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274-56-6

274-56-6 | Pyrazolo[1,5-a]pyridine

CAS No: 274-56-6 Catalog No: AG003841 MDL No:MFCD08752622

Product Description

Catalog Number:
AG003841
Chemical Name:
Pyrazolo[1,5-a]pyridine
CAS Number:
274-56-6
Molecular Formula:
C7H6N2
Molecular Weight:
118.1359
MDL Number:
MFCD08752622
IUPAC Name:
pyrazolo[1,5-a]pyridine
InChI:
InChI=1S/C7H6N2/c1-2-6-9-7(3-1)4-5-8-9/h1-6H
InChI Key:
DVUBDHRTVYLIPA-UHFFFAOYSA-N
SMILES:
c1ccc2n(c1)ncc2

Properties

Complexity:
103  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
118.053g/mol
Formal Charge:
0
Heavy Atom Count:
9  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
118.139g/mol
Monoisotopic Mass:
118.053g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
17.3A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.1  

Literature

Title Journal
Phosphodiesterase inhibitors. Part 4: design, synthesis and structure-activity relationships of dual PDE3/4-inhibitory fused bicyclic heteroaromatic-4,4-dimethylpyrazolones. Bioorganic & medicinal chemistry letters 20120915
Au(I)-catalyzed and iodine-mediated cyclization of enynylpyrazoles to provide pyrazolo[1,5-a]pyridines. Organic & biomolecular chemistry 20120907
Synthesis and structure-activity relationships of pyrazolo[1,5-a]pyridine derivatives: potent and orally active antagonists of corticotropin-releasing factor 1 receptor. Journal of medicinal chemistry 20120614
Phosphodiesterase inhibitors. Part 3: Design, synthesis and structure-activity relationships of dual PDE3/4-inhibitory fused bicyclic heteroaromatic-dihydropyridazinones with anti-inflammatory and bronchodilatory activity. Bioorganic & medicinal chemistry 20120301
Ultrasound assisted one-pot, three-components synthesis of pyrimido[1,2-a]benzimidazoles and pyrazolo[3,4-b]pyridines: A new access via phenylsulfone synthon. Ultrasonics sonochemistry 20120101
Discovery of pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors. Bioorganic & medicinal chemistry 20120101
Novel pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors: Exploring the benzenesulfonohydrazide SAR. Bioorganic & medicinal chemistry 20120101
Synthesis, X-ray crystal structure and fluorescent spectra of novel pyrazolo[1,5-a]pyrazin-4(5H)-one derivatives. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20111015
Phosphodiesterase inhibitors. Part 2: design, synthesis, and structure-activity relationships of dual PDE3/4-inhibitory pyrazolo[1,5-a]pyridines with anti-inflammatory and bronchodilatory activity. Bioorganic & medicinal chemistry letters 20110915
A copper-mediated cyclization reaction of hydrazine with enediynones providing pyrazolo[1,5-a]pyridines. Organic & biomolecular chemistry 20110207
One-step synthesis of diarylpyrazolo[3,4-b]pyridines from isoflavones. Journal of combinatorial chemistry 20100712
Ethyl 3-{5-[(diethyl-amino)meth-yl]isoxazol-3-yl}-2-phenyl-pyrazolo[1,5-a]pyridine-5-carboxyl-ate. Acta crystallographica. Section E, Structure reports online 20100401
Assessment of the putative binding conformation of a pyrazolopyridine class of inhibitors of MAPKAPK2 using computational studies. European journal of medicinal chemistry 20100101
The first examples of chemical modification of oligomycin A. The Journal of antibiotics 20100101
Novel pyrazolopyrimidines as highly potent B-Raf inhibitors. Bioorganic & medicinal chemistry letters 20091215
An efficient one-step synthesis of heterobiaryl pyrazolo[3,4-b]pyridines via indole ring opening. Organic letters 20091119
Structure-activity relationship study of EphB3 receptor tyrosine kinase inhibitors. Bioorganic & medicinal chemistry letters 20091101
Exploiting the pyrazolo[3,4-d]pyrimidin-4-one ring system as a useful template to obtain potent adenosine deaminase inhibitors. Journal of medicinal chemistry 20090326
The identification of pyrazolo[1,5-a]pyridines as potent p38 kinase inhibitors. Bioorganic & medicinal chemistry letters 20081015
Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors. Bioorganic & medicinal chemistry letters 20080801
Substituted pyrazolo[3,4-b]pyridines as potent A1 adenosine antagonists: synthesis, biological evaluation, and development of an A1 bovine receptor model. ChemMedChem 20080601
Design, synthesis, and biological evaluation of AT1 angiotensin II receptor antagonists based on the pyrazolo[3,4-b]pyridine and related heteroaromatic bicyclic systems. Journal of medicinal chemistry 20080410
Synthesis, radiofluorination, and in vitro evaluation of pyrazolo[1,5-a]pyridine-based dopamine D4 receptor ligands: discovery of an inverse agonist radioligand for PET. Journal of medicinal chemistry 20080327
Concise routes to pyrazolo[1,5-a]pyridin-3-yl pyridazin-3-ones. Organic & biomolecular chemistry 20080107
Pyrazolo[1,5-a]pyrimidines as orally available inhibitors of cyclin-dependent kinase 2. Bioorganic & medicinal chemistry letters 20071115
Rapid hit to lead evaluation of pyrazolo[3,4-d]pyrimidin-4-one as selective and orally bioavailable mGluR1 antagonists. Bioorganic & medicinal chemistry letters 20070801
Synthesis and evaluation of pyrazolo[3,4-b]pyridine CDK1 inhibitors as anti-tumor agents. Bioorganic & medicinal chemistry letters 20070801
Pyrazolo[1,5-a]pyridine antiherpetics: effects of the C3 substituent on antiviral activity. Bioorganic & medicinal chemistry letters 20070515
Synthesis of C-6 substituted pyrazolo[1,5-a]pyridines with potent activity against herpesviruses. Bioorganic & medicinal chemistry 20060215
Pyrazoloheteroaryls: novel p38alpha MAP kinase inhibiting scaffolds with oral activity. Bioorganic & medicinal chemistry letters 20060115
Tissue distribution of radioiodinated FAUC113: assessment of a pyrazolo(1,5-a) pyridine based dopamine D4 receptor radioligand candidate. Nuklearmedizin. Nuclear medicine 20060101
Synthesis of novel substituted 2-phenylpyrazolopyridines with potent activity against herpesviruses. Bioorganic & medicinal chemistry 20050915
New pyrazolo[3,4-b]pyridones as selective A(1) adenosine receptor antagonists: synthesis, biological evaluation and molecular modelling studies. Organic & biomolecular chemistry 20050621
Pyrazolopyridine antiherpetics: SAR of C2' and C7 amine substituents. Bioorganic & medicinal chemistry 20050401
Synthesis and biological evaluation of some acyclic 4,6-disubstituted 1H-pyrazolo[3,4-d]pyrimidine nucleosides. Nucleosides, nucleotides & nucleic acids 20030101
Di- and trisubstituted pyrazolo[1,5-a]pyridine derivatives: synthesis, dopamine receptor binding and ligand efficacy. Bioorganic & medicinal chemistry letters 20020225

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