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CAS No: 2761-09-3 Catalog No: AG002U83 MDL No:MFCD00051317
Title | Journal |
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Dual fluorescent HPMA copolymers for passive tumor targeting with pH-sensitive drug release: synthesis and characterization of distribution and tumor accumulation in mice by noninvasive multispectral optical imaging. | Biomacromolecules 20120312 |
Biological activity of anti-CD20 multivalent HPMA copolymer-Fab' conjugates. | Biomacromolecules 20120312 |
Treatment of prostate carcinoma with (galectin-3)-targeted HPMA copolymer-(G3-C12)-5-Fluorouracil conjugates. | Biomaterials 20120301 |
Multifunctional pH-disintegrable micellar nanoparticles of asymmetrically functionalized β-cyclodextrin-based star copolymer covalently conjugated with doxorubicin and DOTA-Gd moieties. | Biomaterials 20120301 |
Synthesis and in vitro anti-tumor activity of novel HPMA copolymer-drug conjugates with potential cell surface targeting property for carcinoma cells. | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20120201 |
Selective inhibitory effect of HPMA copolymer-cyclopamine conjugate on prostate cancer stem cells. | Biomaterials 20120201 |
Enhancing the therapeutic efficacy of adenovirus in combination with biomaterials. | Biomaterials 20120201 |
Synthesis and characterization of biodegradable and thermosensitive polymeric micelles with covalently bound doxorubicin-glucuronide prodrug via click chemistry. | Bioconjugate chemistry 20111221 |
Biodegradable star HPMA polymer-drug conjugates: Biodegradability, distribution and anti-tumor efficacy. | Journal of controlled release : official journal of the Controlled Release Society 20110925 |
Conformational consequences of cooperative binding of a coiled-coil peptide motif to poly(N-(2-hydroxypropyl) methacrylamide) HPMA copolymers. | Journal of controlled release : official journal of the Controlled Release Society 20110730 |
Modifying the body distribution of HPMA-based copolymers by molecular weight and aggregate formation. | Biomacromolecules 20110711 |
HPMA based amphiphilic copolymers mediate central nervous effects of domperidone. | Macromolecular rapid communications 20110518 |
Effect of film thickness on the antifouling performance of poly(hydroxy-functional methacrylates) grafted surfaces. | Langmuir : the ACS journal of surfaces and colloids 20110419 |
Biodegradable star HPMA polymer conjugates of doxorubicin for passive tumor targeting. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20110418 |
Coupling to polymeric scaffolds stabilizes biofunctional peptides for intracellular applications. | Molecular pharmacology 20110401 |
Light induced drug delivery into cancer cells. | Biomaterials 20110201 |
Comparative biodistribution of PAMAM dendrimers and HPMA copolymers in ovarian-tumor-bearing mice. | Biomacromolecules 20110110 |
Immobilization of chloroperoxidase onto highly hydrophilic polyethylene chains via bio-conjugation: catalytic properties and stabilities. | Bioresource technology 20110101 |
Sphingosine-1-phosphate promotes the differentiation of human umbilical cord mesenchymal stem cells into cardiomyocytes under the designated culturing conditions. | Journal of biomedical science 20110101 |
Achieving highly effective nonfouling performance for surface-grafted poly(HPMA) via atom-transfer radical polymerization. | Langmuir : the ACS journal of surfaces and colloids 20101116 |
HPMA-RGD hydrogels seeded with mesenchymal stem cells improve functional outcome in chronic spinal cord injury. | Stem cells and development 20101001 |
Synthesis and in vitro evaluation of defined HPMA folate conjugates: influence of aggregation on folate receptor (FR) mediated cellular uptake. | Biomacromolecules 20100913 |
HPMA copolymer conjugates of paclitaxel and docetaxel with pH-controlled drug release. | Molecular pharmaceutics 20100802 |
Synthesis, characterization and enhanced photoconductivity from a mesoporous titania on dye doping. | Analytica chimica acta 20100726 |
Functional diversification of AGAMOUS lineage genes in regulating tomato flower and fruit development. | Journal of experimental botany 20100601 |
Langmuir-Blodgett films of biocompatible poly(HPMA)-block-poly(lauryl methacrylate) and poly(HPMA)-random-poly(lauryl methacrylate): influence of polymer structure on membrane formation and stability. | Langmuir : the ACS journal of surfaces and colloids 20100420 |
Water-soluble polymer-drug conjugates for combination chemotherapy against visceral leishmaniasis. | Bioorganic & medicinal chemistry 20100401 |
Chemical conjugation of cowpea mosaic viruses with reactive HPMA-based polymers. | Journal of biomaterials science. Polymer edition 20100101 |
Development of a macromolecular prodrug for the treatment of inflammatory arthritis: mechanisms involved in arthrotropism and sustained therapeutic efficacy. | Arthritis research & therapy 20100101 |
HPMA copolymer conjugates with reduced anti-CD20 antibody for cell-specific drug targeting. I. Synthesis and in vitro evaluation of binding efficacy and cytostatic activity. | Journal of controlled release : official journal of the Controlled Release Society 20091116 |
Hyperbranched polyamidoamines containing beta-cyclodextrin for controlled release of chlorambucil. | Macromolecular bioscience 20091110 |
Antitumor efficacy of colon-specific HPMA copolymer/9-aminocamptothecin conjugates in mice bearing human-colon carcinoma xenografts. | Macromolecular bioscience 20091110 |
Synthesis and bioactivity of poly(HPMA)-lysozyme conjugates: the use of novel thiazolidine-2-thione coupling chemistry. | Organic & biomolecular chemistry 20090907 |
Nortriptyline for smoking cessation: release and human skin diffusion from patches. | International journal of pharmaceutics 20090813 |
Evaluation of pharmacokinetics of bioreducible gene delivery vectors by real-time PCR. | Pharmaceutical research 20090701 |
HPMA-based polymer conjugates with drug combination. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20090628 |
N-(2-hydroxypropyl)methacrylamide-amphotericin B (HPMA-AmB) copolymer conjugates as antileishmanial agents. | International journal of antimicrobial agents 20090501 |
Cetuximab retargeting of adenovirus via the epidermal growth factor receptor for treatment of intraperitoneal ovarian cancer. | Human gene therapy 20090301 |
Self-assembling diblock copolymers of poly[N-(2-hydroxypropyl)methacrylamide] and a beta-sheet peptide. | Macromolecular bioscience 20090109 |
Biorecognition and subcellular trafficking of HPMA copolymer-anti-PSMA antibody conjugates by prostate cancer cells. | Molecular pharmaceutics 20090101 |
Synthesis and evaluation of a well-defined HPMA copolymer-dexamethasone conjugate for effective treatment of rheumatoid arthritis. | Pharmaceutical research 20081201 |
Feasibility of using a bone-targeted, macromolecular delivery system coupled with prostaglandin E(1) to promote bone formation in aged, estrogen-deficient rats. | Pharmaceutical research 20081201 |
One-pot conversion of RAFT-generated multifunctional block copolymers of HPMA to doxorubicin conjugated acid- and reductant-sensitive crosslinked micelles. | Biomacromolecules 20081101 |
From defined reactive diblock copolymers to functional HPMA-based self-assembled nanoaggregates. | Biomacromolecules 20081101 |
HPMA copolymer-doxorubicin-gadolinium conjugates: synthesis, characterization, and in vitro evaluation. | Macromolecular bioscience 20080811 |
Synthesis and biological evaluation of disulfide-linked HPMA copolymer-mesochlorin e6 conjugates. | Macromolecular bioscience 20080513 |
New HPMA copolymer-based drug carriers with covalently bound hydrophobic substituents for solid tumour targeting. | Journal of controlled release : official journal of the Controlled Release Society 20080421 |
Doxorubicin release is not a prerequisite for the in vitro cytotoxicity of HPMA-based pharmaceuticals: in vitro effect of extra drug-free GlyPheLeuGly sequences. | Journal of controlled release : official journal of the Controlled Release Society 20080421 |
Enhanced antitumor activity of combinations of free and HPMA copolymer-bound drugs. | International journal of pharmaceutics 20080303 |
Dynamic light scattering study of self-assembly of HPMA hybrid graft copolymers. | Biomacromolecules 20080201 |
Pharmacokinetic modeling of absorption behavior of 9-aminocamptothecin (9-AC) released from colon-specific HPMA copolymer-9-AC conjugate in rats. | Pharmaceutical research 20080101 |
Biodegradable, cationic methacrylamide-based polymers for gene delivery to ovarian cancer cells in mice. | Molecular pharmaceutics 20080101 |
Campylobacter jejuni survives within epithelial cells by avoiding delivery to lysosomes. | PLoS pathogens 20080101 |
Stability in plasmas of various species of HPMA copolymer-PGE1 conjugates. | Pharmaceutical research 20071201 |
[Pilot study of a cell membrane like biomimetic drug-eluting coronary stent]. | Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20070601 |
Effect of radiotherapy and hyperthermia on the tumor accumulation of HPMA copolymer-based drug delivery systems. | Journal of controlled release : official journal of the Controlled Release Society 20070226 |
Biodistribution and pharmacokinetics of colon-specific HPMA copolymer--9-aminocamptothecin conjugate in mice. | Journal of controlled release : official journal of the Controlled Release Society 20070212 |
Designing polymer conjugates as lysosomotropic nanomedicines. | Biochemical Society transactions 20070201 |
Novel dexamethasone-HPMA copolymer conjugate and its potential application in treatment of rheumatoid arthritis. | Arthritis research & therapy 20070101 |
Affinity separation of immunoglobulin G subclasses on dye attached poly(hydroxypropyl methacrylate) beads. | International journal of biological macromolecules 20061115 |
Properties of HPMA copolymer-doxorubicin conjugates with pH-controlled activation: effect of polymer chain modification. | Journal of controlled release : official journal of the Controlled Release Society 20060928 |
Polymeric conjugates of mono- and bi-cyclic alphaVbeta3 binding peptides for tumor targeting. | Journal of controlled release : official journal of the Controlled Release Society 20060828 |
Enhancement of ethyl propionate synthesis by poly (AAc-co-HPMA-cl-MBAm)-immobilized Pseudomonas aeruginosa MTCC-4713, exposed to Hg2+ and NH4+ ions. | Acta microbiologica et immunologica Hungarica 20060601 |
Hybrid hydrogels self-assembled from HPMA copolymers containing peptide grafts. | Macromolecular bioscience 20060314 |
Colon-specific 9-aminocamptothecin-HPMA copolymer conjugates containing a 1,6-elimination spacer. | Journal of controlled release : official journal of the Controlled Release Society 20060110 |
Polymer-peptide conjugates for angiogenesis targeted tumor radiotherapy. | Nuclear medicine and biology 20060101 |
Macrophage targeted N-(2-hydroxypropyl)methacrylamide conjugates for magnetic resonance imaging. | Molecular pharmaceutics 20060101 |
Effect of physicochemical modification on the biodistribution and tumor accumulation of HPMA copolymers. | Journal of controlled release : official journal of the Controlled Release Society 20051210 |
Ultrasound-enhanced transfection activity of HPMA-stabilized DNA polyplexes with prolonged plasma circulation. | Journal of controlled release : official journal of the Controlled Release Society 20050902 |
Targeting tumor angiogenesis: comparison of peptide and polymer-peptide conjugates. | Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20050901 |
Induction of systemic antitumour resistance with targeted polymers. | Scandinavian journal of immunology 20050701 |
Polymer therapeutics designed for a combination therapy of hormone-dependent cancer. | Angewandte Chemie (International ed. in English) 20050627 |
Water-soluble polymers for targeted drug delivery to human squamous carcinoma of head and neck. | Journal of drug targeting 20050401 |
Intracellular targeting of polymer-bound drugs for cancer chemotherapy. | Advanced drug delivery reviews 20050227 |
Improved preservation of X-gal reaction product for electron microscopy using hydroxypropyl methacrylate. | Neuroscience letters 20050201 |
Oligopeptides as targeting structures in cancer theraPY. | Journal of controlled release : official journal of the Controlled Release Society 20050103 |
Final report of the safety assessment of methacrylate ester monomers used in nail enhancement products. | International journal of toxicology 20050101 |
Vitamin-mediated targeting as a potential mechanism to increase drug uptake by tumours. | Journal of inorganic biochemistry 20041001 |
The arthrotropism of macromolecules in adjuvant-induced arthritis rat model: a preliminary study. | Pharmaceutical research 20041001 |
Aggregation properties of a HPMA-camptothecin copolymer in isotonic solutions. | Biophysical chemistry 20040801 |
The effect of the processing and formulation parameters on the size of nanoparticles based on block copolymers of poly(ethylene glycol) and poly(N-isopropylacrylamide) with and without hydrolytically sensitive groups. | Biomaterials 20040501 |
Targeting angiogenesis with a conjugate of HPMA copolymer and TNP-470. | Nature medicine 20040301 |
Polymer-conjugated bovine pancreatic and seminal ribonucleases inhibit growth of human tumors in nude mice. | Journal of controlled release : official journal of the Controlled Release Society 20040220 |
Polymer therapeutics - Sixth International Symposium: from laboratory to clinical practice. | IDrugs : the investigational drugs journal 20040201 |
A novel crosslinkable polymer as drug-loaded coating for biomedical device. | Journal of materials science. Materials in medicine 20040201 |
Prevention of gliotic scar formation by NeuroGel allows partial endogenous repair of transected cat spinal cord. | Journal of neuroscience research 20040115 |
HPMA copolymer-1,5-diazaanthraquinone conjugates as novel anticancer therapeutics. | Journal of drug targeting 20040101 |
Starlike vs. classic macromolecular prodrugs: two different antibody-targeted HPMA copolymers of doxorubicin studied in vitro and in vivo as potential anticancer drugs. | Pharmaceutical research 20031001 |
[Synthesis and characterization of biomacromolecular conjugates for magnetic resonance imaging]. | Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20030901 |
Cytostatic and immunomobilizing activities of polymer-bound drugs: experimental and first clinical data. | Journal of controlled release : official journal of the Controlled Release Society 20030828 |
Subcellular trafficking of HPMA copolymer-Tat conjugates in human ovarian carcinoma cells. | Journal of controlled release : official journal of the Controlled Release Society 20030828 |
Mechanisms of cytotoxicity in human ovarian carcinoma cells exposed to free Mce6 or HPMA copolymer-Mce6 conjugates. | Photochemistry and photobiology 20030601 |
Correlation of subcellular compartmentalization of HPMA copolymer-Mce6 conjugates with chemotherapeutic activity in human ovarian carcinoma cells. | Pharmaceutical research 20030501 |
HPMA copolymers with pH-controlled release of doxorubicin: in vitro cytotoxicity and in vivo antitumor activity. | Journal of controlled release : official journal of the Controlled Release Society 20030221 |
Tat-conjugated synthetic macromolecules facilitate cytoplasmic drug delivery to human ovarian carcinoma cells. | Bioconjugate chemistry 20030101 |
HPMA copolymer delivery of chemotherapy and photodynamic therapy in ovarian cancer. | Advances in experimental medicine and biology 20030101 |
PDEPT: polymer-directed enzyme prodrug therapy. 2. HPMA copolymer-beta-lactamase and HPMA copolymer-C-Dox as a model combination. | Bioconjugate chemistry 20030101 |
Polyacetal-doxorubicin conjugates designed for pH-dependent degradation. | Bioconjugate chemistry 20030101 |
HPMA copolymers platinates containing dicarboxylato ligands. Preparation, characterisation and in vitro and in vivo evaluation. | Journal of drug targeting 20021101 |
Synthesis of hydroxypropyl methacrylate/polysaccharide graft copolymers as matrices for controlled release tablets. | Drug development and industrial pharmacy 20021001 |
Immunomodulating activities of soluble synthetic polymer-bound drugs. | Advanced drug delivery reviews 20020913 |
Synthesis and characterization of a catalytic antibody-HPMA copolymer-Conjugate as a tool for tumor selective prodrug activation. | Bioorganic & medicinal chemistry 20020901 |
The role of galactose, lactose, and galactose valency in the biorecognition of N-(2-hydroxypropyl)methacrylamide copolymers by human colon adenocarcinoma cells. | Pharmaceutical research 20020801 |
HPMA-hydrogels containing cytostatic drugs. Kinetics of the drug release and in vivo efficacy. | Journal of controlled release : official journal of the Controlled Release Society 20020517 |
Targeted delivery of doxorubicin by HPMA copolymer-hyaluronan bioconjugates. | Pharmaceutical research 20020401 |
In vitro and in vivo effect of HPMA copolymer-bound doxorubicin targeted to transferrin receptor of B-cell lymphoma 38C13. | Journal of drug targeting 20020201 |
Acquired and specific immunological mechanisms co-responsible for efficacy of polymer-bound drugs. | Journal of controlled release : official journal of the Controlled Release Society 20020117 |
Design of novel bioconjugates for targeted drug delivery. | Journal of controlled release : official journal of the Controlled Release Society 20020117 |
Star structure of antibody-targeted HPMA copolymer-bound doxorubicin: a novel type of polymeric conjugate for targeted drug delivery with potent antitumor effect. | Bioconjugate chemistry 20020101 |
Antisense oligonucleotides delivered to the lysosome escape and actively inhibit the hepatitis B virus. | Bioconjugate chemistry 20020101 |
Use of hydrophilic hydroxypropyl methacrylate/ethylene glycol methacrylate packing material in size-exclusion chromatography. | Journal of AOAC International 20020101 |
N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers for targeted delivery of 8-aminoquinoline antileishmanial drugs. | Journal of controlled release : official journal of the Controlled Release Society 20011213 |
Biorecognizable HPMA copolymer-drug conjugates for colon-specific delivery of 9-aminocamptothecin. | Journal of controlled release : official journal of the Controlled Release Society 20010810 |
Polymer-drug conjugates, PDEPT and PELT: basic principles for design and transfer from the laboratory to clinic. | Journal of controlled release : official journal of the Controlled Release Society 20010706 |
Synthesis and characterization of HPMA copolymer-aminopropylgeldanamycin conjugates. | Journal of controlled release : official journal of the Controlled Release Society 20010706 |
Doxorubicin bound to a HPMA copolymer carrier through hydrazone bond is effective also in a cancer cell line with a limited content of lysosomes. | Journal of controlled release : official journal of the Controlled Release Society 20010706 |
Combination chemotherapy and photodynamic therapy of targetable N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin/mesochlorin e(6)-OV-TL 16 antibody immunoconjugates. | Journal of controlled release : official journal of the Controlled Release Society 20010706 |
Preparation and biological evaluation of polymerizable antibody Fab' fragment targeted polymeric drug delivery system. | Journal of controlled release : official journal of the Controlled Release Society 20010706 |
The effects of subcellular localization of N-(2-hydroxypropyl)methacrylamide copolymer-Mce(6) conjugates in a human ovarian carcinoma. | Journal of controlled release : official journal of the Controlled Release Society 20010706 |
Water-soluble HPMA copolymer-wortmannin conjugate retains phosphoinositide 3-kinase inhibitory activity in vitro and in vivo. | Journal of controlled release : official journal of the Controlled Release Society 20010706 |
Potential of lectin-N-(2-hydroxypropyl)methacrylamide copolymer-drug conjugates for the treatment of pre-cancerous conditions. | Journal of controlled release : official journal of the Controlled Release Society 20010706 |
New HPMA copolymers containing doxorubicin bound via pH-sensitive linkage: synthesis and preliminary in vitro and in vivo biological properties. | Journal of controlled release : official journal of the Controlled Release Society 20010518 |
Preliminary evaluation of caspases-dependent apoptosis signaling pathways of free and HPMA copolymer-bound doxorubicin in human ovarian carcinoma cells. | Journal of controlled release : official journal of the Controlled Release Society 20010428 |
Phase I clinical and pharmacokinetic study of PNU166945, a novel water-soluble polymer-conjugated prodrug of paclitaxel. | Anti-cancer drugs 20010401 |
The influence of a colonic microbiota on HPMA copolymer lectin conjugates binding in rodent intestine. | Journal of drug targeting 20010401 |
Polymer-coated adenovirus permits efficient retargeting and evades neutralising antibodies. | Gene therapy 20010301 |
[Study of 'living' radical polymerization by FTIR in situ]. | Guang pu xue yu guang pu fen xi = Guang pu 20010201 |
The effect of two hydrophilic monomers on the water uptake of a heterocyclic methacrylate system. | Biomaterials 20010101 |
Crosslinkable coatings from phosphorylcholine-based polymers. | Biomaterials 20010101 |
Modification of cyclosporin A and conjugation of its derivative to HPMA copolymers. | Bioconjugate chemistry 20010101 |
Synthetic macromolecular drug carriers: biodistribution of poly[(N-2-hydroxypropyl)methacrylamide] copolymers and their accumulation in solid rat tumors. | PDA journal of pharmaceutical science and technology 20010101 |
N-(2-hydroxypropyl)methacrylamide copolymer-6-(3-aminopropyl)-ellipticine conjugates. Synthesis, in vitro, and preliminary in vivo evaluation. | Bioconjugate chemistry 20010101 |
Enhanced biorecognition and internalization of HPMA copolymers containing multiple or multivalent carbohydrate side-chains by human hepatocarcinoma cells. | Bioconjugate chemistry 20010101 |
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