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288-14-2 | Isoxazole
CAS No: 288-14-2 Catalog No: AG002WJG MDL No:MFCD00003149
Product Description
Catalog Number:
AG002WJG
Chemical Name:
Isoxazole
CAS Number:
288-14-2
Molecular Formula:
C3H3NO
Molecular Weight:
69.0620
MDL Number:
MFCD00003149
IUPAC Name:
1,2-oxazole
InChI:
InChI=1S/C3H3NO/c1-2-4-5-3-1/h1-3H
InChI Key:
CTAPFRYPJLPFDF-UHFFFAOYSA-N
SMILES:
c1ccno1
EC Number:
206-018-7
UNII:
00SRW0M6PW
NSC Number:
137774
Properties
Complexity:
30.1
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
69.021g/mol
Formal Charge:
0
Heavy Atom Count:
5
Hydrogen Bond Acceptor Count:
2
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
69.063g/mol
Monoisotopic Mass:
69.021g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
26A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
0.1
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| Organocatalytic asymmetric synthesis of trifluoromethyl-substituted diarylpyrrolines: enantioselective conjugate cyanation of β-aryl-β-trifluoromethyl-disubstituted enones. | Angewandte Chemie (International ed. in English) 20120514 |
| CD74 and macrophage migration inhibitory factor as therapeutic targets in gastric cancer. | World journal of gastroenterology 20120514 |
| Design of a long-term antipsychotic in situ forming implant and its release control method and mechanism. | International journal of pharmaceutics 20120510 |
| Synthesis of 3,5-disubstituted isoxazoles via Cope-type hydroamination of 1,3-dialkynes. | Organic letters 20120504 |
| Inhibition of activator protein 1 signaling abrogates transforming growth factor β-mediated activation of fibroblasts and prevents experimental fibrosis. | Arthritis and rheumatism 20120501 |
| Experimental study of leflunomide on renal protective effect and on inflammatory response of streptozotocin induced diabetic rats. | Nephrology (Carlton, Vic.) 20120501 |
| Suppressive effect of an orally active MEK1/2 inhibitor in two different animal models for rheumatoid arthritis: a comparison with leflunomide. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20120501 |
| Combination of citalopram plus paliperidone is better than citalopram alone in the treatment of somatoform disorder: results of a 6-week randomized study. | International clinical psychopharmacology 20120501 |
| A randomized, placebo- and active-controlled study of paliperidone extended-release as maintenance treatment in patients with bipolar I disorder after an acute manic or mixed episode. | Journal of affective disorders 20120501 |
| Short-term effect of leflunomide in patients with Takayasu arteritis: an observational study. | Scandinavian journal of rheumatology 20120501 |
| Outcomes after anti-rheumatic drug use before and during pregnancy: a cohort study among 150,000 pregnant women and expectant fathers. | Scandinavian journal of rheumatology 20120501 |
| Novel isoxazole polycyclic aromatic hydrocarbons as DNA-intercalating agents. | European journal of medicinal chemistry 20120501 |
| Treatment of BK viremia in a pediatric heart transplant recipient. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20120501 |
| Parecoxib mitigates spatial memory impairment induced by sevoflurane anesthesia in aged rats. | Acta anaesthesiologica Scandinavica 20120501 |
| Development of a population pharmacokinetic model for parecoxib and its active metabolite valdecoxib after parenteral parecoxib administration in children. | Anesthesiology 20120501 |
| Discovery and structural development of small molecules that enhance transport activity of bile salt export pump mutant associated with progressive familial intrahepatic cholestasis type 2. | Bioorganic & medicinal chemistry 20120501 |
| Synthesis and biological evaluation of isoxazolo[4,5-d]pyridazin-4-(5H)-one analogues as potent anti-inflammatory agents. | Bioorganic & medicinal chemistry 20120501 |
| Trade-offs in defensive metabolite production but not ecological function in healthy and diseased sponges. | Journal of chemical ecology 20120501 |
| Isothiazole and isoxazole fused pyrimidones as PDE7 inhibitors: SAR and pharmacokinetic evaluation. | Bioorganic & medicinal chemistry letters 20120501 |
| Design and synthesis of 4-O-methylhonokiol analogs as inhibitors of cyclooxygenase-2 (COX-2) and PGF₁ production. | Bioorganic & medicinal chemistry 20120501 |
| Different safety profiles of risperidone and paliperidone extended-release: a double-blind, placebo-controlled trial with healthy volunteers. | Human psychopharmacology 20120501 |
| 5-Methyl-N-[2-(trifluoro-meth-yl)phen-yl]isoxazole-4-carboxamide. | Acta crystallographica. Section E, Structure reports online 20120501 |
| The Hsp90 inhibitor NVP-AUY922-AG inhibits NF-κB signaling, overcomes microenvironmental cytoprotection and is highly synergistic with fludarabine in primary CLL cells. | Oncotarget 20120501 |
| Immunotherapies in rheumatologic disorders. | The Medical clinics of North America 20120501 |
| Identification of imine or enamine drug metabolites using online hydrogen/deuterium exchange and exact mass measurements. | Rapid communications in mass spectrometry : RCM 20120430 |
| Benzodiazepines modulate GABAA receptors by regulating the preactivation step after GABA binding. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20120425 |
| Upregulation of high-affinity GABA(A) receptors in cultured rat dorsal root ganglion neurons. | Neuroscience 20120419 |
| [Sulphasalazine in patients with rheumatoid arthritis in China: a cross-sectional study]. | Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20120418 |
| Effects of zonisamide on tardive dyskinesia: a preliminary open-label trial. | Journal of the neurological sciences 20120415 |
| Case report: Multidrug-resistant cytomegalovirus in a modified multivisceral transplant recipient. | Transplantation 20120415 |
| Synthesis and biological evaluation of heterocyclic ring-fused betulinic acid derivatives as novel inhibitors of osteoclast differentiation and bone resorption. | Journal of medicinal chemistry 20120412 |
| GABA site agonist gaboxadol induces addiction-predicting persistent changes in ventral tegmental area dopamine neurons but is not rewarding in mice or baboons. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20120411 |
| High-performance liquid chromatographic enantioseparation of unusual isoxazoline-fused 2-aminocyclopentanecarboxylic acids on macrocyclic glycopeptide-based chiral stationary phases. | Journal of chromatography. A 20120406 |
| Disseminated cutaneous and visceral Kaposi sarcoma in a woman with rheumatoid arthritis receiving leflunomide. | Rheumatology international 20120401 |
| Effect of Mimosa pudica (Linn.) extract on anxiety behaviour and GABAergic regulation of 5-HT neuronal activity in the mouse. | Journal of psychopharmacology (Oxford, England) 20120401 |
| Effect of cytochrome P450 3A4 inhibitor ketoconazole on risperidone pharmacokinetics in healthy volunteers. | Journal of clinical pharmacy and therapeutics 20120401 |
| Pharmacokinetics and pharmacodynamics of A77 1726 and leflunomide in domestic cats. | Journal of veterinary pharmacology and therapeutics 20120401 |
| Leflunomide in dermatology. | Journal of the American Academy of Dermatology 20120401 |
| Strong anti-tumor effect of NVP-AUY922, a novel Hsp90 inhibitor, on non-small cell lung cancer. | Lung cancer (Amsterdam, Netherlands) 20120401 |
| Lack of association between CAG repeat polymorphism in the androgen receptor gene and the outcome of rheumatoid arthritis treatment with leflunomide. | European journal of clinical pharmacology 20120401 |
| Leflunomide for cytomegalovirus: bench to bedside. | Transplant infectious disease : an official journal of the Transplantation Society 20120401 |
| Relationship between dose, drug levels, and D2 receptor occupancy for the atypical antipsychotics risperidone and paliperidone. | The Journal of pharmacology and experimental therapeutics 20120401 |
| Short-term efficacy and safety of zonisamide as adjunctive treatment for refractory partial seizures: a multicenter open-label single-arm trial in Korean patients. | Seizure 20120401 |
| Diarylheterocycle core ring features effect in selective COX-1 inhibition. | ChemMedChem 20120401 |
| Variability of retention process of isoxaflutole and its diketonitrile metabolite in soil under conventional and conservation tillage. | Pest management science 20120401 |
| Synthesis and biological activities of novel isoxazoline-linked pseudodisaccharide derivatives. | Carbohydrate research 20120401 |
| Practical guidelines on the use of paliperidone palmitate in schizophrenia. | Current medical research and opinion 20120401 |
| Transfer of parecoxib and its primary active metabolite valdecoxib via transitional breastmilk following intravenous parecoxib use after cesarean delivery: a comparison of naive pooled data analysis and nonlinear mixed-effects modeling. | Anesthesia and analgesia 20120401 |
| Synthesis of heterocyclic N-(β-D-glucopyranosyl)carboxamides for inhibition of glycogen phosphorylase. | Carbohydrate research 20120401 |
| A randomized, placebo-controlled study of zonisamide to prevent olanzapine-associated weight gain. | Journal of clinical psychopharmacology 20120401 |
| Multi-component synthesis and in vitro and in vivo anticancer activity of novel arylmethylene bis-isoxazolo[4,5-b]pyridine-N-oxides. | European journal of medicinal chemistry 20120401 |
| Predicting plasma concentration of risperidone associated with dosage change: a population pharmacokinetic study. | Therapeutic drug monitoring 20120401 |
| Design, synthesis, in vitro antimicrobial and anticancer activity of novel methylenebis-isoxazolo[4,5-b]azepines derivatives. | European journal of medicinal chemistry 20120401 |
| Catatonia and encephalopathy associated with paliperidone palmitate. | Journal of clinical psychopharmacology 20120401 |
| Generation and exploration of new classes of antitubercular agents: The optimization of oxazolines, oxazoles, thiazolines, thiazoles to imidazo[1,2-a]pyridines and isomeric 5,6-fused scaffolds. | Bioorganic & medicinal chemistry 20120401 |
| Impact of antiepileptic drugs on genesis of psychosis. | Epilepsy & behavior : E&B 20120401 |
| A stability-indicating ultra-performance liquid chromatographic method for estimation of related substances and degradants in paliperidone active pharmaceutical ingredient and its pharmaceutical dosage forms. | Journal of chromatographic science 20120401 |
| Low serum leptin level is associated with zonisamide-induced weight loss in overweight female epilepsy patients. | Epilepsy & behavior : E&B 20120401 |
| Iloperidone for the treatment of schizophrenia: an updated clinical review. | Clinical schizophrenia & related psychoses 20120401 |
| Development and validation of an improved algorithm for overlaying flexible molecules. | Journal of computer-aided molecular design 20120401 |
| (E)-Benzaldehyde O-{[3-(pyridin-3-yl)isoxazol-5-yl]meth-yl}oxime. | Acta crystallographica. Section E, Structure reports online 20120401 |
| Ethyl 5-(4-amino-phen-yl)isoxazole-3-carboxyl-ate. | Acta crystallographica. Section E, Structure reports online 20120401 |
| Synthesis and antimicrobial activity of N'-heteroarylidene-1-adamantylcarbohydrazides and (±)-2-(1-adamantyl)-4-acetyl-5-[5-(4-substituted phenyl-3-isoxazolyl)]-1,3,4-oxadiazolines. | Molecules (Basel, Switzerland) 20120316 |
| Effects of the selective kainate receptor antagonist ACET on altered sensorimotor gating in a genetic model of reduced NMDA receptor function. | Brain research 20120314 |
| Intracellular chloride concentration influences the GABAA receptor subunit composition. | Nature communications 20120313 |
| Efficient synthesis of C2v-symmetrical pentakisadducts of C60 as versatile building blocks for fullerene architectures that involve a mixed octahedral addition pattern. | Chemistry (Weinheim an der Bergstrasse, Germany) 20120312 |
| Stereoselective synthesis of 1-nitrobicyclo[3.1.0]hexanes and fused isoxazoline-N-oxides from primary nitro compounds. | The Journal of organic chemistry 20120302 |
| Synthesis of benzisoxazolines by the coupling of arynes with nitrones. | The Journal of organic chemistry 20120302 |
| Therapeutic effect of leflunomide on the development of experimental lupus nephritis in mice. | Rheumatology international 20120301 |
| Causes of DMARD withdrawal following ADR within 6 months of initiation among Indian rheumatoid arthritis patients. | Rheumatology international 20120301 |
| [Stimulant and non-stimulant medication in current and future therapy for ADHD]. | Fortschritte der Neurologie-Psychiatrie 20120301 |
| Modulating human proteinase activated receptor 2 with a novel antagonist (GB88) and agonist (GB110). | British journal of pharmacology 20120301 |
| Analysis of gene variants previously associated with iloperidone response in patients with schizophrenia who are treated with risperidone. | The Journal of clinical psychiatry 20120301 |
| HRD1 levels increased by zonisamide prevented cell death and caspase-3 activation caused by endoplasmic reticulum stress in SH-SY5Y cells. | Journal of molecular neuroscience : MN 20120301 |
| D-Amino acid oxidase-mediated increase in spinal hydrogen peroxide is mainly responsible for formalin-induced tonic pain. | British journal of pharmacology 20120301 |
| Effectiveness of disease-modifying antirheumatic drug co-therapy with methotrexate and leflunomide in rituximab-treated rheumatoid arthritis patients: results of a 1-year follow-up study from the CERERRA collaboration. | Annals of the rheumatic diseases 20120301 |
| Synthesis and antimicrobial evaluation of some new cyclooctanones and cyclooctane-based heterocycles. | Archiv der Pharmazie 20120301 |
| On the mode of action of the herbicides cinmethylin and 5-benzyloxymethyl-1, 2-isoxazolines: putative inhibitors of plant tyrosine aminotransferase. | Pest management science 20120301 |
| EP2 and EP4 receptors on muscularis resident macrophages mediate LPS-induced intestinal dysmotility via iNOS upregulation through cAMP/ERK signals. | American journal of physiology. Gastrointestinal and liver physiology 20120301 |
| Effects of general anaesthetics on 5-HT neuronal activity in the dorsal raphe nucleus. | Neuropharmacology 20120301 |
| New inhibitors of dihydroorotate dehydrogenase (DHODH) based on the 4-hydroxy-1,2,5-oxadiazol-3-yl (hydroxyfurazanyl) scaffold. | European journal of medicinal chemistry 20120301 |
| Comparative bioequivalence study of leflunomide tablets in Indian healthy volunteers. | Arzneimittel-Forschung 20120301 |
| Native kidney BK virus nephropathy associated with chronic lymphocytic leukaemia. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20120301 |
| Prolongation of cardiac ventricular repolarization under paliperidone: how and how much? | Journal of cardiovascular pharmacology 20120301 |
| Publication bias in antipsychotic trials: an analysis of efficacy comparing the published literature to the US Food and Drug Administration database. | PLoS medicine 20120301 |
| Gintonin, newly identified compounds from ginseng, is novel lysophosphatidic acids-protein complexes and activates G protein-coupled lysophosphatidic acid receptors with high affinity. | Molecules and cells 20120227 |
| Synthetic studies directed toward dideoxy lomaiviticinone lead to unexpected 1,2-oxazepine and isoxazole formation. | Organic letters 20120217 |
| Expedient synthesis of a 72-membered isoxazolino-β-ketoamide library by a 2·3-component reaction. | ACS combinatorial science 20120213 |
| Acid-base-catalysed condensation reaction in water: isoxazolines and isoxazoles from nitroacetates and dipolarophiles. | Chemistry (Weinheim an der Bergstrasse, Germany) 20120213 |
| Falsely decreased ionized calcium results due to analytical interference by teriflunomide, the active metabolite of leflunomide (Arava®). | Clinical chemistry and laboratory medicine 20120210 |
| Identification of 1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea hydrochloride (CEP-32496), a highly potent and orally efficacious inhibitor of V-RAF murine sarcoma viral oncogene homologue B1 (BRAF) V600E. | Journal of medicinal chemistry 20120209 |
| Assessment of treatment algorithms including amantadine, metformin, and zonisamide for the prevention of weight gain with olanzapine: a randomized controlled open-label study. | The Journal of clinical psychiatry 20120201 |
| Delayed administration of parecoxib, a specific COX-2 inhibitor, attenuated postischemic neuronal apoptosis by phosphorylation Akt and GSK-3β. | Neurochemical research 20120201 |
| Cyclooxygenase inhibitors decrease the growth and induce regression of human esophageal adenocarcinoma xenografts in nude mice. | International journal of oncology 20120201 |
| Clinical pharmacology of paliperidone palmitate a parenteral long-acting formulation for the treatment of schizophrenia. | Reviews on recent clinical trials 20120201 |
| An aggregation sensing reporter identifies leflunomide and teriflunomide as polyglutamine aggregate inhibitors. | Human molecular genetics 20120201 |
| Tonic GABAA receptor conductance in medial subnucleus of the tractus solitarius neurons is inhibited by activation of μ-opioid receptors. | Journal of neurophysiology 20120201 |
| Stepwise synchronization through the corpus callosum is one cause of myoclonic jerks. | World neurosurgery 20120201 |
| Synthesis and evaluation of hexahydropyrrolo[3,4-d]isoxazole-4,6-diones as anti-stress agents. | European journal of medicinal chemistry 20120201 |
| Acute renal failure after paliperidone overdose: a case report. | Journal of clinical psychopharmacology 20120201 |
| Parkinsonism and rabbit syndrome after discontinuation of low-dose ziprasidone and concomitant initiation of sertraline. | Journal of clinical psychopharmacology 20120201 |
| Fixed drug eruption caused by etoricoxib with tolerance to celecoxib and parecoxib. | Contact dermatitis 20120201 |
| [ Bone and cartilage destruction in RA and its intervention. Disease-modifying antirheumatic drugs]. | Clinical calcium 20120201 |
| A change from risperidone long acting injection to paliperidone palmitate in an elderly patient--a cautionary tale. | The Australian and New Zealand journal of psychiatry 20120201 |
| (2S,5S,6R)-5-(4-Methyl-phen-yl)-3-phenyl-4,8-dioxa-3-aza-tricyclo-[7.4.0.0]trideca-1(13),9,11-triene-6-carbonitrile. | Acta crystallographica. Section E, Structure reports online 20120201 |
| 4-Hy-droxy-3,5-dimeth-oxy-N-{4-[(5-methyl-1,2-oxazol-3-yl)sulfamo-yl]phen-yl}benzamide methanol monosolvate. | Acta crystallographica. Section E, Structure reports online 20120201 |
| [Off-label therapy of rheumatoid arthritis and spondyloarthritis]. | Zeitschrift fur Rheumatologie 20120201 |
| Fragment-based discovery of bromodomain inhibitors part 2: optimization of phenylisoxazole sulfonamides. | Journal of medicinal chemistry 20120126 |
| Identification of novel α4β2-nicotinic acetylcholine receptor (nAChR) agonists based on an isoxazole ether scaffold that demonstrate antidepressant-like activity. | Journal of medicinal chemistry 20120126 |
| Regioselective synthesis of 3-arylamino- and 5-arylaminoisoxazoles from enaminones. | Organic letters 20120120 |
| Targeting the restricted α-subunit repertoire of airway smooth muscle GABAA receptors augments airway smooth muscle relaxation. | American journal of physiology. Lung cellular and molecular physiology 20120115 |
| Leflunomide induces apoptosis in fludarabine-resistant and clinically refractory CLL cells. | Clinical cancer research : an official journal of the American Association for Cancer Research 20120115 |
| A tea catechin, epigallocatechin-3-gallate, is a unique modulator of the farnesoid X receptor. | Toxicology and applied pharmacology 20120115 |
| Synthesis of functionalized 2,3-dihydroisoxazoles by domino reactions in water and unexpected ring-opening reactions of 2,3-dihydroisoxazoles. | Organic & biomolecular chemistry 20120114 |
| Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors. | Journal of medicinal chemistry 20120112 |
| Neurotoxic/neuroprotective activity of haloperidol, risperidone and paliperidone in neuroblastoma cells. | Progress in neuro-psychopharmacology & biological psychiatry 20120110 |
| Libraries of 2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-amine derivatives via a multicomponent assembly process/1,3-dipolar cycloaddition strategy. | ACS combinatorial science 20120109 |
| A screen for enhancers of clearance identifies huntingtin as a heat shock protein 90 (Hsp90) client protein. | The Journal of biological chemistry 20120106 |
| Impaired generation of 12-hydroxylated bile acids links hepatic insulin signaling with dyslipidemia. | Cell metabolism 20120104 |
| Molecular recognition at the active site of factor Xa: cation-π interactions, stacking on planar peptide surfaces, and replacement of structural water. | Chemistry (Weinheim an der Bergstrasse, Germany) 20120102 |
| Evaluation of the efficacy and safety of paliperidone extended-release in the treatment of acute mania: a randomized, double-blind, dose-response study. | Journal of affective disorders 20120101 |
| Leflunomide use in a cytomegalovirus infection of a patient with dermatomyositis. | Rheumatology international 20120101 |
| Tissue biochemical alterations of Cyprinus carpio exposed to commercial herbicide containing clomazone under rice-field conditions. | Archives of environmental contamination and toxicology 20120101 |
| Dramatic response to zonisamide of post-subarachnoid hemorrhage Holmes' tremor. | Journal of neurology 20120101 |
| Small molecule-based disruption of the Axin/β-catenin protein complex regulates mesenchymal stem cell differentiation. | Cell research 20120101 |
| Efficacy of leflunomide addition in relation to prognostic factors for patients with active early rheumatoid arthritis failing to methotrexate in daily practice. | Clinical rheumatology 20120101 |
| Inhibition of apical sodium-dependent bile acid transporter as a novel treatment for diabetes. | American journal of physiology. Endocrinology and metabolism 20120101 |
| Race and sex differences in response to endothelin receptor antagonists for pulmonary arterial hypertension. | Chest 20120101 |
| Comparison of anti-invasive activity of parthenolide and 3-isopropyl-2-methyl-4-methyleneisoxazolidin-5-one (MZ-6)--a new compound with α-methylene-γ-lactone motif--on two breast cancer cell lines. | Chemical biology & drug design 20120101 |
| The effects of leflunomide on CD4(+)CD25 (+)Foxp3 (+) T regulatory cells in mice receiving allogeneic bone marrow transplantation. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20120101 |
| Riluzole elevates GLT-1 activity and levels in striatal astrocytes. | Neurochemistry international 20120101 |
| Short stay and less pain after ambulatory anterior cruciate ligament (ACL) repair: COX-2 inhibitor versus glucocorticoid versus both combined. | Acta anaesthesiologica Scandinavica 20120101 |
| Synthesis, antimicrobial, antimycobacterial and structure-activity relationship of substituted pyrazolo-, isoxazolo-, pyrimido- and mercaptopyrimidocyclohepta[b]indoles. | European journal of medicinal chemistry 20120101 |
| Isoxazoles incorporated N-substituted decahydroquinolines: a precursor to the next generation antimicrobial drug. | European journal of medicinal chemistry 20120101 |
| Design and diversity-oriented synthesis of novel 1,4-thiazepan-3-ones fused with bioactive heterocyclic skeletons and evaluation of their antioxidant and cytotoxic activities. | Bioorganic & medicinal chemistry letters 20120101 |
| QT prolongation of the antipsychotic risperidone is predominantly related to its 9-hydroxy metabolite paliperidone. | Human psychopharmacology 20120101 |
| Synthesis and in vitro and in vivo anticancer activity of novel phenylmethylene bis-isoxazolo[4,5-b]azepines. | Bioorganic & medicinal chemistry letters 20120101 |
| Oral-paliperidone-induced tardive dyskinesia: a case report. | General hospital psychiatry 20120101 |
| Efficacy of iloperidone in the short-term treatment of schizophrenia: a post hoc analysis of pooled patient data from four phase III, placebo- and active-controlled trials. | Human psychopharmacology 20120101 |
| Synthesis and evaluation of novel 4-[(3H,3aH,6aH)-3-phenyl)-4,6-dioxo-2-phenyldihydro-2H-pyrrolo[3,4-d]isoxazol-5(3H,6H,6aH)-yl]benzoic acid derivatives as potent acetylcholinesterase inhibitors and anti-amnestic agents. | Bioorganic & medicinal chemistry 20120101 |
| Anaphylactoid reaction to paliperidone palmitate extended-release injectable suspension in a patient tolerant of oral risperidone. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20120101 |
| Effects of paliperidone extended release on the symptoms and functioning of schizophrenia. | BMC clinical pharmacology 20120101 |
| Glutathione and Bcl-2 targeting facilitates elimination by chemoradiotherapy of human A375 melanoma xenografts overexpressing bcl-xl, bcl-2, and mcl-1. | Journal of translational medicine 20120101 |
| AHR2 mutant reveals functional diversity of aryl hydrocarbon receptors in zebrafish. | PloS one 20120101 |
| Weight-reducing side effects of the antiepileptic agents topiramate and zonisamide. | Handbook of experimental pharmacology 20120101 |
| Diaqua-bis-(5-methyl-1,2-oxazole-3-car-box-yl-ato-κN,O)cobalt(II) dihydrate. | Acta crystallographica. Section E, Structure reports online 20120101 |
| Derivatives of 3-isoxazolecarboxylic acid esters: a potent and selective compound class against replicating and nonreplicating Mycobacterium tuberculosis. | Current topics in medicinal chemistry 20120101 |
| An effective technique for salvage of cardiac-related devices. | Eplasty 20120101 |
| Ritonavir-induced lipoatrophy and dyslipidaemia is reversed by the anti-inflammatory drug leflunomide in a PPAR-γ-dependent manner. | Antiviral therapy 20120101 |
| Alopecia areata during treatment of psoriasis with adalimumab and leflunomide: a case and review of the literature. | Skin pharmacology and physiology 20120101 |
| The threshold rate of oral atypical anti-psychotic adherence at which paliperidone palmitate is cost saving. | Journal of medical economics 20120101 |
| Interstitial lung disease related to rheumatoid arthritis: evolution after treatment. | Reumatologia clinica 20120101 |
| Radiosensitization of normoxic and hypoxic h1339 lung tumor cells by heat shock protein 90 inhibition is independent of hypoxia inducible factor-1α. | PloS one 20120101 |
| Leflunomide in monotherapy of rheumatoid arthritis: meta-analysis of randomized trials. | Polskie Archiwum Medycyny Wewnetrznej 20120101 |
| [Efficacy, tolerability and safety of paliperidone extended-release in the treatment of schizophrenia and schizoaffective disorder]. | Rivista di psichiatria 20120101 |
| Targeting lysophosphatidic acid signaling retards culture-associated senescence of human marrow stromal cells. | PloS one 20120101 |
| Cytotoxic effects of chemotherapeutic drugs and heterocyclic compounds at application on the cells of primary culture of neuroepithelium tumors. | Medicinal chemistry (Shariqah (United Arab Emirates)) 20120101 |
| In situ nondestructive sediment characterization and resuspendability evaluation of concentrated aqueous paliperidone palmitate suspensions in prefilled syringes by low-field one-dimensional pulsed-field gradient NMR profilometry. | Pharmaceutical development and technology 20120101 |
| α7 nicotinic ACh receptors as a ligand-gated source of Ca(2+) ions: the search for a Ca(2+) optimum. | Advances in experimental medicine and biology 20120101 |
| A one-year prospective study of the safety, tolerability and pharmacokinetics of the highest available dose of paliperidone palmitate in patients with schizophrenia. | BMC psychiatry 20120101 |
| Cost effectiveness of paliperidone palmitate versus risperidone long-acting injectable and olanzapine pamoate for the treatment of patients with schizophrenia in Sweden. | Journal of medical economics 20120101 |
| The reactivity of gem cyanoester ketene dithiolates towards the development of potent antioxidant heterocycles. | Chemical & pharmaceutical bulletin 20120101 |
| Somatic integration of single ion channel responses of α7 nicotinic acetylcholine receptors enhanced by PNU-120596. | PloS one 20120101 |
| The HSP90 inhibitor NVP-AUY922 radiosensitizes by abrogation of homologous recombination resulting in mitotic entry with unresolved DNA damage. | PloS one 20120101 |
| Farnesoid X receptor induces murine scavenger receptor Class B type I via intron binding. | PloS one 20120101 |
| Gintonin, a ginseng-derived lysophosphatidic acid receptor ligand, attenuates Alzheimer's disease-related neuropathies: involvement of non-amyloidogenic processing. | Journal of Alzheimer's disease : JAD 20120101 |
| The HIV matrix protein p17 subverts nuclear receptors expression and induces a STAT1-dependent proinflammatory phenotype in monocytes. | PloS one 20120101 |
| On-farm bioremediation of dimethazone and trifluralin residues in runoff water from an agricultural field. | Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 20120101 |
| Application of 2-trichloromethylbenzimidazole in analytical chemistry: a highly selective chromogenic reagent for thin-layer chromatography and some other analytical uses. | Journal of analytical methods in chemistry 20120101 |
| [Another discussion of membrane voltage alterations in growing pollen tube]. | Tsitologiia 20120101 |
| Gastrointestinal stromal tumors: a review of case reports, diagnosis, treatment, and future directions. | ISRN gastroenterology 20120101 |
| Docking studies, synthesis, characterization and evaluation of their antioxidant and cytotoxic activities of some novel isoxazole-substituted 9-anilinoacridine derivatives. | TheScientificWorldJournal 20120101 |
| Ultraviolet C irradiation induces different expression of cyclooxygenase 2 in NIH 3T3 cells and A431 cells: the roles of COX-2 are different in various cell lines. | International journal of molecular sciences 20120101 |
| The nicotinic acetylcholine receptor as a target for antidepressant drug development. | TheScientificWorldJournal 20120101 |
| The chemoselective reduction of isoxazoline γ-lactams through iminium Aza-Diels-Alder reactions: a short-cut synthesis of aminols as valuable intermediates towards nucleoside derivatives. | TheScientificWorldJournal 20120101 |
| Macrophage migration inhibitory factor antagonist blocks the development of endometriosis in vivo. | PloS one 20120101 |
| Inhibition of ion channels and heart beat in Drosophila by selective COX-2 inhibitor SC-791. | PloS one 20120101 |
| [Possibilities of the treatment of exacerbations of schizophrenia with the long acting atypical antipsychotic paliperidone palmitate]. | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20120101 |
| Evaluation of 3-(3-chloro-phenyl)-5-(4-pyridyl)-4,5-dihydroisoxazole as a novel anti-inflammatory drug candidate. | PloS one 20120101 |
| Effect of the cytochrome P450 2D6*10 allele on risperidone metabolism in Japanese psychiatric patients. | Human psychopharmacology 20120101 |
| Efficacy of leflunomide 100mg weekly compared to low dose methotrexate in patients with active rheumatoid arthritis. Double blind, randomized clinical trial. | Reumatologia clinica 20120101 |
| Preemptive analgesic efficacy of parecoxib vs placebo in infertile women undergoing diagnostic laparoscopy: randomized controlled trial. | Journal of minimally invasive gynecology 20120101 |
| Angioedema occurring in patient prescribed iloperidone and haloperidol: a cross-sensitivity reaction to antipsychotics from different chemical classes. | The Journal of neuropsychiatry and clinical neurosciences 20120101 |
| A randomized, double-blind, controlled trial on non-opioid analgesics and opioid consumption for postoperative pain relief after laparoscopic cholecystectomy. | Acta anaesthesiologica Belgica 20120101 |
| Exacerbation of AIH in a patient with an AIH/systemic sclerosis overlap syndrome and pulmonary arterial hypertension treated with the endothelin-1 receptor antagonist sitaxentan. | BMJ case reports 20120101 |
| Iontophoresis of endothelin receptor antagonists in rats and men. | PloS one 20120101 |
| The aryl hydrocarbon receptor mediates leflunomide-induced growth inhibition of melanoma cells. | PloS one 20120101 |
| A multicenter, randomized, double-blind study comparing different FK778 doses (manitimus) with tacrolimus and steroids vs. MMF with tacrolimus and steroids in renal transplantation. | BMC nephrology 20120101 |
| Treatment with paliperidone in children with behavior disorders previously treated with risperidone: an open-label trial. | Clinical neuropharmacology 20120101 |
| Immunosuppressive treatment for nephrotic idiopathic membranous nephropathy: a meta-analysis based on Chinese adults. | PloS one 20120101 |
| Similarities between exogenously- and endogenously-induced envelope stress: the effects of a new antibacterial molecule, TPI1609-10. | PloS one 20120101 |
| Aripiprazole reverses paliperidone-induced hyperprolactinemia. | Actas espanolas de psiquiatria 20120101 |
| Zonisamide: its pharmacology, efficacy and safety in clinical trials. | Acta neurologica Scandinavica. Supplementum 20120101 |
| Zonisamide in clinical practice. | Acta neurologica Scandinavica. Supplementum 20120101 |
| A DFT study of pyrrole-isoxazole derivatives as chemosensors for fluoride anion. | International journal of molecular sciences 20120101 |
| Adsorption mechanisms of isoxazole and oxazole on Si(100)-2 × 1 surface: Si-N dative bond addition vs. [4+2] cycloaddition. | The Journal of chemical physics 20111228 |
| Novel 3,4-isoxazolediamides as potent inhibitors of chaperone heat shock protein 90. | Journal of medicinal chemistry 20111222 |
| Regioselective synthesis and slow-release Suzuki-Miyaura cross-coupling of MIDA boronate-functionalized isoxazoles and triazoles. | The Journal of organic chemistry 20111216 |
| A randomized, double-blind study of paliperidone extended-release in treatment of acute schizophrenia in adolescents. | Biological psychiatry 20111215 |
| Use of comprehensive screening methods to detect selective human CAR activators. | Biochemical pharmacology 20111215 |
| Synthesis and bio-evaluation of human macrophage migration inhibitory factor inhibitor to develop anti-inflammatory agent. | Bioorganic & medicinal chemistry 20111215 |
| Development of isoxazoline-containing peptidomimetics as dual αvβ3 and α5β1 integrin ligands. | ChemMedChem 20111209 |
| Development and validation of an analytical method based on high performance thin layer chromatography for the simultaneous determination of lamotrigine, zonisamide and levetiracetam in human plasma. | Journal of pharmaceutical and biomedical analysis 20111205 |
| Reversible erectile dysfunction in a patient with brain tumor-related epilepsy in therapy with zonisamide in add-on. | The journal of sexual medicine 20111201 |
| Cutaneous lupus erythematosus: update of therapeutic options part II. | Journal of the American Academy of Dermatology 20111201 |
| Social interaction and drug attitude effectiveness in patients with schizophrenia. | The Psychiatric quarterly 20111201 |
| The neurological safety of epidural parecoxib in rats. | Neurotoxicology 20111201 |
| Zonisamide produces weight loss in psychotropic drug-treated psychiatric outpatients. | Progress in neuro-psychopharmacology & biological psychiatry 20111201 |
| Competitive binding at a nicotinic receptor transmembrane site of two α7-selective positive allosteric modulators with differing effects on agonist-evoked desensitization. | Neuropharmacology 20111201 |
| Immunosuppressive effects and mechanisms of leflunomide in dengue virus infection of human dendritic cells. | Journal of clinical immunology 20111201 |
| Comparative effectiveness of rituximab in combination with either methotrexate or leflunomide in the treatment of rheumatoid arthritis. | Seminars in arthritis and rheumatism 20111201 |
| Investigation of the molecular mechanism of the α7 nicotinic acetylcholine receptor positive allosteric modulator PNU-120596 provides evidence for two distinct desensitized states. | Molecular pharmacology 20111201 |
| Gastric epithelial cell death caused by Helicobacter suis and Helicobacter pylori γ-glutamyl transpeptidase is mainly glutathione degradation-dependent. | Cellular microbiology 20111201 |
| Heat shock protein 90 inhibitor is synergistic with JAK2 inhibitor and overcomes resistance to JAK2-TKI in human myeloproliferative neoplasm cells. | Clinical cancer research : an official journal of the American Association for Cancer Research 20111201 |
| Leflunomide pharmacokinetics after single oral administration to dogs. | Journal of veterinary pharmacology and therapeutics 20111201 |
| New spirocyclic Δ²-isoxazoline derivatives related to selective agonists of α7 neuronal nicotinic acetylcholine receptors. | European journal of medicinal chemistry 20111201 |
| [Maintainance treatment of anti-neutrophil cytoplasm associated antibodies (ANCA)]. | Reumatologia clinica 20111201 |
| Patients with eating disorders (ED) treated with Zonisamide. | Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) 20111201 |
| N-(2,6-Dichloro-phen-yl)-5-methyl-1,2-oxazole-4-carboxamide monohydrate. | Acta crystallographica. Section E, Structure reports online 20111201 |
| N-(4-Chloro-2-nitro-phen-yl)-5-methyl-isoxazole-4-carboxamide. | Acta crystallographica. Section E, Structure reports online 20111201 |
| The pyrolysis of isoxazole revisited: a new primary product and the pivotal role of the vinylnitrene. A low-temperature matrix isolation and computational study. | Journal of the American Chemical Society 20111123 |
| Inhibiting effects of Leflunomide metabolite on overexpression of CD147, MMP-2 and MMP-9 in PMA differentiated THP-1 cells. | European journal of pharmacology 20111116 |
| Synthesis and biochemical evaluation of δ(2)-isoxazoline derivatives as DNA methyltransferase 1 inhibitors. | Journal of medicinal chemistry 20111110 |
| Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans. | Nature chemical biology 20111106 |
| Chameleonic reactivity of vicinal diazonium salt of acetylenyl-9,10-anthraquinones: synthetic application toward two heterocyclic targets. | The Journal of organic chemistry 20111104 |
| Effectiveness and safety of leflunomide for pulmonary and extrapulmonary sarcoidosis. | The European respiratory journal 20111101 |
| Clarithromycin inhibits interleukin-13-induced goblet cell hyperplasia in human airway cells. | American journal of respiratory cell and molecular biology 20111101 |
| Alteration of ethanol drinking in mice via modulation of the GABA(A) receptor with ganaxolone, finasteride, and gaboxadol. | Alcoholism, clinical and experimental research 20111101 |
| Possible drug-induced hepatopathy in a dog receiving zonisamide monotherapy for treatment of cryptogenic epilepsy. | The Journal of veterinary medical science 20111101 |
| A critical role of NO/cGMP/PKG dependent pathway in hippocampal post-ischemic LTP: modulation by zonisamide. | Neurobiology of disease 20111101 |
| Acidic residue modifications restore chaperone activity of β-casein interacting with lysozyme. | International journal of biological macromolecules 20111101 |
| In vitro activity of a novel broad-spectrum antifungal, E1210, tested against Aspergillus spp. determined by CLSI and EUCAST broth microdilution methods. | Antimicrobial agents and chemotherapy 20111101 |
| Pre-clinical development of antifungal susceptibility test methods for the testing of the novel antifungal agent E1210 versus Candida: comparison of CLSI and European Committee on Antimicrobial Susceptibility Testing methods. | The Journal of antimicrobial chemotherapy 20111101 |
| Lysophosphatidic acid induces erythropoiesis through activating lysophosphatidic acid receptor 3. | Stem cells (Dayton, Ohio) 20111101 |
| Zonisamide in the treatment of epilepsy. | Expert opinion on pharmacotherapy 20111101 |
| Binding of isoxazole and pyrazole derivatives of curcumin with the activator binding domain of novel protein kinase C. | Bioorganic & medicinal chemistry 20111101 |
| Triclosan, an environmental pollutant from health care products, evokes charybdotoxin-sensitive hyperpolarization in rat thymocytes. | Environmental toxicology and pharmacology 20111101 |
| Formation of ionized arylamines upon electron ionization of N-aryl-methyl-isoxazole-4-carboxamides: correlation with Hammett's constants and arylamine pKb's mass spectra of arylmethylisoxazolecarboxamides. | Journal of mass spectrometry : JMS 20111101 |
| 3-[Chloro-(phen-yl)meth-yl]-6-methyl-1,2-benzoxazole. | Acta crystallographica. Section E, Structure reports online 20111101 |
| rac-Ethyl 6-hy-droxy-6-methyl-3-oxo-4-phenyl-1,3,4,5,6,7-hexa-hydro-benzo[c][1,2]oxazole-5-carboxyl-ate. | Acta crystallographica. Section E, Structure reports online 20111101 |
| Discovery of isoxazole analogues of sazetidine-A as selective α4β2-nicotinic acetylcholine receptor partial agonists for the treatment of depression. | Journal of medicinal chemistry 20111027 |
| N-heterocyclic carbene-catalyzed 1,3-dipolar cycloaddition reactions: a facile synthesis of 3,5-di- and 3,4,5-trisubstituted isoxazoles. | Organic & biomolecular chemistry 20111026 |
| [Systemic autoimmune disorders and pregnancy]. | Orvosi hetilap 20111023 |
| The chimeric gene CHRFAM7A, a partial duplication of the CHRNA7 gene, is a dominant negative regulator of α7*nAChR function. | Biochemical pharmacology 20111015 |
| Conformationally constrained farnesoid X receptor (FXR) agonists: alternative replacements of the stilbene. | Bioorganic & medicinal chemistry letters 20111015 |
| EEG power spectra response to a 4-h phase advance and gaboxadol treatment in 822 men and women. | Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 20111015 |
| 3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands. | Journal of medicinal chemistry 20111013 |
| [Treatment of rheumatic diseases: current status and future prospective. Topics: II. Immunosuppressant/antirheumatic drugs; 5. Leflunomide and mizoribine]. | Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20111010 |
| Three-component coupling approach to trachyspic acid. | Organic letters 20111007 |
| Catalytic asymmetric 1,6-Michael addition of arylthiols to 3-methyl-4-nitro-5-alkenyl-isoxazoles with bifunctional catalysts. | The Journal of organic chemistry 20111007 |
| The BK virus in renal transplant recipients-review of pathogenesis, diagnosis, and treatment. | Pediatric nephrology (Berlin, Germany) 20111001 |
| Neuroprotection of paliperidone on SH-SY5Y cells against β-amyloid peptide(25-35), N-methyl-4-phenylpyridinium ion, and hydrogen peroxide-induced cell death. | Psychopharmacology 20111001 |
| A series of complications after third molar osteotomy in a pancytopenia patient and spontaneous healing after bone marrow transplantation. | Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20111001 |
| Effects of acute paliperidone palmitate treatment in subjects with schizophrenia recently treated with oral risperidone. | Schizophrenia research 20111001 |
| Leflunomide with low-dose everolimus for treatment of Kaposi's sarcoma in a renal allograft recipient. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20111001 |
| Molecular basis for the high THIP/gaboxadol sensitivity of extrasynaptic GABA(A) receptors. | Journal of neurophysiology 20111001 |
| Lysophosphatidic acid receptor 1 modulates lipopolysaccharide-induced inflammation in alveolar epithelial cells and murine lungs. | American journal of physiology. Lung cellular and molecular physiology 20111001 |
| In vitro activity of E1210, a novel antifungal, against clinically important yeasts and molds. | Antimicrobial agents and chemotherapy 20111001 |
| Synthesis and antioxidant activity of oxazolyl/thiazolylsulfonylmethyl pyrazoles and isoxazoles. | European journal of medicinal chemistry 20111001 |
| Comparing the influence of dopamine D₂ polymorphisms and plasma drug concentrations on the clinical response to risperidone. | Journal of clinical psychopharmacology 20111001 |
| Enantioselective fungal biotransformation of risperidone in liquid culture medium by capillary electrophoresis and hollow fiber liquid-phase microextraction. | Electrophoresis 20111001 |
| Dosing and switching strategies for paliperidone palmitate: based on population pharmacokinetic modelling and clinical trial data. | CNS drugs 20111001 |
| Biological perspectives: update on newer antipsychotic drugs: are they evidence based? | Perspectives in psychiatric care 20111001 |
| Leflunomide in clinical practice. A retrospective observational study on use of leflunomide in New Zealand. | International journal of rheumatic diseases 20111001 |
| [Analgesic effect of COX inhibitors and its mechanism in a rat model of neuropathic pain]. | Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20111001 |
| Paliperidone palmitate in a child with autistic disorder. | Journal of child and adolescent psychopharmacology 20111001 |
| 5-Methyl-1,2-oxazole-3-carb-oxy-lic acid. | Acta crystallographica. Section E, Structure reports online 20111001 |
| DNA binding, antiviral activities and cytotoxicity of new furochromone and benzofuran derivatives. | Archives of pharmacal research 20111001 |
| Changes in cotherapies after initiation of disease-modifying antirheumatic drug therapy in patients with rheumatoid arthritis. | Arthritis care & research 20111001 |
| Pain control in laparoscopic gynecologic surgery with/without preoperative (preemptive) parecoxib sodium injection: a randomized study. | Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20111001 |
| [Inhibitory activity of dioxy-pyrrolino [3', 4'-d]isoxazoline derivatives containing (1', 2'-O-cyclohexylidendioxyethyl) against Cdc25A and CD45]. | Yao xue xue bao = Acta pharmaceutica Sinica 20111001 |
| Farnesoid X receptor inhibits tamoxifen-resistant MCF-7 breast cancer cell growth through downregulation of HER2 expression. | Oncogene 20110929 |
| Single-channel and structural foundations of neuronal α7 acetylcholine receptor potentiation. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20110928 |
| Application of Hansen solubility parameters for understanding and prediction of drug distribution in microspheres. | International journal of pharmaceutics 20110915 |
| Multiresidue method for the determination of 13 pesticides in three environmental matrices: water, sediments and fish muscle. | Talanta 20110915 |
| Synthesis and biological activity of a novel class nicotinic acetylcholine receptors (nAChRs) ligands structurally related to anatoxin-a. | Bioorganic & medicinal chemistry letters 20110915 |
| Triazole-containing isothiazolidine 1,1-dioxide library synthesis: one-pot, multi-component protocols for small molecular probe discovery. | ACS combinatorial science 20110912 |
| Effects of risperidone and paliperidone pre-treatment on locomotor response following prenatal immune activation. | Journal of psychiatric research 20110901 |
| Influence of ABCB1 genetic polymorphisms on the pharmacokinetics of risperidone in healthy subjects with CYP2D6*10/*10. | British journal of pharmacology 20110901 |
| A role for macrophage migration inhibitory factor in protective immunity against Aspergillus fumigatus. | Immunobiology 20110901 |
| Comparative trial of low- and high-dose zonisamide as monotherapy for childhood epilepsy. | Seizure 20110901 |
| The long-term retention of zonisamide in a large cohort of people with epilepsy at a tertiary referral centre. | Epilepsy research 20110901 |
| Reduced postsynaptic GABAA receptor number and enhanced gaboxadol induced change in holding currents in Purkinje cells of the dystrophin-deficient mdx mouse. | Neurobiology of disease 20110901 |
| Investigation into the regiochemistry of some isoxazoles derived from 1,3-dipolar cycloaddition of 4-nitrobenzonitrile oxide with some dipolarophiles: a combined theoretical and experimental studies. | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20110901 |
| Efficacy of iloperidone in schizophrenia: a PANSS five-factor analysis. | Schizophrenia research 20110901 |
| Neurotoxicity induced by okadaic acid in the human neuroblastoma SH-SY5Y line can be differentially prevented by α7 and β2* nicotinic stimulation. | Toxicological sciences : an official journal of the Society of Toxicology 20110901 |
| Simultaneous detection and quantification of parecoxib and valdecoxib in canine plasma by HPLC with spectrofluorimetric detection: development and validation of a new methodology. | Analytical and bioanalytical chemistry 20110901 |
| Tertiary amides with a five-membered heteroaromatic ring as new probes for the translocator protein. | European journal of medicinal chemistry 20110901 |
| Controversy of non-steroidal anti-inflammatory drugs and intracranial surgery: et ne nos inducas in tentationem? | British journal of anaesthesia 20110901 |
| Effect of intravenous parecoxib on post-craniotomy pain. | British journal of anaesthesia 20110901 |
| Quality of life in patients with partial-onset seizures under adjunctive therapy with zonisamide: results from a prospective non-interventional surveillance study. | Epileptic disorders : international epilepsy journal with videotape 20110901 |
| Case of drug rash with eosinophilia and systemic symptoms induced by zonisamide and reactivation of human herpes virus 7. | The Journal of dermatology 20110901 |
| Bis[N-cyclohexyl-1-(2-{1-[(cyclohexyl-amino)carbonyl]cyclohexyl}-3,5-dioxo-1,2-oxazolidin-4-yl)cyclopentanecarbox-amide] monohydrate. | Acta crystallographica. Section E, Structure reports online 20110901 |
| 2-{Hy-droxy[1-(4-meth-oxy-phen-yl)-4-oxo-3-phenyl-azetidin-2-yl]meth-yl}acrylonitrile. | Acta crystallographica. Section E, Structure reports online 20110901 |
| Dual inhibition of epidermal growth factor and insulin-like 1 growth factor receptors reduce intestinal adenoma burden in the Apc(min/+) mouse. | British journal of cancer 20110823 |
| Effect of paliperidone and risperidone on extracellular glutamate in the prefrontal cortex of rats exposed to prenatal immune activation or MK-801. | Neuroscience letters 20110818 |
| Synthesis of tri- or tetrasubstituted pyrimidine derivatives through the [5+1] annulation of enamidines with either N,N-dimethylformamide dialkyl acetals or orthoesters and their application in a ring transformation of pyrimidines to pyrido[2,3-d]pyrimidin-5-one derivatives. | Chemistry (Weinheim an der Bergstrasse, Germany) 20110816 |
| Chemical and toxicological evolution of the antibiotic sulfamethoxazole under ozone treatment in water solution. | Journal of hazardous materials 20110815 |
| Isoxazole substituted chromans against oxidative stress-induced neuronal damage. | Bioorganic & medicinal chemistry 20110815 |
| Facile synthesis of carbohydrate-integrated isoxazolines through tandem [4+1] cycloaddition and rearrangement of 2-nitroglycals. | Chemical communications (Cambridge, England) 20110814 |
| Leflunomide or methotrexate? Comparison of clinical efficacy and safety in low socio-economic rheumatoid arthritis patients. | Modern rheumatology 20110801 |
| The interaction of antipsychotic drugs with lipids and subsequent lipid reorganization investigated using biophysical methods. | Biochimica et biophysica acta 20110801 |
| Hepatic cytochrome P450s attenuate the cytotoxicity induced by leflunomide and its active metabolite A77 1726 in primary cultured rat hepatocytes. | Toxicological sciences : an official journal of the Society of Toxicology 20110801 |
| Farnesoid X receptor activation by chenodeoxycholic acid induces detoxifying enzymes through AMP-activated protein kinase and extracellular signal-regulated kinase 1/2-mediated phosphorylation of CCAAT/enhancer binding protein β. | Drug metabolism and disposition: the biological fate of chemicals 20110801 |
| Protective effects of COX-2 inhibitor on titanium-particle-induced inflammatory osteolysis via the down-regulation of RANK/RANKL. | Acta biomaterialia 20110801 |
| Isoxazol-5(4H)one derivatives as PTP1B inhibitors showing an anti-obesity effect. | Chemistry, an Asian journal 20110801 |
| Oxime-based click chemistry in the development of 3-isoxazolecarboxylic acid containing inhibitors of Yersinia pestis protein tyrosine phosphatase, YopH. | ChemMedChem 20110801 |
| Changes in schizophrenia-related hospitalization and ER use among patients receiving paliperidone palmitate: results from a clinical trial with a 52-week open-label extension (OLE). | Current medical research and opinion 20110801 |
| Antimycobacterial activity: synthesis of novel 3-(substituted phenyl)-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]isoxazole analogues. | Journal of enzyme inhibition and medicinal chemistry 20110801 |
| Direct electron transfer enhancement of covalently bound tyrosinase to glassy carbon via Woodward's reagent K. | Bioelectrochemistry (Amsterdam, Netherlands) 20110801 |
| Osmotic-controlled release oral delivery system (OROS) paliperidone-related pruritic rash. | Journal of clinical psychopharmacology 20110801 |
| Discovery of potent, soluble and orally active TRPV1 antagonists. Structure-activity relationships of a series of isoxazoles. | Bioorganic & medicinal chemistry letters 20110801 |
| Photodistributed eruption with rhabdomyolisis due to leflunomide. | Photodermatology, photoimmunology & photomedicine 20110801 |
| A case of eczematous and vesicular dermatitis during anti-TNFalpha therapy for rheumatoid arthritis. | Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia 20110801 |
| 3,5-Bis(4-meth-oxy-phen-yl)-4,5-dihydro-isoxazole. | Acta crystallographica. Section E, Structure reports online 20110801 |
| Methyl 3-(4-isopropyl-phen-yl)-1-phenyl-3,3a,4,9b-tetra-hydro-1H-chromeno[4,3-c]isoxazole-3a-carboxyl-ate. | Acta crystallographica. Section E, Structure reports online 20110801 |
| Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure. | The Journal of biological chemistry 20110729 |
| Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes. | Journal of medicinal chemistry 20110714 |
| Preconditioning of intravenous parecoxib attenuates focal cerebral ischemia/reperfusion injury in rats. | Chinese medical journal 20110705 |
| Recurrent pneumothorax associated with pulmonary nodules after leflunomide therapy in rheumatoid arthritis: a case report and review of the literature. | Rheumatology international 20110701 |
| Treatment strategies aiming at remission in early rheumatoid arthritis patients: starting with methotrexate monotherapy is cost-effective. | Rheumatology (Oxford, England) 20110701 |
| Paliperidone overdose with delayed onset of toxicity. | Annals of emergency medicine 20110701 |
| Leflunomide-induced interstitial pneumonitis might be a representative of disease-modifying antirheumatic drug-induced lung injury. | Expert opinion on drug safety 20110701 |
| Drug reaction with eosinophilia and systemic symptoms and severe involvement of digestive tract: description of two cases. | The British journal of dermatology 20110701 |
| Selective GABA transporter inhibitors tiagabine and EF1502 exhibit mechanistic differences in their ability to modulate the ataxia and anticonvulsant action of the extrasynaptic GABA(A) receptor agonist gaboxadol. | The Journal of pharmacology and experimental therapeutics 20110701 |
| Antitumor activity of NVP-AUY922, a novel heat shock protein 90 inhibitor, in human gastric cancer cells is mediated through proteasomal degradation of client proteins. | Cancer science 20110701 |
| MultiSimplex optimization of chromatographic separation and dansyl derivatization conditions in the ultra performance liquid chromatography-tandem mass spectrometry analysis of risperidone, 9-hydroxyrisperidone, monoamine and amino acid neurotransmitters in human urine. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110701 |
| Effects of early long-term treatment with antiepileptic drugs on development of seizures and depressive-like behavior in a rat genetic absence epilepsy model. | Epilepsia 20110701 |
| Phenyl isoxazole voltage-gated sodium channel blockers: structure and activity relationship. | Bioorganic & medicinal chemistry letters 20110701 |
| Drug safety evaluation of zonisamide for the treatment of epilepsy. | Expert opinion on drug safety 20110701 |
| 5-(3-Methyl-phen-yl)-3-phenyl-1,2-oxazole. | Acta crystallographica. Section E, Structure reports online 20110701 |
| 1-Methyl-3-p-tolyl-3,3a,4,9b-tetra-hydro-1H-chromeno[4,3-c]isoxazole-3a-carbonitrile. | Acta crystallographica. Section E, Structure reports online 20110701 |
| 3'-(4-Meth-oxy-phen-yl)-4'-phenyl-3H,4'H-spiro-[1-benzothio-phene-2,5'-isoxazol]-3-one. | Acta crystallographica. Section E, Structure reports online 20110701 |
| 4-tert-Butyl-3',4'-bis-(4-methyl-phen-yl)-3,4-dihydro-1H,4'H-spiro-[naphthalene-2,5'-[1,2]oxazol]-1-one. | Acta crystallographica. Section E, Structure reports online 20110701 |
| Glutathione is a physiologic reservoir of neuronal glutamate. | Biochemical and biophysical research communications 20110617 |
| Self-assembly and gelation behavior of tris(phenylisoxazolyl)benzenes. | The Journal of organic chemistry 20110617 |
| Combined effects of novel heat shock protein 90 inhibitor NVP-AUY922 and nilotinib in a random mutagenesis screen. | Oncogene 20110616 |
| Synthesis and evaluation of antioxidant and antibacterial activities of new substituted bis(1,3,4-oxadiazoles), 3,5-bis(substituted) pyrazoles and isoxazoles. | Bioorganic & medicinal chemistry letters 20110615 |
| New FAAH inhibitors based on 3-carboxamido-5-aryl-isoxazole scaffold that protect against experimental colitis. | Bioorganic & medicinal chemistry 20110615 |
| Base-catalyzed reactions of environmentally relevant N-chloro-piperidines. A quantum-chemical study. | Organic & biomolecular chemistry 20110607 |
| Novel chemo-sensitizing agent, ERW1227B, impairs cellular motility and enhances cell death in glioblastomas. | Journal of neuro-oncology 20110601 |
| Intraoperative infusion of S(+)-ketamine enhances post-thoracotomy pain control compared with perioperative parecoxib when used in conjunction with thoracic paravertebral ropivacaine infusion. | Journal of cardiothoracic and vascular anesthesia 20110601 |
| The 4-aminopyridine in vitro epilepsy model analyzed with a perforated multi-electrode array. | Neuropharmacology 20110601 |
| Sex-specificity of associative learning-induced changes in GABAergic tonic inhibition in layer 4 neurons of mouse barrel cortex. | Behavioural brain research 20110601 |
| Efficient in silico assay of inhibitors of hepatitis C Virus RNA-dependent RNA polymerase by structure-based virtual screening and in vitro evaluation. | Assay and drug development technologies 20110601 |
| Effective treatment of Kimura's disease with leflunomide in combination with glucocorticoids. | Clinical rheumatology 20110601 |
| Targeting oxidative stress, mitochondrial dysfunction and neuroinflammatory signaling by selective cyclooxygenase (COX)-2 inhibitors mitigates MPTP-induced neurotoxicity in mice. | Progress in neuro-psychopharmacology & biological psychiatry 20110601 |
| A comparative study of paliperidone palmitate and risperidone long-acting injectable therapy in schizophrenia. | Progress in neuro-psychopharmacology & biological psychiatry 20110601 |
| Effects of intramuscular parecoxib administration on vasospasm in an experimental subarachnoid hemorrhage model. | The International journal of neuroscience 20110601 |
| Prolongation of cardiac ventricular repolarization under paliperidone: how and how much? | Journal of cardiovascular pharmacology 20110601 |
| Effects of COX inhibition on experimental pain and hyperalgesia during and after remifentanil infusion in humans. | Pain 20110601 |
| Pharmacological enhancement of δ-subunit-containing GABA(A) receptors that generate a tonic inhibitory conductance in spinal neurons attenuates acute nociception in mice. | Pain 20110601 |
| Risperidone in schizophrenia: is there a role for therapeutic drug monitoring? | Therapeutic drug monitoring 20110601 |
| Differential effects of antipsychotic medications on polyunsaturated fatty acid biosynthesis in rats: Relationship with liver delta6-desaturase expression. | Schizophrenia research 20110601 |
| Deletion of the betaine-GABA transporter (BGT1; slc6a12) gene does not affect seizure thresholds of adult mice. | Epilepsy research 20110601 |
| Synthesis and in vitro antimicrobial activities of new (cyano-NNO-azoxy)pyrazole derivatives. | Bioorganic & medicinal chemistry letters 20110601 |
| Paliperidone-related rabbit syndrome. | Journal of clinical psychopharmacology 20110601 |
| Use of paliperidone in elderly patients with schizophrenia and schizoaffective disorder: a prospective open-label short-term pilot study. | Journal of clinical psychopharmacology 20110601 |
| Microbially mediated abiotic transformation of the antimicrobial agent sulfamethoxazole under iron-reducing soil conditions. | Environmental science & technology 20110601 |
| Oral paliperidone: a review of its use in the management of schizoaffective disorder. | CNS drugs 20110601 |
| [Pharmacological properties of paliperidone ER (INVEGA(®)) and results of its clinical studies]. | Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20110601 |
| [Recommendations on the management of psoriatic arthritis]. | Annales de dermatologie et de venereologie 20110601 |
| Poly[(μ(3)-rac-5-eth-oxy-carbonyl-6-hy-droxy-6-methyl-4-phenyl-4,5,6,7-tetra-hydro-benzo[c]isoxazol-3-olato)potassium]. | Acta crystallographica. Section E, Structure reports online 20110601 |
| 3-Allyl-1-{[3-(4-nitro-phen-yl)-4,5-dihydro-1,3-oxazol-5-yl]meth-yl}-1H-anthra[1,2-d]imidazole-2,6,11(3H)-trione. | Acta crystallographica. Section E, Structure reports online 20110601 |
| Cascade formation of isoxazoles: facile base-mediated rearrangement of substituted oxetanes. | Angewandte Chemie (International ed. in English) 20110527 |
| Novel mechanism of inhibition of human angiotensin-I-converting enzyme (ACE) by a highly specific phosphinic tripeptide. | The Biochemical journal 20110515 |
| Biological evaluation of novel benzisoxazole derivatives as PPARδ agonists. | Bioorganic & medicinal chemistry 20110515 |
| Design, synthesis, and insecticidal evaluation of new benzoylureas containing isoxazoline and isoxazole group. | Journal of agricultural and food chemistry 20110511 |
| Palladium-catalyzed cyanomethylation of aryl halides through domino Suzuki coupling-isoxazole fragmentation. | Journal of the American Chemical Society 20110511 |
| Iodocyclization of hydroxylamine derivatives based on the control of oxidative aromatization leading to 2,5-dihydroisoxazoles and isoxazoles. | The Journal of organic chemistry 20110506 |
| Design, synthesis, and pharmacological characterization of novel spirocyclic quinuclidinyl-Δ2-isoxazoline derivatives as potent and selective agonists of α7 nicotinic acetylcholine receptors. | ChemMedChem 20110502 |
| A 52-week open-label study of the safety and tolerability of paliperidone palmitate in patients with schizophrenia. | Journal of psychopharmacology (Oxford, England) 20110501 |
| Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors. | Pharmacogenetics and genomics 20110501 |
| Design, synthesis and cytotoxicity of a new series of isoxazolidine based nucleoside analogues. | Archiv der Pharmazie 20110501 |
| Preclinical discovery of apixaban, a direct and orally bioavailable factor Xa inhibitor. | Journal of thrombosis and thrombolysis 20110501 |
| Metabolism of the c-Fos/activator protein-1 inhibitor T-5224 by multiple human UDP-glucuronosyltransferase isoforms. | Drug metabolism and disposition: the biological fate of chemicals 20110501 |
| Role of macrophage migration inhibitory factor in primary glioblastoma multiforme cells. | Journal of neuroscience research 20110501 |
| Methotrexate versus leflunomide in rheumatoid arthritis: what is new in 2011? | Current opinion in rheumatology 20110501 |
| Pyrazolo[3,4-c]isothiazole and isothiazolo[4,3-d]isoxazole derivatives as antifungal agents. | Pharmaceutical biology 20110501 |
| Update 2011: leflunomide in rheumatoid arthritis - strengths and weaknesses. | Current opinion in rheumatology 20110501 |
| Moderate toxic effects following acute zonisamide overdose. | Epilepsy & behavior : E&B 20110501 |
| Binding of 2-[18F]fluoro-CP-118,954 to mouse acetylcholinesterase: microPET and ex vivo Cerenkov luminescence imaging studies. | Nuclear medicine and biology 20110501 |
| Leflunomide in renal transplantation. | Expert review of clinical immunology 20110501 |
| Crystal structures of T. b. rhodesiense adenosine kinase complexed with inhibitor and activator: implications for catalysis and hyperactivation. | PLoS neglected tropical diseases 20110501 |
| (S)-[5-Methyl-3-(3-methyl-thio-phen-2-yl)-4,5-dihydro-isoxazol-5-yl]methanol. | Acta crystallographica. Section E, Structure reports online 20110501 |
| [Isolation and identification of brominated alkaloids from the sponge Ircinia sp]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110501 |
| Ammonia channeling in Plasmodium falciparum GMP synthetase: investigation by NMR spectroscopy and biochemical assays. | Biochemistry 20110426 |
| Catalytic asymmetric syntheses of isoxazoline-N-oxides under phase-transfer conditions. | Chemical communications (Cambridge, England) 20110421 |
| Design, synthesis, and evaluation of small molecule Hsp90 probes. | Bioorganic & medicinal chemistry 20110415 |
| Zonisamide-induced long-lasting recovery of dopaminergic neurons from MPTP-toxicity. | Brain research 20110412 |
| Pseudo-pseudo Meigs syndrome developed under the leflunomide therapy. | Rheumatology international 20110401 |
| Hippocampal GABAergic dysfunction in a rat chronic mild stress model of depression. | Hippocampus 20110401 |
| Zonisamide-related erectile dysfunction. | The journal of sexual medicine 20110401 |
| A comparison of an interferon-gamma release assay and tuberculin skin test in refractory inflammatory disease patients screened for latent tuberculosis prior to the initiation of a first tumor necrosis factor α inhibitor. | Clinical rheumatology 20110401 |
| Efficacy of zonisamide in a case of Parkinson's disease with intractable resting and re-emergent tremor. | European journal of neurology 20110401 |
| Interstitial lung diseases after leflunomide use in nephropathy: an analysis of reported cases in Chinese literature. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20110401 |
| Synthesis of some novel androstanes as potential aromatase inhibitors. | Steroids 20110401 |
| Prevention of post-cardiopulmonary bypass acute kidney injury by endothelin A receptor blockade. | Critical care medicine 20110401 |
| TNF-α potentiates lysophosphatidic acid-induced COX-2 expression via PKD in human colonic myofibroblasts. | American journal of physiology. Gastrointestinal and liver physiology 20110401 |
| Determination of clomazone residues in soybean and soil by high performance liquid chromatography with DAD detection. | Bulletin of environmental contamination and toxicology 20110401 |
| Design, synthesis and cytotoxicity of a new series of isoxazolidines derived from substituted chalcones. | European journal of medicinal chemistry 20110401 |
| Selective endothelin-A receptor antagonism reduces proteinuria, blood pressure, and arterial stiffness in chronic proteinuric kidney disease. | Hypertension (Dallas, Tex. : 1979) 20110401 |
| Paliperidone augmentation for treatment-resistant depression: a case report. | Journal of clinical psychopharmacology 20110401 |
| Paliperidone-associated seizure after discontinuation of sodium valproate: a case report. | Journal of clinical psychopharmacology 20110401 |
| Small-molecule blocks malignant astrocyte proliferation and induces neuronal gene expression. | Differentiation; research in biological diversity 20110401 |
| Update on newer antipsychotic drugs. | Journal of psychosocial nursing and mental health services 20110401 |
| Successful treatment of portopulmonary hypertension with the selective endothelin receptor antagonist Sitaxentan. | Wiener klinische Wochenschrift 20110401 |
| Zonisamide toxicity in a patient with an intentional overdose. | The Annals of pharmacotherapy 20110401 |
| Predictors of risperidone and 9-hydroxyrisperidone serum concentration in children and adolescents. | Journal of child and adolescent psychopharmacology 20110401 |
| Intensive polyoma virus nephropathy treatment as a preferable approach for graft surveillance. | Transplantation proceedings 20110401 |
| Antitumor effect of novel HSP90 inhibitor NVP-AUY922 against oral squamous cell carcinoma. | Anticancer research 20110401 |
| Risk of arrest in persons with schizophrenia and bipolar disorder in a Florida Medicaid program: the role of atypical antipsychotics, conventional neuroleptics, and routine outpatient behavioral health services. | The Journal of clinical psychiatry 20110401 |
| 3-(3-Chloro-phen-yl)-1-methyl-3,3a,4,9b-tetra-hydro-1H-chromeno[4,3-c]isoxazole-3a-carbonitrile. | Acta crystallographica. Section E, Structure reports online 20110401 |
| 1-Methyl-3-(2-methyl-phen-yl)-3,3a,4,9b-tetra-hydro-1H-chromeno[4,3-c][1,2]oxazole-3a-carbonitrile. | Acta crystallographica. Section E, Structure reports online 20110401 |
| 1-Methyl-3-(naphthalen-1-yl)-3,3a,4,9b-tetra-hydro-1H-chromeno[4,3-c]isoxazole-3a-carbonitrile. | Acta crystallographica. Section E, Structure reports online 20110401 |
| Paliperidone-associated atypical neuroleptic malignant syndrome: a case report. | Progress in neuro-psychopharmacology & biological psychiatry 20110330 |
| Our clinical experience with zonisamide in resistant generalized epilepsy syndromes. | Ideggyogyaszati szemle 20110330 |
| Glutamate reduces experimental intestinal hyperpermeability and facilitates glutamine support of gut integrity. | World journal of gastroenterology 20110328 |
| New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress. | Journal of natural products 20110325 |
| DHODH modulates transcriptional elongation in the neural crest and melanoma. | Nature 20110324 |
| Synthesis and pro-apoptotic activity of novel glycyrrhetinic acid derivatives. | Chembiochem : a European journal of chemical biology 20110321 |
| [Inhibition of leflunomide active metabolite A771726 on high glucose-induced podocyte apoptosis]. | Zhonghua yi xue za zhi 20110315 |
| Synthesis and antimicrobial evaluation of some heterocyclic chalcone derivatives. | Molecules (Basel, Switzerland) 20110309 |
| Rituximab and leflunomide for Wegener's granulomatosis: a long-term follow-up. | Rheumatology international 20110301 |
| Effect of environmental factors on the biosynthesis of the neuro-excitatory amino acid β-ODAP (β-N-oxalyl-L-α,β-diaminopropionic acid) in callus tissue of Lathyrus sativus. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20110301 |
| Paliperidone extended-release as adjunctive therapy to lithium or valproate in the treatment of acute mania: a randomized, placebo-controlled study. | Journal of affective disorders 20110301 |
| Extrasynaptic GABAA receptor activation reverses recognition memory deficits in an animal model of schizophrenia. | Psychopharmacology 20110301 |
| A case of SUNCT syndrome responsive to zonisamide. | Cephalalgia : an international journal of headache 20110301 |
| Value of the small cohort study including a physical examination for minor structural defects in identifying new human teratogens. | Congenital anomalies 20110301 |
| Overexpression of cholesterol 7α-hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasis. | Hepatology (Baltimore, Md.) 20110301 |
| [Role of daptomycin in the empirical and directed therapy of infections caused by Gram-positive bacteria in the critically ill patient]. | Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia 20110301 |
| Iloperidone, asenapine, and lurasidone: a brief overview of 3 new second-generation antipsychotics. | Postgraduate medicine 20110301 |
| (E)-7-(4-Chloro-phen-yl)-5,7-dihydro-4H-pyrano[3,4-c]isoxazole-3-carbaldehyde oxime. | Acta crystallographica. Section E, Structure reports online 20110301 |
| Iloperidone for the management of adults with schizophrenia. | Clinical therapeutics 20110301 |
| Photochemistry and vibrational spectra of matrix-isolated methyl 4-chloro-5-phenylisoxazole-3-carboxylate. | The journal of physical chemistry. A 20110224 |
| Heterogeneity of Escherichia coli population by respiratory activity and membrane potential of cells during growth and long-term starvation. | Microbiological research 20110220 |
| Conformationally constrained farnesoid X receptor (FXR) agonists: heteroaryl replacements of the naphthalene. | Bioorganic & medicinal chemistry letters 20110215 |
| Iloperidone: Does it have a meaningful place in therapy? | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20110215 |
| Iloperidone: A new drug for the treatment of schizophrenia. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20110215 |
| Zonisamide for bipolar disorder, mania or mixed states: a randomized, double blind, placebo-controlled adjunctive trial. | Psychopharmacology bulletin 20110215 |
| Preparation and evaluation of biodegradable films containing the potent osteogenic compound BFB0261 for localized delivery. | International journal of pharmaceutics 20110214 |
| Gaboxadol has affinity for the proton-coupled amino acid transporter 1, SLC36A1 (hPAT1)--A modelling approach to determine IC(50) values of the three ionic species of gaboxadol. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20110214 |
| Interactions of monoamine oxidases with the antiepileptic drug zonisamide: specificity of inhibition and structure of the human monoamine oxidase B complex. | Journal of medicinal chemistry 20110210 |
| Excited-state intramolecular proton transfer in hydroxyoxime-based chemical sensors. | The journal of physical chemistry. A 20110210 |
| Discovery, synthesis, and biological evaluation of a novel group of selective inhibitors of filoviral entry. | Journal of medicinal chemistry 20110210 |
| Highly enantioselective nitrone cycloadditions with 2-alkenoyl pyridine N-oxides catalyzed by Cu(II)-BOX complexes. | Organic letters 20110204 |
| Metal-free sequential [3 + 2]-dipolar cycloadditions using cyclooctynes and 1,3-dipoles of different reactivity. | Journal of the American Chemical Society 20110202 |
| Jessner-Kanof disease induced by leflunomide: a dermal variant of cutaneous lupus? | Rheumatology international 20110201 |
| A randomized controlled trial of valdecoxib and glyceryl trinitrate for the prevention of post-ERCP pancreatitis. | Journal of clinical gastroenterology 20110201 |
| Selective cyclooxygenase-2 (COX-2) inhibitors and breast cancer risk. | Breast (Edinburgh, Scotland) 20110201 |
| Efficacy of intravenous paracetamol compared to dipyrone and parecoxib for postoperative pain management after minor-to-intermediate surgery: a randomised, double-blind trial. | European journal of anaesthesiology 20110201 |
| A pilot open-label trial of zonisamide in Unverricht-Lundborg disease. | Movement disorders : official journal of the Movement Disorder Society 20110201 |
| Parecoxib sodium in the treatment of postoperative pain after Lichtenstein tension-free mesh inguinal hernia repair. | Hernia : the journal of hernias and abdominal wall surgery 20110201 |
| Effect of ABCG2 genotypes on the pharmacokinetics of A771726, an active metabolite of prodrug leflunomide, and association of A771726 exposure with serum uric acid level. | European journal of clinical pharmacology 20110201 |
| Elucidation of a novel bioactivation pathway of a 3,4-unsubstituted isoxazole in human liver microsomes: formation of a glutathione adduct of a cyanoacrolein derivative after isoxazole ring opening. | Drug metabolism and disposition: the biological fate of chemicals 20110201 |
| Are the long-acting intramuscular formulations of risperidone or paliperidone palmitate associated with post-injection delirium/sedation syndrome? An assessment of safety databases. | Current drug safety 20110201 |
| Change in employment status over 52 weeks in patients with schizophrenia: an observational study. | Current medical research and opinion 20110201 |
| Endothelin receptor antagonists as disease modifiers in systemic sclerosis. | Inflammation & allergy drug targets 20110201 |
| Synthesis and biological evaluation of 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydroquinazolinone hybrids as anticancer agents. | European journal of medicinal chemistry 20110201 |
| Synthesis of elastin based peptides conjugated to benzisoxazole as a new class of potent antimicrobials--A novel approach to enhance biocompatibility. | European journal of medicinal chemistry 20110201 |
| Biological evaluation of KRIBB3 analogs as a microtubule polymerization inhibitor. | Bioorganic & medicinal chemistry letters 20110201 |
| Synthesis of new isoxazoline-based acidic amino acids and investigation of their affinity and selectivity profile at ionotropic glutamate receptors. | European journal of medicinal chemistry 20110201 |
| Structure-activity studies of a novel series of isoxazole-3-carboxamide derivatives as TRPV1 antagonists. | Bioorganic & medicinal chemistry letters 20110201 |
| Prolapse gastropathy. | Journal of pediatric gastroenterology and nutrition 20110201 |
| Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome with review of the relevant published work. | The Journal of dermatology 20110201 |
| Sitaxentan-related acute liver failure in a patient with pulmonary arterial hypertension. | The European respiratory journal 20110201 |
| Liver toxicity of sitaxentan in pulmonary arterial hypertension. | The European respiratory journal 20110201 |
| Zonisamide for migraine prophylaxis in topiramate-intolerant patients: an observational study. | Headache 20110201 |
| Effects of Cox inhibitors on bone and tendon healing. | Acta orthopaedica. Supplementum 20110201 |
| Leflunomide in Pakistani patients with rheumatoid arthritis: prospective study in daily rheumatology practice. | International journal of rheumatic diseases 20110201 |
| [Effects of parecoxib on morphine dosage in postoperative patient-controlled analgesia following thoracoscope-assisted thoracotomy]. | Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20110201 |
| A novel hypothesized clinical implication of zonisamide for autism. | Annals of neurology 20110201 |
| Liver toxicity of sitaxentan in pulmonary arterial hypertension. | European heart journal 20110201 |
| 1-[2-(4-Nitrophenyl)-5-(5-phenyl-1,2-oxazol-3-yl)-1,2,3,4-tetrahydroquinolin-4-yl]pyrrolidin-2-one. | Acta crystallographica. Section E, Structure reports online 20110201 |
| cis-6-Bromo-4-(1-methyl-1H-indol-3-yl)-10,10a-dihydro-1H,4H-2,9-dioxa-3-aza-benz[f]azulene. | Acta crystallographica. Section E, Structure reports online 20110201 |
| Immunosuppressive therapy in children. | Journal of the Indian Medical Association 20110201 |
| Dihydroisoxazole analogs for labeling and visualization of catalytically active transglutaminase 2. | Chemistry & biology 20110128 |
| Synthesis of 4(5)-phenacyl-imidazoles from isoxazole side-chain rearrangements. | Organic & biomolecular chemistry 20110121 |
| Synthesis of isoxazoline N-oxides via [hydroxy(tosyloxy)iodo]benzene (HTIB)-mediated oxidative N-O coupling. | The Journal of organic chemistry 20110121 |
| Paliperidone-induced leukopenia and neutropenia: a case report. | Progress in neuro-psychopharmacology & biological psychiatry 20110115 |
| A double-blind study of paliperidone palmitate and risperidone long-acting injectable in adults with schizophrenia. | Progress in neuro-psychopharmacology & biological psychiatry 20110115 |
| Analysis of risperidone and 9-hydroxyrisperidone in human plasma, urine and saliva by MEPS-LC-UV. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110115 |
| Psammaplysin H, a new antimalarial bromotyrosine alkaloid from a marine sponge of the genus Pseudoceratina. | Bioorganic & medicinal chemistry letters 20110115 |
| Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists. | Journal of medicinal chemistry 20110113 |
| Detection and evaluation of a drug safety signal concerning pancreatic cancer: lessons from a joint approach of three European biologics registers. | Rheumatology (Oxford, England) 20110101 |
| Evaluation of the effect of paliperidone extended release and quetiapine on corrected QT intervals: a randomized, double-blind, placebo-controlled study. | International clinical psychopharmacology 20110101 |
| Transcriptional tools: Small molecules for modulating CBP KIX-dependent transcriptional activators. | Biopolymers 20110101 |
| A series of D-amino acid oxidase inhibitors specifically prevents and reverses formalin-induced tonic pain in rats. | The Journal of pharmacology and experimental therapeutics 20110101 |
| GABAA receptor subtype-selective modulators. II. α5-selective inverse agonists for cognition enhancement. | Current topics in medicinal chemistry 20110101 |
| Parecoxib and its metabolite valdecoxib directly interact with cannabinoid binding sites in CB1-expressing HEK 293 cells and rat brain tissue. | Neurochemistry international 20110101 |
| A small-molecule macrophage migration inhibitory factor antagonist protects against glomerulonephritis in lupus-prone NZB/NZW F1 and MRL/lpr mice. | Journal of immunology (Baltimore, Md. : 1950) 20110101 |
| 1,2,5-Oxadiazole analogues of leflunomide and related compounds. | European journal of medicinal chemistry 20110101 |
| Synthesis of a novel human PPARδ selective agonist and its stimulatory effect on oligodendrocyte differentiation. | Bioorganic & medicinal chemistry letters 20110101 |
| The synthesis and biological evaluation of 2-(3-methyl or 3-phenylisoxazol-5-yl)-3-aryl-8-thiabicyclo[3.2.1]octanes. | Bioorganic & medicinal chemistry letters 20110101 |
| Efficacy and safety of adjunctive zonisamide in adult patients with refractory partial-onset epilepsy: a randomized, double-blind, placebo-controlled trial. | Clinical drug investigation 20110101 |
| The effect of ESR1 and ESR2 gene polymorphisms on the outcome of rheumatoid arthritis treatment with leflunomide. | Pharmacogenomics 20110101 |
| Mitigation of dimethazone residues in soil and runoff water from agricultural field. | Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 20110101 |
| Atypical antipsychotics: the two new arrivals. | Issues in mental health nursing 20110101 |
| Amygdalar glutamatergic neuronal systems play a key role on the hibernating state of hamsters. | BMC neuroscience 20110101 |
| Extrasynaptic GABA(A) receptors and tonic inhibition in rat auditory thalamus. | PloS one 20110101 |
| Paliperidone ER and oral risperidone in patients with schizophrenia: a comparative database analysis. | BMC psychiatry 20110101 |
| Paliperidone-induced neuroleptic malignant syndrome. | The Journal of neuropsychiatry and clinical neurosciences 20110101 |
| Identification and quantification of selected inflammatory genes modulated by leflunomide and prednisone treatment in early rheumatoid arthritis patients. | Clinical and experimental rheumatology 20110101 |
| Cardiac safety of the electroconvulsive therapy-paliperidone combination: a preliminary study. | General hospital psychiatry 20110101 |
| Human dihydroorotate dehydrogenase inhibitors, a novel approach for the treatment of autoimmune and inflammatory diseases. | Arzneimittel-Forschung 20110101 |
| QSAR analysis of [(biphenyloxy)propyl]isoxazoles: agents against coxsackievirus B3. | Future medicinal chemistry 20110101 |
| Photocycloaddition of aromatic and aliphatic aldehydes to isoxazoles: Cycloaddition reactivity and stability studies. | Beilstein journal of organic chemistry 20110101 |
| Paliperidone extended-release: does it have a place in antipsychotic therapy? | Drug design, development and therapy 20110101 |
| Effect of transition from sitaxsentan to ambrisentan in pulmonary arterial hypertension. | Vascular health and risk management 20110101 |
| Efficacy and safety of leflunomide or methotrexate plus subcutaneous tumour necrosis factor-alpha blocking agents in rheumatoid arthritis. | International journal of immunopathology and pharmacology 20110101 |
| Chemopreventive effect of mofezolac on beef tallow diet/azoxymethane-induced colon carcinogenesis in rats. | Hepato-gastroenterology 20110101 |
| Adsorption of isoxaflutole degradates to aluminum and iron hydrous oxides. | Journal of environmental quality 20110101 |
| 1-[2-(4-Nitro-phen-yl)-5-(5-phenyl-1,2-oxazol-3-yl)-1,2,3,4-tetra-hydro-quinolin-4-yl]pyrrolidin-2-one monohydrate. | Acta crystallographica. Section E, Structure reports online 20110101 |
| Inhibition of respiratory syncytial virus in vitro and in vivo by the immunosuppressive agent leflunomide. | Antiviral therapy 20110101 |
| Acute dystonia associated with paliperidone overdose. | Psychosomatics 20110101 |
| Onset of efficacy and tolerability following the initiation dosing of long-acting paliperidone palmitate: post-hoc analyses of a randomized, double-blind clinical trial. | BMC psychiatry 20110101 |
| Liver toxicity is rare in rheumatoid arthritis patients using combination therapy with leflunomide and methotrexate. | Revista brasileira de reumatologia 20110101 |
| Safety of parecoxib in asthmatic patients with aspirin-exacerbated respiratory disease. | International archives of allergy and immunology 20110101 |
| Thrombosis is reduced by inhibition of COX-1, but unaffected by inhibition of COX-2, in an acute model of platelet activation in the mouse. | PloS one 20110101 |
| Soft tissue infections with atypical mycobacteria in two patients with inflammatory rheumatic diseases using TNF-inhibitors and/or leflunomide. | Acta clinica Belgica 20110101 |
| Synthesis and anti-HIV activity of novel 3-substituted phenyl-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]isoxazole analogues. | Acta poloniae pharmaceutica 20110101 |
| Combined 3D-QSAR, molecular docking and molecular dynamics study on derivatives of peptide epoxyketone and tyropeptin-boronic acid as inhibitors against the β5 subunit of human 20S proteasome. | International journal of molecular sciences 20110101 |
| Paliperidone-induced obsessive symptoms. | The Journal of neuropsychiatry and clinical neurosciences 20110101 |
| 3D-QSAR studies on a series of dihydroorotate dehydrogenase inhibitors: analogues of the active metabolite of leflunomide. | International journal of molecular sciences 20110101 |
| Mesomorphic properties of an homologous series of thioalkyl-terminated azomesogens. | International journal of molecular sciences 20110101 |
| The small-molecule TNF-alpha modulator, UTL-5g, reduces side effects induced by cisplatin and enhances the therapeutic effect of cisplatin in vivo. | Journal of experimental therapeutics & oncology 20110101 |
| Therapeutic efficacy of TBC3711 in monocrotaline-induced pulmonary hypertension. | Respiratory research 20110101 |
| The quest for targeted delivery in colon cancer: mucoadhesive valdecoxib microspheres. | International journal of nanomedicine 20110101 |
| Dose pattern and effectiveness of paliperidone extended-release tablets in patients with schizophrenia. | Clinical neuropharmacology 20110101 |
| Zonisamide versus topiramate in migraine prophylaxis: a double-blind randomized clinical trial. | Clinical neuropharmacology 20110101 |
| Risk of hepatotoxicity with add-on leflunomide in rheumatoid arthritis patients. | Arzneimittel-Forschung 20110101 |
| [How does one manage patients with rheumatoid arthritis and positive serology to hepatitis B, hepatitis C, human immunodeficiency virus?]. | Reumatologia clinica 20110101 |
| Novel benzimidazole derivatives as expected anticancer agents. | Acta poloniae pharmaceutica 20110101 |
| Electron ionization and electrospray mass spectra of diaryl-substituted enaminoketones and their thio analogs. | European journal of mass spectrometry (Chichester, England) 20110101 |
| [Novel iodocyclization method based on the controlling of oxidative aromatization]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20110101 |
| Neglected disease - african sleeping sickness: recent synthetic and modeling advances. | Scientia pharmaceutica 20110101 |
| Synthesis of Diarylpyrazoles Containing a Phenylsulphone or Carbonitrile Moiety and their Chalcones as Possible Anti-Inflammatory Agents. | Scientia pharmaceutica 20110101 |
| Current and emerging treatments for uterine myoma - an update. | International journal of women's health 20110101 |
| Improvement of oral dyskinesia after switching from aripiprazole to paliperidone: a case report. | The Journal of neuropsychiatry and clinical neurosciences 20110101 |
| Manic symptoms during a switch from risperidone to paliperidone: a case report. | The Journal of neuropsychiatry and clinical neurosciences 20110101 |
| Interstitial lung disease in rheumatoid arthritis: response to IL-6R blockade. | Scandinavian journal of rheumatology 20110101 |
| Apparent acute idiosyncratic hepatic necrosis associated with zonisamide administration in a dog. | Journal of veterinary internal medicine 20110101 |
| Impact of bile acids on the growth of human cholangiocarcinoma via FXR. | Journal of hematology & oncology 20110101 |
| Efficacy of parecoxib, sumatriptan, and rizatriptan in the treatment of acute migraine attacks. | Clinical neuropharmacology 20110101 |
| Novel treatment options of binge eating disorder. | Current medicinal chemistry 20110101 |
| Renal tubular acidosis associated with zonisamide therapy in a dog. | Journal of veterinary internal medicine 20110101 |
| Differential immediate and sustained memory enhancing effects of alpha7 nicotinic receptor agonists and allosteric modulators in rats. | PloS one 20110101 |
| [Peripheral neuropathy and leflunomide]. | Acta reumatologica portuguesa 20110101 |
| Brominated compounds from marine sponges of the genus Aplysina and a compilation of their 13C NMR spectral data. | Marine drugs 20110101 |
| [Case of schizophrenia in which depressive and negative symptoms relapsed on switching from oral risperidone to risperidone long-acting injection]. | Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica 20110101 |
| Iloperidone: a clinical overview. | The Journal of clinical psychiatry 20110101 |
| Irreversible inhibitors of tissue transglutaminase. | Advances in enzymology and related areas of molecular biology 20110101 |
| Emergence of neuroleptic malignant syndrome while switching between risperidone and paliperidone. | The Journal of neuropsychiatry and clinical neurosciences 20110101 |
| Tardive Tourette-like syndrome in a patient treated with paliperidone. | The Journal of neuropsychiatry and clinical neurosciences 20110101 |
| [Investigation vesicle cycle in nerve formations in somatic muscle of the earthworm Lumbricus terrestris]. | Tsitologiia 20110101 |
| Efficacy and safety of parecoxib in the treatment of acute renal colic: a randomized clinical trial. | International braz j urol : official journal of the Brazilian Society of Urology 20110101 |
| Incidence and clinical implication of nosocomial infections associated with implantable biomaterials - catheters, ventilator-associated pneumonia, urinary tract infections. | GMS Krankenhaushygiene interdisziplinar 20110101 |
| QSAR study and molecular design of open-chain enaminones as anticonvulsant agents. | International journal of molecular sciences 20110101 |
| Disoxaril mutants of Coxsackievirus B1: phenotypic characteristics and analysis of the target VP1 gene. | Zeitschrift fur Naturforschung. C, Journal of biosciences 20110101 |
| [Efficacy and tolerance of rezonizate in complex with fluoroquinolones or mycobutin on a model of experimental murine tuberculosis]. | Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20110101 |
| [New drugs in the treatment of adult patients with refractery epilepsy]. | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20110101 |
| An unusual case of DRESS syndrome due to leflunomide. | BMJ case reports 20110101 |
| Anti-BK virus mechanisms of sirolimus and leflunomide alone and in combination: toward a new therapy for BK virus infection. | Transplantation 20101227 |
| Inhibition of sphingosine 1-phosphate lyase for the treatment of rheumatoid arthritis: discovery of (E)-1-(4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone oxime (LX2931) and (1R,2S,3R)-1-(2-(isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol (LX2932). | Journal of medicinal chemistry 20101223 |
| Degradation of the herbicides clomazone, paraquat, and glyphosate by thermally activated peroxydisulfate. | Journal of agricultural and food chemistry 20101222 |
| Tethered agonist analogs as site-specific probes for domains of the human α7 nicotinic acetylcholine receptor that differentially regulate activation and desensitization. | Molecular pharmacology 20101201 |
| Clozapine and other competitive antagonists reactivate risperidone-inactivated h5-HT7 receptors: radioligand binding and functional evidence for GPCR homodimer protomer interactions. | Psychopharmacology 20101201 |
| Synthesis of novel chiral Δ2-isoxazoline derivatives related to ABT-418 and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes. | European journal of medicinal chemistry 20101201 |
| A real-time screening assay for GIRK1/4 channel blockers. | Journal of biomolecular screening 20101201 |
| Zonisamide suppresses the tonic phase but not the clonic phase of generalized seizures in developing rats. | Epilepsy research 20101201 |
| Clinical laboratory measurement of direct factor Xa inhibitors: anti-Xa assay is preferable to prothrombin time assay. | Thrombosis and haemostasis 20101201 |
| Iloperidone: chemistry, pharmacodynamics, pharmacokinetics and metabolism, clinical efficacy, safety and tolerability, regulatory affairs, and an opinion. | Expert opinion on drug metabolism & toxicology 20101201 |
| Effect of cyamemazine on the steady-state plasma concentrations of risperidone and 9-hydroxyrisperidone: a preliminary retrospective study. | Therapeutic drug monitoring 20101201 |
| Association of 9-hydroxy risperidone concentrations with risk of switching or discontinuation in the clinical antipsychotic trial of intervention effectiveness-Alzheimer's disease trial. | Journal of clinical psychopharmacology 20101201 |
| Comparison of the efficacy of parecoxib versus ketorolac combined with morphine on patient-controlled analgesia for post-cesarean delivery pain management. | Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists 20101201 |
| The biological targets of acivicin inspired 3-chloro- and 3-bromodihydroisoxazole scaffolds. | Chemical communications (Cambridge, England) 20101128 |
| Expanding stereochemical and skeletal diversity using petasis reactions and 1,3-dipolar cycloadditions. | Organic letters 20101119 |
| Bioactivation of isothiazoles: minimizing the risk of potential toxicity in drug discovery. | Chemical research in toxicology 20101115 |
| Synthesis of 3-aryl/benzyl-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole derivatives: a comparison between conventional, microwave-assisted and flow-based methodologies. | The Journal of organic chemistry 20101105 |
| Synthesis of dihydrobenzisoxazoles by the [3 + 2] cycloaddition of arynes and oxaziridines. | The Journal of organic chemistry 20101105 |
| Mechanism of K(v)2.1 channel inhibition by a selective COX-2 inhibitor SC-791-modification of gating. | Brain research 20101104 |
| Sex differences and the effect of gaboxadol and zolpidem on EEG power spectra in NREM and REM sleep. | Journal of psychopharmacology (Oxford, England) 20101101 |
| The neurosteroid dehydroepiandrosterone (DHEA) and its metabolites alter 5-HT neuronal activity via modulation of GABAA receptors. | Journal of psychopharmacology (Oxford, England) 20101101 |
| Antagonism of macrophage migration inhibitory factor decreases cyclophosphamide cystitis in mice. | Neurourology and urodynamics 20101101 |
| Stimulatory actions of lysophosphatidic acid on mouse ATDC5 chondroprogenitor cells. | Journal of bone and mineral metabolism 20101101 |
| Survivin is regulated by interleukin-4 in colon cancer stem cells. | Journal of cellular physiology 20101101 |
| T-type calcium channel antagonists suppress tremor in two mouse models of essential tremor. | Neuropharmacology 20101101 |
| The role of CYP2D6 and ABCB1 pharmacogenetics in drug-naïve patients with first-episode schizophrenia treated with risperidone. | European journal of clinical pharmacology 20101101 |
| Clinical experience with bosentan and sitaxentan in connective tissue disease-associated pulmonary arterial hypertension. | Rheumatology (Oxford, England) 20101101 |
| Abolished synthesis of cholic acid reduces atherosclerotic development in apolipoprotein E knockout mice. | Journal of lipid research 20101101 |
| Reduction of N-hydroxy-sulfonamides, including N-hydroxy-valdecoxib, by the molybdenum-containing enzyme mARC. | Drug metabolism and disposition: the biological fate of chemicals 20101101 |
| Tolerability of paliperidone: a meta-analysis of randomized, controlled trials. | International clinical psychopharmacology 20101101 |
| Endothelin-mediated gut microcirculatory dysfunction during porcine endotoxaemia. | British journal of anaesthesia 20101101 |
| Recent methodologies toward the synthesis of valdecoxib: a potential 3,4-diarylisoxazolyl COX-II inhibitor. | European journal of medicinal chemistry 20101101 |
| Synthesis and molluscicidal evaluation of some new pyrazole, isoxazole, pyridine, pyrimidine, 1,4-thiazine and 1,3,4-thiadiazine derivatives incorporating benzofuran moiety. | European journal of medicinal chemistry 20101101 |
| Enthalpy relaxation studies of two structurally related amorphous drugs and their binary dispersions. | Drug development and industrial pharmacy 20101101 |
| Armodafinil as adjunctive therapy in adults with cognitive deficits associated with schizophrenia: a 4-week, double-blind, placebo-controlled study. | The Journal of clinical psychiatry 20101101 |
| Zonisamide versus diazepam in the treatment of alcohol withdrawal syndrome. | Pharmacopsychiatry 20101101 |
| [Causes of selectivity, activation and inhibition. Molecular mechanisms of endothelin-receptor recognition]. | Pharmazie in unserer Zeit 20101101 |
| [Rituximab in the treatment of acquired haemophilia A in a patient with polymyalgia rheumatica]. | Hamostaseologie 20101101 |
| Development of an image-based system for measurement of membrane potential, intracellular Ca(2+) and contraction in arteriolar smooth muscle cells. | Microcirculation (New York, N.Y. : 1994) 20101101 |
| [Preemptive analgesic effect of parecoxib sodium in patients undergoing laparoscopic colorectal surgery]. | Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20101101 |
| Alterations in cyclic alternating pattern associated with phase advanced sleep are differentially modulated by gaboxadol and zolpidem. | Sleep 20101101 |
| Relative bioavailability of two oral formulations of risperidone 2 mg: A single-dose, randomized-sequence, open-label, two-period crossover comparison in healthy Brazilian volunteers. | Clinical therapeutics 20101101 |
| 1,5-Dimethyl-3-[(3-phenyl-4,5-dihydro-1,2-oxazol-5-yl)meth-yl]-1H-1,5-benzodiazepine-2,4(3H,5H)-dione. | Acta crystallographica. Section E, Structure reports online 20101101 |
| 4-tert-Butyl-4'-(4-meth-oxy-phen-yl)-3'-(4-methyl-phen-yl)-1,2,3,4-tetra-hydro-spiro-[naphthalene-2,5'(4'H)-1,2-oxazol]-1-one. | Acta crystallographica. Section E, Structure reports online 20101101 |
| [Discovery of an antiparkinsonian drug: zonisamide]. | Rinsho shinkeigaku = Clinical neurology 20101101 |
| Combination of sitaxentan and tadalafil for idiopathic pulmonary arterial hypertension following relapse on bosentan. | International journal of cardiology 20101029 |
| Novel agonists and antagonists for human protease activated receptor 2. | Journal of medicinal chemistry 20101028 |
| Assessment of efficacy and safety of FK778 in comparison with standard care in renal transplant recipients with untreated BK nephropathy. | Transplantation 20101027 |
| Synthesis, antimicrobial, and mosquito larvicidal activity of 1-aryl-4-methyl-3,6-bis-(5-methylisoxazol-3-yl)-2-thioxo-2,3,6,10b-tetrahydro-1H-pyrimido[5,4-c]quinolin-5-ones. | Bioorganic & medicinal chemistry letters 20101015 |
| A gram-scale batch and flow total synthesis of perhydrohistrionicotoxin. | Chemistry (Weinheim an der Bergstrasse, Germany) 20101004 |
| Zonisamide in managing impulse control disorders in Parkinson's disease. | Journal of neurology 20101001 |
| Preincisional versus postincisional administration of parecoxib in colorectal surgery: effect on postoperative pain control and cytokine response. A randomized clinical trial. | World journal of surgery 20101001 |
| Paliperidone-induced mania-like symptoms: a case report. | Progress in neuro-psychopharmacology & biological psychiatry 20101001 |
| Macrophage activation syndrome after leflunomide treatment in an adult rheumatoid arthritis patient. | Rheumatology (Oxford, England) 20101001 |
| Gender differences in the relationship between the risperidone metabolism and the plasma prolactin levels in psychiatric patients. | Progress in neuro-psychopharmacology & biological psychiatry 20101001 |
| Differential effects of antipsychotic and antidepressant drugs on neurogenic regions in rats. | Brain research 20101001 |
| Isoxazole analogs of curcuminoids with highly potent multidrug-resistant antimycobacterial activity. | European journal of medicinal chemistry 20101001 |
| Sildenafil added to sitaxsentan in overcirculation-induced pulmonary arterial hypertension. | American journal of physiology. Heart and circulatory physiology 20101001 |
| The herbicide ketoclomazone inhibits 1-deoxy-D-xylulose 5-phosphate synthase in the 2-C-methyl-D-erythritol 4-phosphate pathway and shows antibacterial activity against Haemophilus influenzae. | The Journal of antibiotics 20101001 |
| Paliperidone extended-release in schizoaffective disorder: a randomized, controlled study comparing a flexible dose with placebo in patients treated with and without antidepressants and/or mood stabilizers. | Journal of clinical psychopharmacology 20101001 |
| Base-catalyzed isomerization of 2-isoxazolines enables a two-step enantioselective synthesis of β-hydroxynitriles from enals. | The Journal of organic chemistry 20101001 |
| Renal failure five years after lung transplantation due to polyomavirus BK-associated nephropathy. | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20101001 |
| Paliperidone extended-release: a review of efficacy and tolerability in schizophrenia, schizoaffective disorder and bipolar mania. | Expert opinion on pharmacotherapy 20101001 |
| Short-term treatment with COX-2 inhibitors does not impair fracture healing. | Journal of investigative surgery : the official journal of the Academy of Surgical Research 20101001 |
| Parecoxib and fatal skin reactions: when will this drug be withdrawn from the European Union market? | Prescrire international 20101001 |
| 5-(4-Chloro-phen-yl)-6-isopropyl-5,6-dihydro-4H-pyrrolo-[3,4-c]isoxazole. | Acta crystallographica. Section E, Structure reports online 20101001 |
| 4-[(2-Hy-droxy-benzyl-idene)amino]-N-(5-methyl-isoxazol-3-yl)benzene-sulfonamide: a monoclinic polymorph. | Acta crystallographica. Section E, Structure reports online 20101001 |
| Design and synthesis of nonpeptidic, small molecule inhibitors for the Mycobacterium tuberculosis protein tyrosine phosphatase PtpB. | Organic & biomolecular chemistry 20100921 |
| Bitter pills for drug companies. | BMJ (Clinical research ed.) 20100917 |
| [Psychosis due to zonisamide: an infrequent case]. | Revista de neurologia 20100916 |
| Zonisamide reduces cell death in SH-SY5Y cells via an anti-apoptotic effect and by upregulating MnSOD. | Neuroscience letters 20100906 |
| Efficacy and safety of paliperidone palmitate in adult patients with acutely symptomatic schizophrenia: a randomized, double-blind, placebo-controlled, dose-response study. | International clinical psychopharmacology 20100901 |
| Maternal exposure to leflunomide and methotrexate in a patient with adult-onset Still's disease. | Rheumatology (Oxford, England) 20100901 |
| In vitro pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107. | The Journal of pharmacology and experimental therapeutics 20100901 |
| Eudragit S-100 entrapped chitosan microspheres of valdecoxib for colon cancer. | Journal of materials science. Materials in medicine 20100901 |
| A controlled, evidence-based trial of paliperidone palmitate, a long-acting injectable antipsychotic, in schizophrenia. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20100901 |
| Design, synthesis and biological evaluation of 3,5-diaryl-isoxazoline/isoxazole-pyrrolobenzodiazepine conjugates as potential anticancer agents. | European journal of medicinal chemistry 20100901 |
| Design and synthesis of novel isoxazole-based HDAC inhibitors. | European journal of medicinal chemistry 20100901 |
| Zonisamide ameliorates symptoms of secondary paroxysmal dystonia. | Pediatric neurology 20100901 |
| High-density lipoproteins suppress chemokines and chemokine receptors in vitro and in vivo. | Arteriosclerosis, thrombosis, and vascular biology 20100901 |
| Endothelin A receptor blockade improves regression of flow-induced pulmonary vasculopathy in piglets. | The Journal of thoracic and cardiovascular surgery 20100901 |
| Leflunomide: a drug with a potential beyond rheumatology. | Immunotherapy 20100901 |
| New antipsychotic drugs: how do their receptor-binding profiles compare? | The Journal of clinical psychiatry 20100901 |
| Therapeutic effect of a novel anti-parkinsonian agent zonisamide against MPTP (1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine) neurotoxicity in mice. | Metabolic brain disease 20100901 |
| [9-hydroxy-risperidone (9OHRIS) prevents stress-induced β-actin overexpression in rat hippocampus]. | Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology 20100901 |
| Relative bioavailability and pharmacokinetic comparison of two 2-mg risperidone tablet formulations: A single dose, randomized-sequence, double-blind, 2-way crossover study in healthy male volunteers in Thailand. | Clinical therapeutics 20100901 |
| Leflunomide: a small step forward in meeting the urgent need for treatment of drug-resistant cytomegalovirus infection. | Transplantation 20100827 |
| Utility of leflunomide in the treatment of complex cytomegalovirus syndromes. | Transplantation 20100827 |
| Successful treatment of extrapyramidal and psychotic symptoms with zonisamide in a patient with dementia with Lewy bodies. | Progress in neuro-psychopharmacology & biological psychiatry 20100816 |
| Using aripiprazole to attenuate paliperidone-induced hyperprolactinemia. | Progress in neuro-psychopharmacology & biological psychiatry 20100816 |
| Structural and binding studies of C-terminal half (C-lobe) of lactoferrin protein with COX-2-specific non-steroidal anti-inflammatory drugs (NSAIDs). | Archives of biochemistry and biophysics 20100815 |
| Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists. | Bioorganic & medicinal chemistry letters 20100815 |
| Chromatographic separation and sensitive determination of teriflunomide, an active metabolite of leflunomide in human plasma by liquid chromatography-tandem mass spectrometry. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100815 |
| Zonisamide discontinuation due to psychiatric and cognitive adverse events: a case-control study. | Neurology 20100810 |
| Orthogonally protected thiazole and isoxazole diamino acids: an efficient synthetic route. | Chemistry (Weinheim an der Bergstrasse, Germany) 20100809 |
| [Efficacy of paliperidone extended-release tablets in the improvement of social functions in schizophrenics: a randomized and controlled study]. | Zhonghua yi xue za zhi 20100803 |
| A putative role of micro RNA in regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes. | Journal of lipid research 20100801 |
| Serum concentrations of paliperidone versus risperidone and clinical effects. | European journal of clinical pharmacology 20100801 |
| Comment on: Factors associated with fatal outcome of leflunomide-induced lung injury in Japanese patients with rheumatoid arthritis. | Rheumatology (Oxford, England) 20100801 |
| Zonisamide: aspects in neuroprotection. | Experimental neurology 20100801 |
| Effectiveness of leflunomide in patients with juvenile idiopathic arthritis in clinical practice. | The Journal of rheumatology 20100801 |
| Leflunomide in the treatment of patients with early rheumatoid arthritis--results of a prospective non-interventional study. | Clinical rheumatology 20100801 |
| Do the blood pressure effects of nonsteroidal antiinflammatory drugs influence cardiovascular morbidity and mortality? | Current hypertension reports 20100801 |
| Iloperidone for schizophrenia. | Expert opinion on pharmacotherapy 20100801 |
| Identification of novel alpha7 nAChR positive allosteric modulators with the use of pharmacophore in silico screening methods. | Bioorganic & medicinal chemistry letters 20100801 |
| Comparison of the therapeutic effects of leflunomide and mycophenolate mofetil in the treatment of immunoglobulin A nephropathy manifesting with nephrotic syndrome. | International journal of clinical pharmacology and therapeutics 20100801 |
| Neuroleptic malignant syndrome secondary to aripiprazole initiation in a clozapine-intolerant patient. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20100801 |
| Studies on the acute toxicity, pharmacokinetics and pharmacodynamics of paliperidone derivatives--comparison to paliperidone and risperidone in mice and rats. | Basic & clinical pharmacology & toxicology 20100801 |
| One-year open-label safety and efficacy study of paliperidone extended-release tablets in patients with schizophrenia. | CNS spectrums 20100801 |
| The post-operative analgesic efficacy of celecoxib compared with placebo and parecoxib after total hip or knee arthroplasty. | Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20100801 |
| Iloperidone for the treatment of schizophrenia. | Drugs of today (Barcelona, Spain : 1998) 20100801 |
| tert-Butyl 3-(8-bromo-4H,10H-1,2-oxazolo[4,3-c][1]benzoxepin-10-yl)-2-methyl-1H-indole-1-carboxyl-ate. | Acta crystallographica. Section E, Structure reports online 20100801 |
| 2,10-Bis(3-bromo-phen-yl)-3,7,11,15-tetra-oxa-8,16-diaza-tricyclo-[12.2.1.1]octa-deca-1(16),6(18),8,14(17)-tetra-ene. | Acta crystallographica. Section E, Structure reports online 20100801 |
| N-(4-Chloro-benzyl-idene)-3,4-dimethyl-isoxazol-5-amine. | Acta crystallographica. Section E, Structure reports online 20100801 |
| Defective GABAergic neurotransmission and pharmacological rescue of neuronal hyperexcitability in the amygdala in a mouse model of fragile X syndrome. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20100721 |
| [Effects of parecoxib sodium preemptive analgesia on perioperative cytokine responses and stress responses in patients undergoing ophthalmology surgery]. | Zhonghua yi xue za zhi 20100720 |
| Paliperidone extended release: a review of its use in the management of schizophrenia. | Drugs 20100709 |
| The nuclear receptor FXR is expressed in pancreatic beta-cells and protects human islets from lipotoxicity. | FEBS letters 20100702 |
| Relationship between response to risperidone, plasma concentrations of risperidone and CYP3A4 polymorphisms in schizophrenia patients. | Journal of psychopharmacology (Oxford, England) 20100701 |
| Clinical response to risperidone in relation to plasma drug concentrations in acutely exacerbated schizophrenic patients. | Journal of psychopharmacology (Oxford, England) 20100701 |
| Preemptive analgesia reduces pain after radical axillary lymph node dissection. | The Journal of surgical research 20100701 |
| A comparison of serum prolactin concentrations after administration of paliperidone extended-release and risperidone tablets in patients with schizophrenia. | Journal of psychopharmacology (Oxford, England) 20100701 |
| Dual fluorochrome flow cytometric assessment of yeast viability. | Current microbiology 20100701 |
| The COX-2 inhibitor parecoxib is neuroprotective but not antiepileptogenic in the pilocarpine model of temporal lobe epilepsy. | Experimental neurology 20100701 |
| Long-acting injectable risperidone and metabolic ratio: a possible index of clinical outcome in treatment-resistant schizophrenic patients. | Psychopharmacology 20100701 |
| Single-dose pharmacokinetics of paliperidone extended-release tablets in healthy Chinese subjects. | Human psychopharmacology 20100701 |
| Pharmacotherapy: Is there a place for leflunomide in the treatment of RA? | Nature reviews. Rheumatology 20100701 |
| Paliperidone palmitate injection: Its efficacy, safety and tolerability in schizophrenia. | Drugs of today (Barcelona, Spain : 1998) 20100701 |
| [Different expression of GluR5 and GluR6 in rat astrocyte induced with coriaria lactone and ATPA]. | Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20100701 |
| Ligand-exchange processes on solvated zinc cations: water exchange on [Zn(H2O)4(L)]2+.2H2O (L=heterocyclic ligand). | Chemistry (Weinheim an der Bergstrasse, Germany) 20100625 |
| Pulvinar inactivation disrupts selection of movement plans. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20100623 |
| The synthesis of glycyrrhetinic acid derivatives containing a nitrogen heterocycle and their antiproliferative effects in human leukemia cells. | Molecules (Basel, Switzerland) 20100621 |
| Intramolecular Fe(II)-catalyzed N-O or N-N bond formation from aryl azides. | Organic letters 20100618 |
| Preparation and evaluation of biodegradable microspheres containing a new potent osteogenic compound and new synthetic polymers for sustained release. | International journal of pharmaceutics 20100615 |
| Synthesis and antitumor activity of 2,5-bis(3'-indolyl)-furans and 3,5-bis(3'-indolyl)-isoxazoles, nortopsentin analogues. | Bioorganic & medicinal chemistry 20100615 |
| Novel tricyclic Delta(2)-isoxazoline and 3-oxo-2-methyl-isoxazolidine derivatives: synthesis and binding affinity at neuronal nicotinic acetylcholine receptor subtypes. | Bioorganic & medicinal chemistry 20100615 |
| Synthesis of novel beta-lactam fused spiroisoxazolidine chromanones and tetralones as potent antimicrobial agent for human and plant pathogens. | Bioorganic & medicinal chemistry letters 20100615 |
| Synthesis and in vivo evaluation of [11C]MPTQ: a potential PET tracer for alpha2A-adrenergic receptors. | Bioorganic & medicinal chemistry letters 20100615 |
| Expanding the family of mesoionic complexes: donor properties and catalytic impact of palladated isoxazolylidenes. | Dalton transactions (Cambridge, England : 2003) 20100614 |
| Chemical synthesis of heterocyclic-sugar nucleoside analogues. | Chemical reviews 20100609 |
| An efficient entry to 1,2-benzisoxazoles via 1,3-dipolar cycloaddition of in situ generated nitrile oxides and benzyne. | Organic & biomolecular chemistry 20100607 |
| An expeditious synthesis of [1,2]isoxazolidin-5-ones and [1,2]oxazin-6-ones from functional allyl bromide derivatives. | Molecules (Basel, Switzerland) 20100607 |
| Paliperidone palmitate, a potential long-acting treatment for patients with schizophrenia. Results of a randomized, double-blind, placebo-controlled efficacy and safety study. | The international journal of neuropsychopharmacology 20100601 |
| Inconsistency in risperidone long-acting injection steady-state plasma levels when switching from deltoid to gluteal administration. | Journal of clinical pharmacology 20100601 |
| HRCT-proven leflunomide pneumonitis in a patient with psoriatic arthritis and normal lung function tests and chest radiography. | Rheumatology (Oxford, England) 20100601 |
| Synthesis of some 5-phenylisoxazole-3-carboxylic acid derivatives as potent xanthine oxidase inhibitors. | European journal of medicinal chemistry 20100601 |
| Synthesis and in vitro study of methylene-bis-tetrahydro[1,3]thiazolo[4,5-c]isoxazoles as potential nematicidal agents. | European journal of medicinal chemistry 20100601 |
| Extinction with varenicline and nornicotine, but not ABT-418, weakens conditioned responding evoked by the interoceptive stimulus effects of nicotine. | Neuropharmacology 20100601 |
| Increase of GABAA receptor-mediated tonic inhibition in dentate granule cells after traumatic brain injury. | Neurobiology of disease 20100601 |
| Effect of CYP2D6, CYP3A5, and MDR1 genetic polymorphisms on the pharmacokinetics of risperidone and its active moiety. | Journal of clinical pharmacology 20100601 |
| Greater functional ETB receptor antagonism with bosentan than sitaxsentan in healthy men. | Hypertension (Dallas, Tex. : 1979) 20100601 |
| Administration of zonisamide in three cases of dementia with Lewy bodies. | Psychiatry and clinical neurosciences 20100601 |
| Nuclear hormone receptors in diabetic nephropathy. | Nature reviews. Nephrology 20100601 |
| Therapeutic effect of a novel anti-parkinsonian agent zonisamide against MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) neurotoxicity in mice. | Metabolic brain disease 20100601 |
| Postoperative analgesia with parecoxib, acetaminophen, and the combination of both: a randomized, double-blind, placebo-controlled trial in patients undergoing thyroid surgery. | British journal of anaesthesia 20100601 |
| Hyperprolactinaemia during treatment with paliperidone. | Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists 20100601 |
| Urolithiasis on the ketogenic diet with concurrent topiramate or zonisamide therapy. | Epilepsy research 20100601 |
| Synthesis of a second generation chroman/catechol hybrids and evaluation of their activity in protecting neuronal cells from oxidative stress-induced cell death. | Bioorganic & medicinal chemistry 20100601 |
| A randomized, placebo-controlled study to assess the efficacy and safety of 3 doses of paliperidone palmitate in adults with acutely exacerbated schizophrenia. | Journal of clinical psychopharmacology 20100601 |
| Placebo-controlled trial of zonisamide for the treatment of alcohol dependence. | Journal of clinical psychopharmacology 20100601 |
| Leflunomide in combination therapy for rheumatoid arthritis. | Drug safety 20100601 |
| Efficacy and tolerability of paliperidone ER and other oral atypical antipsychotics in schizophrenia. | International journal of clinical pharmacology and therapeutics 20100601 |
| Healing of erosive disease in multicentric reticulohistiocytosis. | The Journal of rheumatology 20100601 |
| Teriflunomide (leflunomide) promotes cytostatic, antioxidant, and apoptotic effects in transformed prostate epithelial cells: evidence supporting a role for teriflunomide in prostate cancer chemoprevention. | Neoplasia (New York, N.Y.) 20100601 |
| [Postoperative analgesic effect of parecoxib sodium in patients with posterior spinal surgery]. | Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20100601 |
| Synthesis and preliminary antibacterial evaluation of 2-butyl succinate-based hydroxamate derivatives containing isoxazole rings. | Archives of pharmacal research 20100601 |
| Evaluation of the endothelin receptor antagonists ambrisentan, darusentan, bosentan, and sitaxsentan as substrates and inhibitors of hepatobiliary transporters in sandwich-cultured human hepatocytes. | Canadian journal of physiology and pharmacology 20100601 |
| Analgesic effect of parecoxib and flurbiprofen axetil for patients undergoing laparoscopic cholecystectomy and their influences on platelet aggregation. | Chinese medical journal 20100601 |
| X-ray structures of the LXRalpha LBD in its homodimeric form and implications for heterodimer signaling. | Journal of molecular biology 20100528 |
| Diversity of lysophosphatidic acid receptor-mediated intracellular calcium signaling in early cortical neurogenesis. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20100526 |
| Novel HSP90 inhibitors, NVP-AUY922 and NVP-BEP800, radiosensitise tumour cells through cell-cycle impairment, increased DNA damage and repair protraction. | British journal of cancer 20100525 |
| A selective cyclooxygenase-2 inhibitor suppresses the growth of endometriosis with an antiangiogenic effect in a rat model. | Fertility and sterility 20100515 |
| Synthesis and biological evaluation of phenolic 4,5-dihydroisoxazoles and 3-hydroxy ketones as estrogen receptor alpha and beta agonists. | Bioorganic & medicinal chemistry 20100515 |
| Unexpected heterocyclization of electrophilic alkenes by tetranitromethane in the presence of triethylamine. Synthesis of 3-nitroisoxazoles. | The Journal of organic chemistry 20100507 |
| An unnatural amino acid that mimics phosphotyrosine. | Chemical communications (Cambridge, England) 20100507 |
| Dithiolethione modified valproate and diclofenac increase E-cadherin expression and decrease proliferation of non-small cell lung cancer cells. | Lung cancer (Amsterdam, Netherlands) 20100501 |
| Severe aplastic anaemia following leflunomide therapy. | Rheumatology (Oxford, England) 20100501 |
| Comparison of combination therapies in the treatment of rheumatoid arthritis: leflunomide-anti-TNF-alpha versus methotrexate-anti-TNF-alpha. | Clinical rheumatology 20100501 |
| Birth outcomes in women who have taken leflunomide during pregnancy. | Arthritis and rheumatism 20100501 |
| Assessing the chemical diversity of an hsp90 database. | European journal of medicinal chemistry 20100501 |
| Adherence to disease-modifying antirheumatic drugs and the effects of exposure misclassification on the risk of hospital admission. | Arthritis care & research 20100501 |
| Iloperidone redux: a dissection of the Drug Approval Package for this newly commercialised second-generation antipsychotic. | International journal of clinical practice 20100501 |
| Differential oxidative metabolism and 5-ketoclomazone accumulation are involved in Echinochloa phyllopogon resistance to clomazone. | Plant physiology 20100501 |
| Medication satisfaction in schizophrenia: a blinded-initiation study of paliperidone extended release in patients suboptimally responsive to risperidone. | International clinical psychopharmacology 20100501 |
| Efficacy and safety of combining intra-articular methylprednisolone and anti-TNF agent to achieve prolonged remission in patients with recurrent inflammatory monoarthritis. | Joint, bone, spine : revue du rhumatisme 20100501 |
| Iloperidone for the treatment of schizophrenia. | The Annals of pharmacotherapy 20100501 |
| 89Zr-bevacizumab PET of early antiangiogenic tumor response to treatment with HSP90 inhibitor NVP-AUY922. | Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20100501 |
| The enhancement of contextual fear conditioning by ABT-418. | Behavioural pharmacology 20100501 |
| Mechanistic evaluation of the novel HSP90 inhibitor NVP-AUY922 in adult and pediatric glioblastoma. | Molecular cancer therapeutics 20100501 |
| Inhibition of HIV-1 replication by isoxazolidine and isoxazole sulfonamides. | Chemical biology & drug design 20100501 |
| A randomized, double-blind, placebo-controlled study of 2 dose ranges of paliperidone extended-release in the treatment of subjects with schizoaffective disorder. | The Journal of clinical psychiatry 20100501 |
| A randomized, placebo- and active-controlled study of paliperidone extended release for the treatment of acute manic and mixed episodes of bipolar I disorder. | Bipolar disorders 20100501 |
| Efficacy and safety of atypical antipsychotic drugs (quetiapine, risperidone, aripiprazole and paliperidone) compared with placebo or typical antipsychotic drugs for treating refractory schizophrenia: overview of systematic reviews. | Sao Paulo medical journal = Revista paulista de medicina 20100501 |
| 1-[(E)-(3,4-Dimethyl-isoxazol-5-yl)imino-meth-yl]-2-naphthol. | Acta crystallographica. Section E, Structure reports online 20100501 |
| Distinct activities of GABA agonists at synaptic- and extrasynaptic-type GABAA receptors. | The Journal of physiology 20100415 |
| A clomazone immunoassay to study the environmental fate of the herbicide in rice (Oryza sativa) agriculture. | Journal of agricultural and food chemistry 20100414 |
| Validation of method for determination of different classes of pesticides in aqueous samples by dispersive liquid-liquid microextraction with liquid chromatography-tandem mass spectrometric detection. | Analytica chimica acta 20100414 |
| Molecular characterization of agonists that bind to an insect GABA receptor. | Biochemistry 20100406 |
| Abatacept as an option therapy in difficult to treat psoriatic arthritis. | Rheumatology international 20100401 |
| Synergistic action of the novel HSP90 inhibitor NVP-AUY922 with histone deacetylase inhibitors, melphalan, or doxorubicin in multiple myeloma. | European journal of haematology 20100401 |
| Cyclooxygenase 2 inhibition exacerbates AQP2 and pAQP2 downregulation independently of V2 receptor abundance in the postobstructed kidney. | American journal of physiology. Renal physiology 20100401 |
| Peritonitis-induced peroxynitrite and lung damage depends on c-Jun NH2-terminal kinase signaling of hematopoietic cells. | Critical care medicine 20100401 |
| A prospective audit of adjunctive zonisamide in an everyday clinical setting. | Epilepsy & behavior : E&B 20100401 |
| Pharmacokinetic comparison and bioequivalence of two leflunomide formulations in humans: a single dose, randomized, open-label, two-way crossover study. | International journal of clinical pharmacology and therapeutics 20100401 |
| Preclinical antitumor activity of the orally available heat shock protein 90 inhibitor NVP-BEP800. | Molecular cancer therapeutics 20100401 |
| Inflammatory gene profile in early rheumatoid arthritis and modulation by leflunomide and prednisone treatment. | Annals of the New York Academy of Sciences 20100401 |
| Estrogens interfere with leflunomide modulation of cytokine production by human activated monocytes. | Annals of the New York Academy of Sciences 20100401 |
| Paliperidone use in the elderly. | Current drug safety 20100401 |
| Biotransformation of valdecoxib by microbial cultures. | Journal of microbiology and biotechnology 20100401 |
| Zonisamide: a new drug for Parkinson's disease. | Drugs of today (Barcelona, Spain : 1998) 20100401 |
| New-onset psoriasis associated with etanercept therapy. | The Journal of dermatology 20100401 |
| Manic symptoms induced by paliperidone. | Journal of clinical psychopharmacology 20100401 |
| Terizidone. | The Journal of the Association of Physicians of India 20100401 |
| Ethyl 3-{5-[(diethyl-amino)meth-yl]isoxazol-3-yl}-2-phenyl-pyrazolo[1,5-a]pyridine-5-carboxyl-ate. | Acta crystallographica. Section E, Structure reports online 20100401 |
| 2-[(E)-(3,4-Dimethyl-isoxazol-5-yl)imino-meth-yl]phenol. | Acta crystallographica. Section E, Structure reports online 20100401 |
| 5-(4-Fluoro-phen-yl)-4-(4-pyrid-yl)-1,3-oxazol-2-amine. | Acta crystallographica. Section E, Structure reports online 20100401 |
| Microbial degradation of clomazone under simulated California rice field conditions. | Journal of agricultural and food chemistry 20100324 |
| Efficient and regioselective synthesis of 5-hydroxy-2-isoxazolines: versatile synthons for isoxazoles, beta-lactams, and gamma-amino alcohols. | The Journal of organic chemistry 20100319 |
| Paliperidone overdose in a patient with schizophrenia. | Progress in neuro-psychopharmacology & biological psychiatry 20100317 |
| Design, synthesis, and herbicidal activities of novel 2-cyanoacrylates containing isoxazole moieties. | Journal of agricultural and food chemistry 20100310 |
| Effects of quetiapine, risperidone, 9-hydroxyrisperidone and ziprasidone on the survival of human neuronal and immune cells in vitro. | Journal of psychopharmacology (Oxford, England) 20100301 |
| Efficacy and tolerability of adjunctive therapy with zonisamide in childhood intractable epilepsy. | Brain & development 20100301 |
| Pharmacophore mapping and electronic feature analysis for a series of nitroaromatic compounds with antitubercular activity. | Journal of computational chemistry 20100301 |
| Prevalence of positive ppd in a cohort of rheumatoid arthritis patients. | Rheumatology international 20100301 |
| A comparison of continuous subcutaneous paliperidone infusion and repeated subcutaneous injection of risperidone free-base in rats. | European psychiatry : the journal of the Association of European Psychiatrists 20100301 |
| Leflunomide: is a new oral agent in treatment of acute pancreatitis? | Pancreas 20100301 |
| The usefulness of olfactory bulb kindling as a model for evaluation of antiepileptics. | Epilepsia 20100301 |
| High glucose increases expression of cyclooxygenase-2, increases oxidative stress and decreases the generation of nitric oxide in mouse microvessel endothelial cells. | Journal of cellular physiology 20100301 |
| Rituximab and concomitant leflunomide for the treatment of rheumatoid arthritis. | Rheumatology international 20100301 |
| Flexible dosing of adjunctive zonisamide in the treatment of adult partial-onset seizures: a non-comparative, open-label study (ZEUS). | Acta neurologica Scandinavica 20100301 |
| Modeling the effectiveness of paliperidone ER and olanzapine in schizophrenia: meta-analysis of 3 randomized, controlled clinical trials. | Journal of clinical pharmacology 20100301 |
| A rapid and simple high-performance liquid chromatography assay for the leflunomide metabolite, teriflunomide (A77 1726), in renal transplant recipients. | American journal of clinical pathology 20100301 |
| Intramuscular paliperidone palmitate. | CNS drugs 20100301 |
| Remission of drug-induced hepatitis after switching from risperidone to paliperidone. | The American journal of psychiatry 20100301 |
| Effect of parecoxib pretreatment and venous occlusion on propofol injection pain: a prospective, randomized, double-blinded, placebo-controlled study. | Journal of clinical anesthesia 20100301 |
| Serum concentrations, therapeutic response and side effects in children and adolescents with impulsive-aggressive symptoms during risperidone therapy. | Pharmacopsychiatry 20100301 |
| Open label trial of the tolerability and efficacy of zonisamide in the treatment of alcohol dependence. | The American journal of drug and alcohol abuse 20100301 |
| Biochemical and functional properties of distinct nicotinic acetylcholine receptors in the superior cervical ganglion of mice with targeted deletions of nAChR subunit genes. | The European journal of neuroscience 20100301 |
| (3-Phenyl-isoxazol-5-yl)methanol. | Acta crystallographica. Section E, Structure reports online 20100301 |
| Absence of weight gain association with the HTR2C -759C/T polymorphism in patients with schizophrenia treated with iloperidone. | Psychiatry research 20100227 |
| An improved synthesis of 1,2-benzisoxazoles: TBAF mediated 1,3-dipolar cycloaddition of nitrile oxides and benzyne. | Chemical communications (Cambridge, England) 20100227 |
| Iloperidone (Fanapt)--another second-generation antipsychotic. | The Medical letter on drugs and therapeutics 20100222 |
| Farnesoid X receptor, through the binding with steroidogenic factor 1-responsive element, inhibits aromatase expression in tumor Leydig cells. | The Journal of biological chemistry 20100219 |
| Exposure to the synthetic FXR agonist GW4064 causes alterations in gene expression and sublethal hepatotoxicity in eleutheroembryo medaka (Oryzias latipes). | Toxicology and applied pharmacology 20100215 |
| Phenyltriazolinones as potent factor Xa inhibitors. | Bioorganic & medicinal chemistry letters 20100215 |
| Effect of gaboxadol on patient-reported measures of sleep and waking function in patients with Primary Insomnia: results from two randomized, controlled, 3-month studies. | Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 20100215 |
| Combination regimen of leflunomide plus methylprednisolone in a female patient with reactive arthritis and concomitant IgA nephropathy. | Chinese medical journal 20100205 |
| Protective effects of leflunomide on intestinal ischemia-reperfusion injury: leflunomide against intestinal ischemia-reperfusion. | Digestive diseases and sciences 20100201 |
| Leflunomide therapy for BK virus allograft nephropathy in pediatric and young adult kidney transplant recipients. | Pediatric transplantation 20100201 |
| Electroencephalographic responses of tramadol, parecoxib and morphine to acute noxious electrical stimulation in anaesthetised dogs. | Research in veterinary science 20100201 |
| Selective antagonism of opioid-induced ventilatory depression by an ampakine molecule in humans without loss of opioid analgesia. | Clinical pharmacology and therapeutics 20100201 |
| The control of S-thiolation by cysteine via gamma-glutamyltranspeptidase and thiol exchanges in erythrocytes and plasma of diamide-treated rats. | Toxicology and applied pharmacology 20100201 |
| Physiological concentrations of choline activate native alpha7-containing nicotinic acetylcholine receptors in the presence of PNU-120596 [1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)-urea]. | The Journal of pharmacology and experimental therapeutics 20100201 |
| The antiepileptic drug zonisamide inhibits MAO-B and attenuates MPTP toxicity in mice: clinical relevance. | Experimental neurology 20100201 |
| Paliperidone palmitate maintenance treatment in delaying the time-to-relapse in patients with schizophrenia: a randomized, double-blind, placebo-controlled study. | Schizophrenia research 20100201 |
| Practical guidance for dosing and switching paliperidone palmitate treatment in patients with schizophrenia. | Current medical research and opinion 20100201 |
| Spinal macrophage migration inhibitory factor contributes to the pathogenesis of inflammatory hyperalgesia in rats. | Pain 20100201 |
| Simultaneous HPLC-UV analysis of rufinamide, zonisamide, lamotrigine, oxcarbazepine monohydroxy derivative and felbamate in deproteinized plasma of patients with epilepsy. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100201 |
| Synthesis and antituberculosis activity of novel mefloquine-isoxazole carboxylic esters as prodrugs. | Bioorganic & medicinal chemistry letters 20100201 |
| (89)Zr-trastuzumab PET visualises HER2 downregulation by the HSP90 inhibitor NVP-AUY922 in a human tumour xenograft. | European journal of cancer (Oxford, England : 1990) 20100201 |
| Possible neuroleptic malignant syndrome during paliperidone administration: a case report. | Journal of clinical psychopharmacology 20100201 |
| Protective effects of selective and non-selective cyclooxygenase inhibitors in an animal model of chronic stress. | Neuroscience bulletin 20100201 |
| Identification of a novel Raf-1 pathway activator that inhibits gastrointestinal carcinoid cell growth. | Molecular cancer therapeutics 20100201 |
| Efficacy of leflunomide for treatment of immune-mediated polyarthritis in dogs: 14 cases (2006-2008). | Journal of the American Veterinary Medical Association 20100201 |
| The Achilles heel of endothelin receptor therapy for pulmonary arterial hypertension. | The European respiratory journal 20100201 |
| Effect of leflunomide on liver regeneration after partial hepatectomy in rats. | Pediatric surgery international 20100201 |
| [Zonisamide in the preventive treatment of refractory migraine]. | Revista de neurologia 20100201 |
| Paliperidone for irritability in autistic disorder. | Journal of child and adolescent psychopharmacology 20100201 |
| Endometriosis: in search of optimal treatment. | Minerva ginecologica 20100201 |
| [The discovery of an antiparkinsonian drug, zonisamide]. | Rinsho shinkeigaku = Clinical neurology 20100201 |
| Paliperidone extended-release tablets in patients with recently diagnosed schizophrenia. | Early intervention in psychiatry 20100201 |
| [Endothelin receptor antagonists in the new European guidelines on pulmonary hypertension]. | Revue des maladies respiratoires 20100201 |
| Measuring social functioning with the personal and social performance scale in patients with acute symptoms of schizophrenia: interpretation of results of a pooled analysis of three Phase III trials of paliperidone extended-release tablets. | Clinical therapeutics 20100201 |
| [Selective inhibitors of cyclooxygenase-2 (COX-2), celecoxib and parecoxib: a systematic review]. | Drugs of today (Barcelona, Spain : 1998) 20100201 |
| Neuroprotective effects of zonisamide target astrocyte. | Annals of neurology 20100201 |
| Infantile spasms: who are the ideal surgical candidates? | Epilepsia 20100201 |
| Steady-state pharmacokinetics of zonisamide in plasma, whole blood, and erythrocytes in dogs. | Journal of veterinary pharmacology and therapeutics 20100201 |
| Microwave-promoted synthesis of 3-amino-substituted 1,2-benzisoxazoles. | Future medicinal chemistry 20100201 |
| 5-Hydroxy-L-tryptophan alters gaboxadol pharmacokinetics in rats: involvement of PAT1 and rOat1 in gaboxadol absorption and elimination. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20100131 |
| Rational design of 5-phenyl-3-isoxazolecarboxylic acid ethyl esters as growth inhibitors of Mycobacterium tuberculosis. a potent and selective series for further drug development. | Journal of medicinal chemistry 20100128 |
| Nucleoside and nucleotide analogues by catalyst free Huisgen nitrile oxide-alkyne 1,3-dipolar cycloaddition. | Organic & biomolecular chemistry 20100121 |
| Rupintrivir is a promising candidate for treating severe cases of Enterovirus-71 infection. | World journal of gastroenterology 20100114 |
| Elevated liver enzyme tests among patients with rheumatoid arthritis or psoriatic arthritis treated with methotrexate and/or leflunomide. | Annals of the rheumatic diseases 20100101 |
| Measure of function in rheumatoid arthritis: individualised or classical scales? | Annals of the rheumatic diseases 20100101 |
| Efficacy and safety of paliperidone extended-release in schizophrenia patients with prominent affective symptoms. | Journal of affective disorders 20100101 |
| Glutamate-dopamine crosstalk in the rat prefrontal cortex is modulated by Alpha7 nicotinic receptors and potentiated by PNU-120596. | Journal of molecular neuroscience : MN 20100101 |
| Migratory response of mesenchymal stem cells to macrophage migration inhibitory factor and its antagonist as a function of colony-forming efficiency. | Biotechnology letters 20100101 |
| Microarray analysis of Leflunomide-induced limb malformations in CD-1 mice. | Reproductive toxicology (Elmsford, N.Y.) 20100101 |
| Paliperidone palmitate - review of the efficacy, safety and cost of a new second-generation depot antipsychotic medication. | International journal of clinical practice 20100101 |
| [Hepatotoxicity induced by new immunosuppressants]. | Gastroenterologia y hepatologia 20100101 |
| Electrophysiological actions of zonisamide on striatal neurons: Selective neuroprotection against complex I mitochondrial dysfunction. | Experimental neurology 20100101 |
| Reaction of naphthoquinones with substituted nitromethanes. Facile synthesis and antifungal activity of naphtho[2,3-d]isoxazole-4,9-diones. | Bioorganic & medicinal chemistry letters 20100101 |
| Isoxazole analogues bind the system xc- transporter: structure-activity relationship and pharmacophore model. | Bioorganic & medicinal chemistry 20100101 |
| Zonisamide-induced weight loss in schizophrenia: case series. | Clinical neuropharmacology 20100101 |
| Effectiveness and tolerability of zonisamide in children with epilepsy: a retrospective review. | Seizure 20100101 |
| Water mediated construction of trisubstituted pyrazoles/isoxazoles library using ketene dithioacetals. | Journal of combinatorial chemistry 20100101 |
| Zonisamide in the treatment of epilepsy. | Expert opinion on pharmacotherapy 20100101 |
| Mice lacking Gad2 show altered behavioral effects of ethanol, flurazepam and gabaxadol. | Addiction biology 20100101 |
| Zonisamide in Parkinson's disease: profile report. | Drugs & aging 20100101 |
| Determination of acid dissociation constants of compounds active at neuronal nicotinic acetylcholine receptors by means of electrophoretic and potentiometric techniques. | Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20100101 |
| The effects of sitaxentan on sildenafil pharmacokinetics and pharmacodynamics in healthy subjects. | British journal of clinical pharmacology 20100101 |
| Effects of Parecoxib and Fentanyl on nociception-induced cortical activity. | Molecular pain 20100101 |
| New drugs: asenapine, iloperidone, and bepotastine besilate. | Journal of the American Pharmacists Association : JAPhA 20100101 |
| The pharmacokinetics of paliperidone versus risperidone. | Psychosomatics 20100101 |
| Leflunomide induces immunosuppression in collagen-induced arthritis rats by upregulating CD4+CD25+ regulatory T cells. | Canadian journal of physiology and pharmacology 20100101 |
| Regulation of cerebromicrovascular permeability by lysophosphatidic acid. | Microcirculation (New York, N.Y. : 1994) 20100101 |
| Hemodynamics in pulmonary arterial hypertension (PAH): do they explain long-term clinical outcomes with PAH-specific therapy? | BMC cardiovascular disorders 20100101 |
| Acute kidney injury caused by zonisamide-induced hypersensitivity syndrome. | Internal medicine (Tokyo, Japan) 20100101 |
| A randomised comparison of parecoxib versus placebo for pain management following minor day stay gynaecological surgery. | Anaesthesia and intensive care 20100101 |
| The role of macrophage migration inhibitory factor in Alzheimer's disease. | Molecular medicine (Cambridge, Mass.) 20100101 |
| [Therapeutic drug monitoring of zonisamide]. | Therapie 20100101 |
| Oral Therapies for the treatment of pulmonary arterial hypertension: a population-based cost-minimization analysis. | Applied health economics and health policy 20100101 |
| Leg ulceration in rheumatoid arthritis--an underreported multicausal complication with considerable morbidity: analysis of thirty-six patients and review of the literature. | Dermatology (Basel, Switzerland) 20100101 |
| New atypical antipsychotics for schizophrenia: iloperidone. | Drug design, development and therapy 20100101 |
| Methotrexate plus leflunomide for the treatment of relapsingWegener's granulomatosis. A retrospective uncontrolled study. | Clinical and experimental rheumatology 20100101 |
| ISO-1, a macrophage migration inhibitory factor antagonist, inhibits airway remodeling in a murine model of chronic asthma. | Molecular medicine (Cambridge, Mass.) 20100101 |
| Leflunomide derivate FK 778 in accelerated renal injury in transgenic rat. | Folia biologica 20100101 |
| In vitro and in vivo comparison of the anti-staphylococcal efficacy of generic products and the innovator of oxacillin. | BMC infectious diseases 20100101 |
| [Diagnosis and management of small vessel vasculitides]. | Duodecim; laaketieteellinen aikakauskirja 20100101 |
| Eco-contribution for the production of N-arylnitrones: solvent-free and assisted by microwaves. | International journal of molecular sciences 20100101 |
| The effect of leflunomide on cycling and activation of T-cells in HIV-1-infected participants. | PloS one 20100101 |
| Effects of zonisamide in the treatment of alcohol dependence. | Clinical neuropharmacology 20100101 |
| Selective COX-1 inhibition: A therapeutic target to be reconsidered. | Current medicinal chemistry 20100101 |
| Inhibitory effect of selective cyclooxygenase-2 inhibitor lumiracoxib on human organic anion transporters hOAT1 and hOAT3. | Drug metabolism and pharmacokinetics 20100101 |
| Exploratory analysis of psychiatric-related utilization and costs associated with paliperidone ER compared with other oral atypical antipsychotics using pharmacy claims from an administrative database. | Journal of medical economics 20100101 |
| Influence of long-term leflunomide treatment on serum amyloid concentration in rheumatoid arthritis patients. | Pharmacological reports : PR 20100101 |
| Macrophage migration inhibitory factor regulates interleukin-6 production by facilitating nuclear factor-kappa B activation during Vibrio vulnificus infection. | BMC immunology 20100101 |
| Zonisamide attenuates MPTP neurotoxicity in marmosets. | Journal of pharmacological sciences 20100101 |
| The anti-inflammatory drug leflunomide is an agonist of the aryl hydrocarbon receptor. | PloS one 20100101 |
| Paliperidone-induced dystonic Dysphagia. | The Journal of neuropsychiatry and clinical neurosciences 20100101 |
| Inhibition of endothelin-1-mediated contraction of hepatic stellate cells by FXR ligand. | PloS one 20100101 |
| Activation of functional α7-containing nAChRs in hippocampal CA1 pyramidal neurons by physiological levels of choline in the presence of PNU-120596. | PloS one 20100101 |
| Does the anti-herpesviral effect of leflunomide play a role in the treatment of rheumatoid arthritis? | Clinical and experimental rheumatology 20100101 |
| [Non-fatal paliperidone overdose: a case report]. | Turk psikiyatri dergisi = Turkish journal of psychiatry 20100101 |
| Metabotropic glutamate receptors: potential drug targets for psychiatric disorders. | The open medicinal chemistry journal 20100101 |
| [Peripheral neuropathy caused by leflunomide. A case reported with a brief review]. | Revista medica del Instituto Mexicano del Seguro Social 20100101 |
| The pharmacotherapy of alcohol dependence: a state of the art review. | Mens sana monographs 20100101 |
| [Active psoriatic arthritis during pregnancy: challenges and limitations of pharmacotherapy]. | Annales Academiae Medicae Stetinensis 20100101 |
| (E)-N'-Benzyl-idene-5-methyl-isoxazole-4-carbohydrazide. | Acta crystallographica. Section E, Structure reports online 20100101 |
| 5-Methyl-N'-(3-nitrobenzylidene)isoxazole-4-carbohydrazide. | Acta crystallographica. Section E, Structure reports online 20100101 |
| QSAR studies of benzofuran/benzothiophene biphenyl derivatives as inhibitors of PTPase-1B. | Journal of pharmacy & bioallied sciences 20100101 |
| [Treatment of rheumatoid and psoriatic arthritis--review of leflunomide]. | Reumatizam 20100101 |
| Discovery of 3-aryl-4-isoxazolecarboxamides as TGR5 receptor agonists. | Journal of medicinal chemistry 20091224 |
| Efficient chemoenzymatic dynamic kinetic resolution of 1-heteroaryl ethanols. | The Journal of organic chemistry 20091218 |
| Enantioselective intramolecular oxidative aminocarbonylation of alkenylureas catalyzed by palladium-spiro bis(isoxazoline) complexes. | The Journal of organic chemistry 20091218 |
| 3,4-Diaryl-isoxazoles and -imidazoles as potent dual inhibitors of p38alpha mitogen activated protein kinase and casein kinase 1delta. | Journal of medicinal chemistry 20091210 |
| Simultaneous determination of risperidone and 9-hydroxyrisperidone enantiomers in human blood plasma by liquid chromatography with electrochemical detection. | Journal of pharmaceutical and biomedical analysis 20091205 |
| Synthesis of novel 6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole derivatives as antiproliferative agents: a structure-activity relationship study. | Investigational new drugs 20091201 |
| Comparative effectiveness of tumour necrosis factor alpha inhibitors in combination with either methotrexate or leflunomide. | Annals of the rheumatic diseases 20091201 |
| Highway driving performance and cognitive functioning the morning after bedtime and middle-of-the-night use of gaboxadol, zopiclone and zolpidem. | Journal of sleep research 20091201 |
| Commentary: genome-based CNS drug discovery: D-amino acid oxidase (DAAO) as a novel target for antipsychotic medications: progress and challenges. | Biochemical pharmacology 20091201 |
| Analgesic, anticonvulsant and anti-inflammatory activities of some synthesized benzodiazipine, triazolopyrimidine and bis-imide derivatives. | European journal of medicinal chemistry 20091201 |
| Enaminonitrile in heterocyclic synthesis: synthesis and antimicrobial evaluation of some new pyrazole, isoxazole and pyrimidine derivatives incorporating a benzothiazole moiety. | European journal of medicinal chemistry 20091201 |
| Leflunomide for the successful management of juvenile Cogan's syndrome. | Clinical rheumatology 20091201 |
| Structure of alpha6 beta3 delta GABA(A) receptors and their lack of ethanol sensitivity. | Journal of neurochemistry 20091201 |
| Impact of CYP2D6 genotype on steady-state serum concentrations of risperidone and 9-hydroxyrisperidone in patients using long-acting injectable risperidone. | Journal of clinical psychopharmacology 20091201 |
| Progesterone and allopregnanolone enhance the miniature synaptic release of glycine in the rat hypoglossal nucleus. | The European journal of neuroscience 20091201 |
| Iloperidone: a new option for the treatment of schizophrenia. | Expert review of neurotherapeutics 20091201 |
| Successful treatment of leflunomide-induced acute pneumonitis with cholestyramine wash-out therapy. | Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 20091201 |
| Zonisamide in West syndrome: an open label study. | Epileptic disorders : international epilepsy journal with videotape 20091201 |
| Positive allosteric modulation of alpha7 neuronal nicotinic acetylcholine receptors: lack of cytotoxicity in PC12 cells and rat primary cortical neurons. | British journal of pharmacology 20091201 |
| Multimodal pain management following minimally invasive total knee arthroplasty: an experience in 3-dose parecoxib. | Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20091201 |
| [Successful quetiapine therapy in psychotic patients with mood elevation]. | Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology 20091201 |
| Leflunomide derivative FK778 inhibits production of antibodies in an experimental model of alloreactive T-B cell interaction. | Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation 20091201 |
| 1-(3-p-Tolyl-isoxazol-5-yl)cyclo-hexa-nol. | Acta crystallographica. Section E, Structure reports online 20091201 |
| 4-(2-Hydroxy-benzyl-idene)-3-methyl-isoxazol-5(4H)-one. | Acta crystallographica. Section E, Structure reports online 20091201 |
| (Z)-4-[4-(Dimethyl-amino)benzyl-idene]-3-methyl-isoxazol-5(4H)-one. | Acta crystallographica. Section E, Structure reports online 20091201 |
| N'-[(E)-2-Hydroxy-benzyl-idene]-5-methyl-isoxazole-4-carbohydrazide monohydrate. | Acta crystallographica. Section E, Structure reports online 20091201 |
| 5-Methyl-isoxazole-4-carboxylic acid. | Acta crystallographica. Section E, Structure reports online 20091201 |
| (20S,2''S)-20-[4'-(3''-Hydroxy-2''-methyl-prop-yl)-3'-methylisoxazol-5-yl]-5β-preg-nan-3β,16β-diol. | Acta crystallographica. Section E, Structure reports online 20091201 |
| [Role of zonisamid in treating epilepsy, Parkinson disorders and other neurological diseases]. | Ideggyogyaszati szemle 20091130 |
| Inhibition of polyomavirus BK-specific T-Cell responses by immunosuppressive drugs. | Transplantation 20091127 |
| From serendipity to rational antituberculosis drug discovery of mefloquine-isoxazole carboxylic acid esters. | Journal of medicinal chemistry 20091126 |
| Role of water in the multifaceted catalytic antibody 4B2 for allylic isomerization and Kemp elimination reactions. | The journal of physical chemistry. B 20091119 |
| Simple, rapid, and highly sensitive detection of diphosgene and triphosgene by spectrophotometric methods. | Talanta 20091115 |
| Anthranilic sulfonamide CCK1/CCK2 dual receptor antagonists I: discovery of CCKR1 selectivity in a previously CCKR2-selective lead series. | Bioorganic & medicinal chemistry letters 20091115 |
| Anthranilic sulfonamide CCK1/CCK2 dual receptor antagonists II: tuning of receptor selectivity and in vivo efficacy. | Bioorganic & medicinal chemistry letters 20091115 |
| Searching for new cures for tuberculosis: design, synthesis, and biological evaluation of 2-methylbenzothiazoles. | Journal of medicinal chemistry 20091112 |
| [Referring to an unusual case: pulmonary affection and rheumatoid arthritis]. | Revue medicale suisse 20091111 |
| 3,5-Isoxazoles from alpha-bromo-pentafluorophenyl vinylsulfonates: synthesis of sulfonates and sulfonamides. | Organic & biomolecular chemistry 20091107 |
| In brief: Injectable paliperidone palmitate for schizophrenia. | The Medical letter on drugs and therapeutics 20091102 |
| Whole genome association study identifies polymorphisms associated with QT prolongation during iloperidone treatment of schizophrenia. | Molecular psychiatry 20091101 |
| Ostreolysin induces sustained contraction of porcine coronary arteries and endothelial dysfunction in middle- and large-sized vessels. | Toxicon : official journal of the International Society on Toxinology 20091101 |
| Parecoxib does not suppress thromboxane synthesis in newborn piglets with group B streptococcal sepsis. | Prostaglandins & other lipid mediators 20091101 |
| Heterocyclic replacement of the central phenyl core of diamine-based histamine H3 receptor antagonists. | European journal of medicinal chemistry 20091101 |
| Synthesis, antimicrobial and antioxidant activities of substituted pyrazoles, isoxazoles, pyrimidine and thioxopyrimidine derivatives. | European journal of medicinal chemistry 20091101 |
| In vitro and in vivo properties of 3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABAA receptor alpha5 subtype-selective inverse agonist. | The Journal of pharmacology and experimental therapeutics 20091101 |
| Single- and multiple-dose pharmacokinetics and dose proportionality of the psychotropic agent paliperidone extended release. | Journal of clinical pharmacology 20091101 |
| Drug loaded poly[Lac(Glc-Leu)] microparticles: formulation and release characteristics. | Colloids and surfaces. B, Biointerfaces 20091101 |
| Antibacterial activity, quantitative structure-activity relationship and diastereoselective synthesis of isoxazolidine derivatives via 1,3-dipolar cycloaddition of d-glucose derived nitrone with olefin. | Chemical biology & drug design 20091101 |
| Photodegradation of sulfamethoxazole in various aqueous media: persistence, toxicity and photoproducts assessment. | Chemosphere 20091101 |
| Synthesis and biological activity of a new class of sulfone-linked pyrrolylpyrazoles and pyrrolylisoxazoles from methyl-3-aryl-2-(E-arylethenesulfonyl)acrylate. | Chemical & pharmaceutical bulletin 20091101 |
| Leflunomide in the treatment of palmoplantar pustulosis. | Archives of dermatology 20091101 |
| Bioavailability of diuron, imazapic and isoxaflutole in soils of contrasting textures. | Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 20091101 |
| 5-Methyl-3-[1-(2-pyridylmeth-yl)-1H-benzimidazol-2-ylmeth-yl]isoxazole. | Acta crystallographica. Section E, Structure reports online 20091101 |
| Effects of the antipsychotic risperidone on dopamine synthesis in human brain measured by positron emission tomography with L-[beta-11C]DOPA: a stabilizing effect for dopaminergic neurotransmission? | The Journal of neuroscience : the official journal of the Society for Neuroscience 20091028 |
| Parecoxib has non-significant long-term effects on bone healing in rats when administered for a short period after fracture. | Archives of orthopaedic and trauma surgery 20091001 |
| Inhibition of tumour necrosis factor and IL-17 production by leflunomide involves the JAK/STAT pathway. | Annals of the rheumatic diseases 20091001 |
| Endothelin receptor antagonism and renin inhibition as treatment options for scleroderma kidney. | American journal of kidney diseases : the official journal of the National Kidney Foundation 20091001 |
| Pharmacological treatment (biotherapy excluded) of peripheral psoriatic arthritis: development of recommendations for clinical practice based on data from the literature and experts opinion. | Joint, bone, spine : revue du rhumatisme 20091001 |
| Neonatal allopregnanolone increases novelty-directed locomotion and disrupts behavioural responses to GABA(A) receptor modulators in adulthood. | International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20091001 |
| Comparative pharmacology and computational modelling yield insights into allosteric modulation of human alpha7 nicotinic acetylcholine receptors. | Biochemical pharmacology 20091001 |
| Cyclooxygenase-2 inhibitors down-regulate osteopontin and Nr4A2-new therapeutic targets for colorectal cancers. | Gastroenterology 20091001 |
| Paliperidone for treatment of obsessive compulsive resistant symptoms in schizophrenia: a case report. | Progress in neuro-psychopharmacology & biological psychiatry 20091001 |
| Investigation of the influence of CYP1A2 and CYP2C19 genetic polymorphism on 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide (A77 1726) pharmacokinetics in leflunomide-treated patients with rheumatoid arthritis. | Drug metabolism and disposition: the biological fate of chemicals 20091001 |
| Coordinated regulation of dimethylarginine dimethylaminohydrolase-1 and cationic amino acid transporter-1 by farnesoid X receptor in mouse liver and kidney and its implication in the control of blood levels of asymmetric dimethylarginine. | The Journal of pharmacology and experimental therapeutics 20091001 |
| Factors associated with fatal outcome of leflunomide-induced lung injury in Japanese patients with rheumatoid arthritis. | Rheumatology (Oxford, England) 20091001 |
| No pharmacokinetic interaction between paliperidone extended-release tablets and trimethoprim in healthy subjects. | Human psychopharmacology 20091001 |
| A strategy of employing aminoheterocycles as amide mimics to identify novel, potent and bioavailable soluble epoxide hydrolase inhibitors. | Bioorganic & medicinal chemistry letters 20091001 |
| Successful treatment of idiopathic orbital inflammatory disease with leflunomide: a case report. | Southern medical journal 20091001 |
| Iloperidone: in schizophrenia. | CNS drugs 20091001 |
| Independent effect of paliperidone extended release on social functioning beyond its effect on positive and negative symptoms of schizophrenia: a mediation analysis. | Journal of clinical psychopharmacology 20091001 |
| The influence of hepatic impairment on the pharmacokinetics of paliperidone. | International journal of clinical pharmacology and therapeutics 20091001 |
| Clinical and cost-effectiveness of epoprostenol, iloprost, bosentan, sitaxentan and sildenafil for pulmonary arterial hypertension within their licensed indications: a systematic review and economic evaluation. | Health technology assessment (Winchester, England) 20091001 |
| 3-(6-Benz-yloxy-2,2-dimethyl-perhydro-furo[2,3-d][1,3]dioxolan-5-yl)-5-(4-chloro-phen-yl)-4-nitro-2-phenyl-2,3,4,5-tetra-hydro-isoxazole. | Acta crystallographica. Section E, Structure reports online 20091001 |
| 4-(4-Chloro-phen-yl)-5-phenyl-isoxazole. | Acta crystallographica. Section E, Structure reports online 20091001 |
| Discovery of a novel class of isoxazoline voltage gated sodium channel blockers. | Bioorganic & medicinal chemistry letters 20090915 |
| Discovery of isoxazole voltage gated sodium channel blockers for treatment of chronic pain. | Bioorganic & medicinal chemistry letters 20090915 |
| Lack of nucleophilic addition in the isoxazole and pyrazole diketone modified analogs of curcumin; implications for their antitumor and chemosensitizing activities. | Chemico-biological interactions 20090914 |
| Integrin priming dynamics: mechanisms of integrin antagonist-promoted alphaIIbbeta3:PAC-1 molecular recognition. | Biochemistry 20090908 |
| Efficient and regioselective one-pot synthesis of 3-substituted and 3,5-disubstituted isoxazoles. | Organic letters 20090903 |
| Syringotropic hypersensitivity reaction associated with infliximab and leflunomide combination therapy in a child with psoriatic arthritis. | Journal of cutaneous pathology 20090901 |
| The efficacy and safety of leflunomide therapy in lupus nephritis by repeat kidney biopsy. | Rheumatology international 20090901 |
| A novel anti-Parkinsonian agent, zonisamide, attenuates MPTP-induced neurotoxicity in mice. | Journal of molecular neuroscience : MN 20090901 |
| Small-molecule antagonist of macrophage migration inhibitory factor enhances migratory response of mesenchymal stem cells to bronchial epithelial cells. | Tissue engineering. Part A 20090901 |
| Clinical expression of leflunomide-induced pneumonitis. | Rheumatology (Oxford, England) 20090901 |
| Leflunomide-induced interstitial lung disease: prevalence and risk factors in Japanese patients with rheumatoid arthritis. | Rheumatology (Oxford, England) 20090901 |
| Determination of risperidone and 9-Hydroxyrisperidone using HPLC, in plasma of children and adolescents with emotional and behavioural disorders. | Biomedical chromatography : BMC 20090901 |
| Pharmacokinetics of intramuscular microparticle depot of valdecoxib in an experimental model. | Drug development and industrial pharmacy 20090901 |
| Zonisamide enhances delta receptor-associated neurotransmitter release in striato-pallidal pathway. | Neuropharmacology 20090901 |
| Human 5-HT7 receptor-induced inactivation of forskolin-stimulated adenylate cyclase by risperidone, 9-OH-risperidone and other 'inactivating antagonists'. | Molecular pharmacology 20090901 |
| Leflunomide and the lung. | Rheumatology (Oxford, England) 20090901 |
| Effects of essential fatty acid deficiency on enterohepatic circulation of bile salts in mice. | American journal of physiology. Gastrointestinal and liver physiology 20090901 |
| New series of monoquaternary pyridinium oximes: Synthesis and reactivation potency for paraoxon-inhibited electric eel and recombinant human acetylcholinesterase. | Bioorganic & medicinal chemistry letters 20090901 |
| The first line of therapy in a girl with juvenile myoclonic epilepsy: should it be valproate or a new agent? | Epilepsia 20090901 |
| Efficacy and tolerability of zonisamide as add-on in brain tumor-related epilepsy: preliminary report. | Acta neurologica Scandinavica 20090901 |
| Safety and tolerability of deltoid and gluteal injections of paliperidone palmitate in schizophrenia. | Progress in neuro-psychopharmacology & biological psychiatry 20090831 |
| Ampakine therapy to counter fentanyl-induced respiratory depression. | Respiratory physiology & neurobiology 20090831 |
| Lack of correlation between the central anti-nociceptive and peripheral anti-inflammatory effects of selective COX-2 inhibitor parecoxib. | Brain research bulletin 20090828 |
| 3-(Arylthiomethyl)isoxazole-4,5-dicarboxamides: chemoselective nucleophilic chemistry and insecticidal activity. | Journal of agricultural and food chemistry 20090826 |
| Theoretical investigations of the photochemical isomerizations of indoxazene and isoxazole. | The Journal of organic chemistry 20090821 |
| FXR agonist activity of conformationally constrained analogs of GW 4064. | Bioorganic & medicinal chemistry letters 20090815 |
| Novel derivatives of ISO-1 as potent inhibitors of MIF biological function. | Bioorganic & medicinal chemistry letters 20090815 |
| Time resolved analysis of risperidone and 9-hydroxy-risperidone in hair using LC/MS-MS. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090815 |
| C5-Modified nucleosides exhibiting anticancer activity. | Bioorganic & medicinal chemistry letters 20090815 |
| Association of the NPAS3 gene and five other loci with response to the antipsychotic iloperidone identified in a whole genome association study. | Molecular psychiatry 20090801 |
| Functional alpha 7-containing nicotinic receptors of NG2-expressing cells in the hippocampus. | Glia 20090801 |
| Parecoxib and indomethacin delay early fracture healing: a study in rats. | Clinical orthopaedics and related research 20090801 |
| A 2-week efficacy and safety study of gaboxadol and zolpidem using electronic diaries in primary insomnia outpatients. | Sleep medicine 20090801 |
| An allosteric modulator of alpha7 nicotinic receptors, N-(5-Chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)-urea (PNU-120596), causes conformational changes in the extracellular ligand binding domain similar to those caused by acetylcholine. | Molecular pharmacology 20090801 |
| Successful treatment of multicentric reticulohistiocytosis with leflunomide. | The British journal of dermatology 20090801 |
| Polyoma BK virus-associated nephropathy in kidney-transplant patients: Effects of leflunomide on T-cell functions and disease outcome. | International immunopharmacology 20090801 |
| Pharmacokinetics and efficacy of a direct switch from conventional depot to risperidone long-acting injection in Chinese patients with schizophrenic and schizoaffective disorders. | Psychiatry and clinical neurosciences 20090801 |
| Lysophosphatidic acid stimulates prostaglandin E2 production in cultured stromal endometrial cells through LPA1 receptor. | Experimental biology and medicine (Maywood, N.J.) 20090801 |
| Leflunomide use in renal transplantation. | Current opinion in organ transplantation 20090801 |
| Serum levels of risperidone and its metabolite, 9-hydroxyrisperidone: correlation between drug concentration and clinical response. | Therapeutic drug monitoring 20090801 |
| Paliperidone extended-release for schizophrenia: effects on symptoms and functioning in acutely ill patients with negative symptoms. | Schizophrenia research 20090801 |
| A systematic MEDLINE analysis of therapeutic approaches in ankylosing spondylitis. | Rheumatology international 20090801 |
| The regulatory effect of the p38 signaling pathway on valdecoxib-induced apoptosis of the Eca109 cell line. | Oncology reports 20090801 |
| Zonisamide: in Parkinson's disease. | CNS drugs 20090801 |
| Intestinal gaboxadol absorption via PAT1 (SLC36A1): modified absorption in vivo following co-administration of L-tryptophan. | British journal of pharmacology 20090801 |
| Dihydroorotate dehydrogenase polymorphism influences the toxicity of leflunomide treatment in patients with rheumatoid arthritis. | Annals of the rheumatic diseases 20090801 |
| Iloperidone for schizophrenia: a review of the efficacy and safety profile for this newly commercialised second-generation antipsychotic. | International journal of clinical practice 20090801 |
| Lysophosphatidic Acid signals through specific lysophosphatidic Acid receptor subtypes to control key regenerative responses of human gingival and periodontal ligament fibroblasts. | Journal of periodontology 20090801 |
| Evaluation of alpha7 nicotinic acetylcholine receptor agonists and positive allosteric modulators using the parallel oocyte electrophysiology test station. | Assay and drug development technologies 20090801 |
| Effects of CAY10404 on the PKB/Akt and MAPK pathway and apoptosis in non-small cell lung cancer cells. | Respirology (Carlton, Vic.) 20090801 |
| Wicket spikes misinterpreted as focal abnormalities in idiopathic generalized epilepsy with prescription of carbamazepine leading to paradoxical aggravation. | Neurophysiologie clinique = Clinical neurophysiology 20090801 |
| [Endothelin-receptor antagonists in therapy of pulmonary arterial hypertension]. | Deutsche medizinische Wochenschrift (1946) 20090801 |
| Immunosuppressants: JC virus encephalopathy. Rare but fatal. | Prescrire international 20090801 |
| Design and synthesis of 3,5-diarylisoxazole derivatives as novel class of anti-hyperglycemic and lipid lowering agents. | Bioorganic & medicinal chemistry 20090715 |
| Danazol for uterine fibroids. | The Cochrane database of systematic reviews 20090708 |
| Prolonged opportunity for neuroprotection in experimental stroke with selective blockade of cyclooxygenase-2 activity. | Brain research 20090707 |
| Synthesis of the isoxazolo[4,3,2-de]phenanthridinone moiety of the parnafungins. | Organic letters 20090702 |
| Leflunomide and its metabolite A771726 are high affinity substrates of BCRP: implications for drug resistance. | Annals of the rheumatic diseases 20090701 |
| Negative effects of parecoxib and indomethacin on tendon healing: an experimental study in rats. | Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA 20090701 |
| Role of sorption and degradation in the herbicidal function of isoxaflutole. | Pest management science 20090701 |
| Simultaneous estimation of four proton pump inhibitors--lansoprazole, omeprazole, pantoprazole and rabeprazole: development of a novel generic HPLC-UV method and its application to clinical pharmacokinetic study. | Biomedical chromatography : BMC 20090701 |
| Molecular basis for reduced estrone sulfate transport and altered modulator sensitivity of transmembrane helix (TM) 6 and TM17 mutants of multidrug resistance protein 1 (ABCC1). | Drug metabolism and disposition: the biological fate of chemicals 20090701 |
| Compensatory induction of liver efflux transporters in response to ANIT-induced liver injury is impaired in FXR-null mice. | Toxicological sciences : an official journal of the Society of Toxicology 20090701 |
| Impact of psychotic relapse definitions in assessing drug efficacy and costs: comparison of quetiapine XR, olanzapine and paliperidone ER. | Current medical research and opinion 20090701 |
| Synthesis and antinociceptive activity of pyrazolyl isoxazolines and pyrazolyl isoxazoles. | Bioorganic & medicinal chemistry letters 20090701 |
| Management of RA medications in pregnant patients. | Nature reviews. Rheumatology 20090701 |
| [The role of the neuromodulators in the preventive treatment of migraine]. | Revista de neurologia 20090701 |
| Efficacy of subacromial ropivacaine infusion for rotator cuff surgery. A randomized trial. | The Journal of bone and joint surgery. American volume 20090701 |
| The effects of paroxetine on the pharmacokinetics of paliperidone extended-release tablets. | Pharmacopsychiatry 20090701 |
| [A clinical study of leflunomide and methotrexate therapy in psoriatic arthritis]. | Zhonghua nei ke za zhi 20090701 |
| 1-(3-Phenyl-isoxazol-5-yl)cyclo-hexane-1,2-diol. | Acta crystallographica. Section E, Structure reports online 20090701 |
| N-Phenyl-4-(8-phenyl-4,5-dihydro-1,2-benzoxazolo[4,5-d]thia-zol-2-yl)piperidine-1-carboxamide. | Acta crystallographica. Section E, Structure reports online 20090701 |
| Simple conversion of enamines to 2H-azirines and their rearrangements under thermal conditions. | Organic letters 20090618 |
| Co-administration of a D-amino acid oxidase inhibitor potentiates the efficacy of D-serine in attenuating prepulse inhibition deficits after administration of dizocilpine. | Biological psychiatry 20090615 |
| Stability of zonisamide in extemporaneously compounded oral suspensions. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20090615 |
| Providing patients with information about disease-modifying anti-rheumatic drugs: Individually or in groups? A pilot randomized controlled trial comparing adherence and satisfaction. | Musculoskeletal care 20090601 |
| Preliminary study on the immunologic background of good clinical outcome in rheumatoid arthritis patients after one month therapy with leflunomide. | Rheumatology international 20090601 |
| Dissociating anxiolytic and sedative effects of GABAAergic drugs using temperature and locomotor responses to acute stress. | Psychopharmacology 20090601 |
| The behavior of clomazone in the soil environment. | Pest management science 20090601 |
| Interaction of acenocoumarol and sitaxentan in pulmonary arterial hypertension. | European journal of clinical investigation 20090601 |
| A review of STRIDE-2 and STRIDE-2X: the case for selective endothelin receptor blockade. | European journal of clinical investigation 20090601 |
| Effects of the CYP2D6*10 alleles and co-medication with CYP2D6-dependent drugs on risperidone metabolism in patients with schizophrenia. | Human psychopharmacology 20090601 |
| Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064. | Bioorganic & medicinal chemistry letters 20090601 |
| Randomized, double-blind, placebo-controlled study of paliperidone extended-release and quetiapine in inpatients with recently exacerbated schizophrenia. | The American journal of psychiatry 20090601 |
| Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: effects on HDAC biology and antiproliferative activity. | Bioorganic & medicinal chemistry letters 20090601 |
| Effects of CYP2D6 and CYP3A5 genotypes on the plasma concentrations of risperidone and 9-hydroxyrisperidone in Korean schizophrenic patients. | Journal of clinical psychopharmacology 20090601 |
| Differentiated CaCo-2 cells as an in-vitro model to evaluate de-novo apolipoprotein A-I production in the small intestine. | European journal of gastroenterology & hepatology 20090601 |
| Parecoxib inhibits apoptosis in acute myocardial infarction due to permanent coronary ligation but not due to ischemia-reperfusion. | Journal of cardiovascular pharmacology 20090601 |
| Successful up-front combination therapy in a patient with idiopathic pulmonary hypertension and patent foramen ovale: an alternative to epoprostenol therapy? | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20090601 |
| Severe hepatitis associated with sitaxentan and response to glucocorticoid therapy. | The European respiratory journal 20090601 |
| Sensitization of human hepatic stellate cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by leflunomide. | Biological & pharmaceutical bulletin 20090601 |
| Newer therapies for vasculitis. | Best practice & research. Clinical rheumatology 20090601 |
| Small-molecule endothelin receptor antagonists: a review of patenting activity across therapeutic areas. | IDrugs : the investigational drugs journal 20090601 |
| Cutaneous ulceration induced by leflunomide in a psoriatic patient. | International journal of dermatology 20090601 |
| The effect of Malononitrilamides (FK778) on phenotypic properties of human peripheral dendritic cells. | Transplantation proceedings 20090601 |
| Applicability of a genetic signature for enhanced iloperidone efficacy in the treatment of schizophrenia. | The Journal of clinical psychiatry 20090601 |
| Synthesis and immunomodulation of human lymphocyte proliferation and cytokine (interferon-gamma) production of four novel malonitrilamides. | Chemical biology & drug design 20090601 |
| Bioequivalence of zonisamide orally dispersible tablet and immediate-release capsule formulations: results from two open-label, randomized-sequence, single-dose, two-period, two-treatment crossover studies in healthy male volunteers. | Clinical therapeutics 20090601 |
| 3-(10-Chloro-9-anthr-yl)-5-[3-(prop-2-yn-yloxy)phenoxy-meth-yl]isoxazole. | Acta crystallographica. Section E, Structure reports online 20090601 |
| Paliperidone suppresses the development of the aggressive phenotype in a developmentally sensitive animal model of escalated aggression. | Psychopharmacology 20090501 |
| Effects of cyclooxygenase inhibition on anastomotic healing following large bowel resection in a rabbit model--a randomized, blinded, placebo-controlled trial. | International journal of colorectal disease 20090501 |
| Knockdown of ATP8B1 expression leads to specific downregulation of the bile acid sensor FXR in HepG2 cells: effect of the FXR agonist GW4064. | American journal of physiology. Gastrointestinal and liver physiology 20090501 |
| Inhibition of MptpB phosphatase from Mycobacterium tuberculosis impairs mycobacterial survival in macrophages. | The Journal of antimicrobial chemotherapy 20090501 |
| Regulation of light's action in the mammalian circadian clock: role of the extrasynaptic GABAA receptor. | American journal of physiology. Regulatory, integrative and comparative physiology 20090501 |
| Natural impacted freshwaters: in situ use of alginate immobilized algae to the assessment of algal response. | Ecotoxicology (London, England) 20090501 |
| Identification of an N-oxide pyridine GW4064 analog as a potent FXR agonist. | Bioorganic & medicinal chemistry letters 20090501 |
| Akathisia and second-generation antipsychotic drugs. | Current opinion in psychiatry 20090501 |
| Progressive multifocal leukoencephalopathy, a review and an extended report of five patients with different immune compromised states. | European journal of internal medicine 20090501 |
| Zonisamide increases dopamine turnover in the striatum of mice and common marmosets treated with MPTP. | Journal of pharmacological sciences 20090501 |
| PAR-1622 is a selective peroxisome proliferator-activated receptor gamma partial activator with preserved antidiabetic efficacy and broader safety profile for fluid retention. | Archives of pharmacal research 20090501 |
| The effects of agonists of ionotropic GABA(A) and metabotropic GABA(B) receptors on learning. | The Spanish journal of psychology 20090501 |
| Possible mechanism for zonisamide-induced hyperammonemia in a child with citrullinemia type 1. | Indian journal of medical sciences 20090501 |
| 4-(4-Methoxy-phen-yl)-3-methyl-1,6-di-oxa-2,8-diaza-s-indacen-5(7H)-one. | Acta crystallographica. Section E, Structure reports online 20090501 |
| 3-(6-Benz-yloxy-2,2-dimethyl-perhydro-furo[2,3-d][1,3]dioxol-5-yl)-5-(4-bromo-phen-yl)-2-phenyl-perhydro-pyrrolo[3,4-d]isoxazole-4,6-dione. | Acta crystallographica. Section E, Structure reports online 20090501 |
| Efficacy of perioperative parecoxib injection on postoperative pain relief after laparoscopic cholecystectomy: a prospective, randomized study. | World journal of gastroenterology 20090428 |
| Effects of zonisamide on neurotransmitter release associated with inositol triphosphate receptors. | Neuroscience letters 20090417 |
| Quantitative microdialysis using modified ultraslow microdialysis: direct rapid and reliable determination of free brain concentrations with the MetaQuant technique. | Journal of neuroscience methods 20090415 |
| Intravenous or intramuscular parecoxib for acute postoperative pain in adults. | The Cochrane database of systematic reviews 20090415 |
| Accelerative effect of leflunomide on recovery from hepatic fibrosis involves TRAIL-mediated hepatic stellate cell apoptosis. | Life sciences 20090410 |
| Structure-activity relationships for a series of quinoline-based compounds active against replicating and nonreplicating Mycobacterium tuberculosis. | Journal of medicinal chemistry 20090409 |
| The role of interleukin-6 in lipopolysaccharide-induced fever by mechanisms independent of prostaglandin E2. | Endocrinology 20090401 |
| Secondary delusional parasitosis treated with paliperidone. | Clinical and experimental dermatology 20090401 |
| Influence of parecoxib (cox-2 inhibitor) in experimental pleurodesis. | Respiratory medicine 20090401 |
| The impact of zonisamide on weight. A clinical study in 103 patients with epilepsy. | Acta neurologica Scandinavica 20090401 |
| [Modulation of cortical pain processing by cyclooxygenase inhibition: a functional MRI study]. | Schmerz (Berlin, Germany) 20090401 |
| An agonist-antagonist interaction model for prolactin release following risperidone and paliperidone treatment. | Clinical pharmacology and therapeutics 20090401 |
| Cyclooxygenase 2 inhibition suppresses tubuloglomerular feedback: roles of thromboxane receptors and nitric oxide. | American journal of physiology. Renal physiology 20090401 |
| Inhibiting the teratogenicity of the immunosuppressant leflunomide in mice by supplementation of exogenous uridine. | Toxicological sciences : an official journal of the Society of Toxicology 20090401 |
| [New antiepileptic drugs]. | La Revue de medecine interne 20090401 |
| Evidence for lysophosphatidic acid 1 receptor signaling in the early phase of neuropathic pain mechanisms in experiments using Ki-16425, a lysophosphatidic acid 1 receptor antagonist. | Journal of neurochemistry 20090401 |
| Positive allosteric modulation of the human cannabinoid (CB) receptor by RTI-371, a selective inhibitor of the dopamine transporter. | British journal of pharmacology 20090401 |
| A fluorinated analog of ISO-1 blocks the recognition and biological function of MIF and is orally efficacious in a murine model of colitis. | European journal of pharmacology 20090401 |
| Topiramate and zonisamide prevent paradoxical intoxication induced by carbamazepine and phenytoin. | Epilepsy research 20090401 |
| Evaluation of the Hsp90 inhibitor NVP-AUY922 in multicellular tumour spheroids with respect to effects on growth and PET tracer uptake. | Nuclear medicine and biology 20090401 |
| Improved myocardial protection in the failing heart by selective endothelin-A receptor blockade. | The Journal of thoracic and cardiovascular surgery 20090401 |
| An elderly man with rheumatoid arthritis and dyspnea. | Chest 20090401 |
| [Leflunomide and Lyell syndrome]. | Annales de dermatologie et de venereologie 20090401 |
| [Pharmacologic treatment of Parkinson disease]. | Brain and nerve = Shinkei kenkyu no shinpo 20090401 |
| A 50-year-old man with stage 2 sarcoidosis with pleural involvement. | Journal of hospital medicine 20090401 |
| The effects of PDTC plus leflunomide and cyclosporine on the NF-kappaB signaling pathway in mouse-to-rat cardiac xenografts. | Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20090401 |
| Dimethyl cis-2-methyl-3-p-tolyl-isoxazolidine-4,5-dicarboxyl-ate. | Acta crystallographica. Section E, Structure reports online 20090401 |
| 2-Methyl-3-(5-methyl-2-thien-yl)-5-phenyl-perhydro-pyrrolo[3,4-d]isoxazole-4,6-dione. | Acta crystallographica. Section E, Structure reports online 20090401 |
| 5-(1-Cyclo-hexen-1-yl)-3-(4-methoxy-phen-yl)isoxazole. | Acta crystallographica. Section E, Structure reports online 20090401 |
| Crystal structure of acivicin-inhibited gamma-glutamyltranspeptidase reveals critical roles for its C-terminus in autoprocessing and catalysis. | Biochemistry 20090324 |
| Synthesis and herbicidal activities of novel 4-(4-(5-methyl-3-arylisoxazol-4-yl)thiazol-2-yl)piperidyl carboxamides and thiocarboxamides. | Molecules (Basel, Switzerland) 20090324 |
| The versatile electrophilic reactivity of 4,6-dinitrobenzo[d]isoxazole-3-carbonitrile. | Organic & biomolecular chemistry 20090321 |
| TRPC1 associates with BK(Ca) channel to form a signal complex in vascular smooth muscle cells. | Circulation research 20090313 |
| Synthesis of thiazolo- and 7,8-dihydrothiazolo[4,5-e]benzoisoxazoles. | Journal of combinatorial chemistry 20090309 |
| Eisenmenger syndrome a clinical perspective in a new therapeutic era of pulmonary arterial hypertension. | Journal of the American College of Cardiology 20090303 |
| Progress in the discovery of selective, high affinity A(2B) adenosine receptor antagonists as clinical candidates. | Purinergic signalling 20090301 |
| Selective P2X(7) receptor antagonists for chronic inflammation and pain. | Purinergic signalling 20090301 |
| Case-control analysis of ambulance, emergency room, or inpatient hospital events for epilepsy and antiepileptic drug formulation changes. | Epilepsia 20090301 |
| Synthesis of alkenyldiarylmethanes (ADAMs) containing benzo[d]isoxazole and oxazolidin-2-one rings, a new series of potent non-nucleoside HIV-1 reverse transcriptase inhibitors. | European journal of medicinal chemistry 20090301 |
| Identification of steroid isoxazole isomers marketed as designer supplement. | Steroids 20090301 |
| LPA1 receptors mediate stimulation, whereas LPA2 receptors mediate inhibition, of migration of pancreatic cancer cells in response to lysophosphatidic acid and malignant ascites. | Carcinogenesis 20090301 |
| [Leg ulcer in mixed connective tissue disease. Resolution during sitaxsentan therapy]. | Zeitschrift fur Rheumatologie 20090301 |
| [Leflunomide in combination with TNF-blockers for Methotrexate intolerance]. | Zeitschrift fur Rheumatologie 20090301 |
| Cellular growth inhibition by FK778 is linked to G1 arrest or S phase accumulation, dependent on the functional status of the retinoblastoma protein. | International journal of molecular medicine 20090301 |
| Sensitivity of older patients to antipsychotic motor side effects: a PET study examining potential mechanisms. | The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 20090301 |
| Critical periods for the teratogenicity of immune-suppressant Leflunomide in mice. | Congenital anomalies 20090301 |
| Involvement of breast cancer resistance protein expression on rheumatoid arthritis synovial tissue macrophages in resistance to methotrexate and leflunomide. | Arthritis and rheumatism 20090301 |
| [Effect of disease modifying anti-rheumatic drugs on radiographic progression in rheumatoid arthritis]. | Clinical calcium 20090301 |
| Efficacy and tolerability of zonisamide in idiopathic generalized epilepsy. | Epileptic disorders : international epilepsy journal with videotape 20090301 |
| [Immunosuppressants]. | Nihon rinsho. Japanese journal of clinical medicine 20090301 |
| Increased prevalence of polyomavirus BK viruria that correlates with thrombocytopenia in patients with systemic lupus erythematosus on intensive immunosuppressive therapy. | Autoimmunity 20090301 |
| Inhibition of thalamic excitability by 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-ol: a selective role for delta-GABA(A) receptors. | The European journal of neuroscience 20090301 |
| Paliperidone in an adult patient with Asperger syndrome: case report. | Pharmacopsychiatry 20090301 |
| Expected clinical benefits of paliperidone extended-release formulation when compared with risperidone immediate-release. | Expert opinion on drug delivery 20090301 |
| Positive modulation of alpha7 nAChR responses in rat hippocampal interneurons to full agonists and the alpha7-selective partial agonists, 4OH-GTS-21 and S 24795. | Neuropharmacology 20090301 |
| [Financial cost of early rheumatoid arthritis in the first year of medical attention: three clinical scenarios in a third-tier university hospital in Colombia]. | Biomedica : revista del Instituto Nacional de Salud 20090301 |
| Characterization of compounds on nicotinic acetylcholine receptor alpha7 channels using higher throughput electrophysiology. | Journal of neuroscience methods 20090215 |
| Zonisamide for essential tremor: an evaluator-blinded study. | Movement disorders : official journal of the Movement Disorder Society 20090215 |
| Synthesis of 5-isoxazol-5-yl-2'-deoxyuridines exhibiting antiviral activity against HSV and several RNA viruses. | Bioorganic & medicinal chemistry letters 20090215 |
| Design, synthesis and biological evaluation of a novel class of anticancer agents: anthracenylisoxazole lexitropsin conjugates. | Bioorganic & medicinal chemistry 20090215 |
| ATP competitive inhibitors of D-alanine-D-alanine ligase based on protein kinase inhibitor scaffolds. | Bioorganic & medicinal chemistry 20090201 |
| Expanding the repertoire of small molecule transcriptional activation domains. | Bioorganic & medicinal chemistry 20090201 |
| Interleukin-13 augments bronchial smooth muscle contractility with an up-regulation of RhoA protein. | American journal of respiratory cell and molecular biology 20090201 |
| Ultrasound promoted synthesis of substituted pyrazoles and isoxazoles containing sulphone moiety. | Ultrasonics sonochemistry 20090201 |
| COX-2 inhibition attenuates endotoxin-induced downregulation of organic anion transporters in the rat renal cortex. | Kidney international 20090201 |
| Pharmacological analysis of the novel, rapid, and potent inactivation of the human 5-Hydroxytryptamine7 receptor by risperidone, 9-OH-Risperidone, and other inactivating antagonists. | Molecular pharmacology 20090201 |
| Desensitization of nicotinic acetylcholine receptors as a strategy for drug development. | The Journal of pharmacology and experimental therapeutics 20090201 |
| Local and global calcium signals associated with the opening of neuronal alpha7 nicotinic acetylcholine receptors. | Cell calcium 20090201 |
| Caffeic acid, a phenolic phytochemical in coffee, directly inhibits Fyn kinase activity and UVB-induced COX-2 expression. | Carcinogenesis 20090201 |
| Zonisamide in children and young adults with refractory epilepsy: an open label, multicenter Italian study. | Epilepsy research 20090201 |
| Metabolism and renal elimination of gaboxadol in humans: role of UDP-glucuronosyltransferases and transporters. | Pharmaceutical research 20090201 |
| Tolerability, pharmacokinetics and night-time effects on postural sway and critical flicker fusion of gaboxadol and zolpidem in elderly subjects. | British journal of clinical pharmacology 20090201 |
| Zonisamide block of cloned human T-type voltage-gated calcium channels. | Epilepsy research 20090201 |
| Pharmaceutical metabolite profiling using quadrupole/ion mobility spectrometry/time-of-flight mass spectrometry. | Rapid communications in mass spectrometry : RCM 20090201 |
| Dihydroorotate dehydrogenase inhibitor A771726 (leflunomide) induces apoptosis and diminishes proliferation of multiple myeloma cells. | Molecular cancer therapeutics 20090201 |
| Survival in pulmonary hypertension associated with the scleroderma spectrum of diseases: impact of interstitial lung disease. | Arthritis and rheumatism 20090201 |
| Disease-modifying antirheumatic drugs. | The Journal of hand surgery 20090201 |
| The effect of parecoxib and indometacin on tendon-to-bone healing in a bone tunnel: an experimental study in rats. | The Journal of bone and joint surgery. British volume 20090201 |
| Reliability, validity and ability to detect change of the clinician-rated Personal and Social Performance scale in patients with acute symptoms of schizophrenia. | Current medical research and opinion 20090201 |
| Bioequivalence evaluation of two strengths of risperidone tablet formulations in healthy volunteers. | International journal of clinical pharmacology and therapeutics 20090201 |
| The effect of exon (19C>A) dihydroorotate dehydrogenase gene polymorphism on rheumatoid arthritis treatment with leflunomide. | Pharmacogenomics 20090201 |
| Leflunomide use in New Zealand. A national prospective post-marketing study. | Internal medicine journal 20090201 |
| Pharmacology of alpha7 nicotinic acetylcholine receptor mediated extracellular signal-regulated kinase signalling in PC12 cells. | British journal of pharmacology 20090201 |
| New analogues of epiboxidine incorporating the 4,5-dihydroisoxazole nucleus: synthesis, binding affinity at neuronal nicotinic acetylcholine receptors, and molecular modeling investigations. | Chemistry & biodiversity 20090201 |
| In-vitro relationship between protein-binding and free drug concentrations of a water-soluble selective beta-adrenoreceptor antagonist (atenolol) and its interaction with arsenic. | Journal of health, population, and nutrition 20090201 |
| Curcumin as a possible lead compound against hormone-independent, multidrug-resistant breast cancer. | Annals of the New York Academy of Sciences 20090201 |
| Successful switch to sitaxsentan in a patient with HIV-related pulmonary arterial hypertension and late intolerance to nonselective endothelin receptor blockade. | Therapeutic advances in respiratory disease 20090201 |
| [Psychiatry]. | Revue medicale suisse 20090114 |
| The effectiveness of leflunomide as a co-therapy of tumour necrosis factor inhibitors in rheumatoid arthritis: a population-based study. | Annals of the rheumatic diseases 20090101 |
| Open-label, long-term safety study of zonisamide administered to children and adolescents with epilepsy. | European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 20090101 |
| The effectiveness of two COX-2 inhibitors in the prophylaxis against heterotopic new bone formation: an experimental study in rabbits. | The Journal of surgical research 20090101 |
| The changes in serum chemokines following leflunomide therapy in patients with rheumatoid arthritis. | Clinical rheumatology 20090101 |
| Effects of zonisamide on c-Fos expression under conditions of tacrine-induced tremulous jaw movements in rats: a potential mechanism underlying its anti-parkinsonian tremor effect. | Parkinsonism & related disorders 20090101 |
| Effects of leflunomide and methotrexate in rheumatoid arthritis detected by digital X-ray radiogrammetry and computer-aided joint space analysis. | Rheumatology international 20090101 |
| Ambrisentan therapy in patients with pulmonary arterial hypertension who discontinued bosentan or sitaxsentan due to liver function test abnormalities. | Chest 20090101 |
| Lysophosphatic acid modulates prostaglandin secretion in the bovine uterus. | Reproduction (Cambridge, England) 20090101 |
| New pleconaril and [(biphenyloxy)propyl]isoxazole derivatives with substitutions in the central ring exhibit antiviral activity against pleconaril-resistant coxsackievirus B3. | Antiviral research 20090101 |
| Zonisamide for migraine prophylaxis in patients refractory to topiramate. | Clinical neuropharmacology 20090101 |
| Mechanisms underlying cognitive enhancement and reversal of cognitive deficits in nonhuman primates by the ampakine CX717. | Psychopharmacology 20090101 |
| Next-day residual effects of gaboxadol and flurazepam administered at bedtime: a randomized double-blind study in healthy elderly subjects. | Human psychopharmacology 20090101 |
| Macrophage migration inhibitory factor promotes colorectal cancer. | Molecular medicine (Cambridge, Mass.) 20090101 |
| The new immunosuppressive agent FK778 attenuates neointima formation in an experimental venous bypass graft model. | Vascular pharmacology 20090101 |
| Chronic stimulation of farnesoid X receptor impairs nitric oxide sensitivity of vascular smooth muscle. | American journal of physiology. Heart and circulatory physiology 20090101 |
| Synthesis and evaluation of electron-rich curcumin analogues. | Bioorganic & medicinal chemistry 20090101 |
| Parecoxib for analgesia after craniotomy. | British journal of anaesthesia 20090101 |
| Photoinduced degradation of the herbicide clomazone model reactions for natural and technical systems. | Photochemistry and photobiology 20090101 |
| Intracellular mechanisms underlying the nicotinic enhancement of LTP in the rat dentate gyrus. | The European journal of neuroscience 20090101 |
| Update on medication-induced peripheral neuropathy. | Current neurology and neuroscience reports 20090101 |
| Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression. | Hepatology (Baltimore, Md.) 20090101 |
| Cardiovascular safety of the cyclooxygenase-2 selective inhibitors parecoxib and valdecoxib in the postoperative setting: an analysis of integrated data. | Anesthesia and analgesia 20090101 |
| Glomerular filtration rate after tramadol, parecoxib and pindolol following anaesthesia and analgesia in comparison with morphine in dogs. | Veterinary anaesthesia and analgesia 20090101 |
| Berberine exerts neuroprotective actions against in vitro ischemia-induced neuronal cell damage in organotypic hippocampal slice cultures: involvement of B-cell lymphoma 2 phosphorylation suppression. | Biological & pharmaceutical bulletin 20090101 |
| Combination treatment with leflunomide and methotrexate for patients with active rheumatoid arthritis. | Scandinavian journal of rheumatology 20090101 |
| The effect of selective cyclooxygenase-2 inhibitor on human osteoclast precursors to influence osteoclastogenesis in vitro. | Modern rheumatology 20090101 |
| Synthesis of some new isoxazoline derivatives as possible anti-Candida agents. | Acta poloniae pharmaceutica 20090101 |
| [Synthesis of electroconductive polyaniline using immobilized laccase]. | Prikladnaia biokhimiia i mikrobiologiia 20090101 |
| [Role of monotherapy with new antiepileptic drugs in the treatment of childhood epilepsy]. | Medicina 20090101 |
| A randomized, double-blind, placebo-controlled study of preemptively administered intravenous parecoxib: effect on anxiety levels and procedural pain during epidural catheter placement for surgical operations or for chronic pain therapy. | Pain practice : the official journal of World Institute of Pain 20090101 |
| Sex hormones modulate the effects of Leflunomide on cytokine production by cultures of differentiated monocyte/macrophages and synovial macrophages from rheumatoid arthritis patients. | Journal of autoimmunity 20090101 |
| Double-blind, placebo-controlled, multiple-ascending-dose study on the pharmacodynamics of ABIO-08/01, a new CNS drug with potential anxiolytic activity. 2. EEG-tomography findings based on LORETA (low-resolution brain electromagnetic tomography). | Neuropsychobiology 20090101 |
| Treatment of Evans' syndrome with human intravenous immunoglobulin and leflunomide in a diabetic dog. | Journal of the American Animal Hospital Association 20090101 |
| Lysophosphatidic acid stimulates cell growth by different mechanisms in SKOV-3 and Caov-3 ovarian cancer cells: distinct roles for Gi- and Rho-dependent pathways. | Pharmacology 20090101 |
| IL-1beta, IL-6, and TNF gene polymorphisms do not affect the treatment outcome of rheumatoid arthritis patients with leflunomide. | Pharmacological reports : PR 20090101 |
| Efficient synthesis of trisubstituted pyrazoles and isoxazoles using a traceless 'catch and release' solid-phase strategy. | Journal of combinatorial chemistry 20090101 |
| The effect of parecoxib on kidney function at laparoscopic hysterectomy. | Renal failure 20090101 |
| Development of mucoadhesive buccal films for the treatment of oral sub-mucous fibrosis: a preliminary study. | Pharmaceutical development and technology 20090101 |
| Elevated serum levels of arachidonoyl-lysophosphatidic acid and sphingosine 1-phosphate in systemic sclerosis. | International journal of medical sciences 20090101 |
| Leflunomide-induced polymyositis in a patient with rheumatoid arthritis. | Modern rheumatology 20090101 |
| FK778 attenuates cytomegalovirus-enhanced vein graft intimal hyperplasia in a rat model. | Intervirology 20090101 |
| Leflunomide treatment in elderly patients with rheumatoid or psoriatic arthritis: retrospective analysis of safety and adherence to treatment. | Drugs & aging 20090101 |
| Oral therapies for the treatment of pulmonary arterial hypertension: a population-based cost-minimization analysis. | Applied health economics and health policy 20090101 |
| Leflunomide. | Indian journal of dermatology, venereology and leprology 20090101 |
| Long-term efficacy of leflunomide on disease activity and inhibition of joint damage: retrospective comparison with methotrexate for Japanese rheumatoid arthritis patients. | Modern rheumatology 20090101 |
| The anticonvulsant zonisamide reduces ethanol self-administration by risky drinkers. | The American journal of drug and alcohol abuse 20090101 |
| Idiopathic hemifacial spasm responsive to zonisamide: a case report. | Clinical neuropharmacology 20090101 |
| Base induced chemical conversion of 3-carbamoyl-2-isoxazolines. | Journal of oleo science 20090101 |
| [Rituximab treatment of rheumatoid arthritis: new evidence]. | Terapevticheskii arkhiv 20090101 |
| Reduction in opioid-related adverse events and improvement in function with parecoxib followed by valdecoxib treatment after non-cardiac surgery: a randomized, double-blind, placebo-controlled, parallel-group trial. | Clinical drug investigation 20090101 |
| Effects of prophylactic administration of bacteriophages to immunosuppressed mice infected with Staphylococcus aureus. | BMC microbiology 20090101 |
| Leflunomide therapy for polyomavirus-induced allograft nephropathy: efficient BK virus elimination without increased risk of rejection. | Transplantation proceedings 20090101 |
| Identification of the specific binding proteins of bioactive small compound using affinity resins. | Methods in molecular biology (Clifton, N.J.) 20090101 |
| Population pharmacokinetics of intramuscular paliperidone palmitate in patients with schizophrenia: a novel once-monthly, long-acting formulation of an atypical antipsychotic. | Clinical pharmacokinetics 20090101 |
| Paliperidon mediated modification of cortical inhibition. | Neuro endocrinology letters 20090101 |
| Benefit-risk assessment of leflunomide: an appraisal of leflunomide in rheumatoid arthritis 10 years after licensing. | Drug safety 20090101 |
| Role of macrophage migration inhibitory factor in influenza H5N1 virus pneumonia. | Acta virologica 20090101 |
| Antipsychotic induced catatonia: a case of probable dementia with Lewy bodies. | The Journal of neuropsychiatry and clinical neurosciences 20090101 |
| [Treatment with paliperidone extended-release tablets in a case of resistant undifferentiated schizophrenia: clinical improvement with 12 mg and evaluation through 3TRE scale]. | Rivista di psichiatria 20090101 |
| The economic burden of biological therapy in rheumatoid arthritis in clinical practice: cost-effectiveness analysis of sub-cutaneous anti-TNFalpha treatment in Italian patients. | International journal of immunopathology and pharmacology 20090101 |
| A comprehensive review of immunosuppression used for liver transplantation. | Journal of transplantation 20090101 |
| The influence of agonists of GABA(A) and GABA(B) receptors on the formation of the defensive and inhibitory conditioned reflexes. | Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 20090101 |
| [Lichen planus-like eruption. Case report]. | Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20090101 |
| DPRESS: Localizing estimates of predictive uncertainty. | Journal of cheminformatics 20090101 |
| Synthesis, Antiinflammatory and Antibacterial Activity of Novel Indolyl-isoxazoles. | Indian journal of pharmaceutical sciences 20090101 |
| [Systematic review to assess the effectiveness and safety of parecoxib]. | Acta ortopedica mexicana 20090101 |
| Pregnancy course and neonatal outcome after exposure to leflunomide--2 cases report and review of literature. | Przeglad lekarski 20090101 |
| Ethyl 4-{1-[(2,4-dinitro-phen-yl)hydrazono]eth-yl}-5-(2-naphthyl-methoxy-meth-yl)isoxazole-3-carboxyl-ate. | Acta crystallographica. Section E, Structure reports online 20090101 |
| Suppression of immunoglobulin production by a novel dihydroorotate dehydrogenase inhibitor, S-2678. | European journal of pharmacology 20081228 |
| Study of the complexation of risperidone and 9-hydroxyrisperidone with cyclodextrin hosts using affinity capillary electrophoresis and (1)H NMR spectroscopy. | Journal of chromatography. A 20081226 |
| Click azide-nitrile cycloaddition as a new ligation tool for the synthesis of tetrazole-tethered C-glycosyl alpha-amino acids. | The Journal of organic chemistry 20081219 |
| Sequential organocatalyzed Michael addition/[3 + 2]-heterocyclization for the stereoselective synthesis of fused-isoxazoline precursors of enantiopure cyclopentanoids. | Organic letters 20081204 |
| Cyclooxygenase 2 pathway and its therapeutic inhibition in superantigen-induced toxic shock. | Shock (Augusta, Ga.) 20081201 |
| [Zonisamide as add-on treatment for focal epilepsies. An outcome analysis of 74 patients]. | Der Nervenarzt 20081201 |
| Predicting possible zonisamide hypersensitivity syndrome. | Experimental dermatology 20081201 |
| Temperature and water pressure head effects on the degradation of the diketonitrile metabolite of isoxaflutole in a loamy soil under two tillage systems. | Environmental pollution (Barking, Essex : 1987) 20081201 |
| Rheumatoid arthritis, alcohol, leflunomide and methotrexate. Can changes to the BSR guidelines for leflunomide and methotrexate on alcohol consumption be justified? | Musculoskeletal care 20081201 |
| Comparison of the novel subtype-selective GABAA receptor-positive allosteric modulator NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile] with diazepam, zolpidem, bretazenil, and gaboxadol in rat models of inflammatory and neuropathic pain. | The Journal of pharmacology and experimental therapeutics 20081201 |
| COX-2 expression and function in the hyperalgesic response to paw inflammation in mice. | Prostaglandins, leukotrienes, and essential fatty acids 20081201 |
| Biochemical effects of clomazone herbicide on piava (Leporinus obtusidens). | Chemosphere 20081201 |
| Disposition and safety of zonisamide after intravenous and oral single dose and oral multiple dosing in normal hound dogs. | Journal of veterinary pharmacology and therapeutics 20081201 |
| The disparity of pharmacokinetics and prolactin study for risperidone long-acting injection. | Journal of clinical psychopharmacology 20081201 |
| What are the nursing implications when using paliperidone prolonged release for people with schizophrenia. | Journal of psychiatric and mental health nursing 20081201 |
| DMARDS and infections in rheumatoid arthritis. | Autoimmunity reviews 20081201 |
| A pair of twins born after maternal exposure to leflunomide. | Journal of perinatology : official journal of the California Perinatal Association 20081201 |
| Is leflunomide effective in the treatment of psoriasis in a patient who is unable to benefit from standard first- and second-line therapies and needs an affordable treatment option? | Archives of dermatology 20081201 |
| The reaction of beta-amino-alpha,gamma-dicyanocrotononitrile with acetophenone: synthesis of pyridine, pyridazine and thiophene derivatives with antimicrobial activities. | Acta pharmaceutica (Zagreb, Croatia) 20081201 |
| The farnesoid X receptor (FXR) as a new target in non-alcoholic steatohepatitis. | Diabetes & metabolism 20081201 |
| [Update in treatment of psoriatic arthritis]. | La Tunisie medicale 20081201 |
| Catalytic mechanism and performance of computationally designed enzymes for Kemp elimination. | Journal of the American Chemical Society 20081126 |
| Apparent seizure and atrial fibrillation associated with paliperidone. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20081115 |
| Zonisamide prevents olanzapine-associated hyperphagia, weight gain, and elevated blood glucose in rats. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20081101 |
| Synthesis and pharmacological screening of derivatives of isoxazolo[4,5-d]pyrimidine. | European journal of medicinal chemistry 20081101 |
| Coexistence of familial Mediterranean fever and psoriasis in a patient with seronegative spondyloarthropathy. | Rheumatology international 20081101 |
| FK778 ameliorates post-transplant expression of fibrogenic growth factors and development of chronic rejection changes in rat kidney allografts. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20081101 |
| Treatment emergent mania responding to valproate in a Chinese female adolescent population with eating disorders: a case series. | European eating disorders review : the journal of the Eating Disorders Association 20081101 |
| Tissue transgluaminase 2 expression in meningiomas. | Journal of neuro-oncology 20081101 |
| Alpha-conotoxin Arenatus IB[V11L,V16D] [corrected] is a potent and selective antagonist at rat and human native alpha7 nicotinic acetylcholine receptors. | The Journal of pharmacology and experimental therapeutics 20081101 |
| Effects of zonisamide on isolated head tremor. | European journal of neurology 20081101 |
| Antiepileptic activity of zonisamide on hippocampal CA3 neurons does not depend on carbonic anhydrase inhibition. | Epilepsy research 20081101 |
| Population pharmacokinetic analysis for risperidone using highly sparse sampling measurements from the CATIE study. | British journal of clinical pharmacology 20081101 |
| The active metabolite of leflunomide, A77 1726, protects rat hepatocytes against bile acid-induced apoptosis. | Journal of hepatology 20081101 |
| Efficacy and safety of oral paliperidone extended-release tablets in the treatment of acute schizophrenia: pooled data from three 52-week open-label studies. | International clinical psychopharmacology 20081101 |
| Use of leflunomide in the treatment of polyomavirus BK-associated nephropathy. | The Annals of pharmacotherapy 20081101 |
| [Preventive treatment of chronic migraine with zonisamide: a study in patients who are refractory or intolerant to topiramate]. | Revista de neurologia 20081101 |
| Leflunomide-associated progressive multifocal leukoencephalopathy. | Archives of neurology 20081101 |
| Co-relationship of physical stability of amorphous dispersions with enthalpy relaxation. | Die Pharmazie 20081101 |
| [Therapy of Parkinson's disease--up to date]. | Rinsho shinkeigaku = Clinical neurology 20081101 |
| Neuroprotection of GluR5-containing kainate receptor activation against ischemic brain injury through decreasing tyrosine phosphorylation of N-methyl-D-aspartate receptors mediated by Src kinase. | The Journal of biological chemistry 20081024 |
| 3-amino-7-phthalazinylbenzoisoxazoles as a novel class of potent, selective, and orally available inhibitors of p38alpha mitogen-activated protein kinase. | Journal of medicinal chemistry 20081023 |
| Design, synthesis, and biological evaluation of novel constrained meta-substituted phenyl propanoic acids as peroxisome proliferator-activated receptor alpha and gamma dual agonists. | Journal of medicinal chemistry 20081023 |
| [Antirheumatic agents for treatment of rheumatoid arthritis]. | Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20081010 |
| Paliperidone as a mood stabilizer: a pre-frontal cortex synaptoneurosomal proteomics comparison with lithium and valproic acid after chronic treatment reveals similarities in protein expression. | Brain research 20081003 |
| Responses to clomazone and 5-ketoclomazone by Echinochloa phyllopogon resistant to multiple herbicides in Californian rice fields. | Pest management science 20081001 |
| NMR studies of novel Schiff bases derived from L-alpha-amino methyl esters and 3-hydroxypyridin-4-carboxaldehyde. | Magnetic resonance in chemistry : MRC 20081001 |
| Sitaxsentan for the treatment of pulmonary arterial hypertension: a 1-year, prospective, open-label observation of outcome and survival. | Chest 20081001 |
| ABCB1 polymorphisms influence steady-state plasma levels of 9-hydroxyrisperidone and risperidone active moiety. | Therapeutic drug monitoring 20081001 |
| Impact of multiple inhibitors or substrates of cytochrome P450 2D6 on plasma risperidone levels in patients on polypharmacy. | Therapeutic drug monitoring 20081001 |
| Novel immunological approaches in the treatment of atopic eczema. | Current opinion in allergy and clinical immunology 20081001 |
| Isoxazolo[3,4-b]quinoline-3,4(1H,9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim-2 kinases: chemistry, biological activities, and molecular modeling. | Bioorganic & medicinal chemistry letters 20081001 |
| Stimulatory role of lysophosphatidic acid in cyclooxygenase-2 induction by synovial fluid of patients with rheumatoid arthritis in fibroblast-like synovial cells. | Journal of immunology (Baltimore, Md. : 1950) 20081001 |
| Leflunomide-induced toxic epidermal necrolysis in a patient with rheumatoid arthritis. | Joint, bone, spine : revue du rhumatisme 20081001 |
| [Specific drugs for the treatment of pulmonary arterial hypertension - current status]. | Deutsche medizinische Wochenschrift (1946) 20081001 |
| Paliperidone extended-release for the treatment of schizophrenia. | Pharmacotherapy 20081001 |
| Effect of gaboxadol on sleep in adult and elderly patients with primary insomnia: results from two randomized, placebo-controlled, 30-night polysomnography studies. | Sleep 20081001 |
| Treatment of seizures in a patient with Batten's disease. | The Nurse practitioner 20081001 |
| Optimizing endothelin receptor antagonist use in the management of pulmonary arterial hypertension. | Vascular health and risk management 20081001 |
| Intermolecular cycloaddition of N-boranonitrone with alkenes. | The Journal of organic chemistry 20080919 |
| Proline as Lewis base catalyst: diastereoselective synthesis of isoxazoline-N-oxide through [3 + 2] cycloaddition. | Organic letters 20080918 |
| Discovery of amido-benzisoxazoles as potent c-Kit inhibitors. | Bioorganic & medicinal chemistry letters 20080915 |
| A novel, macrophage migration inhibitory factor suicide substrate inhibits motility and growth of lung cancer cells. | Cancer research 20080915 |
| Lysophosphatidylserine stimulates chemotactic migration in U87 human glioma cells. | Biochemical and biophysical research communications 20080912 |
| Selective ortho methylation of nitroheteroaryls by vicarious nucleophilic substitution. | The Journal of organic chemistry 20080905 |
| Transport of amino acids and GABA analogues via the human proton-coupled amino acid transporter, hPAT1: characterization of conditions for affinity and transport experiments in Caco-2 cells. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20080902 |
| Introducing the first polymer-free leflunomide eluting stent. | Atherosclerosis 20080901 |
| Differential and cell-type specific regulation of responses to Toll-like receptor agonists by ISO-1. | Immunology 20080901 |
| A prospective, randomized, double-blind comparison between parecoxib and ketorolac for early postoperative analgesia following nasal surgery. | Minerva anestesiologica 20080901 |
| [Elevated liver enzymes in rheumatoid arthritis : differential diagnostic considerations based on a case report]. | Zeitschrift fur Rheumatologie 20080901 |
| Genetic polymorphism of CYP1A2 and the toxicity of leflunomide treatment in rheumatoid arthritis patients. | European journal of clinical pharmacology 20080901 |
| Adjunctive anakinra in patients with active rheumatoid arthritis despite methotrexate, or leflunomide, or cyclosporin-A monotherapy: a 48-week, comparative, prospective study. | Rheumatology (Oxford, England) 20080901 |
| Tolerability of methotrexate and leflunomide combination therapy for inflammatory arthritis in routine clinical practice: results of a four-centre study. | Rheumatology (Oxford, England) 20080901 |
| The non-steroidal anti-inflammatory drugs protect mouse cochlea against acoustic injury. | The Tohoku journal of experimental medicine 20080901 |
| Choreatic symptoms during and after treatment with paliperidone and escitalopram. | Pharmacopsychiatry 20080901 |
| Therapeutic role of zonisamide in neuropsychiatric disorders. | Mini reviews in medicinal chemistry 20080901 |
| Prevention of acetaminophen (APAP)-induced hepatotoxicity by leflunomide via inhibition of APAP biotransformation to N-acetyl-p-benzoquinone imine. | Toxicology letters 20080828 |
| [Paliperidone--a novel second-generation antipsychotic]. | Ugeskrift for laeger 20080825 |
| Epiboxidine and novel-related analogues: a convenient synthetic approach and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes. | Bioorganic & medicinal chemistry letters 20080815 |
| Efficient synthesis and utilization of phenyl-substituted heteroaromatic carboxylic acids as aryl diketo acid isosteres in the design of novel HIV-1 integrase inhibitors. | Bioorganic & medicinal chemistry letters 20080815 |
| Novel terphenyls and 3,5-diaryl isoxazole derivatives endowed with growth supporting and antiapoptotic properties. | Journal of medicinal chemistry 20080814 |
| Synthesis of GABAA receptor agonists and evaluation of their alpha-subunit selectivity and orientation in the GABA binding site. | Journal of medicinal chemistry 20080814 |
| Serotonin mediates PGE2 overexpression through 5-HT2A and 5-HT3 receptor subtypes in serum-free tissue culture of macrophage-like synovial cells. | Rheumatology international 20080801 |
| Pharmacokinetics and toxicity of zonisamide in cats. | Journal of feline medicine and surgery 20080801 |
| Leflunomide (Arava) is a useful DMARD in Indian (Asian) patients: a clinic-based observational study of 1-year treatment. | Clinical rheumatology 20080801 |
| Mouse Ae1 E699Q mediates SO42-i/anion-o exchange with [SO42-]i-dependent reversal of wild-type pHo sensitivity. | American journal of physiology. Cell physiology 20080801 |
| Signalling profile and antitumour activity of the novel Hsp90 inhibitor NVP-AUY922 in multiple myeloma. | Leukemia 20080801 |
| Tonically active inhibition selectively controls feedforward circuits in mouse barrel cortex. | Journal of neurophysiology 20080801 |
| Does leflunomide attenuate the sepsis-induced acute lung injury? | Pediatric surgery international 20080801 |
| Approaches to the treatment of early rheumatoid arthritis with disease-modifying antirheumatic drugs. | British journal of clinical pharmacology 20080801 |
| Long-term safety and efficacy of zonisamide in patients with refractory partial-onset epilepsy. | Acta neurologica Scandinavica 20080801 |
| Inhibition of endothelin receptors in the treatment of pulmonary arterial hypertension: does selectivity matter? | European heart journal 20080801 |
| Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064. | Bioorganic & medicinal chemistry letters 20080801 |
| A multiple-day regimen of parecoxib sodium 20 mg twice daily provides pain relief after total hip arthroplasty. | Anesthesia and analgesia 20080801 |
| Population estimation regarding the effects of cytochrome P450 2C19 and 3A5 polymorphisms on zonisamide clearance. | Therapeutic drug monitoring 20080801 |
| Targeting Hsp90: small-molecule inhibitors and their clinical development. | Current opinion in pharmacology 20080801 |
| [Persistent diarrhea and loss of weight during therapy with leflunomide]. | Deutsche medizinische Wochenschrift (1946) 20080801 |
| Lysophosphatidic acid stimulates the proliferation and motility of malignant pleural mesothelioma cells through lysophosphatidic acid receptors, LPA1 and LPA2. | Cancer science 20080801 |
| Severe crescentic BK virus nephropathy with favourable outcome in a transplanted patient treated with Leflunomide. | Clinical nephrology 20080801 |
| Sitaxsentan sodium for pulmonary hypertension. | Drugs of today (Barcelona, Spain : 1998) 20080801 |
| Oxidative bioactivation and toxicity of leflunomide in immortalized human hepatocytes and kinetics of the non-enzymatic conversion to its major metabolite, A77 1726. | Drug metabolism letters 20080801 |
| (3R,3aS,6aR)-2,5-Dimethyl-3-(5-phenyl-2-thien-yl)perhydro-pyrrolo[3,4-d][1,2]oxazole-4,6-dione. | Acta crystallographica. Section E, Structure reports online 20080801 |
| Lysophosphatidylglycerol stimulates chemotactic migration in human natural killer cells. | Biochemical and biophysical research communications 20080718 |
| Synthesis of alpha-trifluoromethyl-beta-lactams and esters of beta-amino acids via 1,3-dipolar cycloaddition of nitrones to fluoroalkenes. | The Journal of organic chemistry 20080718 |
| Synthesis and monoamine transporter binding properties of 2beta-[3'-(substituted benzyl)isoxazol-5-yl]- and 2beta-[3'-methyl-4'-(substituted phenyl)isoxazol-5-yl]-3beta-(substituted phenyl)tropanes. | Bioorganic & medicinal chemistry 20080715 |
| Perinatal alcohol exposure leads to prolonged upregulation of hypothalamic GABA A receptors and increases behavioral sensitivity to gaboxadol. | Neuroscience letters 20080711 |
| One-pot synthesis of highly functionalized pyridines via a rhodium carbenoid induced ring expansion of isoxazoles. | Journal of the American Chemical Society 20080709 |
| Fungicidal effect and the mode of action of piscidin 2 derived from hybrid striped bass. | Biochemical and biophysical research communications 20080704 |
| Crystal structures of Escherichia coli gamma-glutamyltranspeptidase in complex with azaserine and acivicin: novel mechanistic implication for inhibition by glutamine antagonists. | Journal of molecular biology 20080704 |
| Gaboxadol -- a different hypnotic profile with no tolerance to sleep EEG and sedative effects after repeated daily dosing. | Pharmacology, biochemistry, and behavior 20080701 |
| The use of voltage-sensitive dyes to monitor signal-induced changes in membrane potential-ABA triggered membrane depolarization in guard cells. | The Plant journal : for cell and molecular biology 20080701 |
| Molecular analysis and anticonvulsant therapy in two patients with glucose transporter 1 deficiency syndrome: a successful use of zonisamide for controlling the seizures. | Epilepsy research 20080701 |
| Cell type-specific GABA A receptor-mediated tonic inhibition in mouse neocortex. | Journal of neurophysiology 20080701 |
| Exacerbation of Whipple disease by immunosuppressants. | Journal of clinical gastroenterology 20080701 |
| Effects of a non-selective COX inhibitor and selective COX-2 inhibitors on contractility of human and porcine ureters in vitro and in vivo. | British journal of pharmacology 20080701 |
| Isobaric metabolite interferences and the requirement for close examination of raw data in addition to stringent chromatographic separations in liquid chromatography/tandem mass spectrometric analysis of drugs in biological matrix. | Rapid communications in mass spectrometry : RCM 20080701 |
| Paliperidone extended-release tablets in schizophrenia patients previously treated with risperidone. | International clinical psychopharmacology 20080701 |
| Modeling spheroid growth, PET tracer uptake, and treatment effects of the Hsp90 inhibitor NVP-AUY922. | Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20080701 |
| Small-molecule activation of neuronal cell fate. | Nature chemical biology 20080701 |
| Validated LC-MS/MS methods for the determination of risperidone and the enantiomers of 9-hydroxyrisperidone in human plasma and urine. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080701 |
| Zonisamide concentrations during pregnancy. | The Annals of pharmacotherapy 20080701 |
| Induction treatment of proliferative lupus nephritis with leflunomide combined with prednisone: a prospective multi-centre observational study. | Lupus 20080701 |
| Comparison of parecoxib and proparacetamol in endoscopic nasal surgery patients. | Yonsei medical journal 20080630 |
| Macrophage migration inhibitory factor induces cardiomyocyte apoptosis. | Biochemical and biophysical research communications 20080627 |
| Synthesis and biological evaluation of D-amino acid oxidase inhibitors. | Journal of medicinal chemistry 20080626 |
| Synthesis and evaluation of estrogen agonism of diaryl 4,5-dihydroisoxazoles, 3-hydroxyketones, 3-methoxyketones, and 1,3-diketones: a compound set forming a 4D molecular library. | Journal of medicinal chemistry 20080626 |
| Lysophosphatidic acid protects cancer cells from histone deacetylase (HDAC) inhibitor-induced apoptosis through activation of HDAC. | The Journal of biological chemistry 20080613 |
| A systematic review and meta-analysis of efficacy and toxicity of disease modifying anti-rheumatic drugs and biological agents for psoriatic arthritis. | Annals of the rheumatic diseases 20080601 |
| Synthesis, potentiometric and antimicrobial studies on metal complexes of isoxazole Schiff bases. | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20080601 |
| Risk of ischaemic cardiovascular events from selective cyclooxygenase-2 inhibitors in osteoarthritis. | Pharmacoepidemiology and drug safety 20080601 |
| Zonisamide decreases cortical excitability in patients with idiopathic generalized epilepsy. | Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 20080601 |
| Does drug-induced hypersensitivity syndrome elicit bullous pemphigoid? | Allergology international : official journal of the Japanese Society of Allergology 20080601 |
| Hypoxia-inducible factor augments experimental colitis through an MIF-dependent inflammatory signaling cascade. | Gastroenterology 20080601 |
| Identification of non-lipid LPA3 antagonists by virtual screening. | Bioorganic & medicinal chemistry 20080601 |
| Pharmacokinetics of zonisamide and drug interaction with phenobarbital in dogs. | Journal of veterinary pharmacology and therapeutics 20080601 |
| Synthesis and anticonvulsant activity of aromatic tetramethylcyclopropanecarboxamide derivatives. | Bioorganic & medicinal chemistry 20080601 |
| Multimodal analgesia without parenteral narcotics for total knee arthroplasty. | The Journal of arthroplasty 20080601 |
| Secondary osteoporosis in long-term bedridden patients with cerebral palsy. | Pediatrics international : official journal of the Japan Pediatric Society 20080601 |
| Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity. | Expert opinion on emerging drugs 20080601 |
| Zonisamide suppresses pain symptoms of formalin-induced inflammatory and streptozotocin-induced diabetic neuropathy. | Journal of pharmacological sciences 20080601 |
| Hospitalization rates before and after initiation of paliperidone ER in patients with schizophrenia: results from open-label extensions of the US double-blind trials. | Current medical research and opinion 20080601 |
| The active metabolite of leflunomide A771726 inhibits corneal neovascularization. | Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20080601 |
| Conversion of oximes to carbonyl compounds by triscetylpyridinium tetrakis(oxodiperoxotungsto) phosphate (PCWP)-mediated oxidation with hydrogen peroxide. | Molecules (Basel, Switzerland) 20080601 |
| Impaired GABAergic transmission disrupts normal homeostatic plasticity in rat cortical networks. | The European journal of neuroscience 20080601 |
| Negative effect of parecoxib on bone mineral during fracture healing in rats. | Acta orthopaedica 20080601 |
| Sitaxentan: new drug. Pulmonary hypertension: better to continue to use bosentan. | Prescrire international 20080601 |
| 2,5-Dimethyl-3-(3-methyl-thio-phen-2-yl)perhydro-pyrrolo[3,4-d]isoxazole-4,6-dione. | Acta crystallographica. Section E, Structure reports online 20080601 |
| Peroxisome proliferator-activated receptor-gamma coactivator-1alpha activation of CYP7A1 during food restriction and diabetes is still inhibited by small heterodimer partner. | The Journal of biological chemistry 20080530 |
| Effect of microdialysis perfusion of 4,5,6,7-tetrahydroisoxazolo-[5,4-c]pyridine-3-ol in the perifornical hypothalamus on sleep-wakefulness: role of delta-subunit containing extrasynaptic GABAA receptors. | Neuroscience 20080515 |
| Theoretical study on the electronic states of formylcarbene (HC.CHO) and triplet ketene (H2CCO) and the ultraviolet absorption spectra attributable to these molecules. | The journal of physical chemistry. A 20080508 |
| Efficacy of the selective extrasynaptic GABA A agonist, gaboxadol, in a model of transient insomnia: a randomized, controlled clinical trial. | Sleep medicine 20080501 |
| Comparative study of the effect of luminal hypotonicity on mucosal permeability in rat upper gastrointestinal tract. | Acta physiologica (Oxford, England) 20080501 |
| Discriminative stimulus effects of tiagabine and related GABAergic drugs in rats. | Psychopharmacology 20080501 |
| Reduced spontaneous relaxation in immature guinea pig airway smooth muscle is associated with increased prostanoid release. | American journal of physiology. Lung cellular and molecular physiology 20080501 |
| Chemical and biological investigation of N-hydroxy-valdecoxib: An active metabolite of valdecoxib. | Bioorganic & medicinal chemistry 20080501 |
| Antiepileptic activity of zonisamide on hippocampal CA3 neurons does not depend on carbonic anhydrase inhibition. | Epilepsy research 20080501 |
| Higher levels of leflunomide are associated with hemolysis and are not superior to lower levels for BK virus clearance in renal transplant patients. | Clinical journal of the American Society of Nephrology : CJASN 20080501 |
| Paliperidone for treatment of schizophrenia. | Schizophrenia bulletin 20080501 |
| Efficient and divergent synthesis of fully substituted 1H-pyrazoles and isoxazoles from cyclopropyl oximes. | Organic letters 20080501 |
| Leflunomide therapy in kidney transplantation: ready for prime time? | Clinical journal of the American Society of Nephrology : CJASN 20080501 |
| Pd-catalyzed carboetherification of beta,gamma-unsaturated oximes: a novel approach to Delta2-isoxazolines. | Organic letters 20080501 |
| Leflunomide as a remission-maintaining therapy in difficult-to-treat dermatomyositis. | Annals of the rheumatic diseases 20080501 |
| Effect of paracetamol and coxib with or without dexamethasone after laparoscopic cholecystectomy. | Acta anaesthesiologica Scandinavica 20080501 |
| Clinical images: healing of sacroiliitis with leflunomide and sulfasalazine treatment. | Arthritis and rheumatism 20080501 |
| [A 47-year-old dog breeder with chronic polyarthritis, weight loss and high fever]. | Zeitschrift fur Gastroenterologie 20080501 |
| Efficacy and tolerability of oral paliperidone extended-release tablets in the treatment of acute schizophrenia: pooled data from three 6-week, placebo-controlled studies. | The Journal of clinical psychiatry 20080501 |
| [Study on protective effects and its mechanism of leflunomide on renal tissue in rat IgA nephropathy model]. | Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20080501 |
| Dioleoyl phosphatidic acid induces morphological changes through an endogenous LPA receptor in C6 glioma cells. | Archives of pharmacal research 20080501 |
| Slow wave sleep enhancement with gaboxadol reduces daytime sleepiness during sleep restriction. | Sleep 20080501 |
| Preserving confidentiality in the peer review process. | JAMA 20080423 |
| Synthesis of 1-substituted benzo[c]isoxazol-3(1H)-imines via tandem nitroso-ene/intramolecular cyclizations of 2-nitrosobenzonitrile. | The Journal of organic chemistry 20080418 |
| Paliperidone for schizophrenia. | The Cochrane database of systematic reviews 20080416 |
| NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis. | Cancer research 20080415 |
| 5-tert-butyl-N-pyrazol-4-yl-4,5,6,7-tetrahydrobenzo[d]isoxazole-3-carboxamide derivatives as novel potent inhibitors of Mycobacterium tuberculosis pantothenate synthetase: initiating a quest for new antitubercular drugs. | Journal of medicinal chemistry 20080410 |
| Synthesis and pharmacological characterization at glutamate receptors of the four enantiopure isomers of tricholomic acid. | Journal of medicinal chemistry 20080410 |
| Pharmacodynamic consequences of P-glycoprotein-dependent pharmacokinetics of risperidone and haloperidol in mice. | Behavioural brain research 20080409 |
| Bacteria induce CTGF and CYR61 expression in epithelial cells in a lysophosphatidic acid receptor-dependent manner. | International journal of medical microbiology : IJMM 20080401 |
| Treatment of Crohn's disease with leflunomide as second-line immunosuppression : a phase 1 open-label trial on efficacy, tolerability and safety. | Digestive diseases and sciences 20080401 |
| Clinical efficacy of zonisamide in Lennox-Gastaut syndrome: Korean multicentric experience. | Brain & development 20080401 |
| Enhanced behavioral sensitivity to the competitive GABA agonist, gaboxadol, in transgenic mice over-expressing hippocampal extrasynaptic alpha6beta GABA(A) receptors. | Journal of neurochemistry 20080401 |
| Gender-dependent ATPA-induced changes in long-term potentiation in the rat lateral amygdala. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080401 |
| Dose-finding study of paliperidone ER based on striatal and extrastriatal dopamine D2 receptor occupancy in patients with schizophrenia. | Psychopharmacology 20080401 |
| Double-blind, placebo-controlled, multiple-ascending-dose study on the effects of ABIO-08/01, a novel anxiolytic drug, on perception and cognition, utilizing event-related potential mapping and low-resolution brain electromagnetic tomography. | Human psychopharmacology 20080401 |
| Absorption, metabolism, and excretion of paliperidone, a new monoaminergic antagonist, in humans. | Drug metabolism and disposition: the biological fate of chemicals 20080401 |
| [Treatment of pulmonary arterial hypertension by endothelin receptor antagonists in 2008]. | La Revue de medecine interne 20080401 |
| Analgesia during extracorporeal shockwave lithotripsy: fentanyl citrate versus parecoxib sodium. | Journal of endourology 20080401 |
| A new isoxazol from Glehnia littoralis. | Fitoterapia 20080401 |
| On the role of tyrosine and peripheral metabolism in 3,4-methylenedioxymethamphetamine-induced serotonin neurotoxicity in rats. | Neuropharmacology 20080401 |
| New advances in the treatment of schizophrenia. Introduction. | Journal of clinical psychopharmacology 20080401 |
| Safety profile of iloperidone: a pooled analysis of 6-week acute-phase pivotal trials. | Journal of clinical psychopharmacology 20080401 |
| Four-week, double-blind, placebo- and ziprasidone-controlled trial of iloperidone in patients with acute exacerbations of schizophrenia. | Journal of clinical psychopharmacology 20080401 |
| Long-term efficacy and safety of iloperidone: results from 3 clinical trials for the treatment of schizophrenia. | Journal of clinical psychopharmacology 20080401 |
| Efficacy of iloperidone in the treatment of schizophrenia: initial phase 3 studies. | Journal of clinical psychopharmacology 20080401 |
| Suppressive effect of leflunomide on rat hepatic stellate cell proliferation involves on PDGF-BB-elicited activation of three mitogen-activated protein kinases. | Cytokine 20080401 |
| Carbonic anhydrase inhibition. Insight into the characteristics of zonisamide, topiramate, and the sulfamide cognate of topiramate. | Journal of enzyme inhibition and medicinal chemistry 20080401 |
| Structure-function studies on the active site of the coelenterazine-dependent luciferase from Renilla. | Protein science : a publication of the Protein Society 20080401 |
| A single-center experience with BK virus nephropathy. | Clinical nephrology 20080401 |
| Leflunomide-induced subacute cutaneous lupus erythematosus with erythema multiforme-like lesions. | Lupus 20080401 |
| Zonisamide: review of pharmacology, clinical efficacy, tolerability, and safety. | Expert opinion on drug metabolism & toxicology 20080401 |
| New drug update: 2007. | The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists 20080401 |
| Functional properties of alpha7 nicotinic acetylcholine receptors co-expressed with RIC-3 in a stable recombinant CHO-K1 cell line. | Assay and drug development technologies 20080401 |
| A high-capacity membrane potential FRET-based assay for the sodium-coupled glucose co-transporter SGLT1. | Assay and drug development technologies 20080401 |
| Prevention and inhibition but not reversion of chronic allograft vasculopathy by FK778. | Transplantation 20080327 |
| Burned rice straw reduces the availability of clomazone to barnyardgrass. | The Science of the total environment 20080325 |
| Activation of the farnesoid X receptor represses PCSK9 expression in human hepatocytes. | FEBS letters 20080319 |
| 3-amino-benzo[d]isoxazoles as novel multitargeted inhibitors of receptor tyrosine kinases. | Journal of medicinal chemistry 20080313 |
| Crunch time for peer review in lawsuit. | Nature 20080306 |
| Translocation-positive acute myeloid leukemia associated with valproic acid therapy. | Pediatric blood & cancer 20080301 |
| Cyclooxygenase-2 independent effects of cyclooxygenase-2 inhibitors on oxidative stress and intracellular glutathione content in normal and malignant human B-cells. | Cancer immunology, immunotherapy : CII 20080301 |
| Intravenous parecoxib rapidly leads to COX-2 inhibitory concentration of valdecoxib in the central nervous system. | Clinical pharmacology and therapeutics 20080301 |
| The immunomodulatory drug Leflunomide inhibits cell cycle progression of B-CLL cells. | Leukemia 20080301 |
| Lysophosphatidic acid-stimulated interleukin-6 and -8 synthesis through LPA1 receptors on human osteoblasts. | Archives of oral biology 20080301 |
| Synthesis of novel steroidal D-ring substituted isoxazoline derivatives of 17-oxoandrostanes. | Steroids 20080301 |
| Leflunomide as adjuvant treatment of dermatomyositis. | Journal of the American Academy of Dermatology 20080301 |
| Anti-tumor activity and tumor vessel normalization by the vascular endothelial growth factor receptor tyrosine kinase inhibitor KRN951 in a rat peritoneal disseminated tumor model. | Cancer science 20080301 |
| Anti-inflammatory and analgesic activities of newly synthesized chiral peptide derivatives using (3-benzoyl- 4,5-dioxo-2-phenyl-pyrrolidin-1-yl)acetic acid ethyl ester as starting material. | Archiv der Pharmazie 20080301 |
| Inhibition of the betaine-GABA transporter (mGAT2/BGT-1) modulates spontaneous electrographic bursting in the medial entorhinal cortex (mEC). | Epilepsy research 20080301 |
| Paliperidone: An improvement over risperidone? | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20080301 |
| Paliperidone for schizophrenia. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20080301 |
| Effect of a ciliary neurotrophic factor polymorphism on schizophrenia symptom improvement in an iloperidone clinical trial. | Pharmacogenomics 20080301 |
| Synthesis of progesterone heterocyclic derivatives of potential antimicrobial activity. | Acta pharmaceutica (Zagreb, Croatia) 20080301 |
| Zonisamide for the treatment of myoclonic seizures in progressive myoclonic epilepsy: an open-label study. | Epileptic disorders : international epilepsy journal with videotape 20080301 |
| [Leflunomide-induced skin necrosis]. | Annales de dermatologie et de venereologie 20080301 |
| Intrapulmonary rheumatoid nodules in a patient with long-standing rheumatoid arthritis treated with leflunomide. | Pathology oncology research : POR 20080301 |
| Lysophosphatidylserine induces calcium signaling through Ki16425/VPC32183-sensitive GPCR in bone marrow-derived mast cells and in C6 glioma and colon cancer cells. | Archives of pharmacal research 20080301 |
| Role of biotransformation studies in minimizing metabolism-related liabilities in drug discovery. | The AAPS journal 20080301 |
| Biotransformation of valdecoxib by plant cell cultures. | Applied biochemistry and biotechnology 20080301 |
| The expression of GABAA beta subunit isoforms in synaptic and extrasynaptic receptor populations of mouse dentate gyrus granule cells. | The Journal of physiology 20080215 |
| A synthetic derivative of plant allylpolyalkoxybenzenes induces selective loss of motile cilia in sea urchin embryos. | ACS chemical biology 20080215 |
| Discovery of benzisoxazoles as potent inhibitors of chaperone heat shock protein 90. | Journal of medicinal chemistry 20080214 |
| Highly enantioselective synthesis of isoxazoline N-oxides. | Chemical communications (Cambridge, England) 20080214 |
| Suppressive effects of leflunomide on leptin-induced TIMP-1 production involves on hepatic stellate cell proliferation and apoptosis. | European journal of pharmacology 20080202 |
| Lysophosphatidic acid regulates blood glucose by stimulating myotube and adipocyte glucose uptake. | Journal of molecular medicine (Berlin, Germany) 20080201 |
| Reductive isoxazole ring opening of the anticoagulant razaxaban is the major metabolic clearance pathway in rats and dogs. | Drug metabolism and disposition: the biological fate of chemicals 20080201 |
| FXR-mediated regulation of angiotensin type 2 receptor expression in vascular smooth muscle cells. | Cardiovascular research 20080201 |
| Relationship between prolactin secretion, and plasma risperidone and 9-hydroxyrisperidone concentrations in adolescents with schizophreniform disorder. | Psychoneuroendocrinology 20080201 |
| Preventive effects of perioperative parecoxib on post-discectomy pain. | British journal of anaesthesia 20080201 |
| 1H, 13C and 15N NMR studies on adducts formation of rhodium(II) tetraacylates with some azoles in CDCl3 solution. | Magnetic resonance in chemistry : MRC 20080201 |
| Pulmonary hypertension: basic concepts and practical management. | The European respiratory journal 20080201 |
| Endothelin receptor antagonists in pulmonary arterial hypertension. | The European respiratory journal 20080201 |
| Paliperidone-ER: first atypical antipsychotic with oral extended release formulation. | Expert review of neurotherapeutics 20080201 |
| Sleep-stabilizing effects of E-6199, compared to zopiclone, zolpidem and THIP in mice. | Sleep 20080201 |
| Toxic epidermal necrolysis due to zonisamide associated with reactivation of human herpesvirus 6. | Archives of dermatology 20080201 |
| [Zonisamide in refractory essential tremor]. | Revista de neurologia 20080201 |
| Advances in diagnosis and treatment in patients with pulmonary arterial hypertension. | Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20080201 |
| Paliperidone extended-release tablets for the acute and maintenance treatment of schizophrenia. | Clinical therapeutics 20080201 |
| Diffuse alveolar hemorrhage after leflunomide therapy in a patient with rheumatoid arthritis. | Journal of thoracic imaging 20080201 |
| [Psoriatic arthritis]. | Annales de dermatologie et de venereologie 20080201 |
| (E)-2-Meth-oxy-6-[(5-methyl-isoxazol-3-yl)imino-meth-yl]phenol. | Acta crystallographica. Section E, Structure reports online 20080201 |
| 4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer. | Journal of medicinal chemistry 20080124 |
| KRIBB3, a novel microtubule inhibitor, induces mitotic arrest and apoptosis in human cancer cells. | Biochemical pharmacology 20080115 |
| Antitumor effects of curcumin and structurally beta-diketone modified analogs on multidrug resistant cancer cells. | Bioorganic & medicinal chemistry letters 20080115 |
| Effect of parecoxib on postoperative pain after lumbar spine surgery: a bicenter, randomized, double-blinded, placebo-controlled trial. | Spine 20080115 |
| A new class of bradykinin B1 receptor antagonists with high oral bioavailability and minimal PXR activity. | Bioorganic & medicinal chemistry letters 20080115 |
| Identification, isolation and characterization of potential degradation product in risperidone tablets. | Journal of pharmaceutical and biomedical analysis 20080107 |
| Long-term use of zonisamide in refractory childhood-onset epilepsy. | European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 20080101 |
| Is adjunctive open-label zonisamide effective for bipolar disorder? | Journal of affective disorders 20080101 |
| Effects of zonisamide on experimental tremors in rats. | Parkinsonism & related disorders 20080101 |
| Leflunomide and methotrexate reduce levels of activated matrix metalloproteinases in complexes with alpha2 macroglobulin in serum of rheumatoid arthritis patients. | Annals of the rheumatic diseases 20080101 |
| Curcumin-derived pyrazoles and isoxazoles: Swiss army knives or blunt tools for Alzheimer's disease? | ChemMedChem 20080101 |
| Long-term cognitive and mood effects of zonisamide monotherapy in epilepsy patients. | Epilepsy & behavior : E&B 20080101 |
| Preventing effects of a novel anti-parkinsonian agent zonisamide on dopamine quinone formation. | Neuroscience research 20080101 |
| Effect of rifampin, an inducer of CYP3A and P-glycoprotein, on the pharmacokinetics of risperidone. | Journal of clinical pharmacology 20080101 |
| Iloperidone: a new benzisoxazole atypical antipsychotic drug. Is it novel enough to impact the crowded atypical antipsychotic market? | Expert opinion on investigational drugs 20080101 |
| Leflunomide-induced lung injury that developed after its withdrawal, coinciding with peripheral blood lymphocyte count decrease. | Modern rheumatology 20080101 |
| Safety and tolerability of oral paliperidone extended-release tablets in elderly patients with schizophrenia: a double-blind, placebo-controlled study with six-month open-label extension. | The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 20080101 |
| Cardiovascular effects of valdecoxib: transducing human pharmacology results into clinical read-outs. | Expert opinion on drug safety 20080101 |
| Leflunomide in subacute cutaneous lupus erythematosus - two sides of a coin. | International journal of dermatology 20080101 |
| Use of cox-2 inhibitors in patients with retinal venous occlusive disease. | Retina (Philadelphia, Pa.) 20080101 |
| Application of chiral cyclic nitrones to the diastereoselective synthesis of bicyclic isoxazolidine nucleoside analogues. | Nucleosides, nucleotides & nucleic acids 20080101 |
| Emerging concepts in the medical and surgical treatment of obesity. | Frontiers of hormone research 20080101 |
| Safety of parecoxib in patients with nonsteroidal anti-inflammatory drug-induced urticaria or angioedema. | Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20080101 |
| Severe cutaneous adverse drug reaction to leflunomide: a report of two cases. | Cutaneous and ocular toxicology 20080101 |
| Parecoxib as an alternative in COX-2 hypersensitivity. | International journal of immunopathology and pharmacology 20080101 |
| Xerosis and pityriasis alba-like changes associated with zonisamide. | Indian journal of dermatology, venereology and leprology 20080101 |
| Toluene-induced hearing loss in acivicin-treated rats. | Neurotoxicology and teratology 20080101 |
| NVP-AUY922: a small molecule HSP90 inhibitor with potent antitumor activity in preclinical breast cancer models. | Breast cancer research : BCR 20080101 |
| RM-11, an isoxazole derivative, accelerates restoration of the immune function in mice treated with cyclophosphamide. | Pharmacological reports : PR 20080101 |
| Early analgesic effects of intravenous parecoxib and rectal diclofenac following laparoscopic sterilization: a double-blind, double-dummy randomized controlled trial. | Journal of opioid management 20080101 |
| Synthesis of 5-(thiazol-5-yl)-4,5-dihydroisoxazoles from 3-chloropentane-2,4-dione. | Journal of combinatorial chemistry 20080101 |
| Endothelin receptor antagonists for pulmonary arterial hypertension: rationale and place in therapy. | American journal of cardiovascular drugs : drugs, devices, and other interventions 20080101 |
| Parecoxib versus dipyrone (metamizole) for postoperative pain relief after hysterectomy : a prospective, single-centre, randomized, double-blind trial. | Clinical drug investigation 20080101 |
| Proposals for leflunomide use to avoid lung injury in patients with rheumatoid arthritis. | Modern rheumatology 20080101 |
| Solid-phase synthesis of heterocyclic nucleoside analogues: substituted uracils tethered to isoxazoles, isoxazolines, and triazoles from a selenopolystyrene resin. | Journal of combinatorial chemistry 20080101 |
| Severe hypertriglygeridemia in a rheumatoid arthritis patient treated with leflunomide. | Clinical and experimental rheumatology 20080101 |
| A new class of isoxazole derivatives: the M 1-9 series of compounds with immunotropic activity. | Acta poloniae pharmaceutica 20080101 |
| Long-term therapeutic drug monitoring of risperidone and olanzapine identifies altered steady-state pharmacokinetics: a clinical, two-group, naturalistic study. | Clinical drug investigation 20080101 |
| Solution phase synthesis of a diverse library of highly substituted isoxazoles. | Journal of combinatorial chemistry 20080101 |
| [Leflunomide-induced toxic epidermal necrolysis]. | Therapie 20080101 |
| Endothelin receptor antagonism: role in the treatment of pulmonary arterial hypertension related to scleroderma. | Drugs 20080101 |
| Acivicin with glutaminase regulates proliferation and invasion of human MCF-7 and OAW-42 cells--an in vitro study. | Indian journal of experimental biology 20080101 |
| Formation of alpha-hydroxy-beta-diketones through hydroxylation of isoxazolium salts: stereoselective approach to angular cis-diols in polycyclic systems. | Angewandte Chemie (International ed. in English) 20080101 |
| Multiple-day efficacy of parecoxib sodium treatment in postoperative bunionectomy pain. | The Clinical journal of pain 20080101 |
| Endothelin receptor antagonists improve exercise tolerance and oxygen saturations in patients with Eisenmenger syndrome and congenital heart defects. | Texas Heart Institute journal 20080101 |
| [The efficacy and safety of the combination of leflunomide (Arava) and biological agents in treatment of rheumatoid arthritis]. | Reumatizam 20080101 |
| Combination treatment with infliximab and leflunomide in patients with active rheumatoid arthritis: safety and efficacy in an open-label clinical trial. | Clinical and experimental rheumatology 20080101 |
| Relapsing polychondritis: reversible airway obstruction or asthma. | Clinical and experimental rheumatology 20080101 |
| [Cardiovascular risk of cyclooxygenase selective inhibitors]. | Revista medica del Instituto Mexicano del Seguro Social 20080101 |
| FTIR studies on differential intermolecular association in crystalline and amorphous states of structurally related non-steroidal anti-inflammatory drugs. | Molecular pharmaceutics 20080101 |
| [Rezonizat and cycloserine in complex therapy of drug resistant tuberculosis (comparative studies)]. | Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20080101 |
| A high throughput serum paraoxonase assay for discovery of small molecule modulators of PON1 activity. | Current chemical genomics 20080101 |
| catena-Poly[bis-(sulfamethoxazolium) [[trichloridocadmate(II)]-μ-chlorido] monohydrate]. | Acta crystallographica. Section E, Structure reports online 20080101 |
| 5-Amino-3-(4-pyrid-yl)isoxazole. | Acta crystallographica. Section E, Structure reports online 20080101 |
| Efficacy and safety of paliperidone extended-release tablets: results of a 6-week, randomized, placebo-controlled study. | Biological psychiatry 20071215 |
| Dosage adjustments in hepatic dysfunction. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20071215 |
| Synthesis of natural product-inspired inhibitors of Mycobacterium tuberculosis mycothiol-associated enzymes: the first inhibitors of GlcNAc-Ins deacetylase. | Journal of medicinal chemistry 20071213 |
| The synthesis of highly substituted isoxazoles by electrophilic cyclization: an efficient synthesis of valdecoxib. | The Journal of organic chemistry 20071207 |
| The new malononitrilamide immunosuppressant FK778 prolongs corneal allograft survival in the rat keratoplasty model. | Eye (London, England) 20071201 |
| Towards a molecular genetic system for the pathogenic fungus Paracoccidioides brasiliensis. | Fungal genetics and biology : FG & B 20071201 |
| The pharmacokinetic profile of sitaxsentan, a selective endothelin receptor antagonist, in varying degrees of renal impairment. | British journal of clinical pharmacology 20071201 |
| FXR agonists and FGF15 reduce fecal bile acid excretion in a mouse model of bile acid malabsorption. | Journal of lipid research 20071201 |
| The effects of TBC3214, a selective endothelin ETA receptor antagonist, on orthodontic tooth movement in rats. | European journal of orthodontics 20071201 |
| Orthodontic tooth movement after different coxib therapies. | European journal of orthodontics 20071201 |
| [Anticonvulsant treatment with zonisamide added to topiramate. A preliminary treatment analysis in 19 patients]. | Der Nervenarzt 20071201 |
| In vitro resistance study of rupintrivir, a novel inhibitor of human rhinovirus 3C protease. | Antimicrobial agents and chemotherapy 20071201 |
| Discovery of novel isoxazolines as anti-tuberculosis agents. | Bioorganic & medicinal chemistry letters 20071201 |
| Point-of-care platelet function tests: detection of platelet inhibition induced by nonopioid analgesic drugs. | Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20071201 |
| A simple sample size formula for analysis of covariance in randomized clinical trials. | Journal of clinical epidemiology 20071201 |
| LPA1 receptor activation promotes renal interstitial fibrosis. | Journal of the American Society of Nephrology : JASN 20071201 |
| Farnesoid x receptor ligands inhibit vascular smooth muscle cell inflammation and migration. | Arteriosclerosis, thrombosis, and vascular biology 20071201 |
| The role of HLA-DRB1 shared epitope alleles in predicting short-term response to leflunomide in rheumatoid arthritis. | Rheumatology (Oxford, England) 20071201 |
| The new antiepileptic drugs. | Archives of disease in childhood. Education and practice edition 20071201 |
| Synthesis and bioassay of amino-pyrazolone, amino-isoxazolone and amino-pyrimidinone derivatives. | Chemical & pharmaceutical bulletin 20071201 |
| Paliperidone: new drug. Just a metabolite of risperidone, a neuroleptic soon off-patent. | Prescrire international 20071201 |
| Emerging treatment of atopic dermatitis. | Clinical reviews in allergy & immunology 20071201 |
| In vitro metabolism of leflunomide by mouse and human liver microsomes. | Drug metabolism letters 20071201 |
| Lysophosphatidylglycerol stimulates chemotactic migration and tube formation in human umbilical vein endothelial cells. | Biochemical and biophysical research communications 20071123 |
| The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor. | Biochemical and biophysical research communications 20071123 |
| Leflunomide inhibits PDK1/Akt pathway and induces apoptosis of human mast cells. | Journal of immunology (Baltimore, Md. : 1950) 20071115 |
| Spectroscopic, and thermal studies of some new binuclear transition metal(II) complexes with hydrazone ligands containing acetoacetanilide and isoxazole. | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20071101 |
| COX-2 inhibitors and postoperative ileus. | Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 20071101 |
| Short-term treatment with gaboxadol improves sleep maintenance and enhances slow wave sleep in adult patients with primary insomnia. | Psychopharmacology 20071101 |
| Leflunomide treatment for polyomavirus BK-associated nephropathy after kidney transplantation. | Transplant international : official journal of the European Society for Organ Transplantation 20071101 |
| GABAergic modulation of binge-like ethanol intake in C57BL/6J mice. | Pharmacology, biochemistry, and behavior 20071101 |
| Serum prolactin levels, plasma risperidone levels, polymorphism of cytochrome P450 2D6 and clinical response in patients with schizophrenia. | Journal of psychopharmacology (Oxford, England) 20071101 |
| Leflunomide-associated infections in rheumatoid arthritis. | The Journal of rheumatology 20071101 |
| Selective and mixed endothelin receptor antagonism in cardiovascular disease. | Trends in pharmacological sciences 20071101 |
| Successful treatment of cystoid macular edema with valdecoxib. | Journal of cataract and refractive surgery 20071101 |
| The pharmacology and safety of paliperidone extended-release in the treatment of schizophrenia. | Expert opinion on drug safety 20071101 |
| Protective effects of parecoxib, a cyclo-oxygenase-2 inhibitor, in postinfarction remodeling in the rat. | Journal of cardiovascular pharmacology 20071101 |
| Inhibition of cyclooxygenase-2 down-regulates osteoclast and osteoblast differentiation and favours adipocyte formation in vitro. | European journal of pharmacology 20071031 |
| Zonisamide in patients with essential tremor and Parkinson's disease. | Movement disorders : official journal of the Movement Disorder Society 20071031 |
| [Adverse effects of conventional DMARDs and biologic DMARDs]. | Nihon rinsho. Japanese journal of clinical medicine 20071028 |
| Processes affecting the dissipation of the herbicide isoxaflutole and its diketonitrile metabolite in agricultural soils under field conditions. | Journal of agricultural and food chemistry 20071017 |
| Neuronal nicotinic receptor agonists for the treatment of attention-deficit/hyperactivity disorder: focus on cognition. | Biochemical pharmacology 20071015 |
| Sensitive liquid chromatography/tandem mass spectrometry method for the simultaneous determination of olanzapine, risperidone, 9-hydroxyrisperidone, clozapine, haloperidol and ziprasidone in rat brain tissue. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071015 |
| Development and validation of a selective and sensitive bioanalytical procedure for the quantitative determination of gaboxadol in human plasma employing mixed mode solid phase extraction and hydrophilic interaction liquid chromatography with tandem mass spectroscopic detection. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071015 |
| Comparison of fate and transport of isoxaflutole to atrazine and metolachlor in 10 Iowa rivers. | Environmental science & technology 20071015 |
| Aza-Prins-pinacol approach to 7-azabicyclo[2.2.1]heptanes: syntheses of (+/-)-epibatidine and (+/-)-epiboxidine. | The Journal of organic chemistry 20071012 |
| Neurochemical regulation of sleep. | Journal of psychiatric research 20071001 |
| Limited efficacy of conventional DMARDs after initial methotrexate failure in patients with recent onset rheumatoid arthritis treated according to the disease activity score. | Annals of the rheumatic diseases 20071001 |
| Rituximab for treatment-resistant extensive Wegener's granulomatosis--additive effects of a maintenance treatment with leflunomide. | Clinical rheumatology 20071001 |
| Post-infection A77-1726 blocks pathophysiologic sequelae of respiratory syncytial virus infection. | American journal of respiratory cell and molecular biology 20071001 |
| Activatory properties of lysophosphatidic acid on human THP-1 cells. | Inflammation 20071001 |
| A mechanistic advance in understanding RSV pathogenesis, but still a long way from therapy. | American journal of respiratory cell and molecular biology 20071001 |
| Leflunomide prevents vasospasm secondary to subarachnoid haemorrhage. | Acta neurochirurgica 20071001 |
| Cutaneous infections with Stenotrophomonas maltophilia in patients using immunosuppressive medication. | Journal of the European Academy of Dermatology and Venereology : JEADV 20071001 |
| [Zonisamide and neuropathic pain]. | Revista de neurologia 20071001 |
| Neuroleptic malignant syndrome-like state in an epileptic patient with organic brain comorbidity treated with zonisamide and carbamazepine. | Epilepsia 20071001 |
| Paliperidone: a new extended-release oral atypical antipsychotic. | Expert opinion on pharmacotherapy 20071001 |
| Treatment, management, and monitoring of established rheumatoid arthritis. | The Journal of family practice 20071001 |
| Mechanism-of-action determination of GMP synthase inhibitors and target validation in Candida albicans and Aspergillus fumigatus. | Chemistry & biology 20071001 |
| Michael acceptors as cysteine protease inhibitors. | Mini reviews in medicinal chemistry 20071001 |
| Drug monitoring: simultaneous analysis of lamotrigine, oxcarbazepine, 10-hydroxycarbazepine, and zonisamide by HPLC-UV and a rapid GC method using a nitrogen-phosphorus detector for levetiracetam. | Journal of chromatographic science 20071001 |
| [New ways in the management of rheumatoid arthritis in Hungary]. | Lege artis medicinae : uj magyar orvosi hirmondo 20071001 |
| Postnatal development and kinetics of [3H]gaboxadol binding in rat brain: in vitro homogenate binding and quantitative autoradiography. | Brain research 20070919 |
| Robust isocratic high performance liquid chromatographic method for simultaneous determination of seven antiepileptic drugs including lamotrigine, oxcarbazepine and zonisamide in serum after solid-phase extraction. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070915 |
| Transferable potentials for phase equilibria. 9. Explicit hydrogen description of benzene and five-membered and six-membered heterocyclic aromatic compounds. | The journal of physical chemistry. B 20070913 |
| Analytical and semipreparative enantioseparation of 9-hydroxyrisperidone, the main metabolite of risperidone, using high-performance liquid chromatography and capillary electrophoresis. Validation and determination of enantiomeric purity. | Journal of chromatography. A 20070907 |
| The ubiquitin- and proteasome-dependent degradation of COX-2 is regulated by the COP9 signalosome and differentially influenced by coxibs. | Journal of molecular medicine (Berlin, Germany) 20070901 |
| Distinct electrophysiological effects of paliperidone and risperidone on the firing activity of rat serotonin and norepinephrine neurons. | Psychopharmacology 20070901 |
| Distinct profiles of alpha7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes. | Molecular pharmacology 20070901 |
| Postnatal adrenalectomy impairs urinary concentrating ability by increased COX-2 and leads to renal medullary injury. | American journal of physiology. Renal physiology 20070901 |
| Synthesis and binding affinity of new pyrazole and isoxazole derivatives as potential atypical antipsychotics. | Bioorganic & medicinal chemistry letters 20070901 |
| Maternal exposure to leflunomide associated with blindness and cerebral palsy. | Rheumatology (Oxford, England) 20070901 |
| Second look at leflunomide 'failure' to control cytomegalovirus infection in the setting of renal failure. | Transplant infectious disease : an official journal of the Transplantation Society 20070901 |
| Hypersensitivity pneumonitis associated with leflunomide therapy. | The Journal of rheumatology 20070901 |
| New antirheumatic drugs: any real added value? A critical overview of regulatory criteria for their marketing approval. | European journal of clinical pharmacology 20070901 |
| Insights in the regulation of cholesterol 7alpha-hydroxylase gene reveal a target for modulating bile acid synthesis. | Hepatology (Baltimore, Md.) 20070901 |
| The antitumor activities of curcumin and of its isoxazole analogue are not affected by multiple gene expression changes in an MDR model of the MCF-7 breast cancer cell line: analysis of the possible molecular basis. | International journal of molecular medicine 20070901 |
| A double-blind, placebo-controlled, randomized study evaluating the effect of paliperidone extended-release tablets on sleep architecture in patients with schizophrenia. | International clinical psychopharmacology 20070901 |
| Improving the analgesic efficacy of intrathecal morphine with parecoxib after total abdominal hysterectomy. | Anesthesia and analgesia 20070901 |
| In vitro effects of the active metabolite of leflunomide, A77 1726, on feline herpesvirus-1. | American journal of veterinary research 20070901 |
| [Do DMARDs contibute to impaired healing after surgery? Should they be discontinued before surgery?]. | Deutsche medizinische Wochenschrift (1946) 20070901 |
| Leflunomide in psoriatic arthritis. | Autoimmunity reviews 20070901 |
| Zonisamide for the treatment of Parkinson's disease. | Expert review of neurotherapeutics 20070901 |
| Parecoxib sodium administered over several days reduces pain after gynecologic surgery via laparotomy. | Journal of clinical anesthesia 20070901 |
| Partial agonism and antagonism of the ionotropic glutamate receptor iGLuR5: structures of the ligand-binding core in complex with domoic acid and 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid. | The Journal of biological chemistry 20070831 |
| Quantitative structure-activity relationship studies of [(biphenyloxy)propyl]isoxazole derivatives. Inhibitors of human rhinovirus 2 replication. | Journal of medicinal chemistry 20070823 |
| Functional characterization of Tet-AMPA [tetrazolyl-2-amino-3-(3-hydroxy-5-methyl- 4-isoxazolyl)propionic acid] analogues at ionotropic glutamate receptors GluR1-GluR4. The molecular basis for the functional selectivity profile of 2-Bn-Tet-AMPA. | Journal of medicinal chemistry 20070823 |
| Synthesis of resorcinol derived spironitronates. | Organic letters 20070816 |
| Validation and implementation of drug-dependent antibody assays in clinical trials for safety monitoring of patients dosed with roxifiban, an orally bioavailable glycoprotein IIb/IIIa antagonist. | Journal of pharmaceutical and biomedical analysis 20070815 |
| [Neuromuscular disorders caused by adverse effects of antiepileptics]. | Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20070810 |
| A case of Moebius syndrome presenting with congenital bilateral vocal cord paralysis. | European journal of pediatrics 20070801 |
| Safety and efficacy of leflunomide in primary Sjögren's syndrome: a phase II pilot study. | Annals of the rheumatic diseases 20070801 |
| Step-up combination versus switching of non-biological disease-modifying antirheumatic drugs in rheumatoid arthritis: results from a retrospective observational study. | Annals of the rheumatic diseases 20070801 |
| Cost analysis applied to postoperative analgesia regimens: a comparison between parecoxib and propacetamol. | Pharmacy world & science : PWS 20070801 |
| Razaxaban, a direct factor Xa inhibitor, in combination with aspirin and/or clopidogrel improves low-dose antithrombotic activity without enhancing bleeding liability in rabbits. | Journal of thrombosis and thrombolysis 20070801 |
| The methylerythritol phosphate pathway for isoprenoid biosynthesis in coccidia: presence and sensitivity to fosmidomycin. | Experimental parasitology 20070801 |
| Eight versus 16-week re-evaluation period in rheumatoid arthritis patients treated with leflunomide or methotrexate accompanied by moderate dose prednisone. | Rheumatology international 20070801 |
| Zonisamide and renal calculi in patients with epilepsy: how big an issue? | Current medical research and opinion 20070801 |
| Tocolytic effect of parecoxib, a new parenteral cyclo-oxygenase-2-specific inhibitor, on the spontaneous and prostaglandin-induced contractions of rat isolated myometrium. | Clinical and experimental pharmacology & physiology 20070801 |
| Enantioselective analysis of the antipsychotic 9-hydroxyrisperidone, main metabolite of risperidone, by chiral capillary EKC using dual CDs. | Electrophoresis 20070801 |
| Withdrawal of COX-2 selective inhibitors rofecoxib and valdecoxib: impact on NSAID and gastroprotective drug prescribing and utilization. | Current medical research and opinion 20070801 |
| Serotonin but not zonisamide inhibits theophylline-induced epileptiform activity in guinea pig hippocampal CA3 neurons. | Epilepsy research 20070801 |
| Early clinical experience with leflunomide in uveitis. | Canadian journal of ophthalmology. Journal canadien d'ophtalmologie 20070801 |
| The selective and non-selective cyclooxygenase inhibitors valdecoxib and piroxicam induce the same postoperative analgesia and control of trismus and swelling after lower third molar removal. | Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20070801 |
| The supraspinally mediated analgesic effects of zonisamide in mice after peripheral nerve injury are independent of the descending monoaminergic system. | Journal of pharmacological sciences 20070801 |
| Combination therapy of zonisamide and bupropion for weight reduction in obese women: a preliminary, randomized, open-label study. | The Journal of clinical psychiatry 20070801 |
| Effect of compound EXP-2528 on angiotensin II-induced E-selectin and VCAM-1 expression in rat brain microvascular endothelial cells in vitro. | Yao xue xue bao = Acta pharmaceutica Sinica 20070801 |
| Na+-pyrophosphatase: a novel primary sodium pump. | Biochemistry 20070731 |
| Restless legs syndrome induced by zonisamide. | Movement disorders : official journal of the Movement Disorder Society 20070730 |
| Dual GABAA receptor-mediated inhibition in rat presympathetic paraventricular nucleus neurons. | The Journal of physiology 20070715 |
| Influence of rainfall distribution on simulations of atrazine, metolachlor, and isoxaflutole/metabolite transport in subsurface drained fields. | Journal of agricultural and food chemistry 20070711 |
| gamma-Glutamyl transpeptidase GGT4 initiates vacuolar degradation of glutathione S-conjugates in Arabidopsis. | FEBS letters 20070710 |
| An efficient synthesis of nitroalkenes by alkene cross metathesis: facile access to small ring systems. | Organic letters 20070705 |
| Asymmetric hydroformylation of vinyl acetate: application in the synthesis of optically active isoxazolines and imidazoles. | Organic letters 20070705 |
| Ethanolamine and related amino alcohols increase basal and evoked release of [3H]-D-aspartic acid from synaptosomes by enhancing the filling of synaptic vesicles. | European journal of pharmacology 20070702 |
| Recent development of small molecular specific inhibitor of protein tyrosine phosphatase 1B. | Medicinal research reviews 20070701 |
| Asymmetric synthesis of chiral piperazinylpropylisoxazoline ligands for dopamine receptors. | European journal of medicinal chemistry 20070701 |
| Lack of generalisation between the GABAA receptor agonist, gaboxadol, and allosteric modulators of the benzodiazepine binding site in the rat drug discrimination procedure. | Psychopharmacology 20070701 |
| Leflunomide versus methotrexate in Wegener's granulomatosis. | Rheumatology (Oxford, England) 20070701 |
| Risk of myocardial infarction associated with selective COX-2 inhibitors: meta-analysis of randomised controlled trials. | Pharmacoepidemiology and drug safety 20070701 |
| Efficacy, safety and early response of paliperidone extended-release tablets (paliperidone ER): results of a 6-week, randomized, placebo-controlled study. | Schizophrenia research 20070701 |
| Synthesis and evaluation of isoxazole derivatives as lysophosphatidic acid (LPA) antagonists. | Bioorganic & medicinal chemistry letters 20070701 |
| Synthesis and SAR of selective benzothiophene, benzofuran, and indole-based peroxisome proliferator-activated receptor delta agonists. | Bioorganic & medicinal chemistry letters 20070701 |
| Elevated relapse rate under oral methotrexate versus leflunomide for maintenance of remission in Wegener's granulomatosis. | Rheumatology (Oxford, England) 20070701 |
| Utility and sensitivity of the sore throat pain model: results of a randomized controlled trial on the COX-2 selective inhibitor valdecoxib. | Journal of clinical pharmacology 20070701 |
| Leflunomide and methotrexate combination in refractory adult-onset Still's disease. | The Annals of pharmacotherapy 20070701 |
| Synthesis and evaluation of radioiodine-labelled CP-118,954 for the in-vivo imaging of acetylcholinesterase. | Nuclear medicine communications 20070701 |
| Molecularly imprinted polymers as antibody mimics in automated on-line fluorescent competitive assays. | Analytical chemistry 20070701 |
| Efficacy and safety of adjunctive zonisamide therapy for refractory partial seizures. | Epilepsy research 20070701 |
| Limitations in discerning the effects of risperidone and its 9-hydroxy metabolite on prolactin levels in a small study of patients with schizophrenia. | Human psychopharmacology 20070701 |
| [Effective combination therapy of TNF antagonists with DMARDs]. | Nihon rinsho. Japanese journal of clinical medicine 20070701 |
| [Economic evaluation of a new treatment for rheumatoid arthritis]. | Nihon rinsho. Japanese journal of clinical medicine 20070701 |
| [Clinical study on effect of total panax notoginseng saponins on immune related inner environment imbalance in rheumatoid arthritis patients]. | Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20070701 |
| Polyamines in inflammation and their modulation by conventional anti-inflammatory drugs. | Indian journal of experimental biology 20070701 |
| Plasma pharmacokinetic characteristics of risperidone and their relationship to saliva concentrations in children with psychiatric or neurodevelopmental disorders. | Clinical therapeutics 20070701 |
| Treatment with risperidone for 4 weeks increased plasma 3-methoxy-4-hydroxypnenylglycol (MHPG) levels, but did not alter plasma brain-derived neurotrophic factor (BDNF) levels in schizophrenic patients. | Progress in neuro-psychopharmacology & biological psychiatry 20070630 |
| Development of potent inhibitors of the coxsackievirus 3C protease. | Biochemical and biophysical research communications 20070622 |
| Bis- and trisuracil nucleosides with nucleobases anchored to 11-, 12-, and 16-membered macrocyclic scaffolds: synthesis and aggregation study. | The Journal of organic chemistry 20070622 |
| Molecular modeling study for the binding of zonisamide and topiramate to the human mitochondrial carbonic anhydrase isoform VA. | Bioorganic & medicinal chemistry 20070615 |
| The importance of genetic background on pain behaviours and pharmacological sensitivity in the rat spared serve injury model of peripheral neuropathic pain. | European journal of pharmacology 20070614 |
| Intra-articular injection of the cyclooxygenase-2 inhibitor parecoxib attenuates osteoarthritis progression in anterior cruciate ligament-transected knee in rats: role of excitatory amino acids. | Osteoarthritis and cartilage 20070601 |
| Determination of risperidone and enantiomers of 9-hydroxyrisperidone in plasma by LC-MS/MS. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070601 |
| Ethanol induced NF-{kappa}B activation protects against cell injury in cultured rat gastric mucosal epithelium. | American journal of physiology. Gastrointestinal and liver physiology 20070601 |
| Tricyclic isoxazolines: identification of R226161 as a potential new antidepressant that combines potent serotonin reuptake inhibition and alpha2-adrenoceptor antagonism. | Bioorganic & medicinal chemistry 20070601 |
| Renal tubular acidosis associated with leflunomide. | Rheumatology (Oxford, England) 20070601 |
| In vivo imaging of farnesoid X receptor activity reveals the ileum as the primary bile acid signaling tissue. | Molecular endocrinology (Baltimore, Md.) 20070601 |
| HTS, chemical hybridization, and drug design identify a chemically unique antituberculosis agent-coupling serendipity and rational approaches to drug discovery. | ChemMedChem 20070601 |
| Dioleoyl phosphatidic acid increases intracellular Ca2+ through endogenous LPA receptors in C6 glioma and L2071 fibroblasts. | Prostaglandins & other lipid mediators 20070601 |
| Adjunctive zonisamide for treatment refractory anxiety. | International journal of clinical practice 20070601 |
| Topical dosage form of valdecoxib: preparation and pharmacological evaluation. | Acta pharmaceutica (Zagreb, Croatia) 20070601 |
| The influence of timing of administration on the analgesic efficacy of parecoxib in orthopedic surgery. | Anesthesia and analgesia 20070601 |
| Therapy with immunosuppressive drugs and biological agents and use of contraception in patients with rheumatic disease. | The Journal of rheumatology 20070601 |
| Compared benefit of approved and experimental immunosuppressive therapeutic approaches in multiple sclerosis. | Expert opinion on pharmacotherapy 20070601 |
| Cyclooxygenase inhibition attenuates 3-nitropropionic acid-induced neurotoxicity in rats: possible antioxidant mechanisms. | Fundamental & clinical pharmacology 20070601 |
| Protein binding of flucloxacillin in neonates. | Therapeutic drug monitoring 20070601 |
| Risk of interstitial lung disease associated with leflunomide treatment in Korean patients with rheumatoid arthritis. | Arthritis and rheumatism 20070601 |
| Preliminary development of a responder index for chronic low back pain. | The Journal of rheumatology 20070601 |
| Multimodal analgesia for radical prostatectomy provides better analgesia and shortens hospital stay. | Journal of clinical anesthesia 20070601 |
| Cutaneous adverse reactions to valdecoxib distinct from Stevens-Johnson syndrome and toxic epidermal necrolysis. | Archives of dermatology 20070601 |
| Improvement of cardiac function with parecoxib, a cyclo-oxygenase-2 inhibitor, in a rat model of ischemic heart failure. | Journal of cardiovascular pharmacology 20070601 |
| Zonisamide: new drug. No advantage in refractory partial epilepsy. | Prescrire international 20070601 |
| [Effects of leflunomide combined with hormone therapy for refractory IgA nephropathy]. | Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20070601 |
| Heteroaryl-substituted phenols as potential antioxidants. | The Journal of pharmacy and pharmacology 20070601 |
| Efficacy and tolerability of valdecoxib in treating the signs and symptoms of severe rheumatoid arthritis: a 12-week, multicenter, randomized, double-blind, placebo-controlled study. | Clinical therapeutics 20070601 |
| [Development and identifiability analysis of parent-metabolite pharmacokinetic model for risperidone and its main active metabolite 9-hydroxyrisperidone]. | Yao xue xue bao = Acta pharmaceutica Sinica 20070601 |
| [Leflunomide as a second choice treatment in patients with rheumatoid arthritis]. | Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20070601 |
| Molecule of the month. Paliperidone. | Drug news & perspectives 20070601 |
| Synthesis and in vitro antiprotozoal activities of dicationic 3,5-diphenylisoxazoles. | Journal of medicinal chemistry 20070517 |
| Improved HPLC-MS/MS method for determination of isoxaflutole (balance) and its metabolites in soils and forage plants. | Journal of agricultural and food chemistry 20070516 |
| The role of cycloxygenase-2 in the rodent kidney following ischaemia/reperfusion injury in vivo. | European journal of pharmacology 20070507 |
| Plasma and CNS concentrations of Gaboxadol in rats following subcutaneous administration. | European journal of pharmacology 20070507 |
| Analgesic efficacy of single-dose parecoxib for corneal suturing in children. | European journal of anaesthesiology 20070501 |
| COX-2 activity transiently contributes to increased water and NaCl excretion in the polyuric phase after release of ureteral obstruction. | American journal of physiology. Renal physiology 20070501 |
| Preliminary evaluation in rheumatoid arthritis activity in patients treated with TNF-alpha blocker plus methotrexate versus methotrexate or leflunomide alone. | Rheumatology international 20070501 |
| Effect of clomazone herbicide on biochemical and histological aspects of silver catfish (Rhamdia quelen) and recovery pattern. | Chemosphere 20070501 |
| Reduction of site-specific CYP3A-mediated metabolism for dual angiotensin and endothelin receptor antagonists in various in vitro systems and in cynomolgus monkeys. | Drug metabolism and disposition: the biological fate of chemicals 20070501 |
| Sclerodermoid graft-versus-host disease-like lesions occurring after drug-induced hypersensitivity syndrome. | The British journal of dermatology 20070501 |
| Effects of the kainate receptor agonist ATPA on glutamatergic synaptic transmission and plasticity during early postnatal development. | Neuropharmacology 20070501 |
| Constitutive cyclooxygenase-2 is involved in central nociceptive processes in humans. | Anesthesiology 20070501 |
| Zonisamide decreases ethanol intake in rats and mice. | Pharmacology, biochemistry, and behavior 20070501 |
| Novel oral agents for multiple sclerosis. | Current neurology and neuroscience reports 20070501 |
| LPA2 (EDG4) mediates Rho-dependent chemotaxis with lower efficacy than LPA1 (EDG2) in breast carcinoma cells. | American journal of physiology. Cell physiology 20070501 |
| Paliperidone extended-release tablets: a new atypical antipsychotic. | Journal of psychosocial nursing and mental health services 20070501 |
| A study of genetic (CYP2D6 and ABCB1) and environmental (drug inhibitors and inducers) variables that may influence plasma risperidone levels. | Pharmacopsychiatry 20070501 |
| Lack of bioequivalence between generic risperidone oral solution and originator risperidone tablets. | International journal of clinical pharmacology and therapeutics 20070501 |
| The selective extrasynaptic GABAA agonist, gaboxadol, improves traditional hypnotic efficacy measures and enhances slow wave activity in a model of transient insomnia. | Sleep 20070501 |
| Current treatment of West syndrome in Japan. | Journal of child neurology 20070501 |
| Transglutaminase 2 inhibitor, KCC009, disrupts fibronectin assembly in the extracellular matrix and sensitizes orthotopic glioblastomas to chemotherapy. | Oncogene 20070419 |
| 4-aryl-5-(4-piperidyl)-3-isoxazolol GABAA antagonists: synthesis, pharmacology, and structure-activity relationships. | Journal of medicinal chemistry 20070419 |
| Surface chemistry of five-membered aromatic ring molecules containing two different heteroatoms on Si(111)-7 x 7. | Journal of the American Chemical Society 20070418 |
| The COX-2 inhibitor parecoxib produces neuroprotective effects in MPTP-lesioned rats. | European journal of pharmacology 20070410 |
| KCC2-deficient mice show reduced sensitivity to diazepam, but normal alcohol-induced motor impairment, gaboxadol-induced sedation, and neurosteroid-induced hypnosis. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070401 |
| Risperidone and paliperidone inhibit p-glycoprotein activity in vitro. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070401 |
| Platelet GPIIb/IIIa antagonist, XV459, in heparin-induced thrombocytopenia. | American journal of hematology 20070401 |
| Durability of treatment with methotrexate in Venezuelan patients with rheumatoid arthritis. | Rheumatology international 20070401 |
| Population pharmacokinetics of risperidone and 9-hydroxyrisperidone in patients with acute episodes associated with bipolar I disorder. | Journal of pharmacokinetics and pharmacodynamics 20070401 |
| Activation by zonisamide, a newer antiepileptic drug, of large-conductance calcium-activated potassium channel in differentiated hippocampal neuron-derived H19-7 cells. | The Journal of pharmacology and experimental therapeutics 20070401 |
| Design, synthesis, and evaluation of non-steroidal farnesoid X receptor (FXR) antagonist. | Bioorganic & medicinal chemistry 20070401 |
| Novel chiral isoxazole derivatives: synthesis and pharmacological characterization at human beta-adrenergic receptor subtypes. | Bioorganic & medicinal chemistry 20070401 |
| Paliperidone: quo vadis? | International journal of clinical practice 20070401 |
| Modulation of mucosal permeability by vasoactive intestinal peptide or lidocaine affects the adjustment of luminal hypotonicity in rat duodenum. | Acta physiologica (Oxford, England) 20070401 |
| Successful treatment of cystoid macular edema with valdecoxib. | Journal of cataract and refractive surgery 20070401 |
| Psychosis following initiation of zonisamide. | The American journal of psychiatry 20070401 |
| [Inhibition of radiographic progression in rheumatoid arthritis by anti-rheumatic drugs (DMARDs)]. | Clinical calcium 20070401 |
| Zonisamide as treatment for seizures. | The Nurse practitioner 20070401 |
| Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues. | Molecular cancer therapeutics 20070401 |
| Extended-release paliperidone: efficacy, safety and tolerability profile of a new atypical antipsychotic. | Drugs of today (Barcelona, Spain : 1998) 20070401 |
| Potential efficacy of zonisamide in refractory juvenile myoclonic epilepsy: retrospective evidence from an Irish compassionate-use case series. | Irish medical journal 20070401 |
| The effect of FK778 on the progression of chronic allograft nephropathy in a rat model. | Transplantation 20070327 |
| From five- to six-membered rings: 3,4-diarylquinolinone as lead for novel p38MAP kinase inhibitors. | Journal of medicinal chemistry 20070322 |
| The synthesis and structure-activity relationship studies of selective acetyl-CoA carboxylase inhibitors containing 4-(thiazol-5-yl)but-3-yn-2-amino motif: polar region modifications. | Bioorganic & medicinal chemistry letters 20070315 |
| Experiences with an identification and quantification program for inhibitor-positive milk samples. | Analytica chimica acta 20070314 |
| Paliperidone (Invega) for schizophrenia. | The Medical letter on drugs and therapeutics 20070312 |
| Reaction pathways of the diketonitrile degradate of isoxaflutole with hypochlorite in water. | Journal of agricultural and food chemistry 20070307 |
| Interactions between zonisamide and conventional antiepileptic drugs in the mouse maximal electroshock test model. | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20070301 |
| Autoantibodies, metalloproteinases and bone markers in rheumatoid arthritis patients are unable to predict their responses to infliximab. | Rheumatology (Oxford, England) 20070301 |
| Effect of the immunomodulator leflunomide on the induction of endometriosis in an experimental rat model. | Fertility and sterility 20070301 |
| Cavitating pneumonia, a severe complication of leflunomide therapy in chronic polyarthritis. | Rheumatology (Oxford, England) 20070301 |
| A potent immunomodulatory compound, (S,R)-3-Phenyl-4,5-dihydro-5-isoxazole acetic acid, prevents spontaneous and accelerated forms of autoimmune diabetes in NOD mice and inhibits the immunoinflammatory diabetes induced by multiple low doses of streptozotocin in CBA/H mice. | The Journal of pharmacology and experimental therapeutics 20070301 |
| AlphaIIbbeta3 priming and clustering by orally active and intravenous integrin antagonists. | Journal of thrombosis and haemostasis : JTH 20070301 |
| Gaboxadol, a selective extrasynaptic GABA(A) agonist, does not generalise to other sleep-enhancing drugs: a rat drug discrimination study. | Neuropharmacology 20070301 |
| Modulation of extrasynaptic THIP conductances by GABAA-receptor modulators in mouse neocortex. | Journal of neurophysiology 20070301 |
| Simultaneous determination of lamotrigine, zonisamide, and carbamazepine in human plasma by high-performance liquid chromatography. | Biomedical chromatography : BMC 20070301 |
| Monitoring of the proton electrochemical gradient in reconstituted vesicles: quantitative measurements of both transmembrane potential and intravesicular pH by ratiometric fluorescent probes. | Journal of fluorescence 20070301 |
| Cyclooxygenase-2 inhibition increases gastric tone and delays gastric emptying in rats. | Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20070301 |
| Parecoxib - getting to the heart of the matter. | Anaesthesia 20070301 |
| Leflunomide failure to control recurrent cytomegalovirus infection in the setting of renal failure after allogeneic stem cell transplantation. | Transplant infectious disease : an official journal of the Transplantation Society 20070301 |
| Sitaxsentan for the prevention of experimental shunt-induced pulmonary hypertension. | Pediatric research 20070301 |
| Pharmacokinetics and drug interactions with zonisamide. | Epilepsia 20070301 |
| Suppressive effects of leflunomide on leptin-induced collagen I production involved in hepatic stellate cell proliferation. | Experimental biology and medicine (Maywood, N.J.) 20070301 |
| Endothelin receptor antagonists in the treatment of pulmonary arterial hypertension. | Clinics in chest medicine 20070301 |
| Prospective study of zonisamide therapy for refractory idiopathic epilepsy in dogs. | The Journal of small animal practice 20070301 |
| Is the malononitrilamide FK778 better for the prevention of acute or chronic rejection? | Transplantation proceedings 20070301 |
| [Pulmonary hypertension treatment: future prospects]. | Archivos de bronconeumologia 20070301 |
| The EEG effects of THIP (Gaboxadol) on sleep and waking are mediated by the GABA(A)delta-subunit-containing receptors. | The European journal of neuroscience 20070301 |
| Effect of short-term treatment with gaboxadol on sleep maintenance and initiation in patients with primary insomnia. | Sleep 20070301 |
| Effects of parecoxib and dipyrone on platelet aggregation in patients undergoing meniscectomy: a double-blind, randomized, parallel-group study. | Clinical therapeutics 20070301 |
| Are new agents used to treat rheumatoid arthritis safe to take during pregnancy? Organization of Teratology Information Specialists (OTIS) study. | Canadian family physician Medecin de famille canadien 20070301 |
| Synthesis and cytotoxic activities of 4,5-diarylisoxazoles. | Bioorganic & medicinal chemistry letters 20070215 |
| Sitaxsentan in the management of pulmonary arterial hypertension. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20070215 |
| VP4 protein from human rhinovirus 14 is released by pressure and locked in the capsid by the antiviral compound WIN. | Journal of molecular biology 20070209 |
| Parecoxib vs. lornoxicam in the treatment of postoperative pain after laparoscopic cholecystectomy: a prospective randomized placebo-controlled trial. | European journal of anaesthesiology 20070201 |
| A single point mutation of the GABA(A) receptor alpha5-subunit confers fluoxetine sensitivity. | Neuropharmacology 20070201 |
| Synthesis and biological evaluation of 4-methylideneisoxazolidin-5-ones--a new class of highly cytotoxic alpha-methylidene-gamma-lactones. | European journal of medicinal chemistry 20070201 |
| Auto-modulation of neuroactive steroids on GABA A receptors: a novel pharmacological effect. | Neuropharmacology 20070201 |
| Treatment of schizophrenia with paliperidone extended-release tablets: a 6-week placebo-controlled trial. | Schizophrenia research 20070201 |
| Leflunomide-induced peripheral neuropathy. | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20070201 |
| Pulmonary adverse events with leflunomide--myth or reality? | Rheumatology (Oxford, England) 20070201 |
| Paliperidone extended-release tablets for prevention of symptom recurrence in patients with schizophrenia: a randomized, double-blind, placebo-controlled study. | Journal of clinical psychopharmacology 20070201 |
| Prolactin release in children treated with risperidone: impact and role of CYP2D6 metabolism. | Journal of clinical psychopharmacology 20070201 |
| The effect of modulation of gamma-glutamyl transpeptidase and nitric oxide synthase activity on GSH homeostasis in HepG2 cells. | Fundamental & clinical pharmacology 20070201 |
| Effect of leflunomide on the peripheral nerves in rheumatoid arthritis. | Internal medicine journal 20070201 |
| Dual mycobacterial infection in the setting of leflunomide treatment for rheumatoid arthritis. | Annals of the rheumatic diseases 20070201 |
| FDA approves new antipsychotic. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20070201 |
| Effects of oral pregabalin and aprepitant on pain and central sensitization in the electrical hyperalgesia model in human volunteers. | British journal of anaesthesia 20070201 |
| Function of phytochelatin synthase in catabolism of glutathione-conjugates. | The Plant journal : for cell and molecular biology 20070201 |
| [Development of novel nuclear receptor ligands based on receptor-folding inhibition hypothesis]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20070201 |
| Population estimation of the effects of cytochrome P450 2C9 and 2C19 polymorphisms on phenobarbital clearance in Japanese. | Therapeutic drug monitoring 20070201 |
| [Newer antiepileptic drugs]. | No to shinkei = Brain and nerve 20070201 |
| Mitochondrial protection by the JNK inhibitor leflunomide rescues mice from acetaminophen-induced liver injury. | Hepatology (Baltimore, Md.) 20070201 |
| Disease-modifying antirheumatic drug use in the elderly rheumatoid arthritis patient. | Rheumatic diseases clinics of North America 20070201 |
| Lung-derived macrophage migration inhibitory factor in sepsis induces cardio-circulatory depression. | Surgical infections 20070201 |
| Rapidly disintegrating risperidone in subjects with schizophrenia or schizoaffective disorder: a summary of ten phase I clinical trials assessing taste, tablet disintegration time, bioequivalence, and tolerability. | Clinical therapeutics 20070201 |
| A review of sitaxsentan sodium in patients with pulmonary arterial hypertension. | Vascular health and risk management 20070201 |
| Optimization of monocarboxylate transporter 1 blockers through analysis and modulation of atropisomer interconversion properties. | Journal of medicinal chemistry 20070125 |
| Cyclooxygenase inhibition and adverse remodeling during healing after myocardial infarction. | Circulation 20070123 |
| The progesterone metabolite allopregnanolone potentiates GABA(A) receptor-mediated inhibition of 5-HT neuronal activity. | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20070115 |
| A double-blind placebo-controlled trial of zonisamide (zonegran) in the treatment of essential tremor. | Movement disorders : official journal of the Movement Disorder Society 20070115 |
| Zonisamide improves motor function in Parkinson disease: a randomized, double-blind study. | Neurology 20070102 |
| The incidence of pancytopenia in patients taking leflunomide alone or with methotrexate. | Pharmacoepidemiology and drug safety 20070101 |
| Peripheral neuropathy associated with leflunomide: is there a risk patient profile? | Pharmacoepidemiology and drug safety 20070101 |
| The immunosuppressive drug FK778 induces regulatory activity in stimulated human CD4+ CD25- T cells. | Blood 20070101 |
| Inhibition of restenosis development after mechanical injury: a new field of application for malononitrilamides? | Cardiology 20070101 |
| Novel anticonvulsant drugs. | Pharmacology & therapeutics 20070101 |
| Impairment of T cell interactions with antigen-presenting cells by immunosuppressive drugs reveals involvement of calcineurin and NF-kappaB in immunological synapse formation. | Journal of leukocyte biology 20070101 |
| Lysophosphatidic acid stimulates neuronal differentiation of cortical neuroblasts through the LPA1-G(i/o) pathway. | Neurochemistry international 20070101 |
| Leflunomide as an antiatherogenic drug. | Medical hypotheses 20070101 |
| Zonisamide or levetiracetam for adults with cyclic vomiting syndrome: a case series. | Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20070101 |
| Sitaxsentan: a selective endothelin-A receptor antagonist, for the treatment of pulmonary arterial hypertension. | Expert opinion on pharmacotherapy 20070101 |
| Zonisamide for bipolar depression. | Expert opinion on pharmacotherapy 20070101 |
| Sitaxsentan for treatment of pulmonary hypertension. | The Annals of pharmacotherapy 20070101 |
| Prospective randomized, double-blind, placebo-controlled study of pre- and postoperative administration of a COX-2-specific inhibitor as opioid-sparing analgesia in major colorectal surgery. | Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 20070101 |
| Cutaneous sarcoidosis therapy updated. | Journal of the American Academy of Dermatology 20070101 |
| Clinical practice format for choosing a second-line disease modifying anti-rheumatic drug in early rheumatoid arthritis after failure of 6 months' first-line DMARD therapy. | Joint, bone, spine : revue du rhumatisme 20070101 |
| Safety of parecoxib and valdecoxib after noncardiac surgery: lack of demonstration. | Anesthesiology 20070101 |
| Reiter syndrome triggered by adalimumab (Humira) and leflunomide (Arava) in a patient with ankylosing spondylarthropathy and Crohn disease. | The British journal of dermatology 20070101 |
| Selective and nonselective cyclooxygenase-2 inhibitors and experimental fracture-healing. Reversibility of effects after short-term treatment. | The Journal of bone and joint surgery. American volume 20070101 |
| Solid-phase synthesis of linked heterocycles from a selenopolystyrene resin. | Journal of combinatorial chemistry 20070101 |
| Selective nucleophilic chemistry in the synthesis of 5-carbamoyl-3-sulfanylmethylisoxazole-4-carboxylic acids. | Journal of combinatorial chemistry 20070101 |
| [Valproate sodium and zonisamide associated interstitial pneumonitis in an infant]. | No to hattatsu = Brain and development 20070101 |
| Sitaxsentan treatment for patients with pulmonary arterial hypertension discontinuing bosentan. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20070101 |
| FK778 in experimental xenotransplantation: a detailed analysis of drug efficacy. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20070101 |
| Erratum to 'Safety of zonisamide therapy: prospective follow-up survey.'. | Seizure 20070101 |
| COX-2 inhibitors celecoxib and parecoxib: valuable options for postoperative pain management. | Current topics in medicinal chemistry 20070101 |
| Valdecoxib is as efficacious as diclofenac in the treatment of acute low back pain. | The Clinical journal of pain 20070101 |
| Valproic acid improves psychotic agitation without influencing plasma risperidone levels in schizophrenic patients. | Pharmacopsychiatry 20070101 |
| Study of the effects on DNA of two novel nucleoside derivatives synthesized as potential anti-HIV agents. | Drug and chemical toxicology 20070101 |
| Sitaxentan: in pulmonary arterial hypertension. | Drugs 20070101 |
| [Study on spectroscopy of 3-substituted phenyl-5-(3'-indolyl)-isoxazoline derivatives]. | Guang pu xue yu guang pu fen xi = Guang pu 20070101 |
| Effectiveness and safety of leflunomide in the clinical practice. A different experience. | Clinical and experimental rheumatology 20070101 |
| [Anakinra, a recombinant human IL-1 receptor antagonist, in clinical practice. Outcome in 60 patients with severe rheumatoid arthritis]. | Reumatismo 20070101 |
| Paliperidone extended release. | CNS drugs 20070101 |
| Rheumatoid arthritis patients with therapy-induced myelodysplastic syndrome present with long-term remission after recovery. | Scandinavian journal of rheumatology 20070101 |
| Antiobesity carbonic anhydrase inhibitors. | Current topics in medicinal chemistry 20070101 |
| New drugs: paliperidone, dasatinib, and decitabine. | Journal of the American Pharmacists Association : JAPhA 20070101 |
| Pharmacology of epidermal growth factor inhibitors. | The International journal of biological markers 20070101 |
| [Cost of rheumatoid arthritis in france: comparison leflunomide/etanercept]. | Therapie 20070101 |
| New drug for schizophrenia. | FDA consumer 20070101 |
| Teratogenicity study of the dihydroorotate-dehydrogenase inhibitor and protein tyrosine kinase inhibitor Leflunomide in mice. | Reproductive toxicology (Elmsford, N.Y.) 20070101 |
| COX-2 inhibitors and cardiovascular risk. | Sub-cellular biochemistry 20070101 |
| Postoperative administration of the analgesic tramadol, but not the selective cyclooxygenase-2 inhibitor parecoxib, abolishes postoperative hyperalgesia in a new model of postoperative pain in rats. | Pharmacology 20070101 |
| [Severe vitamin K deficiency during a drug wash-out procedure with cholestyramine]. | Gastroenterologie clinique et biologique 20070101 |
| Acute hepatitis associated to leflunomide in a patient with rheumatoid arthritis. | Gastroenterologia y hepatologia 20070101 |
| Prolonged survival with FK778 (malononitrilamide) monotherapy after small bowel transplantation: a large animal study. | Transplantation proceedings 20070101 |
| Preparation and properties of valdecoxib-hydroxypropyl beta-cyclodextrin inclusion complex. | PDA journal of pharmaceutical science and technology 20070101 |
| Clinical pharmacology and mechanism of action of zonisamide. | Clinical neuropharmacology 20070101 |
| Staphylococcus aureus thymic abscesses associated with anti-tumour necrosis factor therapy. | Scandinavian journal of rheumatology 20070101 |
| Conventional therapy of psoriatic arthritis: evidence-based review. | Reumatismo 20070101 |
| Molecular and thermodynamic aspects of solubility advantage from solid dispersions. | Molecular pharmaceutics 20070101 |
| An effective dose of valdecoxib in experimental mouse models of pain. | Methods and findings in experimental and clinical pharmacology 20070101 |
| [Results of leflunomide treatment of psoriatic arthritis]. | Terapevticheskii arkhiv 20070101 |
| Pancytopenia, including macrocytic anemia, associated with leflunomide in a rheumatoid arthritis patient. | Modern rheumatology 20070101 |
| The therapy of Sjogren's syndrome: a review. | La Clinica terapeutica 20070101 |
| Possible neuroleptic malignant syndrome associated with paliperidone. | The Journal of neuropsychiatry and clinical neurosciences 20070101 |
| Forty years of antipsychotic Drug research--from haloperidol to paliperidone--with Dr. Paul Janssen. | Arzneimittel-Forschung 20070101 |
| Zonisamide for essential tremor. | Clinical neuropharmacology 20070101 |
| Leflunomide in psoriatic arthritis: a retrospective study of discontinuation rate in daily clinical practice compared with methotrexate. | Clinical and experimental rheumatology 20070101 |
| Leflunomide and acute hypocalcemia. | Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20070101 |
| Protective effect of non-selective and selective COX-2-inhibitors in acute immobilization stress-induced behavioral and biochemical alterations. | Pharmacological reports : PR 20070101 |
| [Pulmonary hypertension and right ventricular failure. Part XI. Endothelin receptor blockers in the treatment of primary pulmonary arterial hypertension]. | Kardiologiia 20070101 |
| [Leflunomide (Arava) in the treatment of rheumatoid arthritis]. | Reumatizam 20070101 |
| [Security of the combined treatment of methotrexate and leflunomide in patients with rheumatoid arthritis]. | Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina) 20070101 |
| Farnesoid X receptor agonist reduces serum asymmetric dimethylarginine levels through hepatic dimethylarginine dimethylaminohydrolase-1 gene regulation. | The Journal of biological chemistry 20061229 |
| Inhibition of macrophage migration inhibitory factor or its receptor (CD74) attenuates growth and invasion of DU-145 prostate cancer cells. | Journal of immunology (Baltimore, Md. : 1950) 20061215 |
| Structure-activity relationship analysis of the selective inhibition of transglutaminase 2 by dihydroisoxazoles. | Journal of medicinal chemistry 20061214 |
| [Treatment of pulmonary arterial hypertension: endothelin-receptor antagonists]. | Deutsche medizinische Wochenschrift (1946) 20061208 |
| Differential effects of cyclooxygenase inhibitors on intracerebroventricular colchicine-induced dysfunction and oxidative stress in rats. | European journal of pharmacology 20061203 |
| Leflunomide combined with conventional disease-modifying antirheumatic drugs or biologics in patients with rheumatoid arthritis. | Joint, bone, spine : revue du rhumatisme 20061201 |
| Update on the medical treatment of juvenile idiopathic arthritis. | Current rheumatology reports 20061201 |
| Prolactin elevation of the antipsychotic risperidone is predominantly related to its 9-hydroxy metabolite. | Human psychopharmacology 20061201 |
| Restoration of bile ducts in drug-induced vanishing bile duct syndrome due to zonisamide. | The American journal of surgical pathology 20061201 |
| Comorbidity of eating disorders with bipolar disorder and treatment implications. | Bipolar disorders 20061201 |
| Endothelin receptor antagonism in pulmonary arterial hypertension--a role for selective ET(A) inhibition? | Current medical research and opinion 20061201 |
| The effect of leflunomide analogue FK778 on development of chronic rat renal allograft rejection and transforming growth factor-BETA expression. | Transplantation proceedings 20061201 |
| Prevalence and clinical course of BK virus nephropathy in pancreas after kidney transplant patients. | Transplantation proceedings 20061201 |
| Indications for acceleration-dependent changes of membrane potential in the flagellate Euglena gracilis. | Protoplasma 20061201 |
| Oxidation of sulfonamide antimicrobials by ferrate(VI) [Fe(VI)O4(2-)]. | Environmental science & technology 20061201 |
| Zonisamide in the treatment of binge eating disorder with obesity: a randomized controlled trial. | The Journal of clinical psychiatry 20061201 |
| Synthetic inhibitors of cytochrome P-450 2A6: inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization. | Journal of medicinal chemistry 20061130 |
| Leflunomide or A77 1726 protect from acetaminophen-induced cell injury through inhibition of JNK-mediated mitochondrial permeability transition in immortalized human hepatocytes. | Toxicology and applied pharmacology 20061115 |
| Reversal of regioselectivity and enhancement of rates of nitrile oxide cycloadditions through transient attachment of dipolarophiles to cyclodextrins. | Chemistry (Weinheim an der Bergstrasse, Germany) 20061115 |
| The effect of different antioxidants on glutathione turnover in human cell lines and their interaction with hydrogen peroxide. | Chemico-biological interactions 20061107 |
| Increased disease activity is associated with a deteriorated lipid profile in patients with ankylosing spondylitis. | Annals of the rheumatic diseases 20061101 |
| Lysophosphatidic acid as a mediator for proinflammatory agonists in a human corneal epithelial cell line. | American journal of physiology. Cell physiology 20061101 |
| An analgesic model for assessment of acute pain response in osteoarthritis of the knee. | Osteoarthritis and cartilage 20061101 |
| Influence of leflunomide on gastrointestinal Candida albicans infection induced in naive and arthritic newborn mice. | International immunopharmacology 20061101 |
| Effects of nitric oxide synthase inhibition with or without cyclooxygenase-2 inhibition on resting haemodynamics and responses to exendin-4. | British journal of pharmacology 20061101 |
| The effects of paracetamol and parecoxib on kidney function in elderly patients undergoing orthopedic surgery. | Anesthesia and analgesia 20061101 |
| Modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by parecoxib in humans. | Anesthesiology 20061101 |
| [Spondylarthritides]. | Zeitschrift fur Rheumatologie 20061101 |
| Leflunomide-induced toxic epidermal necrolysis. | International journal of dermatology 20061101 |
| Prevention of renal ischemia/reperfusion-induced injury in rats by leflunomide. | International journal of urology : official journal of the Japanese Urological Association 20061101 |
| A long-term follow-up of zonisamide monotherapy. | Epilepsia 20061101 |
| The active metabolite of leflunomide, A77 1726, increases proliferation of human synovial fibroblasts in presence of IL-1beta and TNF-alpha. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20061101 |
| [New medications; zonisamide]. | Nederlands tijdschrift voor geneeskunde 20061021 |
| Decomposition and isomerization of 1,2-benzisoxazole: single-pulse shock-tube experiments, quantum chemical and transition-state theory calculations. | The journal of physical chemistry. A 20061019 |
| Stabilization and determination of a PPAR agonist in human urine using automated 96-well liquid-liquid extraction and liquid chromatography/tandem mass spectrometry. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20061002 |
| Leflunomide increases the risk of early healing complications in patients with rheumatoid arthritis undergoing elective orthopedic surgery. | Rheumatology international 20061001 |
| [Analgesia in colon surgery. Can the use of NSAIDs reduce the opioid consumption following conventional and laparoscopic interventions?]. | Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen 20061001 |
| Zonisamide eradicated paroxysmal headache with EEG abnormalities triggered by hypertensive encephalopathy due to purpura nephritic syndrome. | Brain & development 20061001 |
| Low dose leflunomide activates PI3K/Akt signalling in erythroleukemia cells and reduces apoptosis induced by anticancer agents. | Apoptosis : an international journal on programmed cell death 20061001 |
| Prostacyclin production in tryptase and thrombin stimulated human bladder endothelial cells: effect of pretreatment with phospholipase A2 and cyclooxygenase inhibitors. | The Journal of urology 20061001 |
| Zonisamide for migraine prophylaxis in refractory patients. | Cephalalgia : an international journal of headache 20061001 |
| Angioinvasive aspergillosis presenting as neutropenic colitis. | Histopathology 20061001 |
| Suppression of azoxymethane-induced colon cancer development in rats by a cyclooxygenase-1 selective inhibitor, mofezolac. | Cancer science 20061001 |
| The associations between severity of early postoperative pain, chronic postsurgical pain and plasma concentration of stable nitric oxide products after breast surgery. | Anesthesia and analgesia 20061001 |
| Polymorphisms of the ABCB1 gene are associated with the therapeutic response to risperidone in Chinese schizophrenia patients. | Pharmacogenomics 20061001 |
| The effect of FK778 on acute rat renal allograft rejection and expression of platelet-derived growth factor and transforming growth factor-beta. | Transplantation proceedings 20061001 |
| Trying times for painkiller choices. Vioxx, Bextra, and Celebrex can increase the risk for heart attack and other cardiovascular problems. So can the old standbys, like ibuprofen and acetaminophen. | Harvard heart letter : from Harvard Medical School 20061001 |
| Field dissipation and environmental hazard assessment of clomazone, molinate, and thiobencarb in Australian rice culture. | Journal of agricultural and food chemistry 20060920 |
| Medical therapy: where are we now? | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20060915 |
| KRN951, a highly potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, has antitumor activities and affects functional vascular properties. | Cancer research 20060915 |
| Effects of clomazone herbicide on hematological and some parameters of protein and carbohydrate metabolism of silver catfish Rhamdia quelen. | Ecotoxicology and environmental safety 20060901 |
| Chronic pain and sensory changes after augmentation mammoplasty: long term effects of preincisional administration of methylprednisolone. | Pain 20060901 |
| Iloperidone reduces sensorimotor gating deficits in pharmacological models, but not a developmental model, of disrupted prepulse inhibition in rats. | Neuropharmacology 20060901 |
| Substituent effects on 15N and 13C NMR chemical shifts of 3-phenylisoxazoles: a theoretical and spectroscopic study. | Magnetic resonance in chemistry : MRC 20060901 |
| Evaluation of antipsychotic drugs as inhibitors of multidrug resistance transporter P-glycoprotein. | Psychopharmacology 20060901 |
| Parecoxib impairs early metaphyseal bone healing in rats. | Archives of orthopaedic and trauma surgery 20060901 |
| Successful treatment with leflunomide of arthritis in systemic sclerosis patients. | Rheumatology (Oxford, England) 20060901 |
| Cyclooxygenase type 2 is increased in obstructed rat and human ureter and contributes to pelvic pressure increase after obstruction. | Kidney international 20060901 |
| Hepatic damage in biliary-obstructed rats is ameliorated by leflunomide treatment. | Pediatric surgery international 20060901 |
| An evidence-based approach to the management of pulmonary arterial hypertension. | Current opinion in cardiology 20060901 |
| Pulmonary alveolar proteinosis associated with a disease-modifying antirheumatoid arthritis drug. | Respirology (Carlton, Vic.) 20060901 |
| Dual ET(A)/ET(B) vs. selective ET(A) endothelin receptor antagonism in patients with pulmonary hypertension. | European journal of clinical investigation 20060901 |
| Parecoxib--getting to the heart of the matter. | Anaesthesia 20060901 |
| Lack of analgesic effect of parecoxib following laparoscopic cholecystectomy. | Acta anaesthesiologica Scandinavica 20060901 |
| Valdecoxib for postoperative pain management after cesarean delivery: a randomized, double-blind, placebo-controlled study. | Anesthesia and analgesia 20060901 |
| Protean agonism of the lysophosphatidic acid receptor-1 with Ki16425 reduces nerve growth factor-induced neurite outgrowth in pheochromocytoma 12 cells. | Journal of neurochemistry 20060901 |
| Formulation and evaluation of Nanostructured Lipid Carrier (NLC)-based gel of Valdecoxib. | Drug development and industrial pharmacy 20060901 |
| Leflunomide for relapsing polychondritis: successful longterm treatment. | The Journal of rheumatology 20060901 |
| Valdecoxib does not interfere with the CYP2D6 substrate metoprolol. | International journal of clinical pharmacology and therapeutics 20060901 |
| Zonisamide for the treatment of epilepsy. | Expert review of neurotherapeutics 20060901 |
| Enhancement of dissolution profile by solid dispersion (kneading) technique. | AAPS PharmSciTech 20060901 |
| [What do we know about the cardiovascular toxicity of the NSAIDs?]. | Presse medicale (Paris, France : 1983) 20060901 |
| [Are there any differences in the cardiovascular tolerance between classical NSAIDs and coxibs?]. | Presse medicale (Paris, France : 1983) 20060901 |
| Biological targets for therapeutic interventions in COPD: clinical potential. | International journal of chronic obstructive pulmonary disease 20060901 |
| Replacement of the metabolically labile methyl esters in the alkenyldiarylmethane series of non-nucleoside reverse transcriptase inhibitors with isoxazolone, isoxazole, oxazolone, or cyano substituents. | Journal of medicinal chemistry 20060824 |
| Integrin signalling regulates the nuclear localization and function of the lysophosphatidic acid receptor-1 (LPA1) in mammalian cells. | The Biochemical journal 20060815 |
| Antirheumatic drug use and the risk of acute myocardial infarction. | Arthritis and rheumatism 20060815 |
| Cyclooxygenase-2 inhibitors enhance shear stress-induced platelet aggregation. | Journal of the American College of Cardiology 20060815 |
| COX-2 inhibitors and early failure of free vascular flaps. | The New England journal of medicine 20060803 |
| Constitutive cyclo-oxygenase-2 does not contribute to the development of human visceral pain hypersensitivity. | European journal of pain (London, England) 20060801 |
| THIP, a hypnotic and antinociceptive drug, enhances an extrasynaptic GABAA receptor-mediated conductance in mouse neocortex. | Cerebral cortex (New York, N.Y. : 1991) 20060801 |
| Reversible binding of celecoxib and valdecoxib with human serum albumin using fluorescence spectroscopic technique. | Pharmacological research 20060801 |
| QF2004B, a potential antipsychotic butyrophenone derivative with similar pharmacological properties to clozapine. | Neuropharmacology 20060801 |
| Influence on platelet aggregation of i.v. parecoxib and acetaminophen in healthy volunteers. | British journal of anaesthesia 20060801 |
| An open prospective study of zonisamide in acute bipolar depression. | Journal of clinical psychopharmacology 20060801 |
| Zonisamide-induced mania in an essential tremor patient. | Journal of clinical psychopharmacology 20060801 |
| Efficacy and safety of leflunomide alone and in combination with methotrexate in the treatment of refractory rheumatoid arthritis. | Indian journal of medical sciences 20060801 |
| The COX-2 inhibitors--an update. | American heart journal 20060801 |
| Preparation, characterization and in vitro dissolution studies of solid systems of valdecoxib with chitosan. | Chemical & pharmaceutical bulletin 20060801 |
| Inhibition of cyclooxygenase-2 in experimental severe acute pancreatitis. | Clinics (Sao Paulo, Brazil) 20060801 |
| [Paliperidone]. | Medizinische Monatsschrift fur Pharmazeuten 20060801 |
| Real-time and high throughput monitoring of cAMP in live cells using a fluorescent membrane potential-sensitive dye. | Assay and drug development technologies 20060801 |
| How specific are 'target-specific' drugs? Celecoxib as a case in point. | Molecular interventions 20060801 |
| Fluorinated acyclo-C-nucleoside analogues from glycals in two steps. | Carbohydrate research 20060724 |
| Endothelin receptor antagonists for pulmonary arterial hypertension. | The Cochrane database of systematic reviews 20060719 |
| delta-Subunit containing GABAA receptor knockout mice are less sensitive to the actions of 4,5,6,7-tetrahydroisoxazolo-[5,4-c]pyridin-3-ol. | European journal of pharmacology 20060717 |
| Pregnane X receptor is a target of farnesoid X receptor. | The Journal of biological chemistry 20060714 |
| Discovery of potent and orally available malonyl-CoA decarboxylase inhibitors as cardioprotective agents. | Journal of medicinal chemistry 20060713 |
| Leflunomide/chloroquin combination therapy in rheumatoid arthritis: a pilot study. | Clinical rheumatology 20060701 |
| Constitutive and activation-inducible cyclooxygenase-2 expression enhances survival of chronic lymphocytic leukemia B cells. | Clinical immunology (Orlando, Fla.) 20060701 |
| Lysophosphatidic acid induces chemotaxis in MC3T3-E1 osteoblastic cells. | Bone 20060701 |
| Synthesis of enantiopure Delta2-isoxazoline derivatives and evaluation of their affinity and efficacy profiles at human beta-adrenergic receptor subtypes. | Bioorganic & medicinal chemistry 20060701 |
| Synthesis of 7-amino-3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazole derivatives displaying combined alpha2-adrenoceptor antagonistic and 5-HT reuptake inhibiting activities. | Bioorganic & medicinal chemistry 20060701 |
| Induction of regulatory T cells by leflunomide in a murine model of contact allergen sensitivity. | The Journal of investigative dermatology 20060701 |
| Copper complexes with heterocyclic sulfonamides: synthesis, spectroscopic characterization, microbiological and SOD-like activities: crystal structure of [Cu(sulfisoxazole)2(H2O)4] . 2H2O. | Journal of inorganic biochemistry 20060701 |
| Remission of polyomavirus-induced graft nephropathy treated with low-dose leflunomide. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20060701 |
| Critical modifications of the ISO-1 scaffold improve its potent inhibition of macrophage migration inhibitory factor (MIF) tautomerase activity. | Bioorganic & medicinal chemistry letters 20060701 |
| How is leflunomide prescribed and used in Australia? Analysis of prescribing and adverse effect reporting. | Pharmacoepidemiology and drug safety 20060701 |
| Leflunomide--an immunomodulator--induces regression of endometrial explants in a rat model of endometriosis. | Journal of the Society for Gynecologic Investigation 20060701 |
| Severe infections following leflunomide therapy for rheumatoid arthritis. | Rheumatology (Oxford, England) 20060701 |
| An evidence-based approach to the management of pulmonary arterial hypertension. | Current opinion in cardiology 20060701 |
| Serum concentrations of risperidone and 9-OH risperidone following intramuscular injection of long-acting risperidone compared with oral risperidone medication. | Acta psychiatrica Scandinavica 20060701 |
| The efficacy of the non-opioid analgesics parecoxib, paracetamol and metamizol for postoperative pain relief after lumbar microdiscectomy. | Anesthesia and analgesia 20060701 |
| Lysophosphatidic acid cooperates with 1alpha,25(OH)2D3 in stimulating human MG63 osteoblast maturation. | Prostaglandins & other lipid mediators 20060701 |
| Subcellular localization and possible functions of gamma-glutamyltransferase in the radish (Raphanus sativus L.) plant. | Bioscience, biotechnology, and biochemistry 20060701 |
| Forced-degradation study of valdecoxib as bulk drug and in tablet formulation by HPTLC. | Journal of separation science 20060701 |
| [Cyclooxygenase inhibitors: a never ending story?]. | Giornale italiano di cardiologia (2006) 20060701 |
| Rofecoxib 50 mg and valdecoxib 20 or 40 mg in adults and adolescents with postoperative pain after third molar extraction: results of two randomized, double-blind, placebo-controlled, single-dose studies. | Clinical therapeutics 20060701 |
| Novel mutants of the human beta1-adrenergic receptor reveal amino acids relevant for receptor activation. | The Journal of biological chemistry 20060630 |
| Determination of zonisamide by a coated monolithic column. | Journal of chromatography. A 20060616 |
| Simultaneous determination of zonisamide, carbamazepine and carbamazepine-10,11-epoxide in infant serum by high-performance liquid chromatography. | Journal of pharmaceutical and biomedical analysis 20060616 |
| Isoxazole-type derivatives related to combretastatin A-4, synthesis and biological evaluation. | Bioorganic & medicinal chemistry 20060615 |
| Synthesis of pyrazoles and isoxazoles as potent alpha(v)beta3 receptor antagonists. | Bioorganic & medicinal chemistry letters 20060615 |
| [Drug induced lung injuries in Japanese population]. | Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20060610 |
| [Diagnosis of and therapy for diffuse lung diseases (discussion)]. | Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20060610 |
| Anti-inflammatory effects of leflunomide in combination with methotrexate on co-culture of T lymphocytes and synovial macrophages from rheumatoid arthritis patients. | Annals of the rheumatic diseases 20060601 |
| The COX-2 specific inhibitor Valdecoxib versus tramadol in acute ankle sprain: a multicenter randomized, controlled trial. | The American journal of sports medicine 20060601 |
| Synthesis and biological evaluation of phosphonated dihydroisoxazole nucleosides. | Bioorganic & medicinal chemistry 20060601 |
| Leflunomide and methotrexate combination therapy in daily clinical practice. | Annals of the rheumatic diseases 20060601 |
| Leflunomide and warfarin interaction: case report and review of the literature. | Pharmacotherapy 20060601 |
| Efficacy of a selective COX-2 inhibitor for controlling irregular uterine bleeding in DMPA users. | Contraception 20060601 |
| Polyomavirus-associated nephropathy: update on antiviral strategies. | Transplant infectious disease : an official journal of the Transplantation Society 20060601 |
| Positive modulation of glutamatergic receptors potentiates the suppressive effects of antipsychotics on conditioned avoidance responding in rats. | Pharmacology, biochemistry, and behavior 20060601 |
| Synthesis of the pyrazole isostere of valdecoxib. | Die Pharmazie 20060601 |
| Pharmacokinetics and bioequivalence evaluation of risperidone in healthy male subjects with different CYP2D6 genotypes. | Archives of pharmacal research 20060601 |
| Substrates induce conformational changes in human anion exchanger 1 (hAE1) as observed by fluorescence resonance energy transfer. | Biochemistry 20060523 |
| Treatment of pulmonary arterial hypertension with the selective endothelin-A receptor antagonist sitaxsentan. | Journal of the American College of Cardiology 20060516 |
| Rheumatoid lung nodulosis and osteopathy associated with leflunomide therapy. | Clinical rheumatology 20060501 |
| Long-term efficacy and safety of monotherapy and adjunctive therapy with zonisamide. | Epilepsy & behavior : E&B 20060501 |
| Protective effects of leflunomide against ischemia-reperfusion injury of the rat liver. | Pediatric surgery international 20060501 |
| Polymorphism on leflunomide: stability and crystal structures. | Journal of pharmaceutical sciences 20060501 |
| Prostaglandin I2 release following mesenteric traction during abdominal surgery is mediated by cyclooxygenase-1. | European journal of pharmacology 20060501 |
| Recent developments in the treatment of adult atopic dermatitis. | The Australasian journal of dermatology 20060501 |
| Zonisamide prophylaxis in refractory pediatric headache. | Headache 20060501 |
| Leflunomide use and the risk of interstitial lung disease in rheumatoid arthritis. | Arthritis and rheumatism 20060501 |
| Efficacy and safety of zonisamide monotherapy in a cohort of children with epilepsy. | Pediatric neurology 20060501 |
| Safety of infliximab used in combination with leflunomide or azathioprine in daily clinical practice. | The Journal of rheumatology 20060501 |
| Evidence of a new dechlorinated ochratoxin A derivative formed in opossum kidney cell cultures after pretreatment by modulators of glutathione pathways: correlation with DNA-adduct formation. | Molecular nutrition & food research 20060501 |
| Parecoxib tolerability in patients with hypersensitivity to nonsteroidal anti-inflammatory drugs. | The Journal of allergy and clinical immunology 20060501 |
| Leflunomide: a possible alternative for gangciclovir sensitive and resistant cytomegalovirus infections. | Postgraduate medical journal 20060501 |
| Formulation of solid dosage forms to overcome gastric pH interaction of the factor Xa inhibitor, BMS-561389. | Pharmaceutical research 20060501 |
| Valdecoxib exposures reported to Texas poison centers during 2002-2004. | Journal of toxicology and environmental health. Part A 20060501 |
| Anti-Jo-1 antibody positive polymyositis--successful therapy with leflunomide. | Autoimmunity 20060501 |
| Prolonged psychosis after Amanita muscaria ingestion. | Wiener klinische Wochenschrift 20060501 |
| [An animal model of antiepileptic-induced osteoporosis in rats]. | Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20060501 |
| The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice. | The Journal of biological chemistry 20060421 |
| Pharmacologic transglutaminase inhibition attenuates drug-primed liver hypertrophy but not Mallory body formation. | FEBS letters 20060417 |
| Synthesis of novel benzofuran isoxazolines as protein tyrosine phosphatase 1B inhibitors. | Bioorganic & medicinal chemistry letters 20060415 |
| Extrasynaptic GABAA receptors are critical targets for sedative-hypnotic drugs. | Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 20060415 |
| Practical asymmetric synthesis of a gamma-secretase inhibitor exploiting substrate-controlled intramolecular nitrile oxide-olefin cycloaddition. | The Journal of organic chemistry 20060414 |
| 4-Alkoxycarbonyl- and aminocarbonyl-substituted isoxazoles as masked acrylates and acrylamides in the asymmetric synthesis of delta2-isoxazolines. | The Journal of organic chemistry 20060414 |
| COX-2 inhibitors and pain after oral surgery - pertinent papers 2002-2003. | The British journal of oral & maxillofacial surgery 20060401 |
| Synthesis and anti-HIV activity of new alkenyldiarylmethane (ADAM) non-nucleoside reverse transcriptase inhibitors (NNRTIs) incorporating benzoxazolone and benzisoxazole rings. | Bioorganic & medicinal chemistry 20060401 |
| Effects of COX-1 and COX-2 inhibitors on the firing of rat midbrain dopaminergic neurons--possible involvement of endogenous kynurenic acid. | Synapse (New York, N.Y.) 20060401 |
| Does preoperatively administered parecoxib prevent succinylcholine-associated myalgia? A randomized, placebo-controlled trial. | European journal of anaesthesiology 20060401 |
| Sirolimus and FK778: a comparison of two anti-proliferative immunosuppressants for prevention of experimental obliterative airway disease. | Transplant international : official journal of the European Society for Organ Transplantation 20060401 |
| New targets in and potential treatments for cholesterol gallstone disease. | Current opinion in investigational drugs (London, England : 2000) 20060401 |
| Products of cyclooxygenase-2 depress duodenal function in rats subjected to abdominal surgery. | Acta physiologica (Oxford, England) 20060401 |
| [Skin ulceration after leflunomide treatment in two patients with rheumatoid arthritis]. | Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 20060401 |
| FK778: new cellular and molecular mechanisms of action. | Transplantation proceedings 20060401 |
| Randomised controlled trial of leflunomide in the treatment of immunoglobulin A nephropathy. | Nephrology (Carlton, Vic.) 20060401 |
| [Clinical observation on effects of leflunomid and total glucosides of paeony on rheumatoid arthritis]. | Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20060401 |
| [Drug-induced lichenoid eruptions]. | Annales de dermatologie et de venereologie 20060401 |
| Severe atopic dermatitis and leflunomide: first clinical experience and highlights of pertinent experimental data. | Dermatology online journal 20060330 |
| A Phase II study of the safety and efficacy of teriflunomide in multiple sclerosis with relapses. | Neurology 20060328 |
| Synthesis of enantiopure indolizinones by cascade ring enlargements of 4'-chlorospiro[cyclopropane-1,5'-isoxazolidines]. | The Journal of organic chemistry 20060317 |
| Diazocinones: synthesis and conformational analysis. | The Journal of organic chemistry 20060317 |
| Leflunomide prevents alveolar fluid clearance inhibition by respiratory syncytial virus. | American journal of respiratory and critical care medicine 20060315 |
| Treatment of renal allograft polyoma BK virus infection with leflunomide. | Transplantation 20060315 |
| Synthetic heteroprostanoids of A- and E-types as novel non-comprehensive inhibitors of adenylyl cyclase in rat hepatocytes. | Biochemical and biophysical research communications 20060310 |
| Intestinal uptake and biodistribution of novel polymeric micelles after oral administration. | Journal of controlled release : official journal of the Controlled Release Society 20060310 |
| The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes. | American journal of physiology. Gastrointestinal and liver physiology 20060301 |
| Pharmacological characterization of agonists at delta-containing GABAA receptors: Functional selectivity for extrasynaptic receptors is dependent on the absence of gamma2. | The Journal of pharmacology and experimental therapeutics 20060301 |
| In vitro anti-inflammatory activities of new steroidal antedrugs: [16alpha,17alpha-d] Isoxazoline and [16alpha,17alpha-d]-3'-hydroxy-iminoformyl isoxazoline derivatives of prednisolone and 9alpha-fluoroprednisolone. | Steroids 20060301 |
| The basic secretagogue compound 48/80 activates G proteins indirectly via stimulation of phospholipase D-lysophosphatidic acid receptor axis and 5-HT1A receptors in rat brain sections. | British journal of pharmacology 20060301 |
| Emerging therapies in juvenile rheumatoid/idiopathic arthritis. | Current problems in pediatric and adolescent health care 20060301 |
| Safety and efficacy of leflunomide in the treatment of lupus nephritis refractory or intolerant to traditional immunosuppressive therapy: an open label trial. | Annals of the rheumatic diseases 20060301 |
| Multiple dose pharmacokinetics of risperidone and 9-hydroxyrisperidone in Chinese female patients with schizophrenia. | Acta pharmacologica Sinica 20060301 |
| Pneumonitis associated with leflunomide: a profile of New Zealand and Australian reports. | Internal medicine journal 20060301 |
| Safety and efficacy of the cyclooxygenase-2 inhibitors parecoxib and valdecoxib after noncardiac surgery. | Anesthesiology 20060301 |
| Lysophosphatidic acid is a major regulator of growth-regulated oncogene alpha in ovarian cancer. | Cancer research 20060301 |
| Combination of cyclosporine and leflunomide versus single therapy in severe rheumatoid arthritis. | The Journal of rheumatology 20060301 |
| A PET study evaluating dopamine D2 receptor occupancy for long-acting injectable risperidone. | The American journal of psychiatry 20060301 |
| Evaluation of preemptive valdecoxib therapy on initial archwire placement discomfort in adults. | The Angle orthodontist 20060301 |
| Determination of valdecoxib in serum using a HPLC-diode array detector and its application in a pharmacokinetic study. | Die Pharmazie 20060301 |
| Treatment of multidrug-resistant cytomegalovirus retinitis with systemically administered leflunomide. | Transplant infectious disease : an official journal of the Transplantation Society 20060301 |
| A multicenter, randomized, double-blind, active-comparator, placebo-controlled, parallel-group comparison of the incidence of endoscopic gastric and duodenal ulcer rates with valdecoxib or naproxen in healthy subjects aged 65 to 75 years. | Clinical therapeutics 20060301 |
| Involvement of GABAergic modulation of antinociception induced by morphine microinjected into the ventrolateral orbital cortex. | Brain research 20060216 |
| Rapid assembly and in situ screening of bidentate inhibitors of protein tyrosine phosphatases. | Organic letters 20060216 |
| Pharmacokinetics and metabolism studies on (3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy) pyrazolo[1,5-d][1,2,4]triazine, a functionally selective GABA(A) alpha5 inverse agonist for cognitive dysfunction. | Bioorganic & medicinal chemistry letters 20060215 |
| Different roles of liver X receptor alpha and beta in lipid metabolism: effects of an alpha-selective and a dual agonist in mice deficient in each subtype. | Biochemical pharmacology 20060214 |
| Iterative, aqueous synthesis of beta3-oligopeptides without coupling reagents. | Journal of the American Chemical Society 20060208 |
| Differential mechanisms of glutamate receptor regulation of SynGAP in cortical neurones. | FEBS letters 20060206 |
| Studies on LXR- and FXR-mediated effects on cholesterol homeostasis in normal and cholic acid-depleted mice. | Journal of lipid research 20060201 |
| A role for FXR and human FGF-19 in the repression of paraoxonase-1 gene expression by bile acids. | Journal of lipid research 20060201 |
| Zonisamide as adjunctive therapy for refractory partial seizures. | Epilepsy research 20060201 |
| Leflunomide-associated tuberculosis? | Rheumatology (Oxford, England) 20060201 |
| Zonisamide in the management of epilepsy--Japanese experience. | Epilepsy research 20060201 |
| Single dose parecoxib significantly improves ventilatory function in early extubation coronary artery bypass surgery: a prospective randomized double blind placebo controlled trial. | British journal of anaesthesia 20060201 |
| Gaboxadol--a new awakening in sleep. | Current opinion in pharmacology 20060201 |
| Physico-chemical characterization of disoxaril-dimethyl-beta-cyclodextrin inclusion complex and in vitro permeation studies. | European journal of medicinal chemistry 20060201 |
| BK virus nephritis after renal transplantation. | Kidney international 20060201 |
| Practical prescribing and long-term efficacy and safety of zonisamide. | Epilepsy research 20060201 |
| Introduction to zonisamide. | Epilepsy research 20060201 |
| Post-anoxic myoclonus: a case presentation and review of management in the rehabilitation setting. | Brain injury 20060201 |
| Methylprednisolone reduces pain, emesis, and fatigue after breast augmentation surgery: a single-dose, randomized, parallel-group study with methylprednisolone 125 mg, parecoxib 40 mg, and placebo. | Anesthesia and analgesia 20060201 |
| Safety of cox-2 selective nonsteroidal antiinflammatory drugs for postsurgical pain. | Anesthesia and analgesia 20060201 |
| Postsurgical safety of opioid-sparing cyclooxygenase-2 inhibitors. | Anesthesiology 20060201 |
| Treatment for rheumatoid arthritis and the risk of hospitalization for pneumonia: associations with prednisone, disease-modifying antirheumatic drugs, and anti-tumor necrosis factor therapy. | Arthritis and rheumatism 20060201 |
| Ocular adverse effects associated with cyclooxygenase-2 inhibitors. | Archives of ophthalmology (Chicago, Ill. : 1960) 20060201 |
| Effects of parecoxib on plasma protein extravasation and c-fos expression in the rat. | Headache 20060201 |
| A comparison of valdecoxib and naproxen in the treatment of rheumatoid arthritis symptoms. | Clinical therapeutics 20060201 |
| Substituted isoxazoles as potent inhibitors of p38 MAP kinase. | ChemMedChem 20060201 |
| Dopamine release in human neocortical slices: characterization of inhibitory autoreceptors and of nicotinic acetylcholine receptor-evoked release. | Brain research bulletin 20060130 |
| Synthesis and biological activity of isoxazolidinyl polycyclic aromatic hydrocarbons: potential DNA intercalators. | Journal of medicinal chemistry 20060126 |
| Determination of leflunomide in tablets by high performance liquid chromatography. | Journal of pharmaceutical and biomedical analysis 20060123 |
| The effects of leflunomide on clinical parameters and serum levels of IL-6, IL-10, MMP-1 and MMP-3 in patients with resistant rheumatoid arthritis. | Cytokine 20060121 |
| Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II 'selective' inhibitor celecoxib. | Bioorganic & medicinal chemistry letters 20060115 |
| Combination therapy using the cyclooxygenase-2 inhibitor Parecoxib and radioimmunotherapy in nude mice with small peritoneal metastases of colonic origin. | Cancer immunology, immunotherapy : CII 20060101 |
| Simultaneous quantitation of etoricoxib, salicylic acid, valdecoxib, ketoprofen, nimesulide and celecoxib in plasma by high-performance liquid chromatography with UV detection. | Biomedical chromatography : BMC 20060101 |
| Lysophosphatidic acid (LPA)-induced vascular endothelial growth factor (VEGF) by mesothelial cells and quantification of host-derived VEGF in malignant ascites. | The Journal of surgical research 20060101 |
| FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine. | Journal of lipid research 20060101 |
| Advances in the therapy of Wegener's granulomatosis. | Current opinion in rheumatology 20060101 |
| Zonisamide-induced suicidal ideation. | Psychosomatics 20060101 |
| Spray dried excipient base: a novel technique for the formulation of orally disintegrating tablets. | Chemical & pharmaceutical bulletin 20060101 |
| Impact of epsilon and theta subunits on pharmacological properties of alpha3beta1 GABAA receptors expressed in Xenopus oocytes. | BMC pharmacology 20060101 |
| Pharmacologic treatment of obesity. | Advances in psychosomatic medicine 20060101 |
| Concurrent antiviral and immunosuppressive activities of leflunomide in vivo. | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20060101 |
| [Antimicrobial therapy in dermatology]. | Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 20060101 |
| A novel selective gamma-aminobutyric acid transport inhibitor demonstrates a functional role for GABA transporter subtype GAT2/BGT-1 in the CNS. | Neurochemistry international 20060101 |
| Coxibs and cardiovascular side-effects: from light to shadow. | Current pharmaceutical design 20060101 |
| The active form of leflunomide, HMR1726, facilitates TNF-alpha and IL-17 induced MMP-1 and MMP-3 expression. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20060101 |
| Leflunomide improves psoriasis in patients with psoriatic arthritis: an in-depth analysis of data from the TOPAS study. | Dermatology (Basel, Switzerland) 20060101 |
| Prototypical antipsychotic drugs protect hippocampal neuronal cultures against cell death induced by growth medium deprivation. | BMC neuroscience 20060101 |
| Drug monitoring and toxicology: a procedure for the monitoring of levetiracetam and zonisamide by HPLC-UV. | Journal of analytical toxicology 20060101 |
| Disseminating drug prescribing information: the cox-2 inhibitors withdrawals. | Journal of the American Medical Informatics Association : JAMIA 20060101 |
| Leflunomide in solid organ transplantation and polyoma virus infection. | Advances in experimental medicine and biology 20060101 |
| Treatment of refractory CMV-infection following hematopoietic stem cell transplantation with the combination of foscarnet and leflunomide. | Klinische Padiatrie 20060101 |
| Endogenous endophthalmitis by Propionibacterium acnes associated with leflunomide and adalimumab therapy. | European journal of ophthalmology 20060101 |
| Can selective ligands for glutamate binding proteins be rationally designed? | Current topics in medicinal chemistry 20060101 |
| Inhibitory effects of leflunomide therapy on the activity of matrixmetalloproteinase-9 and the release of cartilage oligomeric matrix protein in patients with rheumatoid arthritis. | Clinical and experimental rheumatology 20060101 |
| Suppression of circulating interleukin-6 concentrations is associated with decreased endothelial activation in rheumatoid arthritis. | Clinical and experimental rheumatology 20060101 |
| Leflunomide in rheumatoid arthritis in daily practice: treatment discontinuation rates in comparison with other DMARDs. | Clinical and experimental rheumatology 20060101 |
| Liquid chromatography/tandem mass spectrometry method for simultaneous determination of risperidone and its active metabolite 9-hydroxyrisperidone in human plasma. | Rapid communications in mass spectrometry : RCM 20060101 |
| Leflunomide-induced pneumonitis in a patient with rheumatoid arthritis. | Internal medicine (Tokyo, Japan) 20060101 |
| Host resistance to Candida albicans infection of mice with collagen-induced arthritis treated with leflunomide. | Research in microbiology 20060101 |
| Pulmonary hypertension in older children: new approaches and therapies. | Paediatric respiratory reviews 20060101 |
| Role of FK778 alone or in combination with tacrolimus or mTOR inhibitors as an immunomodulator of immunofunctions: in vitro evaluation of T cell proliferation and the expression of lymphocyte surface antigens. | International journal of immunopathology and pharmacology 20060101 |
| Severe cutaneous adverse drug reaction to leflunomide: a report of five cases. | Indian journal of dermatology, venereology and leprology 20060101 |
| [An antidestructive effect of leflunomide in early rheumatoid arthritis]. | Terapevticheskii arkhiv 20060101 |
| FK778 does not impair intestinal allograft absorption in a preclinical model of total small bowel transplantation. | Transplantation proceedings 20060101 |
| FK778 and tacrolimus combination therapy to control acute rejection after pig intestinal transplantation. | Transplantation proceedings 20060101 |
| Sorption of isoxaflutole diketonitrile degradate (DKN) and dicamba in unsaturated soil. | Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 20060101 |
| Analgesic efficacy of valdecoxib for acute postoperative pain after bunionectomy. | Journal of the American Podiatric Medical Association 20060101 |
| Responding rapidly to FDA drug withdrawals: design and application of a new approach for a consumer health website. | Journal of medical Internet research 20060101 |
| Leflunomide-related acute interstitial pneumonia in two patients with rheumatoid arthritis: autopsy findings with a mosaic pattern of acute and organizing diffuse alveolar damage. | Modern rheumatology 20060101 |
| Pharmacokinetic variability of newer antiepileptic drugs: when is monitoring needed? | Clinical pharmacokinetics 20060101 |
| Leflunomide in clinical practice. | Acta reumatologica portuguesa 20060101 |
| Valdecoxib provides effective pain relief following acute ankle sprain. | The Journal of international medical research 20060101 |
| Interaction of non-steroidal anti-inflammatory drugs, etoricoxib and parecoxib sodium, with human serum albumin studied by fluorescence spectroscopy. | Drug metabolism and drug interactions 20060101 |
| [Usage of the new parenteral selective cox-2 inhibitor dynastat in the gynecologic practice]. | Akusherstvo i ginekologiia 20060101 |
| Spectrophotometric stability-indicating methods for the determination of leflunomide in the presence of its degradates. | Journal of AOAC International 20060101 |
| Influence of an adjuvant on the distribution of herbicides in a sediment/water system. | Communications in agricultural and applied biological sciences 20060101 |
| Differential response of chickpea genotypes to isoxaflutole. | Communications in agricultural and applied biological sciences 20060101 |
| [Rational therapeutic approach in rheumatoid arthritis]. | Annales Academiae Medicae Stetinensis 20060101 |
| An integrated approach to developing chemoenzymatic processes at the industrial scale. | Ernst Schering Foundation symposium proceedings 20060101 |
| Novel indole-based peroxisome proliferator-activated receptor agonists: design, SAR, structural biology, and biological activities. | Journal of medicinal chemistry 20051229 |
| Blocking tumor cell migration and invasion with biphenyl isoxazole derivative KRIBB3, a synthetic molecule that inhibits Hsp27 phosphorylation. | The Journal of biological chemistry 20051216 |
| Cyclohexyl-linked tricyclic isoxazoles are potent and selective modulators of the multidrug resistance protein (MRP1). | Bioorganic & medicinal chemistry letters 20051215 |
| Thyroid hormone stimulates gamma-glutamyl transpeptidase in the developing rat cerebra and in astroglial cultures. | Journal of neuroscience research 20051215 |
| Double blind, randomised, placebo controlled study of leflunomide in the treatment of active ankylosing spondylitis. | Annals of the rheumatic diseases 20051201 |
| Lethal pneumonitis under leflunomide therapy. | Rheumatology (Oxford, England) 20051201 |
| An extrasynaptic GABAA receptor mediates tonic inhibition in thalamic VB neurons. | Journal of neurophysiology 20051201 |
| Species differences in the elimination of a peroxisome proliferator-activated receptor agonist highlighted by oxidative metabolism of its acyl glucuronide. | Drug metabolism and disposition: the biological fate of chemicals 20051201 |
| Antiepileptic drugs and neuroprotection: current status and future roles. | Epilepsy & behavior : E&B 20051201 |
| Dose-dependent interaction of paroxetine with risperidone in schizophrenic patients. | Journal of clinical psychopharmacology 20051201 |
| Plasma risperidone levels and clinical response in patients with first-episode psychosis. | Journal of clinical psychopharmacology 20051201 |
| Peripheral neuropathy in patients with systemic rheumatic diseases treated with leflunomide. | Annals of the rheumatic diseases 20051201 |
| Effects of zonisamide on neurotransmitter exocytosis associated with ryanodine receptors. | Epilepsy research 20051201 |
| Electron spin resonance assay of ascorbyl radical generation in mouse hippocampal slices during and after kainate-induced seizures. | Brain research. Brain research protocols 20051201 |
| Towards an epidemiology of rheumatoid arthritis outcome with respect to treatment: randomized controlled trials overestimate treatment response and effectiveness. | Rheumatology (Oxford, England) 20051201 |
| Psoriatic arthritis. | Joint, bone, spine : revue du rhumatisme 20051201 |
| Topical analgesia for chest tube removal in cardiac patients. | Journal of cardiothoracic and vascular anesthesia 20051201 |
| What is new in the therapy of ANCA-associated vasculitides? Take home messages from the 12th workshop on ANCA and systemic vasculitides. | Clinical nephrology 20051201 |
| A prospective evaluation of leflunomide therapy for cytomegalovirus disease in renal transplant recipients. | Transplantation proceedings 20051201 |
| Drug Insight: endothelin-receptor antagonists for pulmonary arterial hypertension in systemic rheumatic diseases. | Nature clinical practice. Rheumatology 20051201 |
| Activatory properties of lysophosphatidic acid on human THP-1 cells. | Inflammation 20051201 |
| More bad news about anti-inflammatory agents. | Journal of medical toxicology : official journal of the American College of Medical Toxicology 20051201 |
| Stereoselective palladium-catalyzed four-component cascade synthesis of pyrrolidinyl-, pyrazolidinyl-, and isoxazolidinyl isoquinolines. | Angewandte Chemie (International ed. in English) 20051125 |
| Increased risk of cardiovascular events with parecoxib/valdecoxib: a systematic review and meta-analysis. | The New Zealand medical journal 20051125 |
| ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis. | The Journal of biological chemistry 20051104 |
| Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors. | Journal of medicinal chemistry 20051103 |
| Characterization of fate and transport of isoxaflutole, a soil-applied corn herbicide, in surface water using a watershed model. | Journal of agricultural and food chemistry 20051102 |
| Synthesis of 4-(5-[18F]fluoromethyl-3-phenylisoxazol-4-yl)benzenesulfonamide, a new [18F]fluorinated analogue of valdecoxib, as a potential radiotracer for imaging cyclooxygenase-2 with positron emission tomography. | Bioorganic & medicinal chemistry letters 20051101 |
| Safety and efficacy of leflunomide and infliximab versus methotrexate and infliximab combination therapy in rheumatoid arthritis. | Rheumatology (Oxford, England) 20051101 |
| Subacute cutaneous lupus erythematosus precipitated by leflunomide. | Clinical and experimental dermatology 20051101 |
| Synthesis and evaluation of trimethoxyphenyl isoxazolidines as inhibitors of secretory phospholipase A2 with anti-inflammatory activity. | International journal of molecular medicine 20051101 |
| Effects of intrarenal administration of the cox-2 inhibitor parecoxib during porcine suprarenal aortic cross-clamping. | Shock (Augusta, Ga.) 20051101 |
| [Leflunomide-related severe axonal neuropathy]. | Revue neurologique 20051101 |
| Sitaxsentan: a novel endothelin-A receptor antagonist for pulmonary arterial hypertension. | Expert review of cardiovascular therapy 20051101 |
| COX-2 inhibitors and the heart: putting risk in perspective. | Advance for nurse practitioners 20051101 |
| FK778 and tacrolimus prevent the development of obliterative airway disease after heterotopic rat tracheal transplantation. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20051101 |
| The design, synthesis and screening of a muscarinic acetylcholine receptor targeted compound library. | Combinatorial chemistry & high throughput screening 20051101 |
| Cytochrome P450 3A inhibitor itraconazole affects plasma concentrations of risperidone and 9-hydroxyrisperidone in schizophrenic patients. | Clinical pharmacology and therapeutics 20051101 |
| Parecoxib versus tramadol for post-appendectomy pain. | Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20051101 |
| [Adverse events in rheumatoid arthritis patient with etanercept therapy: the appearance of osteomalacia]. | Recenti progressi in medicina 20051101 |
| Glutathione turnover in human cell lines in the presence of agents with glutathione influencing potential with and without acivicin inhibition of gamma-glutamyltranspeptidase. | Biochimica et biophysica acta 20051030 |
| Inhibition of human dendritic cell maturation and function by the novel immunosuppressant FK778. | Transplantation 20051027 |
| Zonisamide add-on for drug-resistant partial epilepsy. | The Cochrane database of systematic reviews 20051019 |
| An efficient synthesis of a dual PPAR alpha/gamma agonist and the formation of a sterically congested alpha-aryloxyisobutyric acid via a Bargellini reaction. | The Journal of organic chemistry 20051014 |
| New approach to the practical synthesis of tri- or tetrasubstituted pyrimidine derivatives: a four-component coupling reaction from a functionalized silane, two types of aromatic nitriles, and acetals. | Organic letters 20051013 |
| Heterocyclic ring scaffolds as small-molecule cholesterol absorption inhibitors. | Organic & biomolecular chemistry 20051007 |
| [Tolerance to coxibs in patients with intolerance to non-steroidal anti-inflammatory drugs (NSAIDs)]. | Deutsche medizinische Wochenschrift (1946) 20051007 |
| Synthesis, binding affinity at glutamic acid receptors, neuroprotective effects, and molecular modeling investigation of novel dihydroisoxazole amino acids. | Journal of medicinal chemistry 20051006 |
| Short-term steroid treatment increases delta GABAA receptor subunit expression in rat CA1 hippocampus: pharmacological and behavioral effects. | Neuropharmacology 20051001 |
| P-glycoprotein interaction with risperidone and 9-OH-risperidone studied in vitro, in knock-out mice and in drug-drug interaction experiments. | Human psychopharmacology 20051001 |
| Design of wide-spectrum inhibitors targeting coronavirus main proteases. | PLoS biology 20051001 |
| Toxic neuropathy. | Current opinion in neurology 20051001 |
| Spectroscopic and thermal properties of short wavelength metal (II) complexes containing alpha-isoxazolylazo-beta-diketones as co-ligands. | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20051001 |
| Subtherapeutic risperidone serum concentrations in an adolescent during hemodialysis: a pharmacological puzzle. | Therapeutic drug monitoring 20051001 |
| Valdecoxib for treatment of a single, acute, moderate to severe migraine headache. | Headache 20051001 |
| Differential effects of vigabatrin and zonisamide on the neuropeptide Y system in the hippocampus of seizure prone gerbil. | Neuropeptides 20051001 |
| Reduction of the efficacy of methotrexate by the use of folic acid: post hoc analysis from two randomized controlled studies. | Arthritis and rheumatism 20051001 |
| KKHA-761, a potent D3 receptor antagonist with high 5-HT1A receptor affinity, exhibits antipsychotic properties in animal models of schizophrenia. | Pharmacology, biochemistry, and behavior 20051001 |
| Clinical trials update from the European Society of Cardiology meeting 2005: CARE-HF extension study, ESSENTIAL, CIBIS-III, S-ICD, ISSUE-2, STRIDE-2, SOFA, IMAGINE, PREAMI, SIRIUS-II and ACTIVE. | European journal of heart failure 20051001 |
| Exploring the scope of the 29G12 antibody catalyzed 1,3-dipolar cycloaddition reaction. | The Journal of organic chemistry 20050930 |
| One-pot construction of pyrazoles and isoxazoles with palladium-catalyzed four-component coupling. | Organic letters 20050929 |
| On the two components of pyridoxal 5'-phosphate synthase from Bacillus subtilis. | The Journal of biological chemistry 20050916 |
| Integration of K+ and Cl- currents regulate steady-state and dynamic membrane potentials in cultured rat microglia. | The Journal of physiology 20050915 |
| Tetrazolyl isoxazole amino acids as ionotropic glutamate receptor antagonists: synthesis, modelling and molecular pharmacology. | Bioorganic & medicinal chemistry 20050915 |
| Effects of the active metabolite of leflunomide, A77 1726, on cytokine release and the MAPK signalling pathway in human rheumatoid arthritis synoviocytes. | Cytokine 20050907 |
| Kainate receptor-mediated synaptic transmission in the adult anterior cingulate cortex. | Journal of neurophysiology 20050901 |
| Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic alpha,beta-unsaturated esters. | Bioorganic & medicinal chemistry 20050901 |
| VPAC1 expression is regulated by FXR agonists in the human gallbladder epithelium. | Hepatology (Baltimore, Md.) 20050901 |
| Interleukin-4 and interleukin-13 enhance CCL26 production in a human keratinocyte cell line, HaCaT cells. | Clinical and experimental immunology 20050901 |
| How celecoxib could be safer, how valdecoxib might have been. | The Annals of pharmacotherapy 20050901 |
| The antinociceptive effect of local or systemic parecoxib combined with lidocaine/clonidine intravenous regional analgesia for complex regional pain syndrome type I in the arm. | Anesthesia and analgesia 20050901 |
| Population pharmacokinetics and association between A77 1726 plasma concentrations and disease activity measures following administration of leflunomide to people with rheumatoid arthritis. | British journal of clinical pharmacology 20050901 |
| Leflunomide in the treatment of rheumatoid arthritis. An analysis of predictors for treatment continuation. | British journal of clinical pharmacology 20050901 |
| Inhibition of the nuclear factor-kappaB signaling pathway by leflunomide or triptolide also inhibits the anthralin-induced inflammatory response but does not affect keratinocyte growth inhibition. | Biological & pharmaceutical bulletin 20050901 |
| Disruption of the interaction of T cells with antigen-presenting cells by the active leflunomide metabolite teriflunomide: involvement of impaired integrin activation and immunologic synapse formation. | Arthritis and rheumatism 20050901 |
| Antibacterial 4-amino-N-(5-methylisoxazol-3-yl)-N-[(4-oxo-2-phenyl-4H-1-benzopyran-6-yl)methyl]benzenesulfonamide. | Acta crystallographica. Section C, Crystal structure communications 20050901 |
| [Disease modifying antirheumatic drugs with inhibitory effect on osteoclastogenesis]. | Nihon rinsho. Japanese journal of clinical medicine 20050901 |
| Nonsteroidal anti-inflammatory drugs: confusion, controversy and dental implications. | Journal (Canadian Dental Association) 20050901 |
| [Treatment of proliferative lupus nephritis with leflunomide and steroid: a prospective multi-center controlled clinical trial]. | Zhonghua nei ke za zhi 20050901 |
| Subacute cutaneous lupus erythematosus associated with leflunomide. | Cutis 20050901 |
| In vivo evaluation of the effect of zonisamide on the hippocampal redox state during kainic acid-induced seizure status in rats. | Neurochemical research 20050901 |
| Zonisamide: review of its use in epilepsy therapy. | Drugs of today (Barcelona, Spain : 1998) 20050901 |
| Development of a novel and automated fluorescent immunoassay for the analysis of beta-lactam antibiotics. | Journal of agricultural and food chemistry 20050824 |
| Ligand selectivity for the acetylcholine binding site of the rat alpha4beta2 and alpha3beta4 nicotinic subtypes investigated by molecular docking. | Journal of medicinal chemistry 20050811 |
| Risperidone plasma levels, clinical response and side-effects. | European archives of psychiatry and clinical neuroscience 20050801 |
| Bile acid signaling through FXR induces intracellular adhesion molecule-1 expression in mouse liver and human hepatocytes. | American journal of physiology. Gastrointestinal and liver physiology 20050801 |
| Ischemic tolerance induction in organotypic hippocampal slices: role for the GABA(A) receptor? | Neuroscience letters 20050801 |
| Disease-modifying antirheumatic drug use in the elderly rheumatoid arthritis patient. | Clinics in geriatric medicine 20050801 |
| Discovery of substituted isoxazolecarbaldehydes as potent spermicides, acrosin inhibitors and mild anti-fungal agents. | Human reproduction (Oxford, England) 20050801 |
| Inflammatory bone destruction and osteoimmunology. | Journal of periodontal research 20050801 |
| Distinct patterns of expression and regulation of GABA receptors containing the delta subunit in cerebellar granule and hippocampal neurons. | Journal of neurochemistry 20050801 |
| Use of combination of leflunomide with biological agents in treatment of rheumatoid arthritis. | The Journal of rheumatology 20050801 |
| Leflunomide: new indication. In psoriatic rheumatism: too many risks, too little efficacy. | Prescrire international 20050801 |
| Endothelin antagonism in pulmonary arterial hypertension. | Seminars in respiratory and critical care medicine 20050801 |
| Centrally mediated antihyperalgesic and antiallodynic effects of zonisamide following partial nerve injury in the mouse. | Naunyn-Schmiedeberg's archives of pharmacology 20050801 |
| Population pharmacokinetics of the active metabolite of leflunomide in pediatric subjects with polyarticular course juvenile rheumatoid arthritis. | Journal of pharmacokinetics and pharmacodynamics 20050801 |
| Lithium differs from anticonvulsant mood stabilizers in prefrontal cortical and accumbal dopamine release: role of 5-HT(1A) receptor agonism. | Brain research 20050712 |
| Further action taken on COX 2 inhibitors in Europe. | BMJ (Clinical research ed.) 20050702 |
| Prostaglandin-mediated control of rat brain kynurenic acid synthesis--opposite actions by COX-1 and COX-2 isoforms. | Journal of neural transmission (Vienna, Austria : 1996) 20050701 |
| FRET-based voltage probes for confocal imaging: membrane potential oscillations throughout pancreatic islets. | American journal of physiology. Cell physiology 20050701 |
| Critical role of macrophage migration inhibitory factor activity in experimental autoimmune diabetes. | Endocrinology 20050701 |
| Use of zonisamide in pediatric patients. | Pediatric neurology 20050701 |
| Synthesis of some new steroidal [16alpha,17alpha-d]-isoxazolines. | Steroids 20050701 |
| Effects of the herbicides clomazone, quinclorac, and metsulfuron methyl on acetylcholinesterase activity in the silver catfish (Rhamdia quelen) (Heptapteridae). | Ecotoxicology and environmental safety 20050701 |
| Paternal and maternal exposure to leflunomide: pregnancy and neonatal outcome. | Annals of the rheumatic diseases 20050701 |
| Trans-dominant inhibition of RNA viral replication can slow growth of drug-resistant viruses. | Nature genetics 20050701 |
| Influence of age and gender on risperidone plasma concentrations. | Journal of psychopharmacology (Oxford, England) 20050701 |
| 2005 Dr. Gary J. Becker Young Investigator Award: periprocedural oral administration of the leflunomide analogue FK778 inhibits neointima formation in a double-injury rat model of restenosis. | Journal of vascular and interventional radiology : JVIR 20050701 |
| Effect of verapamil on pharmacokinetics and pharmacodynamics of risperidone: in vivo evidence of involvement of P-glycoprotein in risperidone disposition. | Clinical pharmacology and therapeutics 20050701 |
| Leflunomide and peripheral neuropathy: a potential interaction between uracil/tegafur and leflunomide. | Clinical pharmacology and therapeutics 20050701 |
| Pulmonary embolism in a woman taking oral contraceptives and valdecoxib. | PLoS medicine 20050701 |
| Cyclooxygenase-2 inhibitors: a new therapeutic option in the treatment of macular edema after cataract surgery. | Journal of cataract and refractive surgery 20050701 |
| An evaluation of preemptive valdecoxib therapy on discomfort caused by initial archwire placement in adult orthodontic patients. | Texas dental journal 20050701 |
| Efficacy of levetiracetam at 12 months in children classified by seizure type, cognitive status, and previous anticonvulsant drug use. | Journal of child neurology 20050701 |
| Broad-spectrum efficacy of zonisamide at 12 months in children with intractable epilepsy. | Journal of child neurology 20050701 |
| Effect of selective cyclooxygenase-2 inhibitors on heart rate in healthy young men. | The American journal of cardiology 20050615 |
| [Effective and 15 years experience. New add-on option in epilepsy therapy]]. | MMW Fortschritte der Medizin 20050609 |
| [Control of side effects. Add on therapy demonstrates good tolerance]. | MMW Fortschritte der Medizin 20050609 |
| Biaryl isoxazolinone antibacterial agents. | Bioorganic & medicinal chemistry letters 20050602 |
| Development and validation of a reversed-phase liquid chromatographic method for separation and simultaneous determination of COX-2 inhibitors in pharmaceuticals and its application to biological fluids. | Biomedical chromatography : BMC 20050601 |
| Comparative actions of clomazone on beta-carotene levels and growth in rice (Oryza sativa) and watergrasses (Echinochloa spp). | Pest management science 20050601 |
| Leflunomide-induced subacute cutaneous lupus erythematosus. | Rheumatology (Oxford, England) 20050601 |
| Laryngeal involvement in rheumatoid arthritis. | Rheumatology international 20050601 |
| Leflunomide reduces nitric oxide production in patients with active rheumatoid arthritis. | International immunopharmacology 20050601 |
| Zonisamide for West syndrome: a comparison of clinical responses among different titration rate. | Brain & development 20050601 |
| The effect of mild and moderate hepatic impairment on the pharmacokinetics of valdecoxib, a selective COX-2 inhibitor. | European journal of clinical pharmacology 20050601 |
| Effects of leflunomide on hyaluronan synthases (HAS): NF-kappa B-independent suppression of IL-1-induced HAS1 transcription by leflunomide. | Journal of immunology (Baltimore, Md. : 1950) 20050601 |
| Novel therapies for ankylosing spondylitis. | Current rheumatology reports 20050601 |
| Rescuing COX-2 inhibitors from the waste bin. | Journal of the National Cancer Institute 20050601 |
| Centrally-mediated antinociceptive actions of GABA(A) receptor agonists in the rat spared nerve injury model of neuropathic pain. | European journal of pharmacology 20050601 |
| Valdecoxib withdrawal leaves pain relief treatment gap. | Gastroenterology 20050601 |
| Leflunomide induced acute interstitial pneumonia. | The Journal of rheumatology 20050601 |
| The meaning of pain relief in a clinical trial. | The journal of pain : official journal of the American Pain Society 20050601 |
| Toward the definition of immunosuppressive regimens with antitumor activity. | Transplantation proceedings 20050601 |
| Stereochemical heterogeneity in Verongid sponge metabolites. Absolute stereochemistry of (+)-fistularin-3 and (+)-11-epi-fistularin-3 by microscale LCMS-Marfey's analysis. | Journal of natural products 20050601 |
| Cox-2 inhibitors: still no decisive action. | Prescrire international 20050601 |
| Anticonvulsant drug therapies. | Journal of psychosocial nursing and mental health services 20050601 |
| [Development of dermatomyositis in a woman with rheumatoid arthritis treated with leflunomide]. | Anales de medicina interna (Madrid, Spain : 1984) 20050601 |
| Fully automated liquid-liquid extraction for the determination of a novel insulin sensitizer in human plasma by heated nebulizer and turbo ionspray liquid chromatography-tandem mass spectrometry. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050525 |
| Two novel series of allocolchicinoids with modified seven membered B-rings: design, synthesis, inhibition of tubulin assembly and cytotoxicity. | Bioorganic & medicinal chemistry 20050516 |
| FDA ponders future of NSAIDs: Pfizer reluctantly withdraws Bextra. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20050515 |
| New restrictions on celecoxib (Celebrex) use and the withdrawal of valdecoxib (Bextra). | CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20050510 |
| Theoretical study on the excited states of HCN. | The Journal of chemical physics 20050508 |
| Effects of gabaergic drugs on reserpine-induced oral dyskinesia. | Behavioural brain research 20050507 |
| Endogenous activation of kainate receptors regulates glutamate release and network activity in the developing hippocampus. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20050504 |
| Dipeptidyl peptidase IV inhibitors derived from beta-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole. | Bioorganic & medicinal chemistry letters 20050502 |
| Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies. | Bioorganic & medicinal chemistry letters 20050502 |
| The development of new isoxazolone based inhibitors of tumor necrosis factor-alpha (TNF-alpha) production. | Bioorganic & medicinal chemistry letters 20050502 |
| Valdecoxib-associated acute generalized exanthematous pustulosis. | Burns : journal of the International Society for Burn Injuries 20050501 |
| Vioxx, Celebrex, Bextra....do we have a new target for anti-inflammatory and antipyretic therapy? | American journal of physiology. Regulatory, integrative and comparative physiology 20050501 |
| Valdecoxib is associated with improved dyspepsia-related health compared with nonspecific NSAIDs in patients with osteoarthritis or rheumatoid arthritis. | The American journal of gastroenterology 20050501 |
| Changing role of COX-2 inhibitors in the perioperative period: is parecoxib really the answer? | Anesthesia and analgesia 20050501 |
| A randomized, double-blind comparison between parecoxib sodium and propacetamol for parenteral postoperative analgesia after inguinal hernia repair in adult patients. | Anesthesia and analgesia 20050501 |
| Cyclodextrin complexes of valdecoxib: properties and anti-inflammatory activity in rat. | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20050501 |
| Predominant role of the 9-hydroxy metabolite of risperidone in elevating blood prolactin levels. | The American journal of psychiatry 20050501 |
| COX-2-selective inhibitor valdecoxib induces severe allergic skin reactions. | The Journal of allergy and clinical immunology 20050501 |
| Open-label adjunctive zonisamide in the treatment of bipolar disorders: a prospective trial. | The Journal of clinical psychiatry 20050501 |
| Effect of glutamine analogue-acivicin on tumor induced angiogenesis in Ehrlich ascites carcinoma. | Indian journal of experimental biology 20050501 |
| [Cardiovascular risks of Cox-2-antagonists. Opinion on the marketed name rofecoxib, and its market-withdrawn valdecoxib and the actual therapeutic restrictions]. | Zeitschrift fur Rheumatologie 20050501 |
| FK-778 Astellas. | Current opinion in investigational drugs (London, England : 2000) 20050501 |
| The novel immunosuppressant FK778 inhibits formation of the immunologic Synapse. | Transplantation proceedings 20050501 |
| Pfizer withdraws Bextra in South Africa. | South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 20050501 |
| Leflunomide: long-term clinical experience and new uses. | Expert opinion on pharmacotherapy 20050501 |
| [An exploratory study on in vitro effects and mechanism of leflunomide on dendritic cells of systemic lupus erythematosus]. | Zhonghua nei ke za zhi 20050501 |
| A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20050427 |
| Leflunomide or methotrexate for juvenile rheumatoid arthritis. | The New England journal of medicine 20050421 |
| Succinct synthesis of beta-amino acids via chiral isoxazolines. | Journal of the American Chemical Society 20050420 |
| Researchers plan to continue to study COX-2 inhibitors in cancer treatment and prevention. | Journal of the National Cancer Institute 20050420 |
| Calcium-stimulated adenylyl cyclases are critical modulators of neuronal ethanol sensitivity. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20050420 |
| Another popular painkiller gets the government's hook. | U.S. news & world report 20050418 |
| Pfizer is asked to suspend sales of painkiller. | BMJ (Clinical research ed.) 20050416 |
| Tandem mass spectrometric assay of succinylacetone in urine for the diagnosis of hepatorenal tyrosinemia. | Analytical biochemistry 20050415 |
| Effect of a Y265F mutant on the transamination-based cycloserine inactivation of alanine racemase. | Biochemistry 20050412 |
| Discovery of a novel series of peroxisome proliferator-activated receptor alpha/gamma dual agonists for the treatment of type 2 diabetes and dyslipidemia. | Journal of medicinal chemistry 20050407 |
| Therapeutic drug monitoring of A77 1726, the active metabolite of leflunomide: serum concentrations predict response to treatment in patients with rheumatoid arthritis. | Annals of the rheumatic diseases 20050401 |
| The influence of previous and concomitant leflunomide on the efficacy and safety of infliximab therapy in patients with rheumatoid arthritis; a longitudinal observational study. | Rheumatology (Oxford, England) 20050401 |
| Effect of repeated gaboxadol administration on night sleep and next-day performance in healthy elderly subjects. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20050401 |
| Evidence for a second binding/transport site for chloride in erythrocyte anion transporter AE1 modified at glutamate 681. | Biophysical journal 20050401 |
| Leflunomide and azathioprine combination in refractory adult-onset Still's disease. | The Annals of pharmacotherapy 20050401 |
| Novel [(biphenyloxy)propyl]isoxazole derivatives for inhibition of human rhinovirus 2 and coxsackievirus B3 replication. | The Journal of antimicrobial chemotherapy 20050401 |
| Combined discriminative stimulus effects of midazolam with other positive GABAA modulators and GABAA receptor agonists in rhesus monkeys. | Psychopharmacology 20050401 |
| Neuropathy associated with leflunomide: a case series. | Annals of the rheumatic diseases 20050401 |
| Design, synthesis, biological evaluation and molecular docking of curcumin analogues as antioxidant, cyclooxygenase inhibitory and anti-inflammatory agents. | Bioorganic & medicinal chemistry letters 20050401 |
| Enhancement in antimicrobial activity of 2-(phenyl)-3-(2-butyl-4-chloro-1H-imidazolyl)-5-butylate isoxazolidine. | Bioorganic & medicinal chemistry letters 20050401 |
| Exacerbation of carpal tunnel syndrome under treatment with valdecoxib. | Anesthesia and analgesia 20050401 |
| Exploring the GluR2 ligand-binding core in complex with the bicyclical AMPA analogue (S)-4-AHCP. | The FEBS journal 20050401 |
| Using thrombelastography to determine the efficacy of the platelet glycoprotein IIb/IIIa antagonist, roxifiban, on platelet/fibrin-mediated clot dynamics in humans. | Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20050401 |
| Lack of clinically significant pharmacokinetic interactions between zonisamide and lamotrigine at steady state in patients with epilepsy. | Therapeutic drug monitoring 20050401 |
| Physical function and health related quality of life: analysis of 2-year data from randomized, controlled studies of leflunomide, sulfasalazine, or methotrexate in patients with active rheumatoid arthritis. | The Journal of rheumatology 20050401 |
| Continuous indices of core data set measures in rheumatoid arthritis clinical trials: lower responses to placebo than seen with categorical responses with the American College of Rheumatology 20% criteria. | Arthritis and rheumatism 20050401 |
| Locomotor activity detects subunit-selective effects of agonists and decahydroisoquinoline antagonists at AMPA/kainic acid ionotropic glutamate receptors in adult rats. | Psychopharmacology 20050401 |
| Staphylococcus aureus bacteremia, Australia. | Emerging infectious diseases 20050401 |
| Synthesis and characterization of novel 6-fluoro-4-piperidinyl-1,2-benzisoxazole amides and 6-fluoro-chroman-2-carboxamides: antimicrobial studies. | Bioorganic & medicinal chemistry 20050401 |
| Chemistry and biology of dihydroisoxazole derivatives: selective inhibitors of human transglutaminase 2. | Chemistry & biology 20050401 |
| Parecoxib: renal failure. | Prescrire international 20050401 |
| Valdecoxib: cutaneous and vascular risks. | Prescrire international 20050401 |
| [New therapeutic perspectives in Sjögren syndrome: leflunomide]. | Recenti progressi in medicina 20050401 |
| Raising the safety bar--the FDA's coxib meeting. | The New England journal of medicine 20050331 |
| Discovery of 1-(3'-aminobenzisoxazol-5'-yl)-3-trifluoromethyl-N-[2-fluoro-4- [(2'-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide hydrochloride (razaxaban), a highly potent, selective, and orally bioavailable factor Xa inhibitor. | Journal of medicinal chemistry 20050324 |
| Discovery of a new series of centrally active tricyclic isoxazoles combining serotonin (5-HT) reuptake inhibition with alpha2-adrenoceptor blocking activity. | Journal of medicinal chemistry 20050324 |
| Complications of the COX-2 inhibitors parecoxib and valdecoxib after cardiac surgery. | The New England journal of medicine 20050317 |
| COX-2 inhibitors--lessons in drug safety. | The New England journal of medicine 20050317 |
| COX-2 inhibitors--a lesson in unexpected problems. | The New England journal of medicine 20050317 |
| Leflunomide for polyomavirus type BK nephropathy. | The New England journal of medicine 20050317 |
| Pulmonary abscess due to leflunomide use in rheumatoid arthritis: a case report. | Rheumatology international 20050301 |
| A liquid chromatography-mass spectrometry method for the quantification of both etoricoxib and valdecoxib in human plasma. | Biomedical chromatography : BMC 20050301 |
| Valdecoxib: assessment of cyclooxygenase-2 potency and selectivity. | The Journal of pharmacology and experimental therapeutics 20050301 |
| Regulation of carbohydrate metabolism by the farnesoid X receptor. | Endocrinology 20050301 |
| Activation of the nuclear receptor FXR induces fibrinogen expression: a new role for bile acid signaling. | Journal of lipid research 20050301 |
| Leflunomide in rheumatoid arthritis: recommendations through a process of consensus. | Rheumatology (Oxford, England) 20050301 |
| Guideline for anti-TNF-alpha therapy in psoriatic arthritis. | Rheumatology (Oxford, England) 20050301 |
| Pharmacokinetics and D2 receptor occupancy of long-acting injectable risperidone (Risperdal Consta) in patients with schizophrenia. | The international journal of neuropsychopharmacology 20050301 |
| Risperidone and breast-feeding. | Journal of psychopharmacology (Oxford, England) 20050301 |
| Prediction of response to risperidone treatment with respect to plasma concencentrations of risperidone, catecholamine metabolites, and polymorphism of cytochrome P450 2D6. | International clinical psychopharmacology 20050301 |
| Effect of zonisamide on essential tremor: a pilot crossover study in comparison with arotinolol. | Parkinsonism & related disorders 20050301 |
| [New findings on the structure-phototoxicity relationship and photostability of fluoroquinolones]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20050301 |
| Meta-analysis: upper gastrointestinal tolerability of valdecoxib, a cyclooxygenase-2-specific inhibitor, compared with nonspecific nonsteroidal anti-inflammatory drugs among patients with osteoarthritis and rheumatoid arthritis. | Alimentary pharmacology & therapeutics 20050301 |
| Successful treatment of a leg ulcer occurring in a rheumatoid arthritis patient under leflunomide therapy. | Journal of the European Academy of Dermatology and Venereology : JEADV 20050301 |
| COX-2 inhibitor induced anuric renal failure in a previously healthy young woman. | Clinical nephrology 20050301 |
| [Treatment with leflunomide in rheumatoid arthritis]. | Zeitschrift fur Rheumatologie 20050301 |
| Parecoxib versus ibuprofen. | Journal of the American Dental Association (1939) 20050301 |
| Clinical experience with zonisamide monotherapy and adjunctive therapy in children with epilepsy at a tertiary care referral center. | Journal of child neurology 20050301 |
| Possible involvement of glutamic and/or aspartic acid residue(s) and requirement of mitochondrial integrity for the protective effect of creatine against inhibition of cardiac mitochondrial respiration by methylglyoxal. | Molecular and cellular biochemistry 20050301 |
| Lessons to learn from the COX-2 saga. Yes, FDA reforms are needed. And marketing distorts how medications are used. But one moral to the story is that all drugs have risks. | Harvard health letter 20050301 |
| Coxibs: can this class of drugs survive? | Vascular health and risk management 20050301 |
| Drug safety. FDA panel urges caution on many anti-inflammatory drugs. | Science (New York, N.Y.) 20050225 |
| Vioxx may go back on sale after scraping past FDA panel. | Nature 20050224 |
| Continued use of zonisamide following development of renal calculi. | Neurology 20050222 |
| Synthesis of argentatin A derivatives as growth inhibitors of human cancer cell lines in vitro. | Bioorganic & medicinal chemistry letters 20050215 |
| Synthesis and structure-activity relationships of isoxazole carboxamides as growth hormone secretagogue receptor antagonists. | Bioorganic & medicinal chemistry letters 20050215 |
| Heterocyclic and phenyl double-bond-locked combretastatin analogues possessing potent apoptosis-inducing activity in HL60 and in MDR cell lines. | Journal of medicinal chemistry 20050210 |
| Positional ordering of reacting groups contributes significantly to the efficiency of proton transfer at an antibody active site. | Journal of the American Chemical Society 20050202 |
| Debilitating diarrhoea and weight loss due to colitis in two RA patients treated with leflunomide. | Clinical rheumatology 20050201 |
| Role of glutathione in reduction of arsenate and of gamma-glutamyltranspeptidase in disposition of arsenite in rats. | Toxicology 20050201 |
| Prostaglandins mediate the cardioprotective effects of atorvastatin against ischemia-reperfusion injury. | Cardiovascular research 20050201 |
| Selective inhibitors of GABA uptake: synthesis and molecular pharmacology of 4-N-methylamino-4,5,6,7-tetrahydrobenzo[d]isoxazol-3-ol analogues. | Bioorganic & medicinal chemistry 20050201 |
| Zonisamide monotherapy for epilepsy in children and young adults. | Pediatric neurology 20050201 |
| Serum concentrations of risperidone and 9-hydroxyrisperidone after administration of the long-acting injectable form of risperidone: evidence from a routine therapeutic drug monitoring service. | Therapeutic drug monitoring 20050201 |
| Conservation of amino acids in human rhinovirus 3C protease correlates with broad-spectrum antiviral activity of rupintrivir, a novel human rhinovirus 3C protease inhibitor. | Antimicrobial agents and chemotherapy 20050201 |
| The cyclooxygenase-2-specific inhibitor parecoxib sodium is as effective as 12 mg of morphine administered intramuscularly for treating pain after gynecologic laparotomy surgery. | Anesthesia and analgesia 20050201 |
| Post-coronary artery bypass graft liver failure: a possible association with leflunomide. | The Annals of thoracic surgery 20050201 |
| Severe bronchospasm after parenteral parecoxib: cyclooxygenase-2 inhibitors: not the answer yet. | Anesthesiology 20050201 |
| Identification of autotaxin as a neurite retraction-inducing factor of PC12 cells in cerebrospinal fluid and its possible sources. | Journal of neurochemistry 20050201 |
| Long-term open-label preliminary study of the safety and efficacy of leflunomide in patients with polyarticular-course juvenile rheumatoid arthritis. | Arthritis and rheumatism 20050201 |
| A preliminary open-label study of zonisamide treatment for bipolar depression in 10 patients. | The Journal of clinical psychiatry 20050201 |
| Mycotoxins revisited: Part II. | The Journal of emergency medicine 20050201 |
| Analysis of antiepileptic drugs in biological fluids by means of electrokinetic chromatography. | Electrophoresis 20050201 |
| Synthesis and evaluation of 2-[18F]fluoro-CP-118,954 for the in vivo mapping of acetylcholinesterase. | Nuclear medicine and biology 20050201 |
| Current concepts in nonoperative management of knee osteoarthritis. | Orthopedics 20050201 |
| [Design, synthesis and insulin-sensitizing activity of some peroxisome proliferator-activated gamma agonists]. | Yao xue xue bao = Acta pharmaceutica Sinica 20050201 |
| Rheumatoid arthritis: an update. | Delaware medical journal 20050201 |
| [Leflunomide in the treatment of rheumatoid arthritis]. | La Tunisie medicale 20050201 |
| Regulation of ultraviolet B-induced phosphorylation of histone H3 at serine 10 by Fyn kinase. | The Journal of biological chemistry 20050128 |
| Potent 4-aryl- or 4-arylalkyl-substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling. | Journal of medicinal chemistry 20050127 |
| Tolerance or accommodation: the lesson from leflunomide. | Transplantation 20050127 |
| Effects of a short course of leflunomide on T-independent B-lymphocyte xenoreactivity and on susceptibility of xenografts to acute or chronic rejection. | Transplantation 20050127 |
| Parecoxib, valdecoxib, and cardiovascular risk. | Circulation 20050125 |
| Endothelin receptor antagonists for pulmonary arterial hypertension. | The Cochrane database of systematic reviews 20050125 |
| Arthritis medicines and cardiovascular events--'house of coxibs'. | JAMA 20050119 |
| Application of QSAR analysis to organic anion transporting polypeptide 1a5 (Oatp1a5) substrates. | Bioorganic & medicinal chemistry 20050117 |
| Contribution of acetaminophen-cysteine to acetaminophen nephrotoxicity II. Possible involvement of the gamma-glutamyl cycle. | Toxicology and applied pharmacology 20050115 |
| Mechanistic study of malononitrileamide FK778 in cardiac transplantation and CMV infection in rats. | Transplantation 20050115 |
| Effect of leflunomide and cidofovir on replication of BK virus in an in vitro culture system. | Transplantation 20050115 |
| Dual angiotensin II and endothelin A receptor antagonists: synthesis of 2'-substituted N-3-isoxazolyl biphenylsulfonamides with improved potency and pharmacokinetics. | Journal of medicinal chemistry 20050113 |
| When a DMARD fails, should patients switch to sulfasalazine or add sulfasalazine to continuing leflunomide? | Annals of the rheumatic diseases 20050101 |
| Endothelin-mediated remodeling in aortas of diabetic rats. | Diabetes/metabolism research and reviews 20050101 |
| Six months open label trial of leflunomide in active ankylosing spondylitis. | Annals of the rheumatic diseases 20050101 |
| Lupus erythematosus with leflunomide: induction or reactivation? | Annals of the rheumatic diseases 20050101 |
| Selective cyclooxygenase-2 inhibition reverses microcirculatory and inflammatory sequelae of closed soft-tissue trauma in an animal model. | The Journal of bone and joint surgery. American volume 20050101 |
| [The practice guideline 'Photo(chemo)therapy and systemic therapy in severe chronic plaque-psoriasis']. | Nederlands tijdschrift voor geneeskunde 20050101 |
| Inhibition of human cytomegalovirus signaling and replication by the immunosuppressant FK778. | Antiviral research 20050101 |
| Dose-dependent safety and efficacy of zonisamide: a randomized, double-blind, placebo-controlled study in patients with refractory partial seizures. | Epilepsia 20050101 |
| Molecular modeling study of leflunomide and its active metabolite analogues. | Journal of chemical information and modeling 20050101 |
| Cyclooxygenase-2 is a target of KRASD12, which facilitates the outgrowth of murine C26 colorectal liver metastases. | Clinical cancer research : an official journal of the American Association for Cancer Research 20050101 |
| Internalized GABA-receptor subunits are transferred to an intracellular pool associated with the postsynaptic density. | The European journal of neuroscience 20050101 |
| Inhibition of human neuroblastoma cell growth by CAY10404, a highly selective Cox-2 inhibitor. | Journal of neuro-oncology 20050101 |
| Role of cyclooxygenase-2 in lipopolysaccharide-induced hyperalgesia in formalin test. | Indian journal of experimental biology 20050101 |
| Valdecoxib for treatment of primary dysmenorrhea. A randomized, double-blind comparison with placebo and naproxen. | Journal of general internal medicine 20050101 |
| Valdecoxib-induced systemic contact dermatitis confirmed by positive patch test. | Contact dermatitis 20050101 |
| Tolerance of nonsteroidal anti-inflammatory drug-sensitive patients to the highly specific cyclooxygenase 2 inhibitors rofecoxib and valdecoxib. | Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20050101 |
| Enhancement of dissolution rate of valdecoxib using solid dispersions with polyethylene glycol 4000. | Drug development and industrial pharmacy 20050101 |
| Effects of Na+-Ca2+ exchanger activity on the alpha-amino-3-hydroxy-5-methyl-4-isoxazolone-propionate-induced Ca2+ influx in cerebellar Purkinje neurons. | Neuroscience 20050101 |
| Isoxazole ionotropic glutamate neurotransmitters. | Current medicinal chemistry 20050101 |
| [New immunodepressant drugs for the prevention and control of kidney transplant rejection]. | Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia 20050101 |
| Effectiveness and safety profile of leflunomide in rheumatoid arthritis: actual practice compared with clinical trials. | Clinical and experimental rheumatology 20050101 |
| [Guidelines for RA therapies]. | Nihon rinsho. Japanese journal of clinical medicine 20050101 |
| [Disease modifying anti-rheumatic drugs (DMARDs): an overview]. | Nihon rinsho. Japanese journal of clinical medicine 20050101 |
| [Leflunomide for therapy of rheumatoid arthritis]. | Nihon rinsho. Japanese journal of clinical medicine 20050101 |
| [Adverse effects of DMARDs in treatment of rheumatoid arthritis]. | Nihon rinsho. Japanese journal of clinical medicine 20050101 |
| Sentence ordered in drug counterfeiting case. | FDA consumer 20050101 |
| FK778 controls acute rejection after rat liver allotransplantation showing positive interaction with FK506. | Transplantation proceedings 20050101 |
| Zonisamide: a review of its use in the management of partial seizures in epilepsy. | CNS drugs 20050101 |
| Zonisamide for absence seizures. | Epilepsy research 20050101 |
| Modelling cost effectiveness and cost utility of sequential DMARD therapy including leflunomide in rheumatoid arthritis in Germany: I. Selected DMARDs and patient-related costs. | PharmacoEconomics 20050101 |
| Modelling cost effectiveness and cost utility of sequential DMARD therapy including leflunomide for rheumatoid arthritis in Germany: II. The contribution of leflunomide to efficiency. | PharmacoEconomics 20050101 |
| Valdecoxib for the management of chronic and acute pain. | Expert review of neurotherapeutics 20050101 |
| Zonisamide: physician and patient experiences. | Epilepsy research 20050101 |
| Lack of pharmacokinetic interactions between steady-state zonisamide and valproic acid in patients with epilepsy. | Clinical pharmacokinetics 20050101 |
| The active metabolite of leflunomide, A77 1726, interferes with dendritic cell function. | Arthritis research & therapy 20050101 |
| [Involvement of L-arginine-nitric oxide-cyclic GMP pathway in the peripheral antinociceptive effect induced by parecoxib]. | Cirugia y cirujanos 20050101 |
| Is there a rationale to using leflunomide in early rheumatoid arthritis? | Clinical and experimental rheumatology 20050101 |
| Zonisamide in the treatment of painful diabetic neuropathy: a randomized, double-blind, placebo-controlled pilot study. | Pain medicine (Malden, Mass.) 20050101 |
| COX-2 selective inhibitors in the treatment of arthritis: a rheumatologist perspective. | Current topics in medicinal chemistry 20050101 |
| [Evaluation of rheumatoid arthritis activity in clinical practice]. | Terapevticheskii arkhiv 20050101 |
| [Experience in long-term therapy of active rheumatoid arthritis with leflunomide]. | Terapevticheskii arkhiv 20050101 |
| [Effective treatment of systemic sclerosis with leflunomide]. | Terapevticheskii arkhiv 20050101 |
| Regulatory paternalism in the market for drugs: lessons from Vioxx and Celebrex. | Yale journal of health policy, law, and ethics 20050101 |
| Nonprotein thiols and disulfides in rat epididymal spermatozoa and epididymal fluid: role of gamma-glutamyl-transpeptidase in sperm maturation. | Journal of andrology 20050101 |
| Evaluation of the true precocious puberty rats induced by neonatal administration of Danazol: therapeutic effects of nourishing 'Yin'-Removing 'Fire' Chinese herb mixture. | Reproductive biology and endocrinology : RB&E 20050101 |
| In vivo metabolism for the hydroxylation of FK778 to the metabolite M3 in humans studied by enantioselective liquid chromatography/tandem mass spectrometry. | Rapid communications in mass spectrometry : RCM 20050101 |
| FDA announces changes affecting the marketing of non-steroidal anti-inflammatory drugs. | FDA consumer 20050101 |
| Successful treatment of SAPHO syndrome with leflunomide. Report of two cases. | Clinical and experimental rheumatology 20050101 |
| Increased extracellular glutamate evoked by 1-methyl-4-phenylpyridinium [MPP(+)] in the rat striatum is not essential for dopaminergic neurotoxicity and is not derived from released glutathione. | Neurotoxicity research 20050101 |
| Comparison of reporting of Stevens-Johnson syndrome and toxic epidermal necrolysis in association with selective COX-2 inhibitors. | Drug safety 20050101 |
| Efficacy of malononitrilamide FK778 in a preclinical model of small bowel transplantation. | Transplantation proceedings 20050101 |
| Assessment of an LC-MS method for plasma quantification of the new immunosuppressant FK778 through comparison with HPLC-UV. | Transplantation proceedings 20050101 |
| Zonisamide at clinically relevant concentrations inhibits field EPSP but not presynaptic fiber volley in rat frontal cortex. | Epilepsy research 20050101 |
| Administration of leflunomide to a patient with rheumatoid arthritis on haemodialysis. | Scandinavian journal of rheumatology 20050101 |
| Chemical and biochemical transformations of 5-ethoxycarbonyl-5-phenyl-2-isoxazolines. | Farmaco (Societa chimica italiana : 1989) 20050101 |
| [Leflunomide: assessing teratogenic risk during the first trimester of pregnancy]. | Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20050101 |
| [Cyclooxygenase-2 inhibitors and the ethics of research]. | Medicina 20050101 |
| [Use of low molecular weight heparin (Clexane) together with selective COX-2 inhibitor (Dynastat--once or twice per day)]. | Akusherstvo i ginekologiia 20050101 |
| Severe hepatotoxicity in a rheumatoid arthritis patient switched from leflunomide to methotrexate. | MedGenMed : Medscape general medicine 20050101 |
| Laryngospasm and bronchospasm following parecoxib injections. | Journal of pain & palliative care pharmacotherapy 20050101 |
| COX-2 inhibitors and heart. | Indian heart journal 20050101 |
| Disease modifying treatment for feline rheumatoid arthritis. | Veterinary and comparative orthopaedics and traumatology : V.C.O.T 20050101 |
| Concern about one drug or entire class of drugs. | Reumatizam 20050101 |
| COX-2 selective inhibitors and heart health. | Postgraduate medicine 20050101 |
| FK778, a synthetic malononitrilamide. | Yonsei medical journal 20041231 |
| Isoxazolyl-serine-based agonists of peroxisome proliferator-activated receptor: design, synthesis, and effects on cardiomyocyte differentiation. | Journal of the American Chemical Society 20041229 |
| Charged residues at the 2' position of human GABAC rho 1 receptors invert ion selectivity and influence open state probability. | The Journal of biological chemistry 20041224 |
| Cardiovascular toxicity of valdecoxib. | The New England journal of medicine 20041223 |
| Isoxazole-3-hydroxamic acid derivatives as peptide deformylase inhibitors and potential antibacterial agents. | Bioorganic & medicinal chemistry letters 20041220 |
| Effects and mechanisms of FR167653, a dual inhibitor of interleukin-1 and tumor necrosis factor, on adjuvant arthritis in rats. | International immunopharmacology 20041215 |
| Synthesis and microbial inhibition study of novel 5-imidazolyl substituted isoxazolidines. | Bioorganic & medicinal chemistry 20041215 |
| FK778 and FK506 combination therapy to control acute rejection after rat liver allotransplantation. | Transplantation 20041215 |
| Modeling the 5-year cost effectiveness of treatment strategies including tumor necrosis factor-blocking agents and leflunomide for treating rheumatoid arthritis in the Netherlands. | Arthritis and rheumatism 20041215 |
| Effect of soil properties on the degradation of isoxaflutole and the sorption-desorption of isoxaflutole and its diketonitrile degradate. | Journal of agricultural and food chemistry 20041215 |
| Use of leflunomide in an allogeneic bone marrow transplant recipient with refractory cytomegalovirus infection. | Bone marrow transplantation 20041201 |
| Overview of Japanese experience-controlled and uncontrolled trials. | Seizure 20041201 |
| Zonisamide monotherapy with once-daily dosing in children with cryptogenic localization-related epilepsies: clinical effects and pharmacokinetic studies. | Seizure 20041201 |
| Review of zonisamide development in Japan. | Seizure 20041201 |
| Effects of zonisamide monotherapy in children with epilepsy. | Seizure 20041201 |
| Clinical efficacy of zonisamide in childhood epilepsy after long-term treatment: a postmarketing, multi-institutional survey. | Seizure 20041201 |
| Efficacy of zonisamide: our experience. | Seizure 20041201 |
| Zonisamide: chemistry, mechanism of action, and pharmacokinetics. | Seizure 20041201 |
| Safety of zonisamide therapy: prospective follow-up survey. | Seizure 20041201 |
| Zonisamide overview of the United States experience. | Seizure 20041201 |
| Review of United States and European clinical trials of zonisamide in the treatment of refractory partial-onset seizures. | Seizure 20041201 |
| Zonisamide clinical trials: European experience. | Seizure 20041201 |
| Sulfone COX-2 inhibitors increase susceptibility of human LDL and plasma to oxidative modification: comparison to sulfonamide COX-2 inhibitors and NSAIDs. | Atherosclerosis 20041201 |
| Leflunomide inhibits transendothelial migration of peripheral blood mononuclear cells. | Annals of the rheumatic diseases 20041201 |
| Reaction between parecoxib and vecuronium. | Anaesthesia 20041201 |
| Prevention of cholesterol gallstone disease by FXR agonists in a mouse model. | Nature medicine 20041201 |
| Comparison of valdecoxib and an oxycodone-acetaminophen combination for acute musculoskeletal pain in the emergency department: a randomized controlled trial. | Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 20041201 |
| Influence of coadministered antiepileptic drugs on serum phenobarbital concentrations in epileptic patients: quantitative analysis based on a suitable transforming factor. | Biological & pharmaceutical bulletin 20041201 |
| Effects of zonisamide on the electroencephalogram of a patient with juvenile myoclonic epilepsy. | Epilepsy & behavior : E&B 20041201 |
| Serious dermatologic reaction associated with valdecoxib: report of two cases. | Journal of the American Academy of Dermatology 20041201 |
| Induction of antinuclear antibodies in patients with rheumatoid arthritis treated with infliximab and leflunomide. | Arthritis and rheumatism 20041201 |
| Novel immunosuppressants. | Pediatric transplantation 20041201 |
| The broadening use of leflunomide in clinical practice. | Hospital medicine (London, England : 1998) 20041201 |
| Efficacy and tolerability of zonisamide in juvenile myoclonic epilepsy. | Epileptic disorders : international epilepsy journal with videotape 20041201 |
| [The specific cox-2 inhibitor valdecoxib provides effective analgesia after inguinal hernia surgery]. | Revista espanola de anestesiologia y reanimacion 20041201 |
| A cautionary note when using zonisamide in youths: a case report of association with toxic epidermal necrolysis. | The Journal of clinical psychiatry 20041201 |
| Could Bextra increase heart risks too? | Health news (Waltham, Mass.) 20041201 |
| Interstitial lung disease associated with leflunomide. | Internal medicine (Tokyo, Japan) 20041201 |
| Rheumatoid arthritis complicated with acute interstitial pneumonia induced by leflunomide as an adverse reaction. | Internal medicine (Tokyo, Japan) 20041201 |
| Functional identification and monitoring of individual alpha and beta cells in cultured mouse islets of Langerhans. | Acta diabetologica 20041201 |
| [Review of analgesics]. | Revue de l'infirmiere 20041201 |
| Effects of the antiepileptics phenytoin and zonisamide on dentin formation and bone mineral density of the mandible in growing rats. | Methods and findings in experimental and clinical pharmacology 20041201 |
| The brain entry of risperidone and 9-hydroxyrisperidone is greatly limited by P-glycoprotein. | The international journal of neuropsychopharmacology 20041201 |
| The 'alphabet' of rheumatoid arthritis treatment. | Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses 20041201 |
| [Respiratory complications of new treatments for rheumatoid arthritis]. | Revue des maladies respiratoires 20041201 |
| A painkiller is pulled from the market. So what do you do now? | Heart advisor 20041201 |
| Effect of zonisamide on the pharmacokinetics and pharmacodynamics of a combination ethinyl estradiol-norethindrone oral contraceptive in healthy women. | Clinical therapeutics 20041201 |
| Search for new lead structures for low-molecular-weight immune response modifiers. | Acta poloniae pharmaceutica 20041201 |
| Structure and immunological activity of disubstituted thiosemicarbazide isoxazole derivative. | Acta poloniae pharmaceutica 20041201 |
| New synthetic equivalent of nitromalonaldehyde treatable in organic media. | The Journal of organic chemistry 20041126 |
| An orally bioavailable, functionally selective inverse agonist at the benzodiazepine site of GABAA alpha5 receptors with cognition enhancing properties. | Journal of medicinal chemistry 20041118 |
| Expedited SAR study of an mGluR5 antagonists: generation of a focused library using a solution-phase Suzuki coupling methodology. | Bioorganic & medicinal chemistry letters 20041115 |
| Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors. | Bioorganic & medicinal chemistry letters 20041115 |
| Assessing the role of GLUK5 and GLUK6 at hippocampal mossy fiber synapses. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20041110 |
| Patient preferences for treatment of rheumatoid arthritis. | Annals of the rheumatic diseases 20041101 |
| Modulation of effector cell functions in experimental autoimmune encephalomyelitis by leflunomide--mechanisms independent of pyrimidine depletion. | Journal of leukocyte biology 20041101 |
| NK95806, a newly synthesized microtubule-disrupting agent that suppresses collagen-induced arthritis in mice. | International immunopharmacology 20041101 |
| CPEC induces erythroid differentiation of human myeloid leukemia K562 cells through CTP depletion and p38 MAP kinase. | Leukemia 20041101 |
| Leflunomide protects from T-cell-mediated liver injury in mice through inhibition of nuclear factor kappaB. | Hepatology (Baltimore, Md.) 20041101 |
| High glutathione turnover in human cell lines revealed by acivicin inhibition of gamma-glutamyltranspeptidase and the effects of thiol-reactive metals during acivicin inhibition. | Clinica chimica acta; international journal of clinical chemistry 20041101 |
| Lack of a clinically significant effect of zonisamide on phenytoin steady-state pharmacokinetics in patients with epilepsy. | Journal of clinical pharmacology 20041101 |
| Sitaxsentan, a selective endothelin-A receptor antagonist for the treatment of pulmonary arterial hypertension. | Expert opinion on investigational drugs 20041101 |
| Do guidelines for the prescribing and monitoring of leflunomide need to be modified? | Rheumatology (Oxford, England) 20041101 |
| Pulmonary hypertension in a patient with rheumatoid arthritis treated with leflunomide. | Rheumatology (Oxford, England) 20041101 |
| Carbamazepine pharmacokinetics are not affected by zonisamide: in vitro mechanistic study and in vivo clinical study in epileptic patients. | Epilepsy research 20041101 |
| Zonisamide and associated oligohidrosis and hyperthermia. | Epilepsy research 20041101 |
| Postmarketing surveillance for drug safety. | Clinical pharmacology and therapeutics 20041101 |
| Damage control in rheumatoid arthritis. Hard-hitting, early treatment is crucial to curbing joint destruction. | Postgraduate medicine 20041101 |
| [The active metabolite of leflunomide A771726 inhibits proliferation and collagen synthesis of hepatic stellate cell]. | Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20041101 |
| The analgesic efficacy of intramuscular parecoxib sodium in postoperative dental pain. | Journal of the American Dental Association (1939) 20041101 |
| Zonisamide: newer antiepileptic agent with multiple mechanisms of action. | Expert review of neurotherapeutics 20041101 |
| Pfizer criticised over delay in admitting drug's problems. | BMJ (Clinical research ed.) 20041023 |
| Coxibs and cardiovascular disease. | The New England journal of medicine 20041021 |
| Novel isoxazole carboxamides as growth hormone secretagogue receptor (GHS-R) antagonists. | Bioorganic & medicinal chemistry letters 20041018 |
| GABA(A) agonists and partial agonists: THIP (Gaboxadol) as a non-opioid analgesic and a novel type of hypnotic. | Biochemical pharmacology 20041015 |
| Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. | Journal of medicinal chemistry 20041007 |
| Presurgical intravenous parecoxib sodium and follow-up oral valdecoxib for pain management after laparoscopic cholecystectomy surgery reduces opioid requirements and opioid-related adverse effects. | Acta anaesthesiologica Scandinavica 20041001 |
| Efficacy and safety of valdecoxib for treatment of osteoarthritis and rheumatoid arthritis: systematic review of randomised controlled trials. | Pain 20041001 |
| Acute treatment of bipolar depression with adjunctive zonisamide: a retrospective chart review. | Bipolar disorders 20041001 |
| Regulation of CYP3A4 by the bile acid receptor FXR: evidence for functional binding sites in the CYP3A4 gene. | Pharmacogenetics 20041001 |
| Role of the betaine/GABA transporter (BGT-1/GAT2) for the control of epilepsy. | European journal of pharmacology 20041001 |
| Adverse events with disease modifying antirheumatic drugs (DMARD): a cohort study of leflunomide compared with other DMARD. | The Journal of rheumatology 20041001 |
| Vasculitis associated with the use of leflunomide. | The Journal of rheumatology 20041001 |
| Life-threatening hypertriglyceridemia during leflunomide therapy in a patient with rheumatoid arthritis. | Arthritis and rheumatism 20041001 |
| Sustained symptomatic, functional, and hemodynamic benefit with the selective endothelin-A receptor antagonist, sitaxsentan, in patients with pulmonary arterial hypertension: a 1-year follow-up study. | Chest 20041001 |
| Leflunomide in psoriasis and psoriatic arthritis: a preliminary study. | Archives of dermatology 20041001 |
| A clinical trial demonstrates the analgesic activity of intravenous parecoxib sodium compared with ketorolac or morphine after gynecologic surgery with laparotomy. | American journal of obstetrics and gynecology 20041001 |
| Anticonvulsant drugs in primary headaches prophylaxis. | Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20041001 |
| Antimetabolites in the treatment of arthritis: current status of the use of antimetabolites. | Nucleosides, nucleotides & nucleic acids 20041001 |
| Dihydroorotate dehydrogenase mRNA and protein expression analysis in normal and drug-resistant cells. | Nucleosides, nucleotides & nucleic acids 20041001 |
| Comparison of anti-arthritic properties of leflunomide with methotrexate and FK506: effect on T cell activation-induced inflammatory cytokine production in vitro and rat adjuvant-induced arthritis. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20041001 |
| The cyclooxygenase-2 inhibitor celecoxib is a potent inhibitor of human carbonic anhydrase II. | Inflammation 20041001 |
| Novel synthesis of 3,4-diarylisoxazole analogues of valdecoxib: reversal cyclooxygenase-2 selectivity by sulfonamide group removal. | Journal of medicinal chemistry 20040923 |
| A rapid and simple determination of A77 1726 in human serum by high-performance liquid chromatography and its application for optimization of leflunomide therapy. | Journal of pharmaceutical and biomedical analysis 20040921 |
| Discovery of isoxazolinone antibacterial agents. Nitrogen as a replacement for the stereogenic center found in oxazolidinone antibacterials. | Bioorganic & medicinal chemistry letters 20040920 |
| Catalysis by hydrophobically modified poly(propylenimine) dendrimers having quaternary ammonium and tertiary amine functionality. | Langmuir : the ACS journal of surfaces and colloids 20040914 |
| Stability study of amorphous valdecoxib. | International journal of pharmaceutics 20040910 |
| [When to begin rheumatism treatment? Initial combination therapy helps fastest]. | MMW Fortschritte der Medizin 20040909 |
| [Three joints swollen, blood sedimentation increased. Methotrexate to be given immediately?]. | MMW Fortschritte der Medizin 20040909 |
| Differential effects of leflunomide and methotrexate on cytokine production in rheumatoid arthritis. | Annals of the rheumatic diseases 20040901 |
| Altered pharmacology of synaptic and extrasynaptic GABAA receptors on CA1 hippocampal neurons is consistent with subunit changes in a model of alcohol withdrawal and dependence. | The Journal of pharmacology and experimental therapeutics 20040901 |
| Characterisation of the effects of ATPA, a GLU(K5) kainate receptor agonist, on GABAergic synaptic transmission in the CA1 region of rat hippocampal slices. | Neuropharmacology 20040901 |
| In vitro and in vivo characterization of a novel naphthylamide ATP-sensitive K+ channel opener, A-151892. | British journal of pharmacology 20040901 |
| Suppressive effect of leflunomide metabolite (A77 1726) on metalloproteinase production in IL-1beta stimulated rheumatoid synovial fibroblasts. | Clinical and experimental immunology 20040901 |
| Patients' global evaluation of analgesia and safety of injected parecoxib for postoperative pain: a quantitative systematic review. | Anesthesia and analgesia 20040901 |
| Reduced incidence of upper gastrointestinal ulcer complications with the COX-2 selective inhibitor, valdecoxib. | Alimentary pharmacology & therapeutics 20040901 |
| 'Fast-track' drug approvals hit speed bumps in Japan. | Nature medicine 20040901 |
| A high-performance liquid chromatographic-atmospheric pressure chemical ionization-tandem mass spectrometric method for determination of risperidone and 9-hydroxyrisperidone in human plasma. | Journal of analytical toxicology 20040901 |
| [Psoriasis arthritis--long-term treatment of two patients with leflunomide]. | Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 20040901 |
| Physiological ligands ADP and Pi modulate the degree of intrinsic coupling in the ATP synthase of the photosynthetic bacterium Rhodobacter capsulatus. | Biochemistry 20040831 |
| Antagonism by NOS inhibition of the behavioral effects of benzodiazepine and GABAA receptor agonists in the mouse elevated plus-maze. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040801 |
| Parecoxib sodium demonstrates gastrointestinal safety comparable to placebo in healthy subjects. | Journal of clinical gastroenterology 20040801 |
| Synthesis, theoretical and structural analyses, and enantiopharmacology of 3-carboxy homologs of AMPA. | Chirality 20040801 |
| Synthesis and biological evaluation of novel T-type Ca2+ channel blockers. | Bioorganic & medicinal chemistry 20040801 |
| Inducible-costimulator-mediated suppression of human immunodeficiency virus type 1 replication in CD4(+) T lymphocytes. | Virology 20040801 |
| Leflunomide in active rheumatoid arthritis: a prospective study in daily practice. | British journal of clinical pharmacology 20040801 |
| Plasma risperidone concentrations during combined treatment with sertraline. | Therapeutic drug monitoring 20040801 |
| Dialyzability of the antiepileptic drug zonisamide in patients undergoing hemodialysis. | Epilepsia 20040801 |
| First and second generations of COX-2 selective inhibitors. | Mini reviews in medicinal chemistry 20040801 |
| Combination leflunomide and methotrexate (MTX) therapy for patients with active rheumatoid arthritis failing MTX monotherapy: open-label extension of a randomized, double-blind, placebo controlled trial. | The Journal of rheumatology 20040801 |
| Effects of valdecoxib in the treatment of chronic low back pain: results of a randomized, placebo-controlled trial. | Clinical therapeutics 20040801 |
| In vitro effects of risperidone and 9-hydroxy-risperidone on human platelet function, plasma coagulation, and fibrinolysis. | Clinical therapeutics 20040801 |
| Novel delta2-isoxazolines as group II phospholipase A2 inhibitors. | Bioorganic & medicinal chemistry letters 20040716 |
| Newer disease-modifying antirheumatic drugs and the risk of serious hepatic adverse events in patients with rheumatoid arthritis. | The American journal of medicine 20040715 |
| FK778: a powerful immunosuppressive, but will it really be good for you? | Transplantation 20040715 |
| The effects of FK778 in combination with tacrolimus and steroids: a phase II multicenter study in renal transplant patients. | Transplantation 20040715 |
| FK778 attenuates lymphocyte-endothelium interaction after cardiac transplantation: in vivo and in vitro studies. | Transplantation 20040715 |
| Accuracy of splitting unscored valdecoxib tablets. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20040715 |
| Streptococcal toxic shock syndrome and sepsis manifesting in a patient with chronic rheumatoid arthritis. | Dermatology online journal 20040715 |
| Stereochemically rich pentaketides from bis(isoxazolines): a general strategy for efficient polyketide synthesis. | Organic letters 20040708 |
| Nonspecific medium effects versus specific group positioning in the antibody and albumin catalysis of the base-promoted ring-opening reactions of benzisoxazoles. | Journal of the American Chemical Society 20040707 |
| Inhibition of gamma-glutamyl transpeptidase activity decreases intracellular cysteine levels in cervical carcinoma. | Cancer chemotherapy and pharmacology 20040701 |
| Inhibitory effect of leflunomide on hepatic fibrosis induced by CCl4 in rats. | Acta pharmacologica Sinica 20040701 |
| Peripheral neuropathy in patients on leflunomide. | Rheumatology (Oxford, England) 20040701 |
| Synthesis and biological evaluation of 3-heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and analogues as subtype-selective inverse agonists for the GABA(A)alpha5 benzodiazepine binding site. | Journal of medicinal chemistry 20040701 |
| Extraarticular rheumatoid arthritis and drug-induced syndromes: understanding the role of tumor necrosis factor inhibitors. | The Journal of rheumatology 20040701 |
| Reversal of the inhibition of photosynthesis by herbicides affecting hydroxyphenylpyruvate dioxygenase by plastoquinone and tocopheryl derivatives in Chlamydomonas reinhardtii. | Pest management science 20040701 |
| The analgesic effects that underlie patient satisfaction with treatment. | Pain 20040701 |
| Therapeutic interchange involving replacement of rofecoxib or celecoxib with valdecoxib. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20040701 |
| Gaboxadol. Lundbeck/Merck. | Current opinion in investigational drugs (London, England : 2000) 20040701 |
| One step regioselective synthesis of 5-aminoisoxazoles from nitrile oxides and alpha-cyanoenamines. | Molecules (Basel, Switzerland) 20040630 |
| The synthesis and antimicrobial evaluation of a new series of isoxazolinyl oxazolidinones. | Bioorganic & medicinal chemistry letters 20040621 |
| In vitro SAR of (5-(2H)-isoxazolonyl) ureas, potent inhibitors of hormone-sensitive lipase. | Bioorganic & medicinal chemistry letters 20040621 |
| The Kemp elimination in membrane mimetic reaction media. Probing catalytic properties of cationic vesicles formed from a double-tailed amphiphile and linear long-tailed alcohols or alkyl pyranosides. | Organic & biomolecular chemistry 20040621 |
| [Methotrexate combined with leflunomide or hydroxychloroquine in the treatment of rheumatoid arteritis]. | Zhonghua yi xue za zhi 20040617 |
| Decarboxylation of 6-nitrobenzisoxazole-3-carboxylate as kinetic probe for piperazinium-based cationic micelles. | Journal of colloid and interface science 20040615 |
| Unprecedented in situ oxidative ring cleavage of isoxazolidines: diastereoselective transformation of nitronic acids and derivatives into 3-hydroxymethyl 4-nitro tetrahydrofurans and pyrrolidines. | Organic letters 20040610 |
| Synthesis of 3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazoles, displaying combined 5-HT uptake inhibiting and alpha2-adrenoceptor antagonistic activities. Part 2: Further exploration on the cinnamyl moiety. | Bioorganic & medicinal chemistry letters 20040607 |
| [Diagnosis and therapy of rheumatoid arthritis]. | Deutsche medizinische Wochenschrift (1946) 20040604 |
| Deletion of the fyn-kinase gene alters sensitivity to GABAergic drugs: dependence on beta2/beta3 GABAA receptor subunits. | The Journal of pharmacology and experimental therapeutics 20040601 |
| Pediatric phase I trial and pharmacokinetic study of the platelet-derived growth factor (PDGF) receptor pathway inhibitor SU101. | Cancer chemotherapy and pharmacology 20040601 |
| Efficacy and safety of leflunomide 10 mg versus 20 mg once daily in patients with active rheumatoid arthritis: multinational double-blind, randomized trial. | Rheumatology (Oxford, England) 20040601 |
| Zonisamide monotherapy in a multi-group clinic. | Seizure 20040601 |
| Early analgesic effects of parecoxib versus ketorolac following laparoscopic sterilization: a randomized controlled trial. | British journal of anaesthesia 20040601 |
| Long term evaluation of radiographic disease progression in a subset of patients with rheumatoid arthritis treated with leflunomide beyond 2 years. | Annals of the rheumatic diseases 20040601 |
| Dose escalation of leflunomide (LEF) to 40 mg once daily in patients with rheumatoid arthritis and insufficient response to standard dose LEF. | Annals of the rheumatic diseases 20040601 |
| Randomized, controlled clinical trial of zonisamide as adjunctive treatment for refractory partial seizures. | Epilepsia 20040601 |
| Leflunomide in active rheumatoid arthritis: a prospective study in daily practice. | British journal of clinical pharmacology 20040601 |
| Systematic review of the analgesic efficacy and tolerability of COX-2 inhibitors in post-operative pain control. | Journal of clinical pharmacy and therapeutics 20040601 |
| Preoperative parenteral parecoxib and follow-up oral valdecoxib reduce length of stay and improve quality of patient recovery after laparoscopic cholecystectomy surgery. | Anesthesia and analgesia 20040601 |
| Leflunomide attenuates hepatocyte injury by inhibiting Kupffer cells. | World journal of gastroenterology 20040601 |
| Synthesis and evaluation of 5,7-dihydro-3-[2-[1-(4-[18F]-fluorobenzyl)-4-piperidinyl]ethyl]-6H-pyrrolo[3,2-f]-1,2-benzisoxazol-6-one for in vivo mapping of acetylcholinesterase. | Nuclear medicine communications 20040601 |
| Induction of cyclooxygenase-1 in cultured synovial cells isolated from rheumatoid arthritis patients. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20040601 |
| Novel dopamine releasing response of an anti-convulsant agent with possible anti-Parkinson's activity. | Journal of neural transmission (Vienna, Austria : 1996) 20040601 |
| The efficacy of leflunomide monotherapy in rheumatoid arthritis: towards the goals of disease modifying antirheumatic drug therapy. | The Journal of rheumatology. Supplement 20040601 |
| Leflunomide: a manageable safety profile. | The Journal of rheumatology. Supplement 20040601 |
| Lefunomide in combination therapy. | The Journal of rheumatology. Supplement 20040601 |
| What I would like to know about leflunomide. | The Journal of rheumatology 20040601 |
| Synthesis, antiprotozoal and cytotoxic activities of new N-(3,4-dimethyl-5-isoxazolyl)-1,2-naphthoquinone-4-amino derivatives. | Farmaco (Societa chimica italiana : 1989) 20040601 |
| Peripheral neuropathy in patients treated with leflunomide. | Clinical pharmacology and therapeutics 20040601 |
| Efficacy and safety of leflunomide in the treatment of psoriatic arthritis and psoriasis: a multinational, double-blind, randomized, placebo-controlled clinical trial. | Arthritis and rheumatism 20040601 |
| Safety of 25- and 50-mg capsules in the initiation of zonisamide therapy in patients with epilepsy: an uncontrolled, open-label study. | Current medical research and opinion 20040601 |
| Leflunomide as a novel treatment option in severe atopic dermatitis. | The British journal of dermatology 20040601 |
| Parecoxib: new preparation. A NSAID for postoperative pain: no proven advantage. | Prescrire international 20040601 |
| QTc interval, CYP2D6 and CYP2C9 genotypes and risperidone plasma concentrations. | Journal of psychopharmacology (Oxford, England) 20040601 |
| New pharmacotherapies for pediatric seizures. | Pediatric annals 20040601 |
| The farnesoid X receptor induces very low density lipoprotein receptor gene expression. | FEBS letters 20040521 |
| New drugs for rheumatoid arthritis. | The New England journal of medicine 20040520 |
| Concentration-dependent effects of endogenous S-nitrosoglutathione on gene regulation by specificity proteins Sp3 and Sp1. | The Biochemical journal 20040515 |
| Leflunomide therapy for cytomegalovirus disease in renal allograft recepients. | Transplantation 20040515 |
| New drugs to improve transplant outcomes. | Transplantation 20040515 |
| Safety of newer antiepileptic drugs. | JAMA 20040505 |
| Parecoxib for parenteral analgesia in postsurgical patients. | The Annals of pharmacotherapy 20040501 |
| Effects of various factors on steady-state plasma concentrations of risperidone and 9-hydroxyrisperidone: lack of impact of MDR-1 genotypes. | British journal of clinical pharmacology 20040501 |
| Differential inhibition of fracture healing by non-selective and cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs. | Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20040501 |
| Efficacy and tolerability of the new antiepileptic drugs, I: Treatment of new-onset epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society. | Epilepsia 20040501 |
| Efficacy and tolerability of the new antiepileptic drugs, II: Treatment of refractory epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society. | Epilepsia 20040501 |
| A systematic review of COX-2 inhibitors compared with traditional NSAIDs, or different COX-2 inhibitors for post-operative pain. | Acta anaesthesiologica Scandinavica 20040501 |
| Parecoxib sodium, an injectable COX-2-specific inhibitor, does not affect unfractionated heparin-regulated blood coagulation parameters. | Journal of clinical pharmacology 20040501 |
| Chronic overdose of leflunomide inducing interstitial nephritis. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20040501 |
| Subacute cutaneous lupus erythematosus associated with leflunomide. | Clinical and experimental dermatology 20040501 |
| Valdecoxib versus rofecoxib in acute postsurgical pain: results of a randomized controlled trial. | Journal of pain and symptom management 20040501 |
| Glycoprotein IIb/IIIa inhibitors increase COAT-platelet production in vitro. | The Journal of laboratory and clinical medicine 20040501 |
| The plasma membrane of microaerophilic protists: oxidative and nitrosative stress. | Microbiology (Reading, England) 20040501 |
| Utilization of zonisamide in patients with chronic pain or epilepsy refractory to other treatments: a retrospective, open label, uncontrolled study in a VA hospital. | Current medical research and opinion 20040501 |
| Leflunomide in the treatment of psoriasis: results of a phase II open trial. | The British journal of dermatology 20040501 |
| Safety overview of new disease-modifying antirheumatic drugs. | Rheumatic diseases clinics of North America 20040501 |
| Overview of radiologic efficacy of new treatments. | Rheumatic diseases clinics of North America 20040501 |
| Leflunomide. | Rheumatic diseases clinics of North America 20040501 |
| Leflunomide-induced aseptic meningitis. | Joint, bone, spine : revue du rhumatisme 20040501 |
| Role of parecoxib in pre-emptive analgesia: comparison of the efficacy and safety of pre- and postoperative parecoxib in patients undergoing general surgery. | Journal of the Indian Medical Association 20040501 |
| Efficacy and tolerability of the new antiepileptic drugs II: treatment of refractory epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society. | Neurology 20040427 |
| Pharmacological profile of parecoxib: a novel, potent injectable selective cyclooxygenase-2 inhibitor. | European journal of pharmacology 20040426 |
| Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1. | The Journal of biological chemistry 20040423 |
| Investigation of conjugate addition/intramolecular nitrone dipolar cycloadditions and their use in the synthesis of dendrobatid alkaloid precursors. | Organic & biomolecular chemistry 20040421 |
| Combined effects of cyclooxygenase-1 and cyclooxygenase-2 selective inhibitors on intestinal tumorigenesis in adenomatous polyposis coli gene knockout mice. | International journal of cancer 20040420 |
| Catalytic asymmetric synthesis of glutamate analogues. | Organic letters 20040415 |
| The safety and efficacy of leflunomide in combination with infliximab in rheumatoid arthritis. | Arthritis and rheumatism 20040415 |
| Interstitial lung disease and disease modifying anti-rheumatic drugs. | Lancet (London, England) 20040410 |
| Discovery, modeling, and human pharmacokinetics of N-(2-acetyl-4,6-dimethylphenyl)-3-(3,4-dimethylisoxazol-5-ylsulfamoyl)thiophene-2-carboxamide (TBC3711), a second generation, ETA selective, and orally bioavailable endothelin antagonist. | Journal of medicinal chemistry 20040408 |
| Quantitation of Valdecoxib in human plasma by high-performance liquid chromatography with ultraviolet absorbance detection using liquid-liquid extraction. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040405 |
| Correlation between scores on Continuous Performance Test and plasma concentration for schizophrenic patients on risperidone. | Psychiatry and clinical neurosciences 20040401 |
| Acivicin-induced alterations in renal and hepatic glutathione concentrations and in gamma-glutamyltransferase activities. | Biochemical pharmacology 20040401 |
| Synergistic drug combinations against the in vitro replication of Coxsackie B1 virus. | Antiviral research 20040401 |
| 3D QSAR studies on T-type calcium channel blockers using CoMFA and CoMSIA. | Bioorganic & medicinal chemistry 20040401 |
| Successful use of zonisamide for central poststroke pain. | The journal of pain : official journal of the American Pain Society 20040401 |
| [Valdecoxib (Bextra)]. | Revue medicale de Liege 20040401 |
| Leflunomide in the treatment of rheumatoid arthritis. | Clinical therapeutics 20040401 |
| Inactivation of human liver arginase by Woodward's reagent K: evidence for reaction with His141. | The protein journal 20040401 |
| A 771726, the active metabolite of leflunomide, inhibits TNF-alpha and IL-1 from Kupffer cells. | Inflammation 20040401 |
| The membrane potential of the intraerythrocytic malaria parasite Plasmodium falciparum. | The Journal of biological chemistry 20040319 |
| Evaluation of the binding of the tricyclic isoxazole photoaffinity label LY475776 to multidrug resistance associated protein 1 (MRP1) orthologs and several ATP- binding cassette (ABC) drug transporters. | Biochemical pharmacology 20040315 |
| Design, synthesis, and biological evaluation of new 8-heterocyclic xanthine derivatives as highly potent and selective human A2B adenosine receptor antagonists. | Journal of medicinal chemistry 20040311 |
| The complete characterization of a rhodium Lewis acid-dipolarophile complex as an intermediate for the enantioselective catalytic 1,3-dipolar cycloaddition of C,N-diphenylnitrone to methacrolein. | Journal of the American Chemical Society 20040310 |
| [Collagen diseases and rheumatic diseases]. | Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20040310 |
| Solid-phase synthesis of 5-isoxazol-4-yl-[1,2,4]oxadiazoles. | The Journal of organic chemistry 20040305 |
| Effects of brassinazole, an inhibitor of brassinosteroid biosynthesis, on light- and dark-grown Chlorella vulgaris. | Planta 20040301 |
| Estradiol and testosterone modulate the anesthetic action of the GABA-A agonist THIP, but not of the neurosteroid 3alpha,5beta-pregnanolone in the rat. | Psychopharmacology 20040301 |
| Constitutive expression and involvement of cyclooxygenase-2 in human megakaryocytopoiesis. | Arteriosclerosis, thrombosis, and vascular biology 20040301 |
| Histological and immunological characteristics of, and the effect of immunosuppressive treatment on, xenograft vasculopathy. | Xenotransplantation 20040301 |
| Maintenance of remission with leflunomide in Wegener's granulomatosis. | Rheumatology (Oxford, England) 20040301 |
| Pharmacological activation of plasma-membrane KATP channels reduces reoxygenation-induced Ca(2+) overload in cardiac myocytes via modulation of the diastolic membrane potential. | British journal of pharmacology 20040301 |
| The antirheumatic drug leflunomide inhibits osteoclastogenesis by interfering with receptor activator of NF-kappa B ligand-stimulated induction of nuclear factor of activated T cells c1. | Arthritis and rheumatism 20040301 |
| Additive effects of leflunomide and tacrolimus in prevention of islet xenograft rejection. | Scandinavian journal of immunology 20040301 |
| [Clinical guidelines for treatment of epilepsy in children]. | No to hattatsu = Brain and development 20040301 |
| Collision-induced dissociation of valdecoxib metabolites: a novel rearrangement involving an isoxazole ring. | Journal of mass spectrometry : JMS 20040301 |
| The cyclooxygenase isozyme inhibitors parecoxib and paracetamol reduce central hyperalgesia in humans. | Pain 20040301 |
| Leflunomide for chronic sarcoidosis. | Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG 20040301 |
| Parecoxib: a shift in pain management? | Expert review of neurotherapeutics 20040301 |
| The interaction between FK778 and tacrolimus in the prevention of rat cardiac allograft rejection is dose dependent. | Transplantation 20040227 |
| Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 1: Discovery and SAR study of 4-pyrazolylpiperidine side chains. | Bioorganic & medicinal chemistry letters 20040223 |
| Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA1. | The Journal of biological chemistry 20040220 |
| Changes in biophysical parameters of plasma membranes influence cisplatin resistance of sensitive and resistant epidermal carcinoma cells. | Experimental cell research 20040215 |
| Selective or nonselective endothelin receptor blockade in pulmonary arterial hypertension. | American journal of respiratory and critical care medicine 20040215 |
| Weekly leflunomide as monotherapy for recent-onset rheumatoid arthritis. | Arthritis and rheumatism 20040215 |
| Gamma-glutamyltranspeptidase stimulates receptor activator of nuclear factor-kappaB ligand expression independent of its enzymatic activity and serves as a pathological bone-resorbing factor. | The Journal of biological chemistry 20040213 |
| Quantification of risperidone and 9-hydroxyrisperidone in plasma and saliva from adult and pediatric patients by liquid chromatography-mass spectrometry. | Journal of chromatography. A 20040213 |
| Japan deaths spark concerns over arthritis drug. | Lancet (London, England) 20040207 |
| The new antiepileptic drugs: scientific review. | JAMA 20040204 |
| Zonisamide-induced depression and mania in patients with epilepsy. | Journal of clinical psychopharmacology 20040201 |
| The endothelin system in pulmonary arterial hypertension. | Cardiovascular research 20040201 |
| Leflunomide (Arava)-induced cystoid macular oedema. | Rheumatology (Oxford, England) 20040201 |
| Effective treatment of laparoscopic cholecystectomy pain with intravenous followed by oral COX-2 specific inhibitor. | Anesthesia and analgesia 20040201 |
| Transfer of risperidone and 9-hydroxyrisperidone into human milk. | The Annals of pharmacotherapy 20040201 |
| Glutamate regulates Oct-2 DNA-binding activity through alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptors in cultured chick Bergmann glia cells. | Journal of neurochemistry 20040201 |
| Rheumatological creativity and leflunomide. | The Journal of rheumatology 20040201 |
| Rheumatoid arthritis treatment with weekly leflunomide: an open-label study. | The Journal of rheumatology 20040201 |
| Gamma-glutamyl transpeptidase inhibition suppresses milk protein synthesis in isolated ovine mammary cells. | Journal of dairy science 20040201 |
| Reporting of clinical trials of analgesia. | The Journal of thoracic and cardiovascular surgery 20040201 |
| Structure/activity investigations of 5-substituted 3-methylisoxazole[5, 4-d]1, 2, 3-triazin-4-one derivatives. | Archiv der Pharmazie 20040201 |
| [Contribution of leflunomide to the cost effectiveness of sequential DMARD therapy of rheumatoid arthritis in Germany]. | Zeitschrift fur Rheumatologie 20040201 |
| [Development and/or increase of rheumatoid nodules in RA patients following leflunomide therapy]. | Zeitschrift fur Rheumatologie 20040201 |
| [High throughput screening method of potassium channel regulators]. | Yao xue xue bao = Acta pharmaceutica Sinica 20040201 |
| Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition. | Journal of medicinal chemistry 20040129 |
| Zonisamide treatment for symptomatic infantile spasms. | Neurology 20040127 |
| A stereochemical anomaly: the cyclised (R)-AMPA analogue (R)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-5-carboxylic acid [(R)-5-HPCA] resembles (S)-AMPA at glutamate receptors. | Organic & biomolecular chemistry 20040121 |
| Synthesis, monoamine transporter binding properties, and behavioral pharmacology of a series of 3beta-(substituted phenyl)-2beta-(3'-substituted isoxazol-5-yl)tropanes. | Journal of medicinal chemistry 20040115 |
| Homoepiboxidines: further potent agonists for nicotinic receptors. | Bioorganic & medicinal chemistry 20040102 |
| One-pot synthesis of functionalized 4,5-dihydroisoxazole derivatives via nitrile oxides and biological evaluation with plant cells. | Bioorganic & medicinal chemistry 20040102 |
| Synthesis and pharmacological assessment of derivatives of isoxazolo[4,5-d]pyrimidine. | Bioorganic & medicinal chemistry 20040102 |
| Changes in rectal temperature and ECoG spectral power of sensorimotor cortex elicited in conscious rabbits by i.c.v. injection of GABA, GABA(A) and GABA(B) agonists and antagonists. | British journal of pharmacology 20040101 |
| Inhibitors of CTP biosynthesis potentiate the anti-human immunodeficiency virus type 1 activity of 3TC in activated peripheral blood mononuclear cells. | Antiviral research 20040101 |
| Anticonvulsant and antiepileptogenic effects of GABAA receptor ligands in pentylenetetrazole-kindled mice. | Progress in neuro-psychopharmacology & biological psychiatry 20040101 |
| Anti-hyperalgesic activity of the cox-2 inhibitor lumiracoxib in a model of bone cancer pain in the rat. | Pain 20040101 |
| Differential effects of selective COX-2 inhibitors on cell cycle regulation and proliferation of glioblastoma cell lines. | Cancer biology & therapy 20040101 |
| Leflunomide and anti-glomerular basement membrane glomerulonephritis: comment on the letter by Bruyn et al. | Arthritis and rheumatism 20040101 |
| Zonisamide in the treatment of binge-eating disorder: an open-label, prospective trial. | The Journal of clinical psychiatry 20040101 |
| Synthesis and COX-2 inhibitory properties of N-phenyl- and N-benzyl-substituted amides of 2-(4-methylsulfonylphenyl)cyclopent-1-ene-1-carboxylic acid and of their pyrazole, thiophene and isoxazole analogs. | Farmaco (Societa chimica italiana : 1989) 20040101 |
| Novel therapeutic effects of the anti-convulsant, zonisamide, on Parkinson's disease. | Current pharmaceutical design 20040101 |
| Leflunomide-induced acute hepatitis. | Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20040101 |
| [Drug safety. Notes about surveillance]. | Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20040101 |
| Effect of selective inhibition of cyclooxygenase-2 on lipopolysaccharide-induced hyperalgesia. | Inflammopharmacology 20040101 |
| Prevalence of antimicrobial resistance in bacteria isolated from central nervous system specimens as reported by U.S. hospital laboratories from 2000 to 2002. | Annals of clinical microbiology and antimicrobials 20040101 |
| Leflunomide for the treatment of rheumatoid arthritis in clinical practice: incidence and severity of hepatotoxicity. | Drug safety 20040101 |
| Photodistributed lichenoid drug eruption with rhabdomyolysis occurring during leflunomide therapy. | Dermatology (Basel, Switzerland) 20040101 |
| An unusual overdose of leflunomide in a patient with rheumatoid arthritis. | The Annals of pharmacotherapy 20040101 |
| A mechanistic perspective on the specificity and extent of COX-2 inhibition in pregnancy. | Drug safety 20040101 |
| The active metabolite of leflunomide, A77 1726, increases the production of IL-1 receptor antagonist in human synovial fibroblasts and articular chondrocytes. | Arthritis research & therapy 20040101 |
| Risperidone treatment of children with autistic disorder: effectiveness, tolerability, and pharmacokinetic implications. | Journal of child and adolescent psychopharmacology 20040101 |
| Safety of leflunomide plus infliximab combination therapy in rheumatoid arthritis. | Clinical and experimental rheumatology 20040101 |
| New immunosuppressive strategies in renal transplant recipients. | Journal of nephrology 20040101 |
| Analgesic efficacy of preoperative parecoxib sodium in an orthopedic pain model. | Journal of the American Podiatric Medical Association 20040101 |
| Valdecoxib: a review of its use in the management of osteoarthritis, rheumatoid arthritis, dysmenorrhoea and acute pain. | Drugs 20040101 |
| Leflunomide-associated pancytopenia with or without methotrexate. | The Annals of pharmacotherapy 20040101 |
| The active metabolite of leflunomide, A771726, inhibits both the generation of and the bone-resorbing activity of osteoclasts by acting directly on cells of the osteoclast lineage. | Journal of bone and mineral metabolism 20040101 |
| [Changes in indices of inflammatory activity in patients with rheumatoid arthritis during early stages of basic therapy with leflunomide]. | Terapevticheskii arkhiv 20040101 |
| Leflunomide: a novel disease modifying anti-rheumatic drug. | Journal of postgraduate medicine 20040101 |
| Zonisamide therapy for refractory idiopathic epilepsy in dogs. | Journal of the American Animal Hospital Association 20040101 |
| Newer anticonvulsants in the treatment of bipolar disorder. | The Journal of clinical psychiatry 20040101 |
| Antiepileptic drugs in migraine prophylaxis: state of the art. | La Clinica terapeutica 20040101 |
| Effects of the cyclooxygenase-2 specific inhibitor valdecoxib versus nonsteroidal antiinflammatory agents and placebo on cardiovascular thrombotic events in patients with arthritis. | American journal of therapeutics 20040101 |
| Pharmacologic treatment of the catastrophic epilepsies. | Epilepsia 20040101 |
| [Treatment of Wegener's granulomatosis]. | Reumatismo 20040101 |
| [Updated treatment of primary pulmonary hypertension -- the role of endothelin receptor antagonists]. | Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20040101 |
| Psoriatic arthritis. | Dermatologic therapy 20040101 |
| Double-blind, randomized, placebo-controlled pilot study of leflunomide in systemic lupus erythematosus. | Lupus 20040101 |
| Cooperation in signal transduction of extracellular guanosine 5' triphosphate and nerve growth factor in neuronal differentiation of PC12 cells. | Neuroscience 20040101 |
| Surveillance of antimicrobial resistance at a tertiary hospital in Tanzania. | BMC public health 20040101 |
| Parecoxib impairs early tendon repair but improves later remodeling. | The American journal of sports medicine 20040101 |
| Clomazone dissipation, adsorption and translocation in four paddy topsoils. | Journal of environmental sciences (China) 20040101 |
| [Current EULAR data on valdecoxib. New study results of gastrointestinal safety and 'cost effectiveness']. | Krankenpflege Journal 20040101 |
| Human umbilical cord blood cells differentiate into muscle in sjl muscular dystrophy mice. | Stem cells (Dayton, Ohio) 20040101 |
| Interrelationship of macropores and subsurface drainage for conservative tracer and pesticide transport. | Journal of environmental quality 20040101 |
| New hope for patients with pulmonary hypertension: endothelin receptor antagonists: update for the clinical nurse specialist. | Clinical nurse specialist CNS 20040101 |
| Evidence-based evaluation of immunomodulatory therapy for the cutaneous manifestations of lupus. | Advances in dermatology 20040101 |
| Benefit/risk of leflunomide in rheumatoid arthritis. | Clinical and experimental rheumatology 20040101 |
| [Some new drugs: valdecoxib (Betra), voriconazole (Vfend), ezetimide (Ezetrol), teriparatide (Forsteo)]. | Journal de pharmacie de Belgique 20040101 |
| [Basic therapy of rheumatoid arthritis with leflunomide (review)]. | Terapevticheskii arkhiv 20040101 |
| Open-label zonisamide for refractory migraine. | Clinical neuropharmacology 20040101 |
| Degradation of RPA 202248 [U-14C-phenyl]alpha(-(cyclopropylcarbonyl)-2-(methylsulfonyl)-beta-oxo-4-(trifluromethyl)benzenepropanenitrile), the primary degradation product of isoxaflutole, in an outdoor aquatic microcosm system. | Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 20040101 |
| Induction of autoantibodies in refractory rheumatoid arthritis treated by infliximab. | Clinical and experimental rheumatology 20040101 |
| Effectiveness and safety of infliximab combined with leflunomide in chronic polyarthritis. | Clinical and experimental rheumatology 20040101 |
| Degradation of isoxaflutole (balance) herbicide by hypochlorite in tap water. | Journal of agricultural and food chemistry 20031231 |
| 2-arylureidobenzoic acids: selective noncompetitive antagonists for the homomeric kainate receptor subtype GluR5. | Journal of medicinal chemistry 20031218 |
| Rotarod studies in the rat of the GABAA receptor agonist gaboxadol: lack of ethanol potentiation and benzodiazepine cross-tolerance. | European journal of pharmacology 20031215 |
| Leflunomide use during the first 33 months after food and drug administration approval: experience with a national cohort of 3,325 patients. | Arthritis and rheumatism 20031215 |
| Immunosuppression with FK778 and mycophenolate mofetil in a rat cardiac transplantation model. | Transplantation 20031215 |
| Pyrazole and isoxazole derivatives as new, potent, and selective 20-hydroxy-5,8,11,14-eicosatetraenoic acid synthase inhibitors. | Journal of medicinal chemistry 20031204 |
| 1,2-benzisoxazole phosphorodiamidates as novel anticancer prodrugs requiring bioreductive activation. | Journal of medicinal chemistry 20031204 |
| Novel N6-substituted adenosine 5'-N-methyluronamides with high selectivity for human adenosine A3 receptors reduce ischemic myocardial injury. | American journal of physiology. Heart and circulatory physiology 20031201 |
| T cell aggregation induced through CD43: intracellular signals and inhibition by the immunomodulatory drug leflunomide. | Journal of leukocyte biology 20031201 |
| Pharmacological actions of a novel and selective dopamine D3 receptor antagonist, KCH-1110. | Pharmacological research 20031201 |
| The role of cyclooxygenase selective inhibitors in the gastrointestinal tract. | Current gastroenterology reports 20031201 |
| Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis. | The Journal of clinical investigation 20031201 |
| Novel therapies in pediatric rheumatic diseases. | Current opinion in pediatrics 20031201 |
| Intra- and interindividual variations in steady-state plasma concentrations of risperidone and 9-hydroxyrisperidone in schizophrenic patients treated chronically with various doses of risperidone. | Therapeutic drug monitoring 20031201 |
| Influence of coadministered antiepileptic drugs on serum zonisamide concentrations in epileptic patients: quantitative analysis based on suitable transforming factor. | Biological & pharmaceutical bulletin 20031201 |
| [Clinical pharmacology of the selective COX-2 inhibitors]. | Der Orthopade 20031201 |
| Efficacy and safety of leflunomide and predisposing factors for treatment response in patients with active rheumatoid arthritis: RELIEF 6-month data. | The Journal of rheumatology 20031201 |
| Evaluation of the efficacy, safety and tolerability of valdecoxib gel (1%) in adult patients with painful inflammatory joint disease. | Journal of the Indian Medical Association 20031201 |
| Use of selenium-bound resin for the solid-phase synthesis of substituted isoxazolyl-substituted (E)-olefins. | Organic letters 20031127 |
| Synthesis and in vitro activity of novel isoxazolyl tetrahydropyridinyl oxazolidinone antibacterial agents. | Bioorganic & medicinal chemistry letters 20031117 |
| Aza-THIP and related analogues of THIP as GABA C antagonists. | Bioorganic & medicinal chemistry 20031117 |
| Endothelin receptor blockers in cardiovascular disease. | Circulation 20031104 |
| The burden of acute postoperative pain and the potential role of the COX-2-specific inhibitors. | Rheumatology (Oxford, England) 20031101 |
| Economic evaluation of oral valdecoxib versus diclofenac in the treatment of patients with rheumatoid arthritis in a randomized clinical trial. | Rheumatology (Oxford, England) 20031101 |
| Bile secretory function after warm hepatic ischemia-reperfusion injury in the rat. | Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20031101 |
| Transport of Cl- across the plasma membrane during pollen grain germination in tobacco. | Biochemistry. Biokhimiia 20031101 |
| Light and clomazone effects on tobacco (Nicotiana tabacum) callus and leaf discs. | Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 20031101 |
| Exfoliative dermatitis induced by leflunomide therapy. | The Journal of dermatology 20031101 |
| Synthesis of cyclic and acyclic beta-amino acids via chelation-controlled 1,3-dipolar cycloaddition. | The Journal of organic chemistry 20031031 |
| [Pain therapy in rheumatism. After 65 years of age coxibs are the best choice]. | MMW Fortschritte der Medizin 20031016 |
| Solution-phase synthesis of novel delta2-isoxazoline libraries via 1,3-dipolar cycloaddition and their antifungal properties. | Bioorganic & medicinal chemistry 20031015 |
| [Emergence of new therapeutic agents for collagen diseases and some of the problems]. | Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20031010 |
| Valdecoxib is as effective as diclofenac in the management of rheumatoid arthritis with a lower incidence of gastroduodenal ulcers: results of a 26-week trial. | Rheumatology (Oxford, England) 20031001 |
| Survival and effectiveness of leflunomide compared with methotrexate and sulfasalazine in rheumatoid arthritis: a matched observational study. | Annals of the rheumatic diseases 20031001 |
| In vitro metabolism studies on the isoxazole ring scission in the anti-inflammatory agent lefluonomide to its active alpha-cyanoenol metabolite A771726: mechanistic similarities with the cytochrome P450-catalyzed dehydration of aldoximes. | Drug metabolism and disposition: the biological fate of chemicals 20031001 |
| Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors. | Molecular pharmacology 20031001 |
| Enantioselective synthesis of alpha,beta-disubstituted-beta-amino acids. | Journal of the American Chemical Society 20031001 |
| Effects of rofecoxib, celecoxib, and parecoxib on anti-IgE-induced histamine release from human skin mast cells and basophils. | Allergy 20031001 |
| Correlation between clinical response to treatment and radiographic progression: comment on the article by Strand and Sharp. | Arthritis and rheumatism 20031001 |
| COX-2/VEGF-dependent facilitation of tumor-associated angiogenesis and tumor growth in vivo. | Laboratory investigation; a journal of technical methods and pathology 20031001 |
| Acivicin induce filamentous growth of Saccharomyces cerevisiae. | Bioscience, biotechnology, and biochemistry 20031001 |
| Effect of antiepileptic drug monotherapy on crystalluria in children and young adults. | Journal of neurology 20031001 |
| Stability of reconstituted parecoxib for injection with commonly used diluents. | Journal of clinical pharmacy and therapeutics 20031001 |
| 4-Hydroxyphenylpyruvate dioxygenase as a drug discovery target. | Drug news & perspectives 20031001 |
| Evidence for inhibitory effect of the agonist gaboxadol at human alpha 1 beta 2 gamma 2S GABAA receptors. | European journal of pharmacology 20030930 |
| Preparation of 3-acetoacetylaminobenzo[b]furan derivatives with cysteinyl leukotriene receptor 2 antagonistic activity. | Organic & biomolecular chemistry 20030921 |
| Development and validation of an automated SPE-LC-MS/MS assay for valdecoxib and its hydroxylated metabolite in human plasma. | Journal of pharmaceutical and biomedical analysis 20030915 |
| Human rhinovirus capsid dynamics is controlled by canyon flexibility. | Virology 20030915 |
| One- and two-step spin-crossover behavior of [Fe(II)(isoxazole)(6)](2+) and the structure and magnetic properties of triangular [Fe(III)(3)O(OAc)(6)(isoxazole)(3)][ClO(4)]. | Inorganic chemistry 20030908 |
| Differential effects of iloperidone, clozapine, and haloperidol on working memory of rats in the delayed non-matching-to-position paradigm. | Psychopharmacology 20030901 |
| Is the recommended dose of leflunomide the best regimen to treat rheumatoid arthritis patients? | Rheumatology (Oxford, England) 20030901 |
| Selective cyclo-oxygenase-2 inhibition with parecoxib acutely impairs endothelium-dependent vasodilatation in patients with essential hypertension. | Journal of hypertension 20030901 |
| [New drugs and treatment strategies for rheumatoid arthritis]. | Recenti progressi in medicina 20030901 |
| Single doses of parecoxib sodium intravenously are as effective as ketorolac in reducing pain after oral surgery. | Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20030901 |
| Valdecoxib, a COX-2-specific inhibitor, does not affect cardiac repolarization. | Journal of clinical pharmacology 20030901 |
| Is leflunomide as safe and effective in the treatment of rheumatoid arthritis as other DMARDs? | American family physician 20030901 |
| Effects of leflunomide on human cartilage. | Farmaco (Societa chimica italiana : 1989) 20030901 |
| Development of resistance to disoxaril in Coxsackie B1 virus-infected newborn mice. | Antiviral research 20030901 |
| Extrasynaptic GABA(A) channels activated by THIP are modulated by diazepam in CA1 pyramidal neurons in the rat brain hippocampal slice. | Molecular and cellular neurosciences 20030901 |
| Prolylisoxazoles: potent inhibitors of prolyloligopeptidase with antitrypanosomal activity. | Bioorganic & medicinal chemistry letters 20030901 |
| Oxcarbazepine, topiramate, zonisamide, and levetiracetam: potential use in neuropathic pain. | The American journal of geriatric pharmacotherapy 20030901 |
| Effect of zonisamide on molecular regulation of glutamate and GABA transporter proteins during epileptogenesis in rats with hippocampal seizures. | Brain research. Molecular brain research 20030819 |
| Anti-androgens with full antagonistic activity toward human prostate tumor LNCaP cells with mutated androgen receptor. | Bioorganic & medicinal chemistry letters 20030818 |
| Synthesis of 3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazoles, displaying combined 5-HT uptake inhibiting and alpha(2)-adrenoceptor antagonistic activities: a novel series of potential antidepressants. | Bioorganic & medicinal chemistry letters 20030818 |
| Leflunomide analogue FK778 is vasculoprotective independent of its immunosuppressive effect: potential applications for restenosis and chronic rejection. | Transplantation 20030815 |
| Enantioselective syntheses and cytotoxicity of N,O-nucleosides. | Journal of medicinal chemistry 20030814 |
| Human kininogen gene is transactivated by the farnesoid X receptor. | The Journal of biological chemistry 20030801 |
| Substituent effect on the reductive N-dearylation of 3-(indol-1-yl)-1,2-benzisoxazoles by rat liver microsomes. | Drug metabolism and disposition: the biological fate of chemicals 20030801 |
| Leflunomide in Crohn's disease--the open-label case series and the Texas sharpshooter. | Journal of clinical gastroenterology 20030801 |
| Leflunomide treatment of Crohn's disease patients intolerant to standard immunomodulator therapy. | Journal of clinical gastroenterology 20030801 |
| Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression. | Gastroenterology 20030801 |
| Toward a definition and method of assessment of treatment failure and treatment effectiveness: the case of leflunomide versus methotrexate. | The Journal of rheumatology 20030801 |
| Leflunomide, a new disease-modifying drug for treating active rheumatoid arthritis in methotrexate-controlled phase II clinical trial. | Chinese medical journal 20030801 |
| [Effect of zonisamide on resting tremor resistant to antiparkinsonian medication]. | No to shinkei = Brain and nerve 20030801 |
| S-nitrosylation signaling in cell biology. | Molecular interventions 20030801 |
| Anti-HIV-1 activity of leflunomide: a comparison with mycophenolic acid and hydroxyurea. | AIDS (London, England) 20030725 |
| [Tolerable pain therapy in rheumatism saves long-term costs. Despite this most COX-2 candidates receive conventional NSAID therapy]. | MMW Fortschritte der Medizin 20030724 |
| Functional characterization of the novel antipsychotic iloperidone at human D2, D3, alpha 2C, 5-HT6, and 5-HT1A receptors. | Life sciences 20030718 |
| An investigation of the Lewis acid mediated 1,3-dipolar cycloaddition between N-benzyl-C-(2-pyridyl)nitrone and allylic alcohol. Direct entry to isoxazolidinyl C-nucleosides. | Organic & biomolecular chemistry 20030707 |
| Synthesis and anticonvulsant activity of novel bicyclic acidic amino acids. | Journal of medicinal chemistry 20030703 |
| Differential effects of pulsatile versus steady flow on coronary endothelial membrane potential. | American journal of physiology. Heart and circulatory physiology 20030701 |
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