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Home > Imidazoles > 26259-86-9
26259-86-9 | 1H-Imidazole, 2-(1,3-dioxolan-2-yl)-
CAS No: 26259-86-9 Catalog No: AG002SHD MDL No:
Product Description
Catalog Number:
AG002SHD
Chemical Name:
1H-Imidazole, 2-(1,3-dioxolan-2-yl)-
CAS Number:
26259-86-9
Molecular Formula:
C6H8N2O2
Molecular Weight:
140.1399
IUPAC Name:
2-(1,3-dioxolan-2-yl)-1H-imidazole
InChI:
InChI=1S/C6H8N2O2/c1-2-8-5(7-1)6-9-3-4-10-6/h1-2,6H,3-4H2,(H,7,8)
InChI Key:
YKLHTFLODWHCFD-UHFFFAOYSA-N
SMILES:
C1COC(O1)c1ncc[nH]1
Properties
Complexity:
114
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
140.059g/mol
Formal Charge:
0
Heavy Atom Count:
10
Hydrogen Bond Acceptor Count:
3
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
140.142g/mol
Monoisotopic Mass:
140.059g/mol
Rotatable Bond Count:
1
Topological Polar Surface Area:
47.1A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-0.5
Literature
| Title | Journal |
|---|---|
| Renal Inhibition of Heme Oxygenase-1 Increases Blood Pressure in Angiotensin II-Dependent Hypertension. | International journal of hypertension 20120101 |
| A novel, 'double-clamp' binding mode for human heme oxygenase-1 inhibition. | PloS one 20120101 |
| Novel insights into the vasoprotective role of heme oxygenase-1. | International journal of hypertension 20120101 |
| In vivo inhibition of renal heme oxygenase with an imidazole-dioxolane inhibitor. | Pharmacological research 20100601 |
| Recombinant truncated and microsomal heme oxygenase-1 and -2: differential sensitivity to inhibitors. | Canadian journal of physiology and pharmacology 20100401 |
| Synthesis and evaluation of imidazole-dioxolane compounds as selective heme oxygenase inhibitors: effect of substituents at the 4-position of the dioxolane ring. | Bioorganic & medicinal chemistry 20090315 |
| Inhibition of heme oxygenase activity in newborn mice by azalanstat. | Canadian journal of physiology and pharmacology 20081001 |
| Effectiveness of novel imidazole-dioxolane heme oxygenase inhibitors in renal proximal tubule epithelial cells. | The Journal of pharmacology and experimental therapeutics 20071201 |
| X-ray crystallographic and biochemical characterization of the inhibitory action of an imidazole-dioxolane compound on heme oxygenase. | Biochemistry 20070220 |
| Imidazole-dioxolane compounds as isozyme-selective heme oxygenase inhibitors. | Journal of medicinal chemistry 20060713 |
| Anti-Plasmodium activity of imidazole-dioxolane compounds. | Bioorganic & medicinal chemistry letters 20060501 |
| Selectivity of imidazole-dioxolane compounds for in vitro inhibition of microsomal haem oxygenase isoforms. | British journal of pharmacology 20060201 |
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