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288-92-6 | 1,2,4-thiadiazole
CAS No: 288-92-6 Catalog No: AG002WJP MDL No:
Product Description
Catalog Number:
AG002WJP
Chemical Name:
1,2,4-thiadiazole
CAS Number:
288-92-6
Molecular Formula:
C2H2N2S
Molecular Weight:
86.1157
IUPAC Name:
1,2,4-thiadiazole
InChI:
InChI=1S/C2H2N2S/c1-3-2-5-4-1/h1-2H
InChI Key:
YGTAZGSLCXNBQL-UHFFFAOYSA-N
SMILES:
c1ncns1
Properties
Complexity:
30.8
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
85.994g/mol
Formal Charge:
0
Heavy Atom Count:
5
Hydrogen Bond Acceptor Count:
3
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
86.112g/mol
Monoisotopic Mass:
85.994g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
54A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
0.8
Literature
| Title | Journal |
|---|---|
| Discovery of novel 1,2,4-thiadiazole derivatives as potent, orally active agonists of sphingosine 1-phosphate receptor subtype 1 (S1P(1)). | Journal of medicinal chemistry 20120510 |
| Optimizing thiadiazole analogues of resveratrol versus three chemopreventive targets. | Bioorganic & medicinal chemistry 20120101 |
| Ceftaroline in complicated skin and skin-structure infections. | Infection and drug resistance 20120101 |
| Antidepressant potential of nitrogen-containing heterocyclic moieties: An updated review. | Journal of pharmacy & bioallied sciences 20110101 |
| (2,6-Bis{5-amino-3-tert-butyl-4-[(3-methyl-1,2,4-thia-diazol-5-yl)diazen-yl]-1H-pyrazol-1-yl}-4-oxo-1,4-dihydro-1,3,5-triazin-1-ido)methanol(phenol)sodium phenol tetra-solvate. | Acta crystallographica. Section E, Structure reports online 20100401 |
| Efficient Electrochemical Synthesis, Antimicrobial and Antiinflammatory Activity of 2-amino-5-substituted- 1,3,4-oxadiazole Derivatives. | Indian journal of pharmaceutical sciences 20100101 |
| Allosteric modulation of adenosine receptors. | Purinergic signalling 20090301 |
| Reactivity of thiosemicarbazides with redox active metal ions: controlled formation of coordination complexes versus heterocyclic compounds. | Chemistry (Weinheim an der Bergstrasse, Germany) 20090101 |
| A computational investigation of the structure of polythiocyanogen. | Dalton transactions (Cambridge, England : 2003) 20081228 |
| Synthesis and structure-activity relationships of thiadiazole-derivatives as potent and orally active peroxisome proliferator-activated receptors alpha/delta dual agonists. | Bioorganic & medicinal chemistry 20080315 |
| Non-ATP competitive glycogen synthase kinase 3beta (GSK-3beta) inhibitors: study of structural requirements for thiadiazolidinone derivatives. | Bioorganic & medicinal chemistry 20080101 |
| Peroxisome Proliferators-Activated Receptor (PPAR) Modulators and Metabolic Disorders. | PPAR research 20080101 |
| Synthesis, Antimicrobial and Antiinflammatory Activity of 2,5-Disubstituted-1,3,4-oxadiazoles. | Indian journal of pharmaceutical sciences 20080101 |
| A rational chemical intervention strategy to circumvent bioactivation liabilities associated with a nonpeptidyl thrombopoietin receptor agonist containing a 2-amino-4-arylthiazole motif. | Chemical research in toxicology 20071201 |
| Synthesis and identification of [1,2,4]thiadiazole derivatives as a new series of potent and orally active dual agonists of peroxisome proliferator-activated receptors alpha and delta. | Journal of medicinal chemistry 20070809 |
| Design and synthesis of novel derivatives of the muscarinic agonist tetra(ethylene glycol)(3-methoxy-1,2,5-thiadiazol-4-yl) [3-(1-methyl-1,2,5,6-tetrahydropyrid-3-yl)-1,2,5-thiadiazol-4-yl] ether (CDD-0304): effects of structural modifications on the binding and activity at muscarinic receptor subtypes and chimeras. | Journal of medicinal chemistry 20061214 |
| Investigations on organo-sulfur-nitrogen rings and the thiocyanogen Polymer, (SCN)x. | Chemistry (Weinheim an der Bergstrasse, Germany) 20060816 |
| Advances in the synthesis and recent therapeutic applications of 1,2,4-thiadiazole heterocycles. | Bioorganic & medicinal chemistry 20060301 |
| Pharmacokinetic studies of a novel 1,2,4-thiadiazole derivative, inhibitor of Factor XIIIa, in the rabbit by a validated HPLC method. | Journal of pharmaceutical and biomedical analysis 20050615 |
| 1,2,4-thiadiazole: a novel Cathepsin B inhibitor. | Bioorganic & medicinal chemistry 20031201 |
| Synthesis and evaluation of novel dipeptide-bound 1,2,4-thiadiazoles as irreversible inhibitors of guinea pig liver transglutaminase. | Bioorganic & medicinal chemistry 20011201 |
| Cu(II)- and Hg(II)-induced modulation of the fluorescence behavior of a redox-active sensor molecule. | Inorganic chemistry 20010212 |
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