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274-79-3 | Imidazo[1,2-a]pyrazine
CAS No: 274-79-3 Catalog No: AG003QZE MDL No:MFCD06245371
Product Description
Catalog Number:
AG003QZE
Chemical Name:
Imidazo[1,2-a]pyrazine
CAS Number:
274-79-3
Molecular Formula:
C6H5N3
Molecular Weight:
119.1240
MDL Number:
MFCD06245371
IUPAC Name:
imidazo[1,2-a]pyrazine
InChI:
InChI=1S/C6H5N3/c1-3-9-4-2-8-6(9)5-7-1/h1-5H
InChI Key:
MBVAHHOKMIRXLP-UHFFFAOYSA-N
SMILES:
n1ccn2c(c1)ncc2
Properties
Complexity:
105
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
119.048g/mol
Formal Charge:
0
Heavy Atom Count:
9
Hydrogen Bond Acceptor Count:
2
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
119.127g/mol
Monoisotopic Mass:
119.048g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
30.2A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
0.7
Literature
| Title | Journal |
|---|---|
| Synthesis and SAR studies of imidazo-[1,2-a]-pyrazine Aurora kinase inhibitors with improved off-target kinase selectivity. | Bioorganic & medicinal chemistry letters 20120515 |
| Imidazo[1,2-a]pyrazines as novel PI3K inhibitors. | Bioorganic & medicinal chemistry letters 20120301 |
| Aurora kinase inhibitors based on the imidazo[1,2-a]pyrazine core: fluorine and deuterium incorporation improve oral absorption and exposure. | Journal of medicinal chemistry 20110113 |
| Bioisosteric approach to the discovery of imidazo[1,2-a]pyrazines as potent Aurora kinase inhibitors. | Bioorganic & medicinal chemistry letters 20110101 |
| Combined 3D-QSAR modeling and molecular docking studies on pyrrole-indolin-2-ones as Aurora A kinase inhibitors. | International journal of molecular sciences 20110101 |
| Discovery of orally bioavailable imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors. | Bioorganic & medicinal chemistry letters 20101115 |
| Structure activity relationship studies of imidazo[1,2-a]pyrazine derivatives against cancer cell lines. | European journal of medicinal chemistry 20101101 |
| Structure-based design of imidazo[1,2-a]pyrazine derivatives as selective inhibitors of Aurora-A kinase in cells. | Bioorganic & medicinal chemistry letters 20101015 |
| Discovery of imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors. | Bioorganic & medicinal chemistry letters 20100901 |
| 2-Oxo-2,3-dihydro-1H-imidazo[1,2-a]pyridinium iodide. | Acta crystallographica. Section E, Structure reports online 20100301 |
| Novel imidazo[1,2-a]pyrazine derivatives as potent reversible inhibitors of the gastric H+/K+-ATPase. | Bioorganic & medicinal chemistry 20080101 |
| Imidazo[1,2-a]quinoxalines: synthesis and cyclic nucleotide phosphodiesterase inhibitory activity. | European journal of medicinal chemistry 20010301 |
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