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27686-84-6 | 1,2-Benzenediol, 4,4'-[(2R,3S)-2,3-dimethyl-1,4-butanediyl]bis-, rel-
CAS No: 27686-84-6 Catalog No: AG002UFP MDL No:
Product Description
Catalog Number:
AG002UFP
Chemical Name:
1,2-Benzenediol, 4,4'-[(2R,3S)-2,3-dimethyl-1,4-butanediyl]bis-, rel-
CAS Number:
27686-84-6
Molecular Formula:
C18H22O4
Molecular Weight:
302.3649
IUPAC Name:
4-[(2S,3R)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol
InChI:
InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3/t11-,12+
InChI Key:
HCZKYJDFEPMADG-TXEJJXNPSA-N
SMILES:
C[C@H]([C@@H](Cc1ccc(c(c1)O)O)C)Cc1ccc(c(c1)O)O
EC Number:
248-606-6
UNII:
7BO8G1BYQU
Properties
Complexity:
303
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
2
Defined Bond Stereocenter Count:
0
Exact Mass:
302.152g/mol
Formal Charge:
0
Heavy Atom Count:
22
Hydrogen Bond Acceptor Count:
4
Hydrogen Bond Donor Count:
4
Isotope Atom Count:
0
Molecular Weight:
302.37g/mol
Monoisotopic Mass:
302.152g/mol
Rotatable Bond Count:
5
Topological Polar Surface Area:
80.9A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4.3
Literature
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| The differentiation-inducing effect of Nordy on HPV-16 subgenes-immortalized human endocervical cells H8. | Anti-cancer drugs 20080801 |
| Inhibition of lipoxygenases and cyclooxygenase-2 enzymes by extracts isolated from Bacopa monniera (L.) Wettst. | Journal of ethnopharmacology 20080723 |
| Synthesis and biological evaluation of 1-(benzenesulfonamido)-2-[5-(N-hydroxypyridin-2(1H)-one)]acetylene regioisomers: a novel class of 5-lipoxygenase inhibitors. | Bioorganic & medicinal chemistry letters 20080715 |
| Sevoflurane and the feto-placental vasculature: the role of nitric oxide and vasoactive eicosanoids. | Anesthesia and analgesia 20080701 |
| Nordihydroguaiaretic acid, a cytotoxic insulin-like growth factor-I receptor/HER2 inhibitor in trastuzumab-resistant breast cancer. | Molecular cancer therapeutics 20080701 |
| The role of laccase in prostaglandin production by Cryptococcus neoformans. | Molecular microbiology 20080601 |
| Nordihydroguaiaretic acid restores expression of silenced E-cadherin gene in human breast cancer cell lines and xenografts. | Anti-cancer drugs 20080601 |
| Phase I clinical trial of repeat dose terameprocol vaginal ointment in healthy female volunteers. | Sexually transmitted diseases 20080601 |
| [Advances in the research of lipoxygenase inhibitors]. | Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20080601 |
| Future target molecules for influenza treatment. | Mini reviews in medicinal chemistry 20080501 |
| Butyrate and trichostatin A attenuate nuclear factor kappaB activation and tumor necrosis factor alpha secretion and increase prostaglandin E2 secretion in human peripheral blood mononuclear cells. | Nutrition research (New York, N.Y.) 20080501 |
| New nordihydroguaiaretic acid derivatives as anti-HIV agents. | Bioorganic & medicinal chemistry letters 20080315 |
| Effect of the interaction between lipoxygenase pathway and progesterone on the regulation of hydroxysteroid 11-Beta dehydrogenase 2 in cultured human term placental trophoblasts. | Biology of reproduction 20080301 |
| Nordihydroguaiaretic acid attenuates potassium dichromate-induced oxidative stress and nephrotoxicity. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080301 |
| Phospholipase A2 activation enhances inhibitory synaptic transmission in rat substantia gelatinosa neurons. | Journal of neurophysiology 20080301 |
| Terameprocol, a novel site-specific transcription inhibitor with anticancer activity. | IDrugs : the investigational drugs journal 20080301 |
| Activity of the lipoxygenase inhibitor 1-phenyl-3-pyrazolidinone (phenidone) and derivatives on the inhibition of adhesion molecule expression on human umbilical vascular endothelial cells. | Biologics : targets & therapy 20080301 |
| Nordihydroguaiaretic acid (NDGA), an inhibitor of the HER2 and IGF-1 receptor tyrosine kinases, blocks the growth of HER2-overexpressing human breast cancer cells. | Journal of cellular biochemistry 20080201 |
| Cytosolic phospholipase A2 and arachidonic acid metabolites modulate ventilator-induced permeability increases in isolated mouse lungs. | Journal of applied physiology (Bethesda, Md. : 1985) 20080201 |
| Unique proteomic features induced by a potential antiglioma agent, Nordy (dl-nordihydroguaiaretic acid), in glioma cells. | Proteomics 20080201 |
| A pilot dose-escalation study of the effects of nordihydroguareacetic acid on hormone and prostate specific antigen levels in patients with relapsed prostate cancer. | BJU international 20080201 |
| [Effect of nordy on the function of endothelial progenitor cells from human umbilical cord blood induced by vascular endothelial growth factor]. | Yao xue xue bao = Acta pharmaceutica Sinica 20080201 |
| Reactivation of methylation-silenced tumor suppressor gene p16INK4a by nordihydroguaiaretic acid and its implication in G1 cell cycle arrest. | Life sciences 20080130 |
| RANTES (CCL5) potentiates calcium ionophore in the production of LTB4 in rat adherent macrophages from granuloma induced by KMnO4: inhibiton by NDGA. | Pharmacological research 20080101 |
| Antigenotoxic effect of nordihydroguaiaretic acid against chlormadinone acetate-induced genotoxicity in mice bone-marrow cells. | Journal of natural medicines 20080101 |
| Organic extracts of Larrea divaricata Cav. induced apoptosis on tumoral MCF7 cells with an higher cytotoxicity than nordihydroguaiaretic acid or paclitaxel. | Journal of experimental therapeutics & oncology 20080101 |
| A simple and robust method for connecting small-molecule drugs using gene-expression signatures. | BMC bioinformatics 20080101 |
| Single-laboratory validated method for determination of nordihydroguaiaretic acid in chaparral-containing dietary supplements. | Journal of AOAC International 20080101 |
| Inhibitory effect of nordihydroguaiaretic acid and its tetra-acetylated derivative on respiration and growth of adenocarcinoma TA3 and its multiresistant variant TA3MTX-R. | In vivo (Athens, Greece) 20080101 |
| Long-range enhancer associated with chromatin looping allows AP-1 regulation of the peptidylarginine deiminase 3 gene in differentiated keratinocyte. | PloS one 20080101 |
| Nordihydroguaiaretic acid inhibits insulin-like growth factor signaling, growth, and survival in human neuroblastoma cells. | Journal of cellular biochemistry 20071215 |
| Copper-induced peroxidation of phosphatidylserine-containing liposomes is inhibited by nanomolar concentrations of specific antioxidants. | Chemistry and physics of lipids 20071201 |
| Phase I/II clinical safety studies of terameprocol vaginal ointment. | Gynecologic oncology 20071201 |
| Nordihydroguaiaretic acid increases endothelial nitric oxide synthase expression via the transcription factor AP-1. | DNA and cell biology 20071201 |
| Tetrahydrofurandiol stimulation of phospholipase A2, lipoxygenase, and cyclooxygenase gene expression and MCF-7 human breast cancer cell proliferation. | Environmental health perspectives 20071201 |
| FcepsilonRI- and Fcgamma receptor-mediated production of reactive oxygen species by mast cells is lipoxygenase- and cyclooxygenase-dependent and NADPH oxidase-independent. | Journal of immunology (Baltimore, Md. : 1950) 20071115 |
| Nordihydroguaiaretic acid induces astroglial death via glutathione depletion. | Journal of neuroscience research 20071101 |
| Inhibition of L-type Ca2+ channel current and negative inotropy induced by arachidonic acid in adult rat ventricular myocytes. | American journal of physiology. Cell physiology 20071101 |
| Inhibitory effect of nordihydroguaiaretic acid, a plant lignan, on Helicobacter pylori-associated gastric carcinogenesis in Mongolian gerbils. | Cancer science 20071101 |
| Penta-acetyl geniposide-induced apoptosis involving transcription of NGF/p75 via MAPK-mediated AP-1 activation in C6 glioma cells. | Toxicology 20070905 |
| A novel lipoxygenase inhibitor Nordy attenuates malignant human glioma cell responses to chemotactic and growth stimulating factors. | Journal of neuro-oncology 20070901 |
| A pinoresinol-lariciresinol reductase homologue from the creosote bush (Larrea tridentata) catalyzes the efficient in vitro conversion of p-coumaryl/coniferyl alcohol esters into the allylphenols chavicol/eugenol, but not the propenylphenols p-anol/isoeugenol. | Archives of biochemistry and biophysics 20070901 |
| Altered mechanisms of endothelium-dependent dilation in skeletal muscle arterioles with genetic hypercholesterolemia. | American journal of physiology. Regulatory, integrative and comparative physiology 20070901 |
| Lipoxygenase inhibitors induce death receptor 5/TRAIL-R2 expression and sensitize malignant tumor cells to TRAIL-induced apoptosis. | Cancer science 20070901 |
| The anticancer activity of the transcription inhibitor terameprocol (meso-tetra-O-methyl nordihydroguaiaretic acid) formulated for systemic administration. | Anti-cancer drugs 20070901 |
| Oxidation of the lignan nordihydroguaiaretic acid. | Chemical research in toxicology 20070901 |
| [Effect of nordy on biological behaviors of malignant glioma cell line U87MG and the analysis of differential expression proteome]. | Zhonghua bing li xue za zhi = Chinese journal of pathology 20070901 |
| Correlation of Golgi localization of ZW10 and centrosomal accumulation of dynactin. | Biochemical and biophysical research communications 20070803 |
| The anti-cancer compound Nordy inhibits CXCR4-mediated production of IL-8 and VEGF by malignant human glioma cells. | Journal of neuro-oncology 20070801 |
| An Aging Interventions Testing Program: study design and interim report. | Aging cell 20070801 |
| Inhibition of IGF-1R and lipoxygenase by nordihydroguaiaretic acid (NDGA) analogs. | Bioorganic & medicinal chemistry letters 20070715 |
| Modification of sericin-free silk fibers for ligament tissue engineering application. | Journal of biomedical materials research. Part B, Applied biomaterials 20070701 |
| A plant lignan, 3'-O-methyl-nordihydroguaiaretic acid, suppresses papillomavirus E6 protein function, stabilizes p53 protein, and induces apoptosis in cervical tumor cells. | Molecular carcinogenesis 20070701 |
| Inhibition of release of vasoactive and inflammatory mediators in airway and vascular tissues and macrophages by a chinese herbal medicine formula for allergic rhinitis. | Evidence-based complementary and alternative medicine : eCAM 20070601 |
| Regulation of topoisomerase II alpha and beta in HIV-1 infected and uninfected neuroblastoma and astrocytoma cells: involvement of distinct nordihydroguaretic acid sensitive inflammatory pathways. | Archives of biochemistry and biophysics 20070501 |
| Endogenous production of reactive oxygen species is required for stimulation of human articular chondrocyte matrix metalloproteinase production by fibronectin fragments. | Free radical biology & medicine 20070501 |
| Monensin causes transient calcium ion influx into mouse splenic lymphocytes in a sodium ion-independent fashion. | European journal of pharmacology 20070430 |
| Effect of heating on peroxynitrite scavenging capacity of garlic. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20070401 |
| Stimulatory activity of lignans from Machilus thunbergii on osteoblast differentiation. | Biological & pharmaceutical bulletin 20070401 |
| Tetra-O-methyl nordihydroguaiaretic acid inhibits growth and induces death of leukemia cells independent of Cdc2 and survivin. | Leukemia & lymphoma 20070401 |
| Protective role of nordihydroguaiaretic acid (NDGA) against the genotoxic damage induced by ethynodiol diacetate in human lymphocytes in vitro. | Journal of environmental biology 20070401 |
| Effect of NC-1900, an active fragment analog of arginine vasopressin, and inhibitors of arachidonic acid metabolism on performance of a passive avoidance task in mice. | European journal of pharmacology 20070329 |
| [Effect of nordy on FPR function of malignant human glioma cell line U87]. | Yao xue xue bao = Acta pharmaceutica Sinica 20070301 |
| [Nordy inhibits cell proliferation and angiogenic factor production of malignant human glioma cells mediated by formylpeptide receptor]. | Zhonghua yi xue za zhi 20070213 |
| Baicalein induction of hydroxyl radical formation via 12-lipoxygenase in human platelets: an ESR study. | Journal of agricultural and food chemistry 20070207 |
| Cancer cells cause vascular endothelial cell (vEC) retraction via 12(S)HETE secretion; the possible role of cancer cell derived microparticle. | Annals of surgical oncology 20070201 |
| Nordihydroguaiaretic acid affects multiple dynein-dynactin functions in interphase and mitotic cells. | Molecular pharmacology 20070201 |
| Development and characteristics of a human cell assay for screening agents for melanoma prevention. | Melanoma research 20070201 |
| 5-LOX inhibitor modulates the inflammatory responses provoked by Helicobacter pylori infection. | Helicobacter 20070201 |
| Effects of arachidonate metabolism inhibitors on basal and human chorionic gonadotropin-stimulated progesterone secretion by rat corpus luteum cells in vitro. | Prostaglandins & other lipid mediators 20070201 |
| Dynamic analysis of ABA accumulation in relation to the rate of ABA catabolism in maize tissues under water deficit. | Journal of experimental botany 20070101 |
| Beta-subunit-dependent modulation of hSlo BK current by arachidonic acid. | Journal of neurophysiology 20070101 |
| Exploiting hypoxia in solid tumors to achieve oncolysis. | Medical hypotheses 20070101 |
| Inhibitors of amyloid beta-protein aggregation mediated by GM1-containing raft-like membranes. | Biochimica et biophysica acta 20070101 |
| Inhibition of release of inflammatory mediators in primary and cultured cells by a Chinese herbal medicine formula for allergic rhinitis. | Chinese medicine 20070101 |
| Interleukin-4 inhibition of interleukin-1-induced expression of matrix metalloproteinase-3 (MMP-3) is independent of lipoxygenase and PPARgamma activation in human gingival fibroblasts. | BMC molecular biology 20070101 |
| Transport characteristics of a novel local drug delivery system using nordihydroguaiaretic acid (NDGA)-polymerized collagen fibers. | Biotechnology progress 20070101 |
| Modulation of hypericin photodynamic therapy by pretreatment with 12 various inhibitors of arachidonic acid metabolism in colon adenocarcinoma HT-29 cells. | Photochemistry and photobiology 20070101 |
| Effect of hydroalcoholic extract of Zingiber officinalis rhizomes on LPS-induced rat airway hyperreactivity and lung inflammation. | Prostaglandins, leukotrienes, and essential fatty acids 20070101 |
| Effects of inhibitors of the arachidonic acid cascade on primary muscle culture from a Duchenne muscular dystrophy patient. | Prostaglandins, leukotrienes, and essential fatty acids 20070101 |
| Early effects triggered by Larrea divaricata Cav. on murine macrophages at apoptotic concentrations. | Immunopharmacology and immunotoxicology 20070101 |
| Current status of monocyte differentiation-inducing (MDI) factors derived from human fetal membrane chorion cells undergoing apoptosis after influenza virus infection. | Gene regulation and systems biology 20070101 |
| Activation and apoptosis of mouse peritoneal macrophages by extracts of Larrea divaricata Cav. (jarilla). | International immunopharmacology 20061220 |
| Synthesis and biological evaluation of a novel class of rofecoxib analogues as dual inhibitors of cyclooxygenases (COXs) and lipoxygenases (LOXs). | Bioorganic & medicinal chemistry 20061201 |
| Enhancing engraftment of neonatal porcine xenoislet with CTLA4Ig and nordihydroguaiaretic acid. | Transplantation proceedings 20061201 |
| Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods. | Journal of molecular graphics & modelling 20061101 |
| Reversal of multidrug resistance by two nordihydroguaiaretic acid derivatives, M4N and maltose-M3N, and their use in combination with doxorubicin or paclitaxel. | Cancer chemotherapy and pharmacology 20061101 |
| Thromboxane mediates neutrophil superoxide production in pregnancy. | American journal of obstetrics and gynecology 20061101 |
| Neurotoxicity of lidocaine involves specific activation of the p38 mitogen-activated protein kinase, but not extracellular signal-regulated or c-jun N-terminal kinases, and is mediated by arachidonic acid metabolites. | Anesthesiology 20061101 |
| Role of 5-lipoxygenase pathway in the regulation of RAW 264.7 macrophage proliferation. | Biochemical pharmacology 20061016 |
| Fibronectin increases matrix metalloproteinase 9 expression through activation of c-Fos via extracellular-regulated kinase and phosphatidylinositol 3-kinase pathways in human lung carcinoma cells. | The Journal of biological chemistry 20061006 |
| Prooxidant activity and toxicity of nordihydroguaiaretic acid in clone-9 rat hepatocyte cultures. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20061001 |
| 5-Hydroxyeicosatetraenoic acid is a key intermediate of the arachidonate-dependent protective signaling in monocytes/macrophages exposed to peroxynitrite. | Journal of leukocyte biology 20061001 |
| Effects of selective inhibition of cyclooxygenase and lipooxygenase pathways in follicle rupture and ovulation in the rat. | Reproduction (Cambridge, England) 20061001 |
| Effects of hyposmotic stress on exocytosis in isolated turbot, Scophthalmus maximus, hepatocytes. | Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20060901 |
| Regulation of the CYP1A1 gene by 2,3,7,8-tetrachlorodibenzo-p-dioxin but not by beta-naphthoflavone or 3-methylcholanthrene is altered in hepatitis C virus replicon-expressing cells. | Molecular pharmacology 20060901 |
| Oxidative stress-driven mechanisms of nordihydroguaiaretic acid-induced apoptosis in FL5.12 cells. | Toxicology and applied pharmacology 20060801 |
| Mediator mechanisms involved in TRPV1 and P2X receptor-mediated, ROS-evoked bradypneic reflex in anesthetized rats. | Journal of applied physiology (Bethesda, Md. : 1985) 20060801 |
| Survivin-dependent and -independent pathways and the induction of cancer cell death by tetra-O-methyl nordihydroguaiaretic acid. | Seminars in oncology 20060801 |
| Single-cell enzyme concentrations, kinetics, and inhibition analysis using high-density hydrodynamic cell isolation arrays. | Analytical chemistry 20060715 |
| Mechanisms regulating tumor angiogenesis by 12-lipoxygenase in prostate cancer cells. | The Journal of biological chemistry 20060707 |
| Monitoring eicosanoid biosynthesis via lipoxygenase and cyclooxygenase pathways in human whole blood by single HPLC run. | Journal of pharmaceutical and biomedical analysis 20060616 |
| The action of extracellular NAD+ on gluconeogenesis in the perfused rat liver. | Molecular and cellular biochemistry 20060601 |
| Anti-ulcerogenic and anti-inflammatory activity of the methanolic extract of Larrea divaricata Cav. in rat. | Journal of ethnopharmacology 20060524 |
| alpha(2)-Adrenergic receptors activate MAPK and Akt through a pathway involving arachidonic acid metabolism by cytochrome P450-dependent epoxygenase, matrix metalloproteinase activation and subtype-specific transactivation of EGFR. | Cellular signalling 20060501 |
| Nordihydroguaiaretic acid is a potent in vitro scavenger of peroxynitrite, singlet oxygen, hydroxyl radical, superoxide anion and hypochlorous acid and prevents in vivo ozone-induced tyrosine nitration in lungs. | Free radical research 20060501 |
| Nordy, a synthetic lipoxygenase inhibitor, inhibits the expression of formylpeptide receptor and induces differentiation of malignant glioma cells. | Biochemical and biophysical research communications 20060421 |
| Overcoming trastuzumab resistance with nordihydroguaiaretic acid? | Breast cancer research and treatment 20060401 |
| Antioxidant compounds have potent anti-fibrillogenic and fibril-destabilizing effects for alpha-synuclein fibrils in vitro. | Journal of neurochemistry 20060401 |
| Alpha-lipoic acid exhibits anti-amyloidogenicity for beta-amyloid fibrils in vitro. | Biochemical and biophysical research communications 20060324 |
| Protective effect of nordihydroguaiaretic acid (NDGA) against norgestrel induced genotoxic damage. | Toxicology in vitro : an international journal published in association with BIBRA 20060301 |
| Differential effect of saturated, monounsaturated, and polyunsaturated fatty acids on alloxan-induced diabetes mellitus. | Prostaglandins, leukotrienes, and essential fatty acids 20060301 |
| Targeting insulin-like growth factor pathways. | British journal of cancer 20060227 |
| Bovine papillomavirus type 1 oncoprotein E5 stimulates the utilization of superoxide radicals in the mouse fibroblast cell line C127. | Chemico-biological interactions 20060225 |
| Effects of nordihydroguaiaretic acid on Na+ currents in rat dorsal root ganglion neurons. | Brain research 20060209 |
| Increased angiogenic capabilities of endothelial cells from microvessels of malignant human gliomas. | International immunopharmacology 20060101 |
| Activation of p38 MAPKinase/cPLA2 pathway in homocysteine-treated platelets. | Journal of thrombosis and haemostasis : JTH 20060101 |
| Primary glia expressing the G93A-SOD1 mutation present a neuroinflammatory phenotype and provide a cellular system for studies of glial inflammation. | Journal of neuroinflammation 20060101 |
| Glucose metabolism in isolated uteri of immature rats. Influence of prostaglandins and nitric oxide. | Reproduction, nutrition, development 20060101 |
| Blockade of arachidonic acid pathway induces sprouting in the adult but not in the neonatal uncrossed retinotectal projection. | Neuroscience 20060101 |
| Downregulation of survivin expression and concomitant induction of apoptosis by celecoxib and its non-cyclooxygenase-2-inhibitory analog, dimethyl-celecoxib (DMC), in tumor cells in vitro and in vivo. | Molecular cancer 20060101 |
| Purification, product characterization and kinetic properties of lipoxygenase from olive fruit (Olea europaea L.). | Plant physiology and biochemistry : PPB 20060101 |
| Pharmacological inhibition of leukotrienes in an animal model of bleomycin-induced acute lung injury. | Respiratory research 20060101 |
| Eicosanoid-mediated proinflammatory activity of Pseudomonas aeruginosa ExoU. | Cellular microbiology 20051201 |
| Linoleic acid, but not oleic acid, upregulates production of interleukin-8 by human vascular smooth muscle cells via arachidonic acid metabolites under conditions of oxidative stress. | Journal of the Society for Gynecologic Investigation 20051201 |
| Leukotoxin diols from ground corncob bedding disrupt estrous cyclicity in rats and stimulate MCF-7 breast cancer cell proliferation. | Environmental health perspectives 20051201 |
| Structure-activity relationship of polyphenols that inhibit fatty acid synthase. | Journal of biochemistry 20051201 |
| Nordihydroguaiaretic acid (NDGA) inhibits the IGF-1 and c-erbB2/HER2/neu receptors and suppresses growth in breast cancer cells. | Breast cancer research and treatment 20051101 |
| Inhibition of 12- and 15-lipoxygenase activities and protection of human and tilapia low density lipoprotein oxidation by I-Tiao-Gung (Glycine tomentella). | Lipids 20051101 |
| Molecular targets of dietary polyphenols with anti-inflammatory properties. | Yonsei medical journal 20051031 |
| Development of an enzyme-modified carbon paste electrode for determining inhibitors of lipoxygenase. | Biosensors & bioelectronics 20051015 |
| Role of arachidonic acid in hyposmotic membrane stretch-induced increase in calcium-activated potassium currents in gastric myocytes. | Acta pharmacologica Sinica 20051001 |
| The anti-apoptotic effects of nordihydroguaiaretic acid: inhibition of cPLA(2) activation during TNF-induced apoptosis arises from inhibition of calcium signaling. | Life sciences 20050923 |
| 15S-Lipoxygenase-2 mediates arachidonic acid-stimulated adhesion of human breast carcinoma cells through the activation of TAK1, MKK6, and p38 MAPK. | The Journal of biological chemistry 20050909 |
| Conjugated linoleic acid, cis-9,trans-11, is a substrate for pulmonary 15-lipoxygenase-1 in rat. | Journal of agricultural and food chemistry 20050907 |
| Effect of Larrea tridentata (creosote bush) on cholesterol gallstones and bile secretion in hamsters. | The Journal of pharmacy and pharmacology 20050901 |
| Antimycobacterial agents from selected Mexican medicinal plants. | The Journal of pharmacy and pharmacology 20050901 |
| Thromboxane A2 up-regulates neutrophil elastase release in Syrian hamsters with trinitrobenzene sulfonic acid-induced colitis. | Journal of pharmacological sciences 20050801 |
| Involvement of phospholipase A2 and lipoxygenase in lipopolysaccharide-induced inducible nitric oxide synthase expression in glial cells. | Glia 20050701 |
| Arachidonic acid induces neuronal death through lipoxygenase and cytochrome P450 rather than cyclooxygenase. | Journal of neuroscience research 20050701 |
| 5-Lipoxygenase inhibitors attenuate growth of human renal cell carcinoma and induce apoptosis through arachidonic acid pathway. | Oncology reports 20050701 |
| Intracellular free radical production in synovial T lymphocytes from patients with rheumatoid arthritis. | Arthritis and rheumatism 20050701 |
| A Thrombelastograph whole blood assay for clinical monitoring of NSAID-insensitive transcellular platelet activation by arachidonic acid. | The Journal of laboratory and clinical medicine 20050701 |
| Acute and chronic effects of eicosapentaenoic acid on voltage-gated sodium channel expressed in cultured human bronchial smooth muscle cells. | Biochemical and biophysical research communications 20050617 |
| Systemic treatment with tetra-O-methyl nordihydroguaiaretic acid suppresses the growth of human xenograft tumors. | Clinical cancer research : an official journal of the American Association for Cancer Research 20050615 |
| A redox-sensitive pathway mediates oxidized LDL-induced downregulation of insulin-like growth factor-1 receptor. | Journal of lipid research 20050601 |
| Multiple actions of halothane on contractile response to noradrenaline in isolated mesenteric resistance arteries. | Naunyn-Schmiedeberg's archives of pharmacology 20050601 |
| Determination and confirmation of five phenolic antioxidants in foods by LC/MS and GC/MS. | Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20050601 |
| The effects of nitric oxide synthase--versus lipoxygenase inhibition on coronary flow and nitrite outflow in isolated rat heart. | General physiology and biophysics 20050601 |
| Survival prolongation of microencapsulated allogeneic islet by nanosized nordihydroguaiaretic acid. | Transplantation proceedings 20050501 |
| Preformed beta-amyloid fibrils are destabilized by coenzyme Q10 in vitro. | Biochemical and biophysical research communications 20050429 |
| Larrea tridentata (Creosote bush), an abundant plant of Mexican and US-American deserts and its metabolite nordihydroguaiaretic acid. | Journal of ethnopharmacology 20050426 |
| Leukotriene and prostaglandin synthesis pathways in osteoarthritic synovial membranes: regulating factors for interleukin 1beta synthesis. | The Journal of rheumatology 20050401 |
| Nordihydroguaiaretic acid inhibits IFN-gamma-induced STAT tyrosine phosphorylation in rat brain astrocytes. | Biochemical and biophysical research communications 20050311 |
| Nordihydroguaiaretic acid (NDGA) blocks the differentiation of C2C12 myoblast cells. | Journal of cellular physiology 20050301 |
| CDC2/CDK1 expression in esophageal adenocarcinoma and precursor lesions serves as a diagnostic and cancer progression marker and potential novel drug target. | The American journal of surgical pathology 20050301 |
| Effects of methylprednisolone on the neural conduction of the motor evoked potentials in spinal cord injured rats. | Journal of Korean medical science 20050201 |
| Cyclooxygenase- and lipoxygenase-dependent relaxation to arachidonic acid in rabbit small mesenteric arteries. | American journal of physiology. Heart and circulatory physiology 20050101 |
| Sensitization of colon cancer cell lines to butyrate-mediated proliferation inhibition by combined application of indomethacin and nordihydroguaiaretic acid. | Cancer detection and prevention 20050101 |
| Inhibition of influenza-virus-induced apoptosis in chorion cells of human fetal membranes by nordihydroguaiaretic Acid. | Intervirology 20050101 |
| Anti-inflammatory effects of specific cyclooxygenase 2,5-lipoxygenase, and inducible nitric oxide synthase inhibitors on experimental autoimmune anterior uveitis (EAAU). | Ocular immunology and inflammation 20050101 |
| Platelet aggregation and vasoconstriction related to platelet cyclooxygenase and 12-lipoxygenase pathways. | Journal of atherosclerosis and thrombosis 20050101 |
| Phospholipase A2 activation by melittin enhances spontaneous glutamatergic excitatory transmission in rat substantia gelatinosa neurons. | Neuroscience 20050101 |
| Group IIA secretory phospholipase A2 is a unique 12/15-lipoxygenase-regulated gene in cytokine-stimulated rat fibroblastic 3Y1 cells. | Biochimica et biophysica acta 20041108 |
| Anti-amyloidogenic activity of tannic acid and its activity to destabilize Alzheimer's beta-amyloid fibrils in vitro. | Biochimica et biophysica acta 20041105 |
| Suppression of heat- and polyglutamine-induced cytotoxicity by nonsteroidal anti-inflammatory drugs. | European journal of biochemistry 20041101 |
| Arachidonic acid regulation of steroid synthesis: new partners in the signaling pathway of steroidogenic hormones. | Endocrine research 20041101 |
| Multiple contributions from long-chain fatty acid metabolism in Y-1 and MA-10 cells. | Endocrine research 20041101 |
| The arachidonic acid 5-lipoxygenase inhibitor nordihydroguaiaretic acid inhibits tumor necrosis factor alpha activation of microglia and extends survival of G93A-SOD1 transgenic mice. | Journal of neurochemistry 20041001 |
| Nordihydroguaiaretic acid-induced Ca2+ handling and cytotoxicity in human prostate cancer cells. | Life sciences 20040924 |
| Lignoids in insects: chemical probes for the study of ecdysis, excretion and Trypanosoma cruzi-triatomine interactions. | Toxicon : official journal of the International Society on Toxinology 20040915 |
| Nordihydroguairetic acid, a lignin, prevents oxidative stress and the development of diabetic nephropathy in rats. | Pharmacology 20040901 |
| Nordihydroguaiaretic acid does not disaggregate beta-amyloid(1-40) protofibrils but does inhibit growth arising from direct protofibril association. | Molecular pharmacology 20040901 |
| Biochemical and immunochemical evidences for the presence of lipoxygenase in plant mitochondria. | Journal of experimental botany 20040801 |
| Activation of Na+-independent Mg2+ efflux by 20-hydroxyeicosatetraenoic acid in rat renal epithelial cells. | The Japanese journal of physiology 20040801 |
| Stimulatory actions of caffeic acid phenethyl ester, a known inhibitor of NF-kappaB activation, on Ca2+-activated K+ current in pituitary GH3 cells. | The Journal of biological chemistry 20040625 |
| A new lead compound for abscisic acid biosynthesis inhibitors targeting 9-cis-epoxycarotenoid dioxygenase. | Bioorganic & medicinal chemistry letters 20040621 |
| Prostaglandin F(2alpha) is protective for apoptosis stimulated synergistically with 12-O-tetradecanoyl phorbol-beta-acetate and nordihydroguaiaretic acid in Madin-Darby canine kidney cells. | Biochimica et biophysica acta 20040601 |
| Histamine-induced Ca(2+) influx via the PLA(2)/lipoxygenase/TRPV1 pathway in rat sensory neurons. | Neuroscience letters 20040506 |
| Effect of Larrea divaricata Cav. extract and nordihydroguaiaretic acid upon peroxidase secretion in rat submandibulary glands. | Pharmacological research 20040501 |
| Inhibitors of 5-lipoxygenase inhibit expression of intercellular adhesion molecule-1 in human melanoma cells. | Acta pharmacologica Sinica 20040501 |
| BK2 but not BK1 receptors mediating contractile response in human umbilical arteries: role of thromboxane A2. | Methods and findings in experimental and clinical pharmacology 20040501 |
| Involvement of spinal lipoxygenase metabolites in hyperalgesia and opioid tolerance. | European journal of pharmacology 20040426 |
| Substance P can stimulate prostaglandin D2 and leukotriene C4 generation without granule exocytosis in murine mast cells. | European journal of pharmacology 20040405 |
| Presynaptic kainate receptors modulating glutamatergic transmission in the rat hippocampus are inhibited by arachidonic acid. | Neurochemistry international 20040401 |
| Linoleic acid induces interleukin-8 production by Crohn's human intestinal smooth muscle cells via arachidonic acid metabolites. | American journal of physiology. Gastrointestinal and liver physiology 20040401 |
| Interleukin-17 signal transduction pathways implicated in inducing matrix metalloproteinase-3, -13 and aggrecanase-1 genes in articular chondrocytes. | Cellular signalling 20040401 |
| Inhibition of AP-1 transcription activator induces myc-dependent apoptosis in HL60 cells. | Journal of cellular biochemistry 20040401 |
| A stepwise dissection of the intracellular fate of cationic cell-penetrating peptides. | The Journal of biological chemistry 20040326 |
| Curcumin has potent anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro. | Journal of neuroscience research 20040315 |
| Adipocyte differentiation of multipotent cells established from human adipose tissue. | Biochemical and biophysical research communications 20040305 |
| Ca2+ influx is not involved in acute cytotoxicity of arachidonic acid. | Biochemical pharmacology 20040301 |
| Determination of binding constant of transcription factor myc-max/max-max and E-box DNA: the effect of inhibitors on the binding. | Biochimica et biophysica acta 20040224 |
| The effects of TNF-alpha and inhibitors of arachidonic acid metabolism on human colon HT-29 cells depend on differentiation status. | Differentiation; research in biological diversity 20040201 |
| TGSA-Flex: Extending the capabilities of the Topo-Geometrical Superposition Algorithm to handle flexible molecules. | Journal of computational chemistry 20040130 |
| Estrogenic activity of an antioxidant, nordihydroguaiaretic acid (NDGA). | Life sciences 20040130 |
| Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake. | The Journal of biological chemistry 20040109 |
| Tetrapetalone A, a novel lipoxygenase inhibitor from Streptomyces sp. | Bioscience, biotechnology, and biochemistry 20040101 |
| Effects of eicosanoid biosynthesis inhibitors on the prophenoloxidase-activating system and microaggregation reactions in the hemolymph of Rhodnius prolixus infected with Trypanosoma rangeli. | Journal of insect physiology 20040101 |
| Islet transplantation: an update. | Chang Gung medical journal 20040101 |
| 15-LOX-1 inhibits p21 (Cip/WAF 1) expression by enhancing MEK-ERK 1/2 signaling in colon carcinoma cells. | Prostaglandins & other lipid mediators 20040101 |
| In vitro proliferation of fibrosarcoma cells depends on intact functions of lipoxygenases and cytochrome P-450-monooxygenase. | Cancer investigation 20040101 |
| Arachidonic acid-activated Na+-dependent Mg2+ efflux in rat renal epithelial cells. | Biochimica et biophysica acta 20031203 |
| 11,12,15-Trihydroxyeicosatrienoic acid mediates ACh-induced relaxations in rabbit aorta. | American journal of physiology. Heart and circulatory physiology 20031201 |
| PAF-like lipids- and PAF-induced gallbladder muscle contraction is mediated by different pathways in guinea pigs. | American journal of physiology. Gastrointestinal and liver physiology 20031201 |
| Intracellular proteins involved in Porphyromonas gingivalis-induced opsonophagocytic activities of a murine macrophage cell line (RAW264.7 cells). | Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 20031201 |
| Inhibitory action of ICI-182,780, an estrogen receptor antagonist, on BK(Ca) channel activity in cultured endothelial cells of human coronary artery. | Biochemical pharmacology 20031115 |
| Dihydrolipoic acid inhibits 15-lipoxygenase-dependent lipid peroxidation. | Free radical biology & medicine 20031115 |
| Arachidonic acid metabolites contribute to the irreversible depolarization induced by in vitro ischemia. | Journal of neurophysiology 20031101 |
| Inhibition of neutrophil leukotriene B4 production by a novel synthetic N-3 polyunsaturated fatty acid analogue, beta-oxa 21:3n-3. | Journal of immunology (Baltimore, Md. : 1950) 20031101 |
| Lipoxygenase inhibitors enhance tumor suppressive effects of jun proteins on v-myb-transformed monoblasts BM2. | Prostaglandins & other lipid mediators 20031101 |
| Adipocyte differentiation of 3T3-L1 preadipocytes is dependent on lipoxygenase activity during the initial stages of the differentiation process. | The Biochemical journal 20031101 |
| Naturally occurring lignans efficiently induce apoptosis in colorectal tumor cells. | Journal of cancer research and clinical oncology 20031001 |
| Nordihydroguaiaretic acid, an antioxidant, inhibits transforming growth factor-beta activity through the inhibition of Smad signaling pathway. | Experimental cell research 20031001 |
| The role of oxidant-mediated pathways in the cytotoxicity of endothelial cells exposed to mesenteric lymph from rats subjected to trauma-hemorrhagic shock. | Shock (Augusta, Ga.) 20030901 |
| Spinal administration of lipoxygenase inhibitors suppresses behavioural and neurochemical manifestations of naloxone-precipitated opioid withdrawal. | British journal of pharmacology 20030901 |
| Induction of tumor necrosis factor-alpha by UVB: a role for reactive oxygen intermediates and eicosanoids. | Photochemistry and photobiology 20030701 |
| Nitric oxide triggers the toxicity due to glutathione depletion in midbrain cultures through 12-lipoxygenase. | The Journal of biological chemistry 20030613 |
| Roles of 5-lipoxygenase activating protein in cell proliferation and apoptosis. | Cell biology and toxicology 20030601 |
| Neuroprotection by the endogenous cannabinoid anandamide and arvanil against in vivo excitotoxicity in the rat: role of vanilloid receptors and lipoxygenases. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20030515 |
| Fatty acid release and oxidation are factors in lipoxygenase inhibitor-induced apoptosis. | Toxicology letters 20030303 |
| Mechanical and thermal properties of novel polymerized NDGA-gelatin hydrogels. | Biomaterials 20030301 |
| Inhibition of HSV-1 replication and reactivation by the mutation-insensitive transcription inhibitor tetra-O-glycyl-nordihydroguaiaretic acid. | Antiviral research 20030301 |
| Novel antiviral agent tetraglycylated nordihydroguaiaretic acid hydrochloride as a host-dependent viral inhibitor. | Antiviral research 20030301 |
| Oxidant-stimulated chloride secretion in rat jejunum in vitro is mediated by eicosanoids. | Digestive diseases and sciences 20030301 |
| Direct interaction of the Golgi membrane with the endoplasmic reticulum membrane caused by nordihydroguaiaretic acid. | Biochemical and biophysical research communications 20030221 |
| Inhibition by eicosapentaenoic acid of IL-1beta-induced PGHS-2 expression in human microvascular endothelial cells: involvement of lipoxygenase-derived metabolites and p38 MAPK pathway. | Biochimica et biophysica acta 20030220 |
| Abnormalities in intracellular Ca2+ regulation in fetal vascular smooth muscle in pre-eclampsia: enhanced sensitivity to arachidonic acid. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030201 |
| Role of arachidonic acid and protein kinase C during maturation-inducing hormone-dependent meiotic resumption and ovulation in ovarian follicles of Atlantic croaker. | Biology of reproduction 20030201 |
| Arachidonic acid and anandamide have opposite modulatory actions at the glycine transporter, GLYT1a. | Journal of neurochemistry 20030201 |
| Lipoxygenase products regulate nitric oxide and inducible nitric oxide synthase production in interleukin-1beta stimulated vascular smooth muscle cells. | Hypertension research : official journal of the Japanese Society of Hypertension 20030201 |
| IL-4 induces apoptosis in A549 lung adenocarcinoma cells: evidence for the pivotal role of 15-hydroxyeicosatetraenoic acid binding to activated peroxisome proliferator-activated receptor gamma transcription factor. | Journal of immunology (Baltimore, Md. : 1950) 20030115 |
| Ex-vivo regulation of endotoxin-induced tissue factor in whole blood by eicosanoids. | Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20030101 |
| Rat breast microsomal biotransformation of ethanol to acetaldehyde but not to free radicals: its potential role in the association between alcohol drinking and breast tumor promotion. | Teratogenesis, carcinogenesis, and mutagenesis 20030101 |
| Mepanipyrim, a novel inhibitor of pharmacologically induced Golgi dispersion. | Bioscience, biotechnology, and biochemistry 20030101 |
| Nordihydroguaiaretic acid, of a new family of microtubule-stabilizing agents, shows effects differentiated from paclitaxel. | Bioscience, biotechnology, and biochemistry 20030101 |
| Eicosanoid precursor polyenoic fatty acids modulate synaptic levels of dopamine in ex-vivo slices of rat brain striatum. | In vivo (Athens, Greece) 20030101 |
| [Effect of inhibitors of cyclooxygenase and lypoxygenase pathway of metabolism of arachidonic acid on the development and suppression of the immune response in mice]. | Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20030101 |
| Lipoxygenase inhibitors suppress proliferation of G5:113 fibrosarcoma cells in vitro but they have no anticancer activity in vivo. | Neoplasma 20030101 |
| Prostaglandin F2alpha protected cultured Madin-Darby canine kidney cells from the development of apoptosis induced by 12-o-tetradecanoyl phorbol-beta-acetate and stimulated synergistically with nordihydroguaiaretic acid. | Advances in experimental medicine and biology 20030101 |
| Steroidal regulation of uterine resistance to bacterial infection in livestock. | Reproductive biology and endocrinology : RB&E 20030101 |
| BAD and Bcl-2 regulation are early events linking neuronal endoplasmic reticulum stress to mitochondria-mediated apoptosis. | Brain research. Molecular brain research 20021230 |
| Nordihydroguaiaretic acid: hepatotoxicity and detoxification in the mouse. | Toxicon : official journal of the International Society on Toxinology 20021201 |
| Aberrant arachidonic acid metabolism in esophageal adenocarcinogenesis, and the effects of sulindac, nordihydroguaiaretic acid, and alpha-difluoromethylornithine on tumorigenesis in a rat surgical model. | Carcinogenesis 20021201 |
| Transport of phenolic compounds from leaf surface of creosotebush and tarbush to soil surface by precipitation. | Journal of chemical ecology 20021201 |
| [Lipoxygenase-mediated N-demethylation of pesticides in vitro]. | Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20021201 |
| Establishment of a first-order kinetic model of light chain-associated amyloid fibril extension in vitro. | Biochimica et biophysica acta 20021119 |
| Concerted regulation of free arachidonic acid and hormone-induced steroid synthesis by acyl-CoA thioesterases and acyl-CoA synthetases in adrenal cells. | European journal of biochemistry 20021101 |
| ACTH regulation of mitochondrial acyl-CoA thioesterase activity in Y1 adrenocortical tumour cells. | Endocrine research 20021101 |
| Bradykinin increases permeability by calcium and 5-lipoxygenase in the ECV304/C6 cell culture model of the blood-brain barrier. | Brain research 20021025 |
| Effect of nordihydroguaiaretic acid on intracellular Ca(2+) concentrations in hepatocytes. | Toxicology in vitro : an international journal published in association with BIBRA 20021001 |
| Contribution of different phospholipases and arachidonic acid metabolites in the response of gallbladder smooth muscle to cholecystokinin. | Biochemical pharmacology 20021001 |
| Investigation of the role of lipoxygenase in bioactivation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in human lung. | Chemical research in toxicology 20021001 |
| Effect of nordihydroguaiaretic acid on the secretion of lipoprotein lipase. | Journal of biochemistry and molecular biology 20020930 |
| Inhibition of peroxisome proliferator-activated receptor (PPAR)-mediated keratinocyte differentiation by lipoxygenase inhibitors. | The Biochemical journal 20020915 |
| Design, synthesis, and biological evaluation of a cephalosporin-monohydroguaiaretic acid prodrug activated by a monoclonal antibody-beta-lactamase conjugate. | Bioorganic & medicinal chemistry 20020901 |
| N-acylethanolamines are metabolized by lipoxygenase and amidohydrolase in competing pathways during cottonseed imbibition. | Plant physiology 20020901 |
| Platelet aggregating response to platelet activating factor participates in activation of the 12-lipoxygenase pathway in platelets from rabbits. | International angiology : a journal of the International Union of Angiology 20020901 |
| Lipoxygenase inhibitors attenuate growth of human pancreatic cancer xenografts and induce apoptosis through the mitochondrial pathway. | Molecular cancer therapeutics 20020901 |
| Neurons overexpressing mutant presenilin-1 are more sensitive to apoptosis induced by endoplasmic reticulum-Golgi stress. | Journal of neuroscience research 20020815 |
| Kinetics of inhibition of leukocyte 12-lipoxygenase by the isoform-specific inhibitor 4-(2-oxapentadeca-4-yne)phenylpropanoic acid. | Biochemistry 20020813 |
| Stimulatory effects of adenosine on prolactin secretion in the pituitary gland of the rat. | Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20020701 |
| Structure-activity relationship studies of nordihydroguaiaretic acid inhibitors toward soybean, 12-human, and 15-human lipoxygenase. | Journal of medicinal chemistry 20020606 |
| Participation of the arachidonic acid cascade pathway in macrophage binding/uptake of oxidized low density lipoprotein. | Biological & pharmaceutical bulletin 20020601 |
| Nordihydroguaiaretic acid-mediated inhibition of ultraviolet B-induced activator protein-1 activation in human keratinocytes. | Molecular carcinogenesis 20020601 |
| alpha 2B-adrenergic receptor activates MAPK via a pathway involving arachidonic acid metabolism, matrix metalloproteinases, and epidermal growth factor receptor transactivation. | The Journal of biological chemistry 20020531 |
| Contractile response to a cannabimimetic eicosanoid, 2-arachidonoylglycerol, of longitudinal smooth muscle from the guinea-pig distal colon in vitro. | European journal of pharmacology 20020531 |
| Effects of brefeldin A and nordihydroguaiaretic acid on endomembrane dynamics and lipid synthesis in plant cells. | FEBS letters 20020508 |
| Effects of cyclooxygenase and lipoxygenase inhibition on basal- and serotonin-induced ion transport in rat colon. | Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20020501 |
| Involvement of glycogen synthase kinase-3beta and tau phosphorylation in neuronal Golgi disassembly. | Journal of neurochemistry 20020501 |
| Nordihydroguaiaretic acid potently breaks down pre-formed Alzheimer's beta-amyloid fibrils in vitro. | Journal of neurochemistry 20020501 |
| Mechanisms underlying the activation of large conductance Ca2+-activated K+ channels by nordihydroguaiaretic acid. | Japanese journal of pharmacology 20020501 |
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
| Mechanisms of nordihydroguaiaretic acid-induced growth inhibition and apoptosis in human cancer cells. | British journal of cancer 20020408 |
| [Simultaneous determination of five antioxidants in food by HPLC with fluorescence detection]. | Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20020401 |
| Comparative quantitative structure toxicity relationships for flavonoids evaluated in isolated rat hepatocytes and HeLa tumor cells. | Chemico-biological interactions 20020320 |
| Structure-activity relationships for inhibition of human 5alpha-reductases by polyphenols. | Biochemical pharmacology 20020315 |
| Effect of nordihydroguaiaretic acid on intracellular Ca(2+) concentrations in C6 glioma cells. | Neurochemistry international 20020301 |
| Possible implication of Golgi-nucleating function for the centrosome. | Biochemical and biophysical research communications 20020301 |
| Expression and induction of the stress protein alpha-B-crystallin in vascular endothelial cells. | Histochemistry and cell biology 20020301 |
| Effects of various reactive oxygen species on the guinea pig trachea and its epithelium. | Japanese journal of pharmacology 20020301 |
| Effects of inhibitors of the lipo-oxygenase family of enzymes on the store-operated calcium current I(CRAC) in rat basophilic leukaemia cells. | The Journal of physiology 20020215 |
| Tending tender tendons. | Science (New York, N.Y.) 20020208 |
| Reactive oxygen species as downstream mediators of angiogenic signaling by vascular endothelial growth factor receptor-2/KDR. | The Journal of biological chemistry 20020201 |
| 5-Lipoxygenase and human pulmonary artery endothelial cell proliferation. | American journal of physiology. Heart and circulatory physiology 20020201 |
| Arachidonic and linoleic acid metabolism in mouse intestinal tissue: evidence for novel lipoxygenase activity. | Archives of biochemistry and biophysics 20020201 |
| Multiple biological effects of inhibitors of arachidonic acid metabolism on human keratinocytes. | Archives of dermatological research 20020201 |
| Native LDL induces proliferation of human vascular smooth muscle cells via redox-mediated activation of ERK 1/2 mitogen-activated protein kinases. | Hypertension (Dallas, Tex. : 1979) 20020201 |
| Differential effect of brefeldin A on the palmitoylation of surfactant protein C proprotein mutants. | Biochemical and biophysical research communications 20020111 |
| The lipoxygenase pathways are involved in LH-stimulated progesterone production in bovine corpus luteum. | Prostaglandins & other lipid mediators 20020101 |
| Evidence for the involvement of cyclooxygenase activity in the development of cocaine sensitization. | Pharmacology, biochemistry, and behavior 20020101 |
| Cytosolic phospholipase A2 and lipoxygenase are involved in cell cycle progression in neuroblastoma cells. | Cellular and molecular life sciences : CMLS 20020101 |
| [Effect of exogenous leukotrienes and lipoxygenase inhibitors on apoptosis and necrosis in cultured rat hepatocytes]. | Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20020101 |
| [Lipoxygenase inhibitors induce rat hepatocyte apoptosis in primary culture]. | Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20020101 |
| Regulation of apoptosis through arachidonate cascade in mammalian cells. | Applied biochemistry and biotechnology 20020101 |
| Lipoxygenase inhibitors induce arrest of tumor cells in S-phase of the cell cycle. | Neoplasma 20020101 |
| Progressive apoptosis in chorion laeve trophoblast cells of human fetal membrane tissues during in vitro incubation is suppressed by antioxidative reagents. | European journal of biochemistry 20011201 |
| Nordihydroguaiaretic acid elevates osteoblastic intracellular Ca2+. | Pharmacology & toxicology 20011201 |
| Synthesis and anticancer activity of nordihydroguaiaretic acid (NDGA) and analogues. | Anti-cancer drug design 20011201 |
| Lipoxygenase inhibitors inhibit heparin-releasable lipoprotein lipase activity in 3T3-L1 adipocytes and enhance body fat reduction in mice by conjugated linoleic acid. | Biochimica et biophysica acta 20011130 |
| 5-lipoxygenase regulates malignant mesothelial cell survival: involvement of vascular endothelial growth factor. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20011101 |
| Fenamates stimulate BKCa channel osteoblast-like MG-63 cells activity in the human. | Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20011101 |
| Intracellular signaling pathway of FGF-2-modulated corneal endothelial cell migration during wound healing in vitro. | Experimental eye research 20011101 |
| Eicosanoids participate in the regulation of cardiac glucose transport by contribution to a rearrangement of actin cytoskeletal elements. | The Biochemical journal 20011001 |
| Histamine stimulates alveolar macrophages to release neutrophil and monocyte chemotactic activity. | The Journal of laboratory and clinical medicine 20011001 |
| tetra-O-methylnordihydroguaiaretic acid inhibits melanoma in vivo. | Cancer letters 20010928 |
| trans-10,cis-12-Conjugated linoleic acid reduces leptin secretion from 3T3-L1 adipocytes. | Biochemical and biophysical research communications 20010921 |
| Differential role of cytosolic phospholipase A2 in the invasion of brain microvascular endothelial cells by Escherichia coli and Listeria monocytogenes. | The Journal of infectious diseases 20010915 |
| Involvement of the 5-lipoxygenase pathway in the neurotoxicity of the prion peptide PrP106-126. | Journal of neuroscience research 20010915 |
| Elevating dietary salt exacerbates hyperpnea-induced airway obstruction in guinea pigs. | Journal of applied physiology (Bethesda, Md. : 1985) 20010901 |
| Pharmacological modulation of allergic inflammation in the rat airways and association with mast cell heterogeneity. | European journal of pharmacology 20010824 |
| Johns Hopkins embroiled in fresh misconduct allegations. | Nature 20010802 |
| Characterization of clofibrate-induced retrograde Golgi membrane movement to the endoplasmic reticulum: clofibrate distinguishes the Golgi from the trans Golgi network. | Bioscience, biotechnology, and biochemistry 20010801 |
| Activation of the phosphatidylinositol 3-kinase-Akt/protein kinase B signaling pathway in arachidonic acid-stimulated human myeloid and endothelial cells: involvement of the ErbB receptor family. | The Journal of biological chemistry 20010720 |
| Baicalein protects cortical neurons from beta-amyloid (25-35) induced toxicity. | Neuroreport 20010720 |
| Tetra-O-methyl nordihydroguaiaretic acid induces G2 arrest in mammalian cells and exhibits tumoricidal activity in vivo. | Cancer research 20010715 |
| Inhibitors of arachidonic acid metabolism potentiate tumour necrosis factor-alpha-induced apoptosis in HL-60 cells. | European journal of pharmacology 20010713 |
| Biocompatibility of NDGA-polymerized collagen fibers. I. Evaluation of cytotoxicity with tendon fibroblasts in vitro. | Journal of biomedical materials research 20010701 |
| Biocompatibility of NDGA-polymerized collagen fibers. II. Attachment, proliferation, and migration of tendon fibroblasts in vitro. | Journal of biomedical materials research 20010701 |
| Arachidonate dilates basilar artery by lipoxygenase-dependent mechanism and activation of K(+) channels. | American journal of physiology. Regulatory, integrative and comparative physiology 20010701 |
| Activation of cardiac afferents by arachidonic acid: relative contributions of metabolic pathways. | American journal of physiology. Heart and circulatory physiology 20010701 |
| Generation of 8-epi-prostaglandin F(2alpha) in isolated rat kidney glomeruli by a radical-independent mechanism. | British journal of pharmacology 20010701 |
| Fatty acids inhibit anion secretion in rat colon: apical and basolateral action sites. | Pflugers Archiv : European journal of physiology 20010701 |
| Pharmacologic properties of brewery dust extracts in vitro. | Chest 20010601 |
| Glucosylceramide synthesis inhibitors block pharmacologically induced dispersal of the Golgi and anterograde membrane flow from the endoplasmic reticulum: implication of sphingolipid metabolism in maintenance of the Golgi architecture and anterograde membrane flow. | Bioscience, biotechnology, and biochemistry 20010601 |
| Regulation of 15-lipoxygenase isozymes and mucin secretion by cytokines in cultured normal human bronchial epithelial cells. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20010601 |
| Arachidonic acid modulates the spatiotemporal characteristics of agonist-evoked Ca2+ waves in mouse pancreatic acinar cells. | The Journal of biological chemistry 20010518 |
| Disparate effects of similar phenolic phytochemicals as inhibitors of oxidative damage to cellular DNA. | Mutation research 20010510 |
| Acetylcholine-induced positive inotropy mediated by prostaglandin released from endocardial endothelium in mouse left atrium. | Naunyn-Schmiedeberg's archives of pharmacology 20010501 |
| Mechanisms of cytokine-induced death of cultured bovine luteal cells. | Reproduction (Cambridge, England) 20010501 |
| Pharmacokinetic analysis by high-performance liquid chromatography of intravenous nordihydroguaiaretic acid in the mouse. | Journal of chromatography. B, Biomedical sciences and applications 20010415 |
| Modulation of the immediate allergic wheal reaction in the skin by drugs inhibiting the effects of leukotriene C4 and prostaglandin D2. | European journal of clinical pharmacology 20010401 |
| Co-existing proteins interfere with the action of nordihydroguaiaretic acid on retrograde Golgi-to-ER protein trafficking in NRK cells and alpha-glucosidase reaction in vitro. | Bioscience, biotechnology, and biochemistry 20010401 |
| Arachidonic acid stimulates glucose uptake in 3T3-L1 adipocytes by increasing GLUT1 and GLUT4 levels at the plasma membrane. Evidence for involvement of lipoxygenase metabolites and peroxisome proliferator-activated receptor gamma. | The Journal of biological chemistry 20010323 |
| Arachidonyltrifluoromethy ketone, a phospholipase A(2) antagonist, induces dispersal of both Golgi stack- and trans Golgi network-resident proteins throughout the cytoplasm. | Biochemical and biophysical research communications 20010223 |
| Determination of binding constant of transcription factor AP-1 and DNA. Application of inhibitors. | European journal of biochemistry 20010201 |
| New bis-catechols 5-lipoxygenase inhibitors. | Bioorganic & medicinal chemistry 20010201 |
| Serum-dependent perinuclear accumulation of Cdc42 in mammalian cells. | Oncology reports 20010101 |
| Oxidized low density lipoprotein induces apoptosis via generation of reactive oxygen species in vascular smooth muscle cells. | Cardiovascular research 20010101 |
| Systemic and portal hemodynamic effects of anandamide. | American journal of physiology. Gastrointestinal and liver physiology 20010101 |
| Carcinogen substrate specificity of human COX-1 and COX-2. | Carcinogenesis 20010101 |
| Different intracellular signals coupled to the antiproliferative action of aqueous crude extract from Larrea divaricata Cav. and nor-dihydroguaiaretic acid on a lymphoma cell line. | Phytomedicine : international journal of phytotherapy and phytopharmacology 20010101 |
| [Effect of inhibitors of cyclooxygenase and lipoxygenase pathways of arachidonic acid oxidation on the immune response and the activity of the monoxygenase system and lipid peroxidation in the spleen and liver in mice]. | Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20010101 |
| [Growth inhibition and induction of tumor cell death by phospholipase A2 and lipoxygenase inhibitors]. | Izvestiia Akademii nauk. Seriia biologicheskaia 20010101 |
| Protective effect of a lipoxygenase inhibitor, nordihydroguaretic acid, on the ileal motor disturbances induced by Serratia marcescens endotoxin in rats. | Surgery today 20010101 |
| Reduction in primary nonfunction of syngeneic islet transplants with nordihydroguaiaretic acid, a lipoxygenase inhibitor. | Cell transplantation 20010101 |
| Effects of 1alpha,25-(OH)(2)D(3) on rat growth zone chondrocytes are mediated via cyclooxygenase-1 and phospholipase A(2). | Journal of cellular biochemistry. Supplement 20010101 |
| Effect of nordihydroguaiaretic acid on behavioral impairment and neuronal cell death after forebrain ischemia. | Pharmacology, biochemistry, and behavior 20010101 |
| The role of eicosanoids in the process of adaptation following massive bowel resection in the rat. | JPEN. Journal of parenteral and enteral nutrition 20010101 |
| Low-density lipoprotein induced actin cytoskeleton reorganization in endothelial cells: mechanisms of action. | Endothelium : journal of endothelial cell research 20010101 |
| [Features of lipoxygenase from cells of Mortierella species mushrooms]. | Prikladnaia biokhimiia i mikrobiologiia 20010101 |
| 24R,25-(OH)(2)D(3) mediates its membrane receptor-dependent effects on protein kinase C and alkaline phosphatase via phospholipase A(2) and cyclooxygenase-1 but not cyclooxygenase-2 in growth plate chondrocytes. | Journal of cellular physiology 20000301 |
| Glutathione oxidation and mitochondrial depolarization as mechanisms of nordihydroguaiaretic acid-induced apoptosis in lipoxygenase-deficient FL5.12 cells. | Toxicological sciences : an official journal of the Society of Toxicology 20000101 |
| Prostaglandins and leukotriene B4 are potent inhibitors of 11beta-hydroxysteroid dehydrogenase type 2 activity in human choriocarcinoma JEG-3 cells. | Biology of reproduction 19990701 |
| Nordihydroguaiaretic acid blocks secretory and endocytic pathways in human dendritic cells. | Journal of leukocyte biology 19981201 |
| Crm-A, bcl-2 and NDGA inhibit CD95L-induced apoptosis of malignant glioma cells at the level of caspase 8 processing. | Cell death and differentiation 19981001 |
| Antiviral activities of methylated nordihydroguaiaretic acids. 1. Synthesis, structure identification, and inhibition of tat-regulated HIV transactivation. | Journal of medicinal chemistry 19980730 |
| Antiviral activities of methylated nordihydroguaiaretic acids. 2. Targeting herpes simplex virus replication by the mutation insensitive transcription inhibitor tetra-O-methyl-NDGA. | Journal of medicinal chemistry 19980730 |
| Apoptosis of W256 carcinosarcoma cells of the monocytoid origin induced by NDGA involves lipid peroxidation and depletion of GSH: role of 12-lipoxygenase in regulating tumor cell survival. | Journal of cellular physiology 19970801 |
| Enhancement of stress-induced synthesis of hsp27 and alpha B crystallin by modulators of the arachidonic acid cascade. | Journal of cellular physiology 19960201 |
| Inhibition of human immunodeficiency virus type 1 transcription and replication by DNA sequence-selective plant lignans. | Proceedings of the National Academy of Sciences of the United States of America 19951121 |
| Novel bishydroxamic acids as 5-lipoxygenase inhibitors. | Bioorganic & medicinal chemistry 19940301 |
| Effect of indomethacin, aspirin, nordihydroguairetic acid, and piperonyl butoxide on cyclophosphamide-induced bladder damage. | Drug and chemical toxicology 19930101 |
| Pharmacological investigation of the role of leukotrienes in the pathogenesis of experimental NSAID gastropathy. | Inflammation 19920601 |
| Arachidonic acid-induced calcium influx in human platelets. Comparison with the effect of thrombin. | The Biochemical journal 19901201 |
| Inhibition of benzoyl peroxide-mediated tumor promotion in 7,12-dimethylbenz(a)anthracene-initiated skin of Sencar mice by antioxidants nordihydroguaiaretic acid and diallyl sulfide. | The Journal of investigative dermatology 19900201 |
| Simple procedure for measuring the pharmacodynamics and analgesic potential of lipoxygenase inhibitors. | Journal of pharmacological methods 19881201 |
| Prolactin-dependent mitogenesis in Nb 2 node lymphoma cells: effects of immunosuppressive cyclopeptides. | Journal of immunology (Baltimore, Md. : 1950) 19870101 |
| Comparative effects of etodolac, indomethacin, and benoxaprofen on icosanoid biosynthesis. | Inflammation 19841201 |
| Inhibition of steroid production in Leydig cells by non-steroidal anti-inflammatory and related compounds: evidence for the involvement of lipoxygenase products in steroidogenesis. | The Biochemical journal 19840415 |
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