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CAS No: 291-70-3 Catalog No: AG002XC4 MDL No:
Title | Journal |
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Ocular hypotensive effect of the novel EP3/FP agonist ONO-9054 versus Xalatan: results of a 28-day, double-masked, randomised study. | The British journal of ophthalmology 20170601 |
Novel Pharmacologic Candidates for Treatment of Primary Open-Angle Glaucoma. | The Yale journal of biology and medicine 20170301 |
Ocular Hypotensive Effect of ONO-9054, an EP3/FP Receptor Agonist: Results of a Randomized, Placebo-controlled, Dose Escalation Study. | Journal of glaucoma 20161001 |
3-Methyl-4,5-dihydro-oxepine, polyoxygenated seco-cyclohexenes and cyclohexenes from Uvaria flexuosa and their anti-inflammatory activity. | Phytochemistry 20160201 |
Efficacy of monepantel, derquantel and abamectin against adult stages of a multi-resistant Haemonchus contortus isolate. | Parasitology research 20121101 |
The efficacy of a combined oral formulation of derquantel-abamectin against anthelmintic resistant gastro-intestinal nematodes of sheep in the UK. | Veterinary parasitology 20121026 |
The comparative efficacy of abamectin, monepantel and an abamectin/derquantel combination against fourth-stage larvae of a macrocyclic lactone-resistant Teladorsagia spp. isolate infecting sheep. | Veterinary parasitology 20120813 |
Modelling the benefits of a new class of anthelmintic in combination. | Veterinary parasitology 20120504 |
Depsidones, aromatase inhibitors and radical scavenging agents from the marine-derived fungus Aspergillus unguis CRI282-03. | Planta medica 20120401 |
Total synthesis of an oxepine natural product, (±)-janoxepin. | Organic letters 20120217 |
Enantioselective total synthesis of (-)-acetylaranotin, a dihydrooxepine epidithiodiketopiperazine. | Journal of the American Chemical Society 20120201 |
Investigating the role of melanin in UVA/UVB- and hydrogen peroxide-induced cellular and mitochondrial ROS production and mitochondrial DNA damage in human melanoma cells. | Free radical biology & medicine 20120201 |
Structure-activity relationship for the first-in-class clinical steroid sulfatase inhibitor Irosustat (STX64, BN83495). | ChemMedChem 20111104 |
Posttraining ablation of adult-generated neurons degrades previously acquired memories. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20111019 |
Apoptosis inhibitors and mini-agrin have additive benefits in congenital muscular dystrophy mice. | EMBO molecular medicine 20110801 |
Total synthesis of (+)-(2'S,3'R)-zoapatanol exploiting the B-alkyl Suzuki reaction and the nucleophilic potential of the sulfinyl group. | Chemistry (Weinheim an der Bergstrasse, Germany) 20110718 |
KLF4 promotes the odontoblastic differentiation of human dental pulp cells. | Journal of endodontics 20110701 |
Block of glucocorticoid synthesis during re-activation inhibits extinction of an established fear memory. | Neurobiology of learning and memory 20110501 |
rac-12,14-Dicyclo-propyl-5,8,13,18,21-penta-oxapenta-cyclo-[13.8.0.0.0.0]tricosa-1(15),2(11),3,9(10),16,22(23)-hexa-ene. | Acta crystallographica. Section E, Structure reports online 20110501 |
Antiparasitic compounds from Cupania cinerea with activities against Plasmodium falciparum and Trypanosoma brucei rhodesiense. | Journal of natural products 20110425 |
Studies on the mechanism of ring hydrolysis in phenylacetate degradation: a metabolic branching point. | The Journal of biological chemistry 20110401 |
3-(2,4-Difluoro-anilino)-9-nitro-dibenzo[b,e]oxepin-11(6H)-one. | Acta crystallographica. Section E, Structure reports online 20110301 |
3-(2,4-Dimeth-oxy-anilino)-8-meth-oxy-dibenz[b,e]oxepin-11(6H)-one. | Acta crystallographica. Section E, Structure reports online 20110201 |
cis-6-Bromo-4-(1-methyl-1H-indol-3-yl)-10,10a-dihydro-1H,4H-2,9-dioxa-3-aza-benz[f]azulene. | Acta crystallographica. Section E, Structure reports online 20110201 |
Psammaplysin H, a new antimalarial bromotyrosine alkaloid from a marine sponge of the genus Pseudoceratina. | Bioorganic & medicinal chemistry letters 20110115 |
Apoptosis-inducing effect of diketopiperazine disulfides produced by Aspergillus sp. KMD 901 isolated from marine sediment on HCT116 colon cancer cell lines. | Journal of applied microbiology 20110101 |
New stress metabolite from Bulbophyllum kwangtungense. | Natural product communications 20110101 |
Antibacterial activity of new dibenzoxepinone oximes with fluorine and trifluoromethyl group substituents. | International journal of molecular sciences 20110101 |
Synthesis and Antimicrobial Evaluation of Dibenzo[b,e]oxepin-11(6H)-one O-Benzoyloxime Derivatives. | Scientia pharmaceutica 20110101 |
Metal-catalyzed cycloetherification reactions of β,γ- and γ,δ-allendiols: chemo-, regio-, and stereocontrol in the synthesis of oxacycles. | Chemistry (Weinheim an der Bergstrasse, Germany) 20101122 |
Resilience to social stress coincides with functional DNA methylation of the Crf gene in adult mice. | Nature neuroscience 20101101 |
HPLC isolation of antioxidant constituents from Xanthoparmelia spp. | Journal of pharmaceutical and biomedical analysis 20101010 |
Insights into the formation and isomerization of the benzene metabolite muconaldehyde and related molecules: comparison of computational and experimental studies of simple, benzo-annelated, and bridged 2,3-epoxyoxepins. | The Journal of organic chemistry 20100716 |
The anti-inflammatory and neuroprotective effects of ghrelin in subarachnoid hemorrhage-induced oxidative brain damage in rats. | Journal of neurotrauma 20100601 |
Design, synthesis and SAR of phenylamino-substituted 5,11-dihydro-dibenzo[a,d]cyclohepten-10-ones and 11H-dibenzo[b,f]oxepin-10-ones as p38 MAP kinase inhibitors. | Bioorganic & medicinal chemistry letters 20100515 |
The effect of amygdala kindling on hippocampal neurogenesis coincides with decreased reelin and DISC1 expression in the adult dentate gyrus. | Hippocampus 20100501 |
The fate of benzene-oxide. | Chemico-biological interactions 20100319 |
Modeling the formation and reactions of benzene metabolites. | Chemico-biological interactions 20100319 |
Serum MMP-7 is increased in diabetic renal disease and diabetic diastolic dysfunction. | Diabetes research and clinical practice 20100301 |
Keap1-Nrf2 activation in the presence and absence of DJ-1. | The European journal of neuroscience 20100301 |
Exploring epidermal growth factor receptor (EGFR) inhibitor features: the role of fused dioxygenated rings on the quinazoline scaffold. | Journal of medicinal chemistry 20100225 |
Synthesis of oxepines and 2-branched pyranosides from a d-glucal-derived gem-dibromo-1,2-cyclopropanated sugar. | The Journal of organic chemistry 20100205 |
Active sites in graphene and the mechanism of CO2 formation in carbon oxidation. | Journal of the American Chemical Society 20091202 |
Omigapil ameliorates the pathology of muscle dystrophy caused by laminin-alpha2 deficiency. | The Journal of pharmacology and experimental therapeutics 20091201 |
Xanthones and oxepino[2, 3-b]chromones from three endophytic fungi. | Chemistry (Weinheim an der Bergstrasse, Germany) 20091109 |
Heptanosides from galactose-derived oxepenes via stereoselective addition reactions. | The Journal of organic chemistry 20091016 |
Urinary excretion of low molecular weight proteins in goats during the neonatal period. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20091001 |
The effects of calorie restriction olfactory cues on conspecific anxiety-like behaviour. | Behavioural brain research 20090812 |
Stereoselective synthesis of spirocyclic oxindoles via Prins cyclizations. | Organic letters 20090806 |
Targets for neuroprotection in Parkinson's disease. | Biochimica et biophysica acta 20090701 |
Evidence that humans metabolize benzene via two pathways. | Environmental health perspectives 20090601 |
An oxepinoflavone from Artocarpus elasticus with cytotoxic activity against P-388 cells. | Archives of pharmacal research 20090201 |
Asymmetric synthesis of the ABC-ring system of the antitumor antibiotic MPC1001. | The Journal of organic chemistry 20090116 |
Phenolic compounds with cell protective activity from the fruits of Livistona chinensis. | Journal of Asian natural products research 20090101 |
alpha-glucosidase inhibitors from Garcinia brevipedicellata (Clusiaceae). | Chemical & pharmaceutical bulletin 20081001 |
A density functional theory study of rhodium-catalyzed hetero-[5+2]-cycloaddition of cyclopropyl imine derivatives and alkynes. | The journal of physical chemistry. A 20080925 |
CoMFA, CoMSIA and eigenvalue analysis on dibenzodioxepinone and dibenzodioxocinone derivatives as cholesteryl ester transfer protein inhibitors. | Molecules (Basel, Switzerland) 20080822 |
Stereoselectivity in the epoxidation of carbohydrate-based oxepines. | The Journal of organic chemistry 20080815 |
The effect of early maternal separation on brain derived neurotrophic factor and monoamine levels in adult heterozygous reeler mice. | Progress in neuro-psychopharmacology & biological psychiatry 20080701 |
Structure revision of circumdatins A and B, benzodiazepine alkaloids produced by marine fungus Aspergillus ostianus, by X-ray crystallography. | The Journal of organic chemistry 20080606 |
Enzyme-catalysed synthesis and reactions of benzene oxide/oxepine derivatives of methyl benzoates. | Organic & biomolecular chemistry 20080407 |
Task-dependent and task-independent neurovascular responses to syntactic processing. | Cortex; a journal devoted to the study of the nervous system and behavior 20080301 |
Synthesis of trans-fused tetrahydrooxepins: stereoselective allylation of sulfur or fluoro-substituted tetrahydrooxepins. | Carbohydrate research 20080225 |
A diastereoselective ring contraction of 1,3-dioxepins to 2,3,4-trisubstituted and tetrasubstituted tetrahydrofurans. | The Journal of organic chemistry 20080118 |
An auditory brain-computer interface (BCI). | Journal of neuroscience methods 20080115 |
Diverging Rh(I)-catalyzed carbocylization strategy to prepare a library of unique cyclic ethers. | Journal of combinatorial chemistry 20080101 |
Theoretical study of reaction mechanisms of OH radical with toluene 1,2-epoxide/2-methyloxepin. | The journal of physical chemistry. A 20071220 |
A diastereoselective intermolecular heck reaction of 1,3-dioxepins. | Organic letters 20071122 |
Role of the primate orbitofrontal cortex in mediating anxious temperament. | Biological psychiatry 20071115 |
Adjunctive therapy of uncontrolled partial seizures with levetiracetam in Australian patients. | Epilepsy & behavior : E&B 20071101 |
Calbindin D28K protein cells in a primate suprachiasmatic nucleus: localization, daily rhythm and age-related changes. | The European journal of neuroscience 20071001 |
Phase II/III randomized trial of TCH346 in patients with ALS. | Neurology 20070821 |
Synthesis of substituted septanosyl-1,2,3-triazoles. | Carbohydrate research 20070723 |
Synthesis of dihydrooxepin models related to the antitumor antibiotic MPC1001. | Organic letters 20070719 |
Stictic acid derivatives from the lichen Usnea articulata and their antioxidant activities. | Journal of natural products 20070701 |
Post-translational protein modifications in type 1 diabetes: a role for the repair enzyme protein-L-isoaspartate (D-aspartate) O-methyltransferase? | Diabetologia 20070301 |
1,5-Benzodioxepin derivatives as a novel class of muscarinic M3 receptor antagonists. | Bioorganic & medicinal chemistry letters 20070215 |
New dibenz[b, f]oxepins from Cercis chinensis Bunge. | Journal of Asian natural products research 20070101 |
Synthesis and properties of oligonucleotides containing a 7-membered (oxepane) sugar ring. | Nucleosides, nucleotides & nucleic acids 20070101 |
Design, synthesis, and biological evaluation of phenylamino-substituted 6,11-dihydro-dibenzo[b,e]oxepin-11-ones and dibenzo[a,d]cycloheptan-5-ones: novel p38 MAP kinase inhibitors. | Journal of medicinal chemistry 20061228 |
Synthesis of 1,2,4-trioxepanes via application of thiol-olefin co-oxygenation methodology. | Bioorganic & medicinal chemistry letters 20061201 |
TCH346 as a neuroprotective drug in Parkinson's disease: a double-blind, randomised, controlled trial. | The Lancet. Neurology 20061201 |
Diversity-oriented approach to biologically relevant molecular frameworks starting with beta-naphthol and using the Claisen rearrangement and olefin metathesis as key steps. | Chemistry (Weinheim an der Bergstrasse, Germany) 20061025 |
The loss of carbon dioxide from activated perbenzoate anions in the gas phase: unimolecular rearrangement via epoxidation of the benzene ring. | The Journal of organic chemistry 20061013 |
Investigation of selective mono-deallylation of O,O'-diallylcatechols and 3-methylene-1,5-benzodioxepanes. | Chemical & pharmaceutical bulletin 20060901 |
The role of asynchronous bond formation in the diastereoselective epoxidation of cyclic enol ethers: a density functional theory study. | The Journal of organic chemistry 20060721 |
Rearrangements of the Diels-Alder cycloadducts obtained from acetylenic sulfones and 1,3-diphenylisobenzofuran. | The Journal of organic chemistry 20060707 |
Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine. | Journal of medicinal chemistry 20060406 |
Aromatic constituents of Uvaria grandiflora. | Journal of natural products 20060401 |
High-resolution structure of human D-glyceraldehyde-3-phosphate dehydrogenase. | Acta crystallographica. Section D, Biological crystallography 20060301 |
Antineoplastic agents. 551. Isolation and structures of bauhiniastatins 1-4 from Bauhinia purpurea. | Journal of natural products 20060301 |
The use of LC/MS, GC/MS, and LC/NMR hyphenated techniques to identify a drug degradation product in pharmaceutical development. | Journal of pharmaceutical and biomedical analysis 20060224 |
Boron trifluoride-induced, new stereospecific rearrangements of chiral epoxy ethers. Ready access to enantiopure 4-(diarylmethyl)-1,3-dioxolanes and 4,5-disubstituted tetrahydrobenzo[c]oxepin-4-ols. | The Journal of organic chemistry 20060217 |
Expressions of cytokines and chemokines in the dorsal motor nucleus of the vagus nerve after right vagotomy. | Brain research. Molecular brain research 20051207 |
Anticipating the effects of gravity when intercepting moving objects: differentiating up and down based on nonvisual cues. | Journal of neurophysiology 20051201 |
Conditioned effects of kindling three different sites in the hippocampal complex of the rat. | Behavioral neuroscience 20051201 |
Serotonergic 5-HT2A receptor stimulation induces steroid 5alpha-reductase gene expression in rat C6 glioma cells via transcription factor Egr-1. | Brain research. Molecular brain research 20051003 |
Effects of glutamate transporter and receptor ligands on neuronal glutamate uptake. | Neuroscience research 20050901 |
Neuronal cell loss accompanies the brain tissue response to chronically implanted silicon microelectrode arrays. | Experimental neurology 20050901 |
Syntheses of tetrahydrofurobenzofurans and dihydromethanobenzodioxepines from 5-hydroxy-3-methyl-3H-benzofuran-2-one. Rearrangement and ring expansion under reductive conditions on treatment with hydrides. | The Journal of organic chemistry 20050805 |
The role of prolactin and testosterone in mediating seasonal differences in the self-grooming behavior of male meadow voles, Microtus pennsylvanicus. | Physiology & behavior 20050721 |
Novel 2-N,N-dimethylaminomethyl-2,3,3a,12b-tetrahydrodibenzo[b,f]furo[2,3-d]oxepin derivatives displaying combined norepinephrine reuptake inhibition and 5-HT2A/2C receptor antagonism. | Bioorganic & medicinal chemistry letters 20050602 |
Extinction of cocaine self-administration reveals functionally and temporally distinct dopaminergic signals in the nucleus accumbens. | Neuron 20050519 |
The inhibitory effects of peripheral administration of peptide YY(3-36) and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway. | Brain research 20050517 |
Two novel series of allocolchicinoids with modified seven membered B-rings: design, synthesis, inhibition of tubulin assembly and cytotoxicity. | Bioorganic & medicinal chemistry 20050516 |
Neuronal nitric oxide synthase inhibition differentially affects oxytocin and vasopressin secretion in salt loaded rats. | Neuroscience letters 20050506 |
Pinocchio, a novel protein expressed in the antenna, contributes to olfactory behavior in Drosophila melanogaster. | Journal of neurobiology 20050501 |
Effect of cell-density on in-vitro dopaminergic differentiation of mesencephalic precursor cells. | Neuroreport 20050404 |
Bifunctional compounds eliciting both anti-inflammatory and cholinergic activity as potential drugs for neuroinflammatory impairments. | Neuroscience letters 20050307 |
Endothelial nitric oxide synthase regulates brain-derived neurotrophic factor expression and neurogenesis after stroke in mice. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20050302 |
Early alcohol exposure induces persistent alteration of cortical columnar organization and reduced orientation selectivity in the visual cortex. | Journal of neurophysiology 20050301 |
Striatal inhibition of nociceptive responses evoked in trigeminal sensory neurons by tooth pulp stimulation. | Journal of neurophysiology 20050301 |
Synthesis of 2-N,N-dimethylaminomethyl-2,3,3a,12b-tetrahydrodibenzo[b,f]furo[2,3-d]oxepine derivatives as potential anxiolytic agents. Part 2: substitutions by methyl groups on the tetrahydrofuran ring. | Farmaco (Societa chimica italiana : 1989) 20050301 |
Chronic stress in the adult dentate gyrus reduces cell proliferation near the vasculature and VEGF and Flk-1 protein expression. | The European journal of neuroscience 20050301 |
Novel anticholinesterases based on the molecular skeletons of furobenzofuran and methanobenzodioxepine. | Journal of medicinal chemistry 20050224 |
Behavioral sensitization to binge-pattern cocaine administration is not associated with changes in protein levels of four major G-proteins. | Brain research. Molecular brain research 20050218 |
Homogeneous distribution of large-conductance calcium-dependent potassium channels on soma and apical dendrite of rat neocortical layer 5 pyramidal neurons. | The European journal of neuroscience 20050201 |
A dissociation between the representation of tool-use skills and hand dominance: insights from left- and right-handed callosotomy patients. | Journal of cognitive neuroscience 20050201 |
Excitotoxic death induced by released glutamate in depolarized primary cultures of mouse cerebellar granule cells is dependent on GABAA receptors and niflumic acid-sensitive chloride channels. | The European journal of neuroscience 20050101 |
Morphine withdrawal increases intrinsic excitability of oxytocin neurons in morphine-dependent rats. | The European journal of neuroscience 20050101 |
HPA axis dysregulation following prenatal opiate exposure and postnatal withdrawal. | Neurotoxicology and teratology 20050101 |
Correlation between quantitative-EEG alterations and age in patients with interferon-alpha-treated hepatitis C. | Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society 20050101 |
Ovarian hormone withdrawal-induced 'depression' in female rats. | Physiology & behavior 20041215 |
Age- and sex-related disturbance in a battery of sensorimotor and cognitive tasks in Kunming mice. | Physiology & behavior 20041215 |
CGP 3466B has no effect on disease course of (G93A) mSOD1 transgenic mice. | Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases 20041201 |
Preclinical evidence for neuroprotection with monoamine oxidase-B inhibitors in Parkinson's disease. | Neurology 20041012 |
Clinical trials of neuroprotection for Parkinson's disease. | Neurology 20041012 |
Synthesis of 2-iodo-2-deoxy septanosides from a D-xylose-based oxepine: intramolecular cyclization in the absence of a glycosyl acceptor. | Carbohydrate research 20041004 |
Synthesis of medium ring heterocycles using an intramolecular Heck reaction. | Organic letters 20040819 |
Novel stereocontrolled approach to syn- and anti-oxepene-cyclogeranyl trans-fused polycyclic systems: asymmetric total synthesis of (-)-Aplysistatin, (+)-Palisadin A, (+)-Palisadin B, (+)-12-hydroxy-palisadin B, and the AB ring system of adociasulfate-2 and toxicol A. | Chemistry (Weinheim an der Bergstrasse, Germany) 20040806 |
Total synthesis of natural (+)-(2's,3'r)-zoapatanol. | Organic letters 20040624 |
Amyotrophic lateral sclerosis: a consensus viewpoint on designing and implementing a clinical trial. | Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases 20040601 |
Diastereoselective synthesis of cularine alkaloids via enium ions and an easy entry to isoquinolines by aza-Wittig electrocyclic ring closure. | The Journal of organic chemistry 20040430 |
Synthesis, crystal structure, and reactivity of a D-xylose based oxepine. | Carbohydrate research 20040428 |
Synthesis of 2-N,N-dimethylaminomethyl-2,3,3a,12b-tetrahydrodibenzo-[b,f]furo[2,3-d]oxepin derivatives as potential anxiolytic agents. | Chemical & pharmaceutical bulletin 20040201 |
Simultaneous analytical method for the determination of TCH346 and its four metabolites in human plasma by liquid chromatography/tandem mass spectrometry. | Rapid communications in mass spectrometry : RCM 20040101 |
Efficient syntheses of pterulone, pterulone B and related analogues. | Organic & biomolecular chemistry 20031207 |
Transient and stable transfection of Chinese hamster ovary cells with the recombinant feline erythropoietin gene and expression, purification, and biological activity of feline erythropoietin protein. | American journal of veterinary research 20031201 |
Enantioselective total synthesis of (+)-rogioloxepane A. | Organic letters 20030821 |
Intramolecular reactions of alkynes with furans and electron rich arenes catalyzed by PtCl2: the role of platinum carbenes as intermediates. | Journal of the American Chemical Society 20030514 |
CGP 3466 increases survival of cultured fetal dopaminergic neurons. | Restorative neurology and neuroscience 20030101 |
Multifunctional anti-angiogenic activity of the cyclic peroxide ANO-2 with antitumor activity. | International journal of cancer 20020710 |
Cycloaddition reactions of dihapto-coordinated furans. | Journal of the American Chemical Society 20020626 |
Modeling of binding modes and inhibition mechanism of some natural ligands of farnesyl transferase using molecular docking. | Journal of medicinal chemistry 20020328 |
Abundance and reactivity of dibenzodioxocins in softwood lignin. | Journal of agricultural and food chemistry 20020213 |
Two new sesquiterpene lactones from Montanoa tomentosa ssp. microcephala. | Planta medica 20011101 |
Non-steroidal and steroidal sulfamates: new drugs for cancer therapy. | Molecular and cellular endocrinology 20010122 |
Antiviral agents. Chemical modifications of a disulfide antibiotic, acetylaranotin. | Journal of medicinal chemistry 19740801 |
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