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2761-09-3

2761-09-3 | 2-Propenoic acid, 2-methyl-, 3-hydroxypropyl ester

CAS No: 2761-09-3 Catalog No: AG002U83 MDL No:MFCD00051317

Product Description

Catalog Number:
AG002U83
Chemical Name:
2-Propenoic acid, 2-methyl-, 3-hydroxypropyl ester
CAS Number:
2761-09-3
Molecular Formula:
C7H12O3
Molecular Weight:
144.1684
MDL Number:
MFCD00051317
IUPAC Name:
3-hydroxypropyl 2-methylprop-2-enoate
InChI:
InChI=1S/C7H12O3/c1-6(2)7(9)10-5-3-4-8/h8H,1,3-5H2,2H3
InChI Key:
GNSFRPWPOGYVLO-UHFFFAOYSA-N
SMILES:
CC(=C)C(=O)OCCCO
EC Number:
220-426-2
UNII:
523A6318HJ

Properties

Complexity:
129  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
144.079g/mol
Formal Charge:
0
Heavy Atom Count:
10  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
144.17g/mol
Monoisotopic Mass:
144.079g/mol
Rotatable Bond Count:
5  
Topological Polar Surface Area:
46.5A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.3  

Literature

Title Journal
Dual fluorescent HPMA copolymers for passive tumor targeting with pH-sensitive drug release: synthesis and characterization of distribution and tumor accumulation in mice by noninvasive multispectral optical imaging. Biomacromolecules 20120312
Biological activity of anti-CD20 multivalent HPMA copolymer-Fab' conjugates. Biomacromolecules 20120312
Treatment of prostate carcinoma with (galectin-3)-targeted HPMA copolymer-(G3-C12)-5-Fluorouracil conjugates. Biomaterials 20120301
Multifunctional pH-disintegrable micellar nanoparticles of asymmetrically functionalized β-cyclodextrin-based star copolymer covalently conjugated with doxorubicin and DOTA-Gd moieties. Biomaterials 20120301
Synthesis and in vitro anti-tumor activity of novel HPMA copolymer-drug conjugates with potential cell surface targeting property for carcinoma cells. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20120201
Selective inhibitory effect of HPMA copolymer-cyclopamine conjugate on prostate cancer stem cells. Biomaterials 20120201
Enhancing the therapeutic efficacy of adenovirus in combination with biomaterials. Biomaterials 20120201
Synthesis and characterization of biodegradable and thermosensitive polymeric micelles with covalently bound doxorubicin-glucuronide prodrug via click chemistry. Bioconjugate chemistry 20111221
Biodegradable star HPMA polymer-drug conjugates: Biodegradability, distribution and anti-tumor efficacy. Journal of controlled release : official journal of the Controlled Release Society 20110925
Conformational consequences of cooperative binding of a coiled-coil peptide motif to poly(N-(2-hydroxypropyl) methacrylamide) HPMA copolymers. Journal of controlled release : official journal of the Controlled Release Society 20110730
Modifying the body distribution of HPMA-based copolymers by molecular weight and aggregate formation. Biomacromolecules 20110711
HPMA based amphiphilic copolymers mediate central nervous effects of domperidone. Macromolecular rapid communications 20110518
Effect of film thickness on the antifouling performance of poly(hydroxy-functional methacrylates) grafted surfaces. Langmuir : the ACS journal of surfaces and colloids 20110419
Biodegradable star HPMA polymer conjugates of doxorubicin for passive tumor targeting. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20110418
Coupling to polymeric scaffolds stabilizes biofunctional peptides for intracellular applications. Molecular pharmacology 20110401
Light induced drug delivery into cancer cells. Biomaterials 20110201
Comparative biodistribution of PAMAM dendrimers and HPMA copolymers in ovarian-tumor-bearing mice. Biomacromolecules 20110110
Immobilization of chloroperoxidase onto highly hydrophilic polyethylene chains via bio-conjugation: catalytic properties and stabilities. Bioresource technology 20110101
Sphingosine-1-phosphate promotes the differentiation of human umbilical cord mesenchymal stem cells into cardiomyocytes under the designated culturing conditions. Journal of biomedical science 20110101
Achieving highly effective nonfouling performance for surface-grafted poly(HPMA) via atom-transfer radical polymerization. Langmuir : the ACS journal of surfaces and colloids 20101116
HPMA-RGD hydrogels seeded with mesenchymal stem cells improve functional outcome in chronic spinal cord injury. Stem cells and development 20101001
Synthesis and in vitro evaluation of defined HPMA folate conjugates: influence of aggregation on folate receptor (FR) mediated cellular uptake. Biomacromolecules 20100913
HPMA copolymer conjugates of paclitaxel and docetaxel with pH-controlled drug release. Molecular pharmaceutics 20100802
Synthesis, characterization and enhanced photoconductivity from a mesoporous titania on dye doping. Analytica chimica acta 20100726
Functional diversification of AGAMOUS lineage genes in regulating tomato flower and fruit development. Journal of experimental botany 20100601
Langmuir-Blodgett films of biocompatible poly(HPMA)-block-poly(lauryl methacrylate) and poly(HPMA)-random-poly(lauryl methacrylate): influence of polymer structure on membrane formation and stability. Langmuir : the ACS journal of surfaces and colloids 20100420
Water-soluble polymer-drug conjugates for combination chemotherapy against visceral leishmaniasis. Bioorganic & medicinal chemistry 20100401
Chemical conjugation of cowpea mosaic viruses with reactive HPMA-based polymers. Journal of biomaterials science. Polymer edition 20100101
Development of a macromolecular prodrug for the treatment of inflammatory arthritis: mechanisms involved in arthrotropism and sustained therapeutic efficacy. Arthritis research & therapy 20100101
HPMA copolymer conjugates with reduced anti-CD20 antibody for cell-specific drug targeting. I. Synthesis and in vitro evaluation of binding efficacy and cytostatic activity. Journal of controlled release : official journal of the Controlled Release Society 20091116
Hyperbranched polyamidoamines containing beta-cyclodextrin for controlled release of chlorambucil. Macromolecular bioscience 20091110
Antitumor efficacy of colon-specific HPMA copolymer/9-aminocamptothecin conjugates in mice bearing human-colon carcinoma xenografts. Macromolecular bioscience 20091110
Synthesis and bioactivity of poly(HPMA)-lysozyme conjugates: the use of novel thiazolidine-2-thione coupling chemistry. Organic & biomolecular chemistry 20090907
Nortriptyline for smoking cessation: release and human skin diffusion from patches. International journal of pharmaceutics 20090813
Evaluation of pharmacokinetics of bioreducible gene delivery vectors by real-time PCR. Pharmaceutical research 20090701
HPMA-based polymer conjugates with drug combination. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20090628
N-(2-hydroxypropyl)methacrylamide-amphotericin B (HPMA-AmB) copolymer conjugates as antileishmanial agents. International journal of antimicrobial agents 20090501
Cetuximab retargeting of adenovirus via the epidermal growth factor receptor for treatment of intraperitoneal ovarian cancer. Human gene therapy 20090301
Self-assembling diblock copolymers of poly[N-(2-hydroxypropyl)methacrylamide] and a beta-sheet peptide. Macromolecular bioscience 20090109
Biorecognition and subcellular trafficking of HPMA copolymer-anti-PSMA antibody conjugates by prostate cancer cells. Molecular pharmaceutics 20090101
Synthesis and evaluation of a well-defined HPMA copolymer-dexamethasone conjugate for effective treatment of rheumatoid arthritis. Pharmaceutical research 20081201
Feasibility of using a bone-targeted, macromolecular delivery system coupled with prostaglandin E(1) to promote bone formation in aged, estrogen-deficient rats. Pharmaceutical research 20081201
One-pot conversion of RAFT-generated multifunctional block copolymers of HPMA to doxorubicin conjugated acid- and reductant-sensitive crosslinked micelles. Biomacromolecules 20081101
From defined reactive diblock copolymers to functional HPMA-based self-assembled nanoaggregates. Biomacromolecules 20081101
HPMA copolymer-doxorubicin-gadolinium conjugates: synthesis, characterization, and in vitro evaluation. Macromolecular bioscience 20080811
Synthesis and biological evaluation of disulfide-linked HPMA copolymer-mesochlorin e6 conjugates. Macromolecular bioscience 20080513
New HPMA copolymer-based drug carriers with covalently bound hydrophobic substituents for solid tumour targeting. Journal of controlled release : official journal of the Controlled Release Society 20080421
Doxorubicin release is not a prerequisite for the in vitro cytotoxicity of HPMA-based pharmaceuticals: in vitro effect of extra drug-free GlyPheLeuGly sequences. Journal of controlled release : official journal of the Controlled Release Society 20080421
Enhanced antitumor activity of combinations of free and HPMA copolymer-bound drugs. International journal of pharmaceutics 20080303
Dynamic light scattering study of self-assembly of HPMA hybrid graft copolymers. Biomacromolecules 20080201
Pharmacokinetic modeling of absorption behavior of 9-aminocamptothecin (9-AC) released from colon-specific HPMA copolymer-9-AC conjugate in rats. Pharmaceutical research 20080101
Biodegradable, cationic methacrylamide-based polymers for gene delivery to ovarian cancer cells in mice. Molecular pharmaceutics 20080101
Campylobacter jejuni survives within epithelial cells by avoiding delivery to lysosomes. PLoS pathogens 20080101
Stability in plasmas of various species of HPMA copolymer-PGE1 conjugates. Pharmaceutical research 20071201
[Pilot study of a cell membrane like biomimetic drug-eluting coronary stent]. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20070601
Effect of radiotherapy and hyperthermia on the tumor accumulation of HPMA copolymer-based drug delivery systems. Journal of controlled release : official journal of the Controlled Release Society 20070226
Biodistribution and pharmacokinetics of colon-specific HPMA copolymer--9-aminocamptothecin conjugate in mice. Journal of controlled release : official journal of the Controlled Release Society 20070212
Designing polymer conjugates as lysosomotropic nanomedicines. Biochemical Society transactions 20070201
Novel dexamethasone-HPMA copolymer conjugate and its potential application in treatment of rheumatoid arthritis. Arthritis research & therapy 20070101
Affinity separation of immunoglobulin G subclasses on dye attached poly(hydroxypropyl methacrylate) beads. International journal of biological macromolecules 20061115
Properties of HPMA copolymer-doxorubicin conjugates with pH-controlled activation: effect of polymer chain modification. Journal of controlled release : official journal of the Controlled Release Society 20060928
Polymeric conjugates of mono- and bi-cyclic alphaVbeta3 binding peptides for tumor targeting. Journal of controlled release : official journal of the Controlled Release Society 20060828
Enhancement of ethyl propionate synthesis by poly (AAc-co-HPMA-cl-MBAm)-immobilized Pseudomonas aeruginosa MTCC-4713, exposed to Hg2+ and NH4+ ions. Acta microbiologica et immunologica Hungarica 20060601
Hybrid hydrogels self-assembled from HPMA copolymers containing peptide grafts. Macromolecular bioscience 20060314
Colon-specific 9-aminocamptothecin-HPMA copolymer conjugates containing a 1,6-elimination spacer. Journal of controlled release : official journal of the Controlled Release Society 20060110
Polymer-peptide conjugates for angiogenesis targeted tumor radiotherapy. Nuclear medicine and biology 20060101
Macrophage targeted N-(2-hydroxypropyl)methacrylamide conjugates for magnetic resonance imaging. Molecular pharmaceutics 20060101
Effect of physicochemical modification on the biodistribution and tumor accumulation of HPMA copolymers. Journal of controlled release : official journal of the Controlled Release Society 20051210
Ultrasound-enhanced transfection activity of HPMA-stabilized DNA polyplexes with prolonged plasma circulation. Journal of controlled release : official journal of the Controlled Release Society 20050902
Targeting tumor angiogenesis: comparison of peptide and polymer-peptide conjugates. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20050901
Induction of systemic antitumour resistance with targeted polymers. Scandinavian journal of immunology 20050701
Polymer therapeutics designed for a combination therapy of hormone-dependent cancer. Angewandte Chemie (International ed. in English) 20050627
Water-soluble polymers for targeted drug delivery to human squamous carcinoma of head and neck. Journal of drug targeting 20050401
Intracellular targeting of polymer-bound drugs for cancer chemotherapy. Advanced drug delivery reviews 20050227
Improved preservation of X-gal reaction product for electron microscopy using hydroxypropyl methacrylate. Neuroscience letters 20050201
Oligopeptides as targeting structures in cancer theraPY. Journal of controlled release : official journal of the Controlled Release Society 20050103
Final report of the safety assessment of methacrylate ester monomers used in nail enhancement products. International journal of toxicology 20050101
Vitamin-mediated targeting as a potential mechanism to increase drug uptake by tumours. Journal of inorganic biochemistry 20041001
The arthrotropism of macromolecules in adjuvant-induced arthritis rat model: a preliminary study. Pharmaceutical research 20041001
Aggregation properties of a HPMA-camptothecin copolymer in isotonic solutions. Biophysical chemistry 20040801
The effect of the processing and formulation parameters on the size of nanoparticles based on block copolymers of poly(ethylene glycol) and poly(N-isopropylacrylamide) with and without hydrolytically sensitive groups. Biomaterials 20040501
Targeting angiogenesis with a conjugate of HPMA copolymer and TNP-470. Nature medicine 20040301
Polymer-conjugated bovine pancreatic and seminal ribonucleases inhibit growth of human tumors in nude mice. Journal of controlled release : official journal of the Controlled Release Society 20040220
Polymer therapeutics - Sixth International Symposium: from laboratory to clinical practice. IDrugs : the investigational drugs journal 20040201
A novel crosslinkable polymer as drug-loaded coating for biomedical device. Journal of materials science. Materials in medicine 20040201
Prevention of gliotic scar formation by NeuroGel allows partial endogenous repair of transected cat spinal cord. Journal of neuroscience research 20040115
HPMA copolymer-1,5-diazaanthraquinone conjugates as novel anticancer therapeutics. Journal of drug targeting 20040101
Starlike vs. classic macromolecular prodrugs: two different antibody-targeted HPMA copolymers of doxorubicin studied in vitro and in vivo as potential anticancer drugs. Pharmaceutical research 20031001
[Synthesis and characterization of biomacromolecular conjugates for magnetic resonance imaging]. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20030901
Cytostatic and immunomobilizing activities of polymer-bound drugs: experimental and first clinical data. Journal of controlled release : official journal of the Controlled Release Society 20030828
Subcellular trafficking of HPMA copolymer-Tat conjugates in human ovarian carcinoma cells. Journal of controlled release : official journal of the Controlled Release Society 20030828
Mechanisms of cytotoxicity in human ovarian carcinoma cells exposed to free Mce6 or HPMA copolymer-Mce6 conjugates. Photochemistry and photobiology 20030601
Correlation of subcellular compartmentalization of HPMA copolymer-Mce6 conjugates with chemotherapeutic activity in human ovarian carcinoma cells. Pharmaceutical research 20030501
HPMA copolymers with pH-controlled release of doxorubicin: in vitro cytotoxicity and in vivo antitumor activity. Journal of controlled release : official journal of the Controlled Release Society 20030221
Tat-conjugated synthetic macromolecules facilitate cytoplasmic drug delivery to human ovarian carcinoma cells. Bioconjugate chemistry 20030101
HPMA copolymer delivery of chemotherapy and photodynamic therapy in ovarian cancer. Advances in experimental medicine and biology 20030101
PDEPT: polymer-directed enzyme prodrug therapy. 2. HPMA copolymer-beta-lactamase and HPMA copolymer-C-Dox as a model combination. Bioconjugate chemistry 20030101
Polyacetal-doxorubicin conjugates designed for pH-dependent degradation. Bioconjugate chemistry 20030101
HPMA copolymers platinates containing dicarboxylato ligands. Preparation, characterisation and in vitro and in vivo evaluation. Journal of drug targeting 20021101
Synthesis of hydroxypropyl methacrylate/polysaccharide graft copolymers as matrices for controlled release tablets. Drug development and industrial pharmacy 20021001
Immunomodulating activities of soluble synthetic polymer-bound drugs. Advanced drug delivery reviews 20020913
Synthesis and characterization of a catalytic antibody-HPMA copolymer-Conjugate as a tool for tumor selective prodrug activation. Bioorganic & medicinal chemistry 20020901
The role of galactose, lactose, and galactose valency in the biorecognition of N-(2-hydroxypropyl)methacrylamide copolymers by human colon adenocarcinoma cells. Pharmaceutical research 20020801
HPMA-hydrogels containing cytostatic drugs. Kinetics of the drug release and in vivo efficacy. Journal of controlled release : official journal of the Controlled Release Society 20020517
Targeted delivery of doxorubicin by HPMA copolymer-hyaluronan bioconjugates. Pharmaceutical research 20020401
In vitro and in vivo effect of HPMA copolymer-bound doxorubicin targeted to transferrin receptor of B-cell lymphoma 38C13. Journal of drug targeting 20020201
Acquired and specific immunological mechanisms co-responsible for efficacy of polymer-bound drugs. Journal of controlled release : official journal of the Controlled Release Society 20020117
Design of novel bioconjugates for targeted drug delivery. Journal of controlled release : official journal of the Controlled Release Society 20020117
Star structure of antibody-targeted HPMA copolymer-bound doxorubicin: a novel type of polymeric conjugate for targeted drug delivery with potent antitumor effect. Bioconjugate chemistry 20020101
Antisense oligonucleotides delivered to the lysosome escape and actively inhibit the hepatitis B virus. Bioconjugate chemistry 20020101
Use of hydrophilic hydroxypropyl methacrylate/ethylene glycol methacrylate packing material in size-exclusion chromatography. Journal of AOAC International 20020101
N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers for targeted delivery of 8-aminoquinoline antileishmanial drugs. Journal of controlled release : official journal of the Controlled Release Society 20011213
Biorecognizable HPMA copolymer-drug conjugates for colon-specific delivery of 9-aminocamptothecin. Journal of controlled release : official journal of the Controlled Release Society 20010810
Polymer-drug conjugates, PDEPT and PELT: basic principles for design and transfer from the laboratory to clinic. Journal of controlled release : official journal of the Controlled Release Society 20010706
Synthesis and characterization of HPMA copolymer-aminopropylgeldanamycin conjugates. Journal of controlled release : official journal of the Controlled Release Society 20010706
Doxorubicin bound to a HPMA copolymer carrier through hydrazone bond is effective also in a cancer cell line with a limited content of lysosomes. Journal of controlled release : official journal of the Controlled Release Society 20010706
Combination chemotherapy and photodynamic therapy of targetable N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin/mesochlorin e(6)-OV-TL 16 antibody immunoconjugates. Journal of controlled release : official journal of the Controlled Release Society 20010706
Preparation and biological evaluation of polymerizable antibody Fab' fragment targeted polymeric drug delivery system. Journal of controlled release : official journal of the Controlled Release Society 20010706
The effects of subcellular localization of N-(2-hydroxypropyl)methacrylamide copolymer-Mce(6) conjugates in a human ovarian carcinoma. Journal of controlled release : official journal of the Controlled Release Society 20010706
Water-soluble HPMA copolymer-wortmannin conjugate retains phosphoinositide 3-kinase inhibitory activity in vitro and in vivo. Journal of controlled release : official journal of the Controlled Release Society 20010706
Potential of lectin-N-(2-hydroxypropyl)methacrylamide copolymer-drug conjugates for the treatment of pre-cancerous conditions. Journal of controlled release : official journal of the Controlled Release Society 20010706
New HPMA copolymers containing doxorubicin bound via pH-sensitive linkage: synthesis and preliminary in vitro and in vivo biological properties. Journal of controlled release : official journal of the Controlled Release Society 20010518
Preliminary evaluation of caspases-dependent apoptosis signaling pathways of free and HPMA copolymer-bound doxorubicin in human ovarian carcinoma cells. Journal of controlled release : official journal of the Controlled Release Society 20010428
Phase I clinical and pharmacokinetic study of PNU166945, a novel water-soluble polymer-conjugated prodrug of paclitaxel. Anti-cancer drugs 20010401
The influence of a colonic microbiota on HPMA copolymer lectin conjugates binding in rodent intestine. Journal of drug targeting 20010401
Polymer-coated adenovirus permits efficient retargeting and evades neutralising antibodies. Gene therapy 20010301
[Study of 'living' radical polymerization by FTIR in situ]. Guang pu xue yu guang pu fen xi = Guang pu 20010201
The effect of two hydrophilic monomers on the water uptake of a heterocyclic methacrylate system. Biomaterials 20010101
Crosslinkable coatings from phosphorylcholine-based polymers. Biomaterials 20010101
Modification of cyclosporin A and conjugation of its derivative to HPMA copolymers. Bioconjugate chemistry 20010101
Synthetic macromolecular drug carriers: biodistribution of poly[(N-2-hydroxypropyl)methacrylamide] copolymers and their accumulation in solid rat tumors. PDA journal of pharmaceutical science and technology 20010101
N-(2-hydroxypropyl)methacrylamide copolymer-6-(3-aminopropyl)-ellipticine conjugates. Synthesis, in vitro, and preliminary in vivo evaluation. Bioconjugate chemistry 20010101
Enhanced biorecognition and internalization of HPMA copolymers containing multiple or multivalent carbohydrate side-chains by human hepatocarcinoma cells. Bioconjugate chemistry 20010101

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