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287383-59-9 | 1H-Benz[de]isoquinoline-2(3H)-hexanamide, N-hydroxy-1,3-dioxo-
CAS No: 287383-59-9 Catalog No: AG002WB4 MDL No:MFCD00386477
Product Description
Catalog Number:
AG002WB4
Chemical Name:
1H-Benz[de]isoquinoline-2(3H)-hexanamide, N-hydroxy-1,3-dioxo-
CAS Number:
287383-59-9
Molecular Formula:
C18H18N2O4
Molecular Weight:
326.3465
MDL Number:
MFCD00386477
IUPAC Name:
6-(1,3-dioxobenzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide
InChI:
InChI=1S/C18H18N2O4/c21-15(19-24)10-2-1-3-11-20-17(22)13-8-4-6-12-7-5-9-14(16(12)13)18(20)23/h4-9,24H,1-3,10-11H2,(H,19,21)
InChI Key:
JTDYUFSDZATMKU-UHFFFAOYSA-N
SMILES:
ONC(=O)CCCCCn1c(=O)c2cccc3c2c(c1=O)ccc3
Properties
Complexity:
477
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
326.127g/mol
Formal Charge:
0
Heavy Atom Count:
24
Hydrogen Bond Acceptor Count:
4
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
326.352g/mol
Monoisotopic Mass:
326.127g/mol
Rotatable Bond Count:
6
Topological Polar Surface Area:
86.7A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2
Literature
| Title | Journal |
|---|---|
| Scriptaid effects on breast cancer cell lines. | Journal of cellular physiology 20121001 |
| Histone deacetylase inhibition improves activation of ribosomal RNA genes and embryonic nucleolar reprogramming in cloned mouse embryos. | Biology of reproduction 20111101 |
| AMP-activated protein kinase regulates beta-catenin transcription via histone deacetylase 5. | The Journal of biological chemistry 20110506 |
| Enrichment of Nur77 mediated by retinoic acid receptor β leads to apoptosis of human hepatocellular carcinoma cells induced by fenretinide and histone deacetylase inhibitors. | Hepatology (Baltimore, Md.) 20110301 |
| Treatment with a histone deacetylase inhibitor after nuclear transfer improves the preimplantation development of cloned bovine embryos. | The Journal of reproduction and development 20110201 |
| Identification of fetal hemoglobin-inducing agents using the human leukemia KU812 cell line. | Experimental biology and medicine (Maywood, N.J.) 20101101 |
| HDAC inhibitor, scriptaid, induces glioma cell apoptosis through JNK activation and inhibits telomerase activity. | Journal of cellular and molecular medicine 20100801 |
| Histone deacetylase inhibitor Scriptaid reactivates latent HIV-1 promoter by inducing histone modification in in vitro latency cell lines. | International journal of molecular medicine 20100801 |
| Histone deacetylase inhibitors de-repress tyrosine hydroxylase expression in the olfactory bulb and rostral migratory stream. | Biochemical and biophysical research communications 20100319 |
| Chemical phylogenetics of histone deacetylases. | Nature chemical biology 20100301 |
| Histone deacetylase inhibitors improve in vitro and in vivo developmental competence of somatic cell nuclear transfer porcine embryos. | Cellular reprogramming 20100201 |
| Scriptaid, a novel histone deacetylase inhibitor, enhances the response of human tumor cells to radiation. | International journal of molecular medicine 20100101 |
| Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis. | Nature chemical biology 20100101 |
| Histone deacetylase inhibitor uses p21(Cip1) to maintain anergy in CD4+ T cells. | International immunopharmacology 20091001 |
| Significant improvement in cloning efficiency of an inbred miniature pig by histone deacetylase inhibitor treatment after somatic cell nuclear transfer. | Biology of reproduction 20090901 |
| The histone deacetylase inhibitor scriptaid enhances nascent mRNA production and rescues full-term development in cloned inbred mice. | Reproduction (Cambridge, England) 20090801 |
| Anti-inflammatory effect of Trichostatin-A on murine bone marrow-derived macrophages. | Archives of pharmacal research 20090401 |
| Histone deacetylase inhibitor scriptaid induces cell cycle arrest and epigenetic change in colon cancer cells. | International journal of oncology 20081001 |
| Acetylation of histone H3 and adrenergic-regulated gene transcription in rat pinealocytes. | Endocrinology 20071001 |
| Scriptaid and suberoylanilide hydroxamic acid are histone deacetylase inhibitors with potent anti-Toxoplasma gondii activity in vitro. | The Journal of parasitology 20070601 |
| Suppression of class I and II histone deacetylases blunts pressure-overload cardiac hypertrophy. | Circulation 20060606 |
| A novel histone deacetylase inhibitor, Scriptaid, induces growth inhibition, cell cycle arrest and apoptosis in human endometrial cancer and ovarian cancer cells. | International journal of molecular medicine 20060201 |
| Fetal hemoglobin induction by the histone deacetylase inhibitor, scriptaid. | Cellular and molecular biology (Noisy-le-Grand, France) 20050905 |
| Induction of human gamma globin gene expression by histone deacetylase inhibitors. | Blood 20040115 |
| (2-amino-phenyl)-amides of omega-substituted alkanoic acids as new histone deacetylase inhibitors. | Bioorganic & medicinal chemistry letters 20040105 |
| A novel histone deacetylase inhibitor, scriptaid, enhances expression of functional estrogen receptor alpha (ER) in ER negative human breast cancer cells in combination with 5-aza 2'-deoxycytidine. | Breast cancer research and treatment 20031001 |
| A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library. | Cancer research 20000615 |
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