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2943-56-8 | 2,4(1H,3H)-Pyrimidinedione, dihydro-5,6-dihydroxy-5-methyl-
CAS No: 2943-56-8 Catalog No: AG002YDD MDL No:
Product Description
Catalog Number:
AG002YDD
Chemical Name:
2,4(1H,3H)-Pyrimidinedione, dihydro-5,6-dihydroxy-5-methyl-
CAS Number:
2943-56-8
Molecular Formula:
C5H8N2O4
Molecular Weight:
160.1280
IUPAC Name:
5,6-dihydroxy-5-methyl-1,3-diazinane-2,4-dione
InChI:
InChI=1S/C5H8N2O4/c1-5(11)2(8)6-4(10)7-3(5)9/h2,8,11H,1H3,(H2,6,7,9,10)
InChI Key:
GUKSGXOLJNWRLZ-UHFFFAOYSA-N
SMILES:
O=C1NC(O)C(C(=O)N1)(C)O
Properties
Complexity:
217
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
160.048g/mol
Formal Charge:
0
Heavy Atom Count:
11
Hydrogen Bond Acceptor Count:
4
Hydrogen Bond Donor Count:
4
Isotope Atom Count:
0
Molecular Weight:
160.129g/mol
Monoisotopic Mass:
160.048g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
98.7A^2
Undefined Atom Stereocenter Count:
2
Undefined Bond Stereocenter Count:
0
XLogP3:
-2
Literature
| Title | Journal |
|---|---|
| Profiling cytosine oxidation in DNA by LC-MS/MS. | Chemical research in toxicology 20120917 |
| Structural characterization of viral ortholog of human DNA glycosylase NEIL1 bound to thymine glycol or 5-hydroxyuracil-containing DNA. | The Journal of biological chemistry 20120203 |
| Structural and functional properties of CiNTH, an endonuclease III homologue of the ascidian Ciona intestinalis: critical role of N-terminal region. | Genes & genetic systems 20120101 |
| A crystallographic study of the role of sequence context in thymine glycol bypass by a replicative DNA polymerase serendipitously sheds light on the exonuclease complex. | Journal of molecular biology 20110909 |
| Lesion bypass activity of DNA polymerase θ (POLQ) is an intrinsic property of the pol domain and depends on unique sequence inserts. | Journal of molecular biology 20110121 |
| New insights in the removal of the hydantoins, oxidation product of pyrimidines, via the base excision and nucleotide incision repair pathways. | PloS one 20110101 |
| A nuclear family A DNA polymerase from Entamoeba histolytica bypasses thymine glycol. | PLoS neglected tropical diseases 20100801 |
| DNA polymerases beta and lambda bypass thymine glycol in gapped DNA structures. | Biochemistry 20100608 |
| Products of thymine oxygenation by a non-heme oxygenation model, Fe(II)(MeCN)6(2+)-Ac2O-H2O2, and the transition state model between oxoiron and thymine. | Chemical & pharmaceutical bulletin 20100601 |
| Efficient formation of the tandem thymine glycol/8-oxo-7,8-dihydroguanine lesion in isolated DNA and the mutagenic and cytotoxic properties of the tandem lesions in Escherichia coli cells. | Chemical research in toxicology 20100118 |
| DNA-Destabilizing Agents as an Alternative Approach for Targeting DNA: Mechanisms of Action and Cellular Consequences. | Journal of nucleic acids 20100101 |
| The cis-(5R,6S)-thymine glycol lesion occupies the wobble position when mismatched with deoxyguanosine in DNA. | Biochemistry 20091020 |
| Altered expression of the human base excision repair gene NTH1 in gastric cancer. | Carcinogenesis 20090801 |
| Theoretical studies on the thermodynamics and kinetics of the N-glycosidic bond cleavage in deoxythymidine glycol. | The journal of physical chemistry. B 20090730 |
| FANCJ helicase uniquely senses oxidative base damage in either strand of duplex DNA and is stimulated by replication protein A to unwind the damaged DNA substrate in a strand-specific manner. | The Journal of biological chemistry 20090703 |
| Processing of thymine glycol in a clustered DNA damage site: mutagenic or cytotoxic. | Nucleic acids research 20090701 |
| Interconversion of the cis-5R,6S- and trans-5R,6R-thymine glycol lesions in duplex DNA. | Journal of the American Chemical Society 20080903 |
| A novel monofunctional DNA glycosylase activity against thymine glycol in mouse cell nuclei. | Journal of radiation research 20080501 |
| Cylindrical projection of electrostatic potential and image analysis tools for damaged DNA: the substitution of thymine with thymine glycol. | The journal of physical chemistry. B 20080221 |
| RNA polymerase II bypasses 8-oxoguanine in the presence of transcription elongation factor TFIIS. | DNA repair 20070601 |
| RNA polymerase II bypass of oxidative DNA damage is regulated by transcription elongation factors. | The EMBO journal 20061129 |
| Photoinduced reductive repair of thymine glycol: implications for excess electron transfer through DNA containing modified bases. | Journal of the American Chemical Society 20060823 |
| Human DNA polymerase N (POLN) is a low fidelity enzyme capable of error-free bypass of 5S-thymine glycol. | The Journal of biological chemistry 20060818 |
| Repair of thymine glycol by hNth1 and hNeil1 is modulated by base pairing and cis-trans epimerization. | DNA repair 20060408 |
| A novel approach to DNA damage assessments: measurement of the thymine glycol lesion. | Radiation research 20060401 |
| Singlet oxygen-induced DNA damage. | Radiation research 20060401 |
| Base excision repair by hNTH1 and hOGG1: a two edged sword in the processing of DNA damage in gamma-irradiated human cells. | DNA repair 20060105 |
| Host cell reactivation of plasmids containing oxidative DNA lesions is defective in Cockayne syndrome but normal in UV-sensitive syndrome fibroblasts. | DNA repair 20060105 |
| Characterization of the binding of distamycin A to damaged DNA: a comparison with the DNA recognition of the human DDB protein. | Nucleic acids symposium series (2004) 20060101 |
| DNA glycosylase activities for thymine residues oxidized in the methyl group are functions of the hNEIL1 and hNTH1 enzymes in human cells. | DNA repair 20050102 |
| High-efficiency bypass of DNA damage by human DNA polymerase Q. | The EMBO journal 20041110 |
| Independent generation of the 5-hydroxy-5,6-dihydrothymidin-6-yl radical and its reactivity in dinucleoside monophosphates. | Journal of the American Chemical Society 20041020 |
| The role of active arsenic species produced by metabolic reduction of dimethylarsinic acid in genotoxicity and tumorigenesis. | Toxicology and applied pharmacology 20040801 |
| Single-stranded breaks in DNA but not oxidative DNA base damages block transcriptional elongation by RNA polymerase II in HeLa cell nuclear extracts. | The Journal of biological chemistry 20040430 |
| Stereoselective excision of thymine glycol lesions by mammalian cell extracts. | DNA repair 20040304 |
| Damage specificity of human DNA glycosylases for oxidative pyrimidine lesions. | Nucleic acids symposium series (2004) 20040101 |
| Cellular and molecular mechanisms in environmental and occupational inhalation toxicology. | GMS current topics in otorhinolaryngology, head and neck surgery 20040101 |
| Oxidative DNA damage following exposure to dimethylarsinous iodide: the formation of cis-thymine glycol. | Toxicology letters 20030720 |
| Endonuclease IV enhances base excision repair of endonuclease III from Methanobacterium thermoautotrophicum. | DNA repair 20030513 |
| Mode of inhibition of short-patch base excision repair by thymine glycol within clustered DNA lesions. | The Journal of biological chemistry 20030314 |
| Yeast DNA polymerase zeta (zeta) is essential for error-free replication past thymine glycol. | Genes & development 20030101 |
| Human DNA polymerase kappa bypasses and extends beyond thymine glycols during translesion synthesis in vitro, preferentially incorporating correct nucleotides. | The Journal of biological chemistry 20021004 |
| Depleted uranium-catalyzed oxidative DNA damage: absence of significant alpha particle decay. | Journal of inorganic biochemistry 20020725 |
| Novel nuclear and mitochondrial glycosylases revealed by disruption of the mouse Nth1 gene encoding an endonuclease III homolog for repair of thymine glycols. | The EMBO journal 20020701 |
| Translesion synthesis by human DNA polymerase eta across thymine glycol lesions. | Biochemistry 20020514 |
| HPLC isolation and mass spectrometric characterization of two isomers of thymine glycols in oligodeoxynucleotides. | Chemical research in toxicology 20020501 |
| Determination of active site residues in Escherichia coli endonuclease VIII. | The Journal of biological chemistry 20020125 |
| Effect of thymine glycol on transcription elongation by T7 RNA polymerase and mammalian RNA polymerase II. | The Journal of biological chemistry 20011130 |
| Synthesis and thermodynamic studies of oligonucleotides containing the two isomers of thymine glycol. | Chemistry (Weinheim an der Bergstrasse, Germany) 20011015 |
| [Oxidative DNA damage]. | Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20010601 |
| [Repair networks for base damage and single-strand breaks]. | Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20010601 |
| Factors influencing the removal of thymine glycol from DNA in gamma-irradiated human cells. | Progress in nucleic acid research and molecular biology 20010101 |
| Thymine DNA glycosylase. | Progress in nucleic acid research and molecular biology 20010101 |
| Base excision repair in nuclear and mitochondrial DNA. | Progress in nucleic acid research and molecular biology 20010101 |
| Properties and functions of human uracil-DNA glycosylase from the UNG gene. | Progress in nucleic acid research and molecular biology 20010101 |
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