the polymorphonuclear cell functions of bottlenose dolphins. | The Journal of veterinary medical science 20030601 |
| A quantitative ELISA-based co-culture angiogenesis and cell proliferation assay. | APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 20030601 |
| Sodium molybdate improves the phagocytic function in alloxan-induced diabetic rats. | Chemico-biological interactions 20030506 |
| NAD(P)H oxidase participates in the signaling events in high glucose-induced proliferation of vascular smooth muscle cells. | Life sciences 20030502 |
| Head kidney neutrophils of carp (Cyprinus carpio L.) are functionally modulated by the haemoflagellateTrypanoplasma borreli. | Fish & shellfish immunology 20030501 |
| Improvement of mupirocin E-test for susceptibility testing of Staphylococcus aureus. | Journal of medical microbiology 20030501 |
| Photochemistry and in vitro phototoxicity studies of levomepromazine (methotrimeprazine), a phototoxic neuroleptic drug. | Die Pharmazie 20030501 |
| [Effect of hydrocortisone on peripheral blood phagocytic cells under beta-adrenoreceptors blockade]. | Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20030501 |
| Violacein and its beta-cyclodextrin complexes induce apoptosis and differentiation in HL60 cells. | Toxicology 20030422 |
| Histone-like proteins from Atlantic cod milt: stimulatory effect on Atlantic salmon leucocytes in vivo and in vitro. | Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20030301 |
| Observing a fictitious stressful event: haematological changes, including circulating leukocyte activation. | Stress (Amsterdam, Netherlands) 20030301 |
| Detection and visualization of oxidase activity in phagocytes. | Methods in molecular biology (Clifton, N.J.) 20030101 |
| NaF induces early differentiation of murine bone marrow cells along the granulocytic pathway but not the monocytic or preosteoclastic pathway in vitro. | In vitro cellular & developmental biology. Animal 20030101 |
| Localisation of NADPH-diaphorase-positive structures in the thymus of the rat, mouse and rabbit. | Folia morphologica 20030101 |
| Potential cidal activity of neutrophilic granulocytes in rabbits immunised with Chlamydia psittaci-Gocaltovo strain. | Polish journal of veterinary sciences 20030101 |
| Utility of the nitroblue tetrazolium reduction test for assessment of reactive oxygen species production by seminal leukocytes and spermatozoa. | Journal of andrology 20030101 |
| [Functional activity of alveolar macrophages in exacerbation of pulmonary tuberculosis]. | Problemy tuberkuleza i boleznei legkikh 20030101 |
| Delayed differentiation of HL-60 cells following exposure to hypoxia. | The Journal of surgical research 20021201 |
| An in-vitro evaluation of lectin cytotoxicity using cell lines derived from the ocular surface. | Journal of drug targeting 20021201 |
| A convenient assay of glycoserum by nitroblue tetrazolium with iodoacetamide. | Clinica chimica acta; international journal of clinical chemistry 20021101 |
| Effects of sodium stibogluconate on differentiation and proliferation of human myeloid leukemia cell lines in vitro. | Leukemia 20021101 |
| Differentiation of human myeloid leukemia cells by plant redifferentiation-inducing hormones. | Leukemia & lymphoma 20020901 |
| Visualization of mosaicism in tissues of normal and mismatch-repair-deficient mice carrying a microsatellite-containing transgene. | Mutation research 20020829 |
| Analysis of tert-butyl hydroperoxide induced constrictions of perfused vascular beds in vitro. | Life sciences 20020802 |
| A comparison of the NADPH oxidase in human sperm and white blood cells. | International journal of andrology 20020801 |
| Costunolide induces differentiation of human leukemia HL-60 cells. | Archives of pharmacal research 20020801 |
| Mechanism of superoxide anion production by hepatic sinusoidal endothelial cells and Kupffer cells during short-term ethanol perfusion in the rat. | Liver 20020801 |
| Superoxide anion production during Anaplasma phagocytophila infection. | The Journal of infectious diseases 20020715 |
| Effects of antioxidants on surfactant peroxidation by stimulated human polymorphonuclear leukocytes. | Free radical research 20020701 |
| Changes in the oxidant-antioxidant balance in the kidney of rats with nephrolithiasis induced by ethylene glycol. | The Journal of urology 20020601 |
| Nod factor induction of reactive oxygen species production is correlated with expression of the early nodulin gene rip1 in Medicago truncatula. | Molecular plant-microbe interactions : MPMI 20020601 |
| Improved viability of latissimus dorsi muscle grafts after electrical prestimulation. | Muscle & nerve 20020501 |
| Chemotaxis, phagocytosis, and oxidative metabolism in bovine macrophages exposed to a novel interdigital phlegmon (foot rot) lesion isolate, Porphyromonas levii. | American journal of veterinary research 20020501 |
| Effects of chronic administration of the novel endothelin antagonist J-104132 on endothelial dysfunction in streptozotocin-induced diabetic rat. | British journal of pharmacology 20020401 |
| A colorimetric assay to quantify dehydrogenase activity in crude cell lysates. | Journal of biomolecular screening 20020401 |
| Metabolism of polyamine oxidation products in plants: localisation of pea aminoaldehyde dehydrogenase activity. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20020401 |
| Production of superoxide anion by head-kidney leucocytes of Indian major carps immunised with bacterins of Aeromonas hydrophila. | Fish & shellfish immunology 20020301 |
| Effects of thermal denaturation on protein glycation. | Life sciences 20020301 |
| In situ staining of activities of enzymes involved in carbohydrate metabolism in plant tissues. | Journal of experimental botany 20020201 |
| Immunostaining of von Willebrand factor multimers on agarose gels and nitrocellulose filters. | Haematologica 20020201 |
| Melatonin and aging: in vitro effect of young and mature ring dove physiological concentrations of melatonin on the phagocytic function of heterophils from old ring dove. | Experimental gerontology 20020101 |
| Control of differentiation and apoptosis of human myeloid leukemia cells by cytokinins and cytokinin nucleosides, plant redifferentiation-inducing hormones. | Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 20020101 |
| Superoxide-superoxide oxidoreductase activity of the captopril-copper complex. | Archives of medical research 20020101 |
| Biochemical assay of superoxide dismutase activity in Drosophila. | Methods in enzymology 20020101 |
| Nickel-containing superoxide dismutase. | Methods in enzymology 20020101 |
| Effect of female sex steroid hormones on the functions of the peripheral blood phagocytizing cells. | Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 20020101 |
| Superoxide dismutase activity and electrochemical study of the binuclear [Cu(TSA)2py]2 complex. | Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 20020101 |
| [State of oxidative metabolism of erythrocytes and neutrophils in patients with vibration disease associated with pneumoconiosis]. | Meditsina truda i promyshlennaia ekologiia 20020101 |
| Reduction of mercuric ion in vitro by superoxide anion. | Physiological chemistry and physics and medical NMR 20020101 |
| Novel esters of glaucarubolone as inducers of terminal differentiation of promyelocytic HL-60 cells and inhibitors of 7,12-dimethylbenz[a]anthracene-induced preneoplastic lesion formation in mouse mammary organ culture. | Journal of natural products 20011201 |
| Isolation and characterization of an active compound from black soybean [Glycine max (L.) Merr.] and its effect on proliferation and differentiation of human leukemic U937 cells. | Anti-cancer drugs 20011101 |
| Luminol chemiluminescence in unbuffered solutions with a cobalt(II)-ethanolamine complex immobilized on resin as catalyst and its application to analysis. | Analytical chemistry 20011101 |
| Restriction-mediated differential display (RMDD). | Current protocols in molecular biology 20011101 |
| 5-aminoisoquinolinone, a potent inhibitor of poly (adenosine 5'-diphosphate ribose) polymerase, reduces myocardial infarct size. | European journal of pharmacology 20011026 |
| Electroacupuncture-related changes of NADPH-diaphorase and neuronal nitric oxide synthase in the brainstem of spontaneously hypertensive rats. | Neuroscience letters 20011019 |
| A sequential protocol combining dual neuroanatomical tract-tracing with the visualization of local circuit neurons within the striatum. | Journal of neuroscience methods 20011015 |
| Effects of hydrocortisone on peritoneal phagocytizing cells in rats under conditions of beta-adrenoceptors blockade. | Bulletin of experimental biology and medicine 20011001 |
| Stability of nitroblue tetrazolium-based alkaline phosphatase substrates. | The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20010901 |
| Histochemical localization of glutathione dependent NBT-reductase in mouse skin. | Biomedical and environmental sciences : BES 20010901 |
| Porphyromonas endodontalis binds, reduces and grows on human hemoglobin. | Oral microbiology and immunology 20010801 |
| Altered mitochondrial function and overgeneration of reactive oxygen species precede the induction of apoptosis by 1-O-octadecyl-2-methyl-rac-glycero-3-phosphocholine in p53-defective hepatocytes. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010801 |
| Measurement of MnSOD and CuZnSOD activity in mammalian tissue homogenates. | Current protocols in toxicology 20010801 |
| Leukotoxicity of pyoverdin, production of reactive oxygen species, and effect of UV radiation. | Biochemical and biophysical research communications 20010713 |
| Cisplatin ototoxicity: involvement of iron and enhanced formation of superoxide anion radicals. | Toxicology and applied pharmacology 20010701 |
| Immunosuppressive effects of aflatoxin B1 in Indian major carp (Labeo rohita). | Comparative immunology, microbiology and infectious diseases 20010701 |
| Human alveolar macrophage phagocytic function is impaired by aggregates of ultrafine carbon particles. | Environmental research 20010701 |
| [Partially hydrogenated aryl-1,2/1,4-anthraquinone derivatives, 5-lipoxygenase inhibitors with arotinoid structure]. | Die Pharmazie 20010701 |
| Dopa decarboxylase exhibits low pH half-transaminase and high pH oxidative deaminase activities toward serotonin (5-hydroxytryptamine). | Protein science : a publication of the Protein Society 20010601 |
| Inhibition of oxidative burst and chemotaxis in human phagocytes by Legionella pneumophila zinc metalloprotease. | Journal of medical microbiology 20010601 |
| Synergistic effects of highly unsaturated fatty acid-containing phosphatidyl-ethanolamine on differentiation of human leukemia HL-60 cells by dibutyryl cyclic adenosine monophosphate. | Japanese journal of cancer research : Gann 20010601 |
| The reduction of nitroblue tetrazolium by red blood cells: a measure of Red Cell membrane antioxidant capacity and hemoglobin-membrane binding sites. | Free radical research 20010601 |
| Peripheral blood granulocyte activity following contact sensitization of rats with dinitrochlorobenzene. | Toxicology 20010511 |
| The effect of a short-term mental stressor on neutrophil activation. | International journal of psychophysiology : official journal of the International Organization of Psychophysiology 20010501 |
| Targeted disruption of the nitric oxide synthase 2 gene protects against ischaemia/reperfusion injury to skeletal muscle. | The Journal of pathology 20010501 |
| Cell differentiation and apoptosis of monocytic and promyelocytic leukemia cells (U-937 and HL-60) by tryptanthrin, an active ingredient of Polygonum tinctorium Lour. | Pathology international 20010501 |
| Tumor necrosis factor alpha (TNFalpha)-like factor produced by macrophages in rainbow trout, Oncorhynchus mykiss. | Fish & shellfish immunology 20010401 |
| Immunohistochemical localization of osteopontin in human pulp stones. | Journal of endodontics 20010401 |
| An iron-regulated ferric reductase associated with the absorption of dietary iron. | Science (New York, N.Y.) 20010302 |
| In-gel detection of urease with nitroblue tetrazolium and quantification of the enzyme from different crop plants using the indophenol reaction. | Analytical biochemistry 20010301 |
| Cytotoxicity of derivatives from dehydrocrotonin on V79 cells and Escherichia coli. | Toxicology 20010227 |
| A simple technique for the simultaneous determination of molecular weight and activity of superoxide dismutase using SDS-PAGE. | Journal of biochemical and biophysical methods 20010226 |
| Nickel, cobalt and chromium-induced cytotoxicity and intracellular accumulation in human hacat keratinocytes. | Toxicology 20010221 |
| Induction of differentiation of human myeloid leukemia cells by novel synthetic neurotrophic pyrimidine derivatives. | Experimental hematology 20010201 |
| Clinical value of fructosamine measurements in non-healthy dogs. | Veterinary research communications 20010201 |
| Rac2 is an essential regulator of neutrophil nicotinamide adenine dinucleotide phosphate oxidase activation in response to specific signaling pathways. | Journal of immunology (Baltimore, Md. : 1950) 20010115 |
| Microglial reaction in focal cerebral ischaemia induced by intra-carotid homologous clot injection. | Histology and histopathology 20010101 |
| Photosensitizing activity of thiocolchicoside: photochemical and in vitro phototoxicity studies. | Die Pharmazie 20010101 |
| Scapular insertion of the rabbit latissimus dorsi muscle: gross anatomy and fibre-type composition. | Cells, tissues, organs 20010101 |
| Discovery of novel inducers of cellular differentiation using HL-60 promyelocytic cells. | Anticancer research 20010101 |
| Application of the nitroblue tetrazolium-reduction method for studies on the production of reactive oxygen species in insect haemocytes. | Cytobios 20010101 |
| Measurement of the viability of arbuscular-mycorrhizal fungi using three different stains; relation to growth and metabolic activities of soybean plants. | Microbiological research 20010101 |
| Macrophages are essential for lymphocyte infiltration in formyl peptide-induced cholangitis in rat liver. | Liver 19990601 |
| Inhibition of nitrergic neurotransmission in the bovine retractor penis muscle by an oxidant stress: effects of superoxide dismutase mimetics. | British journal of pharmacology 19980501 |
| A simple method to identify NBT-positive cells in isolated glomeruli. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 19970101 |
| Effects of oxygen radical scavengers on connexins 32 and 26 expression in primary cultures of adult rat hepatocytes. | Carcinogenesis 19960301 |
| Differentiation of human monoblastic leukemia U937 cells induced by inhibitors of myosin light chain kinase and prevention of differentiation by granulocyte-macrophage colony-stimulating factor. | Biochimica et biophysica acta 19930416 |
| Mitochondrial regulation of superoxide by Ca2+: an alternate mechanism for the cardiotoxicity of doxorubicin. | Toxicology and applied pharmacology 19910101 |
| [The NBT test in bacterial infections complicating prednisone-treated nephrotic syndrome]. | Wiadomosci lekarskie (Warsaw, Poland : 1960) 19890301 |
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