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Home > Nitro Compounds > 29606-02-8

29606-02-8

29606-02-8 | Guanidine, N'-methyl-N-nitro-N-nitroso-

CAS No: 29606-02-8 Catalog No: AG002YVV MDL No:

Product Description

Catalog Number:
AG002YVV
Chemical Name:
Guanidine, N'-methyl-N-nitro-N-nitroso-
CAS Number:
29606-02-8
Molecular Formula:
C2H5N5O3
Molecular Weight:
147.0928
IUPAC Name:
2-methyl-1-nitro-1-nitrosoguanidine
InChI:
InChI=1S/C2H5N5O3/c1-4-2(3)6(5-8)7(9)10/h1H3,(H2,3,4)
InChI Key:
ZVGCIMVMXFUSDB-UHFFFAOYSA-N
SMILES:
O=NN(C(=N)NC)[N+](=O)[O-]

Properties

Complexity:
170  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
147.039g/mol
Formal Charge:
0
Heavy Atom Count:
10  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
147.094g/mol
Monoisotopic Mass:
147.039g/mol
Rotatable Bond Count:
1  
Topological Polar Surface Area:
117A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-0.3  

Literature

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Effects of aqueous extracts of medicinal plants on MNNG-treated rat hepatocytes in primary cultures. Journal of ethnopharmacology 20070530
Protein tyrosine nitration and poly(ADP-ribose) polymerase activation in N-methyl-N-nitro-N-nitrosoguanidine-treated thymocytes: implication for cytotoxicity. Toxicology letters 20070515
Chemical carcinogen, N-methyl-N'-nitro-N-nitrosoguanidine, is a specific activator of oncogenic Ras. Cell cycle (Georgetown, Tex.) 20070515
Modulatory effects of black tea polyphenols on oxidant-antioxidant profile and expression of proliferation, apoptosis, and angiogenesis-associated proteins in the rat forestomach carcinogenesis model. Journal of gastroenterology 20070501
Heat shock does not induce gammaH2AX foci formation but protects cells from N-methyl-N'-nitro-N-nitrosoguanidine-induced genotoxicity. Mutation research 20070420
Development of a new E. coli strain to detect oxidative mutation and its application to the fungicide o-phenylphenol and its metabolites. Mutation research 20070402
Genotoxic effects in M5 cells and Chinese hamster V79 cells after exposure to 7Li-beam (LET=60 keV/microm) and correlation of their survival dynamics to nuclear damages and cell death. Mutation research 20070330
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The involvement of ATP produced via (ADP-Ribose)n in the maintenance of DNA replication apparatus during DNA repair. Biological & pharmaceutical bulletin 20070301
Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults. Biochemical pharmacology 20070215
Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2. The Journal of biological chemistry 20070202
Progression of tumors arising from large ACF is associated with the MUC5AC expression during rat colon MNNG carcinogenis. International journal of cancer 20070201
Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine. Oncogene 20070111
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Human monocytes, but not dendritic cells derived from them, are defective in base excision repair and hypersensitive to methylating agents. Cancer research 20070101
Enhanced vanillin production from recombinant E. coli using NTG mutagenesis and adsorbent resin. Biotechnology progress 20070101
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Mutagenic effect of cadmium on tetranucleotide repeats in human cells. Mutation research 20061201
Methylating agents and DNA repair responses: Methylated bases and sources of strand breaks. Chemical research in toxicology 20061201
MNNG-induced cell death is controlled by interactions between PARP-1, poly(ADP-ribose) glycohydrolase, and XRCC1. The Journal of biological chemistry 20061110
DBA/2 mouse skin is unresponsive to dermal tumor promotion by cigarette smoke condensate. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20061101
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Treatment of gastric precancerous lesions with Weiansan. World journal of gastroenterology 20060907
A comparative study of using comet assay and gammaH2AX foci formation in the detection of N-methyl-N'-nitro-N-nitrosoguanidine-induced DNA damage. Toxicology in vitro : an international journal published in association with BIBRA 20060901
Carcinogen-induced DNA double strand break repair in sporadic breast cancer. The Journal of surgical research 20060901
Chemopotentiating effects of a novel NAD biosynthesis inhibitor, FK866, in combination with antineoplastic agents. European journal of medical research 20060830
Xrcc2 deficiency sensitizes cells to apoptosis by MNNG and the alkylating anticancer drugs temozolomide, fotemustine and mafosfamide. Cancer letters 20060808
Comparative evaluation of the alkaline comet assay with the micronucleus test for genotoxicity monitoring using aquatic organisms. Ecotoxicology and environmental safety 20060701
EndoG is dispensable in embryogenesis and apoptosis. Cell death and differentiation 20060701
ATM activation by a sulfhydryl-reactive inflammatory cyclopentenone prostaglandin. Genes to cells : devoted to molecular & cellular mechanisms 20060701
Poly(ADP-ribose) glycohydrolase silencing protects against H2O2-induced cell death. The Biochemical journal 20060615
Effects of co-exposure to extremely low frequency (50 Hz) magnetic fields and xenobiotics determined in vitro by the alkaline comet assay. The Science of the total environment 20060515
dUTP Pyrophosphatase, its appearance in extracellular compartment may serve as a potential biomarker for N-methyl-N'-nitro-N-nitrosoguanidine exposure in mammalian cells. Proteomics 20060501
ATR-Chk1 axis protects BCR/ABL leukemia cells from the lethal effect of DNA double-strand breaks. Cell cycle (Georgetown, Tex.) 20060501
Induced endoplasmic reticulum (ER) stress and binding of over-expressed ER specific chaperone GRP78/BiP with dimerized epidermal growth factor receptor in mammalian cells exposed to low concentration of N-methyl-N'-nitro-N-nitrosoguanidine. Mutation research 20060411
Specificity of replicative and SOS-inducible DNA polymerases in frameshift mutagenesis: mutability of Salmonella typhimurium strains overexpressing SOS-inducible DNA polymerases to 30 chemical mutagens. DNA repair 20060408
Strain improvement for tannase production from co-culture of Aspergillus foetidus and Rhizopus oryzae. Bioresource technology 20060401
The effect of a mutagen (N-methyl-N-nitro-N-nitrosoguanidine) on cultured cells from adult Schistosoma japonicum. Parasitology research 20060401
[The role of JWA in N-methyl-N'-nitro-N-nitrosoguanidine induced human bronchial epithelial cell apoptosis]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20060401
A slipped-mispairing mutation in AgrA of laboratory strains and clinical isolates results in delayed activation of agr and failure to translate delta- and alpha-haemolysins. Molecular microbiology 20060301
Dose-dependent promotion of rat forestomach carcinogenesis by combined treatment with sodium nitrite and ascorbic acid after initiation with N-methyl-N'-nitro-N-nitrosoguanidine: possible contribution of nitric oxide-associated oxidative DNA damage. Cancer science 20060301
A flow cytometry-optimized assay using an SOS-green fluorescent protein (SOS-GFP) whole-cell biosensor for the detection of genotoxins in complex environments. Mutation research 20060227
Methylation of the O6-methylguanine-DNA methyltransferase promoter suppresses expression in mouse skin tumors and varies with the tumor induction protocol. International journal of cancer 20060201
Proteomic profiling for cellular responses to different concentrations of N-methyl-N'-nitro-N-nitrosoguanidine. Journal of proteome research 20060201
Inhibitory effects of caraway (Carum carvi L. ) and its component on N-methyl-N'-nitro-N-nitrosoguanidine-induced mutagenicity. The journal of medical investigation : JMI 20060201
Strain improvement of Candida tropicalis for the production of xylitol: biochemical and physiological characterization of wild-type and mutant strain CT-OMV5. Journal of microbiology (Seoul, Korea) 20060201
Mutagenesis. Methods in molecular biology (Clifton, N.J.) 20060101
Chemopreventive effects of rofecoxib and folic acid on gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in rats. Chinese journal of digestive diseases 20060101
Dermatological effects of chronic exposure to 7,12-dimethylbenz[A]anthracene (DMBA) or N-methyl-N-nitrosoguanidine (MNNG) in swine. Cutaneous and ocular toxicology 20060101
Inhibition of N-Methyl N'-nitro-N-nitrosoguanidine (MNNG) induced gastric carcinogenesis by Phyllanthus amarus extract. Asian Pacific journal of cancer prevention : APJCP 20060101
DNA damage and L1 retrotransposition. Journal of biomedicine & biotechnology 20060101
Helicobacter pylori infection can modulate the susceptibility of gastric mucosa cells to MNNG. Cellular & molecular biology letters 20060101
[Chemically methylated DNA repair in Escherichia coli--the role of alkB protein]. Postepy biochemii 20060101
Imatinib (STI571) inhibits DNA repair in human leukemia oncogenic tyrosine kinase-expressing cells. Zeitschrift fur Naturforschung. C, Journal of biosciences 20060101
Targeting of O6-MeG DNA methyltransferase (MGMT) to mitochondria protects against alkylation induced cell death. Mitochondrion 20051201
Isolation and proteomic analysis [corrected] of cell wall-deficient Haematococcus pluvialis mutants. Proteomics 20051201
Biochemical characterization of N-methyl N'-nitro-N-nitrosoguanidine-induced cadmium resistant mutants of Aspergillus niger. Journal of biosciences 20051201
Function of domains of human O6-alkylguanine-DNA alkyltransferase. Biochemistry 20051122
Role of O6-methylguanine-DNA methyltransferase and effect of O6-benzylguanine on the anti-tumor activity of cis-diaminedichloroplatinum(II) in oral cancer cell lines. Oral oncology 20051101
Genotoxicity of nicotine in mini-organ cultures of human upper aerodigestive tract epithelia. Toxicological sciences : an official journal of the Society of Toxicology 20051101
Differential effects of cisplatin and MNNG on dna mutants of Escherichia coli. Mutation research 20051015
N-methyl-N'-nitro-N-nitrosoguanidine activates cell-cycle arrest through distinct mechanisms activated in a dose-dependent manner. Molecular pharmacology 20051001
Global genomic changes induced by two-stage carcinogen exposure are precancerous alterations in non-transformed human liver epithelial THLE-3 cells. International journal of oncology 20051001
Antimutagenic and anti-oxidant activities of the non-steroidal anti-inflammatory drug celecoxib. Clinical and experimental pharmacology & physiology 20051001
Interstitial telomeric DNA sequences of Chinese hamster cells are hypersensitive to nitric oxide damage, and DNA-PKcs has a specific local role in its repair. Genes, chromosomes & cancer 20050901
Apaf-1 deficient mouse fibroblasts are resistant to MNNG and MMS-induced apoptotic death without attenuation of Bcl-2 decline. Toxicology and applied pharmacology 20050901
Homologous recombination rescues mismatch-repair-dependent cytotoxicity of S(N)1-type methylating agents in S. cerevisiae. Current biology : CB 20050809
Histological and ultrastructural changes induced by selenium in early experimental gastric carcinogenesis. World journal of gastroenterology 20050807
Assay to measure CD59 mutations in CHO A(L) cells using flow cytometry. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20050801
NADH can enter into astrocytes and block poly(ADP-ribose) polymerase-1-mediated astrocyte death. Neuroreport 20050801
Combination of S-allylcysteine and lycopene induces apoptosis by modulating Bcl-2, Bax, Bim and caspases during experimental gastric carcinogenesis. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 20050801
A lipidomic study of the effects of N-methyl-N'-nitro-N-nitrosoguanidine on sphingomyelin metabolism. Acta biochimica et biophysica Sinica 20050801
Tankyrase-1 overexpression reduces genotoxin-induced cell death by inhibiting PARP1. Molecular and cellular biochemistry 20050801
[Cell proliferation inhibitive and apoptosis promoting effects of sanchi extract on GES-1 cell after being transformed by MNNG]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20050801
Antimutagenicity and DT-diaphorase inducing activity of Gynostemma pentaphyllum Makino extract. The journal of medical investigation : JMI 20050801
Genome-wide screen identifies genes whose inactivation confer resistance to cisplatin in Saccharomyces cerevisiae. Cancer research 20050701
Whole-genome analyses of loss of heterozygosity and methylation analysis of four tumor-suppressor genes in N-methyl-N'-nitro-N-nitrosoguanidine-induced rat stomach carcinomas. Cancer science 20050701
Screening of potential lactobacilli antigenotoxicity by microbial and mammalian cell-based tests. International journal of food microbiology 20050625
Induction of apoptosis and inhibition of cyclooxygenase-2 expression by N-methyl-N'-nitro-N-nitrosoguanidine in human leukemia cells. Anti-cancer drugs 20050601
Sphingolipids are involved in N-methyl-N'-nitro-N-nitrosoguanidine-induced epidermal growth factor receptor clustering. Biochemical and biophysical research communications 20050506
Nuclear poly(ADP-ribose) polymerase-1 rapidly triggers mitochondrial dysfunction. The Journal of biological chemistry 20050429
Role of Helicobacter pylori in gastric carcinogenesis: the origin of gastric cancers and heterotopic proliferative glands in Mongolian gerbils. Helicobacter 20050401
Attenuation of N-methyl-N'-nitro-N-nitrosoguanidine induced genotoxicity and oxidative stress by tomato and garlic combination. Life sciences 20050325
High doses of SN1 type methylating agents activate DNA damage signaling cascades that are largely independent of mismatch repair. Cell cycle (Georgetown, Tex.) 20050301
N-methyl-N'-nitro-N-nitrosoguanidine interferes with the epidermal growth factor receptor-mediated signaling pathway. Mutation research 20050301
The alkylating carcinogen N-methyl-N'-nitro-N-nitrosoguanidine activates the plasminogen activator inhibitor-1 gene through sequential phosphorylation of p53 by ATM and ATR kinases. Thrombosis and haemostasis 20050301
Modulation effect of tea polyphenol toward N-methyl-N'-nitro-N-nitrosoguanidine-induced precancerous gastric lesion in rats. The Journal of nutritional biochemistry 20050301
[Apoptosis-promoting effect of Panax notoginseng extracts on MNNG-transformed GES-1 cells]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20050301
[Gene expression profiles in early stage of BALB/c 3T3 cells' transformation promoted with 12-O-tetradecanoylphorbol-13-acetate]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 20050301
NAD+ as a metabolic link between DNA damage and cell death. Journal of neuroscience research 20050101
Evaluation of the anti-genotoxicity of leaf extract of Ashwagandha. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20050101
The monofunctional alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine triggers apoptosis through p53-dependent and -independent pathways. Toxicology and applied pharmacology 20050101
Polyamines modulate carcinogen-induced mutagenesis in vivo. Environmental and molecular mutagenesis 20050101
Novel mutation method for increased cellulase production. Journal of applied microbiology 20050101
[Modification of mutation processes in culture of human lymphocytes with tea extracts]. TSitologiia i genetika 20050101
Symbiotic effectiveness of a siderophore overproducing mutant of Mesorhizobium ciceri. Polish journal of microbiology 20050101
Combination chemoprevention of experimental gastric carcinogenesis by s-allylcysteine and lycopene: modulatory effects on glutathione redox cycle antioxidants. Journal of medicinal food 20050101
TDP1 overexpression in human cells counteracts DNA damage mediated by topoisomerases I and II. The Journal of biological chemistry 20041231
N-methyl-N'-nitro-N-nitrosoguanidine sensitivity, mutator phenotype and sequence specificity of spontaneous mutagenesis in FEN-1-deficient cells. Mutation research 20041122
MNNG-induced mutations in the adult gill and hepatopancreas and in embryos of rpsL transgenic zebrafish. Mutation research 20041122
BCR/ABL recruits p53 tumor suppressor protein to induce drug resistance. Cell cycle (Georgetown, Tex.) 20041101
[Inhibiting effects of Panax notoginseng extracts on proliferation of GES-1 cells and MNNG-transformed GES-1 cells]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20041101
Induction of apoptosis and G2/M arrest by N-methyl-N'-nitro-N-nitrosoguanidine in human prostate carcinoma cells. Mutation research 20041010
In vivo detection of gastric cancer in rats by electron paramagnetic resonance imaging. Cancer research 20040915
Protective effect of tomato against N-methyl-N'-nitro-N-nitrosoguanidine-induced in vivo clastogenicity and oxidative stress. Nutrition (Burbank, Los Angeles County, Calif.) 20040901
Characterization of Streptomyces scabies mutants deficient in melanin biosynthesis. Canadian journal of microbiology 20040901
Poly(ADP-ribose) glycohydrolase as a target for neuroprotective intervention: assessment of currently available pharmacological tools. European journal of pharmacology 20040816
Transient adenoviral N-methylpurine DNA glycosylase overexpression imparts chemotherapeutic sensitivity to human breast cancer cells. Molecular cancer therapeutics 20040801
Effects of estrogens and metabolites on endometrial carcinogenesis in young adult mice initiated with N-ethyl-N'-nitro-N-nitrosoguanidine. Cancer letters 20040728
Induction of the mitochondrial permeability transition by the DNA alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine. Sorting cause and consequence of mitochondrial dysfunction. Biochimica et biophysica acta 20040723
An investigation of the genotoxic effects of N-nitrosomorpholine in mammalian cells. Chemico-biological interactions 20040720
Anti-genotoxicity of coffee against N-methyl-N-nitro-N-nitrosoguanidine in mouse lymphoma cells. Mutation research 20040711
The use of mini-organ cultures of human upper aerodigestive tract epithelia in ecogenotoxicology. Mutation research 20040711
Depleted dopamine in gastric cancer tissues: dopamine treatment retards growth of gastric cancer by inhibiting angiogenesis. Clinical cancer research : an official journal of the American Association for Cancer Research 20040701
Down-regulation of mitotic checkpoint in transformed human embryo lung fibroblasts induced by N-methyl-N'-nitro-N-nitrosoguaridine. Chinese medical journal 20040701
Response of REV3 promoter to N-methyl-N'-nitro-N-nitrosoguanidine. Mutation research 20040604
Citric acid production by selected mutants of Aspergillus niger from cane molasses. Bioresource technology 20040601
Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase. Genes & development 20040601
Persistence of gene expression changes in stomach mucosae induced by short-term N-methyl-N'-nitro-N-nitrosoguanidine treatment and their presence in stomach cancers. Mutation research 20040518
Effect of duodenogastric reflux on N-methyl-N'-nitro-N-nitrosoguanidine-induced glandular stomach tumorigenesis in Helicobacter pylori-infected Mongolian gerbils. Oncology reports 20040501
Chemopreventive effects of hydroxymatairesinol on uterine carcinogenesis in Donryu rats. Experimental biology and medicine (Maywood, N.J.) 20040501
Construction and characterization of novel dual stress-responsive bacterial biosensors. Biosensors & bioelectronics 20040415
Apoptotic signaling in response to a single type of DNA lesion, O(6)-methylguanine. Molecular cell 20040409
Introduction of human telomerase reverse transcriptase to normal human fibroblasts enhances DNA repair capacity. Clinical cancer research : an official journal of the American Association for Cancer Research 20040401
Directly fishing out subtle mutations in genomic DNA with histidine-tagged Thermus thermophilus MutS. Mutation research 20040322
Enhanced stimulation of chromosomal translocations by radiomimetic DNA damaging agents and camptothecin in Saccharomyces cerevisiae rad9 checkpoint mutants. Mutation research 20040322
An Escherichia coli biosensor capable of detecting both genotoxic and oxidative damage. Applied microbiology and biotechnology 20040301
Coffee-mediated protective effects against directly acting genotoxins and gamma-radiation in mouse lymphoma cells. Cell biology and toxicology 20040301
Chemoprevention of gastric cancer by celecoxib in rats. Gut 20040201
Protective effects of ethanolic neem leaf extract on N-methyl-N'-nitro-N-nitrosoguanidine-induced genotoxicity and oxidative stress in mice. Drug and chemical toxicology 20040201
Apoptosis triggered by DNA damage O6-methylguanine in human lymphocytes requires DNA replication and is mediated by p53 and Fas/CD95/Apo-1. Oncogene 20040115
Msh2 deficiency does not contribute to cisplatin resistance in mouse embryonic stem cells. Oncogene 20040108
Cyclin D1 expression and cell cycle response in DNA mismatch repair-deficient cells upon methylation and UV-C damage. Experimental cell research 20040101
N-methyl-N'-nitro-N-nitrosoguanidine-induced senescence-like growth arrest in colon cancer cells is associated with loss of adenomatous polyposis coli protein, microtubule organization, and telomeric DNA. Molecular cancer 20040101
Comparative genomic hybridization analysis of N-methyl-N'-nitrosoguanidine-induced rat gastrointestinal tumors discloses a cytogenetic fingerprint. Environmental and molecular mutagenesis 20040101
Proteomic analysis of cellular responses to low concentration N-methyl-N'-nitro-N-nitrosoguanidine in human amnion FL cells. Environmental and molecular mutagenesis 20040101
Improvement of carotenoid-synthesizing yeast Rhodotorula rubra by chemical mutagenesis. Zeitschrift fur Naturforschung. C, Journal of biosciences 20040101
Anti-stress activity of Propionibacterium freudenreichii : identification of a reactivative protein. Antonie van Leeuwenhoek 20040101
Nickel impairs the repair of UV- and MNNG-damaged DNA. Cellular & molecular biology letters 20040101
Protective effect of S-allylcysteine and lycopene in combination against N-methyl-N'-nitro-N-nitrosoguanidine-induced genotoxicity. Polish journal of pharmacology 20040101
Induction of deoxyribonucleic acid damage by alkylating agents. Methods in molecular biology (Clifton, N.J.) 20040101
Prevention and repair of DNA damage by selected phytochemicals as measured by single cell gel electrophoresis. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20040101
Effects of aqueous extracts of garlic (Allium sativum) and neem (Azadirachta indica) leaf on hepatic and blood oxidant-antioxidant status during experimental gastric carcinogenesis. Journal of medicinal food 20040101
Proteome analysis of gastric cancer metastasis by two-dimensional gel electrophoresis and matrix assisted laser desorption/ionization-mass spectrometry for identification of metastasis-related proteins. Journal of proteome research 20040101
Differences in responses of plant hairy roots to chemical toxicity compared between primary and ramified roots. Environmental sciences : an international journal of environmental physiology and toxicology 20040101
[Increasing biosynthesis of avermectins of Streptomyces avermitilis UCM Ac 2161 under the effect N-methyl-N'-nitro-N-nitrosoguanidine]. Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993) 20040101
N-methyl-N'-nitro-N-nitrosoguanidine. Report on carcinogens : carcinogen profiles 20040101
beta-Catenin mutations and nuclear accumulation during progression of rat stomach adenocarcinomas. Cancer science 20031201
Mismatch repair-dependent transcriptome changes in human cells treated with the methylating agent N-methyl-n'-nitro-N-nitrosoguanidine. Cancer research 20031201
Differential expression of genes related to levels of mucosal cell proliferation among multiple rat strains by using oligonucleotide microarrays. Mammalian genome : official journal of the International Mammalian Genome Society 20031201
MNNG induces dramatic DNA damage and non-apoptotic changes in cervical carcinoma HeLa cells. Annals of the New York Academy of Sciences 20031201
Polyozellus multiplex, a Korean wild mushroom, as a potent chemopreventive agent against stomach cancer. Life sciences 20031107
Chromosomally encoded gyrase inhibitor GyrI protects Escherichia coli against DNA-damaging agents. Archives of microbiology 20031101
Apoptosis induced by MNNG in human TK6 lymphoblastoid cells is p53 and Fas/CD95/Apo-1 related. Mutation research 20031101
Poly ADP-ribose polymerase (PARP) inhibitors transiently protect leukemia cells from alkylating agent induced cell death by three different effects. European journal of medical research 20031022
Base excision repair intermediates induce p53-independent cytotoxic and genotoxic responses. The Journal of biological chemistry 20031010
Human proliferating cell nuclear antigen, poly(ADP-ribose) polymerase-1, and p21waf1/cip1. A dynamic exchange of partners. The Journal of biological chemistry 20031010
A single amino acid substitution in MSH5 results in DNA alkylation tolerance. Gene 20031002
N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced in vivo clastogenicity: protective effects of aqueous neem leaf extract. Die Pharmazie 20031001
[Proteomic analysis of cellular responses to low concentration of N-methyl-N'-nitro-N-nitrosoguanidine in human amnion FL cells]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20031001
[Activation of nucleus-independent signals triggered by N-methyl-N'-nitro-N- nitrosoguanidine]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20031001
[Activation of transcription factors induced by low concentration of N-methyl-N'-nitro-N-nitrosoguanidine]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20031001
[Cloning and bioinformatics of human REV3 gene promoter region and its response to carcinogen N-methyl-N'-nitro-N-nitrosoguanidine]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20031001
[Establishment of a cell line with antisense-blocked POLH and the role of POLH in alkylating agent MNNG induced nontargeted mutagenesis]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20031001
Involvement of ATM/ATR-p38 MAPK cascade in MNNG induced G1-S arrest. World journal of gastroenterology 20030915
The mutational spectrum of the HPRT gene from human T cells in vivo shares a significant concordant set of hot spots with MNNG-treated human cells. Cancer research 20030915
NAD+ repletion prevents PARP-1-induced glycolytic blockade and cell death in cultured mouse astrocytes. Biochemical and biophysical research communications 20030905
Enhancement by interleukin-1 beta of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats: a possible mechanism for Helicobacter pylori-associated gastric carcinogenesis. Cancer letters 20030820
Non-apoptogenic killing of hela cervical carcinoma cells after short exposure to the alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Journal of cellular biochemistry 20030815
Activation of protein kinase A and clustering of cell surface receptors by N-methyl-N'-nitro-N-nitrosoguanidine are independent of genomic DNA damage. Mutation research 20030725
UV filters with antagonistic action at androgen receptors in the MDA-kb2 cell transcriptional-activation assay. Toxicological sciences : an official journal of the Society of Toxicology 20030701
Chemoprotective effects of ethanolic extract of neem leaf against MNNG-induced oxidative stress. Die Pharmazie 20030701
Enhancement of carcinogen-induced malignant cell transformation by prostaglandin F(2 alpha). Toxicology 20030630
Response of human REV3 gene to gastric cancer inducing carcinogen N-methyl-N'-nitro-N-nitrosoguanidine and its role in mutagenesis. World journal of gastroenterology 20030515
Methylation-induced G(2)/M arrest requires a full complement of the mismatch repair protein hMLH1. The EMBO journal 20030501
Global expression analysis of N-methyl-N'-nitro-N-nitrosoguanidine-induced rat stomach carcinomas using oligonucleotide microarrays. Carcinogenesis 20030501
Antimutagenic activity of 8-hydroxyisoflavones and 6-hydroxydaidzein from soybean miso. Bioscience, biotechnology, and biochemistry 20030401
Fusion oncogenic tyrosine kinases alter DNA damage and repair after genotoxic treatment: role in drug resistance? Leukemia research 20030301
Suppression by iron chelator phenanthroline of sodium chloride-enhanced gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats. Cancer letters 20030227
Myenteric denervation reduces the incidence of gastric tumors in rats. Cancer letters 20030210
p16 hypermethylation during gastric carcinogenesis of Wistar rats by N-methyl-N'-nitro-N-nitrosoguanidine. Mutation research 20030205
Isolation and characterization of an avirulent Candida albicans yeast monomorphic mutant. Medical mycology 20030201
Molecular and cellular influences of butylated hydroxyanisole on Chinese hamster V79 cells treated with N-methyl-N'-nitro-N-nitrosoguanidine: antimutagenicity of butylated hydroxyanisole. Environmental and molecular mutagenesis 20030101
Antiperoxidative, anti-inflammatory, and antimutagenic activities of ethanol extract of the mycelium of Ganoderma lucidum occurring in South India. Teratogenesis, carcinogenesis, and mutagenesis 20030101
Antimutagenic effects of doenjang (Korean fermented soypaste) and its active compounds. Mutation research 20030101
DNA polymerase beta gene expression: the promoter activator CREB-1 is upregulated in Chinese hamster ovary cells by DNA alkylating agent-induced stress. Biological chemistry 20030101
Effect of volume of culture medium on enhanced citric acid productivity by a mutant culture of Aspergillus niger in stirred fermentor. Letters in applied microbiology 20030101
Isolation and characterisation of phycobiliprotein rich mutant of cyanobacterium Synechocystis sp. Acta biologica Hungarica 20030101
Competition among Bradyrhizobium strains for nodulation of green gram (Vigna radiata): use of dark-nodule strain. Folia microbiologica 20030101
Characterization of Candida albicans colony-morphology mutants and their hybrids. Folia microbiologica 20030101
Altered expression of zinc finger proteins, ADAMs, and integrin-related proteins following treatment of cultured human cells with a low concentration of N-methyl-N'-nitro-N-nitrosoguanidine. Environmental and molecular mutagenesis 20030101
Genomic instability in drug-resistant human melanoma cell lines detected by Alu-I-arbitrary-primed PCR. Anticancer research 20030101
Acclimation and repair of DNA damage in recombinant bioluminescent Escherichia coli. Journal of applied microbiology 20030101
Ethanolic neem leaf extract protects against N-methyl -N'-nitro-N-nitrosoguanidine-induced gastric carcinogenesis in Wistar rats. Asian Pacific journal of cancer prevention : APJCP 20030101
Genetic determination of ploidy level in Xanthophyllomyces dendrorhous. Antonie van Leeuwenhoek 20030101
Abnormal expression of gastric mucin in human and rat aberrant crypt foci during colon carcinogenesis. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20030101
Influence of milk on the antimutagenic potential of green and black teas. Anticancer research 20030101
Effect of S-allylcysteine on oxidant-antioxidant status during N-methyl-N'-nitro-N-nitrosoguanidine and saturated sodium chloride-induced gastric carcinogenesis in Wistar rats. Asia Pacific journal of clinical nutrition 20030101
Reduction of genotoxic effects of the carcinogen N-methyl-N'-nitro-N-nitrosoguanidine by dietary lignin in mammalian cells cultured in vitro. Nutrition and cancer 20030101
Antiperoxidative effects of lycopene during N-methyl-N'-nitro-N-nitrosoguanidine-induced gastric carcinogenesis. Fitoterapia 20021201
Characterization of gene expression changes associated with MNNG, arsenic, or metal mixture treatment in human keratinocytes: application of cDNA microarray technology. Environmental health perspectives 20021201
Physiological alterations and regulation of heterocyst and nitrogenase formation in Het(-) Fix(-) mutant strain of Anabaena variabilis. Current microbiology 20021101
Mutations in tetranucleotide repeats following DNA damage depend on repeat sequence and carcinogenic agent. Cancer research 20021101
Triple therapy with octreotide, galanin and serotonin induces necrosis and increases apoptosis of a rat colon carcinoma. Regulatory peptides 20021015
ATM is activated in response to N-methyl-N'-nitro-N-nitrosoguanidine-induced DNA alkylation. The Journal of biological chemistry 20021011
Enhanced production of itaconic acid from corn starch and market refuse fruits by genetically manipulated Aspergillus terreus SKR10. Bioresource technology 20021001
Different genetic alterations in rat forestomach tumors induced by genotoxic and non-genotoxic carcinogens. Carcinogenesis 20021001
Gastric mucosa lesions induced by duodenogastric reflux increase penetration of N-[3H]-methyl-N-nitro-N-nitrosoguanidine into corpus mucosa of rats. Digestive diseases and sciences 20021001
Serum trace elements status of rabbits supplemented with Nigella sativa, vitamins C and E, and selenium against damage by N-methyl-N'-nitro-N-nitrosoguanidine. Biological trace element research 20021001
Targeted disruption of Np95 gene renders murine embryonic stem cells hypersensitive to DNA damaging agents and DNA replication blocks. The Journal of biological chemistry 20020913
Promotion, but not progression, effects of tamoxifen on uterine carcinogenesis in mice initiated with N-ethyl-N'-nitro-N-nitrosoguanidine. Carcinogenesis 20020901
Appearance of osteonectin-expressing fibroblastic cells in early rat stomach carcinogenesis and stomach tumors induced with N-methyl-N'-nitro-N-nitrosoguanidine. Japanese journal of cancer research : Gann 20020901
Effects of weaning by surrogate mothers (ACI) on tumor development in SD rats treated with methylnitrosourea (MNU) and/or N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Hiroshima journal of medical sciences 20020901
Effects of N-methyl-N'-nitro-N-nitrosoguanidine on the human colorectal polyps consecutively maintained in SCID mice. Cancer letters 20020828
Cadmium affects genes involved in growth regulation during two-stage transformation of Balb/3T3 cells. Toxicology 20020815
Effects of vitamins C and E on cytotoxicity induced by N-nitroso compounds, N-nitrosomorpholine and N-methyl-N'-nitro-N-nitrosoguanidine in Caco-2 and V79 cell lines. Cancer letters 20020808
Pseudouridine, an antimutagenic substance in beer towards N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20020801
Cytoprotective features of selenazofurin in hematopoietic cells. International journal of clinical pharmacology and therapeutics 20020801
Dendritic cell appearance and differentiation during early and late stages of rat stomach carcinogenesis. Japanese journal of cancer research : Gann 20020801
Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science (New York, N.Y.) 20020712
Characterization of Trp(+) reversions in Escherichia coli strain WP2uvrA. Mutagenesis 20020701
Cyclooxygenase-2 and Bcl-2 expression in the stomach mucosa of Wistar rats exposed to Helicobacter pylori, N'-methyl- N'-nitro- N-nitrosoguanidine and bile. Virchows Archiv : an international journal of pathology 20020701
Tricarboxylic acid cycle substrates prevent PARP-mediated death of neurons and astrocytes. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20020701
Strain improvement studies for cephalosporin C production by Cephalosporium acremonium. Die Pharmazie 20020701
Mutant pso8-1 of Saccharomyces cerevisiae, sensitive to photoactivated psoralens, UV radiation, and chemical mutagens, contains a rad6 missense mutant allele. Current genetics 20020701
A mouse kidney cell line with a G:C --> C:G transversion mutator phenotype. Mutation research 20020619
Construction and intergeneric conjugative transfer of a pSG5-based cosmid vector from Escherichia coli to the polyisoprene rubber degrading strain Micromonospora aurantiaca W2b. FEMS microbiology letters 20020604
Profiling and selection of genes differentially expressed in the pylorus of rat strains with different proliferative responses and stomach cancer susceptibility. Carcinogenesis 20020601
Establishment of cisplatin-resistant variants of human neuroblastoma cell lines, TGW and GOTO, and their drug cross-resistance profiles. Cancer chemotherapy and pharmacology 20020601
Antimutagenic effect of amino acids on the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Bioscience, biotechnology, and biochemistry 20020601
Production of hydroxyl free radical in the xanthine oxidase system with addition of 1-methyl-3-nitro-1-nitrosoguanidine. Free radical research 20020601
Independent variation in susceptibilities of six different mouse strains to induction of pepsinogen-altered pyloric glands and gastric tumor intestinalization by N-methyl-N-nitrosourea. Cancer letters 20020528
Duodenogastric reflux increases the penetration of N-3H-methyl-N-nitro-N-nitrosoguanidine into the antral mucosa of rats: a possible role for mucosal erosions and increased cell proliferation in gastric carcinogenesis. Japanese journal of cancer research : Gann 20020501
Methylation tolerance in mismatch repair proficient cells with low MSH2 protein level. Oncogene 20020425
Expression site activation in Trypanosoma brucei with three marked variant surface glycoprotein gene expression sites. Molecular and biochemical parasitology 20020409
Promoting effects of combined antioxidant and sodium nitrite treatment on forestomach carcinogenesis in rats after initiation with N-methyl-N'-nitro-N-nitrosoguanidine. Cancer letters 20020408
Rapid cell death in Xanthomonas campestris pv. glycines. The Journal of general and applied microbiology 20020401
Ethanol-enhanced cytotoxicity of alkylating agents. Alcoholism, clinical and experimental research 20020301
Low expression of cyclin D2 in G2/M-arrested and transformed proliferating Balb/3T3 cells. The Journal of veterinary medical science 20020301
Uterine adenocarcinoma in N-ethyl-N'-nitro-N-nitrosoguanidine-treated rats with high-dose exposure to p-tert-octylphenol during adulthood. Japanese journal of cancer research : Gann 20020201
Prevention of N-methyl-N'-nitro-N-nitrosoguanidine and saturated sodium chloride-induced gastric carcinogenesis in Wistar rats by lycopene. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 20020201
Further evaluation of an in vivo micronucleus test on rat and mouse skin: results with five skin carcinogens. Mutation research 20020115
Green fluorescent protein-based biosensor for detecting SOS-inducing activity of genotoxic compounds. Journal of microbiological methods 20020101
Interventional study of high dose folic acid in gastric carcinogenesis in beagles. Gut 20020101
Vitamin C and quercetin modulate DNA-damaging effect of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Plant foods for human nutrition (Dordrecht, Netherlands) 20020101
Inhibition by long-term fermented miso of induction of gastric tumors by N-methyl-N'-nitro-N-nitrosoguanidine in CD (SD) rats. Oncology reports 20020101
Isolation and characterization of mutants of two diazotrophic cyanobacteria tolerant to high concentrations of inorganic carbon. Microbiological research 20020101
Heterogeneity in expression of DNA polymerase beta and DNA repair activity in human tumor cell lines. Gene expression 20020101
Anti-mutagenic activity of Phyllanthus amarus Schum & Thonn in vitro as well as in vivo. Teratogenesis, carcinogenesis, and mutagenesis 20020101
[The increasing mutagenic effect of nitrosoguanidine under the influence of modified bases during inhibition of repair AGT enzyme in mammalian somatic cells in vitro]. TSitologiia i genetika 20020101
Implantation of MNNG crystals into a Triturus intact limb affects mitotic and labeling indices, regeneration rate, and morphogenesis in the contralateral, regenerating limb. Teratogenesis, carcinogenesis, and mutagenesis 20020101
[Effect of MNNG on ornithine decarboxylase activity in cells from adult Schistosoma japonicum]. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 20020101
N-Methyl-N'-nitro-N-nitrosoguanidine. Report on carcinogens : carcinogen profiles 20020101
Spontaneous and MNNG-induced reversion of an EGFP construct in HeLa cells: an assay for observing mutations in living cells by fluorescent microscopy. Human mutation 20011201
[Selection of beta-glucanase-producing Trichoderma köningii T199 and its fermentation conditions]. Wei sheng wu xue bao = Acta microbiologica Sinica 20011201
Attenuation of catalase activity in the malignant phenotype plays a functional role in an in vitro model for tumor progression. Cancer letters 20011128
Helicobacter pylori, N-methyl-N'-nitro-N'-nitrosoguanidine, and bile modulate gastric cell kinetics in experimental cancer. Virchows Archiv : an international journal of pathology 20011101
Effects of Helicobacter pylori and bile on N-methyl-N'-nitro-N'-nitrosoguanidine exposed antral mucosa of C57BU6 mice. Virchows Archiv : an international journal of pathology 20011101
Mutagenesis of the rapamycin producer Streptomyces hygroscopicus FC904. The Journal of antibiotics 20011101
Contribution of apoptosis to responses in the comet assay. Mutation research 20011018
Roles of DNA fragmentation factor and poly(ADP-ribose) polymerase in an amplification phase of tumor necrosis factor-induced apoptosis. The Journal of biological chemistry 20011012
p53 Phosphorylation at serine 15 is required for transcriptional induction of the plasminogen activator inhibitor-1 (PAI-1) gene by the alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine. The Journal of biological chemistry 20010928
Partial chemical/structural elucidation of anti-mutagenic compounds from corn. Toxicology 20010925
N-nitrososdimethylamine is activated in microsomes from hepatocytes to reactive metabolites which damage DNA of non-parenchymal cells in rat liver. Toxicology letters 20010915
Suppressive effect of irsogladine maleate on N-methyl-N-nitro-N-nitrosoguanidine (MNNG)-initiated and glyoxal-promoted gastric carcinogenesis in rats. Toxicology 20010914
Quantification of changes in c-myc mRNA levels in normal human bronchial epithelial (NHBE) and lung adenocarcinoma (A549) cells following chemical treatment. Toxicological sciences : an official journal of the Society of Toxicology 20010901
DNA damage-induced cell cycle checkpoints involve both p53-dependent and -independent pathways: role of telomere repeat binding factor 2. British journal of cancer 20010901
Abbreviated cell cycle progression induced by the serine/threonine protein phosphatase inhibitor okadaic acid at concentrations that promote neoplastic transformation. Carcinogenesis 20010801
Effect of selenomethionine on N-methylnitronitrosoguanidine-induced colonic aberrant crypt foci in rats. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 20010801
Attenuation by ambroxol of monochloramine-enhanced gastric carcinogenesis: a possible prevention against Helicobacter pylori-associated gastric carcinogenesis. Cancer letters 20010726
Activation of a p53-independent, sphingolipid-mediated cytolytic pathway in p53-negative mouse fibroblast cells treated with N-methyl-N-nitro-N-nitrosoguanidine. The Journal of biological chemistry 20010720
Low concentration N-methyl-N'-nitro-N-nitrosoguanidine activates DNA polymerase-beta expression via cyclic-AMP-protein kinase A-cAMP response element binding protein pathway. Mutation research 20010701
Cell cycle was disturbed in the MNNG-induced initiation stage during in vitro two-stage transformation of Balb/3T3 cells. Toxicology 20010621
Transretinoic acid inhibits rats gastric epithelial dysplasia induced by N-methyl-N-nitro-N-nitrosoguanidine: influences on cell apoptosis and expression of its regulatory genes. World journal of gastroenterology 20010615
Msh-2 suppresses in vivo mutation in a gene dose and lesion dependent manner. Oncogene 20010614
Transcription factor Yin Yang 1 stimulates poly(ADP-ribosyl)ation and DNA repair. Biochemical and biophysical research communications 20010608
Impaired repair activity of a truncated DNA polymerase beta protein. Life sciences 20010608
Improvement of in vitro two-stage transformation assay and determination of the promotional effect of cadmium. Toxicology in vitro : an international journal published in association with BIBRA 20010601
Sequential histopathological changes in vivo after suicide gene therapy of gastric cancer induced by N-methyl-N'-nitro-N-nitrosoguanidine in rats. Japanese journal of cancer research : Gann 20010601
Anti-genotoxicity of trans-anethole and eugenol in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20010501
Influence of metallothionein-1 localization on its function. The Biochemical journal 20010415
Effect of mild whole body hyperthermia on cytotoxic action of N-methyl-N'-nitro-N-nitrosoguanidine in Swiss mice. Toxicology letters 20010408
Non-invasive approach for diagnosing atrophic gastritis using the 13C-bicarbonate breath test. International journal of molecular medicine 20010401
Fumonisin B1 promotes aflatoxin B1 and N-methyl-N'-nitro-nitrosoguanidine-initiated liver tumors in rainbow trout. Toxicology and applied pharmacology 20010401
Cadmium-induced alterations of connexin expression in the promotion stage of in vitro two-stage transformation. Toxicology 20010321
Quantification of tumor cell injury in vitro and in vivo using expression of green fluorescent protein under the control of the GADD153 promoter. International journal of cancer 20010215
[The role of Helicobacter pylori infection and effect of eradication in experimental animal models of gastric carcinogenesis]. Nihon rinsho. Japanese journal of clinical medicine 20010201
Isolation and characterization of the Enterobacter cloacae cheR mutant defective in phosphate taxis. Bioscience, biotechnology, and biochemistry 20010201
Antimutagenic activity of isoflavone from Pueraria lobata. Journal of agricultural and food chemistry 20010101
Highly elevated ultraviolet-induced mutation frequency in isolated Chinese hamster cell lines defective in nucleotide excision repair and mismatch repair proteins. Cancer research 20010101
Topoisomerase I-mediated cytotoxicity of N-methyl-N'-nitro-N-nitrosoguanidine: trapping of topoisomerase I by the O6-methylguanine. Cancer research 20010101
Differences in carcinogenesis by the length of carcinogen exposure period in rat colon. Digestive diseases and sciences 20010101
Genotoxicity of di-butyl-phthalate and di-iso-butyl-phthalate in human lymphocytes and mucosal cells. Teratogenesis, carcinogenesis, and mutagenesis 20010101
Genotoxicity of nitroso compounds and sodium dichromate in a model combining organ cultures of human nasal epithelia and the comet assay. ORL; journal for oto-rhino-laryngology and its related specialties 20010101
[Characteristics of mutants of Streptomyces peucetius subsp. caesius ATCC 27952 resistant to anthracycline antibiotics]. Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993) 20010101
Induction by bombesin of peritoneal metastasis of gastric cancers induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats. Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 20010101
Protection of N-methyl-N'-nitro-N-nitrosoguanidine-induced in vivo clastogenicity by aqueous garlic extract. Asia Pacific journal of clinical nutrition 20010101
Increased pathology incidence in the forestomach of rats maintained on a diet containing ivermectin and given a single dose of N-methyl-N1-nitro-N-nitrosoguanidine. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20010101
Chemopreventive effects of curcumin on glandular stomach carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine and sodium chloride in rats. Anticancer research 20010101

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