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274-49-7 | Imidazo[1,5-a]pyrazine
CAS No: 274-49-7 Catalog No: AG007KUZ MDL No:MFCD09263928
Product Description
Catalog Number:
AG007KUZ
Chemical Name:
Imidazo[1,5-a]pyrazine
CAS Number:
274-49-7
Molecular Formula:
C6H5N3
Molecular Weight:
119.1240
MDL Number:
MFCD09263928
IUPAC Name:
imidazo[1,5-a]pyrazine
InChI:
InChI=1S/C6H5N3/c1-2-9-5-8-4-6(9)3-7-1/h1-5H
InChI Key:
MIFJMFOVENWQDP-UHFFFAOYSA-N
SMILES:
n1ccn2c(c1)cnc2
NSC Number:
157973
Properties
Complexity:
105
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
119.048g/mol
Formal Charge:
0
Heavy Atom Count:
9
Hydrogen Bond Acceptor Count:
2
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
119.127g/mol
Monoisotopic Mass:
119.048g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
30.2A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
0.8
Literature
| Title | Journal |
|---|---|
| Structure based design of novel 6,5 heterobicyclic mitogen-activated protein kinase kinase (MEK) inhibitors leading to the discovery of imidazo[1,5-a] pyrazine G-479. | Bioorganic & medicinal chemistry letters 20141001 |
| Synthesis and anticancer activity of oxindole derived imidazo[1,5-a]pyrazines. | European journal of medicinal chemistry 20110601 |
| Imidazo[1,5-a]pyrazines: orally efficacious inhibitors of mTORC1 and mTORC2. | Bioorganic & medicinal chemistry letters 20110401 |
| Synthesis of substituted imidazo[1,5-a]pyrazines via mono-, di-, and directed remote metalation strategies. | Organic letters 20091119 |
| Kinase inhibitors for the treatment of inflammatory and autoimmune disorders. | Purinergic signalling 20090301 |
| A novel synthesis of highly substituted imidazo[1,5-a]pyrazine derivatives by 3-CR/2-CR sequence. | Molecular diversity 20090201 |
| Palladium-catalyzed direct heck arylation of dual pi-deficient/pi-excessive heteroaromatics. Synthesis of C-5 arylated imidazo[1,5-a]pyrazines. | Organic letters 20080717 |
| Novel 2-phenylquinolin-7-yl-derived imidazo[1,5-a]pyrazines as potent insulin-like growth factor-I receptor (IGF-IR) inhibitors. | Bioorganic & medicinal chemistry 20080201 |
| Synthesis and c-Src inhibitory activity of imidazo[1,5-a]pyrazine derivatives as an agent for treatment of acute ischemic stroke. | Bioorganic & medicinal chemistry 20070115 |
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